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<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTU7</accession>
    <name>U4KTU7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTU7"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="10106" checksum="11D02C4E5C6642F1" modified="2013-12-11" version="1">MGVVVSILLFPIIIVAKAIDLLISTALGLIGFGAVGPIAGSLAAAWQASIGASVAAGSMFAILQSRAMKGVSVLRPVLLAVGLMGAFVLFRALRCSIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUD6</accession>
    <name>U4KUD6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized transporter C1002.16c acc. no. Q9US44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935198">
        <property type="protein sequence ID" value="CCX04326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUD6"/>
    <dbReference type="STRING" id="1076935.U4KUD6"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIWAHAL"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="473" mass="52458" checksum="F7A3102C4AB5ED1D" modified="2013-12-11" version="1">MKSETQKAEDVHSSSDREAGVDIEYEQKLIHKVDWRLLPILGALYSVALIDRTNMSNAAVAGMDVELHLKGTNRYSIALLIFFIPYFIFELPSNLLLRRIGAAKLLGTLAVCWGAVMIGMGFLKDWRLLVVCRAILGFFEAGFFPGAVYIVSSWYVRYEVQKRMAGFYLVSVLVGGFSAILAYGLMQMKGIGGLSGWRWIFIIEGIITVLLGFVAYFTIIDFPDKVLETRNGNFLTASDVELLKARIDRDRDDSTADEITWAKVGKHLGDWKLWVFAMMFMCSTTPSYAFGYFLPQILRGMGFSAAMSQLLSAPPYIFACITAFGMAVLADKTHKRGPVIVFQNLLVIVGLLITAYTKGTGPRYFGIFLGLTGAQGNVPAVLSYQSNNIRMNSKRSVGSALQVGFGAIGGIFASTVFREHDAPKYLNGMWATIGTQLFTMAAVATMTLYFRSQNKKQKEGKVLEGHPNFQYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUU5</accession>
    <name>U4KUU5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUU5"/>
    <dbReference type="OrthoDB" id="5427833at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012791152" evidence="1">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="223" mass="22873" checksum="DE24B7AA8B9BD24A" modified="2013-12-11" version="1">MRFTVFSVLFTLAAAEFNLSTIQSLDKTEVSGGCYMAYTAPIPYCGSDKNSCSSSCIKALNSAAAMIRMKCADSFTGMDSLLRRTIDGGLQGIVCPDSIEISRSSTLVANYMPLSTTVYVEPTGVQAYGAAMTASSVAHGEEAIAIDTRIPEIPKTTTSALALDLGPTPTARVQSFSASPSLAPLPAVSGAPSSQESQTGSAARVVAGWGITVAAVAAAALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUW9</accession>
    <name>U4KUW9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935239">
        <property type="protein sequence ID" value="CCX05233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUW9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="185" mass="21128" checksum="8BDE3C043C98CB2B" modified="2013-12-11" version="1">MQTVHDWEKMNPGVRDKAALNGLVQQIRICDSLLRKFKADSEKHTRRITTSQNRPIWNRCAKIRWHLFHSGDVVKLDGELRIHLGAINLFSNDMHKSLKLLMNAQCTTLSQLRADSGKTTALTTEFLRRIEAYLVTIQAHVAIPKAIGYTWEGDCLSCEAPIKLINAFGRVHIMPLCLLRSFQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVT6</accession>
    <name>U4KVT6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Mediator of RNA polymerase II transcription subunit 22 acc. no. Q6C265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVT6"/>
    <dbReference type="STRING" id="1076935.U4KVT6"/>
    <dbReference type="eggNOG" id="ENOG502SD63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="136" mass="14446" checksum="D505F92481015546" modified="2013-12-11" version="1">MSSDPNAGYRALQARVNTNMTTLLTRFEAIAQLAPVGNKDRTISASETFQIETHASSMIRAAEDLVALTRSMKEAWIFGQLGGGFEGGNPKADEDATIVGEIIREKARVIEKGGVEEVGEAMEGVQTETGAEGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVW7</accession>
    <name>U4KVW7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pentatricopeptide repeat-containing protein At3g53700, chloroplastic acc. no. Q9LFF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVW7"/>
    <dbReference type="STRING" id="1076935.U4KVW7"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QLHTGFW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052308">
        <property type="entry name" value="PPR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47937:SF8">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47937">
        <property type="entry name" value="PLASTID TRANSCRIPTIONALLY ACTIVE CHROMOSOME 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="877" mass="101438" checksum="BBD96CDA3A4B2D16" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW90</accession>
    <name>U4KW90_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW90"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8061" checksum="82812A2C064147A0" modified="2013-12-11" version="1">MSECRRSRGSPSPVHRAYDYVRNAFTSSRSPNYVDAGVDPFRYVDAGVGTSHSSRSSHPSSHRSHNSSSSGYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWF7</accession>
    <name>U4KWF7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWF7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="2037" checksum="3D3B6ACEEF717D0D" modified="2013-12-11" version="1">MILDYRVLLELGYLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWT1</accession>
    <name>U4KWT1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PCON_05989</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CBS 100304</strain>
            <tissue evidence="26">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX06402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4KWT1"/>
    <dbReference type="STRING" id="1076935.U4KWT1"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1003"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CCX06402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1131" mass="121498" checksum="DD575A14B67ADDDB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY29</accession>
    <name>U4KY29_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11025" checksum="822A9F6B1EA371E7" modified="2013-12-11" version="1">MRFDDDGDVDMEQEEALQEKRTKLDIPVAADAEDEVMADAETTKEISAPVEKDCGLQHACCIWNTGVSSKNAGAGININVIGTQVYQRHSWAEVFTPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYK2</accession>
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        <submittedName>
            <fullName evidence="10">Similar to Uncharacterized protein C27B12.07 acc. no. O42997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCX07332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502S831">
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="353" mass="40198" checksum="E60962C64B12865C" modified="2013-12-11" version="1">MSLPRLPFLYPALRRAHTTLRYRHGTAVEPPVQLHPTPPSPPQSKINEIESISKLVNTDNIEARENLSEPLTENVEANTNNESPKQARPPTTAPTKPPTKPPTKPPTTERVNGNFVNGLGERVHHFDTFGSVQRLERSGGFTRGQSVALMKGIRSLLYKNMDDARNSLVSKSDVENETYLFQAACSELRNEMQNTKKIQIDQLRSDRTRIQTDFDLLNQAFLAEIMTLKDELNMMFNDRKMVTRAEQRAMENKIQELNYKITISLQSELKSEIEKLRWITTRRGLIAIATLALFVVTAIRINNSSAEKRHKEKREKERKKREKEEDAMSMATVHNDHQHGTVVHTEAGLVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZI6</accession>
    <name>U4KZI6_PYROM</name>
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        <submittedName>
            <fullName evidence="5">Similar to ADP-ribosylation factor 1-like 1 acc. no. Q94231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935333">
        <property type="protein sequence ID" value="CCX07130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEMIMKE"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="252" mass="27799" checksum="FD540187AE99EAB1" modified="2013-12-11" version="1">MPIACYCLHIRSHLLAPSLVQPPIAPRCLILGPSGSSKTTFLYRLKNNQYFPTVPTNGVNIEELEVTRKTSLVFSDIGGSDRREVRLHFLNSVPIQDLSILYFVDASAPIDTLPGVLEELVYHVTYARHRAGGTKYVGIVLNKQDLIGPRDRAYMVQELKTEVDKVMEMIMKEPLLEKKDDTMMWEVLDGGKLGISAKTGEGVKEVFNTVAKAVFGVEEKHQPKLLETVKHGHMGGHGRLLGAVTGHSAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L006</accession>
    <name>U4L006_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L006"/>
    <dbReference type="STRING" id="1076935.U4L006"/>
    <dbReference type="eggNOG" id="KOG2795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="175"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="553" mass="61925" checksum="A216FDF86695BFCE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0C1</accession>
    <name>U4L0C1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935414">
        <property type="protein sequence ID" value="CCX08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0C1"/>
    <dbReference type="STRING" id="1076935.U4L0C1"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="692"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="5"/>
            <end position="6"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="936" mass="105002" checksum="7EDF20A7C4DFE1CD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0T2</accession>
    <name>U4L0T2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RNA polymerase II-associated protein 1 homolog acc. no. Q9US06</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0T2"/>
    <dbReference type="STRING" id="1076935.U4L0T2"/>
    <dbReference type="eggNOG" id="KOG2478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GAYYYPI"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="462" mass="52336" checksum="540D08B2E5EB9200" modified="2013-12-11" version="1">MSSSSSQRPSAPRTYPQDYIARIRYNNSLPAPIGPPKLLDIPNAAFVQYTDTAFASQLARSEPINIEVDSELGMPLDLVHIPRVFEGDDSVLRPLEPPPPVDPRDRLLLRNAASLGKPTTRTPTGGSNVSFLRRTEYISAEQSRSSFKSTTSTQLVAIPNKNRRSQARPEDSDPVRILAAVLRGFDVANPSEDASSAPSFAIGDKVSQNAERNWKELKHPNKPGVKAVETFPFLPHLEGSSDTGGYMVFKFQTTPADDEKDGHRDIRMDTSLFQPVELSTDADEQEDRKEGFDFYIPDSENTANAVKRKFAYEADGDDDEEFRYNYVRRYETKNTRGIISVDQQPDEIALRLHKGDEYLPRGAYYYPIMARYILRPKRKVKYGVAMTQRTEDEDEDEPAEALKLRIRELNEPEKRRRVEYVSRYEGVEPPAADIDDEQSHANKHEDHDSDHDDEEDAPGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Y8</accession>
    <name>U4L0Y8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Cell cycle control protein cwf20 acc. no. Q9USK4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935416">
        <property type="protein sequence ID" value="CCX08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Y8"/>
    <dbReference type="STRING" id="1076935.U4L0Y8"/>
    <dbReference type="eggNOG" id="ENOG502RR3S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KPLMFRP"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="353" mass="38125" checksum="766B155EBB31C7E6" modified="2013-12-11" version="1">MLDLDYGSDSDSSETETFVTPRAPSPPPKPTSGLFSLLPKPKKGKDKDANANPDAPKKIVVNLPKFDDVEEDRPAKKARTGGGISGLSAMLPAPKRKAPVGAPPPPPSIEEPVHEPVMKEDKELPKIEATSKANTAFIPQSLARKPIQPMSAFKKKKGTTGAGASAASAGATKKVESPKPQVSLFGSVSTVASAPKRKKTVPTGEYKPIMLEAAQPMKKPADDTEYLEEDPNFGQTSQAYSGQSMAEEPQDLHQLVEHAGLDENAMRQLYGRHGRGSESIKFTTFSVDDEYRQNERDRESGLAQEVKPVRTVAPGRHQLQSLLNIAQSQKGALEDSFARGKSNRKESASKYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L147</accession>
    <name>U4L147_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L147"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="33" mass="3583" checksum="8AB7533E0B7A1606" modified="2013-12-11" version="1">MKRLSGPGKYPEHARGSSHGQATPHTPSLTRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1H9</accession>
    <name>U4L1H9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Sterol uptake control protein 2 acc. no. Q12151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_05541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935277">
        <property type="protein sequence ID" value="CCX05954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1H9"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="333" mass="37931" checksum="283CD450B6A770E1" modified="2013-12-11" version="1">MPKTSKNKQTGEQIGEQIGKPELKKRSKLGCRQCCTRKVKCDEVRPACGQCSKYKKGAQASECDWTPRLQGSKTRPVTISRRRDNPSNLCPRSNSTPPGGSRLKGNLSQSLRSTSVPIGSSHFQSLASKSTTSLPSHHSSGPLLNGIPFPSLYNLQAIRRRQTSPELQTLHENELLYHATKTLNSNLETAYNDLFQQITAEEEQTRALYWSVLEDCWKLEFQSPLSRELMWNWPWDLEVKRMRQALDIAYSHLKETLQKEAVLQEEIQEQVVREQVVREQVVQEQVSQEEELIGFKLDNAAWQELLEQSALGMDGVLSSFEGYDEFSWDSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1I4</accession>
    <name>U4L1I4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1I4"/>
    <dbReference type="OrthoDB" id="10595385at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22314" checksum="1ED0D3D62591F323" modified="2013-12-11" version="1">MENTEQASVSDSSGITTSTTTTEAPQPTQSDAIDIDDHSNHSHNSESDEDDESDEGEKSDEGDESDEGDESDSNESSSNDDSDEDESSAHDDSDGSSSSDDNTSNLRGAGDFETAEEFHRYLLHIRSIVQIPLDAPQRYGHWHSNPRVSMMEVLIQVRRTRMLCDFAASEDDDSEEGSEEDGRWMPCYTHRRLDREGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1P4</accession>
    <name>U4L1P4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935501">
        <property type="protein sequence ID" value="CCX09975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1P4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="296" mass="33858" checksum="792262E6C70A6354" modified="2013-12-11" version="1">MKGPAMMPEGQQGSWALLDEHIVQQTRGPPVVFEASVELLFCYTRFDHNIDSLQVFMLLVAFKRGLLSAVDYIFDNAQQLGASSEPVHDLTGLMEECLKLVATPTEEVDRSIEPAAHESGCTDNSMEYSWFFRQHFHGPLLLWIIRHNRVRFAELLLEGTELEGRPPAKTTLERWLCPYCAAYEGRHTAIELLIQNGMDPNTMGETPEQEKLHMRLHIGEYNIYEPSHNSLIWLAMIESTESSTIALFRGGYRLANLPDPLSVIKLALTRQRLDTLECILRQRQEITREHPVELWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1U5</accession>
    <name>U4L1U5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1U5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="84" mass="10079" checksum="B4809DB31D3997B3" modified="2013-12-11" version="1">MRFACHIWIQLLKEQFRADMRCGRNIGRSRTRPKVDRYRTSILQKSLVALRPHTLVKRVVVLCTTNRCRKCTYPLHSVWYIGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2C3</accession>
    <name>U4L2C3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935501">
        <property type="protein sequence ID" value="CCX09984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="12" mass="1449" checksum="37D9DFFB9A333B18" modified="2013-12-11" version="1">MARRGEKKTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2W8</accession>
    <name>U4L2W8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">PCON_06185</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">CBS 100304</strain>
            <tissue evidence="30">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2W8"/>
    <dbReference type="STRING" id="1076935.U4L2W8"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CCX06598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="237" mass="26649" checksum="A1102B8E250D65D0" modified="2013-12-11" version="1">MAATEAPRELIKQGAEALVYKTTYLLPTIPALLKHRPRKPYRHPTLDLRLTKHRCLSETRLLTRCRGLGIPVPAVYFVDEARGEIYMEWISGRSIREVLDAMIAEGRKEEVNDLMKKMGQVVAKLHQNDIVHGDLTTSNVMVRGERKSGLLAGATMEKVDAEVVLIDLGLGMMSTQEEDKAVDLYVLERAFLSTHPQAEDLFQDVLTAYEGSFKGAKAVMKRLADVRMRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2X4</accession>
    <name>U4L2X4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAF"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
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    </dbReference>
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        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="364"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="807" mass="89523" checksum="56693FC9C27D2556" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <end position="52"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="52" mass="6045" checksum="AABD1CBB497E9D6A" modified="2013-12-11" version="1">MFRLWVAGWSWVARRSGERKARRNARRTQSSGHHSGHHSGHYSGHHSGHHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L441</accession>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX04825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="117" mass="13835" checksum="68DFC6EC6ECF26B6" modified="2013-12-11" version="1">MVHSSHFVQHFAVPPRFEFFNDSVCCSDIHRPLLHSVLSPSDLGRALWTRLVMNTNFNAKRQPPDQAKTPRLPPSGGWNHISRRHTLIFMDGYEYLNHTRHVRRAWATLFQYETYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4E0</accession>
    <name>U4L4E0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">PCON_10189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4E0"/>
    <dbReference type="STRING" id="1076935.U4L4E0"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="292" mass="32528" checksum="F0E906CCE57B6377" modified="2013-12-11" version="1">MSLHTLRPAVRQLRTLRAVRAHSTHGSSASFDPLEVSHFNALASEWWDPHGSSRLLHLMNPLRLQFLSSCLSKHGDATKNMKYLDVGCGGGILAESLARLKGTESVIGVDPTPEVLKIARGHMRQDPALQRRLRYVGATIDTLEKVLAEEGGRELKEGWEGERTMFDVVTTMEVVEHVPHPTRFLKECMQHVRPGGWVVGSTIARTWTSYLTTKLVAEDILGIVPKGTHDWNKYVNANELDSFFRGQDGWGGKHGEDIVFLGCAYIPGLGWKMVPGGEKVGNYFFGIRRNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4J9</accession>
    <name>U4L4J9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Mannose-6-phosphate isomerase acc. no. Q870Y1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4J9"/>
    <dbReference type="STRING" id="1076935.U4L4J9"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECMARND"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="3">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="420" mass="46813" checksum="899DC7DA63E25995" modified="2013-12-11" version="1">MTSPFLRLRCDLQIAPYGKKGSSSLAAHYATATPENEYTIDENVHYGEIWFGDHPKHPSRTLDGTLLANLVEADVDGFLTNAVYERFKDLHGKHIPFLFKILSFDKALPLQAHPHRKPEVAVTLSDTFDGFLGFRPVSEVKSFLKHVPELRKVLSDHETVEAFLAAPEGENGEGTEETKRLLKTLFTELLKTASTEMRAAMDQLLTHVERGTADEALGELGRQEGFRDAVEKCLRDWPKDTGVFAALFFCNFVRRSKAQGIVVPKDCIHAYLEGDVVECMARNDYMIACGLSGPEEKVSPEKFARELDFSPKPSTSFDMKHDTWERSENGKTRIYYSPWDEFDLLYTKLASGEKDKTGGGVAGPTILVVTEGEVLMKHHGGLQKENLKKGQVVFVKPGNGWEWEAAEGGAEVWGAFVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4K6</accession>
    <name>U4L4K6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935666">
        <property type="protein sequence ID" value="CCX11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4K6"/>
    <dbReference type="OrthoDB" id="5435231at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="554" mass="62127" checksum="7E4EA5D24E89BC05" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4M1</accession>
    <name>U4L4M1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to type I phosphodiesterase/nucleotide pyrophosphatase [Metarhizium acridum CQMa 102] acc. no. EFY87699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935619">
        <property type="protein sequence ID" value="CCX11449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4M1"/>
    <dbReference type="STRING" id="1076935.U4L4M1"/>
    <dbReference type="eggNOG" id="ENOG502RXP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CVPVYPH"/>
    <dbReference type="OrthoDB" id="2118639at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651283" evidence="1">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="493" mass="53158" checksum="3E1C096F09A0CAD8" modified="2013-12-11" version="1">MHAFRTLALAVLSLGLAAEARPQSSAYKHVAVFSIDGLHASDVEKYLAARPKSTIASLLETGYEYTQAYTSAPSDSFPGAQAQFTGASPRTHGVWYDDTWDRTYFAPGSDCTGKPGAEVVYTEALDYDGTALFSGGINPANLPKALVNGVCTAVWPHQRLRVNTVFEVVNSKGLATAYTDKHPAYDMINAVAVAVNETIGYDQYHVDAFLNWIDGKDPQHSEGSLKGKTPTLFGGNFQSVSVTQKTVGYQNATGNPFTPQLLKALDFVDNSLGQIVNKLKSKGIYEDTLIVVASKHGQAAIDPAKYRKIAPSLVTKAAGIPIAFQTSDDIANLFLENHADVLKAVAGLKTQAKALAIVDIIYGERLIEMGFGNPLVDPAVPDIIVRPEVGIIYTNSNSKIAEHGGISDDDRHVGVFVPNPKLKQRKISTKTETKQIGPTILKALGLNPLELKGAVIEKTELLEGFEVLEGFENFVQGFKGFKGFKGFKGFKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4P1</accession>
    <name>U4L4P1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
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</entry>
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</entry>
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            <dbReference type="PubMed" id="24068976"/>
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        </source>
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            <dbReference type="EMBL" id="CCX12242.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L669</accession>
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            <fullName evidence="3">Similar to Myocardin acc. no. Q8VIM5</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">PCON_12454</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
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        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="613" mass="67205" checksum="794E13ADFB80596D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6I6</accession>
    <name>U4L6I6_PYROM</name>
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        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">PCON_11684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX12090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6I6"/>
    <dbReference type="STRING" id="1076935.U4L6I6"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX12090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="9967" checksum="BA7B8CDC8648C6CE" modified="2013-12-11" version="1">MDSLQSLILDGFIDFEGQKLADFLTTVLLIVFGAIAWIVGFLRQDLMYTVYIGLGGTALTFLAVVPPWPFYNKNPQRWLAAGEGDRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7N9</accession>
    <name>U4L7N9_PYROM</name>
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        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08522</name>
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    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6431331at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="296"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="479"/>
        </location>
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        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="525" mass="59056" checksum="0994466EF5F72C5C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7P0</accession>
    <name>U4L7P0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7P0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="5723" checksum="EB0E979BB22F8D3D" modified="2013-12-11" version="1">MFPVIAPIISNPGASNPLPSISRCSSPMHPTNRKCAPQRARQSRICTAGHNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7P8</accession>
    <name>U4L7P8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_13291</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7P8"/>
    <dbReference type="STRING" id="1076935.U4L7P8"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="363"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="751" mass="86177" checksum="FBEA1D69467E60D6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8F9</accession>
    <name>U4L8F9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935478">
        <property type="protein sequence ID" value="CCX09658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8F9"/>
    <dbReference type="eggNOG" id="ENOG502SD3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKHAISF"/>
    <dbReference type="OrthoDB" id="4159136at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="151" mass="16063" checksum="4DCE5D04EE2651C5" modified="2013-12-11" version="1">MSAPYIRTGRGGAGNHIPAEEARSEDLEAAKEGGVANAMAADQMMEATPGEYKHTGRGGAGNYYEPSNLQQTGTIEPVIEDHEPSTEQPAIRQWTGRGGAGNFAASHGPTPEEIEAKEREQAKKLQEEVRKSVESSLPKPMGAHLGGRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8I3</accession>
    <name>U4L8I3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Putative malic acid transport protein acc. no. O59815</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936105">
        <property type="protein sequence ID" value="CCX14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8I3"/>
    <dbReference type="STRING" id="1076935.U4L8I3"/>
    <dbReference type="eggNOG" id="ENOG502QV03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWWPMVF"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="411" mass="45477" checksum="846E7BEF56B2A394" modified="2013-12-11" version="1">MSAREGRRIEVNGRGIDDRTPLLPHNHDERFRRRRGDLPMWRHVLYHKMTWAWYNTVVATGSISLILYDLPYRVHRLWVLGSIVYIASLILFVFTFAVHLLRFMIKPSLIPRSMKHPDEGNHVSSLAAAMGVLILNGVTYSEKIHGYNPNAMRTFFWIFIVLSTVFGIMQPLIQFGKPIQEHRVRRDFTPAGMTPVIPLLLAGPVAAGVLAHLEPKLHHTALGIFAFGVALQGMGIFLSLLYSANILERLHREGFPPSHERPGLFLASIPPALTSWAFSSLAAQAVRHFPPNGGAPGGNPDFVVGGVALSYVGVAASLLFWGLAVWWFFVAALANLGQILNLGSDVLEGFMVVFAHAAMFLANNQLLRIFEWPKALTVTNEVLGVATVVVWGILVVGCMIGLVTGRLLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8K1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_01229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="12936" checksum="41FAEB488195D26F" modified="2013-12-11" version="1">MATLPVIDIEAQLRPNTEAVEQVQQVQQRMLHSMERMERAQHQTNVAMLKIQQIQPGFHRELQQVKQFVHHTRDVQWEMYQQIGNIRHEMWEIRQDISHLVTDTDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8S9</accession>
    <name>U4L8S9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10667677at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="17672" checksum="90985DEBC1AE01B7" modified="2013-12-11" version="1">MLPMLTSSRPNKTQTGKSVSGGYAHPNQRGKVIVPRNLTAPHTKHAGDGVAIDLSFESLPIHDIWAYAITSLESVVPDLVQDWHQDLLDYGYNLQGSSMFLAYGYVLMGYGATAHVDSGDPHFTAGFWVDRLAHERPGDKQLFFPELYHLCSPYPVKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8T6</accession>
    <name>U4L8T6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10682398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="385" mass="44103" checksum="8FB950FD0BFCD0FC" modified="2013-12-11" version="1">MFWNISNRKWQRRVRAATLDTLKCYTACKRVGLSYQSHRSVDCSHVPGCSLVLLLSQSVQGYSSREAHGWHADLLVCCALFLPHPRIQHQIPPILLHSRLSIINLPVKSAHTRLYLTSRKTPIMAEDSPFNRKTYGLPEDSRPFISDRTIREQRLKAARKTPRVSIGRSTSGTSKRRDSADIERLGSMGIRESQAHASKIANELFDVKMKLHFEQEKSAKLEHKLTTFMALYNQKLEELEAYKMKVHEMHDTIQALHEGLENQDSILEDSRCINQAYQERFEEIQFKIELHLEHDMKSTDLSPRESQSPAIFVEPKHCSSTDSNYKVTSVKLRSVSESEPESKKGSPTYTRNYVPRYTKKRLVRQAQSLIEEQISRRGGSSGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8V4</accession>
    <name>U4L8V4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935820">
        <property type="protein sequence ID" value="CCX13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8V4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="112" mass="11998" checksum="84890FDF4E7C36F5" modified="2013-12-11" version="1">MTTTHIAPAATKVTTSQCPPTTPVNSLLSPDKLALSNCPTLASSRHDPNSMWKFKLDMRYSTPVYPGSSRGTELMKLAIDNACPAIGIGARHCKGNANQSIDPPPNTFIQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9D8</accession>
    <name>U4L9D8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CTP-dependent diacylglycerol kinase 1 acc. no. P87170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="32700" checksum="4581BEDDACFA8E3B" modified="2013-12-11" version="1">MSSTPDSTLSASSSQISLPDHLDSDNSSTPSTSTSASSSPRSWSPAATKNGFLAPPAGVRATLSRSPSPLGLIPVHRTFSKFVHKHEIPRKALHVSIGFLAIYLYRTEVHPNALIAPLTTALVPIVSADILRLRSESFNQLYIKVLGALMRESEVKGWNGVIWYLVGTVAVLVLFPKDVATLSIALLSWCDTAASTFGRLWGRHTMQIRKGKSLAGSLAAAAVGVMAAGFWWGWVIHGITEDGGVMWRGRLGIAGMEITGGLALTVMSLVTGLVASASEMLDLWGLDDNVIIPVVSGAGIWGLLKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9Q4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="1803" checksum="C2CA3CFDC66DC77D" modified="2013-12-11" version="1">MVGQDRVMLRSAGRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA25</accession>
    <name>U4LA25_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein max acc. no. P91664</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCON_10157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="10084" checksum="CE33BB096C66B32E" modified="2013-12-11" version="1">MSASAERPRLTEQEKKNNHIASEQKRREAIRQGFDRLTEIVPGLEGQGRSESIVLKKSVEHMREVLQERQVLIERIQALGGEIPPELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAA7</accession>
    <name>U4LAA7_PYROM</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="8168" checksum="2FEA679AEE076968" modified="2013-12-11" version="1">MVSFLPRRVYDSDPVSMSYRKVCSWFNFHSFASSMAFSTTISRLFSFSSTYLTDLEFYTRIQCTHPALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAM4</accession>
    <name>U4LAM4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAM4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9512" checksum="F4BFF307BCA455A4" modified="2013-12-11" version="1">MIDDQSTVRPGWSKTFNKILQLPDRPFASGVFDVTITATAPCQVLQLCITIIGKLLCATVGFRDNNYNVTTLSQPWTYLGCGASQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAQ8</accession>
    <name>U4LAQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative ankyrin repeat protein L93 acc. no. Q5UPG5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAQ8"/>
    <dbReference type="STRING" id="1076935.U4LAQ8"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INACSNE"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="294" mass="32950" checksum="EEC47192A775D34E" modified="2013-12-11" version="1">MSERDEYRSCVRLLLSREDIGVNVKDKTGTALLWARDRGHVGIVKLLLERDDIDWNSKDKSGVSTLIWACLCGHESIVKLLLEREGVDVNAKAIDGKTALTCAYRRDYESIVKLLLAREEVDVGATAINGETILTLACLRGDERFVKLLLEREEVDLNAKQEDGETALMWACYGGHESNVKLLLERKEVDINAKVMHGETVLIWACRRGREEVTEILLKREDIKVDVKYGDERPALMWACAGGYKEVVKISLARGSVVISAKDSRGKTAMDLANERGNVDIAKMLQEFIDSQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC44</accession>
    <name>U4LC44_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC44"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8887" checksum="54F0243EED3881BF" modified="2013-12-11" version="1">MYTAYHGTASNLVLSSTTISYPSCLTKSIDNPPELTITSHRHCDEYFKRSITGKSSQVTIQYDLKPILHIHPTASHAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC55</accession>
    <name>U4LC55_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC55"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="113" mass="12662" checksum="D6D54CDB73B2BB00" modified="2013-12-11" version="1">MLSMDVFITMHLNYTLSKQVRPFFQMNIFTRQISSSTSLISFQPQKPRSTATTYRTSHQSVGVTRFSLKVFTAFLFTTKTVSNLNTIRHQPALSTNNGTNCQPGGGHTSSPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC62</accession>
    <name>U4LC62_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Psi-producing oxygenase A acc. no. Q6RET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC62"/>
    <dbReference type="STRING" id="1076935.U4LC62"/>
    <dbReference type="OrthoDB" id="5427842at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14515" checksum="CB18FAE7DE30EA20" modified="2013-12-11" version="1">MASRLLSIFFKANGADSTPSHFGDETLASNKNVKAGILADLQGLIGNHSTDAATILEMIEHGISGAPTDDKSLLLERIIQLVACMPRTSPNREILSGKHLNNLWGSLQHPPLTYVGDKTRYRQADGSHNPELTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCT6</accession>
    <name>U4LCT6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCT6"/>
    <dbReference type="OrthoDB" id="10332483at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651247" evidence="3">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="20873" checksum="51FC8A1330C1D1BD" modified="2013-12-11" version="1">MLQFPICLVANLVLTPTKASAVALPWQSVDNYDAATYPTGEGKNWGAGYAPPNPTGLAVGVGLIGGLSIVAIIAFVILWYRHRHELKEMEESYAENQKRPKGSPDLSNGEAGWGSNPTSPVISPITNFKNPVVVESMPASPEPIMNADPRYMENTRRSIIKESLQRKPVPSEIQYTAMPEPAMRQDRSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDM1</accession>
    <name>U4LDM1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="3">CBS 100304</strain>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="84" mass="9519" checksum="34A7C9EEB22A4D25" modified="2013-12-11" version="1">MKFVVVFITSFFITATISLVIPELKDAEDPKVEFSDKVFSATSSRTSPQNCYYTTCGNIWCFKQGYTQRGGMSSCYNIRCCQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
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            <begin position="1"/>
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            <end position="35"/>
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            <end position="76"/>
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            <begin position="108"/>
            <end position="118"/>
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    </feature>
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            <begin position="209"/>
            <end position="226"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX09229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="430" mass="46295" checksum="AC31368973BA139A" modified="2013-12-11" version="1">MDRLKEIGSSAREKAGLAPKKSYHNYSDSRISTAKTHPDTLSKIKGLVPDRVTGIVSRGRSGSNSSQDSAPSSYRSHTVVDPASFGPPPKHRAAYGDEIASASIAGGAPPPYDSPPGAPLQRRATIEAPESRRAPPPPPRIPSRRGTESYPASREVTDEDVASRGGLSTGAVGALGQLGKSGIHIPGFGTSKETAPPPPPTSSRPKIGSTASRWRTNSDAAPTGTTLEEKKAAVKTIDQLYKDPTKVSFKDAKAAAGTARNFQQRHGGQVAEGARLANKYGLIGNEMTREPTQQSDIRTPPSPQSPQHVKYEPPPPPRRSVPSTPTAPDRHQLLQHNTIRHRLHKDLYHPRYQLGNPHHLYPPNEEASPTITSYYRITAPTSSRSYLISTASDTANISSFAVFRILANFVFRLLSAEFRIPATSNSRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
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        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64554" checksum="18D81B781AF48079" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEJ0</accession>
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    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
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            <end position="32"/>
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        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="488" mass="56143" checksum="253DEB5AD9C3945F" modified="2013-12-11" version="1">MLRITPATTRLTRKIRQCFSTSARSPEESTSWKPPVASRSTNTDNTANYTNDAADDKDRVTWRGNTKPVHSKKPAFKSKFPARYPKPGKFHGKEVDSEFPIRVKKREAGKAYDVEAPPASPLLDEHIFLPFNKKFPKAGKKKPTQMSPREWALSVNPYAWILASPPRQDVDHHTRIPNMLLQRFRVVRNPDTGAPHILPGFGYKQKIGSKGMWALSSHAAITSLCPNVGRGGKKWLILVDHQHREMIQKTGVWRQDMPDYILQLMQKKTVDALIDENPNKVGVLSEKVDRIIGGPEYWETIGQVSAVIDFRSDEQVKAIEKMTEEEKEKYYSWENAKLEGVVYKNGVGHKPYRPPKMDKDRSMARVQGKLVPVHKVNMMLNGYQEARLREAWGIGERYDVVALMSTPRTTWPLMWLMRLRGYLGLEYAPERTANVDENDDDDEYDEEDENAEVIHNLDEYGDEDEYGQDLDELTNNKFSEEQDEVDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFK2</accession>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="26682" checksum="D68BDB3126368DB6" modified="2013-12-11" version="1">MASHPPTALSRSHEDPPPSYEDSEDEGLGAPPTYEDSASEKRSRSQRTSPPPSYQEPSSTPSRKTRSTRTNRIRRRARRHKTPNESNPAMHNDAPDSCNPTHRYRPQAQSASTSTTASITGNSQSRDAPQGPWQTPDDDDEWYTPPGAENRIDYIDPATGKLKYPHCWPDFKSSEHPDNFRHMFTLVLVIITVTIPLMLLLYLAWDNFRNTLVNDPDPLKAPYNDEDDYVYDKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGM2</accession>
    <name>U4LGM2_PYROM</name>
    <protein>
        <submittedName>
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    </protein>
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    </gene>
    <organism evidence="6 7">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGM2"/>
    <dbReference type="STRING" id="1076935.U4LGM2"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WFEESSN"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="531" mass="59233" checksum="EAD41AC7AC47BB91" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGS5</accession>
    <name>U4LGS5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGS5"/>
    <dbReference type="STRING" id="1076935.U4LGS5"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651358" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="9752" checksum="47E1DE6A76DCC0B5" modified="2013-12-11" version="1">MQFTTIISVLAFSATVFGAAIEKRSGPVGVCPTYREDAHFLLADSSDCTVFYKCDRNGPVKLSCPEGLLYAPQHQWCDFPERSTCKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGS8</accession>
    <name>U4LGS8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Transcription factor steA acc. no. O74252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935561">
        <property type="protein sequence ID" value="CCX31284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGS8"/>
    <dbReference type="STRING" id="1076935.U4LGS8"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FNAKAMY"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX31284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="791" mass="88809" checksum="284C150188FD8537" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHJ5</accession>
    <name>U4LHJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936278">
        <property type="protein sequence ID" value="CCX15960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHJ5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13391" checksum="C4288FA7D3360F97" modified="2013-12-11" version="1">MGPPDELARKGLSLQRRDPPPLSISTLRRYVRAEFLEQMRTRWENIPAARKGQSYQGAWRQKLLGGLIMKPVTLFDSFPGLLRAVRATPAFNTSRILVHHDLLFAHLHRPALLAAPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHJ9</accession>
    <name>U4LHJ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to tRNA1(Val) (Adenine(37)-N6)-methyltransferase acc. no. C6X2D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936282">
        <property type="protein sequence ID" value="CCX15965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHJ9"/>
    <dbReference type="STRING" id="1076935.U4LHJ9"/>
    <dbReference type="OMA" id="YLSKWCR"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="263" mass="30088" checksum="D18C13A8EC9BA463" modified="2013-12-11" version="1">MPELGIDPNVFEKPDDKDYDSAGYDTSTESLASSIYQYLFENGRRYHSYYGTEEYFLPTNETEQDRYVVGMVEQLNGWSDKFSLDLHHEIMTLAWENNLYKAPLTDPRRILDIGTGTRIWGIDMAEKSPNAEVIGTDLSPVQPNWAPQNCNFEVDDAMSERTYLDISGARVPSVGFEEVTTSKVKKPLGPWAKDPRMQRIGAMVLLHSETIFESYGMAAFTCVLGMDQEKARDICDRAMVASRNKNYYIYSFYYRAYGQKPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI26</accession>
    <name>U4LI26_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936375">
        <property type="protein sequence ID" value="CCX16313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI26"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="8960" checksum="DEF47F1D2D9678C1" modified="2013-12-11" version="1">MVWFAIKECSAVSSLLKNIQASSIEDKTGVRAISRSEVPLSEHEAALSRRIRHTSLVLVRSFCNKVHFTSLAFHSSFVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LII5</accession>
    <name>U4LII5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LII5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="127" mass="14229" checksum="1849DB3B6EDCCF6C" modified="2013-12-11" version="1">MYHRVWFPALQTLLIPSGSCYTRVGTLPRTPSPFHSPSRFYATMSRYSRTLQVPKNSAFSLQKEIPIWYIVDSAAQTQKEDLCGPDALTVVGLSLIMSFCGLLFALQATISIQVSFLHSLRCRVKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIK5</accession>
    <name>U4LIK5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936465">
        <property type="protein sequence ID" value="CCX16602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIK5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2684" checksum="D6CF7369F6FC1BE3" modified="2013-12-11" version="1">MEQIYRSQLASYTCIVKFNEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIM3</accession>
    <name>U4LIM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to U4/U6 small nuclear ribonucleoprotein Prp31 acc. no. Q8CCF0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_12021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIM3"/>
    <dbReference type="STRING" id="1076935.U4LIM3"/>
    <dbReference type="eggNOG" id="KOG2574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IGNGPMD"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="270"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="603" mass="65112" checksum="122E0FB1FA076991" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ54</accession>
    <name>U4LJ54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized protein C22E12.18 acc. no. Q10368</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ54"/>
    <dbReference type="STRING" id="1076935.U4LJ54"/>
    <dbReference type="eggNOG" id="ENOG502QZAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSKTWLK"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651640" evidence="2">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="3">
        <location>
            <begin position="52"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="36145" checksum="E4BF4F0F77C79C00" modified="2013-12-11" version="1">MPSAVPNTPLTPLFATLITLITHLRASINTPTSSTIAAAADSNVSPLDLLFSAATLLRAHVTRLSISLRPPVTVEAAEKDLTTLSATILPSLVAAVTACSADAHGALLVSEVRASVDQLLAAVGEYVAGAETGGDRLLNTGIVWSAADRVIALKATGLAGLVQKQMEMWQKTVKDAAKELKEFIETVDLGDDEDENGDQDEELKDEEQAFWDRPTRKQALDEETKKAAEEGLKKIKMCGVLLGVAREGRLHGETRLTDVKRVDGMARAAKEISGLADDLGMAFYDEEELEDVEEAKQQLVKKAVELCNLCLLNDEEEKDALSRTFENALVVLQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK07</accession>
    <name>U4LK07_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_13073</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK07"/>
    <dbReference type="STRING" id="1076935.U4LK07"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX32424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="472" mass="52163" checksum="8D222EE2805682A3" modified="2013-12-11" version="1">MFCQPFPRVKVLKPFRSLATVLTPPKPILPQRATFEIQNGPSYQGISFGFPKPISGEAVYTTSIVGYPESMTDPSYSGQILVFTQPIIGNIGAPSPMKDDYGLYRFLESGKIHCSGIIVSDYSAKFSHWSAIQSLGDWCIQSGIPAISGVDTRSIVTHLRDSGHAMSRINMDGPSVEQFSGQELVELDGLVNYSETTEKVPFTNPNTRHLAAEASTKAPFHIPSGPIHVALVDFGVKENILRSLVSRGVSVTVFPHDYPIQTIAKHFDGVFLSNGPGNPRMCTAAIDNLRFLLASYEGPIMGICLGHQLLALAIGAETNHLRYGNRGHNIAVEDKQTGQYIITSQNHGFAVDPATIPDDWMELYTNVNDGSNEGMCHRTRPIMSTQFHPEAKGGPRDAMYTFDNYVIECGRFKVKSAIRTAENPLAWVKNLPRERVIDVEEVKRVEKVLEKAIKKQEKKVFQETGLFCPFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKI9</accession>
    <name>U4LKI9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Argonaute-binding protein 1 acc. no. Q9P7B8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKI9"/>
    <dbReference type="STRING" id="1076935.U4LKI9"/>
    <dbReference type="eggNOG" id="ENOG502S0TP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKPTGFE"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="459" mass="51818" checksum="96720FEFC39F1C3E" modified="2013-12-11" version="1">MAPSVVPPQPTVEDSREDAAAGMQNQDAADDAASGDEAEAQQPKGNGVQTPTGGAPPKKKKKKRTRKIGHTKPSGWEEYCVDGPLPLSVVQEELELYSPKKPFIARIELCIQRYKAKRKWDTLRLQMFTNYLTLGGVSSGQKQFSGGLDPKKIDEMDAEDIAAITATEFINVGQAGGDDDEWDVDFELVARGFLSYKVPHVMGISKEKELMTAVNIVRNFLNYVIAHNVAPEYEANIRAALKICDLAEQELVLCLNLTTRLPGTFNTACSTIYQGHYQNLGDEDMSWMPEEERHRSIFFTREEATSLVETALKKRGTPEQQALGVGRKVVKRHFLSVQVIEVYNPPSEWVQDKDADKTLPENKYYQKTQTLGWIKVKPWVPEDPYVIPEELPLDQLDEITIWLEKTVVQWCFVGMKMATKIHWFEDGLVFMDDVTGLYTSFYLPLENPKEDEGDDDEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKK5</accession>
    <name>U4LKK5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKK5"/>
    <dbReference type="eggNOG" id="ENOG502SATA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5426707at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="14507" checksum="3AC4292B01578379" modified="2013-12-11" version="1">MFSRHHRTRPYGSTTTTSTVVTKKPSLLSRLTRPRGARTSTTRRHHGAGYGSTMGSSTAAPVALNRPRRRTSISDKISGALLRLKGSLTGRPGQKAAGTRRMRGTDGRGVHATTTTRRHGGSRVGGGRRYRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKN7</accession>
    <name>U4LKN7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Syntaxin-18 acc. no. Q8VDS8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKN7"/>
    <dbReference type="STRING" id="1076935.U4LKN7"/>
    <dbReference type="eggNOG" id="KOG3894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YRIRTHI"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="234"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="324" mass="36860" checksum="D3D90D626085CF5A" modified="2013-12-11" version="1">MTDLTPLFSDLLQKKDSPGIPNNKKPPPPSDEFLKEAYLIATHISSLLQNLQQTRKSYLSTARAPVSSHRASTAVFLTDAQRDSLDAETKALIRATLSLINRLESAEKIRVKTETNLFKKKHNSFKALFEDEAIRNAEEAGLKMVTAHREGVIWFLKNRLEQASEEQKERQEVRLQRQIERGKSLLHKAPTRPAPQITISQAAMEQEDQKDREAAEQLSPEQLRIFEKENEGMVKYYEDTLEQVKTAESSLLEISELQTQLANNLAVQNVHIDHLVMDSLATTENVQRGNQQLKKASEKVSIARSAFFGTVVFCSVVFVWDWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM14</accession>
    <name>U4LM14_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_14224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM14"/>
    <dbReference type="OrthoDB" id="10543460at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="26336" checksum="87D9D45A694E8BB5" modified="2013-12-11" version="1">MPDTAQDIAPHCPTSQKANIISESKQSPVSRKNSALSLDLAFVAGVASLILKVRNIFRRKKKAVDYTDLSNSTSGPQSPATTTIVPLNPPKLLEKPPSTSAPPNMSQPVPRYSIEQNSDAQKASSLYGTPRPIPAKGPQETVHITGISEYTNSSEKARYYRTTEAFRRQIILAARKQKIPLTIDLYKNSEEKGSGPVVVIYGAGSYGLKNDVKKALESELLTYDVYLYENPDRWRQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM75</accession>
    <name>U4LM75_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Leptomycin B resistance protein pmd1 acc. no. P36619</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_01211</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX14985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM75"/>
    <dbReference type="STRING" id="1076935.U4LM75"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRIAYHE"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000240">
        <property type="entry name" value="ABC transporter B family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="125"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="458"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="828"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="938"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX14985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128496" checksum="4E5F3B445A50E06F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMP6</accession>
    <name>U4LMP6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMP6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="15802" checksum="549FE4C21F93570D" modified="2013-12-11" version="1">MSTEIPKSNFVDPVWMFTDKIFAEPGLYLDPRLETLEARHMIKADKMVLHSPQPITYGPELPPTKYCSYCTPEGGPRRLAYIPRNLRRWKYNLFYYRIFPIDDQRAYGCPPEEYPRRNYEDSEDVVYGPEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN29</accession>
    <name>U4LN29_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN29"/>
    <dbReference type="STRING" id="1076935.U4LN29"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHGHQCI"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21720" checksum="6BF2C1C878660EEE" modified="2013-12-11" version="1">MSRLVLAIGDLHIPDRAPDIPAKFRKLLAPGKIGQILCLGNLTDKETWDFLRGVCADIQIVKGDFDVEATTVPLHKVVTHGNLRIGFTHGHTIVPQGDSDSLLIEARKLDCDVLLWGGTHKFEAYELEGKFFVNPGSATGAISSGWWAEGEDPVPSFVLMDVQGSVLVMYVYQLRKDAKGNESVAVEKITYRKETNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN56</accession>
    <name>U4LN56_PYROM</name>
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        <submittedName>
            <fullName evidence="11">Similar to 40S ribosomal protein S9 acc. no. P52810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN56"/>
    <dbReference type="STRING" id="1076935.U4LN56"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK04051.1"/>
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    </dbReference>
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        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00163">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
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    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
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    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX15850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21963" checksum="E190244DD63EE56C" modified="2013-12-11" version="1">MAPRSYSKTYNIRPFESARLDAELKTVGEYGLRNKREVWRVQYTLSNLRRAARQLLTKDEKDPKRLFEGNALIRRLVRVGVLDDQHMKLDYVLALRVEDFLERRLQTQVYKLGLAKSVHHARVLIRQRHIRVGKQIVNVPSFIVRLDSQKHIDFALSSPFGGGRPGRNRRKKAKAAESKGDEDAEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN97</accession>
    <name>U4LN97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN97"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="17591" checksum="32E281EC4801DD4A" modified="2013-12-11" version="1">MVFSQVLSSPKDSSAGKRKAPGQQEVVVRKKARHNDQVERLRKQEESLKEIMMIHMEGSLERMNIRLETERLKLRSQESRQEYELEEMKQREQEMEKSKQKWEKRKQESEKSHQEFLKKHHSDMQSLARKKAKFDSAMLRTDGDSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNV4</accession>
    <name>U4LNV4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNV4"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="27125" checksum="11558D83506373F3" modified="2013-12-11" version="1">MSVRKKLILRCLGQYFKFSLVVDNCYPISKSPSEGLSKLERHHNEVEVTISALQKMSISVPKEVVDKSEQILEVINLLLMLSTLERLERSELEEQLESEDSNEPRQNDIPSGIPEISGGLNSESYNRKIEDAVESVSQEILEPSNMGLTESVLTPNSTNENDPQETLETSDTGSLELNLATHYTNETDSQEISETSNTTSTCTEENIYLGDMKDGIMYLDFSYQFCTFNKSNIQNEITRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP80</accession>
    <name>U4LP80_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936171">
        <property type="protein sequence ID" value="CCX33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LP80"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10100" checksum="DE4DE5A1DB0FBF91" modified="2013-12-11" version="1">MPMPSRGSVRPSIATAANTKARQYAMLQNQLSSLQWNLEKLEDIMRVTAVQADNIRTLGTLNAALLMSATKIFETQGAGSAGKEKEDDEMTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPM2</accession>
    <name>U4LPM2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936491">
        <property type="protein sequence ID" value="CCX16640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPM2"/>
    <dbReference type="eggNOG" id="ENOG502SAHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5361354at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="39515" checksum="3B5409D2FB7F901D" modified="2013-12-11" version="1">MSGNWFGDQNLGVKYAVVLGALIAVVTTYAFIRLYIQKRRTKKISATLKAKEADIDVERMEQEALTKHGDEEGDLFGIRALEHGFTAGLPQSRPTTPRLPSASGSTLTVNRIPYGKAPSRSTTASTAASMQSTIAIELGNTGGSPPKSTDNLGSSSKSLKNEVDMSMTVPASPRVRPVNEKHDSGPSGSATISNHANKLSGNSEESFDLDYEHGGNLTGKKAPYWKTQDPSASGSGRPGQDIQAPPAAARPATPGLPLQQFLTPQQGRYVPTGSSHSAKSSVSSLDQIEQDHIGLAYPAESAPKNGKGKTRASENSLGDFYDSYYDSRLSSNVQSRPQMRQNPEVVPEIMPEPVNERRFSKMPSRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ38</accession>
    <name>U4LQ38_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ38"/>
    <dbReference type="STRING" id="1076935.U4LQ38"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYYPPFN"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="7">
        <location>
            <begin position="146"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="248" mass="28283" checksum="D4D2A144A26FE784" modified="2013-12-11" version="1">MSDPRKSTKGDKPRKRKRDSLPDSQPKKARIEIQRAPKIENQPYHIVTTSFYLSLAPKYAFHAEKIFPQNISTEDDEAANYMKSLNPKTGIEKHHLDPMLMQFYEPVNGIIIAYNNIRFESQTAKITAEAPYAYVWTTVDLLVWRPRKEMILKGMVTLQSASHIGLLVDNTWNASIPLAKIPNDWKFVENEEAEEEAEEAGLWVDAKGDKLEGLLRFEVDTLKAGGHIFAMEGTLLNTEKIERATLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ68</accession>
    <name>U4LQ68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ68"/>
    <dbReference type="OrthoDB" id="5374395at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="415" mass="46180" checksum="BD5B0C4BF1770048" modified="2013-12-11" version="1">MAPSRPVPTSTTIKVSNRGKPAIYAIHSGPQRGVHLLSSAPLDSSLQYRYRHPINLHRTFLTVSGDFLRRRFDTIEAAIKWIDERDREKELSDRLEAVCMTGTATTTTPTPATTTKQAQAQETPTDATNPVQSWINTTHRAIPNDARVDKLWLAMGNEEIATTVANGDGDDDMSGTISVAATPAQQTGEQSTEQYTEYTLPSGLIVRRLIGHATGNQPQQPPPKEKWLMDRYCPGGEEAEVQVAAEKEKIQAIIEELAELTTEDGAARKETRGQRDREREMREQRKREPVWKHVQVGGIKKVSHASNALQASLASPAELSPTARRGITMDVIAVKGRYSMTHLGARRRELLYSLVVEERDKETIRRQEEQERINRLQLAGIKTGDIVGRLGEMDLEGTRAASMVADDGMEIEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRN9</accession>
    <name>U4LRN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Amino-acid transporter arg-13 acc. no. Q01356</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRN9"/>
    <dbReference type="STRING" id="1076935.U4LRN9"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PIDCFRQ"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="145"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="246"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="36226" checksum="4B2BD7FBDE5015FD" modified="2013-12-11" version="1">MSQERHIEVPQSVVTVPIAPAPLMAEIAPAAMDAPITEATSITAAKDIAYGSLAGMIGKVIEYPFDTVKVRLQSQPDTRPLLYKGPLDCFLQGVRQDGIRGLYRGISSPMVGAAAENSCLFFSYNLAQTFTRSTFYPHLNPKDPLPLSALLWCGSAAGAFASFVLTPIELIKCKVQVQAMESSGSTASKPGPIGVMKEVWKHHGIKGFWNGQTGTFLRETGGSACWFGAYEYVGATLRKRKGSEQLGNGEMMLAGAAAGVSYNFMLFPADSIKSRMQTQVLYPGEKAKGFLEITSGMYKAGGIKAFYRGCGITCFRSAPSSAVIFLCYEKLKEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRS5</accession>
    <name>U4LRS5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Transcription initiation factor TFIID subunit 3 acc. no. Q9P6P0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRS5"/>
    <dbReference type="STRING" id="1076935.U4LRS5"/>
    <dbReference type="eggNOG" id="ENOG502S96D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TDIMIRY"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF21">
        <property type="entry name" value="OS02G0699900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="5">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="15583" checksum="5A355F1095D3F22E" modified="2013-12-11" version="1">MSESELFFSLLRITAAQTLRAAGLTTAKPSVVDAFTDITLRYLLLLGQTTASFAEASGRLQPEVDDIRLALEHVGAIRPVNIFNDPEDEDTRGVDILIEWFKGPQAAEMRRVAGIVGQEAGGAGEEWAGALKKLNEKRKDAGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS38</accession>
    <name>U4LS38_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS38"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="14174" checksum="49E69DE29914B244" modified="2013-12-11" version="1">MNFEGWSEHSQLPILDSSSGPGFGDTRAHVKTYFLLYPQEPICRLPWFKTRPCAGLEKPGKFPPDRNILLPGYLGRESYPALPPHIQSSAITATDDYMHDTVKLMHLYEFIQSYPRYLDGFKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSF4</accession>
    <name>U4LSF4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSF4"/>
    <dbReference type="STRING" id="1076935.U4LSF4"/>
    <dbReference type="eggNOG" id="ENOG502S689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YSYVAPY"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="213" mass="22926" checksum="78C60585935E7765" modified="2013-12-11" version="1">MAPHAETGSPVRSRSSTGNGSAPNSPSLKSFEHLKSFPVVADGINTFSSHPIGQKTIALSTSAYSRFIAPLSPYLSMTYPYVNKADDLADSGLGAVETRFPIVKESTENIKTVIIDSVGYPRKVVAEVIVRGQDFAKEKQQYVFKVYEDEFSRIAGDESSGYIPMAKAGVTSAFVVSSELMGAIANYLGSKKENVKQATKQAKPTNNGKNGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSH3</accession>
    <name>U4LSH3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Probable transporter AQR1 acc. no. P53943</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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    </evidence>
    <sequence length="317" mass="36290" checksum="3E685F5D13EAAB4F" modified="2013-12-11" version="1">MAKKGKKLTRKERKAAKEGENITKKPTDEAEKASKKSPDETEKPVETNDESENDKILHPVDIAHDARHFINEIAGSEKTLQEEYNTEVEFLKSENAKKNRDHSASGDTGQIFEEQIKELKDGFEPGIRAVQDANILKEPLEIAIPLLYDPDYNLFFTQQHLTTFKICIDAARGMASWEIEDAEKRSIKLDQLGTKIYNCITEAMQAFIASCRENELEKMINEGHPIAYEIGLMKVFERVWNGIEPRPTSPEDPARFGSSQEPPSDCFEGQPWALRRNLVSKFVVEKRMEMQRANRDYYETLLSIEEEGVPLSIQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUC6</accession>
    <name>U4LUC6_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUC6"/>
    <dbReference type="OrthoDB" id="5413638at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652385" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="215" mass="23038" checksum="5DDA0A7842FF76B3" modified="2013-12-11" version="1">MQTSQLAILFAALAASVAAFPRAGFPCYFPVAPAAGEQTETADGSPSYAPYKGFNNFHPSSNYHPSLSKPYYYNAYDRQSAAYEDTDASSDNQNANENAMATDNLAGAKSENANENANLAKGGEAFGFGALESDNRNLLANENNIEVANANKNELGVEVANFNANENSAEQESAALAEVMNEDNAEFTDYQENTTDNLNLNDNKNEKARKAGCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUC8</accession>
    <name>U4LUC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUC8"/>
    <dbReference type="OrthoDB" id="5370454at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17699" checksum="DEFDDB81FCBFA4B0" modified="2013-12-11" version="1">MPISSTWRSPRALAGGLFSGIFLLLTSLFGPFILRTIERRHLAAPPPTVVVDAKTEPSPAEIPEPPAKSSPEPVQNEISTERPTPNLYTVPPPELSHFMEFASQFPAPACMLPGPGLDTTGSQRIYKDAVNGQNRMVMEQHHDFGDGRRVRRKVVVYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUL0</accession>
    <name>U4LUL0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUL0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="751" mass="83147" checksum="30859500073AD03A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVE7</accession>
    <name>U4LVE7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936554">
        <property type="protein sequence ID" value="CCX34507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVE7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="29" mass="3098" checksum="08D12A9DC622C9AB" modified="2013-12-11" version="1">MTDMSCQGPKLKMRSASEIAWLTSGAPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVI3</accession>
    <name>U4LVI3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVI3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="268" mass="30292" checksum="3369F45EA592A536" modified="2013-12-11" version="1">MPSKKKSSMAKRKTAKKYFCKWRYIEGCTTTKTKHSELMKHETDKKHKDSVQNVVPRQHLSIGCGDNTCEACGRVFPLQSMLEKHREYKSSITRDCPLHPKHRCHQGCKYLDGSNTDPRVTEQSEGEEGVEEEGVEDKECEGGEDQDTEEERDQVEEEKGEKGGEAEDEGENDGTKQSGNIAEPEQTMSKEVLDAANILFDAFKKACAQEHPQPQGATQQEQASTQSQPIGVLTRATTRRLQQPAEKEAEEQVEERSQLGPRKRQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVI9</accession>
    <name>U4LVI9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVI9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18341" checksum="925874277C793E38" modified="2013-12-11" version="1">MPKRSWITDDMIHEIMRLGKFLGLPAMEELRRLAGYFQFSLVASNCSLLSESHSTVLEKLKKNQQKLNITITTLQEMESPVSPKILEQSEQLSAILGVLGEVEKCGPRIQMLTVGMQQLRTRNKGSGLIARLLLENGANANKQNTAGETALMSLVSGEALIRRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWM8</accession>
    <name>U4LWM8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWM8"/>
    <dbReference type="OrthoDB" id="10580512at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652465" evidence="2">
        <location>
            <begin position="24"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="386" mass="40042" checksum="71F978F170342145" modified="2013-12-11" version="1">MKALTIPSFLFFLLQVSITAVTAESATDVATSPFNRLFTKSSPDGTEIAQPLPTSRPGDYTKIASDADMALLRKILETAKKAELENIRPASSDGVQVTEPREPGESGGTEGSIQPASADGTGNQPNKLETLKPNSPGLLVLTSEEIGPQTQNNIDIFQPSTIYQPDIVGIDPVGVDSSIKGVSVTMQDIATPNGLFVGDDPDNNTGTGSILLVVPASQDEEGVFKLASTDGSTAFGNVTTESESGSLANNEPINESSSPMEPASVNVTTTTQSGLTKIDELITNGTDSSSPVVPASVDEPINTNTTESGTHVSPASEVSTTRSVELTGDYAPKPKKPEGKMTCECTCKFPSGEVAGKKSGGGRNIGPGRMMVPIVTVVVGRALARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUC2</accession>
    <name>U4KUC2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cell wall protein ECM33 acc. no. P38248</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUC2"/>
    <dbReference type="STRING" id="1076935.U4KUC2"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WANNITF"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651430" evidence="4">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="389" mass="40308" checksum="70CA13BE9AC31986" modified="2013-12-11" version="1">MPSIKQLLLAAMVASMAAAACDEDVTIESDGDVSQLASCSKLTGKVTLGKKVTSVALPATLTSITGDVVADGAANLVAFQAPGLRTIGGSFTLKGLIVLSNLAFPELVSVGDINWATLPALQNLGFTKEVSKANSVLITDTLLNTLQGINLKTAERFNINNNRYLRSVDVALTQVSDLLLIESNGKGVNASFPDLKWANNITVRDAGDIYFPKLQKVNSSAAFVNNTFSAADFPELTSVGESFALISCSKLEKITANSLETVGGTFQLANNTKLTTVDGFGALRVVGGAIDLSGTFKEVLLPKLDDVRGGFNLQSTDDVNCGNFTSLKSAGVVKGDDFTCEGKKERAESKTAGLGTDGSGSGDDTSGAVRVGASFATALLAGAVAMFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW85</accession>
    <name>U4KW85_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_05284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW85"/>
    <dbReference type="STRING" id="1076935.U4KW85"/>
    <dbReference type="eggNOG" id="ENOG502RZ0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADPYENT"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="218" mass="24513" checksum="0F26561A0C0B2DAF" modified="2013-12-11" version="1">MSRGGRGGGFGGRGGRQNIPGVSQFGDDIKPDYSVTELFPPNPPPVQSSLTKEERAMVSRFRSHRDKIHTGPFYTVLAPRTKGTTEDPFNNISRYSEKYQRKPRKAPKLDSRPYVVNFFPEELHATLGVEKTEDGKIRKKTLVVTQLDELLDMVDEDGMEDKEDEKEDKEEEDKGVESEQDPDQLTDDDEGDYNAEQYFSGGDDMSDVGGDDDDAGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWH9</accession>
    <name>U4KWH9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative thiosulfate sulfurtransferase, mitochondrial acc. no. Q10215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWH9"/>
    <dbReference type="STRING" id="1076935.U4KWH9"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="54"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17482" checksum="9B22398ECD445ABA" modified="2013-12-11" version="1">MSFRHALRIARPLVRVAVSKPTITNPIVPTIRNFTTSQRLSTTKRYNFASLQSLPSSSILIDVREPSEFQAGAIPGALNLPITSAPEALCLPEDEFVDRFGFAKPPKDAEVVFYCKAGVRSAAAAQLALQMGYEKVAEYPGSWVDWVKRTNEAAGEGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWL4</accession>
    <name>U4KWL4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized endoplasmic reticulum membrane protein YGL010W acc. no. P25338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWL4"/>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQFIGHY"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="21373" checksum="8CD78AD7F8606364" modified="2013-12-11" version="1">MFLDLEKHLVFYGTYHIHPRNVAIHIMFVPVLMFTMMLWASNVALPVTASFVPPEYLNLSTLTSVIYAIGYVLMEPIAGGLLLPFVIGQSLAGTYCVQHYPGANKWAGIIQAGSWIAQFIGHGVWEKKAPALVDNLVQALFLAPLFVWIEVLFKFGYRPELRKRMEAQVKIKRAELDARGKKGAEVKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXB8</accession>
    <name>U4KXB8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935278">
        <property type="protein sequence ID" value="CCX05981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXB8"/>
    <dbReference type="OrthoDB" id="10479093at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15623" checksum="68DE6884C43EE3B9" modified="2013-12-11" version="1">MSGRFTPTSESSAADNQTDIPDASIGTFVINVLCDNPKFNEDVLVIVDEESGIDKATEEFRDNITRIAQKASCICRYWFLEVRLFIPDDDGNGSIIVSTRQLMQMIWCLPRAPGLIKPRFFSKPNSNRIHVTLKKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXV9</accession>
    <name>U4KXV9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935310">
        <property type="protein sequence ID" value="CCX06756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXV9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6993" checksum="B228D26FF52F4557" modified="2013-12-11" version="1">MSNTHCGCTADMANLLLRYDLDVPVHTDRSVVDAEYMQLIRCINQRIKSTSKSETTRLTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY57</accession>
    <name>U4KY57_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935320">
        <property type="protein sequence ID" value="CCX06896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY57"/>
    <dbReference type="OrthoDB" id="10527608at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="112" mass="13099" checksum="0BEB8FE3FD123692" modified="2013-12-11" version="1">MCEFCPPPDRPVPVFINTVNGASIQARWERDNGLPPPLSRREKARLMRDMQRRRARRDLEANRSPEEKKRRNRRQNILLGIMALLIVIAMIVVGTQWLKKEAEKTKQIKAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY74</accession>
    <name>U4KY74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4531" checksum="8552098A994A3AAB" modified="2013-12-11" version="1">MLHLNLNLSVGWYSSNCEKNSKLQTIEAAENLQLWLLKK</sequence>
</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="EMBL" id="CCX08191.1"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            <begin position="1"/>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07400.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="1011" mass="111711" checksum="6BB5F418926AD295" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4L1E5</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <strain evidence="9">CBS 100304</strain>
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        <property type="project" value="TreeGrafter"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CCX09682.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="436" mass="49155" checksum="66183EEE2F70CB2B" modified="2013-12-11" version="1">MNTINIRRDVADPFYRYKMERIQSKIEGKGNGIKSVIVNLSSIAHSLSRDPAYVVKYFGFELGAQVTAQPSDDRYIINGAHDAAKLQDSLDGFINRFVLCAQCKNPETDLVITKEGRIIRDCKACGRTTDVELRHKLSSYIIKNPPKKVKKEKKEKKEKKEKKEKGSSKSKKSKKGEDDAEEADEDLALEAGSDDELFRRINAEAKELSIQDLSKEIEDDWGLDMSPEAVAARAASGLAGAHAKAELEESPYDILGQWIIDNKDEDGNIDCDKVLAKATELGIDRKHKTLQVLAQTLFDKNIEEQLSTRSYKLLLRNVMRPDKKKSSEKHMKAFVGGIERFVGIDQPELVKDISKIGGAMWTNRIVKKNVLIAWSSKSGSNKYVDLAISKNIHKNTDLLLRSLKAVEESDDEEEWEIESDSEDESEEDDDDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1S7</accession>
    <name>U4L1S7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX10020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1S7"/>
    <dbReference type="STRING" id="1076935.U4L1S7"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="595"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="724" mass="83049" checksum="91F85CB8C5978FB4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1X5</accession>
    <name>U4L1X5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative uncharacterized hydrolase C7D4.05 acc. no. O14262</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935429">
        <property type="protein sequence ID" value="CCX08743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1X5"/>
    <dbReference type="STRING" id="1076935.U4L1X5"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="394" mass="44482" checksum="4EDFB197427B0F36" modified="2013-12-11" version="1">MPRVASRRLQRSNPDTTTMQKPRKALLVTFDAWKTLFSPKAPIAQQYVEVARQHGVVADEAVIKKSFSEAFTTLSHTHPNYGHTTGLHPDAWWTHLIHQTFSPISLPPTLAPALLSHFASSSAYTLHPSVPYLLHQIRAAAGRGKYDKVILGVISNSDYRVISILRSLGVGVRDQDPAMRHSVYTGDQENGLIDTVTLSYDVGVEKPHPRMWLVAWNKARAMERNRGLWWDRVHVGDDREKDFEAAKEDKKRVLGEILGEEEGTEIWRPGMGVQEVGEEKKDMIVGKQTRERSWRSVVDKKEGGGFWKNLETAKEDTEIIDNKEDAEVVDTTEGRGSCKTLETGKVAEEVVSKKKDIIFAKQRKILGTVKEDESLVDNTLILLMIQRKSILHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2A8</accession>
    <name>U4L2A8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 9">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 9"/>
    <dbReference type="EMBL" id="HF935540">
        <property type="protein sequence ID" value="CCX10411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2A8"/>
    <dbReference type="STRING" id="1076935.U4L2A8"/>
    <dbReference type="eggNOG" id="KOG4064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YTENQVT"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="7">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX10411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="243" mass="27067" checksum="A96E40E252E31EEC" modified="2013-12-11" version="1">MPIPHPPSPTEKKATLCTRIPRGELCRTHSNPNLKADDNRFLSLRDEINRILGPSSGIDSSDVSVDEIMDAMKQYISSEKDWNSFALSDPSRNYTRNFVDHGNGKANLLLLVWNPGKGSLPHDHAGAHCIMKVLKGSLRETLYNIPEATAENKQQPLSVRKTTVYGNDEVTYISDDIGLHKIENASSTEIAVSLHLYTPPYAEKNGCHAFDVKTGKKTKVEMCTYYSLYGQRNVTQEAKGRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2B2</accession>
    <name>U4L2B2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2B2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="226" mass="25656" checksum="DA135746CCB2E360" modified="2013-12-11" version="1">MEYALLHLRHLATMDQATNMDGDQIFVDESQQEESEQIIADDSCAGNIATDNEKDSGDSSDVKSSSDDEAGTDGDSSDHNDDVYAHSNSSDHDDVFWTDTDFSDDDDDGVTDELDDIPSSYQLPGSESLRHYNIRHALPNFETEEEFHVWVLTNLHWIHCSPLHTALRYSNWARLRSQSDDPRDGTFNIDSLHEVLDEAIDEVTRSRSLCCLIHDRADVWPWSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2J4</accession>
    <name>U4L2J4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2J4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15899" checksum="642B99D3C2313170" modified="2013-12-11" version="1">MLGALDLKAIAARKLENQLKQWNSEEFIRCVQEVYDKTSKTDLDIRNMLIYAATSNMAEVMKFGSFCKEFERYGEFTSPLILNFHSHSAKVFEEMTSSHTAELQKVKKETKEESQSLFLKISHEKPLERPCTASQANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2L7</accession>
    <name>U4L2L7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PEP2-like protein NECHADRAFT_97050 acc. no. C7ZKL5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2L7"/>
    <dbReference type="eggNOG" id="ENOG502RYCB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TGRFYDF"/>
    <dbReference type="OrthoDB" id="2533647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="233" mass="26902" checksum="0275796BF0D65834" modified="2013-12-11" version="1">MPDLHSLPAGSRPENAIRNNGPDDLALERYKLRELAEGWPCYRDACEWENFKSIFHYPDAFVYTTWTGRTPIADFIAASQGGMDRGAFIMHRIHGTTTDIQGNRAVTKMKATITQRFTIDGCEVDAESDCRFCFLFEKRGDKWGAVFVRHWYEKDKLIPVDPRKIPELDDEKLKGFPKGYRYLAYCQEATMGNIKVKLDMPGHRNEADSVTGKEHDKLYWQAKQWLEGEEVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2V3</accession>
    <name>U4L2V3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2V3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4569" checksum="BBF5776C5ABF0B23" modified="2013-12-11" version="1">MDSHQLRQLKHQHKVLITMYINDNRIHSRVAVGSEENAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L303</accession>
    <name>U4L303_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Peroxisomal membrane protein PMP22 acc. no. Q9ZS51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935568">
        <property type="protein sequence ID" value="CCX10847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L303"/>
    <dbReference type="STRING" id="1076935.U4L303"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYGYQWL"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32030" checksum="2DBFF51A27BD3AC6" modified="2013-12-11" version="1">MNNETREIIRRETKNIVSSTGRNGGIRSPSYIQVYLRELQENPLRTKMLTAGALSSLQEVLASWIAGDRNRHGSYFTPRVPKMAIYGSLISAPLGHLLVTALQKAFAGKTSTKAKVMQILVSNLIVSPIQNTVYLACMAVIAGARTIHQIRATVKAGLMPIMKVAWCTSPIALLIAQKFLPPHAWVPFFNLVAFVVGTYINAGTKKKRIQAIKKKKVREAALSQSHIAENSKSYSASTSLHGQNFSQTQSQANLGHRISHTSSEMSYNVNGTKQYYDSKGDKRDYHVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L371</accession>
    <name>U4L371_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Maltose O-acetyltransferase acc. no. P77791</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935501">
        <property type="protein sequence ID" value="CCX09973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L371"/>
    <dbReference type="STRING" id="1076935.U4L371"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYSGTHP"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX09973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="232" mass="25195" checksum="9DF5B7066E1BED85" modified="2013-12-11" version="1">MATEKEKMLRGELYHAFESELVAERARCAAACAAFNSAGDAPRTERIKLWNAITNTPYNPEASEDAQPWIEPPFRCDYGYNISLGPNSFVNFGCTILDTCKVTIGARTLVGPNVSFYAATHPLEAEVRRGTEGPEAGKEITVGEDCWIGGMATILPGVKLGRGVVVAAAAVVTKDVEDFCVVAGNPARVIKRLKGSEEGREDTTSTKALLKRLEVLEAEMKEVKEKLVERAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L394</accession>
    <name>U4L394_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_06370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935312">
        <property type="protein sequence ID" value="CCX06783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L394"/>
    <dbReference type="STRING" id="1076935.U4L394"/>
    <dbReference type="eggNOG" id="ENOG502S6TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFTPGIF"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651861" description="Protein BIG1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="246"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX06783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="296" mass="32777" checksum="A908321A043BCD4B" modified="2013-12-11" version="1">MRSIFLSIALAASVHAFSDTSPYILVSSSSGIPDAPRTHRILSSTTFVQAAKEVVTRCDADNYILVSQPGLHIEDLAQPHSGVHLKDLLSSVDEEFKWVASNVFVPSVENDMGSVIESLQHDVVEKCGARLMGVDAKTGSLSLHADEGKRPRILRVDFDRLPQEGQKRGKMVEQHDAFLHSVLDLIGRGKYTLVYASSPIAAEKQVKKTTQEKVEEIWQELELRSVLEEGQPKRNETQGGLFHRYQFFTPGIFMGYIAFFVMAGIFYVGLSAVSSIKVSYGSFDKDMGPAAQKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3B1</accession>
    <name>U4L3B1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935547">
        <property type="protein sequence ID" value="CCX10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3B1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="111" mass="12801" checksum="F3FB9A4FC03C090E" modified="2013-12-11" version="1">MTIFNPKFLCGKPKQKKPTELKIRKRVKLVSKLVTAIHTIDVWTNQMAKLKEGKIHDDDMMYSYMTYRGFQGDMWERMGGVWGEKEEKEGMEGTEGKKGCDKYDGCEGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3F9</accession>
    <name>U4L3F9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Ankyrin-2 acc. no. Q01484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L3F9"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
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</entry>
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</entry>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="642"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
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            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
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            <begin position="301"/>
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        </location>
    </feature>
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            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111765" checksum="BB432B244C9686FD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="17106" checksum="1009D51A92C5FC6D" modified="2013-12-11" version="1">MSRNSVPHFETIPESDLEHGNDRAGSVAPIVLASAWERHMAYSSATDSASTLVDSVQDNAAVQIPTADVFYVATTDNRNVDDGQRPTTQPDLPNVETNKKKHPSGCKLCCRACCGETKIFIQSWWHIGIVLGCITLVAWLFKTFVIGKPYELRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7L5</accession>
    <name>U4L7L5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Lon protease homolog, mitochondrial acc. no. Q4X0Z7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12213</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935721">
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    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L7L5"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9491" checksum="B48765EF92187A82" modified="2013-12-11" version="1">MHQGHLILLCNYPATRVMAIAEKYLAPQAKELSGLKDVDVQLQQDAIEELIRPYCRESGLREDLCEPVFRDPASRETYRCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7Y4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7Y4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9733" checksum="561229F1C34032F7" modified="2013-12-11" version="1">MKSIRTTQRLFGAIRYKTTVAAMPVEGAGMARATAARQAQLKGINVAFQKSKSAYVTFDKWRSKEAVAEEEMLRRAEESARMPNHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9A2</accession>
    <name>U4L9A2_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_01223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX14997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9A2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9484" checksum="A9C0F24D69229A25" modified="2013-12-11" version="1">MNLYIEISRSVDCISSVIIINHGQYRVVSTIGTLAVPILHHLHLSTSNFPSVSLSAATHPHPSSEGRLVSVGTHHRMTKAPNLPYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9M1</accession>
    <name>U4L9M1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9M1"/>
    <dbReference type="OMA" id="SHAFCAF"/>
    <dbReference type="OrthoDB" id="5397275at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="324" mass="35391" checksum="997D1E81A47AD25E" modified="2013-12-11" version="1">MSTAVAFSSPRQMQENTRPSPARSISPPSSPSRRHKHASQDDSEDGYSSHPSIYSASPVGSDSGNEAPRDPTFDNLNSPESVFALTLSSESHRRRNTRGNGHNTVNYHTNGDANSDTNRNQDFSGLGFLDTITEQKSKTTLEVHEDLEELEELDNDQDNSYISDESEYGEQMFYDCASPTQPLHPRMSSLPNAPLLSNPSSPFTVDPTHAALQTFFSHSPGHLSRTLPSSHGQRPQAFRAPTSMNRSYGTLSSHPFHRAPVAEAGAVLNRMPTPDRLDSPLPRERGTGCWGRLWRGVVGVCCCLPADDRIGSASVSGSTRGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9Z0</accession>
    <name>U4L9Z0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9Z0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="131" mass="14689" checksum="1AD282F42583BEA2" modified="2013-12-11" version="1">MELSPAPHRSPNEPDGAELCPRYVAPPPPYILYYPAYSTHPAYASPQPTHSATIPYSSLIENADSSCPLPPYSPPDPELPGYSPPISELIYQVFIPYICRLIVSAVAVFCIYVIVNWAVVVILLRFWYFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAB6</accession>
    <name>U4LAB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Lymphoid-specific helicase acc. no. Q9NRZ9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_06686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAB6"/>
    <dbReference type="STRING" id="1076935.U4LAB6"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PNIFTDW"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="200"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="604"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX07099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="822" mass="92122" checksum="56CC44DD5BE6011E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAX5</accession>
    <name>U4LAX5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 37S ribosomal protein S19, mitochondrial acc. no. P53733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAX5"/>
    <dbReference type="STRING" id="1076935.U4LAX5"/>
    <dbReference type="eggNOG" id="KOG0899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14961" checksum="9AAAF0E5FEF3B7AA" modified="2013-12-11" version="1">MQPTRALFKRSVWKAKNEKNEAGIEVGTEVLRRETCAAVAANLSSNAPAANQNLRWPFIVPMPIVKPVPGVKQVPIKTQARSCTIIPSFVGHKFQIHNGKSYIDVTITEDMVGHKLGEFAATRKNFTYKQTKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBZ2</accession>
    <name>U4LBZ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBZ2"/>
    <dbReference type="STRING" id="1076935.U4LBZ2"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX07832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="33339" checksum="9DCEA9F032C78FDA" modified="2013-12-11" version="1">MGWFWADSPSTPAAATPAAAPPAGHPTAGTPPPSCPMHKPDTSVPAVTPPSECPYTPEQAKQAADQTMNPLNFMFSNLPQTRAPGQKTVLPTEREISSIPKGDGGNWEYPSPQQMYNAMRRKGYEDAPEDAVESMVAVHNWLNEGAWDEICAWEQKFGSGVLGYMGLRESDKEWKPRLARFQGRRNDPTPKSQIYGFLGRLMPETFGGPPPFDRHDWYVLRKFPGEAEPREVRYVIDYYSGAPEPTGEPVFFIDVRPALDRPGLMMERIVNWTSETWDRASGMDVRRAAQAEAKRNAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC58</accession>
    <name>U4LC58_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to mating type protein MAT1-1-1 [Tuber melanosporum] acc. no. ADU56595</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935381">
        <property type="protein sequence ID" value="CCX07902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC58"/>
    <dbReference type="OrthoDB" id="10415284at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="38771" checksum="604A66240BA4D496" modified="2013-12-11" version="1">MIKLRHSLGTFTEILACPRPTYINNWHVLSFPHSTADNFANHQRGPVSHPPPQSRQQNTRQKNTLHQDITNKMNTIPVNLSTVVEDAPPMAVTKFTDPFDYALAMRRAVYGAARYLDQEFNYAVLQDKMGRIWTQLTDNMIIPIGGRRIVVSALTYDQPQDWLDTIIREVRNKGRNSLNCNFPYAIGVLALYEGIAPSKFPESLIPLYLQTGHGPNRVTPHLKPINAWMAFRSWFVDGLKANFIIGQSDMSRIAKTCYGEGRLPDFVNIAHMYTHARNRDALGGMSLCDFIKKELKQYGYRKTPLSLIAENRVDMKAYPLRRNAPLADEGLRLVKLPKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC74</accession>
    <name>U4LC74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized transcriptional regulatory protein C1327.01c acc. no. Q1MTM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC74"/>
    <dbReference type="STRING" id="1076935.U4LC74"/>
    <dbReference type="eggNOG" id="ENOG502QR2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAMARHV"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
    <sequence length="2053" mass="224367" checksum="F50A3E2FDA8A031F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE68</accession>
    <name>U4LE68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935358">
        <property type="protein sequence ID" value="CCX29807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE68"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="18353" checksum="2E33133EB64645F3" modified="2013-12-11" version="1">MCKRYYPLYICGHVGVGDDIWGSRCNNHLSSQNPSQNPFSSQPPQSSPSQPSQPSLGCSLIGTSPVSLLCPPCNYHERRLRKERIQRANEENERRNREGVLLGLWRVWRAWGVLLEVMVWRDSLGIEGMEKMEKMVDMGECRGWNCIGPGLGYRGGDSREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE78</accession>
    <name>U4LE78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE78"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="10161" checksum="3B6129BAB95EE898" modified="2013-12-11" version="1">MVVSKEVQRRLLKQRARACRQGNNDRTSLEPPSWLHPLRHRPVRRRPLWHKNLHRNVTELSTLPAEAAHRTEVSNNGKWNSKVGEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE89</accession>
    <name>U4LE89_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein FPV162 acc. no. Q9J569</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE89"/>
    <dbReference type="STRING" id="1076935.U4LE89"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="282" mass="31269" checksum="81D66C77737FC6FC" modified="2013-12-11" version="1">MLLSLDDRYDDPGQEWYDQHYEGFETMVKLLLDHGAALDIRDLYHGTPLQCAIRRIGGKHVHGNSLVRLLLDHGASAEESENVGGGHIPLQAASYWGTLEVMQTLLEYGAAANRRRDFNNEELPLNLALMSGAAEKKERVMFLLEHGVYVTLRNFAGETVLHILAEDCPDWLEGVELLVGLGADINAEDTAGYRPLHCATESENLGIIKTMLKHGANIDDRCRAEANGTVLHLAVSERSDGECAKFFLVKGLSVDTQDNSGNTPLHKAVEWDTWINIQPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEF3</accession>
    <name>U4LEF3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEF3"/>
    <dbReference type="STRING" id="1076935.U4LEF3"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX29917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="35949" checksum="23EADAC54E25B834" modified="2013-12-11" version="1">MLSFRTTGFNGYAVKYSPFFDSRIACAASSNFGLVGNGRLYILNLTPQGIVAEKWFDTQDSLFDVTFSESNANQLAVASGDGSIKLFDATLNDFPIRQWREHTREVFSLSWNLVDKNIFASSSWDGNVKIWNPTAPQSLRTINIGSCTYSVAFQPSSPTVLSAVSSDGFMRVFDLRAPEPSAEIAKTRVSPGEVLTQDWNKYRPSVIATAGVDRSIRVWDLKMPSMCQTELVGHEYAVRRIAWSPHWQDVVLSASYDMSVRVWTDGSAQAGGAGPGTGRLLGVMDRHTEFCAGVDWCLFGGEGWAASTGWDEMVWVWDVGSTMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF25</accession>
    <name>U4LF25_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein RCR2 acc. no. Q03446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF25"/>
    <dbReference type="eggNOG" id="ENOG502S8F1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FNTNDGY"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="21771" checksum="AC9D13528088C7F8" modified="2013-12-11" version="1">MNNPQYDQSITCDSWGNCYSSRWNNWGRWVFVTFVIIGFIMFITMLMFISARKRRRIGQQPLVGTAWLAPKNQHPQWNAQPGPSGPSGYYPPPPPGGDYNHGNFYTPPPYTPNPQFTGTTPDTTHAGAYYAPPPGPPPVHTTGPAYEMTQQPNHQGPAPPVPVNSHPTGTSTHSYVQSNNPFQPPASPPAAHIGPTGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFB7</accession>
    <name>U4LFB7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UPF0656 protein C926.02 acc. no. Q9UUG6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFB7"/>
    <dbReference type="eggNOG" id="ENOG502RZIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRFFMRA"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="467" mass="51620" checksum="DFC87CDFE8A779B2" modified="2013-12-11" version="1">MPVPKYHQRRFHTNSKKHKKVPETAEDFLEAGIEFEESGDRWKAGDRQKAARFYRRAIEQYEQCLKIDSTQFDAAYNKARLEYKLTQEPEMCTKLELLPLLETALKSHMEVLGIERENLDAIFNTAQVHTSLAEQLTDLEKPRAVSLLNTACQLFQEVLSKQRAKFASYSSVDAIDTEAGGVSLAGVDDMMIDDDAETSAQTPSSTKDETDDNEEYAHIEVPVTESTILDTHLEFLATLCTLLPLNPSPSLLQTTSDILTSTQSFSTSLPDRAKEITLTSYQVHLAAAECQFRLGMHTAADWAATISKAFPTGLKTAEAYSIKSDAHITLASEVSEMAFAHLSFASAALKEASKIQQTAGNVYLAWGDVELMRSRVAPEAHRITLKKNAGVYYRAAMKLGDATEKFEAMTKEAFLKWGEGGGTELLRSKAAQEVIAEAVEEGVIDRDEAVCLAGVLRAQKEGMMAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG02</accession>
    <name>U4LG02_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG02"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="5013" checksum="A5EDF90E15A7402C" modified="2013-12-11" version="1">MPVMRNQGISILRLHFVFDIQVLLPQSIVFDVRVLLLRASYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGJ9</accession>
    <name>U4LGJ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein L93 acc. no. Q5UPG5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGJ9"/>
    <dbReference type="STRING" id="1076935.U4LGJ9"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="666" mass="76717" checksum="7F93E87029F1CC95" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGK3</accession>
    <name>U4LGK3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGK3"/>
    <dbReference type="STRING" id="1076935.U4LGK3"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ILETAWI"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="2">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23923" checksum="26684FDF5D41E9DD" modified="2013-12-11" version="1">MAAMELDDILGEFDAGAPASNPGKDISDLTTAWIAERTAPEILPFQTQLVERLTDRIRQQIELVETETGNMDPAANFRLILIQTELERVKYLIDKYGLHVLSNNAVRANLASSELAYLKSHLALLNNHYLASFLRNFPEPLRRLDDTAGGLTMIEEPDMESAVFCRVVKEPIDGTVRIPGTDTEFELRKDDVYVVRYSAIRQWVMTGEVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH15</accession>
    <name>U4LH15_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935597">
        <property type="protein sequence ID" value="CCX11214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH15"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10376" checksum="B3282F1F2211DDB7" modified="2013-12-11" version="1">MESPLASSDTEMDLTLDNTDSLTPAANPNNPTDPAWLHHDRNSINPIHDSTHNDDTPQHATPDQPTGHDNQPADPVTPFRGPLPIPPLPPHCPVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHX7</accession>
    <name>U4LHX7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHX7"/>
    <dbReference type="STRING" id="1076935.U4LHX7"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="387" mass="42928" checksum="CF6316A7F5C925D0" modified="2013-12-11" version="1">MSTTSPVPAAAEPIASPAKKQPVNIVCIGMAGSGKTTFMQRLNAHLHAAKEPPYIVNLDPAVKNVPFDRNIDIRDSVNYKEVMTQYNLGPNGGIMTSLNLFATKIDQVIGILEKRADSLTRVLVDTPGQIECFVWSASGAIITDALASTFPTVIAYVIDTPRTAQPATFMANMLYACSILYKTKLPMILVFNKTDAHDAEFAKEWMTDFEAFQTALRASEENGDDEAIGGSGYMGSLLNSMSLMLDEFYNHLDLVGVSAMTGAGIDEFLKAVDGKVEEYEKDYKPEMEKARAKREEDKVKNKQKELDRLMKDLAVGKKEEQADVISDLDTDDEDNQGMVERDEDEVVNEQDEETLQKRYEKALGDSGSRSTKEEEESLQRYLQKSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHZ4</accession>
    <name>U4LHZ4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHZ4"/>
    <dbReference type="STRING" id="1076935.U4LHZ4"/>
    <dbReference type="eggNOG" id="ENOG502QU2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IRTLEWE"/>
    <dbReference type="OrthoDB" id="5395440at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="828"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="405"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="910"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120160" checksum="82B981E858AE00DF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI62</accession>
    <name>U4LI62_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_10353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="4">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI62"/>
    <dbReference type="STRING" id="1076935.U4LI62"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="16785" checksum="5E8AE08BA3F1F49B" modified="2013-12-11" version="1">MSFRIATRLAGARFVAPRAARTFATTPRVNVVIKKYTQDHEWISLDTEDASKIATVGITSYAAQSLGDVVYVELPPLTSPVLAGEPFGAVESVKSASDIMSPVAGEVVAVNEALNDKPSIINASPEGEGWIVKLKVKSLEAEGLMEEAEYKKFTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIR5</accession>
    <name>U4LIR5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_11452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIR5"/>
    <dbReference type="STRING" id="1076935.U4LIR5"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRFCMIC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="135"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="513" mass="59605" checksum="F9995944C1DDD093" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIX3</accession>
    <name>U4LIX3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to DNA-directed RNA polymerase II subunit rpb4 acc. no. O74825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIX3"/>
    <dbReference type="STRING" id="1076935.U4LIX3"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRKTQNE"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="15805" checksum="153A715C5F87B9CE" modified="2013-12-11" version="1">MSALPRTAREKEHTLGDEEAGTELKLGEFEHATALTLSEARALMNVIFEHRKDVGKVVTKTQSYLEVFSRFKQQETAQAIERILVQQTDLTSFERAQLGSLCCDSAEEAKTLIPSLAHKRTDEDLQELLEEITRLRQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIX6</accession>
    <name>U4LIX6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative methyltransferase-like protein C27D7.08c acc. no. O42662</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936499">
        <property type="protein sequence ID" value="CCX16689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIX6"/>
    <dbReference type="STRING" id="1076935.U4LIX6"/>
    <dbReference type="eggNOG" id="KOG2912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="312" mass="35177" checksum="68DC05CFFF51203A" modified="2013-12-11" version="1">MYATEIDSHSYAFAETNIESNHLTHRINLRQPSSSTQLLPSDLWGEQNIDFIMCNPPFYGSFAALEAATAAKTAPPNSACTGSETEMVYEGGEVAFVGRILEESLALRTRVKWYSSLFGLRSSVDIFIGMLKEKGIENYTATEMHLGKTKRWAVAWSFGDRRPVVPGLQGCYPHGIRGEVEFTVKNEGQEEMVQSLLKDGGFLLTTLKSRPRVWYGEVREDTWSRAARRKKARDRAAGMDMDQQFITDKKGNGEEVCEYPSTYNENGEEVFVGMGFTIEVVEDKMKIIWRRGDGKLFESFAGMVKRKLTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ24</accession>
    <name>U4LJ24_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_12025</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ24"/>
    <dbReference type="STRING" id="1076935.U4LJ24"/>
    <dbReference type="eggNOG" id="KOG0210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IAITTWH"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
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                <person name="Kumar A."/>
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            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935720">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJD1"/>
    <dbReference type="STRING" id="1076935.U4LJD1"/>
    <dbReference type="eggNOG" id="KOG2265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="21"/>
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    </feature>
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            <begin position="22"/>
            <end position="34"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="206" mass="22988" checksum="08097DA84014028C" modified="2013-12-11" version="1">MEGHKSNAGTGQQTNQSSLTMSASDAPDPVADAAARAKEIAEQATLPYVWKQTIGDVDISVPIPAGTRARDLDIVMQSKKLKVGLKGKEPIMEGELPKSIRLDESTWSVEDQKSIEIHLEKTNQMEWWPHVLTHHPAIDTSKINPENSNLSDLDGETRAMVEKMMFDQRQKEMGLPTSDEQKKLDMFNKFKAQHPEMDFSGANLSM</sequence>
</entry>
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    <accession>U4LJU4</accession>
    <name>U4LJU4_PYROM</name>
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        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
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        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="313" mass="34046" checksum="6AD7D4EA062BAF67" modified="2013-12-11" version="1">MPRILSQHQTTMTPRRKPEASSENAVVIAHHIPAVYNKELALDAPTKSPMKRVIDGRITKARKEQILVNLETELNERIRKLRAQAQTLSQSLAVRIGSRINRVPKKFWNMTMGELLAATEGEAGKALGDVGGVRGFVNDVRRLSNGAPQSPHKLDSLATLKKRQQKTFSSSNPSYPHPSPQKSPQKNPLILTNKSNFPPSGTPLRAASPQRSTSPTKLSKPTGTGARKRAPGSRPQSRANGRTSVETAGTVASTKGGMKDKEMKRPGTAKSDKGGNKEKKMMGQQKSDGSLKENKKVGGEKTSRGGRVLRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKC0</accession>
    <name>U4LKC0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein MGA2 acc. no. P40578</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LKC0"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="entry name" value="IPT_dom"/>
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        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13857">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1371"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="7">
        <location>
            <begin position="346"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="7">
        <location>
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            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="834"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1006"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1071"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
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    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1172"/>
        </location>
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        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1441" mass="157301" checksum="D3196303CB54401E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKF8</accession>
    <name>U4LKF8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKF8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9464" checksum="4B5526F7340C5A47" modified="2013-12-11" version="1">MKRQDLKVLQEEIQMARVDVSGVHHVKTGSPLRILRRLTQGTRFSVVSRHRFLFRGCIGRTRARPFDTFKDERRKAESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKR2</accession>
    <name>U4LKR2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKR2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651445" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10920" checksum="395DA3EAE88476BC" modified="2013-12-11" version="1">MTYAIARLFMRLFFIITVASITSSKKPAKLAALLECRRIILDAEADPTLQVTDQSGHCIFERRKIYPQCFDILENCTKVKHIMQYIFNISKTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLW1</accession>
    <name>U4LLW1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLW1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="13162" checksum="59DE028B81C91878" modified="2013-12-11" version="1">MGMRWHPILVSSGKATAVSLKCKVWLLARWILQKSTPNIGLFTALTQTCRSTNPCCRFQRSNPPFPSLLLPVEDLRIGFFTVGINSPEERGRIDKEMENNIEALAALFSLLAMRQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLY1</accession>
    <name>U4LLY1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to ATP-binding cassette sub-family A member 7 acc. no. Q91V24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_08537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LLY1"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKNWIVL"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="455"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1239"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX30340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
    <sequence length="245" mass="25695" checksum="82131E600C74CFBB" modified="2013-12-11" version="1">MQCFGCGPKPDTPAPAPAPAPAPAPTPAPTPAPAPAPAPAPTPDPAHPPAPAPGATAESPDENAAANGTDTATNRLGLGNVTDVDVPKSPCCCGFWNLIHNLESTKTGRFFLCFILALVSVGGVIILFMGIFIKSFFKDCNHMDAPIQAGVIILRIFLILLGLSLMIGSTLLWLLLLSKLSIRDDSKKADHEALGAAGHDHSALGSFGMHLPHWFPGRVVESDEGSVWHGHNHRSRNYSGMHGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMS5</accession>
    <name>U4LMS5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936061">
        <property type="protein sequence ID" value="CCX33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMS5"/>
    <dbReference type="OrthoDB" id="5465229at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="244" mass="26686" checksum="A10AB70E163711B5" modified="2013-12-11" version="1">MSSIVNNATIVNASIIGNNNNQVAMVNASIVGNDNDQTAMNKFQVAMNVAHMGSLYSLIATAAPHPNLPPSFTLHKNVPIELQGMDMAPAYVGASTNEPNTSANSVPSGPMKIKLASPSIARPIPIARRAYVDTYVAPSVINVRMVFKVIRPNADLPHGKSEIRIFPGNGRSHLIAVDDDVVERLRLRTMHEPLKKKLVKKMENERVGRPTQKPLTPRKVDRLDSRSKAMRSKKVQRRAGMISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMT0</accession>
    <name>U4LMT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936082">
        <property type="protein sequence ID" value="CCX33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMT0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652483" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8343" checksum="F2CAF6739EC156FE" modified="2013-12-11" version="1">MELSIIFAAVFSAVVIASAVPNPDAVADDSDVFQLEKRRDCYDSGCGNPCRQGYKIEKATICGSPGRVPLFNRVCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNE4</accession>
    <name>U4LNE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_09441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNE4"/>
    <dbReference type="STRING" id="1076935.U4LNE4"/>
    <dbReference type="eggNOG" id="ENOG502QYA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKWYTQT"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652503" evidence="5">
        <location>
            <begin position="19"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="687" mass="75054" checksum="57BC05F18A9507C9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNF1</accession>
    <name>U4LNF1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNF1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8472" checksum="31E6417517361584" modified="2013-12-11" version="1">MRRITKLDAKRAARRTWELPGNLSGNLGACTKDNPRKREPFFLAISSFPLEKPRKPRRDVSSTSSTPFICLTAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNG1</accession>
    <name>U4LNG1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_14172</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNG1"/>
    <dbReference type="STRING" id="1076935.U4LNG1"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHDCYNW"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
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        </source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33132.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="637" mass="68166" checksum="962D6057EA2DCD40" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNT1</accession>
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        <name evidence="2" type="ORF">PCON_09666</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </feature>
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            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX30990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="179" mass="20197" checksum="A7F5526CDA32A78B" modified="2013-12-11" version="1">MDGAEKLEKKYIALLEGKISSLEKELAEKSKNDSKKAPQENTKGTSTSNRIKDGETPAVKKKSRVRYLIRSYTETGEFTTQPCEEEPGKDGALSNEDSDELAISWRHTYEEQTGNGEKKRKFSFKELVIESTELKKALEEVVTKKYKDMSFNRNETSLRMHLSLPEGIAGVCGSTNRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNV6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Similar to GTP-binding protein 2 acc. no. Q9BX10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01504</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5342685at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF30">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
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            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="951" mass="102439" checksum="29174AEABEB87256" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP31</accession>
    <name>U4LP31_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Zinc finger protein C25B8.19c acc. no. Q9UTA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP31"/>
    <dbReference type="STRING" id="1076935.U4LP31"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX16344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="342" mass="37300" checksum="F95F0C7365C36DCB" modified="2013-12-11" version="1">MALDAQTRPQQSQMHFMSPDQVPQFTNPWAQEQMNDAASLHHSLSKPPTIRTTDVSAPFMSRTAMASGHMRHLSSQPGNYPNPNGLMPTVSNVGLPAFTSAEMSMAGSTAPSLTAVAGATYMPSFSHFDNTPRTLIPSERRLSQPAMSSSLFLSADTVPKPRQASLTDISYRARPDLDFTSGGMDTRGLAFGQPRQRQDSTSYQSSHSASSSVSSTHSFPYYHGGSIDSSATDYSDGTGYPQERAGIVRSSRPGGYLNNGATVPNQMMTTFSSKITSSTQKKHKCKVCDKRFTRPSSLQTHTYSHTGEKPFACEHDGCGRRFSVVSNLRRHKKVHQGKKHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPN9</accession>
    <name>U4LPN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="12125" checksum="6BF6A550E3999E06" modified="2013-12-11" version="1">MTKLEKNVHAQPQTARLRAGRLRMLIMMRIRICIVQDSRIGGYAQERSVVRGHLIASSTSHLADPDLTGGGDGGERHAELWLLSGKGDEDQRGCAMNSARRYLEYRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPT4</accession>
    <name>U4LPT4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936498">
        <property type="protein sequence ID" value="CCX16675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPT4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11565" checksum="00FF333C41ED29A5" modified="2013-12-11" version="1">MSSYITNDEIDRRIDVATKTVIQEMTKHGLRALEDRVERLEELCEKLIEEDHKLRERLTLLQLAMGPAKDQMDIETNGAAMENHEEEVTGEEAAIKKENGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ54</accession>
    <name>U4LQ54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ54"/>
    <dbReference type="STRING" id="1076935.U4LQ54"/>
    <dbReference type="eggNOG" id="ENOG502SHBR">
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    </dbReference>
    <dbReference type="OrthoDB" id="5324651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="636" mass="70392" checksum="3B429744FBD0B5EA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQY7</accession>
    <name>U4LQY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peroxisomal biogenesis factor 3 acc. no. Q92262</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQY7"/>
    <dbReference type="STRING" id="1076935.U4LQY7"/>
    <dbReference type="eggNOG" id="KOG4444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRGWKDL"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="510" mass="54939" checksum="7F6B133146CBE891" modified="2013-12-11" version="1">MPAMFTSTRSFIKRHRTNLAVGFGIVGAGYLAVQYIGNKLSEARSQLMSDRQAKENINRRFQTNQSDCTYTVLALLPSVTSNILTRYPVETSLAELHQRKAARIARSSATASTAGGTTSSPAPVDNDDTASLASFSSETFNAAPRKSKPQLWDEIKFYSLIRSFTLLYTLSLLTLLTRVQLNLLGRKNYLSSVLKSAERADDPTIFLEGEGEGGEGVDVETNRQYLSFCWWLLHRGWSSLADKVEAATKQVFSSVNPRDTLSLGHFRSLVMEVRKIVECPPVSATEAEQGNFGGEINWLEFLLPPREQEGMVLRESLGEEAPKEVSKELRRLMDETSDLLESPNAKTVLGHMLAVGFEMLVEAKVAGVAFKGKPSAADALKATVAGNATAAAAAATASPVIGPPPRQVENVRRASMASTSSGMGGMGPLFGGITSGEDSDAGYSPRITEVVPDENTAQFAIVLAALQRQAQAIGVGVGNEFLSAIEKGTELEGFSAQVYSSNFEFVTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR31</accession>
    <name>U4LR31_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR31"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="263" mass="29855" checksum="E9DD0AB0BC83BCCC" modified="2013-12-11" version="1">MDGIQDIAKKNIKYFTEKTPEQPDPLSKDAGCLFLFALVAIGFFGMMFYYCRNKARERAKKKTDKAKTVQEKAAKKAAKSGQCWPSHRQQKETDLEAQNNKVTEEEPRNPPPEIQVPENAYFADSPQVCIIRNSLGTQREKFYEILNAEKVPGYTPTPPPAYSPTRLKRLPTPPPQTLEESMQQCLENQRESCQDKTFEVIGGQIEMRVEDKTGRTEQHKGKHTEQHTKKHAEKNAEKHTEQLTGERKGKCAGEQTAGSIDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR36</accession>
    <name>U4LR36_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Nucleoporin nup45 acc. no. Q09793</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR36"/>
    <dbReference type="STRING" id="1076935.U4LR36"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX29761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="471" mass="47584" checksum="A8FA740D94E45D57" modified="2013-12-11" version="1">MSLFDRITPPGGAPAAGNSLFGSTTPAAAPSTGLFGNPTAATTAPANSFFGGATAAPTTTPTTGMFGGGMFGGGAPAATTAPANSLFGGGTTAPATTTTGMFGSTPATTAETGTGMFGSTPATTASATGGPGMFGSTPATTTAPASTGLFGQPATTTAPASTGLFGQPAATTAPASTGLFGQPAATTAPASTGLFGQPAATTAPASGGLFGSAAPATTGAFGTTQTSTGAAGAVAGAAIDPSKLTPTTRFGDCNQILQQSLEGIEAMIQAEISMSAQLAEKFPTHREALESIPLDASVLSNRLATTKSFQLTDQSAYDQVRSAHEADDHAASLSIRTLDLFRLPHAQRSQYIQRTTNFNVPQRENDVTGNKPMIAYFNKQADEMEKKMEMIRNVVRQVEESLVSVESQAIQGARGAHVNGGDITNVTGGVAGRQDARRLNSALREFNDALKTVSGRIVDAQESLEELWGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRH9</accession>
    <name>U4LRH9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Sec14 cytosolic factor acc. no. Q10137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRH9"/>
    <dbReference type="STRING" id="1076935.U4LRH9"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="95"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="292" mass="33579" checksum="68B0AF2C6BE189DB" modified="2013-12-11" version="1">MSTEYTYPATNPNAEPGHPGNTTPEDDARVVQLREQLHAEGYTDRTDTNTLLRFLRAVKNEADLVGKAKDKFVEVEKWRKEFEVDKLVEEFEYTEKDKVFEYYPQYYHKTDKDGRPLYFERLGKINLKKMKAITDEKRMIQNLVVEYERVADDRLPACSRKAGKLLETCCTVLDLQGVGPKTIWDSMDFLRKINQISSTYYPERLGKLLIINPPTLFNACFNTIKGFLDPVTANKIKICKLPELLDYIPAENLPVDFGGQCTCEDLGGCHRSDAGPWNEEKYTQPSLTDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSB1</accession>
    <name>U4LSB1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSB1"/>
    <dbReference type="STRING" id="1076935.U4LSB1"/>
    <dbReference type="eggNOG" id="ENOG502S8GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EAWRAVP"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="205" mass="23489" checksum="FE940B80710353EF" modified="2013-12-11" version="1">MSISHRISIRWLPSPASEPHSVLVLTSPARRYVDIRLTLSPSGELEGLYWGFAGQSFYPTPNSGRWEHFIDSRSDEPGSDEGSLEVLENGDVLEKGKMVDFEEPDKGEKEYEEVWRDEVLEKDERVAIVMETEGGRVVRVGGWVQGVLKDKEGFNAERWKDGKRIWGMGKELASDEIWEKEKELVVGDEVEKRGLVWRVVERAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSM7</accession>
    <name>U4LSM7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_12982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSM7"/>
    <dbReference type="STRING" id="1076935.U4LSM7"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ELLECEW"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="37"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="545" mass="60941" checksum="BCF79F97B24BDFC2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSS4</accession>
    <name>U4LSS4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PCON_04194</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 100304</strain>
            <tissue evidence="25">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSS4"/>
    <dbReference type="STRING" id="1076935.U4LSS4"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASRFNWG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="844"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
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        </location>
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        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
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        <location>
            <begin position="33"/>
            <end position="107"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119134" checksum="1C13062476BBBC54" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTK7</accession>
    <name>U4LTK7_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="14279" checksum="717CE2E3A05CDE8D" modified="2013-12-11" version="1">MEWLYKEDSFAPDIVTMQFPTFILLIAVFLTCLISFVAAEPRLTICGGTNHSGGCKGISFRRGEPDCKNVGRDWWKRTKSYRVEGGCCTFYSNLQCFDSDRLDLRTTGDNMNVGNKGIISARCVQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTY1</accession>
    <name>U4LTY1_PYROM</name>
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        <submittedName>
            <fullName evidence="12">Similar to Pre-mRNA-splicing factor slt11 acc. no. Q4W9V0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_14250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="356" mass="38969" checksum="F8EFEA14753DE3C7" modified="2013-12-11" version="1">MPPKSDPNRAGRETTDFPSVCEPCLGPNPYIQMLKAPLDLECKICTRPFTVFRWSVDRTIRNKKTNICLTCARLKNCCQCCMLDLSFGLPIAIRDAALKLVAQGPQSDINKQYYAQNHEGELKDGGVPEEYEKTDGAARELLKRLAGSEPYQRRRDGGEGSQTGQKLLAGGTGPVRNARGGEKTRGVKGKGKVGRFTNNQLPAGPADITPPQDQSIMSLFLTGVEDDLAEHQIRTFFSAFGAIKSIVCVHRSHCAFVNFASRAGAEAAAESCQGKAVIAGCPLKIQWGKPRPLGNIDRSQGGNKSTGEVMVEQQEAEEPQQQQHERQERQQSFANIQIAKPPGEDDEVRYPSQAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUH8</accession>
    <name>U4LUH8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUH8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="21" mass="2663" checksum="AE14B37760E0FFC1" modified="2013-12-11" version="1">MWTYFYFIVFVAETNSFLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUX4</accession>
    <name>U4LUX4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Short coiled-coil protein homolog acc. no. A8NJZ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_12230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935722">
        <property type="protein sequence ID" value="CCX32026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUX4"/>
    <dbReference type="STRING" id="1076935.U4LUX4"/>
    <dbReference type="eggNOG" id="ENOG502S4IZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDHHATH"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX32026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="167" mass="18698" checksum="4671DCCABF62E310" modified="2013-12-11" version="1">MVTPTRPPNNRTLSTRSTTEPVELPLNNSSTVSTPSIADDNDPLRDSIEASEKDDMCDNEDDERRGRSSTIDPMKYEMDPRNMSPRRDSEELDQLGAEAKARLEAQAQTLQSGLRALLDRVEKVREEHDRLEGENRFLQEYIGSLVATSNRPASGARGRNSGGRINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUY2</accession>
    <name>U4LUY2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase SUV3, mitochondrial</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_12316</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUY2"/>
    <dbReference type="STRING" id="1076935.U4LUY2"/>
    <dbReference type="eggNOG" id="KOG0953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001549">
        <property type="entry name" value="SUV3p ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="402"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="799"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="852" mass="95446" checksum="1724CF3A932692BB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVM7</accession>
    <name>U4LVM7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Mitochondrial inner membrane protein OXA1 acc. no. O13375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_13532</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVM7"/>
    <dbReference type="STRING" id="1076935.U4LVM7"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWKNAQT"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="139"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="455" mass="50155" checksum="729543E197DD08F3" modified="2013-12-11" version="1">MLVSKVLRRSALPISALRPVAAIPKARALHVASGSKLRPTVTPLNKTRFTPSLTAIRFNSTSSSTPAAAAAATSSAPSEPVTDPNILNDIIDPVAPALTALSPDQMGYLKSLGIDFGWGISSCIQTLLEAVHVYGHLPWWATVLATVLAVRAAQFPLYLKQSDTNAKMKEIGPALTPITNQMKLAQQKGDMQGMLTARSEIQRYLKVSGIQRKWLFLPLTQIPVYYGFFRNFREMSDVPVPALVNDGILWFQDLSVQDPYFILPALSSAFIAMNLKAASQQNNNFAVSVQTALMIALPTFSFVITCQWPALITFYFMLSSMVAYGQTKMFNNPKFRKMFGLYPLPEVAINPLAPTTPNTIDGTINNASEPSTQIGAKGSFLDKLTGGKGGWQDKLTGKLDSNDAAMSVKGLFEKNAAKQKEREHKLYEERRKAKIAEQQKAEELARERRRRMKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVT9</accession>
    <name>U4LVT9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Rho-type GTPase-activating protein 1 acc. no. O43052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_04385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVT9"/>
    <dbReference type="STRING" id="1076935.U4LVT9"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WQMQSSV"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000033">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000112">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="452"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="816"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1163"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1169" mass="130719" checksum="4C0E98E13CA59E08" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVY8</accession>
    <name>U4LVY8_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVY8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6120" checksum="B419F6D43180161B" modified="2013-12-11" version="1">MVEKTSALSSVFRVLHVAATPSGSASRVTNFSPAHPNFGVSPGLAWVWAGGLVGLEAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW42</accession>
    <name>U4LW42_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW42"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4313" checksum="08E8B51CFF0C8AB6" modified="2013-12-11" version="1">MKIPLLKPLTDRLLNSGYQTNSGCLTRFSSGLTVTETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWA9</accession>
    <name>U4LWA9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_01186</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF936097">
        <property type="protein sequence ID" value="CCX33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWA9"/>
    <dbReference type="STRING" id="1076935.U4LWA9"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000342">
        <property type="entry name" value="Serine/threonine-protein kinase VPS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="926"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1280" mass="144320" checksum="0ACE151EBF87AD78" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXW2</accession>
    <name>U4LXW2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_04126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34643.1"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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    <accession>U4LYN3</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <end position="20"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="CCX34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <end position="1121"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX04338.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUC7</accession>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUC7"/>
    <dbReference type="STRING" id="1076935.U4KUC7"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFGWARQ"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX04592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="321" mass="35181" checksum="5883A836598A9912" modified="2013-12-11" version="1">MPSNAIKLLAGNSHPELAKRVSERLGVELLDMSVFKYSNQETSVIMRESVRDEDVFVLQTTSPGEDLNDHLMELLIIVKACKTASARRITAIMPNFPYARQDKKDKSRAPISAKLIANMIQRAGCDHVITMDLHASQIQGFFDVPVDNLYAEPLTLRYIRENFDYKNAVIVSPDAGGAKRATALADRLDLNFALIHKERSRPNEVARMTLVGDVQGKIAILVDDMADTCGTLCKAAEILTNNGAKQVVAIVTHGILSGNACEKVTASKLSRLVVTDTVPHAEKKARCPKIDTIDVAPTLAEACRRTHNGESVSFLFGHAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV90</accession>
    <name>U4KV90_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV90"/>
    <dbReference type="eggNOG" id="ENOG502SBYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPTRELM"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="217" mass="24333" checksum="AE91C1420E7A7DA0" modified="2013-12-11" version="1">MGAIRPGNKTRPAGDKKKGFSVGPANLPDGVYKRKVTKIKNALIQKAKVRKQYSKTLSTTGNLVTDPNAIRAQKLFEEAEQERKARSAAAKAANAEDAAMEGAESIDAPPAINADRQAMIDREDQVESTAKTPFERRQRKPKTSSFMKEESMAARQKREREEAAKAAEQRRQDREQKLEQRDMHKRSMSARTRTGQVKLGKTSHVLLDKIMQQMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVG2</accession>
    <name>U4KVG2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935259">
        <property type="protein sequence ID" value="CCX05548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVG2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="8542" checksum="60ABD0154A31376E" modified="2013-12-11" version="1">MSTFVTRASSAAPSSGDNIVQLPALGNNNPNDPRQFSNAAYMAAANSGVPVTSTLTTATGDMLQYYLNEPQHEGGCVIIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVV6</accession>
    <name>U4KVV6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cell morphogenesis protein PAG1 acc. no. P40468</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KVV6"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRADTMK"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="365"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1502"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1797"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="2013"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2279"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2481"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2285"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2491"/>
            <end position="2505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2505" mass="281231" checksum="DE38ED5F3E25A2BE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW78</accession>
    <name>U4KW78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935247">
        <property type="protein sequence ID" value="CCX05336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW78"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6108" checksum="B1AAF3B447D52126" modified="2013-12-11" version="1">MVMMALVGYAGAGAASQGSAVVRCYGDSTCGYQFNHPYLKYHSRAVGLGHKYSRDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWF3</accession>
    <name>U4KWF3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UPF0047 protein C4A8.02c acc. no. O14155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWF3"/>
    <dbReference type="STRING" id="1076935.U4KWF3"/>
    <dbReference type="eggNOG" id="KOG3267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWQGIFF"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="148" mass="16509" checksum="5BF3C550836CF633" modified="2013-12-11" version="1">MSTPQWFQKSLRLPSKARGSYLITTDIVNALPEIKNYKTGLLTLFIQHTSCALSLNENWDSDVRLDMSDAMDRIVAEDKKGEGIYRHDAEGSDDMPAHIKSALIGASVTVPITNGKLALGTWQGIWYMEFRAQKHTRSIVATINGQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWF6</accession>
    <name>U4KWF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Mitochondrial chaperone BCS1 acc. no. P32839</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_05399</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWF6"/>
    <dbReference type="STRING" id="1076935.U4KWF6"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="55"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="275"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX05812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="482" mass="53196" checksum="A065E399BD014456" modified="2013-12-11" version="1">MPDNSALQKIGLPVPPERDDASLPSKASEASSGPFGNAFSSLRENPLFTGGLAIAAMGAAAQLLRKSSTRALQLARRQMLVTVEIPSSDPSYEWFLHFLANHQRQGAALEAIPGYSLSALLSRFRPAPRELAVETRTMKTPSGAAVADFVLVPGQGRHIINYNSTLLQIERMRDSKRMNPNGTPFETVEVTTLFSRRSVLTEMLRESQAMAMGLAEGKTTVYMSRGIEWQRFGAPQRKRPLSSVILAQGVKERVVNDLHDFMSAADWYRDRGIPYRRGYLLYGPPGTGKTSFVKAIAGELDYNICLINLSERGLTDDRLNHLLSNMPERSIALLEDVDAAFANRTQTAEDGYRGANVTFSGLLNAIDGAASGEDRIIMLTTNHADRLDEALLRPGRVDMKVEIGYATKEVVDGMWERFYGPDNFPESTEGLKKRFLEILEKGQLFNEDRGVSTAELQGMFLFFKSDPQGVVQQAENLVGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWG7</accession>
    <name>U4KWG7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Uncharacterized membrane protein YGL140C acc. no. P53120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_05058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWG7"/>
    <dbReference type="STRING" id="1076935.U4KWG7"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VTWPAFV"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF4">
        <property type="entry name" value="AFR661WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="126"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="594"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="776"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX05471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117255" checksum="D1F7D55E0612E18C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWM5</accession>
    <name>U4KWM5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWM5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5058" checksum="DE292CB9E8E336AD" modified="2013-12-11" version="1">MVCVYGSSTSQRDVDRFQLGFVACVQGSCTQRADAIILHFCLDDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWW1</accession>
    <name>U4KWW1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Dihydroxyacetone kinase 2 acc. no. O74215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_05323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935269">
        <property type="protein sequence ID" value="CCX05736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWW1"/>
    <dbReference type="STRING" id="1076935.U4KWW1"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGLCLKT"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="11"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="389"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX05736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="597" mass="62790" checksum="683FFD1641978FCE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX88</accession>
    <name>U4KX88_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Uncharacterized protein C4.03c acc. no. Q9USS7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_06239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX88"/>
    <dbReference type="STRING" id="1076935.U4KX88"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="416"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="671"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="768"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="896"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX06652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113934" checksum="C63F24F19A7C04EC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXB9</accession>
    <name>U4KXB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935310">
        <property type="protein sequence ID" value="CCX06762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXB9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651491" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6914" checksum="240DC50D4B1181FC" modified="2013-12-11" version="1">MNLTPAFWPPCRCLALLIEIITFLESQGPVFRVCIFKMPRIVALGDEDTEFPLQKFAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY94</accession>
    <name>U4KY94_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935339">
        <property type="protein sequence ID" value="CCX07182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY94"/>
    <dbReference type="STRING" id="1076935.U4KY94"/>
    <dbReference type="OrthoDB" id="3562449at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="375" mass="42972" checksum="E2C4579179F5B4B3" modified="2013-12-11" version="1">MLMGVDKSPKTEDYWRKPDGCSTVHPFDEHISLGRFQQIKRYLHISRPEASDLDSAFDESEDITILIKKVHWLFEHFRKCCKSFRASGSRGTVDGSMTVHTGKTQPKHFIGKPICKGYYRMFVTTEGGYVYDCYPKTPSSKQHNNTVGEVSTEGKDKQNVEISKVRAEYPMDKPTSRSWMLLFSYVGDTVMGNSYIIYKDELLKIEPDTRERNILPYRDFIRQVAWDHILAGAKFGPSKSTNNTTSTPRSTTILKNTSISPLSERFSEHVIIKGPKRSCWLCNLREKTSGLRAKRKELQTLAKSTSSSAKVMSMARTVNRCRKCNKNLCFSSEKNCWTDYHTKSWAELGIDKAMEEELKKEDHGDDQDSVDECYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYR4</accession>
    <name>U4KYR4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935315">
        <property type="protein sequence ID" value="CCX06805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYR4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="11112" checksum="62C8CAA7363A5541" modified="2013-12-11" version="1">MRTHPILRRLFLVRRKLLGKNYTRPTSSASTAYHNKTPRQGFETILRFEKLRLWENVLWGKATTNYIAPEMMVQLGAASVAAWALYEMNRMEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYW1</accession>
    <name>U4KYW1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYW1"/>
    <dbReference type="OrthoDB" id="5409221at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651743" evidence="1">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="84" mass="9069" checksum="0CBEDE96CD6A383B" modified="2013-12-11" version="1">MQFSTISFAIAAVMASVVTAAPVAEPKNVFRPENIGMGYCGRKVSGPRTYEPFPGKFGKILGPEDALRETEVDQNNMQTDCITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZT2</accession>
    <name>U4KZT2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935347">
        <property type="protein sequence ID" value="CCX07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZT2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2804" checksum="8828690DD8FE9B0A" modified="2013-12-11" version="1">MFFSAHRLTCIVQLRTARGRHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZX1</accession>
    <name>U4KZX1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZX1"/>
    <dbReference type="STRING" id="1076935.U4KZX1"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NYPMAKG"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025085280" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX07774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="377" mass="39300" checksum="07B418F14CDBC725" modified="2013-12-11" version="1">MHSSHRLLLLSLLPLALSSCIDNTRLKPRAATGAVPISTFGYTGLLGPLNWAGLSPANSACSTSLTQSPINIDPSIISLLPSAPVLDFPSVAAAEFENLGSTIEVITNGTTTIDGTTFNLKQFHFHAPSEHRINEEFFPLEVHMVHESATGELAVVALMFQLSSTETTELLTKVTENIDKIQTPGTRTETGALDFGAVVEHVQTTPLFTYKGSLTTPPCAEGLTFIIPQAPLPVNVETFNKIKSTVKFNSRYTQNDLGKANILDVGCTAAAGAKIEAGKAVGGNGTAVAPAPVTQPAAGKQPSHSVAPPVVAPPAASAAPVEAPASALPVPKASSAVKEEAATGAGAQPVHHCIMGACHTVPAAPARRARRWFQLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L020</accession>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16811" checksum="5220D8E625AD693E" modified="2013-12-11" version="1">METYPAYLYPIRMLQGLLSIGLILCTTYAVAHPAYWLYLFEPAACTIITSIFTLLSLIFLPWQQYRRQISPTWFKATALDGISFMLFIVSLVMLVRPVKEMDAMTRHRFYDPYHDGAWELPAPPREVWRVARVLAGMQVRSIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L035</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <source>
            <strain evidence="2">CBS 100304</strain>
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            <dbReference type="EMBL" id="CCX07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4874" checksum="936C88484C73FF79" modified="2013-12-11" version="1">MRRGKVIRSTSHKGEWSSERNEWTHLYAQVKRRRHKHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0J6</accession>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX08745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="4037" checksum="7BF92BD8F1133525" modified="2013-12-11" version="1">MRAMLLRLDSAKLARLKEINEGHHQSFFESLRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0L9</accession>
    <name>U4L0L9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935369">
        <property type="protein sequence ID" value="CCX07743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651565" evidence="2">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="182" mass="20182" checksum="45D664D8E60AF15E" modified="2013-12-11" version="1">MQQSYSTNQSLPAVLLLLLLGLFTTSAAALDSISKVECDTLIAFGCIAFAVVVFAGGFHYFRRHRKQSAARCEEEERERERRAEEVAMMAKQMCSRCGKVLSGDWCIPRKKVAKLRTVIPKELGGQEYKESCAGPLTLDLGDLGLAKEGSPMMMNWSDIWKRGKADDQDMEKGLLVRGSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0V8</accession>
    <name>U4L0V8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09262.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0V8"/>
    <dbReference type="OrthoDB" id="3789824at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="143" mass="16594" checksum="D61606D10248D280" modified="2013-12-11" version="1">MRWPRRHVRSVIQPPTPANTIYPEYANLTEIMTKQSENWNCDEWSFGQILTLSLWAPAILELLYILLFQKNEFTGTLLLKLRFTWRKVEENSDCKYTDLPSDDEQAKTPNITQAEVSSTDVSDSELEPYSLARLDLVGRFVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L100</accession>
    <name>U4L100_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Nibrin family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX07933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L100"/>
    <dbReference type="STRING" id="1076935.U4L100"/>
    <dbReference type="eggNOG" id="ENOG502RCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GIGDHYW"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="839"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="982" mass="107594" checksum="9EADCBFE8CFD047C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1B1</accession>
    <name>U4L1B1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_09245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935478">
        <property type="protein sequence ID" value="CCX09652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1B1"/>
    <dbReference type="STRING" id="1076935.U4L1B1"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTTHFWG"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX09652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="13834" checksum="C60F038518C92A2E" modified="2013-12-11" version="1">MAAVFKALNAKIRSNKYTDYFCSTHFWGPASNFGIPVAAVLDISRKEPDVISGKMTAALVVYSAVFMRYSLAVQPANYLLFGCHFVNECAQLAQGYRYVQYWHNGGREAKLAEQALNSGVEAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L232</accession>
    <name>U4L232_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L232"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX08921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="175" mass="18555" checksum="A3B09B3AA82872DC" modified="2013-12-11" version="1">MEGWTTYFRPGVSAGSLLQVGCHKQEFMISQAEWPREDVLGVIRAVYPLKKDLAANTIGASNGAGTAIGVIAGIAGMVLLGFAVVRVKTGHWWPFGEANKAQELPVEGMSSGKSVGSIGPLVGVDQDYVVQLQEMYTHQDAVELPAEELGYQPSMLKSSRVPSPSLSGPAAIQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L323</accession>
    <name>U4L323_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L323"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3858" checksum="A933B7DAE419194F" modified="2013-12-11" version="1">MSTLRLDRGPPSTPSSEVLRYYVKNITADLYGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3R4</accession>
    <name>U4L3R4_PYROM</name>
    <protein>
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                <person name="Gabaldon T."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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    </dbReference>
    <dbReference type="OMA" id="TIRTWPL"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF681">
        <property type="entry name" value="F-BOX PROTEIN MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="383" mass="41560" checksum="3DE32B148288776F" modified="2013-12-11" version="1">MSQSVDPGHFFQTDASEATRARRAAKANNTFGEPLQASSKILALLPALHKKNHVFIAESCGVIRLVDLENNNTKAALFRGFSTPCTCLALSSDGTTLFAGAWEKRILAWNISTRQVTAEFKGHADFVKSLLYVPTPTGGLLLSGSSDANIIVWNPITGDRIATLKGHTRAIGTMALDPTATDDEAAVVFAGGSEREIRKWRIPYNNPGAAEEVDVLLECETSVHALRFLGDDGDLWAASADGTARRIDVTDGKKPGERTDTKLVHADYVNDVVICNNGQWVATGCRDEEVRLWDVSNGALVHTFEGHADEVTALAVVGSWLVSAGIDCTVRRWSVKPVDVKEAIEEARKRKEGVVEEKEEAKEEGLLTAEEEAELAELMDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5Z6</accession>
    <name>U4L5Z6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="18">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PCON_05022</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 100304</strain>
            <tissue evidence="25">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="18"/>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5Z6"/>
    <dbReference type="STRING" id="1076935.U4L5Z6"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGKPAEC"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000004">
        <property type="entry name" value="7-dehydrocholesterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 23" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16 23" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CCX05435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="532" mass="59573" checksum="B5AFA8CE685D2633" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L604</accession>
    <name>U4L604_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L604"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651701" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8306" checksum="FC9927D1D28CFA0D" modified="2013-12-11" version="1">MKLTALHLILVATAASGMSRIRVITAECGQHVADYVLLVGWEFWSSRALVVGAVLVATSSFVVNVQSTSSAVPDPGGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L608</accession>
    <name>U4L608_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L608"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7060" checksum="B5985C57E2B8182D" modified="2013-12-11" version="1">MRYVCIYSARQRARNFQHNIPRGTSTQNAQHLTLTTIPGSPGSPMSSHSKNRGCCQLSKSPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6C1</accession>
    <name>U4L6C1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935732">
        <property type="protein sequence ID" value="CCX12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6C1"/>
    <dbReference type="STRING" id="1076935.U4L6C1"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="259"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="473" mass="53892" checksum="E209EE9FA3B62ECD" modified="2013-12-11" version="1">MMAAQMNGGAARMHDDDSDDEGLATTLVEAMQEDDGDYDDVADGTGVQVTGDDLQARLAAAATPLDFAAGLPARFTSYDNYCSLFHFILNSDGPVDLELPTVYWAWDVIDEFIYQFNSFCTYRQKAARTGENPEEIQVLRENPQAWGCYSVLNVLYSLIQRSQMNEQLAAIKANKDPNTVAGEYGQRPLYRMLGYFSIIGLLRVHCLLGDFTLALKTLDDIELNKKAVFAKVMAAHFTTYYYVGFSYMMLRRYADAIRTFSHILVYVSRTKGFQKNSQFDSITKENDRMYALIAICVALCPVRLDDTIHTTLREKYGEEFALMQRGGPEALPVFEKLFLQACPKFISPNPPDFENPENNVDPSEHHLKVFMQDVKNTISAPILKSYLKLYTTMDLNKLAKFVETDPEALRKQLIVYKQKNRQLRWTEGSLLDGEMTHTSDLDFALQDDIVHVSEAKVGRRLVDWYLRNLQRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6D5</accession>
    <name>U4L6D5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Metal resistance protein YCF1 acc. no. P39109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_11629</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L6D5"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFETGMR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
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        <property type="protein sequence ID" value="CCX13212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8P5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="25802" checksum="2E4989BE96249A0E" modified="2013-12-11" version="1">MPKDLVKEKINTFCAAMNNQNVSAKKGESNRKATYGSGVSGGFRRLRRSPPTQFVTTSVTWTKDKGYDKFSWKIREGVCKQGLMDAMDSCDGNNSPGGTSNMQGLMDAMDSCDGNDSPGGTSNIGCTEWKIEITKGAPKQEPPKDPLPPPKPAPASCKIEDQSQGKKRFNILWDKGLNGVDCDKMQQAIGRIKSQGNTCVTTQAYPQAQIVLFEINPADAGKMSEILAGLFLGVKPNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Q3</accession>
    <name>U4L8Q3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Q3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="185" mass="21440" checksum="8D838D8A58AC798A" modified="2013-12-11" version="1">MSRVMSLGSFAMSNTSKFYSPFTYQYDTMRIFEDKPMDVFGIVVPCYPPKEEITEGHGTYVRDKENNCLTDFSTTPLEDKVLSTMLTKLDKLQRFQQHDGLNEYLRLRLCVSTLYARIDVKTAPSYHQEILLLATDFLQSIVEENDIIHIRGQSGTGKIPFCPTISQSVQRNEHRQRILSFRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Y1</accession>
    <name>U4L8Y1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935501">
        <property type="protein sequence ID" value="CCX09981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Y1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="19" mass="2341" checksum="AEBF3AC019A9D21A" modified="2013-12-11" version="1">MDLRIGRIGRWIWRWIGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9F1</accession>
    <name>U4L9F1_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935519">
        <property type="protein sequence ID" value="CCX10196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9F1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4412" checksum="431E9EBC8FA9B274" modified="2013-12-11" version="1">MNMPNANLSCHPQVFAWSLTQQRSSLSLYNFILRSLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9G2</accession>
    <name>U4L9G2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_09799</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="HF935521">
        <property type="protein sequence ID" value="CCX10206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9G2"/>
    <dbReference type="STRING" id="1076935.U4L9G2"/>
    <dbReference type="eggNOG" id="KOG0089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKVITAE"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="15">
        <location>
            <begin position="32"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="16">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX10206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="328" mass="36270" checksum="E11A6D1E05E7F461" modified="2013-12-11" version="1">MSDKNPSFTPPPTERPSTPPPASCKVVLAGGIAKNLMGEVQTGLQKLGRKPLLVGFLANTDPAAKMYADWTGKTCSENGFEFELRTIDKDNLEDAILNANTDDSVDGIIIYFPVFNNRQDSYLQQLTAPEKDVEGLSHKYLFNMYQNIRFLDAAKTQKSLLPCTPLAIVKILEHVGVYNSVLPYGNRLFGRTVTIVNRSEIVGRPLAALLANDGADVWSVDITGIQRFTRGEGIRRRMHNVQDSDKKLEDVVPMSDVVITGVPSPNYKFPTELLKDGAVCINFSSEKNFGPEVKERASIYVPAIGKVTITILMRNILRLIENRKAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA34</accession>
    <name>U4LA34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936252">
        <property type="protein sequence ID" value="CCX15732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA34"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6747" checksum="E1A8D6254CD7488F" modified="2013-12-11" version="1">MFVSWSDTCAGQMEDPNFELGKPNGDHQYNHSLKSPVFGRLYLPYLQFRISVILIWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAG2</accession>
    <name>U4LAG2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAG2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="33" mass="3481" checksum="0C5F4424D8E5BB8A" modified="2013-12-11" version="1">MSCTSLTDSAVGGLEFSEVVEKGLKISHSELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAH1</accession>
    <name>U4LAH1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_10437</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935568">
        <property type="protein sequence ID" value="CCX10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAH1"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9428" checksum="F3E1E771EB7EE276" modified="2013-12-11" version="1">MPVTINAVYASPNDTNTFVIPTEAAATTEDSTQTDQTNHVKAVREAVAKLQDQVNKYLTEHMEVEKNDAAKTLEDNYGEEVVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAM6</accession>
    <name>U4LAM6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Calcium-binding mitochondrial carrier protein Aralar1 acc. no. Q9VA73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAM6"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX15399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="127" mass="14474" checksum="CABCDD28CD536E4B" modified="2013-12-11" version="1">MVYPIDLVKSRMQNQRSNLVGAARKIPYANVRTFQNVVREMDTVDTVVRCAIAKSKDGKITRADIDCFRKVIKNEGFKGLYSGLAPRLIPEKAIKLTVNDFVRTKLTDKNDKIILPFEMLIEDSVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBJ6</accession>
    <name>U4LBJ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBJ6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="10499" checksum="F1EACB669F402D6A" modified="2013-12-11" version="1">MICKPVGNGKDKAKRSLCFPRNVEPFQPLAAREAAPEPDANPEAAPQVDGGKPKPLPKCIPRFGICHRGDAAKCCDGGICKPSRGTQRLFCFPKGLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBQ5</accession>
    <name>U4LBQ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Probable transporter MCH4 acc. no. Q08268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBQ5"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EWAAFTE"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX11695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="464" mass="50076" checksum="B14B0849F46ED42E" modified="2013-12-11" version="1">MATTETRPVADIADIQEKDDAKSTLTAASKHEGGLSVDPEEERDMGLQLTCSFRSGVGPRELALEHPPDGGLRAWLQVAGTHMTIFSTWGFINSFGIFQAYYVEALQLPPSTISWIGSIQIFLLFLLGSVTGRALDGGFFFSVYRTGSFFVILGIFLTSLGTKYWHIFLSQGLLCGIGSGMIFCPSIALCSTYFQKRRSLAIGIGASGSATGGIIIPLIVQLLLPRVGFPWTMRVLGFVCLFLLTISNIVMKPRLKPRKVGSLIELAAFKEATYTLFALGMFLNFMGLYFAFFYVSAYAKQKIGLSQSDAFTTLIVMNAVGLPGRVVPNYLADRVTGPLNLLIPCAIMVGVLFLCWIAVFSHATLIIWAAFYGIFAAGIQSLFPATLSSLTTDLTKSGTRLGMVFSIVSFACLTGTPIGGAIIQSQMGEYWGGQIFAGCCVLTGGSVLAVSRIKKTGMVWKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBZ3</accession>
    <name>U4LBZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936524">
        <property type="protein sequence ID" value="CCX16804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBZ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5688" checksum="D1E2371585E36840" modified="2013-12-11" version="1">MIPGKITKPHEKESWFAWKISRTRRKMAVLWIPVWSPVIVLAKRYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCW3</accession>
    <name>U4LCW3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCW3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="5964" checksum="E4FB152A3C18ABCC" modified="2013-12-11" version="1">MEVSVCDDLWQYIGEKTEGVRIINFRLFACITPHPVQSALCSPLSSRPPPHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDF9</accession>
    <name>U4LDF9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Monoacylglycerol lipase ABHD12 acc. no. Q08C93</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDF9"/>
    <dbReference type="STRING" id="1076935.U4LDF9"/>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WFKDLNV"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="393" mass="43349" checksum="C288D1E47AC2ADEC" modified="2013-12-11" version="1">MPLLQSIVAKAYYPLLAVGIFYFTCLGLLTHPVIQNNAIYMQKLKLTWRQDLTRPEQFGFAKNQVTPFYLNTTDGESIFAWHVLPLGLYMEHRDELAELETGIETNPAEHRSLQLLKDDPEARLIIHFHGNAGTLGAGIRPIYLRSLSSAHPSKIHILAIDYRGFGLSSGVPSEAGLIEDGLTAFRFASSLGIPSSRIALVGQSLGTAVTIGVADSLASQTPKQELAAVITIAGFSNMKELLQTYHIGGFIPILSPLRGYPKVRGFFESFIYESWNTTARIGSLVKNSPSLSLVLIHAKNDFEIPWQHCEKLFAYATNAAVLQGGEHAEPLTLGEALEIRKVKNYGYESTHAWWPEERSYGRTISQWLVKWGGHNQVVMSAGTSVIVSKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFE6</accession>
    <name>U4LFE6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Glycerophosphodiester phosphodiesterase GDE1 acc. no. Q02979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935458">
        <property type="protein sequence ID" value="CCX30608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFE6"/>
    <dbReference type="STRING" id="1076935.U4LFE6"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WTPMEHA"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="853"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="933"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132685" checksum="0A5C080092784F49" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFM5</accession>
    <name>U4LFM5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFM5"/>
    <dbReference type="OrthoDB" id="10398303at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="273" mass="30450" checksum="467B9F51027D3FAC" modified="2013-12-11" version="1">MATAIVGYANENVAPSVQASMTEKLAQGARIEDINGNKVTTGPLPVPAAQTVINDDKDTTGTVPVPAAQPVQPPYRLERFTILLQDEPEEFDWDNYVPPPISPIVEDLNKDDPEHNSGATSGHTSPNSIDTSEEGSPNARVAWLAPAPPPRRSSRGACTACPIGPQTAEQMVMQEVAAKVIAKDKHEREKLRESMKKIPRAEPGRQSLEIREWFSAKWRRISDAIREKERVKKEKEKKNAGRLLSTNDEISDRRQLLKMETEMGRWFGYEMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFZ3</accession>
    <name>U4LFZ3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFZ3"/>
    <dbReference type="STRING" id="1076935.U4LFZ3"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFQANYG"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="108"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="28455" checksum="94D6A119B08CEC27" modified="2013-12-11" version="1">MAQFFSPPPQQQQGGYGAQNGLQFYQSQYGQVSGHTTPSQGGYGGFGGMGQMGTTPMVSSASGVAGDRGGLRMGWLAAFGTGGYDDEPPLLEELGVNFTHIKGKTLAVLNPLQTVDQHMMDDSDVAGPIIFCVLFGTFLLLSGKVHFGYIYGVALLGSISLHLLFNLMSPPTHSLNYIRSASVLGYCLLPLVFSSGLGVAYPLDGLVGYFLSVAAIVWSTYAASNMFVGVLGVREMRWLVAYPLALFYSVFGIMSIFGSKASGGVAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG35</accession>
    <name>U4LG35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Ubiquitin conjugation factor E4 acc. no. Q9HE05</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_09907</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG35"/>
    <dbReference type="STRING" id="1076935.U4LG35"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLTEIAM"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1101" mass="124065" checksum="55FA4E7F13DF8570" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGC8</accession>
    <name>U4LGC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Subtilisin-like protease 3 acc. no. B6VA86</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936128">
        <property type="protein sequence ID" value="CCX15039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGC8"/>
    <dbReference type="STRING" id="1076935.U4LGC8"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TITMSAK"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651351" evidence="8">
        <location>
            <begin position="18"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="207"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX15039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="470" mass="50266" checksum="4361EE5483C0A237" modified="2013-12-11" version="1">MKFSIITILSLASFVLAGVPARKQSKTPEYIPDSYIIQFKDTITMSAKGDNAHFKWLNEALAKENVKREAGAPKYGVKSKYQIPGFMGYSGTFSKSIVDEIKARNEVVDVTQDAIVRTQAPSGLMDGLGKSALVTPVRPTAPDSLLSQRFPCTEQQLSTVEDDGMWGLGRISHIGTPPNTTESGWPKYVYDRYTGKCPRDSPPTAYVIDSGILSNHPDYAGRAENGFNYKPGVWPNEDVCGHGTHVAGIIGGTKHGVMKSTRLIGVKVLEGADAECSGTWSGVIAGVNWAIKDAKLKNALKTSVINMSLGGASYPPVNKAVQAAIDNGMTVVTAAGNAYGADSCEFSPAAVAEAITVGSMSINEQVSPFSNGGCCIDIFAPGQNIQSAYLGNVTRLLSGTSMAAPMVAGLVLYNKCRWGYNSPDSDRRGLLEKYYSDNGALKYFPTGSFDLCAASADMYNRVAFNRANCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGH4</accession>
    <name>U4LGH4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGH4"/>
    <dbReference type="STRING" id="1076935.U4LGH4"/>
    <dbReference type="eggNOG" id="ENOG502S09C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GANILIW"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX15248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="387" mass="43227" checksum="A8FAB0AD46CF709C" modified="2013-12-11" version="1">MSDELGLGPTLLGVMFSLTTLSTIIVILRFYCRAKIIGSVTIDDYLIGFALVQTWGLCVSNYFHVYYGTGKHAQYLTNYMEIIIPTLKLWYAYQLQYLMILYTVKVSILCFYYRLSPQKLYRWSVWGLGGLITAYTVAMFFVNMFECPEDITRAWAITFPQGCNNLVTVYYAMAAFNIFTDILIFILPLPTVMSLQVNKRKRGALLLIFSVGSLAIIASIVRINALYKYMEAAMTGGDIPYVAAYILIWSQVEVNMAISSASGPSLKPLVKSVLGGTSFNKSSYYLRGGSSRSKPQSTPNGHRIYGNDRSAMGRSTDEERDVPLGNYKGHVRSTAIHSSSANTSQENIINSSMGGIMRTTDVKVDVELGIRSKNDSEDSLRRLEYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGT0</accession>
    <name>U4LGT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Nucleolar complex protein 2 acc. no. P39744</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGT0"/>
    <dbReference type="STRING" id="1076935.U4LGT0"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="742" mass="84636" checksum="2609BD802E01C404" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV1</accession>
    <name>U4LGV1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935586">
        <property type="protein sequence ID" value="CCX11024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGV1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="286" mass="35253" checksum="CFA866B140D8D1F1" modified="2013-12-11" version="1">MANLKIYNRYGAEDKEKYGEYCEKLQCKEYEEYADYEERFCEEYCKLGCEEWGECEGHEENEENEENEENKENKENKENKENKEIGEYEEYKEYENVEDNEDHDDNDEMNKYREYKENEEMNEYEECKEYEEIDENENNVEYEENEEHEYYEENDESEECEEYEEIEEIEKNEHYEEVDSKEEENRENEEEEEEEEEEEEEEEGDEEDSLAENDMKSINMLFDQPSDDLVEAHSEFNIEQYYLDYYKDLPDYKTEEELHRAIFMHELSTHMNTDDLNAEPKLPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV3</accession>
    <name>U4LGV3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936188">
        <property type="protein sequence ID" value="CCX15516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGV3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="8863" checksum="72E0D0B62BC26BD6" modified="2013-12-11" version="1">MASLTAFSVTLLSHCPFISTHLNLTTHVAHLSTDLLINLNQLCKDIAAMTGSMTQRYAAYTRLRQHQMDLEKLDCEGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH01</accession>
    <name>U4LH01_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH01"/>
    <dbReference type="STRING" id="1076935.U4LH01"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDIGDAY"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02666">
        <property type="entry name" value="Peptidase_C19J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="657"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="812"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX15593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1251" mass="141605" checksum="8700F353F7484C30" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH79</accession>
    <name>U4LH79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative DNA repair and recombination protein RAD26-like acc. no. Q9JIM3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH79"/>
    <dbReference type="STRING" id="1076935.U4LH79"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMITTYD"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="168"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="544"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="905"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="911"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="957" mass="109125" checksum="5994E0D62692B45D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHD8</accession>
    <name>U4LHD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHD8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="3919" checksum="ADDA4A62862B21A2" modified="2013-12-11" version="1">MRTTDVSCTYELVGAVRDVRASKLIGRTGTPLLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHH7</accession>
    <name>U4LHH7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHH7"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="146" mass="16199" checksum="C3FD689F1A611FDF" modified="2013-12-11" version="1">MVPFSLSASVAGLIGLAIETSKILGGFVADVKNAPDDARTLHMEITAFCQVLEKLVTFLRNEDLKGISFDETSALCSIISSCEEQIQGLYKKLGQRSATTSRIGGIIERIKWPFQKEDFEATVPSITRFTQVFQFSLTIDNWLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHI9</accession>
    <name>U4LHI9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHI9"/>
    <dbReference type="STRING" id="1076935.U4LHI9"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="63"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX15954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="407" mass="44831" checksum="FEFD44AE55DBBA3E" modified="2013-12-11" version="1">MSENLSQYFILVNELAAHNHIDLDGVIPPDVSDADYVHPNDGYILLIANLVLAVISFLVVATRFYTRIFVAGNIGGDDMTIGVALIAVVGSTGLNSWAVYHAGVGKHFYDLAGPIEAERLLKFTYALPIIYSFGVVIIKSSILLYYRRLFGNNKVMQNIVTYFLVFQWVFAIASMLAFATICNPIKAWWVLSLRNAGCPTLRQTMAVYVSLRVITVLCDIGVLCLPMGMVWKLELPLRHRIGLLGVFALGFLACSVAIARLTLLPRLTLTLDVPWNILPIAILDQSEQCLGIITASIPALTALISKFFLRKKLSPTRPYPSSKAIWNGSGSSAEFDFLSFAYDPDRQNLGTYEARAYSTAAPLERGGGSRKGRRGMGKGREKEEDEELVLGDMRGIEKTTTVTVHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI21</accession>
    <name>U4LI21_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Developmental regulator flbA acc. no. P38093</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI21"/>
    <dbReference type="STRING" id="1076935.U4LI21"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="670"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="811"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX16308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="982" mass="105384" checksum="CDD1A2A86102A175" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI94</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_11453</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31809.1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7520" checksum="9954A2250FAEF34E" modified="2013-12-11" version="1">MIHREPLRIDRFGCRLQRFRTSQLFPERFPVNWLPYAIPVDSQSIPIVALRFATVYVQRGCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIM8</accession>
    <name>U4LIM8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIM8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="20270" checksum="299F6FE088A88049" modified="2013-12-11" version="1">MVTSNPPVIQPTDVYSTALPQNLRTTDPLISALANYMTGVQTMFDNFAAMKENMVRTGHPDPKALSDGGPAPTKYVAMAINYRQHHELPVSPQELKDAVLIEGMNAFLDKTVEASRFMATIKTVGQQVELNQKYNQMFMENIEKLEKAVLSEEARGVWIRLFGKLGIPAKVAPMCVTLNGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIX4</accession>
    <name>U4LIX4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10542814at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="222" mass="25711" checksum="EEFADB59EDBEF429" modified="2013-12-11" version="1">MPLTDPNPDDMESVTSPRLKIQTMVKDNKIQFRKILDDFTHHLSREEVGVCDVISHRLSLLELDWTIVQGKLEKEVARMPAETRGARLISDNIVKKDDENEDGTQGGERKDVKDKEGEKLLSPTRRLKRAFSDLFSPSKENLAESSPKEGRGLKHRISKHFVRRSSSPKPDSKGKEVEVKEVKKERLWIDEIYDDIVEGLRRVQEQKETVERLKKERETRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ28</accession>
    <name>U4LJ28_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ28"/>
    <dbReference type="STRING" id="1076935.U4LJ28"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="170" mass="19100" checksum="76EF6EC252890052" modified="2013-12-11" version="1">MSQNIGRTSLAYARSWHLIDMASDQRSLGRIATQIAITLMGKHKPIFNPSTDCGDYVVAVGCHDLHTTGKKKEKKKYYSHSTRPGRLQEITMERMMAKYGGGEVLKKAVSGMLPKNRLREIRLARLRVFEGPGHPYKENIVKINDATVRESTTPVMDAVKELERSKEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ76</accession>
    <name>U4LJ76_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to F-box protein YLR352W acc. no. Q06479</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ76"/>
    <dbReference type="STRING" id="1076935.U4LJ76"/>
    <dbReference type="eggNOG" id="ENOG502R9EV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TKQMNAE"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="569" mass="64234" checksum="6EC1E7669F5BAD22" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJD6</accession>
    <name>U4LJD6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_12333</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJD6"/>
    <dbReference type="STRING" id="1076935.U4LJD6"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GERDWIY"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="14">
        <location>
            <begin position="59"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="12">
        <location>
            <begin position="229"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="13">
        <location>
            <begin position="743"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="904" mass="101814" checksum="8F3C2A5D4EC96BF0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJP2</accession>
    <name>U4LJP2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein kinase domain-containing protein ppk32 acc. no. Q9P7X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJP2"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAHKCIP"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1032" mass="110051" checksum="D7B13FA06C27209C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKG3</accession>
    <name>U4LKG3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKG3"/>
    <dbReference type="STRING" id="1076935.U4LKG3"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="123" mass="13930" checksum="2295371CC124A529" modified="2013-12-11" version="1">MATLYQHGDSHSGGKIISNAWFISEDGKLAPCEFYFSPLGKDQAADFGVSGMKEFLREFMERVKEKGLDKTVALRLFSHKGYTEAFEITEGRANFNLLPGQFPEGDMEKDTTETMWFSVRSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKX1</accession>
    <name>U4LKX1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935409">
        <property type="protein sequence ID" value="CCX30010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKX1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="7724" checksum="42545AFEF21E11D8" modified="2013-12-11" version="1">MSESHRPVLRSISHIVSLWLTGYLRVKPNHFITRKPVVFDGNLGSTRCGHGLAAIVRTLNQTKLNASGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKY1</accession>
    <name>U4LKY1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKY1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="113" mass="13194" checksum="2122364C1B740EAD" modified="2013-12-11" version="1">MEPRPSNLEIRPPPSNKSVSTGDKRKQDYLTDDEQKDLQFKYNLKRVKPEGFWQDKDEDTFNKLWREPKALPVSHGLPDLNEVGRKALCAHWFIEGTYHRDKERGGDKTGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL62</accession>
    <name>U4LL62_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935806">
        <property type="protein sequence ID" value="CCX32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL62"/>
    <dbReference type="STRING" id="1076935.U4LL62"/>
    <dbReference type="eggNOG" id="ENOG502STSV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MERDNNE"/>
    <dbReference type="OrthoDB" id="3563387at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="283" mass="32177" checksum="F3963494CFC651BD" modified="2013-12-11" version="1">MYSLASDTKLSREFFYKNHDKGTGNSPPSSKELRKLTDLWGKVVQDYTNRQVSVGSDKLNAISGIADDFQRYLGGSRYLAGLWEHSLPRDLLWKRSQGTPLPRPIPKEPSINAPSWSWASINGRVDPGLYFKRSAVFNCEIIDCQVQPKDQNAPFGETASGSLKLRARAKEVLWCPDDTFIHQRKSNGEFVRIAKGYLDPVDNLIAMKEENSFLALPLVLKTVDSPYEPVRRSGGPERNLLGLLVVKDKIGEWYRRVGYFDCRFEDTSEEVFAVGEQWELIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL67</accession>
    <name>U4LL67_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL67"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9482" checksum="756359827E5EE0EC" modified="2013-12-11" version="1">MSVICAARLQHARPRHAPFHAATPIISSAPVSDPSKLWAATPGHRHPSTRGRRKAPFLADVSPGHHPLASDCLVFTLAETWQSKLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLC7</accession>
    <name>U4LLC7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLC7"/>
    <dbReference type="OMA" id="RNDEWEM"/>
    <dbReference type="OrthoDB" id="10526822at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652137" evidence="3">
        <location>
            <begin position="26"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="345" mass="36137" checksum="FCC58464D2DB8E6B" modified="2013-12-11" version="1">MQFRTSKTRWYAAILLLLLATIAAAAPKPQESTPQPATPDPTPTPIPVSDPPVTPLTPTPTPDTPKPEEPTTPTPTPESPKPQDPPPTSTPVPEPPKPNPPSVTEVIVTQTGADKIQTVIITSTAQNPAFTPPAAIPTAVPTAPGSPTTTPKSTLNPTDLVPTNTAPKEEPKPIPKVVVVAASLGGAGVLAAIFMGLYFLCCRKKRKNKKNMAVGDDFFAPMAAPGVHQGGAVGYAGHQRNDEWEMQQQRDKSGYRGVGAPAPPPVSPGYKNRSPSPDYGGYRSQVDDPPMDYDRGYGSHSPSPPPQGNGYGELSASPPRTLGIAELPQGSPHRPGVARNTAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLT0</accession>
    <name>U4LLT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Zinc-regulated transporter 2 acc. no. Q12436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCX32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLT0"/>
    <dbReference type="STRING" id="1076935.U4LLT0"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="495" mass="52797" checksum="58F0340505D05CAA" modified="2013-12-11" version="1">MNCPTRDPEPTGNPNFNQSPPLLERSLVPRSSTVCGGGHLSEDEYNLGLHVMALFVVLAQSTFACAFPIIAKRFPRLRIPPSFLFFARHFGTGVLIATAFVHLLPTAFISLTDPCLPAVWNEKYPAMAGAIAMAATFAVIVVEMLFTKGICSGHYNQDDVNNVQLESGRIKHGKRISGSSTSSVQDVGEWVVGGGDVTGRGGRGNGNEAARTEAARGNGGASGNGGNGNTGSAVEEDEGIGGHGGVGRLGFGMAGRRRSRGHSIGLELQRFSTEMASPSPRRSNILEVLSDSEKEAEAEAMGMETSSPSPNKIAFNRRTNSLPPIELTEEQQHKRAMMQCFLLEMGILFHSLFIGMAISVTTGPAFLVLLIAICFHQTFEGLALGSRIAALKWSEGNLRPWFMALAYGMTTPMGQALGLATHTLYSPDSQTGLLVVGIMNAISSGLLLFAGLVELLAEDFLSDESWRVLVGSRRVWACIFVFAGAFGMALVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM65</accession>
    <name>U4LM65_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Microsomal glutathione S-transferase 3 acc. no. Q3T100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936105">
        <property type="protein sequence ID" value="CCX14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM65"/>
    <dbReference type="STRING" id="1076935.U4LM65"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIFNCIQ"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="150" mass="16474" checksum="4570AA153FABD60E" modified="2013-12-11" version="1">MSTIISIPAEYGYVLASIMASTFVNQYHGTLVGIERKSANVPYPNAYATHAEATSDIKKYRFNCAQRAHQNFLEHFPTFIAASAIAGLKYPVATAVMGAVWNVGRIVFARGYINSTQEQKGAGRYKGAWYLLAELGLLGTACYTAYQMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMC4</accession>
    <name>U4LMC4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMC4"/>
    <dbReference type="STRING" id="1076935.U4LMC4"/>
    <dbReference type="eggNOG" id="ENOG502SATJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMASVEM"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="187" mass="19947" checksum="3F378F697E3F35B7" modified="2013-12-11" version="1">MRSSPLSSPPLSSPTARPPTPPRAESLWASMQHTLSEVELSNTAIFFGPSHAKALEDLRAAQIALAQAWMIDSDEPEVGRAGGLHGTQGSQAGGSQAHGAQGSQGSQAHTTTGQIQGQDLKVQGTHGEAEDKRKASEMHFNRVAQGVVEVAERLEKVAQAMRGVERESRGVWEEETIESESVRGSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN90</accession>
    <name>U4LN90_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN90"/>
    <dbReference type="OrthoDB" id="10529712at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="667" mass="74253" checksum="2CF898F47DEAB082" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPN1</accession>
    <name>U4LPN1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX31275.1"/>
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            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="270" mass="30943" checksum="536629A9346FE290" modified="2013-12-11" version="1">MLQPTTISSSRNLFSQHETAEDQESPPMASPSPPQLSCSELSGPSASNQELLDLEPDNHKQHQHYRTSLQPGHLEEPQNPDDSNSGRAGLPPTVPTVAFSSQLSNDQDDPHQLPPPAPPSRKWYHPDEYYDALIQAQREHMLSLGWDWENDADCKAYKTYRRSVRRLESLPWYHLEKISLYVSFGKESAKVWAQDVSDDVAIQTARTKAWAKDLWNDLVNASWPKNMSDSRKRRKAAEEVRRQEMENPRCWCRDCVPGRPLPQFMLPRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPZ0</accession>
    <name>U4LPZ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10737</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPZ0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="6547" checksum="5BAB01D43C97C65F" modified="2013-12-11" version="1">MPTFTKESPRSSYASVSLSQQSQAQVIACPVPTLPLVHHPGMSGAATIPKCRGFVGSLGYGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQU3</accession>
    <name>U4LQU3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936481">
        <property type="protein sequence ID" value="CCX34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQU3"/>
    <dbReference type="OrthoDB" id="5502962at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1113" mass="125022" checksum="2286D038C290A9B8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRZ1</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08058</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="12" mass="1396" checksum="44FC05940D0865B7" modified="2013-12-11" version="1">MLFLLSGRLSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS66</accession>
    <name>U4LS66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FAS1 domain-containing protein AFUA_8G05360 acc. no. Q4WC84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS66"/>
    <dbReference type="STRING" id="1076935.U4LS66"/>
    <dbReference type="eggNOG" id="ENOG502S3U5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWENPED"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651614" evidence="3">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="214" mass="24025" checksum="81FC67A24778BAE9" modified="2013-12-11" version="1">MKLSLTLPFLITTALASQKALGSPSPHDLLPNPYNPHQAQQQQPLMSLTSSDKPPGSPLLGDIISMDKQIAVFSSLARSVASISELLSNRTINTTVLAPSNRAIQSLPRPPWQEPEDTMLEDAVVDEKYRELEGDDRLRRNERRFVGAHCVRWGDAGEWKEGERRKTVEGVEVWWEERGGERFIMPGGIRVGQRKDAVENGELWIVEGVVNYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSB8</accession>
    <name>U4LSB8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized J domain-containing protein C1071.09c acc. no. Q9UTQ5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUK5"/>
    <dbReference type="STRING" id="1076935.U4LUK5"/>
    <dbReference type="eggNOG" id="ENOG502SQBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGVVHSC"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28109" checksum="4AE9B249FC4082FF" modified="2013-12-11" version="1">MLNSSSKITQEYSQIPSTEETEPPNPPRRSHIPLLSSLFCILLGISIGITLGFALKPSSKHASSLVPLEISRNRKPVAFFPDPRYVGGTDEVHQNWRNLVKAGDAVYLPNPQKLGLDKGIKAPPQVSQPKDSRKLVPNFYVISNLHQLHCLSVIRKRYWHIISGKYSPSDADAEAWQEHIDHCVEYLRLGITCGDLLVVEPDSPEGTPKEFTKGNLGWGAVHQCMDWERLIGWQRKQERVWNGTWQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUL2</accession>
    <name>U4LUL2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Isotrichodermin C-15 hydroxylase acc. no. O13317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_11405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUL2"/>
    <dbReference type="STRING" id="1076935.U4LUL2"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMPLDTW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX31761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="520" mass="58819" checksum="A5F774E6D0A071E4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUV3</accession>
    <name>U4LUV3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUV3"/>
    <dbReference type="STRING" id="1076935.U4LUV3"/>
    <dbReference type="eggNOG" id="ENOG502S3FT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRLPYGD"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="69379" checksum="C40E336B697D2B25" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVW2</accession>
    <name>U4LVW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVW2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8050" checksum="EE669FFEB002197D" modified="2013-12-11" version="1">MVFLWLVRWWLSVMSLVARLGWLVSKAVAVSGVARVCHRVGFLCHLGTDQRVVSQLPVASGRSGPVGGECAISGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWD9</accession>
    <name>U4LWD9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Putative membrane-bound O-acyltransferase C24H6.01c acc. no. Q09758</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWD9"/>
    <dbReference type="STRING" id="1076935.U4LWD9"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWHRSYN"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="569" mass="65056" checksum="FB3F92221C5E547A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU11</accession>
    <name>U4KU11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Uncharacterized ATP-dependent helicase C23E6.02 acc. no. O60177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_03245</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KU11"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="738"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1085"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1304"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX04643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1501" mass="166699" checksum="D24D12E9A9E515DD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUI4</accession>
    <name>U4KUI4_PYROM</name>
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        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_04108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650848" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="222"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="350" mass="36501" checksum="FFF913A9308E7D2B" modified="2013-12-11" version="1">MLFRNLALFALAASVSAVSSANEAGDVEQVGEVAQISDAVDSADSADAGETTIMLTITSTSSNYITATDAATASIDSPDSAMPTPDPESSASDASARPTGDTNIMPKPTGSVDDRLDFPPSPAPSAGFGLPPYANSTKPRKCRPSGTFPLPSDNSTSTLPAPQMPPYPNATLPDSGDTAPYPTATLPKIPGTTKTSKAPEETPDAPSESPAPKDGAGEGTWIGSCDESAAKGGVKMLPDSANCDVYWVCDHNKPRKMNCAPGTQFMVADHRCDFPRDGGCKAKGSSTEDVKPAAEEAKTEEAKPEDADTEADVKPEDATAEADAKPEDDAKTQIAERQLRRLARELQYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10562491at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650852" evidence="2">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="14221" checksum="4548CF088B5E1A3F" modified="2013-12-11" version="1">MHPAIFFTLTLLSYSLLSPAAKIDPFLPPVSAIGNIICTPYSHRSRNPSDYRLCRSNLAAQYSPYQGTQGIPESPVTPDETPESPDKAPDSPESPGSSESPGIPGATPSPPPAPAVTKKQPTTLLRTWLHKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUM0</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
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        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="26473" checksum="9F322EFA91159505" modified="2013-12-11" version="1">MAPVSCPYFARKKDAGEKDGLAAESSIRRAIRFSLAKGSIEADKRTPSLGPPILSTTSFDPPPPRQCSPLHVHPALLHSAHFISIIHHGKKERDQGSAQPVKSVEVQWRGRIKMMWNQIDLFYHELTAQQRNALFQQALNPKLSAQSQKLKSYFMSQHDQNRQHAASEAHKYAARFLETTDAGWILQDTSSKTIGTGELNKSNCGEVRTVGPAIWNNEDVNRLFHRRFTEESKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVU9</accession>
    <name>U4KVU9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVU9"/>
    <dbReference type="STRING" id="1076935.U4KVU9"/>
    <dbReference type="OMA" id="CEEVIYK"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="38399" checksum="5B5296216A436FB5" modified="2013-12-11" version="1">MAPTTRNRSKTTSAPAPVAEPVKTTKAAAQKTVKKAAAPARKAAAKKTEEVAEPEQKKGHVKFDSDNEGDVEEPVAVQADAVKKEEPEAEENSEDEDSDDEAPEAVSASSGKQAAKKKEEEAKKAIEAQEEAARQKRKRREEVLKEQKADARKRRKVVEEPAAETTEAADSDDEDEDNKIAVVPKSKDAKAPALLPTALLERIDGRPSQHTRLDSDDESEADEEEDDFGEMEGLDGIEGGAIPAEILKMMKKEKDNEKRQERKGKQAETKKGPVTVKVIKDDAKMRKILPPPSNKKEQNTKHSWMAGRGQVRRKTSRPRLGDACFCEEVIYKEDLMKCIRGSIVGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXD5</accession>
    <name>U4KXD5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06374</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935313">
        <property type="protein sequence ID" value="CCX06787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXD5"/>
    <dbReference type="OrthoDB" id="10405564at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="203" mass="23205" checksum="DAE45AE75579E0EC" modified="2013-12-11" version="1">MKLRSGSYMPKPRNKRASATATNARELKIRILKRKRKNRVADSLQLIKELAKDLSPDFTSARERAFYSYEMDTYGALPEFRMPWEVRFELADMWDGLLNFTDVEVPAPPVLPNFQHTEGCQGLGKARGICFSHQDLVGSLMEERAWNRYHEDVNEKERAYAVSKAPSVYSKGYGWTGWKDGGFKVRGSVGVYKRRMAKKGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY26</accession>
    <name>U4KY26_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="9" mass="1093" checksum="0158B2D416DEB870" modified="2013-12-11" version="1">MIGCQRVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYL2</accession>
    <name>U4KYL2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYL2"/>
    <dbReference type="STRING" id="1076935.U4KYL2"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="252" mass="27972" checksum="95767A8B05C92299" modified="2013-12-11" version="1">MSAALPADTVAAPRARKAFIPLECNPELMTRLVHDLGLSSRFGFVDVYSISDPDLLAFVPRPALALLLVFPVSESYENARLEEDATLEDWNKKGEEEDPMWFKQTIRNACGMMGVLHAVANGARELIRPDTPLSRLLDRTRPLGRLDRARALEESDELEVAHKHAATQGDSAVPNAEDEVELHYVCFTKSAKNGHLYELDGRRKGPLDRGQLGEEDDVLCDKAAAVVQSFIDREKQSGRLDFSLVALTPTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYT0</accession>
    <name>U4KYT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935316">
        <property type="protein sequence ID" value="CCX06825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYT0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="341" mass="38137" checksum="89892B54572A9870" modified="2013-12-11" version="1">MSYNSQLFTLQLHHKSLEAKSQKQASLIRKLEQKLSETNLALHTEKRKNEHLQRWKEDHAREMAQMAAERIASVAYSKKIETKKIKTSCICYKEEILGAICKIHKATPAPGELQEPREIYTVDLQPILDAIQQAIPPPEPVNVSIEIPQPLLDTLHNEMATCREEAAEILAGINRETSARQKEYQLSLNTLSAENEVLKDELSDARKEIKEIKGCIEGILKEFKEVKGRNEGKYHGLPLLNTLNTMSRPQTANEIRSEIREISEVDCLVSPTYIGTPSVVRAYTPHGQANQTRRASYAQSNATTAVPSEQSRLSSPVTPPKTSSAASEKRTSDSFGTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZC1</accession>
    <name>U4KZC1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pre-rRNA-processing protein TSR2 acc. no. Q06672</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935376">
        <property type="protein sequence ID" value="CCX07805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZC1"/>
    <dbReference type="STRING" id="1076935.U4KZC1"/>
    <dbReference type="eggNOG" id="KOG4032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LAKDEWF"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
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    </reference>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="10" mass="1146" checksum="2A42FFC775B9D408" modified="2013-12-11" version="1">MPGRFSPQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L192</accession>
    <name>U4L192_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="HF935434">
        <property type="protein sequence ID" value="CCX08887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L192"/>
    <dbReference type="STRING" id="1076935.U4L192"/>
    <dbReference type="eggNOG" id="ENOG502S2ZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX08887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="39570" checksum="3A5780F12E1C2FFC" modified="2013-12-11" version="1">MPHEKDNNYLSPPTSPLNSGFDTIESPLPSPAFSYQSGDDFSSPYSPYGHASQTHANTLHQSFGADNLTRTISYDSPGSPSIKRSGTKKSAKDTAYFKEVFSVRDEPVVPKTAGIWVEFQTNINLHNTPTLLTSLTAYLAHRYKVPPLTILLDISHSSHLSLGGTSEGCYTLTVSAVHSISPTVNKRQAIMLQQWIWENLGLAANRGIIRFNLVECANWATGGDTVLGTMEKEEVKRTGTNSGMIRGMSRRGGSRKEKEKKEGGLRGFSRREKRGERIMEEEGMMEDFPVKETGGKMEQKGLGEIEREMEKMEVEDLGKYSQETLADERPKTEQKPADKPKRKKSVFDIFSRGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1D0</accession>
    <name>U4L1D0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="8">HIU hydrolase</shortName>
            <shortName evidence="8">HIUHase</shortName>
            <ecNumber evidence="8">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="8"/>
    <dbReference type="EMBL" id="HF935407">
        <property type="protein sequence ID" value="CCX08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1D0"/>
    <dbReference type="STRING" id="1076935.U4L1D0"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CSENQNY"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="144" mass="16075" checksum="2C50ED0D8F82ADA0" modified="2013-12-11" version="1">MSQPSSASQRLETITAHMATTPAEKPPVTCHVLDTTIGRPASDIKCTLLQFPEGKLGIEATADELATGTTNQDGRVTSWSGEKLKLQDGAVYKIRFEVEEYFKRSGQETFFPFVEITFRVRSTQEHYHVPLLLAGWSYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1M4</accession>
    <name>U4L1M4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1M4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="8987" checksum="A77F640F4551AFA5" modified="2013-12-11" version="1">MHRHGEFTAGHWGFRSTSADHVVHNSTESEDVDITSLSVSCSPYILCMLFELCMLCELLCNIREAAPSGTVGFVGPRVPYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2G6</accession>
    <name>U4L2G6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2G6"/>
    <dbReference type="STRING" id="1076935.U4L2G6"/>
    <dbReference type="eggNOG" id="KOG4546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTWQSTY"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="334" mass="37868" checksum="6BF7A81BAD23910A" modified="2013-12-11" version="1">MAARLNKTTQLYADFITKNAGAVSQIESALRSLTYIVPARFQDAELASEAVHSSISLLSLYHDSLLARSISSSSTPNKPADKPTPHNRYTRFWTKQSPSYRRLALLITIIQYTELLWEMTSQRRGQRTKWRVIVTLEAAKAICRLWLLKLTQSRPLLTPPLPERELIPEEEENLGPVDISGDNSDADSISEKKQEEPWQMPRTGLSLPSLPDPNKISQYLLSKVLTPEDVKPPQQLLHRVKGLGYLAEVVYIIRPVVYAVALMKMRKDKKSWAPWLLGFSLEFMARQLRKRELEQGVPGGLRGLTGLEKDELSRRAYAMAWWGVRGAAYENVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Y7</accession>
    <name>U4L2Y7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="HF935201">
        <property type="protein sequence ID" value="CCX04400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2Y7"/>
    <dbReference type="STRING" id="1076935.U4L2Y7"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDLNMQV"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000100">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF2">
        <property type="entry name" value="HISTIDINE KINASE M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="524"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="720"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="866" mass="95721" checksum="6561438C093EE731" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L360</accession>
    <name>U4L360_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Thiol-specific monooxygenase acc. no. Q9HFE4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L360"/>
    <dbReference type="STRING" id="1076935.U4L360"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VMIKEVN"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="476" mass="53099" checksum="1C8794E596FE8909" modified="2013-12-11" version="1">MSTILPSISRVAIIGAGAGGLVAARALREQNHFTKIDVYERRGDVGGVWNYTPQSASVHVPSTDVTRDEEPVEVEIDGNGNTMKKRVWVSAMYNSLETNIPKTLMCYPTHAFPAELPLFPGHDAVCDYLKDYAKDLRDMITFNTNVTHITPSESGSGWTLTLSTMPQTWKSPETSETLLETEKEEKETYTLTYDALIIASGHYNTPFIPSIPGITSTHIPLEHSINFRLASTYVGKKVILVGNSVSGLDIASQLLPYVSHPLLQSVRTAPEHPDDSPVIKTVPQITEFRGHNEVVFADGTVESGVDLVLFCTGYLYTLPFLNPTPSSSTGERVTGTWQHLFSIQHPTLAFLGLPMKVIPFPVSQSQAAVVARVFAGVTKLPGREEMEEWERKRVMECGDGKGFHNFGYPKDVGYMDWLEEMAKGPGLQPTMWREKERWMRSLTPEIKRDFGRAKKQGVVVRRMEELGYVFEESSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3D8</accession>
    <name>U4L3D8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935511">
        <property type="protein sequence ID" value="CCX10093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3D8"/>
    <dbReference type="OrthoDB" id="10395219at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4856" checksum="A3ED1D5AE696AB8A" modified="2013-12-11" version="1">MACHESTALINHTKESTLSTVTKPPTKPCWCGDDCSCCVIPCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3H0</accession>
    <name>U4L3H0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Ankyrin-3 acc. no. Q12955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3H0"/>
    <dbReference type="STRING" id="1076935.U4L3H0"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX11121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="404" mass="44278" checksum="EC13F549A19B7F8F" modified="2013-12-11" version="1">MQPTDTKKLSHLPPDLIYCITADFPPQTIFNLVLTSRQLAQTLLPVYYRLSAPYPAAVLQAASKSSPYLLENLLYYGASPDTTDTYGFSGLDIASRLGHNHIITTLLNYGAYLHVCKGGRQPYSLFSPLDYAAKHGHVETFSLLLSHLFARYPEEEVNEAVGRALQHAVQEKRASVISWLLTYVPPSQAHLQQALNKVVNSNLPNIAQLLLSAGADPNTLAPDQPTTLIHRAAERNRVELVELLIEAGAEIDVKDGVGLAPLHYAVKGNAVDAMELLLEAGADIDQTSTFGTAFSGAIRKNWSTGVEVLAAWGIAQGWDVKERWQMLRRQRKGKAVEEAFLRAVGAALGEEKVNECIDSESETVLSREFQGAQMQANQFLSPLQQSTKSPVNPSRLCRIFTGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3N6</accession>
    <name>U4L3N6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Palmitoyltransferase akr1 acc. no. Q4X251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935519">
        <property type="protein sequence ID" value="CCX10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3N6"/>
    <dbReference type="STRING" id="1076935.U4L3N6"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHEQHHP"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="322" mass="35738" checksum="C51D42FC4134165F" modified="2013-12-11" version="1">MASNPGTTTRAPPMFVSQKAKAAPASVDTEQVELRDMIASAPPPQLALKDDIMKLSMHGDDIGLKALLDTGNVSANFQDEEGLTPLHWAAINNRYSAAKLLLDEGADPNSHGGDNDATPAMWAAQRGNYYIVNLLLRNGADPFLCDEAGYNLLHLATFDGNVLLLVLLLHQGIPVDSRDPQNHTALMWAAYKGYANCVDLFLRWGADVRAVDEAGFSALHWALVRGNYGCITKLLEYGVDRFQLNNEGKSPTVVSQELKTEKVWLDALEDTGFDRHCHPKHKPNTFFGIHVNDKDFAMKRFFFFGHFWRFRLSYNVCAICPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Q0</accession>
    <name>U4L3Q0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX10676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="37" mass="4102" checksum="71796BB6B8BF4811" modified="2013-12-11" version="1">MGLVWVSLAVCCLRDGGDAAELHAYMHKLRTLDPMDL</sequence>
</entry>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="16">CBS 100304</strain>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX11769.1"/>
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        <source>
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    </evidence>
    <sequence length="818" mass="89755" checksum="AE3993404E5E2047" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="360" mass="41371" checksum="423FBCA450A2B9AE" modified="2013-12-11" version="1">MEFKVEEKLQTSSPSAWYFEARTSSTKNQNPASNDKIDKTGETVFNAESVSRFGDCDIPVSVHETCFMENKIDRFIIDVTLKNYPENRDNGKQIMIQLKGLIANIRSILHLLDSQMTTLKQLRDIIKKGYHAHFTPSNGYHDSHLQLPFRLQGFPTLRVVLRELEILIAESKEHTKEFQKLIRSLEQRQTTYIIFHEMNASTYRVADTLKTNINEAIEKNGLYRSKSTEKVLTALNKNNRHRNTMTQKVLGAAHQNLGSRKSATENIVESMDKETKSVQEHKNIALMTSQTMSMFTVVTVFFLPLGFFCSVEPPHHSFDSVRWPSSYGQYFRATVHKIPIRTSTLEELISTLTLSMISHH</sequence>
</entry>
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    <accession>U4L648</accession>
    <name>U4L648_PYROM</name>
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            <fullName evidence="13">Mis18 domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR034752">
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    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
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    <dbReference type="PANTHER" id="PTHR16431">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="121"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="464" mass="51849" checksum="EAA4490D2EE24FBA" modified="2013-12-11" version="1">MPLQPITPDLLSTIPSTPTPSTTFPSITFSCSSCERILTDSSHLLCQTQHRSLTFHHLLCSISTERHFSSSGWDENTVSSQICCQKCNQLLGRTFFGTPNHLVHLQGAFTVDIEKVLVYYVGTQQPPQRVLEDPEVIALLNPQPNEVAKQLQGLKTVCVVLSEELGEVKEELAQIAKGDTAQLLDRIGKLEQQGWRQTEEEYANSGAGGGGDTTQLLNRIGRLEQQILKQTEESGAMLAAMKKERVEQEKAHKKAMQKLEQQREELLVDCARQVEEVKAHFMGILHSLELGKSPLQELVQGENTTQATSKSHKRKQGATPQQESQVKRAAIVISPPSTVRSVIPDSQSTDGGLSFLEEEGGRRRSLRSEQIGSQPSHPIEIMEETEKRGRVRSRKSGVVWPDLEPEGPVKKQGDSEMKLKETLNEETIETRGKRMSQSIEIVMTEKQKTTRSTRRSGNFQQLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
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    </evidence>
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            <dbReference type="EMBL" id="CCX05520.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="566" mass="61889" checksum="6954FE228962C403" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6F9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5445" checksum="C4C66D5919EDF695" modified="2013-12-11" version="1">MQILIAYTTLYNTIPARSSHRCLSIDFYRDEDHQVGLMSVLPIPDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6L4</accession>
    <name>U4L6L4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6L4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="427" mass="49227" checksum="988AF8059F8D9592" modified="2013-12-11" version="1">MALLMRKRTGRDSNTTAMNSKATSKYPVSEITKDFIQILTGQSAPTHTSTSVYGIHAVISTIPLDIQFYLQCAVLYSDLLTLLYWFRKPMFGGVAPGAQNETTGTMREVRAQKAQYFRVLNGAFQCYRDILDSVTNDNTWVVEEWRYWKCKTLRRKVSDQLKFERQRYHDQDLLSTSSSTFQMQAQTLKDILATQLHKLLQEVKKSQNGCGLEELLRDIAKEITSVNSKFHLSKYIDFAKKTFIPGRGTIEEKTIALDILRLSTLEDIINCGGVGWILRMDPLDSFKSEVSVSLMFNLATDKVLRILFLEFKRYDNEAVYKRTISYNRKRALNIFDDHVSRDRSGQQCQNGAVIYNDLLGTLYQFRPSVCTEAFVTANIQQIKQAQDHLRTVLERAEKYWGGWDSGSERCINSWKDLRKQKRKISTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6Q4</accession>
    <name>U4L6Q4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935721">
        <property type="protein sequence ID" value="CCX12625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6Q4"/>
    <dbReference type="eggNOG" id="ENOG502SUJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="444"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="587"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="712" mass="80741" checksum="84FD37978369BE10" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6R2</accession>
    <name>U4L6R2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6R2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="246" mass="28544" checksum="0ACA409D4C9B8CA8" modified="2013-12-11" version="1">MSGINKLFQDLEQSSIEKQNALNENKRLKEELAEVKKQLSNAQEKIRTLQDDNERSNTELTAATKRFESFEENLQTVSKRLNDPQEKLQTLQDENSCPNTELAVVTKQSMDYREKFQTLQDDYINQGQARPLMTMQEVCETMEKVQSYLIDNIDRFASTQATVENMEKRLLAMDIKLQASETARNAFDDIKEQASKEQMVEDQMKVQAKIEEIEKRLVDMDSDIKRQASETVHKVEDVKELVVDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6T0</accession>
    <name>U4L6T0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to BRCT-containing protein 1 acc. no. Q10337</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6T0"/>
    <dbReference type="STRING" id="1076935.U4L6T0"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWLYHLI"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="364"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="585"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="800" mass="89415" checksum="27C601E722C44025" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6W5</accession>
    <name>U4L6W5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Isoflavone reductase acc. no. P52576</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6W5"/>
    <dbReference type="STRING" id="1076935.U4L6W5"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YHSKLAI"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32642" checksum="101FE4B717D8B93A" modified="2013-12-11" version="1">MYILRNVTLLGATGSVGAPVLSALLSTPQISVTVLARPSSSIAQNPPEGAKVVICPDFSHETLVPLLRGTDALVITAGTDAFTLQHTLITAAVEAGVKRFIPSEFGSDLNNEEVAKLGVFQTKISVRKELQRLAEEGKIEWTGISNGALLDWGLKVGFLGIDVKNKKARLFDGGERRFSATLLSDVAKAVVGVLMHPEETKNRLVYVHSVVLTQKQLVGIYEKLLGEKFETTVESTEKIKQQGDEKIEKGDYSGFVDQIIRALWGPNSGSDYGEKVDNELFFIEQLTDEQLEEVVRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7J4</accession>
    <name>U4L7J4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Kinetochore-associated protein MTW1 acc. no. P39731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935434">
        <property type="protein sequence ID" value="CCX08879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7J4"/>
    <dbReference type="eggNOG" id="ENOG502S72R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYKDIDF"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37597" checksum="010FC7A665B91E26" modified="2013-12-11" version="1">MTTPTAASTALLTEHFGWTPLMFIDDIINTVNAIANATVSSVETFLFSQRPELLGFKTPPGQTREVDEDGQTLFTEQEEDELRQGVHKLETLMDNAVDTTFDKFEIFLMRNVLVVKESLVGWCRLAHYKDIDFSGFIPSSSSSEPPVDSMDLSSPPPPGSAETAALLALRQRLFASTHLSLSLQAEKAENALVLSKLRELASSLSPSYTGPVTSFSLLQGSGKLKEGAEFALSQVGAVRERYEELGPRLEELKKVKEKEASKEKESMDGAEAYTERGVYLETFKKAQMEALRRERRRVFYGQQERGVERGEEEVRKLGEIVGMMGGRSDLSHGEFWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7M4</accession>
    <name>U4L7M4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7M4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3406" checksum="B0A40AF8B4ED6DF0" modified="2013-12-11" version="1">MRSTNPGNFLCLEQASERFTSFAPSSFSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7R4</accession>
    <name>U4L7R4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7R4"/>
    <dbReference type="OMA" id="PRICPRK"/>
    <dbReference type="OrthoDB" id="10448243at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="537" mass="59249" checksum="24FFF9916371BE11" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L809</accession>
    <name>U4L809_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935839">
        <property type="protein sequence ID" value="CCX13421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L809"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="34406" checksum="DF63B3060626D72E" modified="2013-12-11" version="1">MTLLTWKPCDNCREAGRELTGLCFHYTPDPTEENPMFHGQFVPNPRREGAFPNPWTFLNNGRFLGNNLGDWILLGYGLQADPFQIATHILHSPDIRIKDGENGSIYGRGTAILSPYITFSGNVMYDSPNKRYIIEFEGPNFLFWREKLTKRLIIYCNADSAEYGTYRNGSTMTWIGGLHTSRPGSVRYEMKTLGGRLNWTWHGPWSEITTVEMFKKRREAESYDRLMNCWKKCRRGGPDTYSNGLFGLDLRKAGSISDKLVPDDGNMEDVGTFGNSSAIIATALRAFAYEGPWSKSISSLNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L883</accession>
    <name>U4L883_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Universal stress protein A family protein C25B2.10 acc. no. O74782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935468">
        <property type="protein sequence ID" value="CCX09517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L883"/>
    <dbReference type="STRING" id="1076935.U4L883"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHIYEPV"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="118"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="357" mass="38717" checksum="CF721828CFF124C7" modified="2013-12-11" version="1">MTSTPPPNEATPRNSVDKDPRRTSIAWTKLPEVPLAEGRRQTSISVTASASAPGTPATGYHSSGSGSVRTGRSLSSPPPPPAFQKRVSFDTFDNRDATDFSLTLKSKHRDYSYSRRSRTFLCGTDQNDYSEFALEWLIDELVDDGDEIVCLRVVDKDSKISSDQAMQEKLYRQEATKLLDQIIEKNEDEKAVSIILEFAVGKVHETIQRMIHIYEPVILIVGTRGRSLGGLQGLLPGSVSKYCLQHSPVPVIVVRPSSKRDKKKAKRRADPSRKVYADIMQSSGLMIHGNISGTTEIGDASAISLNSTEDPNSYGTSPKTVSMTTSDSPSPVGGGVALDGAMNALSIASPRNSTETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L887</accession>
    <name>U4L887_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Secretory component protein SHR3 acc. no. Q02774</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935776">
        <property type="protein sequence ID" value="CCX13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L887"/>
    <dbReference type="STRING" id="1076935.U4L887"/>
    <dbReference type="eggNOG" id="ENOG502RXJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANMLFDG"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="20619" checksum="66B9582196C1A3BE" modified="2013-12-11" version="1">MTGSTFATFLVICPTSFFLGILFTNWVYDHHTLWNSTGASDAIYAAVETHYSMLARAPPILPRTLHAIIFTGLIGFFIKLYRPSESNMLFDGSSLVLFMIGIIMYGTNVIRGLQTVESGDYGEEIGRIDTMRIMAASHVILALVLVGVLVLQSGQYYAERKALQERTKIEEEDKANEKKTKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8K8</accession>
    <name>U4L8K8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8K8"/>
    <dbReference type="STRING" id="1076935.U4L8K8"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX06479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="304" mass="31701" checksum="EBE92940F60FEBE5" modified="2013-12-11" version="1">MTTLATPAAAAAPTLSPAAIIEGAKRLAAYRAVDEHFPQNARYVGIGSGSTVVYVVERIAQLPRDRTDHVVFIPTGFQSKELILKAGLKLGAIDMYTDLDVVFDGADEVDPFLNCIKGGGACLFQEKLVAISGRKFVVVADFRKLSPSLSTHYAPGIPIEVVPPAAQYVLSRLVALGSTGPTIRMGGASKAGPCITDNGNFIIDAPFQDGFIPASASPRPISPSVDAGLGERVGGSDVLGKEEGHPGAAVGMGVGANEHVEELAKTLKSIVGVVEHGIFWGGDKKPVMAYFGMEDGSVAVRGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L996</accession>
    <name>U4L996_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935310">
        <property type="protein sequence ID" value="CCX06759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L996"/>
    <dbReference type="OMA" id="FATYEEP"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="484" mass="53381" checksum="0B37729DD8C6FB35" modified="2013-12-11" version="1">MTSAVPVHTYHPPRHPHTVAPTTPTPIPRSSTSTSVYTTSSSSTQNTTYWPNNGGSSLSTASSSSPRVNAGLAAAQYVTGRLHRRARSGNNTPDEIPDEMFDEGFFSGPGSPPPTEMFSKTMKPKNKIKPLLKKVSGSRGNSLDLSRSDGGLPNGVGLGIFDNPDSGVDEDVLDTAFPKYTRQRHSRNISGLSSTSANSPLIAGTNPTQPFAHPKRQVPRQRHSYTTPDLSRDATSTESSDGSEEDETETRRIVRTGSYVQDLKVRTSYESHTTPLATTSTITEIERPSSQLITPVTPVSPQDSIQEVKQRRGRASLKPKESKIREASPSFADSVTAARLAWEAKEEKKEEKREKKRRRMEAKEQERSASQNSHRARVNSGSSAYTWDEETAEGYREKTGMLEEEEEEDDDEVYTGRGSLDPPQNRNSLQSTRGRNATGKKWGVLNSDQNKPGSRKSGSLKKKWLGFIVWVRIGMVRLGRKMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9K5</accession>
    <name>U4L9K5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9K5"/>
    <dbReference type="OrthoDB" id="10395252at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="203" mass="22445" checksum="22C9117D6E2440DE" modified="2013-12-11" version="1">MSHYYHHRSRPTSPWSPAIQYLVLIQLFLAFGLLLDSAWQWLNVESLNGEDRERGIMNKMMFFASMFTTFSAVCNITSSPESLAVPEVVVPDRISFALWAMLSGKMVMEMGTFDDISSLVNLAVKLVLCAVLVGKLVVAAVVCERNTNSDEEEAVTEHHMAVLSVDDKLDVYVISEPRSESGDEIMNCNGDDGNGNGNDKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9V6</accession>
    <name>U4L9V6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Protein HOL1 acc. no. P53389</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936188">
        <property type="protein sequence ID" value="CCX15514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9V6"/>
    <dbReference type="STRING" id="1076935.U4L9V6"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MWTVRKR"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX15514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="652" mass="72538" checksum="996384437FCCED87" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9W2</accession>
    <name>U4L9W2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9W2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="16" mass="1915" checksum="A04407183A7CE72F" modified="2013-12-11" version="1">MQPLSTLISKSYDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAB5</accession>
    <name>U4LAB5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAB5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="8084" checksum="F68F242D99959D00" modified="2013-12-11" version="1">MDRSLQSHKSQVHDRQVSLYHDIRYLHIRCSLGIRLKNIATRETDSKKRLKHERAQRIDPNGNPTFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAE5</accession>
    <name>U4LAE5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAE5"/>
    <dbReference type="STRING" id="1076935.U4LAE5"/>
    <dbReference type="eggNOG" id="ENOG502SEMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="15854" checksum="2B3FB83BBB41C558" modified="2013-12-11" version="1">MTTPQVHTYHCTSCTVFLLASTYNFSTLPVRSSPGLDSATIIPFPSLVTNPNSSSSHSEPTADFTVLLGLVKDRDGSHGTSGGPGGSGGKVIVAREDGFEKRALYRCGRCKVVVAYAVEGKGWLYLLPEGWVETGRMEREAGERREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAY5</accession>
    <name>U4LAY5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAY5"/>
    <dbReference type="OrthoDB" id="10503167at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="14757" checksum="39BF9510AE81CA3C" modified="2013-12-11" version="1">MSSRRPSSFSKSSNSSSSLSSPTTSPISRVPRTNSNGTPRRVTLVEPEKPTKHEQLSEEPCKSKRKKALKVVVDGVSIVAHLLCMCCVLSGEQRPKNGAYYAHYDEDECRGARKVQQSRGNTHPNMKQRVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB20</accession>
    <name>U4LB20_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Uncharacterized protein C23C11.17 acc. no. O13920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02932</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB20"/>
    <dbReference type="STRING" id="1076935.U4LB20"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LQHYWDG"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="221"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX16336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="485" mass="54863" checksum="B122BE4F7B2827FC" modified="2013-12-11" version="1">MNSTRLILNSAVSRTAVSGATRRIAYPRNATRIGLSSNRPQLPRHTASLFICLRDLSTQTSSTPGAAGAPPPGFNIEEAKRPLPKALAENKSDGSKPGKPEDPPKEIAAKDLVKEEKKKETVWQKVKHGIQHFWDGTKLLGVEIKISYKLALKMAAGYELSRRERRQLERTVKDLGRLVPFSVFIIVPAGELFLPIALKFFPNLLPSTYEDQKQKDAKSKKLRSTRKDVSEFLRTTMKEGGILPIGAKTRQSEEFAEFFKKIRTSNLKPSREELIKVCKIFKDDVTLDNLSRPQLVGMCRYMNLNTFGTDSLLRYNIRHRLRQLKRDDRAISFEGIDSLSIPELQSACMSRGIRTHGVSPARLREDLSTWLELRLKHGLPSTLMVLSNAFMYAQGKETELDSHYDALRAVLSSIPEELYHEIELEVHAAEGAATNKQRLEVFKEQQEMIEEENEQRAETGHKEPTDEKDIDEKMGIAVAEEKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBC9</accession>
    <name>U4LBC9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935619">
        <property type="protein sequence ID" value="CCX11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBC9"/>
    <dbReference type="OrthoDB" id="5459133at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="314" mass="35604" checksum="244628A2915BDFA6" modified="2013-12-11" version="1">MSPQQWPLPAELGLDANDPFYSLYTVLYESYQAFLTATTTLENDLHILRRTNSELIAKLENKESQIKLLEKFTKTQRSAEQEREEALEELRKTNLAKKEIQEQLVNFAKRNVILLNEITQKNKEYDQLFVKFENAKDYALEELEELRKEVEETKNLAMEKQDELENLRRTPSTALFDADVGSILSSSTIGRELSYSANDHTEDDFDNRTLVASTLRSGRYGHSGSRRTSASLSRKTSQDTIRTSTVSVYSVVTSPSNGAQSPVPKDLHPLGRRGSRSVFSLSLNRNDSPTPTVNTPDDNDMAVNVGLWGRITYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBQ8</accession>
    <name>U4LBQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935633">
        <property type="protein sequence ID" value="CCX11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBQ8"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="311" mass="34917" checksum="EB72AAB38CA88806" modified="2013-12-11" version="1">MDFTTNNFYNPNLEFDPAIYNFFTSEELAGFEPAMYELQQSWEASGMNPEAFLQQQQQPSKQFESCGFQQQQQAEMNYPSFNFFTDPSFFSCDFPTTTCDSSSDASFDFLTSPITPSSSPLQCQTQPNYFDSGVHQQFTYPAFPIPTNDCFGFYDYDIPSQLEIPSLTTSPAHSNGVSPALQFQSHLNGLQFGGDNLVDLTGDSDMGSNCSEVDDEEAEEEDEEAEQESLVPNHGNKELRGMGLYDDRVPGASSGLLWGTSGALVLERSFGLPEKMMIKGRNGEIIEGRLQVEEEDEEEDEEEEEDEEMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBS4</accession>
    <name>U4LBS4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_07346</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF935374">
        <property type="protein sequence ID" value="CCX07757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBS4"/>
    <dbReference type="STRING" id="1076935.U4LBS4"/>
    <dbReference type="eggNOG" id="KOG0326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="74"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="254"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="419"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="476"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX07757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="546" mass="61479" checksum="44E5D80E0A573ABB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBY7</accession>
    <name>U4LBY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Splicing factor U2AF 23 kDa subunit acc. no. Q09176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936522">
        <property type="protein sequence ID" value="CCX16799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBY7"/>
    <dbReference type="STRING" id="1076935.U4LBY7"/>
    <dbReference type="eggNOG" id="KOG2202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX16799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="211" mass="24438" checksum="CA4CCD8ECEB81269" modified="2013-12-11" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILLPNLYQNPAFDPKNKMNQSQLQNHFDAFYEDFFCEMCKYGEVEEVVVCDNNNDHLIGNVYARFKYEEDAQTACDALNARWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKEPSKDLETELELSMKKWLQMRGRDKRSVSRSPSPGGGKRRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCA5</accession>
    <name>U4LCA5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized protein PA3568 acc. no. P28812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936658">
        <property type="protein sequence ID" value="CCX17468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCA5"/>
    <dbReference type="STRING" id="1076935.U4LCA5"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDNWWST"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX17468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="654" mass="71169" checksum="0F9BD15C255C3322" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD23</accession>
    <name>U4LD23_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD23"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4797" checksum="1A855BC969A9E2F5" modified="2013-12-11" version="1">MMIYFITGLLGYPTYSTVNPNSTKSEICRGLLRNIKTLLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEN2</accession>
    <name>U4LEN2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Putative ankyrin repeat protein RBE_0317 acc. no. Q1RJR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_08450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEN2"/>
    <dbReference type="STRING" id="1076935.U4LEN2"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEARTHA"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="253"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="544"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="862" mass="96549" checksum="52221A18610BD84C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF40</accession>
    <name>U4LF40_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF40"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5359" checksum="B7B4D6B9A76F162E" modified="2013-12-11" version="1">MNIGTVKTDTGTAEPGPSISTSGTSRSIPGSSRRIPGLSMPITDRQDERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFB4</accession>
    <name>U4LFB4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935431">
        <property type="protein sequence ID" value="CCX30237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFB4"/>
    <dbReference type="STRING" id="1076935.U4LFB4"/>
    <dbReference type="eggNOG" id="ENOG502STDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4869816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="25283" checksum="D9B423CA4052200A" modified="2013-12-11" version="1">MTQFTDLSISPTEGLRITLHNLPSSPPCQNPGYVPSRTLRPHLHPSSKPSTPPTSPALGFLALRTFYSNPSLWSQFQQHFTDLLSSQLTPSNGTGIPSVVNEFQIIWIEDPSLEEASMEDIRVYVSNMKERGSVPQGMDWSMVLVADEAAAVSVVEALKGQKSKKAVPWVIGLDVDYGEGEEEEVYEGFFKVAVQTLLTELFPVLATQMMAPSEMVAGIDWELGVWIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFQ8</accession>
    <name>U4LFQ8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFQ8"/>
    <dbReference type="STRING" id="1076935.U4LFQ8"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICEAQEH"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="280"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX10478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="447" mass="50969" checksum="3933BE9D25220BB4" modified="2013-12-11" version="1">MLTKIKRPASSAIRRFTNSNYTINNNGGKVTRGVQTALATRYQSNTRWRSSTVLDDWVAKPARPISLRQLIFFGGRGLDDKRIINSANYVRTELPTRLAHRIRDMQKLPYVVVTNKHLSYVYDLYYSAFDSFRSVPHIKTTEDNDRFCTKIKAALKEHLTVIPRLAMGVLECRNLLPADELDKFMHALLRSRISRRVIAEQHLALTDTFNSPFHFNDGRNYQPGDFVGEVFLKCKAQEVIRRVGAYAQELARKAHGPDCPVPEIIIEGHLDTTFPYILSHLEYITGELLRNSIEATIEHHGSKRELPPIHVLICHAPKHVIFRVSDQGGGIPADETKDLWSFAKSKRSDDKRLRNFAKVPKMAGTLQELQEGPPELRDHEGSLSSLHTLTYRPPDLKLGMGLPLTRVYAEYWGGSLEQTSMEGYGTDMFLHIEKLGNRLEQLNVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGN6</accession>
    <name>U4LGN6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Maintenance of telomere capping protein 1 acc. no. O94548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGN6"/>
    <dbReference type="STRING" id="1076935.U4LGN6"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIHLVHD"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="447" mass="48032" checksum="5387AF4FB5627097" modified="2013-12-11" version="1">MSKSKHNDGLDDLFAGLPETVSTPPLKAPAAVDDPLADLDELESLAERPKPAALSRPETPRSAPKRSLSRSRTPGSGYGMPLSARNSLEQKRSEKAVTPPESPAKKDVAPASGGGWGWGSLWNTATTAVKAAEGLVQEIQQSEEGKKWVTQVKGNVDGLRGLAGEIKSTAIPTFSSLLNHLAPPIASHEQLRIHITHDLQNYPFVEAVVFGVFDRVMQQVEGGDLLIVQRGGASKPRSAEGTFGGGPWWKAMEKRELNACSGLQEGLKLAKAAAESYASEHAKAAAEEAASNSQNPTRKSNIFLSIQPTVHTMDALVASVTGESTGDEEKVVSFAIHLLDPEHEISFSTLSQSLPLQWLDWLNAPPPADAQQGQWALPEVIQDIMQIGGTDPREWVVEWVEETVGLSVGVVAQKYVAKRMRIGDAAEAGEEVRQATREQENAEGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH17</accession>
    <name>U4LH17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized protein YKR096W acc. no. P36168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <dbReference type="EMBL" id="HF936243">
        <property type="protein sequence ID" value="CCX15608.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH17"/>
    <dbReference type="STRING" id="1076935.U4LH17"/>
    <dbReference type="eggNOG" id="ENOG502QRU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWSHAFY"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="3">
        <location>
            <begin position="889"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX15608.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126850" checksum="305BA1AEBDA9A514" modified="2014-03-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHI2</accession>
    <name>U4LHI2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHI2"/>
    <dbReference type="OrthoDB" id="10373571at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="238" mass="26263" checksum="A9FD85516D621E5F" modified="2013-12-11" version="1">MARNSVDNSPFNPGADDTSLDRLTPSPRVFDSIWSPASRSHLMRPTEITVQGPPPYSATNPDFNEHDVSVTADELHREPGMLNRRLETSKIGSSNVSSDSEVEGKSGSEWEVVTPSTENENPLAKATFKAAAEIIMEINKQHKLEPHPDDDLVQLRPEVREELERLLALVGEGLKGLWGLLVRQETPRDMALVIVAAVRVRIADWKAGRVAPALAEVNGDDKKEVEMADEKTEVQGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHK1</accession>
    <name>U4LHK1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Probable quinate permease acc. no. Q2U2Y9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHK1"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICTATHW"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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</entry>
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                <person name="Marcet-Houben M."/>
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        <source>
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    <sequence length="461" mass="48235" checksum="BDCC35E85E728FC2" modified="2013-12-11" version="1">MVRRLSEFKQKLHPNAKLRAWYQSHTFGGTTKAKSLKILGFSKQNFYYVAAGVAALLIIAAVGGGIGVKTSLRSAKIQGANEGIVGQPAVAKTTQSRVRTLVSNGQTILKTETTAYVTTFTRGAGITQVVTTNEKGEKTTVQASMKLITNSEGSFETQTLIGSLTLVPGQGGVSEQTIVFGEPSVITNDQGQLITTTVFNTDNSQPTGGTAKDSTTAAATATPGASPTGATTGAASTNTAAATSTAATSSKSDAKPSTSASPGGGDGGGGGGEEFEGEATFYAPGLGSCGTDATDADYVAALSKVLFDATGVKNSNANPYCGRKALVKAAGGKRRRWDNLWNMTTHGSENWEKSRSERWSRRSMISAGTDGLDHPTRAWNRTKNRGWDIQFEEPAPPGITPPPGPETDLWERQAGGGGVTITVVDRCPVCKQYDLDLSPAAYNVLGNPDAGRIAIKWKWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI18</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI18"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="26" mass="3020" checksum="040A2FBFA25C6605" modified="2013-12-11" version="1">MNRGLGRFSPFPTHPSLYLCPLPYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ29</accession>
    <name>U4LJ29_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_12030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ29"/>
    <dbReference type="STRING" id="1076935.U4LJ29"/>
    <dbReference type="eggNOG" id="KOG4777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="357" mass="38408" checksum="D30513C5615F48F1" modified="2013-12-11" version="1">MVDQKKVGVLGCTGSVGQRFILLLSQHPYFKLHAVGASSRSAGKKYKDATRWKQSQQLPEEVKDMIVQECKAAAFAECDVVFSGLDADVAGEIEAEFIKNDLVVFSNAKNYRRDPVTPLMVPLVNTNHFDIIPHQRNVKGLNKGFLVTNANCSTTGLVVPLKALQDKFGPLDAVMVTTLQAISGGGYPGVPSMDILDNVVPFIGGEEEKIEWETGKILGAVNADATAFTHVEQTKVSAQCTRVAVMDGHTACVSVKFGGAKPTVEEVKAAMREYSCESQALGCPSAPKMAIKVFEEEDRPQPRLDRDLEGGYAVSVGRVREDPVFDIKFVALSHNTVIGAAGSSILNAEVAVVKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJE8</accession>
    <name>U4LJE8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_12552</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935733">
        <property type="protein sequence ID" value="CCX32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJE8"/>
    <dbReference type="STRING" id="1076935.U4LJE8"/>
    <dbReference type="eggNOG" id="ENOG502SCC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWQGASQ"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="26810" checksum="F8C7CA20FE2A05D5" modified="2013-12-11" version="1">MADADHEMSDFYVDEEEQLEAEQHHAQTLLEEQAQKLRTFGTNATSVVDADAREEALKEEIRRVREVNDVIETLVNSMEISQGNMQHIHHTILNANSLLSIWQSTLSQTEHTQRILQSESWHGSTSEAEELAAEAAARQLNIQRRLEAAREKGAQREREVAAEEARRAVVEAQKAVAGARGRGTGTRRGATRGAAAAATRTGSVYGTRSGSATASTRETRSMRGGTVRGSYGVARGTRGGVGRGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJJ1</accession>
    <name>U4LJJ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative ankyrin repeat protein MM_0045 acc. no. Q8Q0U0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJJ1"/>
    <dbReference type="STRING" id="1076935.U4LJJ1"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INPTHTA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="216" mass="23250" checksum="A9579E88D774E2A3" modified="2013-12-11" version="1">MSNTNNSPTSSSSNPSEGSGDFFLDDSTPPPPTELFDAVNNNDVTTVELLLSEGDPIESKNHLGQTPIITASALGYLSLVELLISHGATIEAVDKLGYTALLEACSSGHSLVVRLLLDNGANIETRQPRYGRTPLIEAAKGGYEDIVRLLVERGANKEARDCQGKTALLWAARNEKRDMMNLLVKLGADMEARDGEGKTALEIAKRVEESSDDSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKA8</accession>
    <name>U4LKA8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKA8"/>
    <dbReference type="STRING" id="1076935.U4LKA8"/>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YNTQNVP"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="6869" checksum="6A32F0D20736CC1D" modified="2013-12-11" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKPKQPKGRAKKRILYTRRFVNVTLTGGKRKMNPNPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL96</accession>
    <name>U4LL96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YGR017W acc. no. P53210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL96"/>
    <dbReference type="STRING" id="1076935.U4LL96"/>
    <dbReference type="eggNOG" id="ENOG502S535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DCPTFTT"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="298" mass="33153" checksum="77C5DB7A8FA836D9" modified="2013-12-11" version="1">MPQPPWKPLLIQHLGTLNPPNFALATISSNAAPLNPPFCPPGAMHPPPPSIPSLVPRVRTMIYRGFFGTLPANPHTPLPNHNPPIMTSDMLTFTTDARMTKTGELTPDHTSGGDATRGTCGGAEVEMCFWMEEPQNQWRVRGRCYLLAEEDVDTSHEIQEELKKRMEFSPEGDKDQWSWKKEVQAHFANLAPAMRGSFSNPPPGTPVNVDLSQLENNTGGGEQLKKGTNVKNEDVLKMGGPEEIARRNMRVGVVVPEVVERVDLAADDKTARRWVWWFVGEQEGEGVKDGWKEIETFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLM3</accession>
    <name>U4LLM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX14283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LLM3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4863" checksum="830CD6A6E107210C" modified="2013-12-11" version="1">MPSRLSETLPTLQTFVGSPLMISGSSLSTKRHGVTESSVTRHGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLX5</accession>
    <name>U4LLX5_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_08532</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="1"/>
            <end position="50"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="325" mass="36988" checksum="043DF993AF74A6E3" modified="2013-12-11" version="1">MIGRRISHPAPASPEPLSRFLSEDQKTSPTPYARHQIDYNENSTERPGHGFGDPFAGNHFPYDNFTTNPTFEAEYLRDSEYLLTSKERWDDQYGYGGQQMGVPWGYVRTERVGYNRVLASLRDLTRGLGSDGDESNGRSRYQRSDTPICIPPIDRATSTSSVHSGSAGGYQGAGIGTRPAEPRNTAPGGTTSRQCFVYKGLKDKSKRDGHPCATLRFLDSKKLLHHLKTVHRDHYCPFCFKENRTVDKLKNLWFNNAPLMTNHNEENEELQQDRGEFRSQDYKELNEALGKMKKSKEVVARFTLPDGRMRPESMATTVRWVDTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMI6</accession>
    <name>U4LMI6_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMI6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="185" mass="20790" checksum="9DD71FB360197519" modified="2013-12-11" version="1">MLTITSQKWSHRDHRGFFKREEGITSFGFPGKKKTQLNFIFDANQDFDFKFHIKASISAFRSTHSSSITNHEVLRHHSSRLLPSPCPRGTNPEANALAEPEAFPEVYPEAIAFPEPEAEAYPEADADYDLEKRHLLSPIEQHSDTRAMYQAPFTATSQQAVFLTGPAQAMSAIVPSRVITSGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMU9</accession>
    <name>U4LMU9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13753</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LMU9"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="800"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="535"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="626"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="954"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1261"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1480" mass="165588" checksum="77C668C92A48DD1A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNQ5</accession>
    <name>U4LNQ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNQ5"/>
    <dbReference type="OrthoDB" id="5352583at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="530" mass="59533" checksum="799E605ACC390519" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP16</accession>
    <name>U4LP16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to AMSH-like protease sst2 acc. no. Q9P371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_14342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP16"/>
    <dbReference type="STRING" id="1076935.U4LP16"/>
    <dbReference type="MEROPS" id="M67.A14"/>
    <dbReference type="eggNOG" id="KOG2880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWGVFRL"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="452"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="633" mass="70554" checksum="6D9BBDF8F067C0FD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP34</accession>
    <name>U4LP34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SH3 domain-containing protein PJ696.02 acc. no. Q9URW6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP34"/>
    <dbReference type="STRING" id="1076935.U4LP34"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SNCKARN"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="389" mass="40403" checksum="B0D50F82E34AD4B3" modified="2013-12-11" version="1">MGLNNPLPSNLESECRKCARILTAFVDSRQFGPDKIIPPQVLASAKGLAIITVVKVGFVGSVRTGSGLVIARCPDGAWSAPSAITINGAGLGGQLGVELTDFVMILNDTAAVKTFAQPGGITLGGNVSVAAGPVGRNAEASGAASLKSVAGIFSYSKTKGAFAGVSLEGSVIWERKDANKRFYGSAVSASQLLSGSVQAPQAAQPLITILSSRIFSGNRGGMGGDYVIQDSGYPRGQDDHAARRQSEIPRGFQRDDDFATQGRARASTWTESPAASGGYDSFGRFSSGNYESAPASPSSPLSPRGSKGPAPGRPTAPKPVFKPAVPKPTLQKNQAIALYTFAAAQEGDLGFKKGDVITITKRSDSKNDWWTGTLNGEVGIFPSNYVETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPF3</accession>
    <name>U4LPF3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_01167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936097">
        <property type="protein sequence ID" value="CCX33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPF3"/>
    <dbReference type="STRING" id="1076935.U4LPF3"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="598"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="703"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="820"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="846" mass="94275" checksum="7DC378B54B556366" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPF4</accession>
    <name>U4LPF4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPF4"/>
    <dbReference type="OMA" id="HPVYNFY"/>
    <dbReference type="OrthoDB" id="5431113at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652524" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1103" mass="119988" checksum="14BF3B6B47559144" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPH0</accession>
    <name>U4LPH0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_02067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPH0"/>
    <dbReference type="STRING" id="1076935.U4LPH0"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000008">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="10127" checksum="ACEE71EEC490959E" modified="2013-12-11" version="1">MDALSPNEQRDFQNIVERRQMKDFMTMYSNLVQRCFDDCINDFTSKAVSVKEETCVTKCVDKFLKTSERLGQRFAEQNQAMAQGAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPS0</accession>
    <name>U4LPS0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative helicase mug81 acc. no. O60072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LPS0"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="287"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="491"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1103"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1858"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1861"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1898"/>
            <end position="1910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1998" mass="224333" checksum="FADE0AB8282E6C2D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQH3</accession>
    <name>U4LQH3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQH3"/>
    <dbReference type="eggNOG" id="ENOG502S1U0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAKDWAY"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="295" mass="33309" checksum="DEAC31A9679444E2" modified="2013-12-11" version="1">MADFTSIWSPAKVFSPTVARQQSQQLREWQYIDNFLTSKFHPNPVPPFERNADTLKALMALASANESADESRSLEIRVKEKALDELKKREAAEEEKRRGKGEPLLVGVEENLTSDGRRCLNSVALLSVALGSGGVGEGRIANHLLDLSIQETSLSLQSTRIEALHTRLLGELSSLREILRDLNTNPVHTLPPDINNRITEWSRTTRHLSNKMEDYKERLQTVEQKPGLTVPELIEKEKEVLTLKELVLDLEGQAKGFQGLPPEKDLARVEVERVQAELEELERVREGLYDTMVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQH5</accession>
    <name>U4LQH5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQH5"/>
    <dbReference type="STRING" id="1076935.U4LQH5"/>
    <dbReference type="eggNOG" id="ENOG502S0DI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KVVFRWK"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="453" mass="50850" checksum="FCC846AEF8C7459A" modified="2013-12-11" version="1">MPLDENFPTYYFHPLSPTETAIKFTISGSPPQQDYTLLRGDVANTYSLSLHDAHFPTILYATLSSTVSLTPESPPRIVLPKEFTINLHSPDHSITFTRHASILGDSWEFTLPCHCFPQPTNSALDTVYAPPVLDILKFRIKKEGGIISRPQLCCVLAGEGNEPDTVLGMYSLGKNEMVVYESNFRRVELEDRKGLEILMVLGCRVVSEVYGNDTMRVFNVPQQEGKRRPSAGRATTGTPAPIVGQQPVPVNQAPMAPTSAPLQQQRRQLSFKEEEARRKKAAEEEAKKIAAEQAAIREMLRREQEAEQQRIAAETERLRREEARRLEMQRRQSVPQARHPQQQHYPPQPPRPGVFQQSQSHQRIPQMPAPPNQQPRRLQSQQVLRQSVPGASSRGSQSAVGLTPQGQGQKKVDRRKSFLGLFSSGDGVKEEPSKKPQKPQKPQTNGKLVKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR41</accession>
    <name>U4LR41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Kinesin light chain acc. no. P46824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936597">
        <property type="protein sequence ID" value="CCX34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR41"/>
    <dbReference type="STRING" id="1076935.U4LR41"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASTYMKQ"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="15037" checksum="4D70A742CCE66089" modified="2013-12-11" version="1">MNNLALMLWNQGRWVEAEKLQKKVLETSKVILGEDHPDTLTVMNNLALTLRDQGRGDEAEKLQKKVLETSKVILGEDHPGTLTAMGNLALTLRDQGRWVQAEKLQRNYAQPTAERNNEVDGVGPFSGSKRKDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRI7</accession>
    <name>U4LRI7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to AT hook motif protein [Neosartorya fischeri NRRL 181] acc. no. XP_001265419</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRI7"/>
    <dbReference type="OrthoDB" id="5418867at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="223" mass="24309" checksum="A46007B39BF239FE" modified="2013-12-11" version="1">MPFHWSPSADALMLAQIIRIHNIKLKYSEIASSMSPELTGNAIRCRIKGLRKAGRESDGAGVGGDINFNSSFLRDAGENGGGGVESDLNGDKDEGEWHGFDQQTAPPEAPGSAPSLSPSTKKTGMKVNKSSLPKPKPRNKRNSKWKKAASEKKKLSEILEEQHAAYVPPALKKIELELHNGSENKDSSEYETGEETESEISVGENEMGVMAMIEKMEDPIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS08</accession>
    <name>U4LS08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936516">
        <property type="protein sequence ID" value="CCX34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1577640at2759"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
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    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="270392at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0000428">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RPC1"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_5"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="555"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX31916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1453" mass="162132" checksum="D58166FFC618A34A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVN9</accession>
    <name>U4LVN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to L-fucose-proton symporter acc. no. P11551</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">PCON_04234</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="MFS_TsgA-like"/>
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        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="115"/>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="182"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="214"/>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
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    <feature type="transmembrane region" description="Helical" evidence="3">
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="388"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="419"/>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
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            <begin position="30"/>
            <end position="425"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="454" mass="49422" checksum="82297B3E695B1C36" modified="2013-12-11" version="1">MGFFKKRSLRARDDQVTNASELTLRQSLKPMGLVIILFFLWGFAYGLLDVLNKHFQVTLDISRARSSGLQAAYFGAYPIASLTYARWVLKNYGYKATFMLGLTLYGVGALLFWPAATKRSFGGFCGATFIIGSGLGTLESACNPYLAVCGPPKYSEMRLNFAQAIQAIGTVVGPILAAQVFFKNVDDRDLTSVQWVYLGIAIFVFFLAGVFFLSDIPEVTDADMARQAQDSGVFEEKPLKKQWLLWIAALSQFCYVGAQVAVAGYFVNYATEVQPGTSNAMGSNFLAAAQGCFAIGRFGGTLLMKFFKPRKVFIGFFTGVIGFCAAAMAARGYAGIAMLMTVHFFESICFPTIFTLGIRGLGRHTKTGSTVIVGAIVGGAVVPPLLGFTADKLHDTGKAMFVPLIFFGVGYLFPVLVNFHRPTAKLMDGFLESRVGVEEEGGVKKEVEEVEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWB8</accession>
    <name>U4LWB8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWB8"/>
    <dbReference type="OrthoDB" id="10467089at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652459" evidence="2">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="230" mass="22182" checksum="B45B874DC6295D90" modified="2013-12-11" version="1">MRFFALLPILAALASATATGAQEPVASGDASVKASADTSVSSGSSSSSSSGSSSDSLSSSTSSDKSASGSGSSSSLDNLAAIGQYESMPGVSALMAAYSKYTTASGFSAFQSGMMDVALGYAATGITAFPSATDPAVLATDPAMLSLVSGIQGAVSKYVATQTYLASDVKSSLAADLSKAAKSANLVGPTKTGSAGPSGTGIEVQETGAANKVMGMGAAIAAGVVGVMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUK0</accession>
    <name>U4KUK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YHR097C acc. no. P38809</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUK0"/>
    <dbReference type="STRING" id="1076935.U4KUK0"/>
    <dbReference type="eggNOG" id="ENOG502S21G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPSMIHH"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="509" mass="55165" checksum="4ED4940481FD4F15" modified="2013-12-11" version="1">MSLAQPPAQERRPSPSNLELGTNNPFRARLSGVPSPTTTDHYFGSQGPSRERPKSRNPFLDVFDDESNGDFGFDNSQQGIHRANSFDATNGQRNQLTGSAAELFENLTIADNKPAPPASMNRPPPPRPPPQGSHHHKSRSVLDDAPLISINSFPVEGSRPPPPGARRPPPPNGRGPLPPSGGDRSRGAPRPRPRRNSDSSVIDAHENEARDRSRRERERGERSHRDKDGKLRPDAGSKSRREPSSDRRKKNSALDVIDKLDVTGIYGSGLFHHDGPFDACNPHRNKNSRRLAPVQAFPADSANNSMTGFGPLNEKADHSHIFGNRGDEAYHDYTASARPTGKRAASFDPKSAVETLHGDESLGLGTSTFLDGAPASRAAIAKNIEFEERPRSGSEGAMSGGGLQRKKSLAQKIRSIKPSGEGRRRAPPPPPGAQRSPPEGRSPTTPQDSRDGYFGNDYDDAYDKKGENIARNAPSSPKHPGVVRAGTDDGQGSGLLKRVRSLSKPKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUV7</accession>
    <name>U4KUV7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_02773</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUV7"/>
    <dbReference type="STRING" id="1076935.U4KUV7"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWKEEGD"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX04591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="34071" checksum="37B15E08BB373078" modified="2013-12-11" version="1">MTQLANLHEDMIHDCQLDYYGKRLATCSSDKTIKIFEVDRENHRLLETLRGHDGPVWEVSWAHPKFGNILASASYDGKALIWQERQGQWSKMVDGSARPVEIQHTASVNSVKWGPHELGAVLACASSDGKVSVLEVREDRSVVTKAFDAHKLGCNSVSWAPVTTPGSLVTTTLSGASTGPLPQRRLVTGGSDNVVRIWLYNNDTGEYTVQAELLGHSDWVRDVAWAPSVLPRSYIASASQDKSVIIWIAESPEGPWVKKELPMESVMWKVSWSLSGNVLVASGGDNKVTMWKENSHTGEWFKVSSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV58</accession>
    <name>U4KV58_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV58"/>
    <dbReference type="STRING" id="1076935.U4KV58"/>
    <dbReference type="eggNOG" id="ENOG502STXW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32125" checksum="4568E94BA1C0FB88" modified="2013-12-11" version="1">MFGPESIYKEASDLRRSQVFGNPTVVVLDDDSWALEVVLYALHHQNDLLPHRVEVEEMVMIAAICEKYELAQALRPVADRLFRGLRRETGKQGNENLLFVCQVFGYEEEFEEVSREMVMRATYEPGKGVRFGEAGNERGPRWVGKQIIEKILDVRKSHLEALRSYAKSLHTDPAHQLEIPLRSCLQGGVYKDNCEALQLGHLMKIVSKHNLDDEEMWNQSLYAISTQLLNIKNLYLPKNSACAEDHSGCSWVPGLHNAVQRVLESVKGLRLTNWPVRREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV96</accession>
    <name>U4KV96_PYROM</name>
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        <submittedName>
            <fullName evidence="14">Similar to RNA polymerase I-specific transcription initiation factor rrn7 acc. no. Q9UST5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04744</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX05157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV96"/>
    <dbReference type="STRING" id="1076935.U4KV96"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IAEMFPI"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="12">
        <location>
            <begin position="82"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="13">
        <location>
            <begin position="247"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX05157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="626" mass="71458" checksum="C27CB047D5B392BF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVN0</accession>
    <name>U4KVN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Rik1-associated factor 2 acc. no. O74560</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935225">
        <property type="protein sequence ID" value="CCX05001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVN0"/>
    <dbReference type="STRING" id="1076935.U4KVN0"/>
    <dbReference type="eggNOG" id="ENOG502SK9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="560" mass="62844" checksum="FF7910FB3B5DEBEF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW76</accession>
    <name>U4KW76_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935277">
        <property type="protein sequence ID" value="CCX05938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="372" mass="41530" checksum="67BBED527FF8A760" modified="2013-12-11" version="1">MKLQGKSLKHTQKFDPSEEIPSSPLFGLPTLTIEAKPNPMCSHRPLKSPPTPFNKMPSKGYVSDGDADTGSEKESIKPKGVLRTPKKQHNYRWNPYNNDYKMALSYVVSPNNRAPKAPWGKIYELPTSSDEVTRAETQADITNTKGSNYCSEGNKIETVNLTTNNPPSPKVKVETIDLTENEPSTPTKSIKHEGHDLVDPDETELEESDSDSGRPNIAASPPYYGTPENGYNKATSTPPTTPHPIKTPRKTFDLNLYDPDETELEESDTESEHTSSPSKKLSPRKETATPIVDPDETEEEDQSDAESDDTVVAYLVSKGLLPKRDQEPIVDPDETEEDSDLTQDEEEQLILQTAYHLEDLEHYSFLADSTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW97</accession>
    <name>U4KW97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to L-idonate 5-dehydrogenase acc. no. Q1PSI9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW97"/>
    <dbReference type="STRING" id="1076935.U4KW97"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INHPARW"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="190"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX05717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="40490" checksum="0F7520B164196F9E" modified="2013-12-11" version="1">MDRSTVKAAVLLGAKSLEIQSVELSLPLPGELQIEIRSTTLCGSDLHYYNHYRNGDIIVKSPLALGHESSGIVKLVGSEAAAEGWKVGDRVALEVGIPCGNCARCLEGRYNICPTIRFRSSAKSNPHYWGTLQERINHPAKWCHRLPDSISYSQAALLEPLSVALHATRRTERNGSLYPGANVLVIGAGAVGLLVAAVTNLTGTSKVCITDIILERVDFAIANGWATKGYVAPPGLTTGLEIATDLKAKLNMLNGYDVVYDCTGMEVCVQTGIYAARSGGALMLIGMGSPVMTLPISAAALREVDILGGFRYANTYQLGVELLASGKLQNVEKLVTHSFRGMEGIQTAFRTAAQRMDENGQLIVKVEIETGSDSVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWC1</accession>
    <name>U4KWC1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWC1"/>
    <dbReference type="STRING" id="1076935.U4KWC1"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="189"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX06132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="449" mass="50951" checksum="44EDECEF67AC8E8E" modified="2013-12-11" version="1">MPYNIAMVSDFFYPQPGGVESHIYQLASKLSDRGHKVIIITHQYDTRSGVRYLTNGLKVYYVPFFVIYRESTMPTVFSFFPIFRQIVIREKIQIVHGHASLSSMCHEAILHARTMGLRTCFTDHSLFGFADAASILTNKLMKFTLSDIDHVICVSHTCKENTVLRASLDPVNVSVIPNAVVAENFKPDPTAASKDHITIVVISRLFYNKGTDLLVAAIPRICEIHPTVHFLIAGNGPKAIDLQQMIEKHMLQDRVELLGPIRHEEVRDVMVRGHIYLHPSLTEAFGTVLVEAASCGLYVVCTEVGGIPEVLPSWMTVFARPEEDDVVSATCRAIAELRRGNVKTEKFHKRVQKMYSWTNVAMRTERVYDNISNAERGTLMDRLKRYYGCGVWAGKLFVICAAIDYLLWWLLEIWYPRTSIDEARDWPKKEVVVKDCKEGSGIRVGRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWR6</accession>
    <name>U4KWR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWR6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9566" checksum="6C8DF901F0FC4616" modified="2013-12-11" version="1">MVEMSPRRANLRHPRHATAASRDEYAQGPPTRPRCNRACTTIHDPSVGNHTNCQLHFGPRRECFSLPKSSIHTGYCNVPQEVSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXC2</accession>
    <name>U4KXC2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Protein transport protein Sec61 subunit beta acc. no. Q9HFC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935278">
        <property type="protein sequence ID" value="CCX05991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXC2"/>
    <dbReference type="STRING" id="1076935.U4KXC2"/>
    <dbReference type="eggNOG" id="KOG3457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSGMWRF"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX05991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="11591" checksum="1ED61F5EAF91E6C6" modified="2013-12-11" version="1">MSGSPRSDSPAGASGSEGARTSGARPTSPSAPGGPKSAIRRRAAQDRAQKIANTRPSSTRAAGAGGSSSTMLKLYTDESPGLKVDPVIVLGLSLGFIFSVVALHVIAKIGRKFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYH5</accession>
    <name>U4KYH5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYH5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="167" mass="19096" checksum="EC0D2413E7BA972D" modified="2013-12-11" version="1">MRHAMQEAFDKKRRECVTILKSTCSDSIRPYVSRVGGPIEIWATWNANLVDGEPFEDYFAKLIDIRNQLHGTPDAITDAQFKAQIMRSMPPWMSVTVQFVYQKPEITPGEVMYHICNMAASLRAVEKPAAEAEALATESRKSTNGRKWCNNCKDKSLNFSDIADWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ25</accession>
    <name>U4KZ25_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ25"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8512" checksum="0712BDFF3DE2410A" modified="2013-12-11" version="1">MGRHHASATTVVDAATIKALYAPLIRALMTAMRETYQQISAQNSWAPGQMFPLLHHPVLKRKNHSQMFEEGRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ28</accession>
    <name>U4KZ28_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935328">
        <property type="protein sequence ID" value="CCX06950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ28"/>
    <dbReference type="STRING" id="1076935.U4KZ28"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLLHPPH"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="342" mass="38502" checksum="B8E6288007284558" modified="2013-12-11" version="1">MAANYWTSSQRKHWTMTREKLAETRQNLDMADEKALATFPLPSYRHLSIFFHLQLVRLGRRMTARQQALATAQMYVRRFYTKVPIRDTNPFLVMATCLYLALKMEECPQHIRIVVSEARTCWPEAMPSFTEKLAECEFWVISELNSYLIVHHPYRTLQELSTPLALTTEENNTSWQIINDSCITDLPLIYPPHVISLTAIFLAVFMKPSPSGNNSNNHGAHGANMGNHSSHNSHNGHSSGHSSMASHNTLGGSSHGAGAALSSYAAGSGSQTSRMAKLIEWYAESKVDMEAIIDCVQEIMALYEVWEGFGMQQEKALKDIFVKMVKNPQPSQPQQQLLQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZA6</accession>
    <name>U4KZA6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZA6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="13847" checksum="BADE1CBF7E0DC5AA" modified="2013-12-11" version="1">MQNRSWRGQFQVQIYAMTLGRNRTRTSGMSMRDIDDNERRRRYERWKRLGLRREKCNYSSRAQCRIENSNVPCQGCRGNLGVCLNSFLGNKQPRRHPKYDGHFCAHFDMGSACLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZE1</accession>
    <name>U4KZE1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZE1"/>
    <dbReference type="STRING" id="1076935.U4KZE1"/>
    <dbReference type="eggNOG" id="ENOG502RYK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWAEWIR"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="87"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="588" mass="64966" checksum="E992C8962C3C91DA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L002</accession>
    <name>U4L002_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L002"/>
    <dbReference type="OrthoDB" id="5284640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="11354" checksum="01681DBA096FB5E6" modified="2013-12-11" version="1">MQNSSYRIVIVYDAQEHTLLAHKWKCGKDNTPGFRRASEQLPRWRNQFDVYICGNGGQLDNNRPCSDFIATVKLNTLPFLVDLRRHLGQIKDIYVKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0K7</accession>
    <name>U4L0K7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07876</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0K7"/>
    <dbReference type="STRING" id="1076935.U4L0K7"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="389" mass="43604" checksum="0E9334E61646897F" modified="2013-12-11" version="1">MALNSFFNNKIEAMKLEIIERNSKLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMGSKRVLVKVHPEGKYVVDVAEGVEVSTLTPGKRVTLISDTYRLERILPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPTVEARADILRIHSRSMNLTRGIDLKKIAEKMNGCSGAELKGVCTEAGMYALRERRIHVMQEDFDLATAKVLNKHDDKEMSLSKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L124</accession>
    <name>U4L124_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935465">
        <property type="protein sequence ID" value="CCX09438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L124"/>
    <dbReference type="OMA" id="PRRIMNG"/>
    <dbReference type="OrthoDB" id="5353066at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="905" mass="98793" checksum="936333C3E05012FC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1I9</accession>
    <name>U4L1I9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1I9"/>
    <dbReference type="STRING" id="1076935.U4L1I9"/>
    <dbReference type="eggNOG" id="ENOG502S4RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEASKCH"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="809" mass="91054" checksum="0B34B8CCDB1A214B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1L4</accession>
    <name>U4L1L4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_09360</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1L4"/>
    <dbReference type="STRING" id="1076935.U4L1L4"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="18">
        <location>
            <begin position="98"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="17">
        <location>
            <begin position="412"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="19">
        <location>
            <begin position="641"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX09767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="709" mass="79155" checksum="F72D14907576A991" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L271</accession>
    <name>U4L271_PYROM</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_05955</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935286">
        <property type="protein sequence ID" value="CCX06368.1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="52" mass="6075" checksum="B04ED0E6E480DE13" modified="2013-12-11" version="1">MWRLAPWVVFCKKLSCRIICSLRSYSAVRAVVMCGWPLSWIPLYEDEANVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3A7</accession>
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        <submittedName>
            <fullName evidence="5">Similar to Neurofibromin acc. no. P97526</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">PCON_02606</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1201"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2569" mass="288399" checksum="2459625E115AB149" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3M4</accession>
    <name>U4L3M4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to LINE-1 reverse transcriptase homolog acc. no. P08548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L3M4"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="33476" checksum="8CD8D969C4B48FAA" modified="2013-12-11" version="1">MPGKSYFDHVKHAQLLIDYARLKDKHLYLVLLDQEKAYDRIDHGFLWKTLEQFGVPIDIIRAIQGCYSQAKSVVSINKFTSETFDVKSGVRQGDPLPCLLFNAVIETLALRIIEEPRLGGFLDENDIRHILDLYADDMAVTLTDLNQMKALLHVYKIYAKASGSTLNIQKTEIIGALDSTHAMEYRGIKVYWLGFFVVRLIELYYDQLQCPGCEFLNWDTSMSNVTKIEPPVPDVTLDGSPSTEAQFKAFKEKLKALGLEGQDFHGHDHIGIRERCQQHWDQNHGRLRSAVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L411</accession>
    <name>U4L411_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03777</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L411"/>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="44712" checksum="42114E7234193CF5" modified="2013-12-11" version="1">MSCGKPLADFIEMQIRKQIELFMVWDKLQVNSDGVLPQNLLDTYPDEIWTTYMAHYMRKVHSYIGRVMLLHSKYQDDPRLGIHVQLTTYAMVWKNFFPCDDHYDNPVSERSEGWFDEAMAVLPQLASEIEEIVLPVDPQSTGGYKQPWTKILGPNTVLRTNPPRAEFDRFPGLAPVANLQFLPVFSKSRIKAWNKDLATRHQQVCSSIRKKYKGYTGVKAPAVVHYGATNEAAYFANDDAKDIPGWKTRYTGNAQKFAHLTGYMSMVMNYSTRVTQMWGWYPNHPELEGHVNLAACASMWDCLENESVEDEKQWVDLTFKELDALLDDICDMLFQSGPTAENWRDILREQQKNYWSVLTKERDHFLRRRSYFEVWHKANAPVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L466</accession>
    <name>U4L466_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Next to BRCA1 gene 1 protein acc. no. Q5RC94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L466"/>
    <dbReference type="STRING" id="1076935.U4L466"/>
    <dbReference type="eggNOG" id="KOG4351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKHGHHP"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="426"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="847" mass="93139" checksum="163B7989866E1893" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4P2</accession>
    <name>U4L4P2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HF935347">
        <property type="protein sequence ID" value="CCX07273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4P2"/>
    <dbReference type="STRING" id="1076935.U4L4P2"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVDWWLE"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="457" mass="51462" checksum="4BBBFC963434D3D0" modified="2013-12-11" version="1">MTTTNDEFEQRNANFMQWLVSSQHAEVNPKCALTDLRSIGGGRGVVALSPMEEDELVFRIPRASALTLETSNLKTLLPEAEVAALDPWLVLILVLIFETRPSSPWAPYLDLLPTDFNSLMYWSGEELSQLRGSAVLDKIGKADADDIFLNKLLPVVQRNESAFTETCLRNVPTGMGFDEHFLITAHRMGSIIMSYSFDLEVVHENKPAKEEEEEEDSDDDEEEKEHYKAMVPLADMLNADADRNNCRLFETATMLEMKTIAPIEAGAELFNDYGPLPRSDLLRRYGYVTSNYAQYDVVEISAPLLVQVAGAGLGAEDRQARIDVLLEEGVLDDSFDLDRSLEIPEEIIVTVRTLLLSKLEYKKFQEKGKLPKPMMEPAVAKVLREVVDKRLKEYPTTLREDQKLLEGEMRGRWRIATEVRMGEKEILVAVKESLKTVATNKRSADAEETKGGKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L519</accession>
    <name>U4L519_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to DNA repair protein RAD51 homolog 2 acc. no. O35719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935634">
        <property type="protein sequence ID" value="CCX11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L519"/>
    <dbReference type="STRING" id="1076935.U4L519"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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    </evidence>
    <sequence length="36" mass="4274" checksum="CA28513A08B69644" modified="2013-12-11" version="1">MEQPPLDNPNLEHLCMSPFRTTVIRPLVPRHRCFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5G8</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
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        </source>
    </reference>
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        <location>
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    </feature>
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            <end position="163"/>
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            <begin position="1"/>
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            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="333" mass="36612" checksum="D30CB2216A32FE35" modified="2013-12-11" version="1">MYFDPSPPQSPMSGTHRSRRGSCSTKSSKSKSSSKSHRSCHSSRSSRSNTPDVIAQALQNTLFLHPASSPSIITSRDASGNSRTIIISSSGRILFQQPGTSSESYAELLAATERGVHDRLLNLDGASSEDPAKPVLKQIKEEKEDLQEKVEEIRRSVDLARLQRENEQLLSQLAAQRAPMQLTLPERKIKTTKPSISQPEHRANIGGLPKSRAQMSRNKPILAAPAWTIASPKPTRPKTPGSMLGARRWGEECEDVKAWLKALSDGGEDEFESVSSAAELAQERRKSLMKAVEITEREEAKVEVKEVKAITPPLTPPPVVNQLPRSRAFRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <name evidence="10" type="ORF">PCON_04922</name>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX05335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L5K9"/>
    <dbReference type="eggNOG" id="KOG4086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="446"/>
        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="446" mass="47482" checksum="043E0B663BFBB96B" modified="2013-12-11" version="1">MAAAQQPPTIPVAAPGRTRLEIELEFVQCLANPFYLCHLAQTKVLEDERFMNYVTYLNYWREPVYARMLSYPIYTLNALTLLAEPRFRIDIANAGVAYEMLSQMVQTFLPIPGGPTSLDLPGPTGADLPNPIDPNNPSTAADAAVAAAALGGALGNAPSAASGAVSAGASTTASATISARASANASATASGTASARASAPASKPSSSAPVPSSSRKAKLGELLIGIEDEPSGPSGPSPGLPGLPVKEEEDPEAVKAEMEQRKAKEEEDPGVVKAEMERKKAAKGLRWRENKKKRKEEEKKQKKKERNKKWKERQKRAREERRMAKEKKEVHSMEDQVAYHEDEIDDVYEEYEKLKAKEAGETADHKGKGKAIDRGGDEIQEQEEKEEEWSNPSTAAAVLAGGSGLGGNASATTSARALANAASKSSSSTPGPASKKAKINEANGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L638</accession>
    <name>U4L638_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
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    </feature>
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            <end position="40"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        </source>
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            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
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            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
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            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="16944" checksum="070721C174C2A604" modified="2013-12-11" version="1">MVQPRRRSSPPEDPFADPPAVPDRSVVSQHHQPRSSFSSAGHSDSGDRDYGDHDYHARARLVENTAALVSVSSPYSGDKGKHKWDDPRHTHRLGSRAIASCSSAAKNLRGHASSLTAALKPTSSATKAIAASETAARQRDAERKLEAQKQEDKLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="44" mass="5022" checksum="C94C7E9C91B54397" modified="2013-12-11" version="1">MKPPAIAFAFNLLRSSTCQASCIHPERRYPSTRVFLLTRNLADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6U1</accession>
    <name>U4L6U1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Chromatin-remodeling complex subunit ies6 acc. no. Q9UTE8</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="16746" checksum="16F71AD75CE0E6E7" modified="2013-12-11" version="1">MSTPSSKKSKAVPPVTPTTGPNPLLELLDITPHPKGFKNPDYKPTARRNKNLKQMLSDAAAASKPSAAVPTSGPTSAPAAPTAPANEMQTTYANIESAPSFKRGNRWCDITGLPAKYTDPKTKLRYRDGEVYKVVRSLAPGGPEMYLGVRGANVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7A4</accession>
    <name>U4L7A4_PYROM</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="3 4">
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935275">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7A4"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="582" mass="66411" checksum="73472C3CC9A5E7CD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7S8</accession>
    <name>U4L7S8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ABC transporter G family member 24 acc. no. Q9MAG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935446">
        <property type="protein sequence ID" value="CCX09233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7S8"/>
    <dbReference type="STRING" id="1076935.U4L7S8"/>
    <dbReference type="eggNOG" id="KOG0061">
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="784"/>
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            <end position="469"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX09233.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="811" mass="88375" checksum="6A79588E767C61C1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8M7</accession>
    <name>U4L8M7_PYROM</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CCX15033.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="8" mass="861" checksum="F95735B338640876" modified="2013-12-11" version="1">MGRGKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Y6</accession>
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        <submittedName>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8206" checksum="F0FF3A50B53B9BAA" modified="2013-12-11" version="1">MFLGLIGPVKFSAFKSSSFLRLFLCGVSSCFESCLLTLSMCFVFEFLPCRSSSSRSIMDAYQIPDHFSGHSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L913</accession>
    <name>U4L913_PYROM</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_06201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935302">
        <property type="protein sequence ID" value="CCX06614.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="472" mass="52235" checksum="8F7128A8507FEC57" modified="2013-12-11" version="1">MSEVANYGIPQDSTTVVTTKDLLAKNCPVCREYFGSIGGFLQHTSTSHPYYHPERLDGLRSDVMIINDTMNLLGSLEESQQSDVKLRVLLASECAYNVFTAETTEKPATQAMDLTPEQDERIYRTLVQAFQAFELRKQAMKQNVPIPIIPAENEDQHNQPTATTLLRPTIYRIEYYEPPTLDARNSALPIFERPVVPAVGISNPFHNSFTRRPTQAPPPKPQPIQHNPQGLNPMQNTLTTSTFRKIAPAPSYTRPIIPALVLPPSRPISRHIAPRQIAPRPIAPAPHPDPPNPAIPLPWTPIISRPITLPLGNRRGAAATARKRKRFQLAPRPAPQPAPNPAVPSFHVSLPKPDRVLVYNDKFGYQSMLPLTGQKTATATQSAARELQPAVQGLGFKVVPTSNESESKNSSPVISSRVRKNKSEKNGGMKANMVQSTLLKDGSLAWGLGRRKKKDFAPGQAIFRKIKQEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L916</accession>
    <name>U4L916_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935967">
        <property type="protein sequence ID" value="CCX14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L916"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="13050" checksum="45750273A8DDF805" modified="2013-12-11" version="1">MVLCNHGGLSRTTVQVQKTYRQPFYNTATIRNSTERNIHGGYMTYQVLLSRPECIESRLKCSTGGTSMTSERPGKCRYEFMIFTDQLRPCQGRHFVNICLAGLISSLRKIPRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9I9</accession>
    <name>U4L9I9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to DNA damage response protein WSS1 acc. no. P38838</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9I9"/>
    <dbReference type="STRING" id="1076935.U4L9I9"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GTLCEFY"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX06849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="452" mass="49677" checksum="C8C414B1E72CBF71" modified="2013-12-11" version="1">MAIIGTITYLHALPRPQHALFLLRRVASIVKPIMVAHGYKIITFAEMFPKEAGLLGLNYNKGVKLCIRLRPQYDPSKFLPEEDLIATMLHELTHNVYGPHDEKFYGHLRKLEDEYYALKAKGWNGEGFLGPGNMLGGRNIDAVDGLGLRGLRYQRQHAVAAMEQRLERSKGSGQRLGGGIVNNGRLSQQEIIAQAAERRQWDQKHCSGDHTFAGEVGGTSIGGLKESLEEDAWLKEQIKEIYKGWWEDENGAIVIDDDDEPKRPATTGYWNCRMCTLVNPATKSRCEVCDTARPGPPPAPISKALRKAPAKSPAKAPEKAPTKSPQNSSIWTCTLCTLNNPPSRTRCDACDSARPSLGAQQSLRPSASFSVSSSSSSRSSISKPGSSGSRSSGSSSASKSRKPSKSSSTAQMLERFNTPNSKQPDWSCHVCSTRNEHEFWSCSTCGWVKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9X9</accession>
    <name>U4L9X9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935547">
        <property type="protein sequence ID" value="CCX10534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9X9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="10193" checksum="17C7D9D37C542CE6" modified="2013-12-11" version="1">MSYTYQVLLEYGDASVLPNSTTTYESVEQANAEANRLWLRTFKRHAEYFCDWFAEPNAGARTYFWPVPCGKDDIVRAWVVRCEMWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAP2</accession>
    <name>U4LAP2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAP2"/>
    <dbReference type="STRING" id="1076935.U4LAP2"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="521"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="200"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="416"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="753"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX15414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1238" mass="141142" checksum="C04C99C040B3EA6B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB71</accession>
    <name>U4LB71_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB71"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="153" mass="17647" checksum="B2F99A2DD291F13E" modified="2013-12-11" version="1">MLQPIRRVPLRSCSLSRKPFFAPKTQYRTIKHDSSNQNAEGNETYESVKERFKRMKLYYKSLSKSEPTPDISEAREKDQQVTNSYHYTLAADQLAQLSKEMKDFRGLTTDQASKLPKKLEKVEKELTNTKTAVLELATNQLAQLSKEIEGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB91</accession>
    <name>U4LB91_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB91"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="12244" checksum="25EDEBD810065925" modified="2013-12-11" version="1">MVLLPKHLLPRKLDDSNEFVGFREIIANINKFIGTILKDYKSKLVYIKTAIKYRKDKPATAEAMERRIRDLYATIGHRVSAEKLVVRIGKPLRDDLLGVDCCVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBR8</accession>
    <name>U4LBR8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized transcriptional regulatory protein C417.09c acc. no. O94490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936498">
        <property type="protein sequence ID" value="CCX16672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBR8"/>
    <dbReference type="STRING" id="1076935.U4LBR8"/>
    <dbReference type="eggNOG" id="ENOG502RNV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HESLLHM"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="762" mass="84441" checksum="CDFB00A78BA37817" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCX5</accession>
    <name>U4LCX5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to E3 ubiquitin-protein ligase CHFR acc. no. Q96EP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936522">
        <property type="protein sequence ID" value="CCX16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCX5"/>
    <dbReference type="STRING" id="1076935.U4LCX5"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="295" mass="33534" checksum="134049F0D1BF602B" modified="2013-12-11" version="1">MSDRTTRLAASLGVQAIATSPVVSRKRQRSNTMITHNDEERISKSARTEVSHLDAAQVTMPEEMASLLTCAICFDFYLHPVHVEPCGHNYCGSCASQWFCNNHTCPTCRSNSTAIVEHPWLSKMVSVATKRFPDKKRDPAMIRECEKHYRPGDKIKIRVTRGAGLSGPYSDDEDEYYGRYLLSPCLCCGENNYGYRCPVRTPHNTMIDIFMHSEPEFVFRGHARCGYCPNIIPTGWRPYQCDSCHDISCAEMFGMDDCDGAAIRDISDPKFSARSILAHDLKYFNIIEKKNWFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDK5</accession>
    <name>U4LDK5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935721">
        <property type="protein sequence ID" value="CCX12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDK5"/>
    <dbReference type="STRING" id="1076935.U4LDK5"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11434" checksum="1185ED3E94243DE4" modified="2013-12-11" version="1">MPKERTRKATKATKKKKDPNAPKRGLSAYMFFANEQRDNVRNENPGIAFGQVGKVLGERWKALSEKQRQPYEAKAAADKKRYEEEKAAYVAAGEDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDZ1</accession>
    <name>U4LDZ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized protein MJ1656 acc. no. Q59050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDZ1"/>
    <dbReference type="STRING" id="1076935.U4LDZ1"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNKIVAP"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="288" mass="31080" checksum="BD9E34B6E2FB2BB5" modified="2013-12-11" version="1">MSFQRLIRFLSRDGKIYNGDAILPSGTTDLSKTKLARVITGDIFGAHTVTEQVVSVEHLLTPLPQEAVRTVRCLGLNYANHAKESGMPIPKSPVLFYKPPTALAPPNADISIPKVAQSAGLDYEVELIIVIGKPCRDITPAEAPSYILGYSVGNDVSHRPLQLSPGQWSLGKGFDTWAPWGPGIVSSSLIQNPQKLAIKCRVNGELRQNSNTADMIFKVYETISILSQGTTLLPGDIVFTGTPEGVAMGGKKGSEPWLKDGDDVEVELEGVGICRNKVVFENVAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEA4</accession>
    <name>U4LEA4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to lectin, partial [Colletotrichum higginsianum] acc. no. CCF41523</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEA4"/>
    <dbReference type="STRING" id="1076935.U4LEA4"/>
    <dbReference type="OMA" id="ANCLAEY"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47849">
        <property type="entry name" value="CHITIN-BINDING LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47849:SF8">
        <property type="entry name" value="LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651923" evidence="4">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX13090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="13382" checksum="30B77E64365BD6FA" modified="2013-12-11" version="1">MRSTLMITAVVGLFMGSVWSQSQTPDGSCGGINKFLCNNPAFGSCCSSSGYCGTGMDYCGQGCQATFSNSTTSCMTKPPSSNGNCGGAENITCSGGPYDGSCCSKYGFCGKTASFCSTLGGCQAEFGAACTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF66</accession>
    <name>U4LF66_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_09725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF66"/>
    <dbReference type="STRING" id="1076935.U4LF66"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMQDHLD"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="241" mass="27899" checksum="4831A7CF17E7B45C" modified="2013-12-11" version="1">MAANEEASSAWPNPPYFYTHFTEENLSALRAHRQLLNLGTNDPIPKESLPRDSPLQFLIPPPPATGDWWSFTEQWSVEERNVDLEYAGIETLYDQEVEEPSGAQRLVELRRLSKSLLLNFLELCGLMSLNPQLFGVKLKAIEVILFNMHHLINQYRPHQARETLCMMMEEQLQKVRKETEDNREATRKVNEALVKASAIAQQVREEEMREPAESERDKEVVEKEKAKKRDAQGWKLIAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFH0</accession>
    <name>U4LFH0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="13" type="ORF">PCON_08975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFH0"/>
    <dbReference type="STRING" id="1076935.U4LFH0"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPNYFAK"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX30638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="311" mass="34764" checksum="6E2F79D1B1A69512" modified="2013-12-11" version="1">MDSAMPDASPSGSPVAKKLKLASAPTIEAPAVGPTTTTVAVPNASSGIRTGEKAQYREARKGKAELPKKKYYRQRAHANPFSDHNLDYPVHPEAQDWSVHYPAYFPAAEGSTQAKVEVADIGCGFGGLLVALAPKLPNTLMLGLEIRTQVTEYVSERISALRLQATEQKEGEEKMHHYNNISVLRANAMKFAPNLFERGQLSKMFLCFPDPHFKARKHKARIVSPGLCAEYAYILRPGGIAYTITDVEDLHNWMTHHFSEHPLFERLTEEELEGDVGVETMLDETEEGKKVTRNKGSKWISCFRRKEDPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFK7</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <end position="339"/>
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        </location>
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            <end position="124"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX30884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="444" mass="49017" checksum="0BA8EEE6C89537F5" modified="2013-12-11" version="1">MSDPISPPHSPPHSPSSPLSYPTDSPHHPDDLSEQDSQRLPSITRSTYSISDDFESDLLSEDNFDTYRNVGDESREEAGSTEDFPEATAQSEDHDSQWESEGPAAPKSRKKGLAAAAQKLPKALRPTSSGKLHPRAQYLGSRASSASYNETVQGEKKSAPLVLLHITLLFLPGAEEAVLRKITPTMLERGLLIEHPRNDYQALEELIIDALGLDDALTPAEQSEEEEEEKDEWEQSLGVRKVAAKRQWEIRVYAANGLMTSGAWKRVWNEMERVDVEVGPKGWRGKKTDELVKAFMRKDAKQRGVRLPAWDVEPLDVGFWATVVGILLLVVAAATGLWWTSPQWQEFSMPDFKAMIPWAGSAVQMENMDGVMVPEGQGHCEVVEGQDEPVCGEAIVPVNIDGEANNGKISDGSDGTSEPELLSFDEAAETGSDRWWSWKSGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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    <name>U4LFW7_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
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    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5382672at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="172"/>
            <end position="362"/>
        </location>
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            <end position="571"/>
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            <end position="841"/>
        </location>
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        <location>
            <begin position="52"/>
            <end position="64"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
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        </location>
    </feature>
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            <end position="205"/>
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    </feature>
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        <location>
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            <begin position="812"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX14337.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="96214" checksum="B626A05D98B504E8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGP6</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19312" checksum="1CE0884BD127AF8B" modified="2013-12-11" version="1">MYYFGKGSIIGGLKVVTGSDRKHMANRRELKCGKSCKMTLIKQSDKECPGFAIRGYRRTAPQPCLAWNWAERNTIIKRTNPDEFDGELFIDIAAERRRHMLSNHGRNHAGSPTAWLRLTAAGQRPGDPAATRHVSWAMGPARRDADTHEPLMDVDDVATSLDVFGSSQENSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHC0</accession>
    <name>U4LHC0_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="22757" checksum="52A00EB9EB593F0A" modified="2013-12-11" version="1">MAETVLPTSIPGDDPEDDPRDNLKDASTVDAKEKPEDDSTPEQSSGEDFEEPALEPNAVQETLEALELPTGDEKPEEDNPIQAEPVALVDNLLEGLEGLTDSGSYTQEILDTDLESKAVQEILEGLELPTGDEQAEENNPTLAESEALVDNLLEGPEGLADSGSHTEQILDTDLESKAVQKILEGLELPTGEEQAKEDNPTQAESKALVDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHC5</accession>
    <name>U4LHC5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G protein-coupled receptor GPR1/2/3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PCON_11056</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LHC5"/>
    <dbReference type="eggNOG" id="ENOG502RYZC">
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    <dbReference type="OMA" id="GFWLQIG"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="6">
        <location>
            <begin position="227"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="388" mass="42692" checksum="FE3D7873B300B619" modified="2013-12-11" version="1">MAEEYYPYPKSLDPIPSHLRAGLAVIATFGILSLITSGGAITFIVYRLTNKKKYQAIPLRYNQPLILILNLLIADFQQALSFIISIVWLKKNAILAPTDACAAQGWLVQVGDVSSGLFSLGIACQTFYVLVLRRSVPYKMFVSSTIALWVFCLSLSLISPILHHRDELFVSAGAWCWISDKYKDERLLVHYIWIFICEFGTLALYAVIFMVLTRNGVLNNAAGVQARTIQRIARLMLVYPLAYTCLTLPLAAFRMATQSGKQPNDKFLLLAGACMASCGWVDVLLYLVTRRTIVYQHSIQTTSQAITGGVGGIQMNPALPYGNNTVIGGGGGMTMHSGNHDSPSVSSSQENFVKLEQVVQVTVERATPGEQAAVEAAQKQLRGNPTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI70</accession>
    <name>U4LI70_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein AN12072 acc. no. P0CY38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI70"/>
    <dbReference type="eggNOG" id="ENOG502SBZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="362" mass="39317" checksum="F2E49B83B610C3A8" modified="2013-12-11" version="1">MSASPPSTLRSRRRAGESISSAQTLPKPEETPITFTTGEQTSSWKSTITSFLSGEALVQQQPKPQAKLKAPSMTSSTRGMKSYASSLASLASSIVSTESEEYTTNASKATPSSHRPATPPPSPPAQEQQKTLVYIHPVTPSTTLEGVVIAYDTIASAVLRTNSLWAGDAVQSRRELMIPVDSCQVRGKPVTEEGETKLQGEEEPKEENEARRWKFHSKTILPGNLGVTTVGVLLPRRAKRRKQAPAEDEMDGIGVSSVIHEGDAGRPRWMTPGVHSFHPEEERELELPSFEWGELARGAGARAGAVEGWMRRFGEGFWTTVDGAGELIEMVSDLKIKGDGDSPRSSTTNGAPRRRVARDRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIF3</accession>
    <name>U4LIF3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIF3"/>
    <dbReference type="STRING" id="1076935.U4LIF3"/>
    <dbReference type="eggNOG" id="ENOG502S1Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSWIVQS"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="513" mass="55672" checksum="8F25824CF378A1EE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIH1</accession>
    <name>U4LIH1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIH1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="11302" checksum="B309FDC20250D9A8" modified="2013-12-11" version="1">MRFFHCEATAGCRSVATTDDGCVGRQNGRDFPIAAGGSTVLYSRRCMASTVGIFQGVTKDGCFCPTARMEILPSLFENPRAISAQPCLANQTISPIGTPSRVLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJB5</accession>
    <name>U4LJB5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJB5"/>
    <dbReference type="STRING" id="1076935.U4LJB5"/>
    <dbReference type="eggNOG" id="ENOG502RNKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CSMMFPK"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="369" mass="40746" checksum="3C019380ED30F34F" modified="2013-12-11" version="1">MPALLLPDTAAPFAPRSSPTVVLPTKVDPWLTSTLKRVNRIKRSLNSVPQHLKCLTDTLSLPSAIWHLCTIMTPKAPSSQLANHSNPLTESLTTYTPLHITAYVVHVDLVLSHEVAFKLSKDTIEDLVEYHKDIYLHDQREQTWPWTEKEAAVKKLHENFVQQVNKFIYRTNANALEGLEDDGAGELLEGRAEEVKQQVLALFCPLLPPPPRVVDVVRPPAQMLPSNATGSWWSPSPVPSNAAPSPVEPWKILPSSPVEDNHHQQHSPPVSSSQPHYSHSRQDYTHQNNNSNNWMSSMMDLPSVTYSQQQNHTAATTMGASMAMGMGSMSAPLLPLPSMVAQQCGAGFGFGFGWDHQAGRGYADYAATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK00</accession>
    <name>U4LK00_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK00"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9523" checksum="8243BF7894AA9C92" modified="2013-12-11" version="1">MPPGNGKRQHHCPINGCKKVGFCDKHQTYCEYNHERFEFLTSQNCMKCELKKIHEDARKRKEKEKAAEKEAKAARRKTLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK54</accession>
    <name>U4LK54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK54"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="2967" checksum="1465DC498C420D50" modified="2013-12-11" version="1">MELLLEICGRCLFLPGCVQPWYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK67</accession>
    <name>U4LK67_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_07081</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK67"/>
    <dbReference type="STRING" id="1076935.U4LK67"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="16">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="17">
        <location>
            <begin position="285"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="349"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX29755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="475" mass="55900" checksum="BF683F05B6B69BDB" modified="2013-12-11" version="1">MAYNSRQSNVFQMKTPGPSTGKKKQQPEQDSFLVLDQKDIVACLNDLDIIFTLEDIRSPTPLKVQYVYERLVDVLLGLRRESIDPLTVPVINSNPNTSGYDPESLHDPLVWMTFFRTLRDLMKWCGVQNFSFNDLNKPEPGRLRLILSLVINFSRYRADKLDMANAVKDEHIATQYRTGDIFDANIDLRERIERIHAQREVDAPQIEQVQKENRDLADRLKELKKKQTAVSNQYEQLRGMRKEHVSKLQNLQYMVEMNERECAKLRPCVMETPERLQVVLDDLRKQLDKEREGVDKGERWIKCFQRSEESQGIVHQEVVQLVDTMEEIHRSMGKLDETTKKVQRHQAIIGQKETEVREITRKRERLTRNLKTAEEKLDQERELDQQLREQAVRRTKQLGEEYNVISEELNRKNREIEREYETTKIQMQEMMDMKAVLDDEVSMTQAQFDRLARQITEYMTKMEHAMAGAAQVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK99</accession>
    <name>U4LK99_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK99"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="110" mass="12885" checksum="FAAE5E35CBBBE0DC" modified="2013-12-11" version="1">MKEYHGCHRLAQRLWKGLSAAGLYYRDSDGDLVVKRKPPKNQWIPTHILLGVFPGLFLELNAHKPALTLKYNQRRDLLETTLSLNLEEIRYKLDLTWKETPSRFKEIGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKA2</accession>
    <name>U4LKA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKA2"/>
    <dbReference type="OrthoDB" id="10447775at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="39847" checksum="54F811633D0BE3B3" modified="2013-12-11" version="1">MMRSAPATPRGSREFTPTTYDRPPISQAPISEAPISQAPTPSCGVCRTRASCISCRSCINCRSCPSCKECRRCHPKQVTDPNDVDFDNCTCSKRFGIEHLLSFWLDILAASFLLVHCFHFCGIPLLPFYILTSLSYCGQSIFLILRSRYLDEPHARPCQWPALLSWHWKYLLFDMAFLRYIPRFVTLMYITVGLKQENWFIIIIMLVMSFPLLPLDLLFIFDVRKRALRVAKEGGEYAFLPGDEFEVNEDGQKTEGDGGEEGQEKKEEKNRFVHRNNAMLACFIGLLLLVFCIWMMDENLKMSPSEDDSQEDLRVKGWLRDAATAYLQRFGPTEDGPGTKVVVDFVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKI8</accession>
    <name>U4LKI8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="11">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_12774</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6)-methyl-ATP + H2O = N(6)-methyl-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-methyl-dATP + H2O = N(6)-methyl-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O(6)-methyl-dGTP + H2O = O(6)-methyl-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="11"/>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKI8"/>
    <dbReference type="STRING" id="1076935.U4LKI8"/>
    <dbReference type="eggNOG" id="ENOG502S254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WEETRIW"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="22">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCX13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="241" mass="27515" checksum="2E87C27A0C967CB8" modified="2013-12-11" version="1">MTVSNSTMTPPIAKPHKLYNLILPISLERRKVLLGYKRRGFGVGKFNGFGGKVEPGETIVASAKRELEEESGIICTEDQLHHHAVLLLETVAPGAEQEKILEIHVFVCTEWTGEIVETEEMSPQWFSPEDLPLDQMWEETRIWMKTMLEVYLSNDDTINNKPPSNTTAVSDIATESKELSSRNKRFVHYVDYRGGMNEQAGEWDPWHGMDTNVLEWTGKTINAWCKEDMMEWASKIRSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKK0</accession>
    <name>U4LKK0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LKK0"/>
    <dbReference type="eggNOG" id="ENOG502R9YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YVNPFDQ"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="7">
        <location>
            <begin position="567"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1063"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1498"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="1035"/>
            <end position="1051"/>
        </location>
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        <location>
            <begin position="1505"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1568"/>
            <end position="1579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1579" mass="173067" checksum="98ECB91D737A24A9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKP3</accession>
    <name>U4LKP3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peptidyl-prolyl cis-trans isomerase E acc. no. A4FV72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKP3"/>
    <dbReference type="STRING" id="1076935.U4LKP3"/>
    <dbReference type="eggNOG" id="KOG0111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YKPVWID"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="153" mass="16652" checksum="F2C7D0060151976E" modified="2013-12-11" version="1">MSDATRLKCTVYVGGLDKTVTKPVLQQAFLPFGEVVEVNIPTATDEQHQHRGFGYVEFENQEDAAAAIDNMDQAMLAGRFVTVAQAKPQKDVGNVLGSKVAVWEQEEWIRKYEVSEEDRAAADQAKADAMVKAVDPMQGLEGLDVAGPKPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKR8</accession>
    <name>U4LKR8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_12442</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKR8"/>
    <dbReference type="STRING" id="1076935.U4LKR8"/>
    <dbReference type="eggNOG" id="ENOG502S7S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WETIFYY"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12900" checksum="52B793CD939EF24E" modified="2013-12-11" version="1">MLRPTVARVIRASRVTRQIRKGSSHSGPHYDPPSGWFLNQNPAEPVKKEAWEPIFFYGFCGSLLAAGVAYAYKPDTSIQTWALEEARRRLETEGVIPDSTKPRKITEVLKTVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLE1</accession>
    <name>U4LLE1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_13789</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLE1"/>
    <dbReference type="STRING" id="1076935.U4LLE1"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FVWVIKS"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="321"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="702" mass="78012" checksum="D17887C9F559D3C6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLF7</accession>
    <name>U4LLF7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLF7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4944" checksum="FD51E0CE406E3744" modified="2013-12-11" version="1">MSWLKLFLRSADEMMLRTQMTREIISVYGFSVSTLYRKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLU3</accession>
    <name>U4LLU3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Arabinose-proton symporter acc. no. P45598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_13754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLU3"/>
    <dbReference type="STRING" id="1076935.U4LLU3"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRWYLTK"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
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        </source>
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            <dbReference type="EMBL" id="CCX32903.1"/>
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</entry>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Kumar A."/>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01593"/>
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        <source>
            <dbReference type="EMBL" id="CCX16680.1"/>
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            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQI1</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="36"/>
            <end position="46"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
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            <end position="483"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        </source>
    </evidence>
    <sequence length="576" mass="63187" checksum="4943ECBD881E632E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQI4</accession>
    <name>U4LQI4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Reticulon-4-interacting protein 1, mitochondrial acc. no. Q924D0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936394">
        <property type="protein sequence ID" value="CCX34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQI4"/>
    <dbReference type="STRING" id="1076935.U4LQI4"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDCAGIV"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="362" mass="38630" checksum="69090A9BB8C3DE13" modified="2013-12-11" version="1">MADPRPSHASSGTMRSLAIPAYTTPKNYTINSITMPTLSSPTDVLIRVSAASINPVDTKVAAGSFSFMHTATFPYAIGHDCSGTIVAVGDEVTEFVTGDEVFTMLPVTRGGAASEYAVSDASRLVKKPPSLSHIQAAAIPMATLTSTQALDRGNALLEGGLEGKTIFIPAGLSGTGSAAILLARNVFKVGKIITTVSTNKLPLVAQYLGEGTVDQVIDYQEKDVVKEVGQGVVDLYYDTAATCMAHLGIMKKGGTVVSITSMCRGETMDKLMPAPWLIKKFLDLAYGFNSWRVGRWGCKWDVLLTVLDTADLERITRWTEEGKYMPVVGKTVKLSNGDEVRMGCDAVYQGKGGVGKFVIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQP3</accession>
    <name>U4LQP3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQP3"/>
    <dbReference type="OrthoDB" id="10416887at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21640" checksum="FFC9A4EDEDC5B5AB" modified="2013-12-11" version="1">MVISHHQLFPTPAMSGLGSLHKDEAPGIPDPAIIIGPIKERKASPAFKQPFYVAPITFVAGNDLPHNWAKDWKRICDIGRESLSKYTARIPRKYDSIGHFITIGHVTDWWEPVAEVTDLSPGMEKYFGAEWRKLLVSLSGSSNKLFLYIFAAANGWHVRYSLEELKAIDYSISVLGEEVQVLEEFFEKYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQT3</accession>
    <name>U4LQT3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQT3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9080" checksum="2AC42AD4EF2F675D" modified="2013-12-11" version="1">MSRSRASTMEHMAGAKSVFPSNTFGHKASFDSDRTSNHSKSKVNKYGRSGGDWLFGSFSFRKIFGIKREDRRLAVPESYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR77</accession>
    <name>U4LR77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Endoglucanase C307 acc. no. P23340</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR77"/>
    <dbReference type="STRING" id="1076935.U4LR77"/>
    <dbReference type="eggNOG" id="ENOG502RDG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="96"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="488" mass="56538" checksum="4CBDFBE0DFB49CD1" modified="2013-12-11" version="1">MPGILKVSGEHIVDSTGTPVILRGAGLGGWMKSVLPFLPIPPHSFPFLTWVRKHSMENFITGYPGQEHQHRAAMLKVLGPEKYNYFFEQFLHQFFTASDARFFRSLGLNCLRIPFNYRYFESPLNPRVLIPSGFHHLDRIISLCSAEGIYVILDLHSLPGGQNPDWHSDNPSNWAGFWEERDYQDRVVWLWEQVAGRYKDNEWVAGYNPVNEPCDAEHTRLLAFYDRIEEAIRKVDPNHILWLDGNTFAADFSAFNKVLPNCVYALHDYSNMGFPAGDRYKGTPEQNDKLERQYLRKAEFMMSHKSPVWNGEFGPVYSPPSEPEATTINQERIALLGQQLKIYDKYKISWSIWTYKDIGVQGMIYTSPESKWISTLKPFLDKKQAIQADAWGYHPNPEVDAIFKPLVEWIKKVAPEVENKYPTTWNTERHVARVVKQCLISECLSMEFAKYFEGMGFEELEEMAKSFSFEKCAQREELNRTLRDHAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRF8</accession>
    <name>U4LRF8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRF8"/>
    <dbReference type="OrthoDB" id="10310575at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652328" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="185" mass="20520" checksum="285AA249EF896C01" modified="2013-12-11" version="1">MHFFTPLIALFSLTAAVAAQSEYKPAGCFVPQVILGSLPNEFTLQLQSEEHKKTGTLSYKRSKDQYIPGLFGGGEIINSTLSNGMLKLDNGPVGYIVEPRGKPRYLRIQFMNNPKEAAGYEAYYRCYKDKAQLVVRPNSDTGLTFCLFPEGQRRRDLGLWVKPSSDNSADCFAVTAVVTDGVRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRG1</accession>
    <name>U4LRG1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_11987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRG1"/>
    <dbReference type="STRING" id="1076935.U4LRG1"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX31910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="39654" checksum="C3364C94A4624A46" modified="2013-12-11" version="1">MPSTHNVDKPWDTEDIDKWKIEEFKPEDAKCGPFLNESDFQVKFPKYREQYLREAWPLVTRTLEKFEIACQLDLIDGSMTVKTTRKTYDPSSILKARDLIRLLARSVPVPQAIKILEDGMAMDVIKINGMVRNKSKFAKRRQRILGPNGSTLKALELLTGCYILVQGNTVACMGGYKGLKELRRVVEDCMKNIHPIYHIKELMIKRELAKDPALANEDWSRFLPQFKKRNVQRKKPAKVVDKSKKVYTPFPPAPEKSKVDLQIESGEYFLSKQAKERAAREEKEAKRKEKQIEKQKEREKDFVPPMEDGDEKKSKKRKRDETKEERKARKEMEKLAIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRG7</accession>
    <name>U4LRG7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_02664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRG7"/>
    <dbReference type="STRING" id="1076935.U4LRG7"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEDHPWE"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
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            <end position="186"/>
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            <end position="247"/>
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        <source>
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        <source>
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        <source>
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    <sequence length="709" mass="78352" checksum="4132EB04C7B03980" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRL1</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Pezizomycetes</taxon>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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    </evidence>
    <sequence length="1371" mass="156043" checksum="0E7DFB6D5FCDDBA4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS26</accession>
    <name>U4LS26_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Ras guanine nucleotide exchange factor J acc. no. Q8IS14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS26"/>
    <dbReference type="STRING" id="1076935.U4LS26"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIAKWVA"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="646"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="868"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1125" mass="123685" checksum="91F8702FFE709389" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS63</accession>
    <name>U4LS63_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Probable prefoldin subunit 2 acc. no. Q9UTC9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS63"/>
    <dbReference type="STRING" id="1076935.U4LS63"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13408" checksum="28B5C15A04456A49" modified="2013-12-11" version="1">MSTSNAAAAKKQQELQIQYGNYKNLLQQLATKIGDVEQEAEEHRLVLETLGPVPKDRKCFRLINGILMERTVADVVPALQTNAEGLKNVLEGLVKQYKDKQQEMETWKTKNNIKVVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSX9</accession>
    <name>U4LSX9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">PCON_08660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSX9"/>
    <dbReference type="STRING" id="1076935.U4LSX9"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGKKWFP"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCX30636.1"/>
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    </evidence>
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        <source>
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</entry>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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    </feature>
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            <end position="606"/>
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        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119278" checksum="3C32D89163615142" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTY6</accession>
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        <submittedName>
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        </submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="294" mass="32181" checksum="1C7FC0346B724E25" modified="2013-12-11" version="1">MASSKENRVAVITGACSGIGLALTKDLISRGWRVALGDVESSGGDYLFSLFPLGSSIYVETDVTSWESQSALFRAAYEKWGRIDFHTANICVGDRENIFPRRNTIGNPHRAIQRPDLQALEVDLTAVVYGTYLALHYFRQTPGKGGQIVLTSSLAGLFSLSIAPQYIIAKHAAILIKSQLMGWTKSMAPNLAKEGITINAILPGMMPKSLMAERTPKFPKELMTPLGPVLKAFNMFLENPALNGVCAECSSGDVYFADLPQSSEAEMMDNRRKEMVARLNGKQVGKNYVVRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU37</accession>
    <name>U4LU37_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU37"/>
    <dbReference type="OrthoDB" id="10442654at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="213" mass="24135" checksum="D2A0171423E42E24" modified="2013-12-11" version="1">MSVPPISAHSDLTSFISPSYPRPRYTHDCRFRNPYPRLPTTDDLITIPTLLSPPFHSKLPPRPPVAPYLEIIIQRILNSFPPSWLLEPKSGEMFRTKQDATRRMQAFAFYSGVALYPEYNRKGRADKMRFSCVHFHPKWEERRIVEIPGTQSLGRNRLIQRVVRSFSGGGLRSVGLGCRCNVNLVRRSVGNGEGKEKEVWVLAFVGAVLVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU58</accession>
    <name>U4LU58_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU58"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="21" mass="2365" checksum="592F276119511AC5" modified="2013-12-11" version="1">MVVGALSLQRVEGRIEFLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU73</accession>
    <name>U4LU73_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936091">
        <property type="protein sequence ID" value="CCX33450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU73"/>
    <dbReference type="OrthoDB" id="5328442at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47163" checksum="449A16CEF6B12FA7" modified="2013-12-11" version="1">MAMIPINPTAPPWLEQFDLATLISECNFSINLHPSGLRSSRINDPLVDGLLDTVLTQARIEPSDYERDMARRHLAVKLQMLFRVWVEEGLKATMDGSQLYSYRKRSYEGEDADIQGPAKRVADGFVGDRDFRCPYIVRNPDDKQHKECEGKRFPNPRKLKEHIWRFTKPFKCPTCFEGFGREKTKAIHCDQRKVKCVPAEQNHYDGSHEQHRDRSIDRAKNTPEIIQIFEEYEDAVGVNGQSAYSPGSMSQASMPSDDDEEDYHQQWTIDTRKSQQQPISLRIPKPYPTPPPPQNGFSPVVSAATYSPQQTALYSPANTTAAYSPHDNFNTTANLFASYPVPQIMVTSEQAPQRSPLMEYGVPRNGQQEKQAVIHSQMPYRTAFTTEGYKSFPPGPVSMRFRDDVDVAWSSHVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVN8</accession>
    <name>U4LVN8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVN8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="11333" checksum="99EC3C73F0DA6E93" modified="2013-12-11" version="1">MSAEPNHEEINRKEATQADTAVPEISVPGSDECSMDSSSDSMTTGTADSTSLATTSLVDSEKMCNDAKRGEEDAVKKPIKVEDKNIKPQVKLNGMEQCGGLATLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW14</accession>
    <name>U4LW14_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Coiled-coil domain-containing protein 12 acc. no. Q8WUD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW14"/>
    <dbReference type="STRING" id="1076935.U4LW14"/>
    <dbReference type="eggNOG" id="KOG3407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MLVQGIH"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="205" mass="22998" checksum="BFA4E238BA1E2528" modified="2013-12-11" version="1">MSASLDAAAAARKARLSQLKSLKRKVDPSGPSGPADVPTDDDVPSVSTLAIKETKKKDSTEKDVSHLLSGRNYDKEERAPKMGYASNPAEGKETAEAIAARIAEETRQKRLEAEKEDKPIDLFNLQPKRPNWDLKRDVDKKLEVLGQRTDIAIAKLVKKRIEEEKAKKEATGEEDEDKVDINLAKMVERREKEKSDDEEEDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWC6</accession>
    <name>U4LWC6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Bifunctional P-450:NADPH-P450 reductase acc. no. Q9Y8G7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWC6"/>
    <dbReference type="STRING" id="1076935.U4LWC6"/>
    <dbReference type="OrthoDB" id="5396067at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15656" checksum="847703D635126406" modified="2013-12-11" version="1">MYDIASELVMKWARHGPEHRILAADDFTRLSLDSLALCTMNLRFNSFYKDELHLFVHAMSIPTLSFHCVDAWIERQVRGRQNPKKDLLTCMVEGRVPKTGVIDNGLVVKNLITFLIVCNAGVNFDHRHDAPAFQFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXF1</accession>
    <name>U4LXF1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXF1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6529" checksum="DA11A5382AF8C80D" modified="2013-12-11" version="1">MLSVEFWSSCRGCLRSGTRARPRRCEWPRYSEFLATGVLGLGTRPEVGCALRGLLRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXQ4</accession>
    <name>U4LXQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936570">
        <property type="protein sequence ID" value="CCX34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXQ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="7990" checksum="24A1A01B78802BA2" modified="2013-12-11" version="1">MQRARRVMHPASASASSTMSPPKTHLLFFFAVVAFSLAIAFSSEFRALLSYYTPLTPGNRDIHRTPYQEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTQ2</accession>
    <name>U4KTQ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935124">
        <property type="protein sequence ID" value="CCX04222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTQ2"/>
    <dbReference type="STRING" id="1076935.U4KTQ2"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="350" mass="38721" checksum="4D4F22A1B88045FE" modified="2013-12-11" version="1">MSAADTYHEAENRAPQILAVSYTILSIVILSIVGRFYSRRHLLRAIHIEDWLALLACVNLTIYVILYTFMTTLKFGHHTSAIPASNLKKLFLLSACSRLLYPPTIALIRISVLLFMRRLCPHVCVHIAVAVLIILNILFSIISVLLMVLRCYPIAFFSSNEIGSQGTKCLVDDSTVALAIPITSTSIHVLMYFVPVFTVLRVSFLGWGQKAAAVGLFTAGHVATMLSLYRLPAVKRLHNGVDPMWNAASVAQWTVYETGVSIILASTPSLWALLSNTMKKCGYWSTAEYEPKSPGSPETDWERASSRFPTRPVSMVTVPLGARRTPRDSYEELFLGTGVDAEEPRGSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTQ9</accession>
    <name>U4KTQ9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWI/SNF and RSC complexes subunit Ssr4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTQ9"/>
    <dbReference type="STRING" id="1076935.U4KTQ9"/>
    <dbReference type="eggNOG" id="ENOG502S04K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="387" mass="42349" checksum="3A61DD64FDBE5580" modified="2013-12-11" version="1">MLHPSFPPAGGHPQTPQRHQHMPPVPSTAPRAGIPPPPAAGHYYTPQHRPPPPPTSKSRTRGPPPTPQAALLTTDATMTIDEEEDTSRGDILDHFSPRELALQRYTQHHEWMEEVIGSAYRIGQIQPVELGLGLEGTGERVGVEGVTRGLELGAPKQGAPKTGEIKTQKEVLEELRKRAEEKMGEMEKEMEELRKLHDARMRSLAGLSVYRQAEMDLRGGLSLGELGLKPLSSGEEEETMDSVSRHTSPEKSGKSVEEVKKMVEEKTGRKIEERKEFVVRKLEDEMILKLGGVTGKPPVLGGGSSAAAAATVAAAGAQSTGAEPVEGMDTQLDGMDERMDTLQEEEFKLDIPTPNEEVYEDQIMADFMETAEPGRFEEEMGAGLDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTR0</accession>
    <name>U4KTR0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_01283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTR0"/>
    <dbReference type="STRING" id="1076935.U4KTR0"/>
    <dbReference type="eggNOG" id="KOG0142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEWGEHE"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="14">
        <location>
            <begin position="192"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX04263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="370" mass="41343" checksum="DEAEBEA7BA380DAD" modified="2013-12-11" version="1">MQFLILQTIIAPLRRSFPKVAQNSRSYYTIANRKQTVVLGARARARAVICPLPGVGSHGNKCSQHQSAARFRSRTQGTQGDTSSASASAIRSFSTKSNSASTLETPTPTNTEAAAAMAHPKITAENIYQLFPEIEQQRNTSAAAVGTELQGYDATQVSLMDEVCIVLDDDDKPIAGASKKICHLMTNIERGLLHRAFSVFLFDSEKRLLLQQRADEKITFAGMWTNTCCSHPLDIPTETGVSLEEGIVGVKNAAQRKLEQELGIPAAQVPPEIFKFLTRIHYKAPSNGPWGEHEIDYILFAQATVDLAVNPNEAKDVRYVTPQELKAMFQDPELTFTPWFRLICETMLFEWWENFETLDKYLGEKEIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTU9</accession>
    <name>U4KTU9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Activator of stress genes 1 acc. no. P40467</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTU9"/>
    <dbReference type="STRING" id="1076935.U4KTU9"/>
    <dbReference type="eggNOG" id="ENOG502SH73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DLDECDC"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="822" mass="93456" checksum="5B8058257223BA42" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUJ9</accession>
    <name>U4KUJ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Polyubiquitin acc. no. P0CG74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935216">
        <property type="protein sequence ID" value="CCX04742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUJ9"/>
    <dbReference type="STRING" id="1076935.U4KUJ9"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSDEHTL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000469">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="130"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27649" checksum="5D37E7561164B93F" modified="2013-12-11" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPRTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV01</accession>
    <name>U4KV01_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV01"/>
    <dbReference type="OrthoDB" id="3039892at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650773" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13737" checksum="BD9E0CD1E6E994B0" modified="2013-12-11" version="1">MQFSKLSTIALLGFFSFTNAYDMYLKGCSTTNGSPTVADINKVIDGLNRKHGCSQNNAFGTQCTTIQTNGGAHAGLCGYKWGWGNNKDMEIDCHIVANAAMLVINKCSGAGGRASGEVQVSDVMRVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV71</accession>
    <name>U4KV71_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV71"/>
    <dbReference type="STRING" id="1076935.U4KV71"/>
    <dbReference type="eggNOG" id="ENOG502SHYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20693" checksum="8FFB9FC1F4AA87FC" modified="2013-12-11" version="1">MDWYHCKLEVMEKVKESGLEYTAFRNGQLINYWAHGSPHLKAVEEGLAGMGFAFVVDVGNETAEIPGTGDQKVTFTRTQDVGAFVAAAVGLEKWEEEMGMGGETTTYNKVVRKVKEMGRKMEVTYRSRDREDGGRKFYLQAMLAVAKGEGEIKMRLNELVPEIKLWGVDKFLGIWWGNEGSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVD7</accession>
    <name>U4KVD7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized J domain-containing protein C17A3.05c acc. no. O13633</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVD7"/>
    <dbReference type="STRING" id="1076935.U4KVD7"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="366" mass="40177" checksum="572733C369775FE3" modified="2013-12-11" version="1">MSTGTTSGSKPSSSAGSAKFREHSHGRQDREYTSEQKAAVERIKRCKPTAYYEILSVEKEASDGQIKKAYHKLSLQTHPDKNGAPGADEAFKLVSKAFQVLSDSQKRAIFDQTGGDPESRGGMGGGGGMPTGNPFAGFRGAQPGMGGMGGMGGDISPDDLFNFIFSNGMGNGGFFNANTMFDDARGGFAFGGPGIRVHQFGGGPRMQRRRAAGANAQQEAEEGQAGLSRIFWQFLPLILFFLVPMLSGLFGGGEERMKGPQFAMDPTAPYTQMRTTPEHKIPFYVNPKDLDGMSMRDVTKLGQRAEQTIVNKWTNGCNREEIVRQQMLQDAQGFFWTDQDMVKKAKEMEMPNCRKLQDLGMQRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVF0</accession>
    <name>U4KVF0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="HF935256">
        <property type="protein sequence ID" value="CCX05518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVF0"/>
    <dbReference type="STRING" id="1076935.U4KVF0"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAPHTYD"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX05518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="435" mass="47544" checksum="AC25FA36BDC78665" modified="2013-12-11" version="1">MIAEKLMTLYPGDKPGGTPGLFGEPYYWWEAGAAFGALVDYQHLTRSTQYQDVTTTAILHQVGPDINFQPPNQTHCLGNDDQVFWAFASLTAAETNFPDPPPSSPQWLSLAQAVFNIQSTRWDPEHCGGGLRWQVYNFNRGWDYKNSVSNGGFFLLGARLAKYTGNGTYAEWAEKTWDWSRDAGLIDAEGGVRDGMDVNVCKIDMDGGDGRVMWSYNAGIYLAGAAVMWDVSEGPAKEKWKSAIDFLLPRTLSNFFDKNGIMFEPACEPYNKCNVDQRSFKGYLSRFLSITARVAPFTASQIMPLLKSSAVAAVKSCAAGPDGNTCGLKWYSGGWDGNQGVGEQLSALETVQSCLTPVGDGKMQIPAWVTEHAGGTSRGDPNAGMEVKEIEQNLVRIDTKDEAGAWILTVITIVSIMAMAVWVSFAPFNRPGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVI5</accession>
    <name>U4KVI5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_04040</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="HF935220">
        <property type="protein sequence ID" value="CCX04921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVI5"/>
    <dbReference type="STRING" id="1076935.U4KVI5"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIVAVNW"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="774"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1124"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX04921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1159" mass="125888" checksum="A547AD1A7138F61E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVK0</accession>
    <name>U4KVK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein MGR2 acc. no. Q02889</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_04091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVK0"/>
    <dbReference type="STRING" id="1076935.U4KVK0"/>
    <dbReference type="eggNOG" id="KOG4096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCWDRVK"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="113" mass="11893" checksum="7BE334A342E4D0FA" modified="2013-12-11" version="1">MPPVAQIPQGHGHGAPSTFDKMKMGAMMGGIVGLSIGFIFGSYSIIKQGPGPNGIIRSLGQYMIGSATTFGFFMSIGSAIRTEGPEGSMQKFAAMRAAPILMAVQAKRAEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVL4</accession>
    <name>U4KVL4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CBP3-like protein acc. no. Q9USK6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935262">
        <property type="protein sequence ID" value="CCX05643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVL4"/>
    <dbReference type="STRING" id="1076935.U4KVL4"/>
    <dbReference type="eggNOG" id="KOG2873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRNLYKG"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="122"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="287" mass="32072" checksum="130DEE808E4B769A" modified="2013-12-11" version="1">MASRAFTAPLRLVAQKGISIPAVRPAAARLLTTTATPLQAITPADPGAPVNPAAPLAPNVSALNQNLSIADKIALRFKDYLPNTTETYVAFDVTKELYTECALQAAYVDGVDFTPSAKFWYETCNRPPTFQSWSQVTVLHMWMLAARMRALDKGRVKTWQQHFIDHFFYDSEDKMVKRYGIKRASERGGYMKDLYHQYRGMTAAFDEGLVKGDAVMATAIWRNVFSAQEDVDLEVLATVTSYVRRAVSKLSMVDDDVVLTGRVKFGMPTDELPLVRQKSSFLEGQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVY3</accession>
    <name>U4KVY3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Vacuolar segregation protein 7 acc. no. P53950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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            <end position="610"/>
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        <location>
            <begin position="1"/>
            <end position="191"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="355"/>
        </location>
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            <begin position="12"/>
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            <end position="52"/>
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        <location>
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        <location>
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        </location>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <property type="entry name" value="Ap4A_hydrolase"/>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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        <source>
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</entry>
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    <accession>U4KW43</accession>
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        <submittedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="267"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="492"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="746" mass="79705" checksum="3D1DD627E321842C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX16</accession>
    <name>U4KX16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX16"/>
    <dbReference type="OrthoDB" id="5321158at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="233" mass="25669" checksum="DDC448A561B68FC2" modified="2013-12-11" version="1">MRPQRTNVLWKKKQPENARAVTPPRPQDDFAIIQQFNQLYMKVRAWSVEFVGGAVGSELSAQQVTLLRRLVLSNLDLAEVLADKTLHRHVIEGVIGIAIAEMLSSKTPSDTNALSETIYGQVTGFATSKTPMKELKNDLGAILAMAVSLQKSFATQTATFTVSYPRVQDGQCEFQTAMMEDKSNGKNGGPSKRLVGLLIFPGMFKVAEGVRTCMVKIKVICTDEMARYNVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY28</accession>
    <name>U4KY28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized transcriptional regulatory protein C11D3.07c acc. no. Q10086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY28"/>
    <dbReference type="STRING" id="1076935.U4KY28"/>
    <dbReference type="eggNOG" id="ENOG502S2DS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="285" mass="32704" checksum="0F66A8749603BE48" modified="2013-12-11" version="1">MDGVNRSSEKLASAIPSYGHTLFRKNAAMVKSCIPDKVDAMELIEESYKFAYTWFPIFDKTSLLSDIENYHTFHSPSKDKPFTICINTILIFGLYSKLLNSPPSLRPSLSLYSRQRTETYFFAAWSALDDLEVDTTPKLRNVQALFTMSMYAIELSRPALCWGLLSQAARLAQALGLHRRTKPDHHQGGRGGGGAKLTEGQIEERKLLFWCIYILDKQVSLIFGRSACLPELIVMLNYPLARQGWGCILGIGWLLLDWRRYSRRYILSCIQRRHLCKIWGNGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYF9</accession>
    <name>U4KYF9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to ABC transporter G family member 11 acc. no. Q55DQ2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_06598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935330">
        <property type="protein sequence ID" value="CCX07011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KYF9"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YCAQFGM"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="260"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX08019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="451" mass="49904" checksum="03014D365257D088" modified="2013-12-11" version="1">MSSEIPALVADKISPRAKELLAKVTKFVEEECQPAEVILESQIPSDPSKRFLNSYPAIIDTLKAKAKKLGLWNLFLSNIHYREGVALSNLEYALIAEQLGRCPVASEAMNCSAPDTGNMETIAKYGNDAQKKQWLTPLLNGDIRSAFVMTERFVASSDARNINLDIKRDGNEYVLNGTKWWSSGAGDPRCKIYLVMGKTDAANPNPYKQQSVVLVPHNTPGITVERALSVFGYDDAPHGHCEVSFKNVRVPVSNILLGEGRGFEIIQGRLGPGRIHHCMRSIGVASVALELMLLRVNDPNRQTFGKPLSQHGTILEWIAKSRLEIDAGRLLVLNAADQIDRSDAKGALKNIAMAKIYVPSMALTVIDRAIQAHGAAGICQDFPLARMWASMRTLRLADGPDEVHMNQLGRLESKKVKELAETYKKRLARTEQLIQQMGITLKDHLELKAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0S3</accession>
    <name>U4L0S3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0S3"/>
    <dbReference type="OrthoDB" id="10564560at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651568" evidence="2">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="292" mass="31497" checksum="9BFF4825A389446C" modified="2013-12-11" version="1">MHTLTLLLPLLFPIPLAFSAAPEGPEGRQCHWLIATSSPRLKTISGHLSCCAPIGTVLNKNFPTAEEIANNARTIESQPALKIPTNLVNGGSGKEFEDDDDGKGKGKGIVAGIVDGVKGGLGGIGNAVKGGLGGIGNAVGKLFRRRGEEEPVEVTTPVLKGKQPATLPQQKKPQQPQKPQQPQQQQPQRVNLTTPAIAPNMRFGNWNRFKKQKPEVPKSTFKPWLGPKEEDNRDRKAPVIEEWPEIDGEKVVCISSQGGLCPGGWKQTWCCEEEKGEKEGNGVGCVDSWIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0W6</accession>
    <name>U4L0W6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0W6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="162" mass="18302" checksum="55E45E1BFE806080" modified="2013-12-11" version="1">MDYPNSALHALLRPTVHIRCCLLIANLESPSLPRVYISDVVHDVQPDNRHHCATKRVPSFLDQRSLFFVRVRRGRSGMVSQPSSHLSGQNSSPTRLQKNVCYQTPQSAGSTWLLFAVFARLCLFLWQVRRVINGLPSPHPTSYLRARVALAISPQRFPTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1J5</accession>
    <name>U4L1J5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Protein hid-1 homolog acc. no. Q8IV36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1J5"/>
    <dbReference type="STRING" id="1076935.U4L1J5"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TANSGWM"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="983" mass="109074" checksum="D6C132103E712466" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1L3</accession>
    <name>U4L1L3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Cell division control protein 1 acc. no. P40986</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_08914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="756"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="869"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX09321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112026" checksum="A24E61D8F000850F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1N9</accession>
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        <recommendedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18058" checksum="B43ACCB4E15744FC" modified="2013-12-11" version="1">MASATEAPWHAAFPKPKAQAEFISREDTLALFSSAKPGKDFILVDVRRTDFEFDDKEMLNIQGGTIKNSVNFPAHSFYHIREAVYDLVKAAGVKTVISYCGSSNGRGPRVAGWLQDTINEKGDDSIKSVAMTGGIKGWAKAGEEYTSQMVGYEKEAWETKPDGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1T2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935420">
        <property type="protein sequence ID" value="CCX08566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1T2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="7301" checksum="4C945D8D050AAA47" modified="2013-12-11" version="1">MQRRFHRPNIPFLIHRVTLTLKLSRTRYYTLHRHPIFHPNRKPYYPSTYCISYYCSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L206</accession>
    <name>U4L206_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935434">
        <property type="protein sequence ID" value="CCX08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L206"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000005">
        <property type="entry name" value="Gtr1 g domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="446" mass="50347" checksum="A87FC8C3BF11E90D" modified="2013-12-11" version="1">MTSFYTHLPLPADPPNTSPERRSSYSLERFLQEPEQKELSPASSIEARYLDTAEIALRHKRMQDQQSPVNSMGAYGLPPPGQQRGRPRLLLMGQRRSGKSSISSVVFHKMPPMETLFLESTTKIQKDPIHSFMDFQVWDFPGQLDYLDDTFDFDNIFGELGALIWVIDAQDEILDPLSRLHSTIIALQRSYPMINIEVFIHKVDGLSDEYKLDTMRDIMQRTQDELADAGFDNVQISYHLTSIYDHSIFEAFSKVIQKLLPQLGTLENLLNVLCSNSGIEKAFLFDVLSKIYIATDSSPVDVQSYEICSDFIDVIVDVSEIYGYDRKNPDEAAQPSPPVSPGAAPAENTQEVSSIIKLQNGMVLYLREINKFLALICLMRKESIEKKGLVDYNVQIFQNALQRVFELGGGVRVALAQGPDEEEQQEAAHPEPWYRRLCVEGSGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2J5</accession>
    <name>U4L2J5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to lysophospholipase [Exophiala dermatitidis NIH/UT8656] acc. no. EHY52934</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935468">
        <property type="protein sequence ID" value="CCX09514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2J5"/>
    <dbReference type="STRING" id="1076935.U4L2J5"/>
    <dbReference type="eggNOG" id="ENOG502S56Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650989" evidence="2">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX09514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="20769" checksum="055BD234E6DACCE2" modified="2013-12-11" version="1">MKFSLIAVSAFFTLTLASYKQPTTQLKNLGAVRLPDSEHPVTAGKDFEIVWDAEGLSTKPISLLLLHGCPSNCSKVLDIITGIPTNHQLRDKKGTFKWNVPQSLQDSNGKLKYGIQLVVDNTGEFQYSTAFAVVGGLKQYMKEGTGKRDVYAATNLGTGTKGDGFVTTTKVTTVESTQVVTVTKERGYMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2M1</accession>
    <name>U4L2M1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to NADPH-dependent 1-acyldihydroxyacetone phosphate reductase acc. no. Q09851</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_09747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2M1"/>
    <dbReference type="STRING" id="1076935.U4L2M1"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MYFEPER"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX10154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="351" mass="39267" checksum="8BE34C950F0BBB2E" modified="2013-12-11" version="1">MYFEPERPLVLYLRLSMLKCVGHGTRVGTRCSILIGLIFCVGVKILILLTVPKYLNTPMPVAAEMITERSLIGRLSRKKWCVGYRVFAAVRRLETVKELEELGVESVYLDVTDPSSIAAARDEVAARTSGKLNVLVNNAGQGSPRPATDLEIETTVKGIFDVNVFGVMRVVQTFVNLLVSAAGDGEEATIVNIGSIAPIVPLVFGSAYNASKAALHAYADCLRMELRPYGIHVLTAMTGGVRSSIVRRTASDIPQNSLYRPIYDSWLKRIGLSQSTPMDTATYAKGLVDEVVRGSKKPWFWRGHFAWRAWFLNTFLWKGFTDYFMMKRFGLVKLENMMNEQRKLKSKQKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2N4</accession>
    <name>U4L2N4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_09224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2N4"/>
    <dbReference type="STRING" id="1076935.U4L2N4"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCPVDHK"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX09630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="280" mass="30761" checksum="4ACC9F4699D7CE6D" modified="2013-12-11" version="1">MTDSTKPESSCPVDPAARSRWTSLFSLGGGTAPHPIPAKTENSTAQESCPVDETARAKWLSQQALASNDTPKTATTGKSCDSSEIAAASATSPAMPSNHPGLGKVREVSTIPRANMDGSNSEHTAASISTTTGNWIYPSEEMFFNAMKRKAFDPKAADMRTIVPIHNAVNERAWAEIKKWEEGYGSEKCGGPKLASFSGDSQKMTPKARFFTLMGYHPPFDRHDWTVDRCGQKIEYVIDFYSGKSDPKQPERVSFYLDVRPKISVEGVKMRMGKFFSELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L313</accession>
    <name>U4L313_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C594.04c acc. no. O74507</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935540">
        <property type="protein sequence ID" value="CCX10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L313"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRKGGYQ"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="353" mass="39896" checksum="A237F9E8190004DD" modified="2013-12-11" version="1">MSSTTLPLPLPSLSTLHDCASFTLTVRPYLHQLSFAHISTLSLFNGPLSFSEWYLATNPLIMAGIISLVVAALVFISAEINRNYSQIDRLWPILPAVYAAHFAVWARANGVGSERLDTLATAVGLWCIRLTYNYYRKGGYKWGAEDYRWIIVKSRMSSWAFVIFDLTFISIYQSLLLLAVTFPCYLLLLVSQIPGHGAMTTSDTVISRILAVLLILETLADQQQWNYQQAKAAYKATGKVPEGFTKEDLDRGFVVSGLWSIVRHPNFTCEQAIWLGVYQWGCWQTETLWNWAGIGALGYCAVFQGSTRLTEDITGKKYPEYREYQRLVNCFVPGFRSFSAPQMVEEEKGKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L344</accession>
    <name>U4L344_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L344"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8990" checksum="1D07B576ED85C741" modified="2013-12-11" version="1">MYDSDVKDLSPNETVFKTRWLKFNHKTNFHHLLIKLYQRSLLTSVHRLLHHSFQFRLLVQYGIRLVFNKKMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3F1</accession>
    <name>U4L3F1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Ran-specific GTPase-activating protein 30 acc. no. P53107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3F1"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="809" mass="89651" checksum="AC44384F128E4AAE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3I9</accession>
    <name>U4L3I9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3I9"/>
    <dbReference type="STRING" id="1076935.U4L3I9"/>
    <dbReference type="eggNOG" id="ENOG502SAX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="229"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="478" mass="53861" checksum="89B8392F7DE34320" modified="2013-12-11" version="1">MDPLSVSASAAGLLSLAVGTAGILKGLMDGAQSAPEEAQNLLAEITTLSDVLQDLVQFLRTDHLTEQRFEKTSVLRMTIESGQDRLKLLYSKLDRLRASFDGNKLKVLVARFTWPLKKEEKLLSETTSVFLTKLDQNHADIQNIVSGLEKLNISAPPDLIEKCAEISKLQSLVVDLASSNARDIQNISLGMDNLQERFNDKDFKKILAWLSPLEPQKRHHDIRQKRLPGTGDWFLLEPKFQEWLSDRTPGSDVSSILACSGIPGAGKSVICSLVVDELGTRITKSPESRACVAYLYCDYRDEKNQTPFNMIGALLKQVLSTLSESKSVPQDVFSLLQKRWDQEKNFKLDEVRQLLAKTVRRLSNVYLCVDALDECKAQNRSTLLQYLAMIAKDCGQECSFRIFTTGRLHVKLEDYVRQYPDLGNLTHILLEANSDDIRRYVEHAIECDDNHDCMNDTLKAEILERIVNTSDKILVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Q7</accession>
    <name>U4L3Q7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935324">
        <property type="protein sequence ID" value="CCX06943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Q7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="7974" checksum="7196DE949532D2A0" modified="2013-12-11" version="1">MWECRDVRRSAKPCEAEAWWSCVKLHVDIEALHTKLYTVLGASYLGSYPNQPSFGFIGIVVKPLSSHCGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L436</accession>
    <name>U4L436_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L436"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4643" checksum="9DF1ECEF762C4E09" modified="2013-12-11" version="1">MESEPMAYVEASLHLIDSNKSGDSLPQHGESSIAEEIKKPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Q2</accession>
    <name>U4L4Q2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Q2"/>
    <dbReference type="STRING" id="1076935.U4L4Q2"/>
    <dbReference type="OMA" id="DIAGNDM"/>
    <dbReference type="OrthoDB" id="4204700at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="390" mass="44245" checksum="586A315B5C0F0F99" modified="2013-12-11" version="1">MVLDSIPDIPPDGSPPVSDSERTYPPPPPIPSFILTSGSFNEANRSRFINLTLAMAARDFNFHPTPVEYEGLSYYQSVFYSAEALGAMSGTLAGGLIGCVIAYRQKNPGFLFRQLPLSPQYRLWGSKLVNVIFITGLGRVWGMTSYGVKAWNEISRKQKEDPNMQRYLKMKNAWLEQRKRNAEKGVPVKAQVNWEEVKKMAETPVEVQTAERERLQGTYGAQAFGGQTDQDEQGLGGPFFEEKKWDGGVEEQQQLTRAQKWEQAARNREQRTKEEAARALAKATGKDEDEDPFFGGSEQEEREPVKTEEPKSGWRNTQSIRGGSAWDRLRRGVRQEGEMETKGDSFAFSNSDREREIAKEEAQREFDLQVERERLGEGQDGFVGEGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4W4</accession>
    <name>U4L4W4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_04672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4W4"/>
    <dbReference type="STRING" id="1076935.U4L4W4"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKREEAY"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX05085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="249" mass="28445" checksum="E17CD39EB8B58979" modified="2013-12-11" version="1">MTYQSHQRHFSRGELPSQVSFPAYLYPSGSYALDGIATRAGGLGVVFALALNAAWTWRNGFPQLPLFVACLAFFHFMEFWITARYNTRRGKVEAFILTSNGAAYNIAHASAIIEALVEYYFFPQLKALNWVTLVGLFLVIIGQTARTLAMKHAGSNFSHYVVTEKEAGHRLVTEGIYAWLRHPSYFGYYWWAVGTQVMLGNPICALGFAAFLWMFFSNRVKHEEEHLMGFFREYSDYRKRSWVGIPFIG</sequence>
</entry>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="Pfam" id="PF12937"/>
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    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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                <person name="Gabaldon T."/>
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            <dbReference type="EMBL" id="CCX14296.1"/>
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    </evidence>
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    </evidence>
    <sequence length="40" mass="4858" checksum="8543EF6324DD26E5" modified="2013-12-11" version="1">MNWKDHNTRTSWFYIYFSVLRKFAHLEVLFSITHPTEAVA</sequence>
</entry>
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    <accession>U4L841</accession>
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                <person name="Altegoer F."/>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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                <person name="Kumar A."/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="542" mass="60044" checksum="CC5F9B2DF4CEFC37" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Q1</accession>
    <name>U4L8Q1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936136">
        <property type="protein sequence ID" value="CCX15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Q1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19212" checksum="BFFD896443E42E0C" modified="2013-12-11" version="1">MPIRKDSIKKLLKQQITADVLYDGEVLDTHLAHNEKIQQDIQYTREIRQRRKQRQKLKNKMEREGKDIQGDTTMHDTTGFASVAAASPAVNPVINAISTALSGMSTADRATNEATDAAEDRQGDLVVIVDKRAGRKAEKEKTRRLEMEARRVVRLPIGLKRPREAQGRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8T1</accession>
    <name>U4L8T1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8T1"/>
    <dbReference type="eggNOG" id="ENOG502SQW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2396694at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="193" mass="21435" checksum="14FF4A1DEBC8F41B" modified="2013-12-11" version="1">MLRPTLRRDRTIIPRLDIVHNLHANYWVLALVALQKAQAATLGSCARRYWTTSWILSDNSHDGSVQIAMAVFVDCALSVHASVLVRINQDAEYNRSLFLWLIIYVIGTIICLAGLFSLLVLAWGDLWVYVLWMSLRGKVNSSICLIMLGGLPALCSDWVLAGIAGSVVGLPSRDTTALYFAYFVAKRLPLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L914</accession>
    <name>U4L914_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Methylsterol monooxygenase acc. no. Q9UUH4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L914"/>
    <dbReference type="STRING" id="1076935.U4L914"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EIMFYYA"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="141"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="35537" checksum="7AA2875FC30AE0C1" modified="2013-12-11" version="1">MSNFTTILPDTAAYWAAYDQIAELNVHLNIFEKLWAAWYQYMDNDILATGIMSFVMHELVYFGRSLPWVIIDLIPYFRRWKIQESRIPTAAEQWRCTKLVLMSHFTVELPQIWLFHPMCKYFGMDTGVPFPAWTTMAYQIAIFFVLEDTWHYWSHRAFHWGPLYKYVHKIHHQYSAPFGLAAEYASPIEVMALGLGTIGSPILWVALTGDLHILTVYIWIVLRLFQAIDAHSGYEFPWSLHHFLPFWAGAEHHDVHHEKFIGNYASSFRWWDYMLDTEAGAEAAQARRERKAAKEAAKARKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9F7</accession>
    <name>U4L9F7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935521">
        <property type="protein sequence ID" value="CCX10201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9F7"/>
    <dbReference type="STRING" id="1076935.U4L9F7"/>
    <dbReference type="OrthoDB" id="7791461at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651235" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9055" checksum="4E7C9DAC8B6EBC4D" modified="2013-12-11" version="1">MQFSTVAVVLAFASSALGAAVGVCPPWSDDKHFLLADDADCTIFWKCNPWGPVKIECPKGLYFATQHNWCDYKENAICAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9L4</accession>
    <name>U4L9L4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to GPI ethanolamine phosphate transferase 3 acc. no. O13663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_06461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9L4"/>
    <dbReference type="STRING" id="1076935.U4L9L4"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX06874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115736" checksum="BB0FBE5E1AC8856C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAK2</accession>
    <name>U4LAK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UPF0311 protein CA_C3321 acc. no. Q97DZ9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAK2"/>
    <dbReference type="STRING" id="1076935.U4LAK2"/>
    <dbReference type="eggNOG" id="ENOG502SM0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRNWISF"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651271" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23786" checksum="D22CAE732A7714D2" modified="2013-12-11" version="1">MYTPRILIFGLSLIATVLAAPQSTHPHPHDQVDINLTEKFPFISTLPLDEQPIRLPLPEPDMTPDIRMIIDIESRTPLGLGPWGSRNWIKFSGGRWASSWGNGVVLQGGQDNQLILDDLSVNFHATYVMKTNDTDPAYITVTTTGWRTGKKEILEALNDPEKAKGILPSWYKFRAVVSMESGDVRYKHLNTKMWVGTGGKWGRKVVVDGYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAZ3</accession>
    <name>U4LAZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAZ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="7330" checksum="831BDD8CAD8AC295" modified="2013-12-11" version="1">MQRRCNVECIMIQHLRTVQGEKWIALLLFHAAKYYIRTCGEHRSYRHTYQQPRRTDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB82</accession>
    <name>U4LB82_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB82"/>
    <dbReference type="OrthoDB" id="5495198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="241"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32923" checksum="FD1D1CEF41261FFC" modified="2013-12-11" version="1">MRRAPAPAAQLNRPQSTSNMRAPAADIKRQSSTQKQQKPPTSQTSTKIPAPMKKEPQFKAYETDAAYHILGSLPEGVDKKSMDLKFLDSNTLGISGCILTPQQPEIQNRSEDSDSEASDTDADTDTDSESESESEVDSEDESAVESEVEPETKTDTRSLQPYIEDIPDIDDPRTPAALASLQMRRGSSCSSRSSASSSASSSCPEKPAPPSNSAKLNTKAKSFKPQPTQVMKKIPTQKPEVKKEDKKQMVTERFEKKFQFPGPVEMKGVKARLEGGQLEIMVPKKRVMRSPGMPGMWWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBD9</accession>
    <name>U4LBD9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="2">CBS 100304</strain>
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            <dbReference type="EMBL" id="CCX07608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2319" checksum="8762F36A85BFC8E0" modified="2013-12-11" version="1">MAHHRTIGKVEHWSCNSIIV</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
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            <end position="103"/>
        </location>
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            <end position="15"/>
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            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="136" mass="15374" checksum="E989351759E86DA7" modified="2013-12-11" version="1">MAASATYATTQQSETNLRTYSRHTKQTSTAAMTQINFQRPESHKPQRNAKRVKKSAPKAKLANKNKKSIASKNSNHNTKPIVAPSHHTITPAADNLHDRGLQEQDSDYHQALLDARLRISKELGRLRMARLRRLKP</sequence>
</entry>
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    <accession>U4LDB9</accession>
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    <protein>
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        </submittedName>
    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="7086" checksum="590F231B83132C47" modified="2013-12-11" version="1">MRLDPVELLKQQSLHFNRRDNLQWSILRRRLGLEEQPITDRDCNMPSSSSWSMCAQWVL</sequence>
</entry>
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    <accession>U4LDF8</accession>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDF8"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="267" mass="31063" checksum="46BFB7DBC7A4C7A8" modified="2013-12-11" version="1">MAYQHYRPVTRARHSFTRELNPNNHQQVLAETWHKIFDYDSPAILPSARRQHFEYPDSDYEYASRGRLREYNPVVPARHPLRIDYRDTQDNHDYDHEPAVYPDPYPTTGLLSPTILCTADMPRDHPRRDELRLPRTQIPGPTPDFIKANHIGVDQINREILPLQRDKKVQPKLKMDGSFPSDFTTGLTVDEMEELDGVTLDRILIAYGLESGFSNRSRHLQEKGTNFSRFLERLILSKEGCIQLGIYPIAHMSIISHLMAIYEADKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDM7</accession>
    <name>U4LDM7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Carboxypeptidase Y inhibitor acc. no. P14306</fullName>
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        <name evidence="1" type="ORF">PCON_06293</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LDM7"/>
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    <dbReference type="OrthoDB" id="2506647at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX29632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="26243" checksum="0DA13C0089297453" modified="2013-12-11" version="1">MSLCHNILRNVNSVLLFSSLSRCGVRASISRSPRIVPQIRPLVTLNESLRETFKKHGIIPQVVDDFTPTALLSVTYPKVEVSVGNTISPEDTQDEPVIRVTPAKAKPNGDKPGEPAIYTIVLTDPDAPSRENPKNAEFCHWIQTGLTADDTIFYSKSRALMKYMGPAPPPKTGKHRYVFLLYRGSNKDLQEPKDRVRWGNPEQKKGVTVGVRKWAKEGGLELVGANFFYAQNKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDN7</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9720" checksum="CA4DF6C3FE257C7E" modified="2013-12-11" version="1">MRGIYTPGFYSIRVSQSPITSKASGDHKAPWDHVSQVSPGFGYLRSSNLESLQGIVLGSYCYIFLLHLRIRTDNSLCFCLDIQCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LET0</accession>
    <name>U4LET0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">PCON_08049</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LET0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="34475" checksum="27106F544A58DBDB" modified="2013-12-11" version="1">MDVRRRTHHRNIRGKIDDALPSNATPSSSPEKTIDSTASHAGPSSSAENPIEPTTSHEGPLSSAKLDAETMEPVEAMVSMIHINICAPVEIGGNGPRVEYLMFPISIKADDTLEKICGKIAKEFHNKMEYTWRPTQPDFWPSLPCHDIIWWFLGVQMEIYDVQFKRICQAEEEAPFRVVGPYDWEETDDVKVLPKGEPFLKWLASAIMEPFKAKEVSELELFAREMKRLAKNDALLLKLRPRPWSSRINRLSTLESEIIILTADLRSGLCGYGEDGDRSNLNRDLETGERLLIAHCTLIGYRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEX0</accession>
    <name>U4LEX0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX09987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEX0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9691" checksum="1C1750F1272451F5" modified="2013-12-11" version="1">MRTIGGFDLLLRSDDETLKPRRETRTHPVTVNLDVEPLRGISQLRSVQLSNSTKRSGWLIQISYSPPRYSRESFPPSTATNSVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFF2</accession>
    <name>U4LFF2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFF2"/>
    <dbReference type="OrthoDB" id="10375219at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="333" mass="39161" checksum="3CC6F2E1BF960B05" modified="2013-12-11" version="1">MPRDTTSCASDEENEYEERAWGEEKHSQYTPESYYSPDREPETTKHHSDYDTSTYTDSQKQRIQHRSTRNGYGTPNSNDYKMSHPQLTVDQFSLPRKEDLSTLESKPSVSISPSEVAEVQEVLINHTTKVMLQRFQQMFPIMLFLGCDVTMAKELCHKAVIINSNYTTNKIGFPRIKAIPNLTLDELTTYRDEIQDCLRWTIRRISEVELSICTAMEKFPDTPDDETEEQRDFRIALEGFMRRSIENLNLDPGHLFNRRASSKKGYIWQETNNGKPRLQQTHWAPYDRNVHCWRHAPFKHGGQGVRWIDRTDKWRPVESLRYGNIRTDERTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFL6</accession>
    <name>U4LFL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFL6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="7434" checksum="E110C2D868E8A523" modified="2013-12-11" version="1">MLYHCSFCYGRRSFGSFTAYFNLRVSLPRAPPTLKEAASYNFRPMREHEYTWKERATWYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG75</accession>
    <name>U4LG75_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized hemerythrin-like protein C869.06c acc. no. Q9URY9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX14984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG75"/>
    <dbReference type="STRING" id="1076935.U4LG75"/>
    <dbReference type="eggNOG" id="ENOG502S054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEDMFDQ"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="25345" checksum="8E30325144BF0C56" modified="2013-12-11" version="1">MLAARTIRTAARINTLTPLILARGLAASHLSSLTDAIKHDHRELETYFSNILNAKDNDTKVRWQNQLVWELSRHAVGEELVVYPAMDKYISNGTAVADKDRAAHQKVKIILQDFQAMDPSDPQFEPTLKTIIADLKQHIQDEELHDIPLLEKALANNLVESAELAKSFERTKMFTPTRSHPAAPNKPPFETAVGLMTAPMDKIRDMFAKFPREDTLGRRVPENAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG98</accession>
    <name>U4LG98_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Heat shock protein hsp9 acc. no. P50519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09529</name>
        <name evidence="3" type="ORF">PCON_09530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <strain evidence="2">CBS100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG98"/>
    <dbReference type="STRING" id="1076935.U4LG98"/>
    <dbReference type="eggNOG" id="ENOG502SDMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THTQSTM"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8643" checksum="7C7130F5DA340883" modified="2013-12-11" version="1">MSDSLRKPFSDRVSEKMTPDSSKSTIDKAKENITTTADRAVGEMQPDSSKSSTQEGFDKSRREKDTIVDKVKDAIGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGK0</accession>
    <name>U4LGK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGK0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="28" mass="2775" checksum="549312588FFBC159" modified="2013-12-11" version="1">MLILAAGPVSVPAVISKAPLPSEAGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH48</accession>
    <name>U4LH48_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protein GCY acc. no. P14065</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_09428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH48"/>
    <dbReference type="STRING" id="1076935.U4LH48"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MVNQIFL"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="319" mass="34988" checksum="FEB9C2E2E4CBB858" modified="2013-12-11" version="1">MVAPQFTLNTGAKIPALGLGTWQSPAGAVEKAVYHALTVTGLRHIDCAFAYGNEREVGAALAQVFSEGKIKREDVFITTKLWSTWHNRAEANIDESLKSLGLDYVDLYLMHWPVPMNANGNHPIMPTRPDGMRDLDEGWTWQQTWKAMEKLVEAGKAKAIGVSNFSEAYLKELLKDAKIVPAANQIENHPLLPQDGLVKFCQEHGILVTAYSPLGSTGGPLLADETVTKLAQKHGVSNGNVLINYQLKRGIAAIPKSVTPSRIDENAKTVDLTGEDIELLNGIHKAQGLKRFVSPPWPVNFLFSEANWGENFKPLLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI97</accession>
    <name>U4LI97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Positive regulator of purine utilization acc. no. P49413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI97"/>
    <dbReference type="STRING" id="1076935.U4LI97"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMILVLR"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX31257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="708" mass="77108" checksum="436FDC6AF8D0B626" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIG7</accession>
    <name>U4LIG7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIG7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9173" checksum="D14E1A18905E3C9C" modified="2013-12-11" version="1">MDSISSRTIAFPGRFAEGKVLLDSDSSRRAISCDVPLCRRGPLRKFQRLRNSGRTAFLFLEDAVRRIVVSGICTCLLSLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIJ4</accession>
    <name>U4LIJ4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">PCON_11986</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIJ4"/>
    <dbReference type="STRING" id="1076935.U4LIJ4"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="284"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="540"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="776"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="641"/>
            <end position="643"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="648"/>
            <end position="654"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119450" checksum="E31150D7C8814774" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIW5</accession>
    <name>U4LIW5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C6B12.05c acc. no. O14210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIW5"/>
    <dbReference type="STRING" id="1076935.U4LIW5"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PETWMNG"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="336"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="456" mass="49878" checksum="C458F64A4BF243E7" modified="2013-12-11" version="1">MAPQLRSPVKRRRPDYNDSDSELSDIDDIEETTPLEPEEEDDEEEDEISSDEDTPEGEVEESYLSEDAPGESDDGSDSDLKPLAKPVPSRGSGTRGRAIAKPAPKKPAPKVGPSRSRRFTASASVSVSPPPKRRPQRSRTAATRSSYQPQATKATTIKATTARAAAKSKQPTIKLKIGKDKLRQATSTWTPPPAGTDTGELLSAAGTPDSAPVSKTTMPRGRKVVQEDSEEDEDEDQEEEEDDEEDAEGEIDEEDELGDEDAEGETDDELMDSDDDTGITPGTDFLSRTGTPDMSRLTNRQRTKLGDITTADLLELPSGYETKGSAAKSVSLSVQEQELKRAEMARRRKNLTDQKLEEEKIDTINRLLKKQTPKMRGRGRATGDATPADGNGDITMGGMEAPSPPTMMRWVSNKDGIRLAIPETWMNGPIGKAYSKQEETETMRNAGTKRKLVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJG6</accession>
    <name>U4LJG6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJG6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="17622" checksum="4FEC86846096B15E" modified="2013-12-11" version="1">MAVTLELGMSTWEISKKLFNTHQKFFKSNSAFCSLLHRRLMLKDTLSLLDDYGFADFMALEAFLMKVELWAHHDEVSRSLSRRHFYIPPRCSRWVYRATGFICIAKLQIRQSRRLFLHRPRISHRDSRNHYSSENHHGNHHHRSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJX2</accession>
    <name>U4LJX2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06220</name>
        <name evidence="2" type="ORF">PCON_12589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <strain evidence="2">CBS100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF935748">
        <property type="protein sequence ID" value="CCX12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJX2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="2091" checksum="1E38D8CE5047C2C9" modified="2013-12-11" version="1">MLIDDADVLMLVQRNLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKH5</accession>
    <name>U4LKH5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKH5"/>
    <dbReference type="eggNOG" id="ENOG502QWJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTFEHTH"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53553" checksum="5AACEAC986C82C1A" modified="2013-12-11" version="1">MFSKAAGTWPSEGMTMGTRNYDLEKSSEDWTEESHRQLNQKNHGVFLRNLRYRLMSMYRRIFTLVFCVNLALLLFLSIGEKPYLAKISNASLGNLLAAVLIRNDNIINFLFRLFASMPTTWPLPIRRLGAKIYHLGGLHSGCAIFAVGWHLWLTIAMTRSASADLPVASVLSVSLCYGILVLLTLQATLAYPNLRQKHHNSFEYTHRYFGWMTVFLAWFLVLSLTRDLSQISGQSLGLALITSPAFWFLLFILMSIVSPWALTRKMPIKIQVLSRHACRIYIYDRRFAKAYPGSFVRLSTNPAGEWHSFAAIAESTENGGPGGYSVVVSNAGDWTGGMISRAFEDTPKEIWIRGVPTCGVLHVAKMFRKIVLVATGSGIGPCLAVLRAGEVEARVLWSTREPQATYGRAIVDDVLKADPQAVIYDTQKRGRPDVVKMAYGIYIQAHAEAVIIISNPALTHRVVYGLESRGIPAFGAIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKT5</accession>
    <name>U4LKT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKT5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651446" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="16074" checksum="62621E69D6AFDB51" modified="2013-12-11" version="1">MQFSSIIFTSFFAISLSLSLPEANRNATSAKLAPIRSIIGDKVQLQVCKRVAPQPDMMYASFCADMYPALETCVNLDNGAVHSMGGPMAAFDNSISHYSISGGCCRFYADFDCKNFIDAKANMRGNNPAGEGSNGKVMSLKCFKSEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMS2</accession>
    <name>U4LMS2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMS2"/>
    <dbReference type="OrthoDB" id="5407508at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="40131" checksum="A0CC53CA72AF5D51" modified="2013-12-11" version="1">MPTHRPDPFSSYRRAIRLNNPFNPLHLFLSRHPQPPNLRHGEDGQVFTETILRPLQSWSYLYEPSPIPFPVSSGIPSLSLSCRKILNIHLPSLPLEALLAIPYHPLGEAIYEDAVVTQRNTLRLWCLYSTAYPEFLRSVSYSIGEFRCGFLRELPGVDMGRWVVKLDLVTERIQGNEVRGLGELGCLVEVRLRAKDIRATEVDDGAVRGWVRARKWGRVRWVGLIGYKGITERGWGYLHSLEGLRGLELEKGVLPGKGWRAWVDKDEEMELKDQDQIPNVCEMKMDLLEFREKKKDTVIQRWVKVEMPKLEVEKKETIVATKKGPPVMRKRRMVDMGDLLGQFGPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN42</accession>
    <name>U4LN42_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to U2 small nuclear ribonucleoprotein B&amp;apos acc. no. P08579</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <end position="86"/>
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    </evidence>
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</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="300" mass="34294" checksum="CAB9F5722A811B6E" modified="2013-12-11" version="1">MDYRWGDNAELSEMEADLEKHKASLAIMAALLNAKKTVEVDAAFKKMEAQMRSSQNTAPDFKTEYEAELKMSNVYLGIRRANTIRTTSTTKSIPDMDIKRFILAEEALTPAEKRVLQPSWMGNSRIEDRYAGAGVEDIYKAIQSMPLLERISGIEEQQKKARQEHQKALEDAAELLTQDHAIRDSIQKKFAEAQAKTEAAIQMQLQHITITKDLQARNEEYRTSLEQIISERFDKQDNFLRHQRAISEGYICEAKVTSEAYTTSQRNALEVVFNAPFSEQQKELKTLHETMKDIGVANDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPF6</accession>
    <name>U4LPF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
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    </dbReference>
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    <dbReference type="OrthoDB" id="195446at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="253"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="550"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="786"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="819"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="917"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1358" mass="151878" checksum="AF4EE2176C9E63AB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQK4</accession>
    <name>U4LQK4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Vesicle transport v-SNARE protein vti1 acc. no. P78768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_05657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQK4"/>
    <dbReference type="STRING" id="1076935.U4LQK4"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEYEAND"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX29586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="218" mass="23921" checksum="4AEA098283590412" modified="2013-12-11" version="1">MDAGSELFASYEADFKLVFADITQKIDQISELTGSARKAAIQTAEKAIDEADEIITQMSLEINNIPSTSKTKPRQRLRNYSSDLDGARGSLLKLAQSTSNAAISGGNGGASDAVQMQRQQLLRGTQSLERSSQRLLDSERIARETESIGAGILGDLAVQRETIVRTHDTLHDSERYLDRSITTLRGMARRMATNRIITVAIITVLVLLIIAVIFSKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQW2</accession>
    <name>U4LQW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936512">
        <property type="protein sequence ID" value="CCX34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQW2"/>
    <dbReference type="OrthoDB" id="3662167at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="207" mass="23790" checksum="1D30AE1E642E5ECE" modified="2013-12-11" version="1">MDRSGTAADGPIKNNYSLAECFYSPPNWCGKSSWCEDTVMETNDPSVFYEDLPLYRLRLRNDPSMQFMRQVQDSKSISMFGEYSRSVTQLCLRNLSFQGDILDASAGLLRSLKSTYTPNPYPLTYYFGIPSAWFEESLCWTPFLRSKVKRRDAICRDRASGIQVPFPSWSWTGWSEVEWYKFDNRGEIIKLQIGEDPPAVPPVSNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRA5</accession>
    <name>U4LRA5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Quinate permease acc. no. P15325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_03754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="529" mass="58220" checksum="66C4757B718E7A66" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRJ9</accession>
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        </submittedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="445"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
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            <end position="336"/>
        </location>
    </feature>
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            <end position="402"/>
        </location>
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            <end position="909"/>
        </location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="223"/>
        </location>
    </feature>
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            <end position="240"/>
        </location>
    </feature>
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        </location>
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            <end position="891"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115414" checksum="781EE36B32631E4E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRU2</accession>
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        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936600">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRU2"/>
    <dbReference type="STRING" id="1076935.U4LRU2"/>
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    </dbReference>
    <dbReference type="OMA" id="QNMSGDP"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="152"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="491"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="856" mass="96861" checksum="72BFEF0864451607" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRZ9</accession>
    <name>U4LRZ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRZ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3377" checksum="A1A1A7D981C7F556" modified="2013-12-11" version="1">MIQPILLISKLCYATSNKPVNLLPKHNTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSA9</accession>
    <name>U4LSA9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSA9"/>
    <dbReference type="STRING" id="1076935.U4LSA9"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYSEPQT"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="422" mass="44304" checksum="78946FE12BCDF087" modified="2013-12-11" version="1">MLFSRTMSRLGTALPAHLRIGICPSTAVHTLSSPLAPLTFHRPLTSGTSSSSSSSSSSSSSSSAGSASSMNSSPSTPTSSESEAGPASPVSPAPTEAADEQRFRYNIAASFSPKGKKYEPERDVYKHTKLSPAYPSPTDLRSTAGQDAFFVAGIERWEGARALGVVGVGGYDSEGIDSAFFSQALCSRMAIAAKGALSEDVNPKALLNVGYKRVLDEDVIKGGASTACVAVLTQKGQMAVANLGDSGFVVLRAGKLVYASQAQTHSFNCPLQLAMIPRRMRELYGPMSDSPNDAHLSCHTMQHGDIVIFATDGVWDNVTNQDILRTVTSEMTASGAWAIEEGKGITATITAGPGIEGVAEKIAKALVAKAKSLSTNNKIDGPFAKEVQRLFPNETYRGGKVDDITVLVVGVRELALEAVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSY3</accession>
    <name>U4LSY3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Vacuolar protein-sorting-associated protein 46 acc. no. O60074</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSY3"/>
    <dbReference type="STRING" id="1076935.U4LSY3"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="195" mass="21582" checksum="7D4766955FEE53BB" modified="2013-12-11" version="1">MSGLENSLIQLKVTAKELTRKAAKAAKEETAEKAKIKKAMMQGNNDIAKLYADNAIRKQKERLQLLQLASKIDAVASRIQTAVTMRRVAGDMAKVVKKMEVTAGRFNPENISKVMEQFEMHQEELDVTMRVYENTTSSATAVSTPQEDVDRLLSQVADEAGLEMHQALPTAAKAKIGPTEQEENGLNERLRALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTL3</accession>
    <name>U4LTL3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to SWI/SNF and RSC complexes subunit ssr3 acc. no. Q9P7S3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTL3"/>
    <dbReference type="STRING" id="1076935.U4LTL3"/>
    <dbReference type="eggNOG" id="KOG2570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="4">
        <location>
            <begin position="558"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="774" mass="88042" checksum="A721CF41328F9D8F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTP3</accession>
    <name>U4LTP3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C3H8.05c acc. no. Q10141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LTP3"/>
    <dbReference type="eggNOG" id="ENOG502QVPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARDHPRC"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="2">
        <location>
            <begin position="42"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1341" mass="148162" checksum="031BA42A6468EB78" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTU0</accession>
    <name>U4LTU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTU0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="9783" checksum="C1C6971AECE45F96" modified="2013-12-11" version="1">MFEMPTMPIGSSTFRFNGNLRLIAASVSTRLPPILHEVSAEKLPPVSLAPTDGSHNSPHAFSNVINLKDLWSQVTGPTYICCFIRNQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU30</accession>
    <name>U4LU30_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU30"/>
    <dbReference type="STRING" id="1076935.U4LU30"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMPWGWG"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="275" mass="30832" checksum="D07DE2FCF0611AD4" modified="2013-12-11" version="1">MFDLFAKLLCSVATFAFPVFASYKALKSNDPSQLTPWVIYWVVMSCVFFVESWVGWAISWFPFYQDIRAIFMLWLVLPQTQGATKLYFEYIHPQLAEHEIQIEEFIAKSHEQAKAAGAEYIQRLLESAKAAVFGGLANDGRPMTPVPTDAAGYAQHLFNRWKVPQIGNAPQLASDLYSFMSTALNQPTQGQGADKGPTNLIPAHVKTQQEKQRFIELQRERLKTVMAALESEMEGLEEPKLPKSMSQGNISVAGDFEKVSLSDADSDNGWGRKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU40</accession>
    <name>U4LU40_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized RNA-binding protein C126.11c acc. no. O94403</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU40"/>
    <dbReference type="STRING" id="1076935.U4LU40"/>
    <dbReference type="eggNOG" id="ENOG502SBWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSKMNIR"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="207"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="346" mass="37007" checksum="7D194E6718C9C26A" modified="2013-12-11" version="1">MPRNPNLTLDQFLDEKRRAEASKTASAILGKARFGASGKGAITPTRNTTPASRSPTSATKSRIQKSTSIPGLPVSQQTARSLAGNKLFTALHPDAVRVVPSPPAGPSVSSTPSGPKHGNGGRLSRPGSKRPSPVRAMGGNGGNNGRSNQNQNNGGQQANRGNNSQNNNQSNNGQNNNQSNGAQNSKMNIRGSAPANQMTIKGAAGPAVLQASNFAPGTTAEDIRHHMSTFGNVKSCLVLTAYPTVIAEIVFETMQQGKDVVERFNGVWADGRMLSVTFKTTPPIANLSHLTNPQPIPDPFKEREEADRRRREQNIHYQDGTYGVQAPPIYSDDLLRKGRGRFNMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUQ7</accession>
    <name>U4LUQ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Vacuolar ATPase assembly integral membrane protein vph2 acc. no. O74920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUQ7"/>
    <dbReference type="STRING" id="1076935.U4LUQ7"/>
    <dbReference type="eggNOG" id="ENOG502RXKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWYATAN"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="207" mass="22752" checksum="64597F850898BD53" modified="2013-12-11" version="1">MVLLTTTPRIHSALTAYNALPSVDSPLSAEECITHTDLRLISQSLISRSSDYSYAALLRGSSVYTPPPPPPPPKTPEYIALMKRLRQEAEEREYRGLTTEAEEVVEEEMTWKEVKSQISVIFNVMLSVFATAAAVWKVAESWDAPERLAAAFASAILVGVAEVVLFMGYVRRLDQGKKVEGKKKDVASIKAVWEVGVDGVKARVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV72</accession>
    <name>U4LV72_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_03523</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="HF936516">
        <property type="protein sequence ID" value="CCX34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV72"/>
    <dbReference type="STRING" id="1076935.U4LV72"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DNLWTEP"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="320" mass="35000" checksum="1234DD5463B2808C" modified="2013-12-11" version="1">MSSNSIKLLTGNSHPALAQRVAERLGVELLDMSVFKYSNQETSVIMRESVRDEDVFILQTTCPGDNLNDHLMELLIIVKACKTASARRITAIMPNFPYARQDKKDKSRAPISAKLIANMIQRAGCDHVITLDLHASQIQGFFDVPVDNLYAEPLTLRYIRENFDYKNAVIVSPDAGGAKRATALADRLDLNFALIHKERSRPNEVSRMTLVGEVEGKIAILVDDMADTCGTLCKAADVLMAGGAKEVVAIVTHAILSGDAAEKVSASKLSRLVVTDTVPHDDKKKRCAKIDTIDVAPTIAEACRRTHNGESVSFLFSHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW78</accession>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        </location>
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        <source>
            <dbReference type="EMBL" id="CCX33321.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="5001" checksum="ACA2B8EFF00E2492" modified="2013-12-11" version="1">MSLGIKCIEKKLEAITEGELENLVQWISPNEAMKRHHNIVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWZ1</accession>
    <name>U4LWZ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="16034" checksum="659C2D107771AA6D" modified="2013-12-11" version="1">MAMACYDFHDCSSIYLLILIKLVALIIFPGFIIWTWPSDTVFVGDARFLGRPDDEISRRVDRDPWPHPPPPPQQEEQHQTSHTILDWLVYFLVHVFIPFFGVLTVLCFPLLIMRFEPDDPPEILSGHWQREQGSGSGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUB6</accession>
    <name>U4KUB6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03850</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX04868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4KUB6"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DLPMNMS"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="14851" checksum="F4857524874B34A1" modified="2013-12-11" version="1">MTDIPRIPEDIEGGNLDLPVTLSASVLLTSLPRDGQRALQKAAHPTPTKVTIKFKAMGSAPMLNKDTYKIKTSQRFENVAVFLRSQLGIGPADSLFLYINFTFAPALDENVGNLWNCFKTGEELIINYSMQSAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUG2</accession>
    <name>U4KUG2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935200">
        <property type="protein sequence ID" value="CCX04371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUG2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="10570" checksum="DDB4B320584B3A23" modified="2013-12-11" version="1">MDHRFRYLNEGRELILQAAPSIDSMRSRMIIFHDASHLMKIEEVEKVEDQHQRPPPSCWKQRGQIILTEPVDMYLRASLPRGKIKEYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW34</accession>
    <name>U4KW34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW34"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="273" mass="30688" checksum="777769C8F8C54425" modified="2013-12-11" version="1">MNSSAIADIIENNYSSDTAVTNRNDGYSSDYDADDESDKYSPQSPQRVVRRTRSSNNKPFKAAKGKKTSSSIWINLEDEDADTTGPTPMTERVNQKEHKEMGRLGERKRSQDEGTDNSSHSSTEKRSICSSKTSKTEPMDNETMTTTWRPEDEPLGAVLTCSSVQLRKIIQILCHLRDMCSGSCDDDASKIEYQTEIQRIIDFLNIRAAGNNVGARAGRYNYIGDAPNHTDHLKEIMVILKETDPQKRLADLFNYELYLKRQKALQVKGMGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWS8</accession>
    <name>U4KWS8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Ketohexokinase acc. no. P50053</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWS8"/>
    <dbReference type="STRING" id="1076935.U4KWS8"/>
    <dbReference type="eggNOG" id="KOG2947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="347" mass="38413" checksum="391EB7E8C3EF11E8" modified="2013-12-11" version="1">MTDPRPGILFIGAIYEDTLLYVPSLKEDRKTRLTSKDVRIGGNVINTLKVLQSAPAFDYSSDSAFSHLYYFGAVGNKNSCSDVYADLREHNIEPTLFHREDCKGIDEAIVICSEESNTRTILSHTKNISEPTALELTTAFFALPVTPYWIHIEGRNCIEVLKFLKVIRSVGFIGKISVDLERDREGSKELIAEANILFVSHTYGEALIKESIEEQINDSIKVLDPSEIAAQITEILCLEMKLDACLYILWGKYGSFGFVHNENFASGDSLKMYEGFLATYYPGKKALVHSLAYPSKIVETVGAGDSYIAGALWTHARSHAMSPHVDPYSDSDYPSPLTMATSVGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWU0</accession>
    <name>U4KWU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to UBA domain-containing protein 14 acc. no. Q9UTK7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_05708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWU0"/>
    <dbReference type="STRING" id="1076935.U4KWU0"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYRQFWR"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651146" evidence="6">
        <location>
            <begin position="31"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="255" mass="28372" checksum="3963F10C5195514B" modified="2013-12-11" version="1">MQQTGFTSTPITRSLLYALLSSSLLSSLTSIKPSFHLQVVPHLFPQHQFFRLLSFQSIYANSGELLFGLLLLYNLRQIERLFGSRKFLSLLLYTYAATSVITPTLLLAGWMATKGRWNYLPPGPTPLLFAILAQYHAAVPGTYKFSLLLPGGAGEIEGSDKIYSYLLAVQLAACQLPGSLVGAAVGWVVGYAWRLDLLPKTRWRVGRGIVRMLGGDVEGKEYEALRRRLREGETEQSQAAERPIVSRVFGQFMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWY5</accession>
    <name>U4KWY5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">PCON_06064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWY5"/>
    <dbReference type="STRING" id="1076935.U4KWY5"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX06477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="258" mass="28384" checksum="4123B050085293AA" modified="2013-12-11" version="1">MAPTVADITGLKDLVNQLQDRITKIEKSMKGEDATWDADRIRMILMGPPGAGKGTQAPKIKEKFCACHLATGDMLRSQVAAKTPLGLAAKKIMNEGGLVSDEIVIGMIQSELDNNPECKNGFILDGFPRTVPQAEGLDKMLANRGDKLDHAIQLEIDDALLVARITGRLVHPASGRSYHRIFNPPKDDMKDDVTGEPLIQRSDDNADALKKRLVTYHSQTTPVVGYYQKQGIWRGIDASQEPGQVWKALLAVFNEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXW7</accession>
    <name>U4KXW7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Inhibitory regulator protein BUD2/CLA2 acc. no. P33314</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935312">
        <property type="protein sequence ID" value="CCX06771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXW7"/>
    <dbReference type="STRING" id="1076935.U4KXW7"/>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKDWTLI"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="637"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="831"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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            <end position="83"/>
        </location>
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            <begin position="103"/>
            <end position="196"/>
        </location>
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        </location>
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            <end position="499"/>
        </location>
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        </location>
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            <begin position="11"/>
            <end position="30"/>
        </location>
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        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
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        </location>
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            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX06771.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1261" mass="139470" checksum="5BF56FDEF8051BE3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYE1</accession>
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        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">PCON_03055</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
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        <subcellularLocation>
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    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
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    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_III_sf"/>
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    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
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            <end position="443"/>
        </location>
    </feature>
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        <location>
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            <end position="80"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
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            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="745"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="745" mass="82216" checksum="4F9383AF5780A195" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ71</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06940</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07351.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ71"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="2074" checksum="8ABCA53D8B4E7A61" modified="2013-12-11" version="1">MFCTISTTPKPLEFFNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L056</accession>
    <name>U4L056_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_04951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L056"/>
    <dbReference type="STRING" id="1076935.U4L056"/>
    <dbReference type="eggNOG" id="KOG2828">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCIVPMV"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX05364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="529" mass="58043" checksum="1E3ED0AFE9084AAC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4L091</accession>
    <name>U4L091_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to Probable cation-transporting ATPase 1 acc. no. P39986</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_07183</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L091"/>
    <dbReference type="STRING" id="1076935.U4L091"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1084"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="261"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1262" mass="140266" checksum="0260B05A6476D707" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0B2</accession>
    <name>U4L0B2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Uncharacterized MFS-type transporter PB1E7.08c acc. no. Q9C101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_05021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0B2"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LLWFIWM"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="73"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX05434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="528" mass="57020" checksum="DD81A2C7E593C227" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0P2</accession>
    <name>U4L0P2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0P2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7369" checksum="798AAFD4020566B3" modified="2013-12-11" version="1">MSAFRGGDKAPIKSVLSNFWAQCESQPLLVFETEQIGGHNCTCCGQIDEVSERHLRVLNGFGNKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0P3</accession>
    <name>U4L0P3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Myosin type-2 heavy chain 1 acc. no. Q9USI6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_05196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L0P3"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DVRFLHK"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
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            <end position="889"/>
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        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
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            <end position="1672"/>
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        <location>
            <begin position="1749"/>
            <end position="1830"/>
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        <location>
            <begin position="1860"/>
            <end position="1922"/>
        </location>
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            <end position="2084"/>
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        <location>
            <begin position="2120"/>
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        <location>
            <begin position="2225"/>
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        <location>
            <begin position="39"/>
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        </location>
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        <location>
            <begin position="297"/>
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        </location>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX05609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2425" mass="279450" checksum="D0C1F0DE26CFA277" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0W1</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX09267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10356" checksum="7B75156C47F0B44C" modified="2013-12-11" version="1">MIICRTGSTHIHAHKYAHIFSYIDSLFSFYAHKSLLRTQCTDRSKNPSTRSAFADAVVPRSAPVPRAADVEVVLPATTIWTRNKRMTRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1F1</accession>
    <name>U4L1F1_PYROM</name>
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        <submittedName>
            <fullName evidence="6">Similar to Probable disulfide bond reductase yfcG acc. no. P77526</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <text evidence="1 2">Belongs to the GST superfamily.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="122"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="273" mass="30914" checksum="7A1740C86232FB9B" modified="2013-12-11" version="1">MASTLANRTKLITRHLTTAAKSIMSDAKHPITLYTAQTPNGVKVSILLEELGLPYNVRTISFDKTEQKEPWFLEINPNGRIPALTDSSFDNGKGINLMESGCILQYLVETYDKDHKISYPHGTAEYWDVQQWVYFQNAGVGPMQGQANHFYRYAPEKIPYGINRYQTETARLYGVLNTRLEQQAKKGSGFLVGDKLTIADITTYGWVRSAGWAGIDIENFPALKKWEELLDEREGFKKGRDVPTPSRIKEMAKDEEAAKREAAKASAWIMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L202</accession>
    <name>U4L202_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06283.1"/>
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    <dbReference type="OrthoDB" id="3353407at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="575" mass="64528" checksum="50EFB733BBB1D80C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L219</accession>
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        <submittedName>
            <fullName evidence="6">Similar to Cleavage stimulation factor subunit 2 acc. no. Q8HXM1</fullName>
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        <name evidence="6" type="ORF">PCON_08494</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935436">
        <property type="protein sequence ID" value="CCX08901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L219"/>
    <dbReference type="STRING" id="1076935.U4L219"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX08901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="278" mass="30274" checksum="62884F868F44279F" modified="2013-12-11" version="1">MPSDARAAGKIVFVGNIPYGLTEEQIAEIFSSAGRVISFRLVYDRETGRPKGFGFAEYSDAETAASAVRNLDNYEIMGRKLRVDFSHEGNAPDDVDTASYSQQPQQNQATLPSGTDMPEGISAPDAISNTLKALPVPQLLEILQQMKTLVNQDPVKATDLLRQAPQLSYAIFQALLLMNLVDTTVLTQVIETSGGTAPPPQPVQQQPPVQQQQPPQQYYQPPAATPTPPVPAPAVDPQRAQLMQSVLHLTPEQIASFPPEQQQQILFLKQQYMAGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Y6</accession>
    <name>U4L2Y6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935302">
        <property type="protein sequence ID" value="CCX06618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2Y6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="97" mass="11066" checksum="5A909EED90D3EDBA" modified="2013-12-11" version="1">MTTPVRGYTTEKKVVLSNRPNGTIRRNFSKNSSPTNALDVSRSIMPLRKTSNIKLAVKKEEVQDNRGDPMDMDIDMQEVEYDDPKRCDGDIIMKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Z8</accession>
    <name>U4L2Z8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to TPR and ankyrin repeat-containing protein 1 acc. no. Q8BV79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935568">
        <property type="protein sequence ID" value="CCX10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L2Z8"/>
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    </dbReference>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1343" mass="153109" checksum="DC573EC5D87D6625" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L304</accession>
    <name>U4L304_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Succinate dehydrogenase cytochrome B subunit, mitochondrial acc. no. O74882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="GOC"/>
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        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
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        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
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        <property type="entry name" value="SQR/QFR_C/D"/>
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        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
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        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
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        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
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        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX09740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="179" mass="19321" checksum="4D643A48520534E6" modified="2013-12-11" version="1">MSLSRSSIRAAAKFSVRPSALLLPRAAVCQTRSAATTTKTSDAEAYSLLVEQRKKRPIAPHLSIYEPQLTWYMSAANRVTGVALAGSFYLFGISYALSPYIGFHVESAAIAGAFATLPLAAKMAVKATFATPFVYHSMNGLRHLTWDTARQLTIKGVYRTGYAVLAATAVGSVYLSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L322</accession>
    <name>U4L322_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCON_10461</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 100304</strain>
            <tissue evidence="24">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L322"/>
    <dbReference type="STRING" id="1076935.U4L322"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="218"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="754"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1017"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCX10867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1165" mass="127669" checksum="DC03B46BDB33A43A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L337</accession>
    <name>U4L337_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Serine/threonine-protein kinase PRR1 acc. no. P28708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L337"/>
    <dbReference type="STRING" id="1076935.U4L337"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFMSIGR"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="461"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
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            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="791" mass="86067" checksum="469153EB7450E6C8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L419</accession>
    <name>U4L419_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L419"/>
    <dbReference type="STRING" id="1076935.U4L419"/>
    <dbReference type="eggNOG" id="ENOG502QV8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMTEDDC"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651095" description="Membrane anchor Opy2 N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="49587" checksum="09AF0076538F4A54" modified="2013-12-11" version="1">MALLRYLSVRAILLALVLNVILAHGAATAGPGSLIFARQNPGCITGCPALPACQCNDNQRCELTAQTCGACAEVKCVDIVRPKEKFSGGAIAGACLGGLVGATIFSFVVWKFCGKKRKRSSLGASAAEKENDFGMLKSARASTHTVASIASTVRTRASNVIQIAYIPGVTNRSNPNSPGHLVPPVPPITYADSPTGSQFPRTPHIDIQFAADDLVRNSVYTVDNRSSIATTIYGGNAIVHTVQQPTMIRAGRAAVVTVKAGSVATNSSDNSPTPGSRDSIPPVPALFTTAGPAIAQRKPTTIVTTAEESTTATPPSPTFSIGANFLNRVNTKEADAAANQKKSKPIPENTSTQFDSDSDDDDENDELVPGHRGERNSVAESCITAMDPCSPFSDDNIAEALPAVAMIREEPRQEEDLNKKEAVEAAKRRSRQLEAEKRESRVILMARQIERTNSPFDDSNAIDKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4J8</accession>
    <name>U4L4J8_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Rab guanine nucleotide exchange factor sec2 acc. no. O13930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04090</name>
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    <organism evidence="4 5">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4L4J8"/>
    <dbReference type="STRING" id="1076935.U4L4J8"/>
    <dbReference type="eggNOG" id="KOG4324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CCEFTGY"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="74"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="712" mass="79029" checksum="167CE39A96C39F02" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4L1</accession>
    <name>U4L4L1_PYROM</name>
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        <recommendedName>
            <fullName evidence="3 6">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11596</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cut8/STS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX12002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L4L1"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00016204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="291" mass="33025" checksum="B862D19007491D5A" modified="2013-12-11" version="1">MSTLMNPQPFPLHNSPMHSRPRAGGKKRKAEDEPLTEPRSYDSDMDHQMMSPIPQARIIKKPRSNVVSGRPLPLSRLLENVDSETVKNILKTVVDRHPELLKEVTELAPRPTPQSALTTLQNYEKAYRHAFPYGGNVQSDYHHNRVRPALNYLLDALSDYTPHFLPPHEAQHSVSLEFLDGATQIIQRLPEWDNPLHNVSKQTAYEEIAKAWILVIEESGKKGAGITLQYGGWDTKIAKHNQDSGGRLESVVQAIRQTLQYGGMQEQQRQTQRTGLGYSWNTQQNSGLRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4S4</accession>
    <name>U4L4S4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4S4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8814" checksum="066B87EA615D37CB" modified="2013-12-11" version="1">MTYPEFLILATSELILPYTEARPGIRREDGGLNGRKEDKLKEGGLDGRIRRENRQEEGGFIERIGWEDWFYHSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5E5</accession>
    <name>U4L5E5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Tuberous sclerosis 2 protein homolog acc. no. Q9UUG9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L5E5"/>
    <dbReference type="eggNOG" id="KOG3687">
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    </dbReference>
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    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1543"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1607" mass="180535" checksum="43F32BBEFD2AC0C9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5L4</accession>
    <name>U4L5L4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5L4"/>
    <dbReference type="STRING" id="1076935.U4L5L4"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIKWNEG"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="596" mass="67543" checksum="2E7446F6C06A4A54" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5M2</accession>
    <name>U4L5M2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935700">
        <property type="protein sequence ID" value="CCX12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5M2"/>
    <dbReference type="STRING" id="1076935.U4L5M2"/>
    <dbReference type="eggNOG" id="KOG0423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="360" mass="39645" checksum="905F8B2B8E2D6354" modified="2013-12-11" version="1">MASNLARRRLARDHAALRESLPPDFFFAGEPSDDLRGVTVHLAGPTSTPYEPGVFAIILRIPDTYPVDPPKANFQTKIYHPNVDMRTGDVCVETLKRDWKPTLTLKDVLSTIRCLLVYPNPDSSLNEEAGKMLQEGYNVFQKHARMMTEVYARVPEELQKLVMETRARRAEDDDEPAPAAPAQAPAAPAAEPMRLQATPARNNAATACATPPRLGSKPRAPVITRRTATGKPRTVMSAGAGQAVLDGHHDDSDDADSGKENAVRRTTRRRSSSGQKRGRDMMDIDIPEGSTAASAALGSEFLEEMRKSPRLEGFDQFMGVSHVKEEPVIQLPNKIVVPRKKMPGNKQVKKPGLRLGLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6S3</accession>
    <name>U4L6S3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Nucleoporin nup120 acc. no. O43044</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6S3"/>
    <dbReference type="STRING" id="1076935.U4L6S3"/>
    <dbReference type="eggNOG" id="ENOG502QQWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TLWKNNM"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="80"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="6">
        <location>
            <begin position="659"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="7">
        <location>
            <begin position="879"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX13114.1"/>
        </source>
    </evidence>
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        <source>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936517">
        <property type="protein sequence ID" value="CCX16790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB97"/>
    <dbReference type="STRING" id="1076935.U4LB97"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIHYVTD"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11254" checksum="2F0DF11B92E92807" modified="2013-12-11" version="1">MVTVIANKAEFDAAIAQDKLVVLDMHATWCGPCKQVAPKIEALSKEETNVAFYKIDVDEVPDVASELGVRAMPTFYFYREGVKVAEVVGANIRAVTAAVADHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBH4</accession>
    <name>U4LBH4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_04428</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBH4"/>
    <dbReference type="STRING" id="1076935.U4LBH4"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="31"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="392"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX17424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="517" mass="56969" checksum="C11F57A5898CF968" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBJ0</accession>
    <name>U4LBJ0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">beta-glucosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBJ0"/>
    <dbReference type="STRING" id="1076935.U4LBJ0"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YYPSPWA"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651836" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="775"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="853" mass="93182" checksum="543A9FF47E866FD3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCT5</accession>
    <name>U4LCT5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCT5"/>
    <dbReference type="eggNOG" id="ENOG502RR25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRTHINF"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="46236" checksum="11432E2D14438FB2" modified="2013-12-11" version="1">MPLHLLHHKSYHVYNAANIARVRRDEAEAEAAAASAAEHAASNASRDRLEILRARAAGIEPPPKPLLPDQDDETEKDPDHPRPKKKLRTDAQRRLDLHVDKAGLTDEAGHINLFPTLPEKTRKNEEAEKERKEKEALWEARTFQNALGRPCDDLTPWYTKAGDKGDNEEAEGDNGGDKRTEWKQKKEVMRKDWADPMRIVETGVRKLKEVEETREEWRRTREREVGGAEMTEARESRRRRDIRHDKEASPVPVSSSHTKESQGHGNAKRESHTNKTKDRHRHRRRSRSRSRSPKGRDHHHRKRDRRSRSRSRSRSRQHSDERHKRRHHSHRSDTRRQKDSTDNDKLTKLRAEREKREASERAKAEQLLRKEEERNTPGWKPVEGGRYSKQYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCZ1</accession>
    <name>U4LCZ1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_03880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936562">
        <property type="protein sequence ID" value="CCX16991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCZ1"/>
    <dbReference type="STRING" id="1076935.U4LCZ1"/>
    <dbReference type="eggNOG" id="KOG0458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRMAISE"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
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            <dbReference type="ARBA" id="ARBA00074866"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX16991.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    <sequence length="816" mass="87552" checksum="534B2B0D4CC5CD8E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17743" checksum="E5CF01E67F67255F" modified="2013-12-11" version="1">MFGRTEHIIRDDGIPAADLQKLQMLPIANPHPSTRALIEDVQNTMNIVRAIHTKDLKDPDVPKLYEVLQKALVRSFDDKKSEQIVQLWQKYNEQNTTPATAPKKGGWFGGKESEDLELLLTARARGNDGSLAFWAHRALKESKVARYTEDSRRDGY</sequence>
</entry>
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        <submittedName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom_sf"/>
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    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
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        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="412"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="911" mass="98334" checksum="AC4AAF1BB818A2CC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDH4</accession>
    <name>U4LDH4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to PCI domain-containing protein C1105.07c acc. no. Q9Y820</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LDH4"/>
    <dbReference type="STRING" id="1076935.U4LDH4"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="524" mass="60080" checksum="7344BFC3FE2A8165" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDH6</accession>
    <name>U4LDH6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_05653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDH6"/>
    <dbReference type="STRING" id="1076935.U4LDH6"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YKLMGED"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX29582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="264" mass="29528" checksum="853B0AE45A5E35BD" modified="2013-12-11" version="1">MSFQLGPSDSDSESELPFPAPLAQDAFSITHADFSPHEFLASLRNRHQTLEDLRTELRTRSRDLESELVELVNRDYADFVGLGSSVKGGEARVEDLKVGLLGFRREVETVIKNVERTRVEVKKELAIKEGIRKEKVLVRNLLALAQRLDELSALLLLDGASTGPPGFLEDGESLTSTRRLRKLVAAYVYVVEFLLPKVPSQHPFVKAQQPRMTKIKDTLLIDLRSALREARQEKDGEKILELIKLFADLGAESVAVKALKGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDJ4</accession>
    <name>U4LDJ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDJ4"/>
    <dbReference type="STRING" id="1076935.U4LDJ4"/>
    <dbReference type="eggNOG" id="ENOG502T0TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HGNFAQR"/>
    <dbReference type="OrthoDB" id="5402816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="6885" checksum="0A9FB19C08250798" modified="2013-12-11" version="1">MPAIETTHLIKRAEELVKRSGHGNFAQREPGVILVFCILGAIAILLISLKIYKKASERAAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDK2</accession>
    <name>U4LDK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDK2"/>
    <dbReference type="OrthoDB" id="10289495at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="292" mass="33230" checksum="60D0F011638A82F9" modified="2013-12-11" version="1">MADISMTPQNYAVEVDVWPNSSLLQDAGITSLPVFGSLDDANRAASVLRKGIESHLDRIIGPTNSEFYKKLPLHVWQPIANFCSLQPDRIGPFYSLRYKDDLAPRRVYTSLLGRYWPDNDAMIPWQIRVVPTPYPVNSPGPSWITAGENLVNSLTRISLERLYNEKYPSALHRARDPDTNTGGTVRLVQPSFDSVRQMLMVDLIIFVFTLGPYIDLAKIITKEKFNNSANWPAKPCLDTVINDTLLEMERQKSIQEETEIERNSPKKSSSTWKNLRRMLSRKNSKSSHHIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE05</accession>
    <name>U4LE05_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to similar to sister chromatid cohesion protein Dcc1 [Leptosphaeria maculans JN3] acc. no. CBX94006</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE05"/>
    <dbReference type="STRING" id="1076935.U4LE05"/>
    <dbReference type="eggNOG" id="ENOG502SA0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HDYVNLC"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="365" mass="38960" checksum="3346DEDD774C8510" modified="2013-12-11" version="1">MSDSTTKVSFTISQTQAPLRLIELPSAILSLIQSDNPPTVYIKSSPPLPPNERSTSTADHAVLCTPTATYALRQVHSSNITYLITPSSNPNTPIPDDTLTDFPNAEVGLSTVTAISSVTSHLEPLPHTPDTSSLLLPHLLPFPTPPTTSGNHGNHGKSKSWILSNIPAHATAINSAFASLVVFETSGSCYLPSPAILLRTMKEILTTADAERIVLCPSPPLSPQPFGLQKLLDSIFEDGPMADIPGELVGAVVRVIADGDGSGGWVFNRERAVEMVGRWVLAEKGNMVTAAFLRMWREHLPEGCEGLCKIEGAKWCEKSGGLVGLVGGPTPGAAAAGAPGVEKKVEEKPVTTKNKWHEKFRKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEJ4</accession>
    <name>U4LEJ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935395">
        <property type="protein sequence ID" value="CCX29972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEJ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3723" checksum="9055E38DCEAD900C" modified="2013-12-11" version="1">MHNGRWDENDGIKLGTGLGNAMDGVECYVSNYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEN5</accession>
    <name>U4LEN5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Zinc finger protein C1039.05c acc. no. Q9US36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEN5"/>
    <dbReference type="STRING" id="1076935.U4LEN5"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THLHAAF"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="346"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX13200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="910" mass="100561" checksum="56F711EA55C4CFCD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFE4</accession>
    <name>U4LFE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Ribosomal RNA-processing protein 12 acc. no. Q12754</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935524">
        <property type="protein sequence ID" value="CCX10222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFE4"/>
    <dbReference type="STRING" id="1076935.U4LFE4"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PDQMKHR"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="15"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="338"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX10222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1237" mass="136547" checksum="3E816A06A14C520A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFU5</accession>
    <name>U4LFU5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFU5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6636" checksum="AFDD3BDCDBE6C937" modified="2013-12-11" version="1">MDMALDTSDTLNGQPGWMVYLFKGSEMIELLNGLLLTLPLILLLWACLKQAIELPSSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFX6</accession>
    <name>U4LFX6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Protein HMF1 acc. no. P40037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFX6"/>
    <dbReference type="STRING" id="1076935.U4LFX6"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFLTEFK"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="123" mass="13271" checksum="170939E3752F898C" modified="2013-12-11" version="1">MKANGMVFVSGQIPADKEGNIITGSIEEVTEAVFANLAAVLKASGSSFNRVVKVNVFLSDMGNFARMNSVYEKYFSGHKPARSCVAVKELPKGVDVEIECIALEDTTPGKTIGRQHGEDDEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG54</accession>
    <name>U4LG54_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_08721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG54"/>
    <dbReference type="eggNOG" id="KOG1803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIIHGPP"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="258"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX30522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="725" mass="79756" checksum="B8318EA224E356FC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGP0</accession>
    <name>U4LGP0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to WD repeat-containing protein mip1 acc. no. P87141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LGP0"/>
    <dbReference type="eggNOG" id="KOG1517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TEVCTND"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH66</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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        <location>
            <begin position="20"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH83</accession>
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    </protein>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
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                <person name="Altegoer F."/>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
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    </comment>
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        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
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        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
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        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
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        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
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        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
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        <property type="entry name" value="GluRS_core"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="32"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="421"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX31273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="544" mass="61814" checksum="CD22BAFBE5EAA98B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHF3</accession>
    <name>U4LHF3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHF3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8631" checksum="A53319039A61DC48" modified="2013-12-11" version="1">MNNQTPQSTSTASSQTPTPPNPPGCNCASCTCQPTCDCCIPTCDDKHQEAKPDSDWVLSDEDAARYDRLFWAFWGSWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHK3</accession>
    <name>U4LHK3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHK3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651373" evidence="2">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11402" checksum="332A49FC0C496E7C" modified="2013-12-11" version="1">MSLRLFGKFSAPRGPLIFALFIAFILYSFLPAEVEAAFSWKGKTTCEAWKDAGDINEFNDCIRSSQNTGKMWGIGVGAVFGFALLCLAIHQLWSFLRYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHT9</accession>
    <name>U4LHT9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHT9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="271" mass="31762" checksum="6A70C9AFD827F419" modified="2013-12-11" version="1">MNLLKNVRLAVEFVPPPNKPFSKTFFLSQHHQLWGSRQAGAPFFRTSASAPEHHRHYRQRRNQKMQSPITPRRITAEDALRFTFEKLHRMHSEEYQSVILSMSLHPATPVAPRHPRDIDTRHLQEIFINDHDNQNTACPQLSFPAVPGFAVARHPRDVPTPEMKLILKAFSCKYPKIASDNNIMELMEVVEGFEREKERREKEVKERGKVGEWRYRVGEKIRGVIERVPDRRRGGPGGFGIERKVSLVSNQHHQQHQGRMQKIRGWVRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHW3</accession>
    <name>U4LHW3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="13" mass="1411" checksum="85046F6AF3E8A045" modified="2013-12-11" version="1">MAGIRSITFTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI81</accession>
    <name>U4LI81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 37S ribosomal protein MRP21, mitochondrial acc. no. P38175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI81"/>
    <dbReference type="STRING" id="1076935.U4LI81"/>
    <dbReference type="eggNOG" id="ENOG502SYGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HERWIKR"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX16401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="168" mass="18768" checksum="D891B5D3AEDFA916" modified="2013-12-11" version="1">MEFRRVIGAAAAARPVQSLFPRTVRTFSTTVRRAADEGKPATKTPHPYSILDAFSSGSQAPRHRAAGTGGMFGRNTMPIAQVLQSKPPKMGPTAGRSVVVTADVAQAFMRLRSILSQNRVQKDVYSQRFHERPGLKRKRLASERHRRRFKEGFKRMVSIVMDMKAKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI92</accession>
    <name>U4LI92_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI92"/>
    <dbReference type="OrthoDB" id="5505746at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19795" checksum="346FF61C5AF4B9FD" modified="2013-12-11" version="1">MQALNLYMYVMLHFAPADVQVPLALAFFNYTYHLYDLFKRNTFSSVLLYHFNFHNMRLQKDAYDPVGWDAAEISRFHILHPNQRTAQDPFASEHKAKSQATGSKPYGRAMPTCTKYNKGECSHKNCKYPHVCSYCMYPSHTVQQCNKKRQAKGMTSNIRVQGSANGANATSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIH8</accession>
    <name>U4LIH8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIH8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="13677" checksum="197EA55BA2045C77" modified="2013-12-11" version="1">MPPVVGVPEGVSKGVTLTIAVFSKEGETPSPHDGFKVDLPKSAEVVKVVEMPMESASSSGSNDTDSTSTSSSSGTSSSSHLLPALLSSTLALSSSLSFLGLAHALLAATFSEFELGSVTCAVSGVGFTKDGLVVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ90</accession>
    <name>U4LJ90_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized ATP-dependent helicase C582.10c acc. no. Q10332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935713">
        <property type="protein sequence ID" value="CCX12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ90"/>
    <dbReference type="STRING" id="1076935.U4LJ90"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSCNHPD"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="172"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="639"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="838"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="899" mass="100882" checksum="74E1740294531904" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJD3</accession>
    <name>U4LJD3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJD3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012249275" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13392" checksum="828C335EBFDA017D" modified="2013-12-11" version="1">MLIIVELDLVAMLHAVTYESACHPRPSLTQLGSASQPPSRNITIAHRCHYPAPPCPNHKHRHCYFIPSPDVPLFCSSRSVAAYSPLHGVGAGFLTDRCLRDHNLTQLYRRHYPVIHFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKK1</accession>
    <name>U4LKK1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKK1"/>
    <dbReference type="OrthoDB" id="10405736at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53742" checksum="D73F343394853E84" modified="2013-12-11" version="1">MFSNHGASIYQNTFMHTISSSNGHNTPVRVARPLSTSSHIMECPQADCIAFALNGVCHKNFCRYRHLPYSSFSRDCRYWVESGGTRCANQEKGNPCTFRHEGTHRQRSRSRLQEQQRQTYVAPSLLQAVHTSVTYPASAIGISSPVNVYINPGTQFGRTGNDQTDSRLPAMLRNYKTPLREQYRDQRRRNSDAKELTPNYHSPESRFRYNGSTSKFNTDSITITVSDPDDSSMEDAGPKSSRAVKSNPVIDSKAQNLREKLLLDKKMKEMKEKAREAVMNAPFKRASPSNAPSSISSTDSLGSHDFEVDGRSTPPSSPEKEDIPHQGRKRKRQHDPEDQLTVEMVREFLERLSRTRSLSLKRVNNKDNIGRDTKKVDFQREVLEDLCRPEGYVCPASQDQAMADKIHVWVLARIEARIGELEKELSKSEPSDEEDEVDYGDWNEEEEEKERAKLEEEARSYVFKGIVVGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM00</accession>
    <name>U4LM00_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Dimethylaniline monooxygenase [N-oxide-forming] 1 acc. no. P36365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935967">
        <property type="protein sequence ID" value="CCX14378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM00"/>
    <dbReference type="STRING" id="1076935.U4LM00"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSKARCY"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX14378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="593" mass="67248" checksum="011B656DBA9B01ED" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM30</accession>
    <name>U4LM30_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM30"/>
    <dbReference type="OrthoDB" id="10500883at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="9188" checksum="F629E9EA88FAF0E9" modified="2013-12-11" version="1">MTPAIMTAAPATLALPHDNFIPAFGTEDALALEVAVGVAAEAFSVPDVGVEVGAPVPVKYTAPSSLVNVAVARTLASVGHWSAEKDFLIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM42</accession>
    <name>U4LM42_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM42"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="52" mass="6124" checksum="6532874B9947B746" modified="2013-12-11" version="1">MIQYFLRKSIDLETHSTVSRVLSIYYTQIFTHRLPGIKLPHLPFDITLGICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM81</accession>
    <name>U4LM81_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM81"/>
    <dbReference type="STRING" id="1076935.U4LM81"/>
    <dbReference type="eggNOG" id="KOG2803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QCKYINA"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="230"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="398" mass="44834" checksum="459536B1D181B6B7" modified="2013-12-11" version="1">MAPMADELPEHPPKVAFPMDEQRIWIDGCFDFTHHGHAGAMLQAKRLGNYLVVGIHSDEEILTNKGPTVMTLKERELQVAACRWANLPVPTAPYVTEPHWMDLYGCKYVVHGDDVTTDASGEDCYRIVKQAGRFKIVKRTPGISTTDLVGRMLMMRTQHHLNLAKELEKPVKKTREEVEEMMEMMKNYASDAAGTVGKGPVVFIYSTETSATKKIVDGVLPAEGRKIIYVDGGFDLFTPGHIEFLRLVVEAATEEGKPAPYVVAGIHSDKVINDWKGQNYPIMNIFERSMCVLQCRYIDSLVLDAPFIPDATFLDSLEQTYGGKVEAVYHGPTQFMAAEENTYDEAKKRGIYKEIGPHGWADLNATAIMDRIMSEKERYLERQRKKGVKAEKEDNMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM86</accession>
    <name>U4LM86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to 3-oxoacyl-[acyl-carrier-protein] reductase FabG acc. no. Q9X248</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_14082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM86"/>
    <dbReference type="STRING" id="1076935.U4LM86"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="310" mass="32199" checksum="B17C3DC6F5FF2E92" modified="2013-12-11" version="1">MANERLQQITGHLGEIPQVAGSSTGKRLEGKVAIITGCNSTPSSANLIALLQSGIGRATAHQYASHGLKALFICDFDSSNLSSIAAELTTLYPGVDIHTRTFDASDEKAVEAVCEEAVEKYGRLDVFYANAGVVGSALTPVTEIAVDTFMWTLKVNVVSVFLAVKHASKAMMKTSASKPHSGGSIIATASTAGIRSGAGATDYSASKAAVISIMQTSAFQLAGTNIRCNAICPGLIETGMTAPLWNAARKKGSTNKIGQINPMRRGGVSDEIARVALFLGSDESSYVNAQFWAVDGGLSGSHPTAPGKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMF3</accession>
    <name>U4LMF3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936022">
        <property type="protein sequence ID" value="CCX33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMF3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4976" checksum="F6DC2A38491DBFD1" modified="2013-12-11" version="1">MPTCFLQPSSKGSCIIICSNSHGRTHSDPAWIMRVFVPAPKCNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMH8</accession>
    <name>U4LMH8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_08749</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMH8"/>
    <dbReference type="STRING" id="1076935.U4LMH8"/>
    <dbReference type="eggNOG" id="KOG2831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITAKKYV"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="80"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="266"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX30550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="344" mass="37188" checksum="DA05E8E38ED08867" modified="2013-12-11" version="1">MDLVNQFVPRNNPAVSDAVRVSDLINSLNDRLLFAVPKKGRLHQQCLDLLQGSDIQFHRHSRLDIALCLNLPMALVFLPAADIPRFVGEGRVDLGITGRDMIAEAQVEVEELLDLGFGKCKLQVQVPENGEYDSPEQLVGKNICTSFTGLAGEYFERLERDAGKKQEKSDTLQVGEIKGGARSGSTMGRLATKIKYVGGSVEASCALGVADGIVDLVESGETMKAAGLKAIATILETTAILIKSTHPTNPELIKTIESRIRGVITAKKYVLCTYNVPREKLAAATEITPGKRAPSVTTLDEEGWVAVSAMVEKKAIANAMDNLEKIGATDILVMNIANSRTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMQ1</accession>
    <name>U4LMQ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMQ1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="18610" checksum="9953423797DD1DC8" modified="2013-12-11" version="1">MDQVLWHSLSNNEKEMKDLDEKIVKAQNTQDLRMHLAEGRRKGLLVPDDQKTGAASANGNVLNAYPRAEHTRLAEDHDNSRKKRRRLANGEMVLNLVANNHQAVTINHNHQGEPGDRDFSPNDNCILDVTQKRIPSAKPYRSRSASARIQTRMAFHKSQTNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN32</accession>
    <name>U4LN32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Sterol regulatory element-binding protein ECM22 acc. no. Q05958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN32"/>
    <dbReference type="STRING" id="1076935.U4LN32"/>
    <dbReference type="eggNOG" id="ENOG502SJ8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYSSEWH"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="43495" checksum="F18FC465D9F96F71" modified="2013-12-11" version="1">MGPIRPHKKSRTGCKTCRGRRVKCDEVHPICSNCARRELTCVYDPPPRIEVQSLLSTPTPPPKPESPSYAFLNLFSIPPSPHPVFSHLDLTRLELFHQYSTETYRSFSNHEPWLPVWRDAVPKLCIEYPFVLYATLAISALHLSVKHSAKDPRRSQHYQVLATSYYNEASFALREALPRRQSLEPNALFVTSSFIAIYVFACPAVAERHGSPRALTWLPVLRGIPALVSGNWDNITDGLAPPLRHAPQHAPSESRSSLPPLPPLHQLTDGVEDEADKIAYTDAIKALEMAYSMHQRVSEQFWVAAAFVWPVKIPEGFIKLLIRHEPRALVLLAHYGAMFSKLQGFWWIGSRAREELEIIERIVGEDWTKVWLGWASKDWTGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNS4</accession>
    <name>U4LNS4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Probable ADP-ribosylation factor-binding protein C25H2.16c acc. no. P87157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_14277</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNS4"/>
    <dbReference type="STRING" id="1076935.U4LNS4"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PDNYEPN"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="189"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="501"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="622" mass="67219" checksum="829B3E2B78DC01BA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP62</accession>
    <name>U4LP62_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP62"/>
    <dbReference type="STRING" id="1076935.U4LP62"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="50175" checksum="F80F26271CD9BC12" modified="2013-12-11" version="1">MTPPVHALPSSGSQSRPTFSLPVPGTPSASLSVYKARLKAAFIGANPRVCTAFFLFGLINNVLYVIILSAALDLVGPDIPKAVVLLADVVPSVIMKLISPYFIHAVPYRIRILILVALSFVGMQLVAWQTELPQRLFGVVLASISSGLGELSFLGMTHFYGEFAIPFWGSGTGAAGLLGAFLYVCATSWIGMSVRASLMTFGFLPVIMIIAFFMVLPQAPLKGQRRGYEPLVEDDVGSDDENIPGSEEGSLMASSMHSSSAFPPARLGKEDWVQSLKIKLGRTRKLFFPFMLPLLLVYIAEYTINQGVAPTLLYTLEKMPFAHYRDAYPMYGTVYQIGVFISRSSTPFLRVRKLYPPAFLQCINLAVLTLHAMYDFIPSIWIIFAIIFWEGLLGGLVYVNTFAEITDTMEGEEREFSLGATTVSDSAGICVAGLISMGLEPFLCGWQVARGREYCKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP88</accession>
    <name>U4LP88_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Acyl-coenzyme A thioesterase 8 acc. no. Q8VHK0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP88"/>
    <dbReference type="STRING" id="1076935.U4LP88"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QVWFRTN"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="215"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="361" mass="39893" checksum="EAEE8DB26F4844E5" modified="2013-12-11" version="1">MTRPRSASATVKPPPPPDPTISPIENAISLSPLSELGPNVFTNTRPQWQPIGARGIYGGSVIAQCLLAAQLTVPPNFVVHSMHCYFVLAGNSNIPIIYHVDLVRSGRSFHTRTVQAKQRGNVIFTTTLSFTIPLSTKFEEGQGVGRVVKHQPTFPSGVKGPEECENELQVIDRLVKSGRIDEEQAELARARYGQDPFEFRSVGVSPDLPQSPDTPINSVPPAEKVMRQWVRSKSPIKDPLFYNPALAYISDSWFIGTVGRVNPEARRDKVGMMVSLDHTIHFHAGEKTRLDEWLLLETRSSWAGEERGLVRMNVWTQSGELLAQCLQEGMVRLKDGREGTDVQHAAAGTSTPKELKESAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPG4</accession>
    <name>U4LPG4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Heat shock 70 kDa protein 12A acc. no. O43301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPG4"/>
    <dbReference type="STRING" id="1076935.U4LPG4"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNQVSWF"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="685"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="979" mass="108034" checksum="3BD1D56BD3806572" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRN2</accession>
    <name>U4LRN2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkyl transferase</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07748</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an active dehydrodolichyl diphosphate synthase complex with NUS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRN2"/>
    <dbReference type="STRING" id="1076935.U4LRN2"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FDRRDLW"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000002">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX29951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="332" mass="37935" checksum="120A08731CEE7325" modified="2013-12-11" version="1">MPSELHTSRTRRWLLSSPPVEWASTQLKELFINSVRQGPVPQHVAFVMDGNRRFARKNHIETVEGHNMGFEALAKILEVCYKSGVKVVTVYAFSIENFKRPLHEVNALMEIAKIKLMQLCQHGDLLERYGASLRILGERDMVRPDVLEVIDEAVEMTKHNDRSILNVCFPYTSRHEIAGSVRDIVSLSTSAEPKPPGSPSLSDDSMSSGETATPGITDFEAITEETITDHLLTAGCPPLDLLIRTSGVSRLSDFMLWQCHQDTEIVFIDCLWPQFDIWKFLPILIDWGVKRRKMEKAGLVEVKREGNRKDAELNSHRQRELEERRRARLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRW2</accession>
    <name>U4LRW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRW2"/>
    <dbReference type="OrthoDB" id="2559326at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="11640" checksum="EEF6C5DACE6C812C" modified="2013-12-11" version="1">MPRITSNSYHLFRYGWAALIVAGGGAYIFARRDIDASRRQKALDLRRRRHEQRAAEFDYRADNSISTSFNPASEASQDPAATRHEPRPGEKSKFEANKGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSP6</accession>
    <name>U4LSP6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSP6"/>
    <dbReference type="eggNOG" id="ENOG502TB9N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEWDKGL"/>
    <dbReference type="OrthoDB" id="5429355at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="179" mass="19669" checksum="994C639A80B75DF4" modified="2013-12-11" version="1">MDAPQLSTRASLALASLTSQLSHLESQQTALLTSMSLTAGSLSSLPNFTEVAPTMQQIPTYTAKLARLRRIMAQQQQEVENLKRRALEAGKRRREHTVKLREREKEEAERDRSVLRAKHVEEGRDTPQIDDNFGPSEIPSGDAGRATPSSVSSGRSGTPVQGAVKIVKKKKKARKAEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSQ8</accession>
    <name>U4LSQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSQ8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="29" mass="2965" checksum="3D04129A7EAEA82E" modified="2013-12-11" version="1">MTSNSTERGGGAGQMNFLLHISTGRATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSY8</accession>
    <name>U4LSY8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_13355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSY8"/>
    <dbReference type="STRING" id="1076935.U4LSY8"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFADDEW"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="506" mass="55021" checksum="E0D40E4A0C24AD0D" modified="2013-12-11" version="1">MSTSHKAPAAYDSIIEHIGATPLVRLNRLPQSLGIKAKVYGKCEFFNAGGSVKDRIARRMIEEAEREGRIKPGDTLIEPTSGNTGIGLALVAAVKGYRCIITLPEKMSSEKVSVLRALGAEIVRTPTEAAFDAPESHIGVAKRLQKEIPNSHILDQYGNVNNPLAHELGTAEEIWEQSQGKIDAIVAGAGTGGTITGIARGLKKHNPNVTVIAADPVGSILAMPESLNTSHEGYKVEGIGYDFVPDVLDQGIVNTWIKTNDKSSFQYSRRLIAEEGLLVGGSCGSAFSAMVEALLKTNPELNQEDKTVVIVFPDSVRNYMTKFLDDSWMMNNNFHANEPTPCKAPKIRDLNLKPVVAVTKNNTAEEAMDIMREKSFDQLPVLSDSNSKRLVGLVTLGNLLSYISRGRATAETKVAEVMFDFTKLHDVVSDPSEIGQLKKQQRRKFDEVTLDTPLDALGRFFEHNSAAVVTEREADGGMKVLHVVTKVDLLGYLVKAKKAETNGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTE3</accession>
    <name>U4LTE3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTE3"/>
    <dbReference type="OrthoDB" id="10316326at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20073" checksum="CCDB04DE0798B6DB" modified="2013-12-11" version="1">MAQNPEQSTTPSSSPPPSKKRTYSDTIPQGEVALATASSSATERPGQSSSATPPARNEREGSTDTLLQPLPPFDWTAFLGNCTSEQASVSAEEKELLEEYHSWVWLYELWVTCRSKDQNVRLNREMATIVRWMQLEEQKIEKTRQQHAEVAQKISMVLGLTGLLGGVGRSGGVGGLGGAGAAGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUJ9</accession>
    <name>U4LUJ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to AB hydrolase superfamily protein C4A8.06c acc. no. O14158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Gabaldon T."/>
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    </evidence>
    <sequence length="56" mass="6619" checksum="862F5CA62CC9639C" modified="2013-12-11" version="1">MSCQSLAMFHLFRSNPHSYRAYYRKEWPEYAATSEVDVSPLGMHVVEYANEHRVLL</sequence>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5004651865" description="Magnesium transport protein CorA acc. no" evidence="6">
        <location>
            <begin position="22"/>
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        </location>
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            <begin position="407"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="460"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56802" checksum="B7A1BF7B0205E83A" modified="2013-12-11" version="1">MYPLSLFFVFSSLFGCLDSSAQYPLNPDTSFITPQYIKTSSISQATPPSHPLSGDMSNFNLQHKKRIPLSLGADQSGTPGIYASLYQQALDRARFLPQAAGYIEGWCYTNPDSSDPDYAVIDENHLPVGRIEGWIDGENGIPEPEDNMKRVGGFRLLITYSTNPTKKSQGFGRDIPYTRSTFENLVEKFKLPKQSLELVSNSSSGVFAHTLNLTTGLIHYWDWYSGLFNMFLSLLRSDPGRCMNPYFFPITFLKAHNWWSESFRSHLNDLMTSFADLDDYEAGNISDTDGLGGGPGGKSERDIRNTMNEISRFIHNLPTENSHAVFQGNTCEMLLKELEGKKGQEELYEVLGLLRFQIAGHTEAIGNLRTRIEARNSMLYNRMSQTESRLNYQIAKAARMDSYDMRAIALLTTFFLPGTFIATFFGAQLVKFDDINSAMKIYWALTIPLTFLVVSAWQFWSWMHKRHDSAKESGGRDAQPVEMVQREKGVQRTWSSHNTSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXL7</accession>
    <name>U4LXL7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized serine-rich protein C1E8.05 acc. no. O42970</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936554">
        <property type="protein sequence ID" value="CCX34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXL7"/>
    <dbReference type="STRING" id="1076935.U4LXL7"/>
    <dbReference type="eggNOG" id="ENOG502S73X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWDVPSK"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652735" evidence="3">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="218" mass="21434" checksum="16AF7F3F46CB9FA1" modified="2013-12-11" version="1">MRFFTTSAFAMAIATVAALPQTAISGGANPITAPVGDVALEAGKPFTIKWAHDFGKQVTLNLRRGSDSSNLDDILIIVPQTANDGEYTWTPPTGLKGGKDYAIEIIADGSANYSPRFQIDSKGPGIGAETAVPTSTKAASTSAAASSKAASASHSADASATPTPSASESAQASGSDASAVPTATGAPVAAAAPASGAGTVGASLTMVMGAVAGALFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXN9</accession>
    <name>U4LXN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="8" mass="1014" checksum="E8A454140EA761E6" modified="2013-12-11" version="1">MHPCRRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYI3</accession>
    <name>U4LYI3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYI3"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14651" checksum="33FE478D0FA243C0" modified="2013-12-11" version="1">MATRNGDATILAYLQFIIDHQSQLPNYLLFIEHHSGTNLKSRSSLWELIQAGTSLWDIIFLVPNDVSARLCRFTDWSEPSESTYAKAMYDFLASELGLDPTAPPYIDTLNEATFLVCRELITRHPGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTW8</accession>
    <name>U4KTW8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935207">
        <property type="protein sequence ID" value="CCX04523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTW8"/>
    <dbReference type="STRING" id="1076935.U4KTW8"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="218" mass="24508" checksum="BF29852B396DDAF8" modified="2013-12-11" version="1">MMSSLFSYFGGGGAKKNNSKEAIVKLRQQLEMLRKREIHTEKQMLEQDAIARKNITTNKTVARAALKRKQVLEKNLEVTQQHINTLEQQMNAVETANLNLETIKVMKEASDAMKGMNKRVGINDVDETMEEIRENMQLNKEISEAISSVQITDPEEEEDLETALKELEQQALDDKMISAPAVPVGTHGSAISAKPVAAKPQEEDEEEELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU39</accession>
    <name>U4KU39_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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    </evidence>
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        </source>
    </evidence>
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                <person name="Kumar A."/>
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        </source>
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    </dbReference>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX05058.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="129" mass="13812" checksum="3C41599661AF36E0" modified="2013-12-11" version="1">MDSPYLRFLDRPAIRSDYNHAEGRQLSNSKSSNSAPQLPTHKCSSAPTGQKSCKPNVDAVVRRIGALAGSALIHPCQRAKAIASSKADKVDSPGFPCPPDVSSSYATKKNIQVALGRRHCHGCQDIPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUN0</accession>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <source>
            <dbReference type="EMBL" id="CCX04787.1"/>
        </source>
    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUP1</accession>
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        <recommendedName>
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        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
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        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
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    </protein>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:enzyme regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
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        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX05083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="274" mass="30275" checksum="18CA3FC69AE26529" modified="2013-12-11" version="1">MASIQCILNTGNIMTAASEVLRSPPKSSTELITSLRSHIRSSPPSPPPSPSLSSTTKSPLYIPLPPTPEPLAEERSEYDVTVKLFHLSSAPTASHETHTRDAVKRVLENLGIETIDLLILSLPGINFDADDFANEDSTEDVEAWLATYQTLEELHQDGVISRLGISEFGTTRLEKLLPRTTIKPSVNQINVRDCCVVPKPLILFAKQEGIELLTHNDCTDILPQETLQNVLVDEFALLGEERKVMPQWVAKYTAVIRSRGVVENKGYIAMAEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUT0</accession>
    <name>U4KUT0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUT0"/>
    <dbReference type="eggNOG" id="KOG3021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DMYYLID"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="41650" checksum="821764415E3616F1" modified="2013-12-11" version="1">MHLMATPTAGGDLDQSVDIEECVFELLPRGTTLLSASRHHTDHLTRSAKLVTRHADNSVHVYLLLGSSGSLGRQLLLGHHASLGTIHSYLPRLCPKPIGCGRFTTFKGYFTLSTFHRRLGPPSDAGTFLARLVKLHRIEAPDGKFGFRVPTFSGEVLNPAMSVDTWEECFTALLTHALQTEEEVNGVDKELSSLTEELLQMVIPRLLRGLKVKPVLVHGDLTVENSGDTDSVSQIMFWRPAVLWGHGEYEMGAWAWGSRWIRGYLKVGDIAEPREEWEERWRLYGLRHTIGRSVRYPGSTKYRRMIKEEVRWLVERFRPTVGEELWAEEERRERETAVERELSRKASSGSSGRMKARGGRLVKSPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUW0</accession>
    <name>U4KUW0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_04800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUW0"/>
    <dbReference type="STRING" id="1076935.U4KUW0"/>
    <dbReference type="eggNOG" id="ENOG502RZWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYLRYHH"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="42"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX05213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="266" mass="28385" checksum="3CF32724A5AF721F" modified="2013-12-11" version="1">MSTPLELPASVSPFLSTYLPPASPSSSPDPLEPEETEPASRPFVTLTYATSLDSHLSIAPGVQTALSGPESKALTHHLRTFHDAILIGASTAVADDPGLNSRLPGTTLSQQPRPIILDPTFRWQLTRESRVLRTTRDGQGLAPWVFVAKEPEAGDVRVGVLEEVGGQLVVLEQEDGKEWGWEKILAKLAELGIKSVMVEGGARVANGLLKRGDLVDSVVVTVAPVYLGKGGVNVSPEGVVRFRDVAWCTLGRDVVMAGRVELVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVB1</accession>
    <name>U4KVB1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Aurora kinase A acc. no. P97477</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="173"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="520" mass="58149" checksum="2EE7B8EA18C9E53B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWF5</accession>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
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            <end position="634"/>
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    </feature>
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            <end position="688"/>
        </location>
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            <end position="709"/>
        </location>
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            <end position="736"/>
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        <location>
            <begin position="758"/>
            <end position="776"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CCX05446.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8871" checksum="46930A6D14CCA9A3" modified="2013-12-11" version="1">MATIPKASYGVRYMVYRRYRDYEVSRCLDLGRLGFFTTLDEANRAAEMISVAEFGEGYEKEEFNNGLVACKRLGQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXY7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05987</name>
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    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4KXY7"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
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    </dbReference>
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        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ChtBD2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650942" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8449" checksum="EE46A31038B1F0F9" modified="2013-12-11" version="1">MQYTIIAVLALAAAAVAGPAESCPTQDEKTPTTFVPDNQDCGVFYICDRNGQAVKYDCPTGLGYNPNTKICEQNGCKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY61</accession>
    <name>U4KY61_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Chitin synthase export chaperone acc. no. P0CM73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4KY61"/>
    <dbReference type="STRING" id="1076935.U4KY61"/>
    <dbReference type="eggNOG" id="ENOG502QTJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWAFWSS"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="301" mass="33347" checksum="1E49EC5BAD8764EC" modified="2013-12-11" version="1">MSQFGNFHDFCRDSTLPVCNIFAQNGLQFDGGIEKSCELKGFAAGDRNIRNLGTVLLCAVALIVTAILYWRSERKKAAVGRREMQVLLCAYALVSMTEMFSVGGFLQDRKVLVWFSAIHIGAIAATFWTLLINAIVGYQLMDDGTVLSVGLTIFSAVCVFLGVAYIGVDSGINYTGEFVVQNRAELKNYALYVCYLLFPLLACVAFFILEAMLCLKVLKETRPLVLLTISAFLFIISQIFQFVASVHICNATAGKIDGALFETFTVLLAVVTLWFFWSSITEDEWPDDPMNSTIQSEQAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYA2</accession>
    <name>U4KYA2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYA2"/>
    <dbReference type="STRING" id="1076935.U4KYA2"/>
    <dbReference type="eggNOG" id="KOG3908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="279"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="303"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="453" mass="49313" checksum="E35D5194D1CA69DD" modified="2013-12-11" version="1">MLKTMTTLVTDAASAIPKMPSALTFEIRARCSITKARASVLRLPHGPIETPIFMPVATQASLKGLTPEQLEAAGCRLCLNNTYHLGLKPGQAVLNKVGGAHKLQSWNHNILTDSGGFQMVSLLELATVTEKGVEFLSPHDGTPMLLTPEHSIDLQHSIGSDIIMQLDDVIVTTSPDDARMREAMLRSVRWLDRCIAEHMKPDALNPSATYAERQNLFCIIQGGLDLDMRRECAEAMVARDTPGIAIGGLSGGEEKDKYCAVVKACTDVLPEGKPRYVMGVGYPEDLIVSIALGADMFDCVWGTRTARFGNAITSGGVLNLRNAKYANDFGPVDPDCNCIICSPQDSPARPPLNNSLSTPSYADTNYSAKGLGISRAYIHHLAAKETAGAHLLTMHNVAYLLNLMNKAKQAVIEDRYPQFLKDTFGKWYNGDKEQFPKWAVDALRGVGVDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYH9</accession>
    <name>U4KYH9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYH9"/>
    <dbReference type="STRING" id="1076935.U4KYH9"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="213" mass="24022" checksum="ADBE98D9E6C19909" modified="2013-12-11" version="1">MATIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLGFFTNFGEIKFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLTGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPTLEFVASPALAPPEVTVDKELLAQYEADMNAAAQQPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYV1</accession>
    <name>U4KYV1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">PCON_06442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYV1"/>
    <dbReference type="STRING" id="1076935.U4KYV1"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="358"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="623" mass="70207" checksum="DDAB6402BC544386" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYV3</accession>
    <name>U4KYV3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYV3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7061" checksum="64892B6546F1E2C3" modified="2013-12-11" version="1">MIVSCRPGSPSYVTGQAALMQGPAYLEYLEYLEEHSAGIAGGLNGETGWKLQAGKVFCFMRGDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ57</accession>
    <name>U4KZ57_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ57"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4598" checksum="839E4186D89455E9" modified="2013-12-11" version="1">MFLERLMIILRRILVGTVLSSILRLRFLFQGGSPCLLSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L012</accession>
    <name>U4L012_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L012"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18256" checksum="BDA40B4B841A05CA" modified="2013-12-11" version="1">MALEGISVASSITALLQTGNVIADFISRMRGASDTIQKTLAELREWELLFKQIPSLVESLDGFEGMGDRRQLVCADSPVVTLSECFASYTRLATIIRRVGEESDIKSNDKSALRLENLKISAIIALKDREIAQIIAYLQHRKSSLTFILLVFTAYVEILVFCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L039</accession>
    <name>U4L039_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Gabaldon T."/>
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    <accession>U4L157</accession>
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                <person name="Gabaldon T."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
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        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15231:SF1">
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            <end position="165"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX09687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="193" mass="21799" checksum="79B45C7842ABA724" modified="2013-12-11" version="1">MFTHPPTLQIRTPSPTTTEFIVTTRPPPSLSRTIVSVVVGSLRLVAFLTITTLLLSQHRLIPPWAALLQRDERLDPKWLYPISATVLWIIAQRSYTEESLLVIRSLGVQTSTTAGTLIGMGRKTRFIQTEKVRDVVINEGFYGMEVRFYLAVLVEGEAALSVVFPTLLPGRRICEQVWRGTRRCLYQGEKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX08355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8216" checksum="8E400E95D1444D6A" modified="2013-12-11" version="1">MGNGYSSGAARIGISINGLSHYFSNIQIALVTETLNRCIAIGFVLQSLHPSRCLPLPTEHIINTYSCALFCVVLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2S8</accession>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX04370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10940" checksum="47C70D232A1D2D91" modified="2013-12-11" version="1">MVKATYQPKWLSEFMIMRIQQHYVRDSVLPIPLRPERFGSCVGPPVRRHVEPSRAATYCSWGALRQAIPDSSGFRIQASPDLASYRQASRGRFCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3N3</accession>
    <name>U4L3N3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Superoxide-generating NADPH oxidase heavy chain subunit A acc. no. Q9XYS3</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0043020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="241"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="546" mass="62844" checksum="11AAD1D5BC18BF41" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3S3</accession>
    <name>U4L3S3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3S3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4726" checksum="F55950BFFEEDF3D2" modified="2013-12-11" version="1">MVSRAGFVCFGVDVTMLRWMFILRCDYDGSMVISTAQEFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4A3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11328</name>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <begin position="132"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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            <begin position="54"/>
            <end position="77"/>
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            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCX07223.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="189" mass="21139" checksum="642FF9210C80552A" modified="2013-12-11" version="1">MSKSCLRRKKAISPSTCNLRGKFRRQLKDKAKQQHLEYYLQQQQGPAQEIVEVLSSSDLSSDSSSGGSTSPPTDYSSNQQDHDNFHAPDTTNTEICSSDETDSWDLTDDISDDGEDGLHTPDDSGDEAGRGVLMKSREPVIDDDGNEVYELAWTVMEPVIELVMDEEKVKGAYTVMKEGVMRLWRTVRS</sequence>
</entry>
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    <accession>U4L5J0</accession>
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                <person name="Kumar A."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="2">CBS 100304</strain>
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            <dbReference type="EMBL" id="CCX05365.1"/>
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    </evidence>
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        <source>
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</entry>
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            <fullName evidence="1">DUF7881 domain-containing protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L5P6"/>
    <dbReference type="eggNOG" id="ENOG502SKV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="1">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14329" checksum="FFCBBB804323769A" modified="2013-12-11" version="1">MPVDRSLGRNVRFYDSSKPSITLGGFIQNGSVTETNFLDMMEILLTEAPPRVQERTSGHVVATTNNLLQPGEYDVYCDSPIEVSNEPWVHRLISHNLSGREDAFRDGIRSRDGKCVISGLVNSRAFCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5W6</accession>
    <name>U4L5W6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5W6"/>
    <dbReference type="OrthoDB" id="5342985at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="551" mass="57835" checksum="1B3BE59D86E3BE41" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6J3</accession>
    <name>U4L6J3_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to mRNA degradation protein pet127, mitochondrial acc. no. O74832</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_12632</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935762">
        <property type="protein sequence ID" value="CCX13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6J3"/>
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    <dbReference type="eggNOG" id="ENOG502QPU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PEAYHYS"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="678" mass="76959" checksum="31E2992D32E34E41" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6M5</accession>
    <name>U4L6M5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935679">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6M5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15148" checksum="A181E5D1DC82F3A3" modified="2013-12-11" version="1">MSFNALPNELLHEIFSYIDDPFDCKDFLRISHRTYNACNASFNMRFRLYIDADVKFKGYFVEDAAFVGWTRFVRKYLPPLHPRYVEDVIERNTRKRRMHVVELFGGDISEGRDGTSKGDSGIGSILGQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6R7</accession>
    <name>U4L6R7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6R7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11822" checksum="A120EFE6A09A7E00" modified="2013-12-11" version="1">MRRLEMYVFELELNRWKGRSEGIVVPKFLRWPGLCGAVQSYLIPHHTILSLGRSNSILPALVLSSGHFYSLKGGLGKPQIGLCFPIRYQSSRGALSKSFFNELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6U4</accession>
    <name>U4L6U4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Major allergen Asp f 2 acc. no. P79017</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6U4"/>
    <dbReference type="STRING" id="1076935.U4L6U4"/>
    <dbReference type="eggNOG" id="ENOG502RTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative peptidase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="351" mass="37885" checksum="2AD71AF892D040B0" modified="2013-12-11" version="1">MSLVLVSVKSALNGTLGDHSTSIRFSGHSLVMIFHRKTCNIAIQARKNRPGSQEHCEPWNFFTKSRTLLADKTAYNHEQTHLERPASDQLRTRQSPRFITLTGACSILPTMHASLITALFAAVAAAAPAVKNDAPVALPAIENILGPLNITISGSCNATEARQITAGLNDAAELASVARSYILENGNSDPTFVKYFGVNASSAAVIGVFDRILYGNKNGVLIRCDDVDGKCAKSPTWAGHHRGDAAPAETVICGPSYLERLYLPQMCSRGYEISKSKLNLFWGSDLMHRLFHVPAISENNVEHVKGADGYEGTLKLAEANDVRTVENSDGLQYFALDVYANRVAAPGVGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7M3</accession>
    <name>U4L7M3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 40S ribosomal protein S16 acc. no. Q759L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7M3"/>
    <dbReference type="STRING" id="1076935.U4L7M3"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX13673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="146" mass="16187" checksum="2468B93E6698FA04" modified="2013-12-11" version="1">MAGDAPVQSVQCFGKKKTATAVAHCKAGKGLLKVNGQPIHLVKPEILRFKAYEPLLIVGLEHFAGVDIRVRVTGGGHTSQIYAIRQAIAKSIVAYFQKFVDEHSKNHIKQLLVSYDRTLLVADNRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8N8</accession>
    <name>U4L8N8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936128">
        <property type="protein sequence ID" value="CCX15048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8N8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="3456" checksum="33A44847BB969DC4" modified="2013-12-11" version="1">MDGLLIHLRNFRKCYLRRKHFPMHYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8U0</accession>
    <name>U4L8U0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Carboxylic acid transporter protein homolog acc. no. P36035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8U0"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSEKHIC"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="57002" checksum="B98E552E40D21540" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L912</accession>
    <name>U4L912_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D acc. no. Q769K2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-B-lactamas"/>
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    </dbReference>
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            <begin position="167"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="434" mass="48406" checksum="008BFDFE231B4E70" modified="2013-12-11" version="1">MLALSAAHASRFSTSTAVATRPFRELVSYVIPHAKKAEQQARTFTTTTPAMSGTQGIIAEAFSCSVNRPQTAAKHPQAFYEKKPHHLKNSRGFQNPWDSWTDGGITQIFKGVLTHRYKNGFGGPVTEPAPNVIKPTFPSTRSTDTTELRATWLGHACFYVEFPGGLRVLFDPVFSDRCSPSQFIGPKRYTKKPCDIEDIPEIDVVCISHNHYDHTDHATLMKILKKFPNCQYFVPLGNKEWFTSCGIKTCTEMDWWEDREVELTVKEGKLNATIGLLPCQHTSGRGLTDRSLTLWGSWYVKSGGKNVYFAGDTGYRAVPQESDGKDDYAAEYESLPVCPAFKEIGEHRGEFDLGLIPIGAYVPRCPMHADPKDAVNIFLDTKCKKAIGMHWGTWVLTDEPVMEPPTRLKEALAAKGLEETGVFDAIDIGESRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9B3</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX06774.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="596"/>
        </location>
    </feature>
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            <end position="633"/>
        </location>
    </feature>
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            <end position="852"/>
        </location>
    </feature>
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            <end position="888"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1756"/>
            <end position="1775"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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            <end position="2052"/>
        </location>
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            <begin position="43"/>
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        </location>
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            <begin position="559"/>
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            <begin position="2380"/>
            <end position="2389"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX06774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2423" mass="270617" checksum="A756E436B6E48DF0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9U0</accession>
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        <submittedName>
            <fullName evidence="2">Similar to TPR repeat-containing protein P27G11.02 acc. no. Q9P7N6</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX15460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="405" mass="45037" checksum="802AB5F1AFF58DAF" modified="2013-12-11" version="1">MFTRMISGASARRLPTIASRLPTANSALKQPIRRYAGSYQDTFQTPESGFKALYQRNRVSFLLFFAVCTTTLVAGGYGMYLYNELVEKPLSVYPKPVQKAIKSALFYASRGDMGSMAAAFKEAISEAEKSGMHPLSNEVAGLKIECAQLLLKLKNGEYADKAVIVLERVLDEDAAGAEYYMKQERWADRNTVLKRAILLGYKIGEMYQTLGKDKEAEEAMSWSTTKLLEEDKRRETTDPSKWGGEWFDDHAKSACFEKLAQQYLMSGKFNLATPLYLQAASLVTPNTCHQVTLLNNLAACLSKQSPPANSDGKKVKTHLQEDAKKWAEKALELANKIVPPVRTAECDEACVTATHNLGEIARMMGQHELARRKFEEAGSLARGLNMQEGVEMANEGLALLMDKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="494" mass="54532" checksum="D35842C65E21D8B3" modified="2013-12-11" version="1">MSPNTRQKDHSKRRWTSFSLPSRLQRGLSFFSRRRSLGGGCDTTPVLPHCSNTITSTSRTSITSSILTTSTMDYEEHSETSHSEHHHTWHVRRGSASSIGSLYPSSPGRCLPPPRAPTPGPSCGCSSRRCSGGCFGGGGGGSTLVGPGGPGLYVWSAIKDNWCPPTSYDLAGQVPLGGNRIKVYSWHLSGTFTHAYSRTACAVSMIEKDLEGSGVGYCAILLQDVTDTGLQAILEHPWIRNCFQTTNRDRLHDNGETPFTITLISKCLKICSITRSPYDECNKQDDLLIVDIAVGGGPCFRLGNSFQHAGSLEDHDFKREMVDKRMNEDHVIGGVVGGNMSAFNSGNVQSLSPPYRDWRPCLKDIWIEFERRNDIHNLSPREKRELAETGGDLGHTWGYQPIEPEVKTCRLIGRYSKILYCGKETMCEPDDGMFLRRIGVGAKCEYRSGGYHRNSRERNKKGWVSEHYGLAVTFYLGRGNRDGDCGCGCGRPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBR6</accession>
    <name>U4LBR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBR6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6735" checksum="B0576682ADE39A13" modified="2013-12-11" version="1">MTHLQSVNSLRLKISCSMHRDLVHNAETCIPPSYHRNTNSEDIIASFHRHFNTYLHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC30</accession>
    <name>U4LC30_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative ankyrin repeat protein RF_0381 acc. no. Q4UMH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC30"/>
    <dbReference type="STRING" id="1076935.U4LC30"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="465"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="741" mass="81010" checksum="1619B9363AE4FB62" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCB1</accession>
    <name>U4LCB1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCB1"/>
    <dbReference type="STRING" id="1076935.U4LCB1"/>
    <dbReference type="eggNOG" id="KOG2444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAIHPTE"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="431" mass="45948" checksum="C523DAC0B0E9F908" modified="2013-12-11" version="1">MAAQYEARSVNLTADLFTLAVHPTRPLFAAGLSSGHVYSYTWPTSSSSSADEDPNDSDDDETPAAAPTETDYTIAWKTHRHKNGGCRSAVYSHDGLSLYTAGKDGILKAASSETGRVVSKSILPKDDAASILLPLSAQHLLLGTDEGNIHLFDLRTPTTLPAKANASWLNVHDDHISSLLALPATAASTTGFSRTYISTGDTTLSSFDVRKPGKALARSEPQEDEILCSSFTAHAPSRNTGGSEKVMTGTSSGVVTTWNKGFWEDHQERIPLSRKTGDSIDSIITLTEDFEISGAGYGTFFAAGSGDGKVRIVKMGGNKVGDLLEGLEEGVSALAVDCDGRIVSGGGLVVKIWSEKEAQEVEEEEEEEEKEGKKRKGGDSDDDSDDDSDVEGESSDDEKEKKKRKKRKRTGGKGKAKSAGVKNVHSFAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCF9</accession>
    <name>U4LCF9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCF9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="180" mass="20688" checksum="FFDB0712C80A5D28" modified="2013-12-11" version="1">MLHPQDQDSPSISINKLTSKLHHLALGPARQQSSSSSSSTKPELTHITHTLQKLSLEQKQEQEILKKLAIEKEQEMLDQLMIALEQEKEKEMAKKLAMEKEEKDRLKKLTTEKDQEMLNSLVMAMKINSDAPDINAVTNSLRELMMEKEDSEDEDGYSEAATVGSERDMDWGDEEFRWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCG4</accession>
    <name>U4LCG4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_03169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCG4"/>
    <dbReference type="STRING" id="1076935.U4LCG4"/>
    <dbReference type="eggNOG" id="KOG2851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="58857" checksum="E045689DA0C13218" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE66</accession>
    <name>U4LE66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935468">
        <property type="protein sequence ID" value="CCX09518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE66"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="26" mass="2819" checksum="679EEF8D9A230EE7" modified="2013-12-11" version="1">MHGKGHAEPAGVYISIRSPPRIQGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEX8</accession>
    <name>U4LEX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEX8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3098" checksum="99C3DD4E4B99EAFC" modified="2013-12-11" version="1">MDSGIDSCESPDIELPEAITVAPIHQTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF71</accession>
    <name>U4LF71_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ankyrin repeat-containing protein, putative [Penicillium marneffei ATCC 18224] acc. no. XP_002144344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF71"/>
    <dbReference type="STRING" id="1076935.U4LF71"/>
    <dbReference type="eggNOG" id="ENOG502T205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWGHHLR"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="201" mass="23443" checksum="DAC4D65040668061" modified="2013-12-11" version="1">MPQEFKEQIINEIVSTSNGMFLLPALQIEAVLEKPTVRKRKEALKQMPRGLSDAFKVTLDRIRCQNPDMAQQAMDILQWTFLAQRGLKLEELRHALAVEPEDTDLDWENFIDAEGLLDCCLGLVIIDDSTSTVRLVHKSLQDYLKTEYEQNHIFEHGHYKISPTIDYMLDRALNMRMYRRFVLVMLFSNTLRIVGVFMHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFL1</accession>
    <name>U4LFL1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Uncharacterized protein C1604.06c acc. no. O94372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_09490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFL1"/>
    <dbReference type="STRING" id="1076935.U4LFL1"/>
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</entry>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9958" checksum="A88E6EF7A48DA8E1" modified="2013-12-11" version="1">MSDAELTKELQSLRLLRATLESVHQMVQGIGEDTTNTTQANYEVIGELAGRWEDVIKTLRRKTEEEREKKGDAMVEVREGKGRGVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH49</accession>
    <name>U4LH49_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ankyrin [Exophiala dermatitidis NIH/UT8656] acc. no. EHY59712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH49"/>
    <dbReference type="eggNOG" id="ENOG502T2F6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AIVDSCK"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="141" mass="15256" checksum="45DFC295932DCB36" modified="2013-12-11" version="1">MDPLSLCASVAGLISLALDVTTILNGYIGSVKSAPQEASDLNIEVAALSKVLPKLNDALRTDDISESTSDNQSILCAIVDSCKGHLTSVLEHIAKLRSISKVSEVMGRMTRPLKRDECLQSVHTVHRYVQTLQVLLVNSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHR7</accession>
    <name>U4LHR7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935634">
        <property type="protein sequence ID" value="CCX11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHR7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6612" checksum="E2FB852178C66979" modified="2013-12-11" version="1">MTMETMLWCVVSWRDMLKKLHVLWAVIPRADNYNHFHSKQIECSTASAFTENHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHZ6</accession>
    <name>U4LHZ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHZ6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="31" mass="3752" checksum="4E4704E13503B22A" modified="2013-12-11" version="1">MFGKDDILLLNSISKHCTNPRAIFYYIRRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LID2</accession>
    <name>U4LID2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LID2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="32220" checksum="B54E29225A9A7A1C" modified="2013-12-11" version="1">MGFKRKTRTSAGTTAVAPAAVAISPVPAPVPVPTPAPSDPEPQPQVTTEQPQTVQPQPPLVPLAPLVIDARQFQASPETPNPDPDVEEPPLKIRRGGRQPGAQSFKDEDKMRAFTAMKETKPATGADWDRCAEAYNAVATIARRKARDGNFLRNYWASCIKAGLPTPAKAHIEKRMPWEIKEAQGVKWDIETEIHRRHETVIVVTAAGHSYWTASTSTNSGVSGTGPSGVARSADGDPRSIRPAAAGASTSSCSTHKTSYAIHTSRDIHTTNSSGSFLPCGAGTGSTRSTSTSNNRICCAIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJM9</accession>
    <name>U4LJM9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Meiotic chromosome segregation protein P8B7.28c acc. no. O94276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJM9"/>
    <dbReference type="STRING" id="1076935.U4LJM9"/>
    <dbReference type="eggNOG" id="ENOG502SB6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3514033at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.210">
        <property type="entry name" value="Stc1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043069">
        <property type="entry name" value="Stc1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="40535" checksum="04E4F182B0BE2BD7" modified="2013-12-11" version="1">MPPKSNNPNFHTPAIGRNLVNQRSKVGVTGAINPAGNMPSNVTCYICKKSKPLDQYAKRQVQRFQDTIHNPYAPTGRTKKDPKVTCRDCTPQQTTELRCCVCEKVKGLSHFAKNQRRSRTEARCIVCLTGVLEIEPDDPNFVDGANSGDDNDDDQSHDDESEDDDEGDFDDASDAEDEKPKPPRVSVPGYVRSGAENRVPPKTDNWGRPKKQNRTLPKQENFDSFDDEEDITPAPRRTEDAWEGVSAAGRGRGRGAPARQPIVPVSYANVSNSRALNNSMYGGSSTPLAGSSVAPTTTTTTGRGSGRGGWAKPVKQTSAKYSSTEIRESSVWDKYARDLTNERDVGKQTNLSKKKKKKQTIDDGEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK71</accession>
    <name>U4LK71_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to 3-phytase acc. no. O66037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK71"/>
    <dbReference type="STRING" id="1076935.U4LK71"/>
    <dbReference type="eggNOG" id="KOG1225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACRGDNT"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="B-propeller_Phytase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50956">
        <property type="entry name" value="Thermostable phytase (3-phytase)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651669" evidence="4">
        <location>
            <begin position="19"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="374"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="725" mass="78403" checksum="73100ADA49B21DA5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKL2</accession>
    <name>U4LKL2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_12387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKL2"/>
    <dbReference type="STRING" id="1076935.U4LKL2"/>
    <dbReference type="eggNOG" id="KOG3976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YTEWADG"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="25994" checksum="42347BD9752D2C35" modified="2013-12-11" version="1">MSMRLTKTLAGAARLRPSAAALPRVGAAVSARYNSSVPATEPKAKAQSILDSLPGNSLISKTAILSSVAGLSVAAISNELYVLNEETVVAFCLLSVFTAIGKYGGPAYTEWANAQVTKIRDILNSARSDHMKAVEDRIESVSQMGNVVDVTKALFEVSKETAQLEAQAYELEQRTQFAAEAKSVLDSWVRYEAQVKQRQQKELAESLIAKVKKELENPKVLQQILQQSVADIERIVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKW0</accession>
    <name>U4LKW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935409">
        <property type="protein sequence ID" value="CCX30000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKW0"/>
    <dbReference type="OrthoDB" id="5274606at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="248" mass="27983" checksum="2ECED8DB417A882F" modified="2013-12-11" version="1">MDGEKIAPDTTSFYSISPPASSTAIEIGSEVNVGCFTSLRAAFFSWLWPLPVEEPRCEAFPYATQSTGSTAPLNPPSLFPEWTADELDTLIRRWLNTHPGPLSHPQNSEIASLITLVDTKNANRHDIEILHATLLHRLRMDHNTEQLAREIGLISYPAVFEEGGMIEDFEPPPGRPLTIAARRLLLECQGEWKEALMPLPKTGVRTRYRRPKYWLVSVAAANGWTHQELDEAMQQWFRERGDDGLFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLW8</accession>
    <name>U4LLW8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLW8"/>
    <dbReference type="OrthoDB" id="10358224at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="268" mass="30876" checksum="6D420CE3F5C2AA17" modified="2013-12-11" version="1">MTLAILRLTTTITATTELTHSAHYIPRYNLQPRILNPTPFNILQHSIRTYTHYIQYPPKMNSEKKNLNKNAVGCVLRITQQRAFDLIHSTASVDNINLLTRSSEICGKVESQYSFSAALGDQFEPSIDSQRIHEETTEFARSVLADMVMAIPVTSNYSTETVSSWSSMNDEEVESALSKYRYSPYFEQGVKFDSAIDWIRVKIFRREPISCDTRHREKILRDAIKAKYSPRGKCSAIKLNLRRWSLSPGERYELCEKYKRCGRSCPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLZ3</accession>
    <name>U4LLZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLZ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6644" checksum="7EE04029CCA13DCB" modified="2013-12-11" version="1">MNRAQTSRRMRMSRELVKKNIFHQLDKDVGILSVKMDTVQGSVKRLETDVKEVAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM79</accession>
    <name>U4LM79_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM79"/>
    <dbReference type="eggNOG" id="ENOG502QUI6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38286" checksum="6D0F2FBC9663D49F" modified="2013-12-11" version="1">MSEGSNQSQTKTPPMSPESKPKGQRQKDVDDSGRFGRKQSDKKIEATQIRTVLETFMSKEKTGLNRFYKDENLPEELVMRATTMASELIDLGCTRELAQSLAILNLYDLAILLDDSLSMVTEEEGKRLSALETTLEIVAQVYTLTREDGIGTIDFLNEPDGFADVVDTEIAEIIKDHSYSGWTRIGTELEAKILNELVTDDMKKPLLVLVITDGDIEGERDGVIASVIGKCIKDQQTKFPNHAAHAVAFQFAKVGNDIGAENLLEAIDNHKVIGDYVDRLPVGIEAISDLALKWEVLAKMLLGGIVRSFDKADTPAAQQTAEIEAPDKAARKRVSKAAQRAKQPPSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LME3</accession>
    <name>U4LME3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936136">
        <property type="protein sequence ID" value="CCX15146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LME3"/>
    <dbReference type="STRING" id="1076935.U4LME3"/>
    <dbReference type="eggNOG" id="ENOG502QW48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YAKDVEC"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="139"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="538" mass="61840" checksum="5AC00CC8C745B196" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LME4</accession>
    <name>U4LME4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LME4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="17301" checksum="58ABEE1AE52BC8B5" modified="2013-12-11" version="1">MQVSGALSTKSMGRMATYICSLLSDFPLETCICTFLSFGILQQANTSVSRVPGCWVRCSTSTIIEKSLSTMSASDVENTIEVDSFAPTPEDTDDEYQSSSYGSYQSSVNSVNFSIDEHVYENGRRYHSYFGTDKNPLPTDEVTTHHFKFRKHTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMZ5</accession>
    <name>U4LMZ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NADH-ubiquinone oxidoreductase 21.3 kDa subunit acc. no. P25710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMZ5"/>
    <dbReference type="STRING" id="1076935.U4LMZ5"/>
    <dbReference type="eggNOG" id="ENOG502S81D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMMNLRE"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="20742" checksum="545A7C043CDEC301" modified="2013-12-11" version="1">MTGGHFERKDAVGQGVKGTLIVGGVGAIMSGIQNSLSKQNIGAMGVITKTGATIGIFAAMGGSYMFVRNAAANLREKDDHWNPTIAGFVSGAVLGTRFRTMPAVLGYGAGLAVLLGTFDYTGGTLRGYFRDPDFDEITRKENIRKNRRRPFEETVEEIGEGRGIQGPGYEDRRRALLTEKYGIDFTNVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN00</accession>
    <name>U4LN00_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN00"/>
    <dbReference type="STRING" id="1076935.U4LN00"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWIQERC"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="251"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="57110" checksum="713F01D6F1E8C6B6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNQ7</accession>
    <name>U4LNQ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to COP9 signalosome complex subunit 3 acc. no. A6H7B5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNQ7"/>
    <dbReference type="STRING" id="1076935.U4LNQ7"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NHYHDLV"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="2">
        <location>
            <begin position="68"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="456" mass="51245" checksum="CC04784853CBF167" modified="2013-12-11" version="1">MEKIVETFASYPSERDLSEDQLRQQSNLILVNYIYPVPASQLAKNLSDGRSLLDVLNPEFNTLPYVFVLLMELYDTRQINYCQKEFRRLVESFCQYAEGTSRSIIAVKPLKKALLRTDSSLFSFMHTIFTRICLKAKCYRDAIQVLDIDIFDSPPSRSAKDADLRGFELLSHEVMEYYLYGAQLYMGVKNWRRAQDFLSQVIAFPGNACSAIQVEAYKKYILVGLILDGKIHLLPKCVSPSTARGLKSLAKPYEAFATAFKNADTENFRQEITLTRDVFWQEQNTGLAGQCIRAFQHMQIIALKETYVTLGVSDIARQDFNAEGTAGGMGDVERIILGMIERGEIDASLSQPTPGSADPQTTVQFDSEGVDEAHSLEALEQQIKRIVSLNNQVKAMDKKLTLTHEYQTYRANSATGGLRVPGKGHPMDVEMLDMGYGGGGWGDDDVDETVMDYDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQK0</accession>
    <name>U4LQK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQK0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3740" checksum="C7F9569D7BC832C9" modified="2013-12-11" version="1">MGITRSFMMRKKSDFQSRITFTRSWIFKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQK3</accession>
    <name>U4LQK3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQK3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="7796" checksum="D2A7B4DD608EEB02" modified="2013-12-11" version="1">MKKIPQSPSKSEGPKLAKSEAIFLIAVSLGESVKSLRYIVSDPGSLERAPGEPGLLRAPHAPMSPSLDKQHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQM3</accession>
    <name>U4LQM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQM3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="3084" checksum="7C32FD4FFF4B6158" modified="2013-12-11" version="1">MSDGRFRPTRTSIRTGRYQACLDGCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQX0</accession>
    <name>U4LQX0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Uncharacterized protein C106.17c acc. no. Q10341</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQX0"/>
    <dbReference type="STRING" id="1076935.U4LQX0"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMRFCQR"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="333"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="715" mass="78887" checksum="385359F65235F59D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR64</accession>
    <name>U4LR64_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat-containing protein YAR1 acc. no. P46683</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR64"/>
    <dbReference type="STRING" id="1076935.U4LR64"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EAENVGW"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="206" mass="22274" checksum="CCC7F900C04DB61F" modified="2013-12-11" version="1">MTTTYTPATLSEEQIDDLLYFARAGETDDFLKTLEDIKTATKSNGIEILLATRDEHSSNSVLHMTAANGHLELTKKILSILPAPPTPDAVPFELLSQKNSGGNTPLHWAALNGHLEVVKILVMAANADPTITNNVGHDAVYEAQLNDKNDVVDWLLKHCDGLEEVVAGDLGEAEGAEASGDAEEEVETIDMDDEEAAREKLKQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRY0</accession>
    <name>U4LRY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRY0"/>
    <dbReference type="STRING" id="1076935.U4LRY0"/>
    <dbReference type="eggNOG" id="ENOG502SFYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="330" mass="34882" checksum="1BEF35C2CE7D5C0F" modified="2013-12-11" version="1">MSSPTNTRHGSTPPFSAPRPVPGAFTSGSAGRNAPSGSPSYGTSPFSSQPYSTSGNSPRNAPFSTSPLPVGNSPRAPAALPASNSPRGTAPFPTSNSPRGSAPFPTSNSPRNPPYSTSPAHSPSYPPPSPHYTGPSSLHNYPSQSSLRGSQQSHPQYGQQSHQQSYPPPSPPPPPPFQPLFTLITPTASELAHPHPNVHYIFADDVDPTLDLPPANPQERVITVDMDFDANGRPYVKEAHSLSSDYQLVGAEVKEAPQMAWTGGDGGSMLVIEGVEGGLQGVKASMGVEELGRVFKERMEMLRRVVEFSKGAELGEQRLGDQSSGDQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRY4</accession>
    <name>U4LRY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936511">
        <property type="protein sequence ID" value="CCX34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRY4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6232" checksum="456EF822E4495A8C" modified="2013-12-11" version="1">MFLSVPESALVPLEEPPPQRARRMDEDVITGSSFVHDMNSGAAVSIQLIAYEFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS31</accession>
    <name>U4LS31_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative aminoacrylate hydrolase RutD acc. no. C5CN82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS31"/>
    <dbReference type="STRING" id="1076935.U4LS31"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MLTFRHG"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="328" mass="36913" checksum="B67945229E0F9CCA" modified="2013-12-11" version="1">MSHTLTLEELVRHPEITNVIVKHEPRRCGAAFVALERGGPISIAYEVYGNGPIHLVFIMGLNGPRIAWHRQIKYFGIDRGDQFTVLVFDNRGVGDSDAPWALKYSTSDMAKDTVELCDFLSWTKPKQLHVIGVSMGGMIAQELAYLIPDRVASLILQSTAAALVPTLPWHKHLLHRATMLMPKTLPQRLAAAQRNLFSPSWLVKPDDHGVFPTNADRYVAEELWRLNDLKPPVIQGFLLQGLAATWHYVGPDRLKTIGEKVDRIMVCTGTGDEMIEWGHSTRLVEGLRKGGNEVHYREWLGVGHVLSWEVEGEYNKMVEEFVTGAHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSU2</accession>
    <name>U4LSU2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-210 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSU2"/>
    <dbReference type="STRING" id="1076935.U4LSU2"/>
    <dbReference type="eggNOG" id="KOG2960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFPRIVV"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="323" mass="34855" checksum="ECB0BC96A5E566F5" modified="2013-12-11" version="1">MAPTFVENAAPVVPVVTKAVNAAAACLDTKTESAKKWENFSFASIRESTVSRAMTTRYFKDMYDYAESDVVIVGAGSCGLSAAYKLAKARPDLKIAIIEAMVSPGGGAWLGGQLFSAMVMRTSTNKAAESFLEEIGVPYETEDQYIVVKHAALFTSTLLSKVLQFPNVKLFNATSVEDLITRKDENGNLRMAGVVTNWTLVTMHHDDQSCMDPNTINAPVIISTTGHDGPTGAFSIKRLVSIGAYEKLGGMRGLDMKMAEDQIVKGTREVVPGMIIGGMELAEADGSCRMGPIFGSMALSGVRAAEIACEIIEERRKQNLQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT21</accession>
    <name>U4LT21_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Origin recognition complex subunit 6 acc. no. O74796</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT21"/>
    <dbReference type="STRING" id="1076935.U4LT21"/>
    <dbReference type="eggNOG" id="ENOG502SAT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="457" mass="48890" checksum="91642450D863991C" modified="2013-12-11" version="1">MNQIESCISSLLPTLPGNIPPELLDLSTSLLAQSRTRISNLKPTEEIARNYVCAHIACEKLKNTLDLPTIDPRPPLPKKQYHNLVLHFKASLARPDRSPAKQRSASSPSTARTDLFSPSRVSLAGSPNNLTNRSLLSSPNRFNRSPSPSKPVPTAATARAARLAREAAAGLPYRPEQDSPTKSIKSVRNVNHNPASNPEPTSPSRLKPGRPRISTGTIGVRAGAVGINGAPMAPMAPMAPMSPARYTDSIPGSPHSPAPMAPMAPMAPMASMSPGGYSSQPGAPAYVAPMAPMAPMAPMAPMAPMAPMSPAKLRGTGTMGEEDKKAERVKKEMESMRRAVEEERLNKVAPVKALPAVKGTPGRKRKVVEGPEPSASPAKAGRKRKAEPEAIKEVPKKKKVAQPRTAQPQTSGSAGGGRMIQAQVDYLSERRLKIYDAWKSRILERCDQIDRGDVAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTA3</accession>
    <name>U4LTA3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTA3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="1847" checksum="A51EAB247E85E1E0" modified="2013-12-11" version="1">MVLGLSSGSDSLTGGPGSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTC8</accession>
    <name>U4LTC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein SERAC1 acc. no. Q2TBM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTC8"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="395" mass="44490" checksum="FFA88C843FEE732C" modified="2013-12-11" version="1">MQDVLSARNYHAPPLLSTSVSLSRTAPQLITMENVPSNSDMCARPSGMPDRTIDESTPLPLRCRTFRLSEIPSDVTENQLTQHLDGLQVTGFNCVFGNTRVFSLAHHVSRQVATVSFHREPDQFQKCQADKMSYIWFRKHRVEGRAVPINVAIDCDFYRMTPQYKSPEAPRFDIIAVTGLSGHAYGSWKSPDQADVMWLRDMLPLDFPASRILSWGYYSSIKDAKTTTSIADIARNLLHDIQVIQIVKRPLIFFGHSLGRLVIKKAFVDAAKGNTEQENPLIRSRIGILFFGVASYGSDFLFTLENDFRICHGSMDGCIAVSLYETEDTNAVEVRQANCFVPSETLTEEENTGGKMGAIIWWSDPDGLQQISDMFSIRIQQPDCGFRRSFKDSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTL6</accession>
    <name>U4LTL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to 50S ribosomal protein L7Ae acc. no. Q8TV03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTL6"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="30432" checksum="902D1B71063BD2E2" modified="2013-12-11" version="1">MSSITTPEPAPQNPPSHRRLIRVLPLISTDLPNLDDYQLPGNIAQDPKGDEYNARWSRPINLGSASSSGDQKQKSDAYMNANFVIRWLDKVPDTPTSDDQGVEPSEFKTLTCSGYEVPGIPLVKGGKELEVVLKCVDMALGLSNSTGAYVHSVDIPEITSLLLGYDPAEGDRFLIVLADDSPWVKKISGIPELCDEVGVPYVFVPSGFHLGGSSKHGPESKTNAYNFCMLLHATLYPPHDTDEACYNQAFGAAWDVVRMMRARRMRARRGKDYENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUG8</accession>
    <name>U4LUG8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUG8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="341" mass="38894" checksum="3CCECE64A7DA83B2" modified="2013-12-11" version="1">MSILVTPLTDRIICQYCSQGSVQLSFNSSDKLLHHLNTHHRHHHHTCPCNPARSLPNDLEFRDHLKTCRLALSLSSTSRSHQQQLQPFAILSDSKLQCSICELEIPVFKFREFDGHMCNPSLDKIIMGCRRYNPQNISAISISAISSLSKMSAKKHQLLSETEQRQNKSLQFEMIFLKEDNNFSCGLCLEKGKEFTAWTSEKLGEHMRTIHPRPMDLLGMVRRCEEGGWVCVKCRAAGARIGWKFENDFEVKRHLSNCHKGVRWECKCLCGMTNFTGVEEFTDHLKNCPELEQMLQRRLRGIWDGKRFCGITTTRNNGRFTTQAVVASIVPAGVGGETLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUH0</accession>
    <name>U4LUH0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUH0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="7030" checksum="DF0CD1C429F4D446" modified="2013-12-11" version="1">MIPAPCHRLRFTNNEPNNNINWHYYKGQQSGYFPSLGHIVNSVFISPGYPIRHWYRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUN8</accession>
    <name>U4LUN8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Cellulose synthase catalytic subunit [UDP-forming] acc. no. P58932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUN8"/>
    <dbReference type="STRING" id="1076935.U4LUN8"/>
    <dbReference type="eggNOG" id="ENOG502S2M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YCPKEEP"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="421"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="744" mass="83029" checksum="808B14A2E8592279" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUU6</accession>
    <name>U4LUU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUU6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652408" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6392" checksum="E0E8C66CB6D49E98" modified="2013-12-11" version="1">MAIIALYALFTADVSARRYYDTLDTRLDASITLHDMAGCYFRLQFINLLCTDLPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUY7</accession>
    <name>U4LUY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to G patch domain-containing protein 1 acc. no. Q9DBM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUY7"/>
    <dbReference type="STRING" id="1076935.U4LUY7"/>
    <dbReference type="eggNOG" id="KOG2138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QLWQQHA"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="675" mass="73393" checksum="9FC369774876CE9A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVC0</accession>
    <name>U4LVC0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Osteoclast-stimulating factor 1 acc. no. Q5ZJJ9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVC0"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18981" checksum="0473488EE50024DB" modified="2013-12-11" version="1">MEQIALFIVPGSFEDEVDEDEDDGEDEDREDEDREEEEDEREDEDRKDRQEEENDDAMWDPKLDDLPLVDSAKFFEAAKSGDIETVNLAVMQEQIDINAIDKSDPKNMALMHACNEGHENIVKLLLGRADIQVNKCDKYGDSALKRSCVKVHINIVKLLLERKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVL2</accession>
    <name>U4LVL2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to DEHA2E24376p [Debaryomyces hansenii CBS767] acc. no. XP_002770542</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVL2"/>
    <dbReference type="STRING" id="1076935.U4LVL2"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651845" evidence="2">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="40808" checksum="23B757CF3978D149" modified="2013-12-11" version="1">MKFSLLCLSVVAIFDVALAHGPALSAAELQKRDTHLANARRSFSQCQGHLAKRSDLRREEFIRRHLGIGPLVKRQNPTPTQQRNIATGTNTQSPFTGVPTCVLAPESMQGPYYLPGELIRDDIRESQPGVDLLLDVQVYNARSCNVMENVMVDFWHANATGSYGGYRVEGTQGETWLRGLAATNNEGVAQITTKWPGHYNGRAVHIHIMASINGSIRTDGDKRTYDGGTHPFIGQLFFQMDTINDISKLKPYSDNQSPLTRNEDDSIFNDATGSVRGYNGLMDMKKIGDNLSDGVIAWISIGIDPGRDHDTGFPRSTGGGRGNSNDATTTIPVGGPSGTVAMVATTGVNRSGAQGLGDLGVAGRFAAAGIGAVLAAMMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVR7</accession>
    <name>U4LVR7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVR7"/>
    <dbReference type="STRING" id="1076935.U4LVR7"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="327" mass="37146" checksum="33FE0D15C804C853" modified="2013-12-11" version="1">MDTKMQDVGGSPPPSSIAVQDTSSINELDGWIGTLMQCKQLSEVDVQRLCEKAREILQDESNVQPVRCPVTVCGDIHGQFHDLMELFRIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVALKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKLFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDNIRALDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNQNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVY9</accession>
    <name>U4LVY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10660369at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13682" checksum="458E60334D8F5749" modified="2013-12-11" version="1">MKWKINVSELEALLSLWLFHFRKDRGKSDSPGKEQRTRILGPNTSALKRDLRWWMIDEFNRGINYEGGRFGDLDDMAMGFCGIQDQADDELQYPDKLSAEGNRGLKDRLSTSNSKAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYL1</accession>
    <name>U4LYL1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYL1"/>
    <dbReference type="STRING" id="1076935.U4LYL1"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FDEHNPE"/>
    <dbReference type="OrthoDB" id="5411678at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="44622" checksum="B9F1AA9E73A38A1E" modified="2013-12-11" version="1">MESNNATAPIQAPPVTQANTPSPSSAVPNVPTPTNNPTPPPLPATSASQSQSPSAPPPAPSSSTSSQPPPQPTPTPSTSETPSVQAPAPTSTSASPSTVDAVVTKTNNSTVTFFSTQIVPSNTAVPAPPVNPTSSQTIASDAANASNISSVDSGAGGQLNPTAKVVIAVVVPIVGVALIAIALLFFWKKRRRDKEMLAEQRRKEVEDYSFNPNSPAGAMMTAGANSSNGEDAPYNMSESVGYRGWGSTNGGRKVPMGASVGSAPAFSPVGMAYTENTYVDSNGYNGIAPSPGAPSTDGGMSNAPLINPSQGNRPGTADSGPTIGGVAGGIVGNGQGPKNADHEGIRRGISNASSNYSAMTVSDISDGNPPGPYDAQYYAADGGYDEGHNYSGPYQQYPDAAYVPPVIREVSARRNTQIETPASHHYPQQGNSGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTW2</accession>
    <name>U4KTW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Rpb7-binding protein seb1 acc. no. Q9UTE3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTW2"/>
    <dbReference type="STRING" id="1076935.U4KTW2"/>
    <dbReference type="eggNOG" id="KOG0132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GIVQTCI"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="541"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="788" mass="85840" checksum="A17AB12C28AB41CF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTY7</accession>
    <name>U4KTY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Acyl-coenzyme A thioesterase 13 acc. no. Q9NPJ3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTY7"/>
    <dbReference type="STRING" id="1076935.U4KTY7"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIFDICT"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="19079" checksum="68267F0884B871AF" modified="2013-12-11" version="1">MAPPRAKTTAGSKELRGVDLTVTDPIERVNQFLAFARSGEYDGFDHDLLATHLHLKDASTKGTVTFHFKVPAAYCNRMGNLHGGAAALIFDICTTCALVPISKPGYWQFAGVSAGLSVTYLRPAPLGNEVEVFCEVVNAGKRLATLRGEIRANGKVLMIAEHMKASIDPPLEPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUS8</accession>
    <name>U4KUS8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_04735</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUS8"/>
    <dbReference type="STRING" id="1076935.U4KUS8"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWLIPES"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="19">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="19">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="290"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX05148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="403" mass="45499" checksum="645617CD1DFD8844" modified="2013-12-11" version="1">MSRKPISQADIDKYWEIFSHHSQGNLKITGDQASSILRNSGLSDNQLAKIWDLADIDRDGDLDFEEFCVAMRLIYEIINGDLKTVPKTLPDWLIPESKLHLVRAKDALDNGGEEFERPEPEDDTPGLKNGFEWYMAPADKRKYEDIYMANSGTHGQIAFAALNELYDSIDVPDTEVTRAWNMVNPSKTTTIGKDQCIAFLHMLSNRHEGYRIPASIPASLRASFEQNKINYDIESVKPPQRASGPDRNTISGKKAAFGESYITRLGIGGASTYKHSGTDFSSTKDEDWEEVRLKRELADLEKQITDAEAAADKRRNRDRHGASGASTIALVKRELEQMLDYKRRELRNLDEGTGLEAGKSLKSVREDLDMVKEQVDALEGHLRRREAALQQVLAEVEDEKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVR0</accession>
    <name>U4KVR0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF5">
        <property type="entry name" value="C6 ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="600" mass="67797" checksum="C79B714377AFB0C8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXI0</accession>
    <name>U4KXI0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized THOC5 family protein acc. no. Q9USR5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06088</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935291">
        <property type="protein sequence ID" value="CCX06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXI0"/>
    <dbReference type="STRING" id="1076935.U4KXI0"/>
    <dbReference type="eggNOG" id="KOG2216">
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    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="216" mass="25065" checksum="C0D8972E287564AD" modified="2013-12-11" version="1">MTLLTPLSESTTITDPALLHCLTIASRTKALCHEIVTALEATSNTEPSEAALIDRSRKQKQLNGLIAQLKGLHRNAIMSSREAKEATAEARREVDRLHLQLQNLYYEQRHLRGEIKACRDFPHQYTSLPLISEEEFLELKPECKELGPHEMMIERLNNEKEVREELEKQRKELLSRKQALTMENKKRKDDLASLDEQLKKFIESSRPIQTTFQKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYI6</accession>
    <name>U4KYI6_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYI6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9999" checksum="627777F28C4AA8EF" modified="2013-12-11" version="1">MDRRDFVSKSLRASIWRWMRMWISWRGSLDQLVRTHVYTPALIIQDLIRPLSIIFDPLRRASTYFDILESSASSTPDHRHRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYQ0</accession>
    <name>U4KYQ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYQ0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="3390" checksum="0EDE09179EB4EA5D" modified="2013-12-11" version="1">MVEGRYLYSLFVHQDHNLSFLDYDWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYQ5</accession>
    <name>U4KYQ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to S1-like domain-containing protein C146.08c acc. no. Q9Y803</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYQ5"/>
    <dbReference type="STRING" id="1076935.U4KYQ5"/>
    <dbReference type="eggNOG" id="KOG2925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRKQSYW"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15488" checksum="4DE8399A739782B0" modified="2013-12-11" version="1">MPKKAPRRILSTIDDLTSAPPPNPLPPNLILARITQAQGKNLFTCTLPSGEAVLAELAPIFRGKAWLRRGGYVVIDTNAVERDNKIVGQISNVVRNEKEWRRMEYWPEEFAAKQVESDSESEEESNMGKLPPNSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZB0</accession>
    <name>U4KZB0_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_07374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZB0"/>
    <dbReference type="STRING" id="1076935.U4KZB0"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34120" checksum="4D1F2573616DD127" modified="2013-12-11" version="1">MAENDTADKPDAAGATDEKADISGIDAEFCQKKLRQFTEQKQKIKLKDFFTDEKLKALSPTALAMFKSLIDDGCSVERALKFMALTMYYIVVLIDNSDSMAFEENDYTYAREKGIVAIRLLNHEKKAKVEKLMPMIKYDGISMIGTQLEAKILKHYIYEPAKLEKPLLVVTITDGDGGKEDVLRKTLMACVSEMQSGQKKSEMGGNAVAFYFARVGNNKKAADLIQRLDKDKDIGDWLDVFPDRLEEINDEATKWDVLAKLLLGVLYHDIDKQDENAAKDDGTADAPKVDQDSSTDDDDDFNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZD6</accession>
    <name>U4KZD6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZD6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3795" checksum="955B4BF6A8DCB40D" modified="2013-12-11" version="1">MALQRFFCINSIGDSFIKYARIRLNEAIYFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZL5</accession>
    <name>U4KZL5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_07524</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZL5"/>
    <dbReference type="STRING" id="1076935.U4KZL5"/>
    <dbReference type="eggNOG" id="KOG1854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RLDHQMQ"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX07935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="669" mass="72256" checksum="51447D7D8B78C0D0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0R7</accession>
    <name>U4L0R7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935262">
        <property type="protein sequence ID" value="CCX05639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0R7"/>
    <dbReference type="STRING" id="1076935.U4L0R7"/>
    <dbReference type="eggNOG" id="ENOG502SANW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="558" mass="60085" checksum="A37F0A2984BF982F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2C0</accession>
    <name>U4L2C0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2C0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3760" checksum="BEED3BF6E721B718" modified="2013-12-11" version="1">MLPTLNLSIVFRISVSPYLHFLTVRRNAWSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L321</accession>
    <name>U4L321_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Probable transcription repressor protein RGM1 acc. no. Q00453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L321"/>
    <dbReference type="STRING" id="1076935.U4L321"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX06653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="668" mass="73278" checksum="74FDA4D982E34BBE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3D0</accession>
    <name>U4L3D0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3D0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12904" checksum="FA09396A0B9E5DA3" modified="2013-12-11" version="1">MFRILQSTSQPASEQGLVPDPQNASHPAQNSVPQPNHQYVHNYTLCTPQPLHIAEQFFGMIDENSSVEYRALVPIYDEVQAHDIPYPFRGDRAQEHNDDIKALCECGIINNMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3L8</accession>
    <name>U4L3L8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein BOI2 acc. no. P39969</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3L8"/>
    <dbReference type="STRING" id="1076935.U4L3L8"/>
    <dbReference type="eggNOG" id="ENOG502QSRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="678" mass="71940" checksum="C16A7F1F4E4BC727" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L409</accession>
    <name>U4L409_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Vacuolar protein sorting-associated protein 18 homolog acc. no. P59015</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L409"/>
    <dbReference type="STRING" id="1076935.U4L409"/>
    <dbReference type="eggNOG" id="KOG2034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WIQREKW"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="631"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="869"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="976" mass="110713" checksum="3692A97D86662CB9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4I0</accession>
    <name>U4L4I0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935656">
        <property type="protein sequence ID" value="CCX11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4I0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9494" checksum="42DB96252A503A4E" modified="2013-12-11" version="1">MGSFNPSAVELSILVTDRASQLCENCLRKLPVRNFEKGRPLLGGKNSAHQSCYASYRRYKIPSRANRIEEFTRRLQHPFATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Y5</accession>
    <name>U4L4Y5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized transporter C11D3.06 acc. no. Q10085</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Y5"/>
    <dbReference type="STRING" id="1076935.U4L4Y5"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EFWILLK"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="525" mass="56442" checksum="E3FB79B82CB69C62" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5F2</accession>
    <name>U4L5F2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935243">
        <property type="protein sequence ID" value="CCX05280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5F2"/>
    <dbReference type="OrthoDB" id="5507811at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="470" mass="52038" checksum="389B46AE50F21086" modified="2013-12-11" version="1">MTGQTTYANVVRDAATKTVPNVGVVGSSKPFSTRFVRRIKSSDALPRIPRPVSPRMIAPATRGISWAKAVCATDLQSIPESVDDFEILEKDSAPTIVEDFAPVDISMIAADEASDEVKSNPPPLVSPYEQLRATKQDVYKRGLQDNLTIYIEDASLENEKIKITVSLEHEMSLHEPQSRDIATPADDFVSSVDGTYRISGPLEPEGMSVEPADGSENLKEPDPGSNLSASIILAEDVAEDDNPLTREEHMVLYADLLSDSTPDDPKVLTNGRSDITANIDLSSSAPYFSLLRMMGSFINRAVQQVTTLEARHAILLSYAEIIGNQGRSNHDNGFGSPSTRYQRDAQGNVYIEDSNSSSGWTKVIDLGERIIKIDAERNAAYENANNKKFADEYDSMLATKMQYWSHVDIQNIEGIKEWLASRAYTLELEAMRVRIEIRDKSEGMKDIFGFVGTERKKIMAGLNQEVKMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5X0</accession>
    <name>U4L5X0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5X0"/>
    <dbReference type="STRING" id="1076935.U4L5X0"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651147" evidence="1">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="266" mass="29859" checksum="E1708CFB0E2210BE" modified="2013-12-11" version="1">MLNYKIRNFTRFLFIIVLSSTLQQLHLTMATTNHPRVNTATHPLILTRLYHRWIPRLAKEPTSTLLLITPLNRFLELRFSRTSTPLLLHATAGTYLRTATHGIRGYTISTADAENQVHTLHHQLNGDIMESGMLTDPVDGVEKGYEAVWRISEANPRLAVVMVLRQGGGMVVRVGAWCQGVMKIGNEVTAERWIRDRGGWRRVAKSGGGRLPCSIACLDRDEEGGEGGKYLRSARGLGFVVAKTLEQGDVVVVEGMEWRVVEKFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L640</accession>
    <name>U4L640_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UPF0676 protein C1494.01 acc. no. Q7LL04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935381">
        <property type="protein sequence ID" value="CCX07906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L640"/>
    <dbReference type="STRING" id="1076935.U4L640"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LMAWSDD"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="172"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="325" mass="37032" checksum="7CA227F76A8A81A1" modified="2013-12-11" version="1">MAISTSSPAVKQRPIRKISVHNFKERREEIARQIIDAAEKDGFFAIKGQESPSPKEIEEVFQISKRFFALPDDIKAQTPLKKAENAGWECRSQIRPSTGTPDQKQSIQLQYHRRNDNSWPTDEALLAEDKATLCRFMEKTHALSQEILSIFAEALGFPSDHFAKAHQVTLPDAQSTLRLLHYHDITGTQYPASYWRAGAHTDFDCMTMLFQRTGEDGLEVCPGREAHTSFARGDAWTPIEPITGEIVCNIGDMLMAWSDDRFKSLFHRVRCPKIGENQRDRYSIAYFNQANKNVVVQGPRGKYPPMTAHEYILSALQRNFSQLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L664</accession>
    <name>U4L664_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935693">
        <property type="protein sequence ID" value="CCX12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L664"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="318" mass="36037" checksum="17DDDBE0ACF41267" modified="2013-12-11" version="1">MSALISEIETENRRTSTTRKLVQELFRRRQRGRELALSLQQLHETTKILKYVKGRAESNLAKSKPVKQNATGFRQLSAPTPTPYETLFPTTPDRYTTKGHSPLFLADEDIIRLNVPNSQPHTFSLSIPGCGDGWELSTNDEFEYSNQLVPLNLVLKTITSDKKARTQLAIQVVRFALALPPNGRLWGLDDIYFPQFNGTDIQPVTTDAARPIIRCDTKDAQRNDVASSAGLGVIGIVLAEIWFGVQYKDFRRIKNTYDSHLLGYEHFEDMFSQGVDELYFDAVKCYIYPWASQDKGNLAGKKTLKLVLDDLVKYSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6F4</accession>
    <name>U4L6F4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Rho1 guanine nucleotide exchange factor 3 acc. no. Q9Y7U5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_05192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="257" mass="25238" checksum="489CCA253799C1FA" modified="2013-12-11" version="1">MFGSTSGSNNLFGGAGAGGGDKDKPAAGGFSFGAPASAPAAGTSLFGASTSTTPKTVFGASTATPPATTSLFGSSSTPTTAPPANNLFGASSKPAGTSLFGAPASSTPTTTPSTGLFGGATAGPTSTPAAAPPSTSLFGKPAGPSMFGTGTPSNVLGAFGAATSAAPAASNALFGKPAETTAPAATGSTLFGTPATTTATSTTPAPVFGTTVGHHCHRCLHPQHHPQHHRSRRKYSLRKAHWNYCPRRSQYSLRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4L842</accession>
    <name>U4L842_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_13137</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L842"/>
    <dbReference type="STRING" id="1076935.U4L842"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="69"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="481" mass="52652" checksum="51D2A0399AC52C6E" modified="2013-12-11" version="1">MANLGITTIGEAKEIRGMNLIAAHSHIRGLGIDTETLETRPASQGLVGQQKARKAAAVILQMVKEGKIAGRAVLLAGPPSTGKTAIAMAMAQSLGSDVPFTMLAASEIFSLEMSKTEALTQAFRRSIGVRIKEETEVIEGEVVEIQIDRSVTGGNKQGKLTLKTQDMETMYDLGTKMIESLSKEKVMAGDIISIDKSSGKITKLGRSFTKSRDYDAMGPDTKFIQCPEGEIQTRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEVRDQINTKVGEWKEEGKAEIVPGVLFIDEVHMLDIECFSYINRALESELAPIVIMASNRGNTTIRGTAYKSPHGLPLDFLDRVLIMPTYPYGPDEIREILSIRAQEEEVTLSPDALALLTKIAQETSLRYGSHLITAASLVASKRSQNKSASEVVQVADVQRSYQLFLDQNRSVKFLQEYEKRFIGEEGKVNFHPSIAVAAVPVGDSMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8K0</accession>
    <name>U4L8K0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_12745</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8K0"/>
    <dbReference type="STRING" id="1076935.U4L8K0"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX13152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="336" mass="35995" checksum="21659DD523A01D92" modified="2013-12-11" version="1">MVVKVGINGFGRIGRIVFRNAVEHEDIEIVAINDPFIDPVYAVYMLKYDSTHGVFKGEVSSKDGNLIVNGKTIKFFQERDPAAIQWGAAGADYVVESTGVFTTTEKASLHLKGGAKKVIISAPSADAPMFVCGVNLDKYSKDINVLSNASCTTNCLAPLAKVINDKFGIVEGLMTTVHSYTATQKTVDGPSAKDWRGGRTAAANIIPSSTGAAKAVGKVIPELNGKLTGMSMRVPTQNVSVVDLTVRLEKGASYDQIKEAIKEAAAGPLAGILAYTEDEVVSSDMNGNPASSIFDAKAGISLNDNFVKLVSWYDNEWGYSRRVLDLISYISKVDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8N3</accession>
    <name>U4L8N3_PYROM</name>
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        <submittedName>
            <fullName evidence="10">Similar to TPR and ankyrin repeat-containing protein 1 acc. no. Q8BV79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4L8N3"/>
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    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
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    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="461"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="1485"/>
            <end position="1513"/>
        </location>
    </feature>
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        <location>
            <begin position="1485"/>
            <end position="1513"/>
        </location>
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        <location>
            <begin position="145"/>
            <end position="177"/>
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        <location>
            <begin position="482"/>
            <end position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2132" mass="244639" checksum="8180F004CB88A39B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8P8</accession>
    <name>U4L8P8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Sentrin-specific protease 2 acc. no. Q5R7K7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935945">
        <property type="protein sequence ID" value="CCX14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L8P8"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915:SF6">
        <property type="entry name" value="CYSTEINE PROTEINASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="325"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="545" mass="61633" checksum="72401C8A9F6762A2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Q9</accession>
    <name>U4L8Q9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX14290.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="195" mass="22755" checksum="9E5FCD32834E02F5" modified="2013-12-11" version="1">MEKRIQQLEEENNRLNKDLTVAKEKPKTVPEINKKIEKLKEKKREMDMQKEFKSADQDGVSKDMAKVLKRYCKMEVQFGQMEKWIKKNMEALHAENGKRIKERLDECLEDNEKRMQEHEEKVQGQADHILPSARHIEQAAQKAVDAHAVVLGVTINEQGYFVRMTPMKDMPDDTIKITFGHGGVYLYVKRGKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L963</accession>
    <name>U4L963_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_01127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L963"/>
    <dbReference type="STRING" id="1076935.U4L963"/>
    <dbReference type="eggNOG" id="ENOG502RXZN">
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    </dbReference>
    <dbReference type="OMA" id="WTWEKLV"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="363" mass="41075" checksum="1068EBDBB6C0DE6D" modified="2013-12-11" version="1">MNDQYGRGRGQGKTTRGGARGGGDSFKWRRPTSIAATPPTVSDAKKLERLQRFASEPTVSRSAGSWRKPQEPTTPQEADLDDFGFVSKDRLKDLRNQELYHKHITRKYLEFCGTSGTSDQLEFEFAKLAITPLNNPKSTAAASKNIVYNDQRNAELSSILLGMRKLREGITAARRVDKFAIEVFKQHIRAAILVQQKDSYHPALTYLLYELHSYMPLSTLDIQEFGSYHMLHLAACMEEYGAALAVKNEFQIADQRALQALNGLIHGNYWSYRAARNRVDQYMGRLMDYAEDRMRKLALKSIGAAYFTVNLPYLEAVSGLPWEKLQEEYSVGWELDRAQGMVTVKRPKMKTKPAPMMSTGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9F6</accession>
    <name>U4L9F6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to DNA-binding protein REB1 acc. no. Q05950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936129">
        <property type="protein sequence ID" value="CCX15057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9F6"/>
    <dbReference type="STRING" id="1076935.U4L9F6"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSEMEET"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="483"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="487"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="535"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="803" mass="90619" checksum="F6F6513EB881B87C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9P5</accession>
    <name>U4L9P5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HF935540">
        <property type="protein sequence ID" value="CCX10412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9P5"/>
    <dbReference type="STRING" id="1076935.U4L9P5"/>
    <dbReference type="eggNOG" id="KOG3258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAINVRH"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="39"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX10412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="14528" checksum="3FFCA1AA74B5C749" modified="2013-12-11" version="1">MGKDSKPKAPTKGKAAAAGDAKKGDAKKGAAAEKTEKPATHVNVRHILCEKMSQIETAIERLNNGEGFDKVARDMSIDKARQGGSLGWKLRGDNVKDFSDAAFALPVSKVDKPVYTNPPIKTSHGYHLIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9S8</accession>
    <name>U4L9S8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to tRNA-specific adenosine deaminase-like protein 3 acc. no. Q6PAT0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9S8"/>
    <dbReference type="STRING" id="1076935.U4L9S8"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEPCVAC"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="226"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="48615" checksum="BA596A02FDB35DAD" modified="2013-12-11" version="1">MPPMECATLPANMVRPMSYPATPTAKLYRPVGKRFFIEPALPLVFPRRKRVAPMPPKPTGILHPLKTHAEIRSSLQTVNVYILPIPAKTANEVIAALREVVPQHELQHLRRLSKPAYIPASIAANLPPTQFPPEQSMLYIMVCQADRAPVQQIANIVAKTSPFQRKHGRPITPRPQVSIITVPANMPTSPEQSEEWTKKYWPTVYKRGNPFGPHPSLVENAAAKLTRASEYMAMARKVAREVADAGVGHACGAVIVNPDSGDVIAAAGDARLRNVEGRAWCNPLDHAVLRLVEMVAQKRLERGISVAPDNQIAALTETEAVFLNSNTMETLEGREEMKDKDKEKDHDKESAGYLCHNMQVYLTHEPCVMCSMALLHSRVGIVVFEHRMAKTGALFGDVGQGLGHGLFWRPDLNWKYLTWQWKENDGGTASEVPDDIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA84</accession>
    <name>U4LA84_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA84"/>
    <dbReference type="OrthoDB" id="5507421at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="631" mass="70107" checksum="6417677EFAE1ACB9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA86</accession>
    <name>U4LA86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA86"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3656" checksum="C5CA66C5EEBA6586" modified="2013-12-11" version="1">MSKDLNHCFRFVQASSTPSIPFFTCQNHLVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAA0</accession>
    <name>U4LAA0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX15011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAA0"/>
    <dbReference type="STRING" id="1076935.U4LAA0"/>
    <dbReference type="eggNOG" id="ENOG502SRAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WINQNAF"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="280" mass="31377" checksum="58912FC569BF864E" modified="2013-12-11" version="1">MAALTLVLEKSKGEEPWIVEQQIFDIINSYLQPTDGPSASQAAEQLSQLFPYHRPSSDAEKEEPASFLYELWGLVLKIAQQIQYQHPGQDKLVVLINTLRDLPSELKVPIWGSESRIWQDLPLLGPNLTEVAHTIGPEHDDRWVNFNAFCARLTRDGTCDRSAHAIWDLREALEEEPDQREEAAKEHGKQLDIRIPVAANWITIAGNVLYRHSGDCGKDGELGVASQGRLYSGQAGFSLERWAFWKERFGAIKVNEGVADGTKQAAEEAEIAMMKIENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB10</accession>
    <name>U4LB10_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX15600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB10"/>
    <dbReference type="STRING" id="1076935.U4LB10"/>
    <dbReference type="eggNOG" id="KOG1661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="248" mass="26943" checksum="4A6D9BF37E536820" modified="2013-12-11" version="1">MSWRCTGRSNAELVANLKRHGLIKTDAVQKAMEAIDRADYCPFEAYVDGPQHIGYDATISAPHMHAHAVETLAPFLKPGAKVLDVGSGSGYLCAVFGEMVKPNGLVVGIEHIPQLVNLSLANLQKSPPTSSILSTSPSNTVSSPSSTVIQILQSDGRLGHSESAPYDAIHVGAAAKGFPEELIKQLKAPGRMFVPVEEDDGGQGQRQPAQFIYVVDKDEEGNVTKTRRYGVMYVPLTDRKEFQEREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBG9</accession>
    <name>U4LBG9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBG9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9133" checksum="B3ECC66E3207B150" modified="2013-12-11" version="1">MLGRTRSSCCTPVYTTPSESTPPRAVESYLRRHQERWTQDTSVSWCRGLELSRNASYLSQDASYSILILSLTVQNLVSTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBM3</accession>
    <name>U4LBM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Tetratricopeptide repeat protein 1 acc. no. O42668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBM3"/>
    <dbReference type="STRING" id="1076935.U4LBM3"/>
    <dbReference type="eggNOG" id="KOG2002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EHWLTIA"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1164"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX16657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1181" mass="133854" checksum="842C1E386F19C254" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC28</accession>
    <name>U4LC28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PWWP domain-containing protein 3 acc. no. Q09842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC28"/>
    <dbReference type="STRING" id="1076935.U4LC28"/>
    <dbReference type="eggNOG" id="ENOG502S5RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPVIVCD"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="115"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
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        </location>
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            <end position="264"/>
        </location>
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            <end position="292"/>
        </location>
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            <end position="316"/>
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            <begin position="468"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX16350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="568" mass="61494" checksum="210A5476C09A14CA" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
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        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX11998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8558" checksum="D5477B8AE4A73860" modified="2013-12-11" version="1">MLIMLGAYVAAALLVAAALLVCCCFGCCSSCAAHSVSGLPNIPLLHRQKHPASPAATRLPRLPLRSCPHTHVRSCSSHGINN</sequence>
</entry>
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        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 100304</strain>
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        </source>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="568" mass="60831" checksum="089C3ECACEB29683" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LD34"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="191"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="413" mass="46717" checksum="FC86972F0F027B25" modified="2013-12-11" version="1">MALPPTTTTIQVPPLSSAPPEWNSDPAWKLPSWAEPIIVASILFGACYCTRRRNFSILNKSSNNNYTPLSLHDDDTSVVEPYSDTDSSSDYSLSTSTLKHPPRRRRWLWLTITTPNTSRFANNPHSRILHKFPFLLEMFYWILTYFLYRLTHILSQSLFSDSIWDTAQENALKILFVEQFSFLSFAFPVQEISVQKWFLAGHPLLLTVLNKAYALIHIPGTVFFMAWYYSAAPNHAVFAVVRRTMTLCNLLAFTIFMLYPCMPPRLLPKEFGFVDTVRRDSAESVFMNGKFVNHLAAMPSMHFGYSFIIGMTCLYHAGGFRWMGVGYQNYSGLGWRVALGVFGVAYPLGVLTVIVATANHYWLDAVAAAGTAAVALVGNRVFVVLVPLEDCLLWVLRVERPRHTTGEKEGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEI5</accession>
    <name>U4LEI5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Acyl-CoA synthetase family member 3, mitochondrial acc. no. Q4G176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEI5"/>
    <dbReference type="STRING" id="1076935.U4LEI5"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGKWFKT"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="477"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="593" mass="64896" checksum="00DCBA688EDAAB4D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF63</accession>
    <name>U4LF63_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_08707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF63"/>
    <dbReference type="STRING" id="1076935.U4LF63"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WCIYWIL"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="11">
        <location>
            <begin position="134"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX30508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="513" mass="56707" checksum="C56F600B0243B296" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF67</accession>
    <name>U4LF67_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF67"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="9812" checksum="77CB19220EE73420" modified="2013-12-11" version="1">MSSSSLPPELDLKSSSMLDRCYCRTGGHKVIVVVTITLVSRLLRRLSRGQILLLNSRSIQSFNPPLDVSYSAEKYSRLTCAGLSTLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG16</accession>
    <name>U4LG16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG16"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4961" checksum="5C9A3CDB04AA4937" modified="2013-12-11" version="1">MDRKPGEHNFDGSSLWFVVSFSAPQSAVDLIGKHNDIIVSMSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGB4</accession>
    <name>U4LGB4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936128">
        <property type="protein sequence ID" value="CCX15024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGB4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="126" mass="14656" checksum="A56E6E8FC70A2D40" modified="2013-12-11" version="1">MIRLIIKNPERVALVGKGIGSATAEQVGDAMESIARIQWAQMGRGFIGDGLRIGHLDVGVQRLVRLKMGFPKLKKENVENYEKMLRVPISWDWEIVKGINNRKKRFTDRVIRDQPWWGDCHWWTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGF7</accession>
    <name>U4LGF7_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
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            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="192" mass="21589" checksum="2EE2043C62FB5742" modified="2013-12-11" version="1">MDVDSIEEGLAIKKALVEGTTEDEEERPNAREKIKRIKGPNGGREKTEKRRLQREQKRLREGIDKESMRGIRAANPPVSNPFGHWNPKTEAKKRARENKKERGEDEAGYVAQGRDRSKEIIAVKIERDYGLEPSATPILITAIPRGSTVQGLVDFGIVKTALIQDLVFRTLNKSSRSPKTRSPSASYVLLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV2</accession>
    <name>U4LGV2_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
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    <dbReference type="OMA" id="PEIEMER"/>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
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        <location>
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            <begin position="425"/>
            <end position="457"/>
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            <end position="547"/>
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            <begin position="581"/>
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            <begin position="64"/>
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    </feature>
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        <location>
            <begin position="119"/>
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        </location>
    </feature>
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            <begin position="232"/>
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        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
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            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="628" mass="69207" checksum="46688106F19756B1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH32</accession>
    <name>U4LH32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized WD repeat-containing protein C12G12.01c acc. no. Q09866</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_10766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH32"/>
    <dbReference type="STRING" id="1076935.U4LH32"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WIGLCHE"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="2">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="508" mass="57503" checksum="BE055DC925744E9D" modified="2013-12-11" version="1">MTDINAVIKSRAERGYNMDCAKNIEIFRLEPNELLRNVWIWIYRAAQLADKNCMRAIHLDLSYLGVLGIWNSTSEPVPKVRINPTLGREVNLHDWGITCKEICRRMKLSEFKSCETAFPYQRRLCLAGLGCHFDPEDLEIECQRLEDLKEFGRAAGIAVFHGDLGRCVKALDAGDVETKLMASIVSAFWAMTEAGHMHTTKSSVWRARTVRFGNLLEDPFKRAIFAYISNSDWKEVLDDISLPLSERIGIALRWMTDGELKGYLNYWADTAIKDADLEGIVLLGLTPRLVDLFQRYIDRTGDIQTAALVMGFTTPRYFTDEKVEGWISNYKELLKSWKLLISKCKFNVMRSQNSRNGAGKITALIPKPQSFIRCTQCSERFNIGPGTKACTKCGAAMPRCAICLTRIGDPISQTRKDIMEKELQGRAKENVNLRAYMSHAMMRPAMDVKDKGKATDNKETFKASSGAWSFGPMEFALPNTRPPLPTPDEAAKKKRELQGHYQNCLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI06</accession>
    <name>U4LI06_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935654">
        <property type="protein sequence ID" value="CCX11904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI06"/>
    <dbReference type="OrthoDB" id="10643128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="825" mass="90573" checksum="E02A395C79EF7DF5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI35</accession>
    <name>U4LI35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI35"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9871" checksum="BD263138EE3EE7D6" modified="2013-12-11" version="1">MTVLYPIELRFWSEAMTVKILLRRSPTKRRIHSELGNVGSISVRSTADQVTSRGAQPSSESLVFIQHHSFLPSIFQTHPPFIIIPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIT9</accession>
    <name>U4LIT9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Aryl-alcohol dehydrogenase acc. no. P39849</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIT9"/>
    <dbReference type="STRING" id="1076935.U4LIT9"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSACKSC"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="40667" checksum="C15CA6991B60EB84" modified="2013-12-11" version="1">MTVQSALAIVSHPFTTTSEGKKETNWKLEPVTLPAPGPNEIVVEMIATGICHTDIALSLYPIPGETTPKSAVLGHEGSGYIRALGEGVTSHNIGDKVLLSFKYCKACEQCEEGHPAFCENFLPNLQGTDGYFTSSSGEAIKGQIFGQSSFASFSVVAESSAVNVTQLLNDEELKLCAPLGCGIQTGSGAIINIAKAGPKDRVVIMGLGGVGMSAIMAAKYMGCKTIIGIDRLQSRIDLALELGATHGINTSKMDAEKEVMEITSKKGATIVADTTGFEPLFDAAMRFLSRRGKMIIIGMCFGNYKFHADRLMTSGQRIIGCVEGDSIPSEYIPRMIQMYREGHLPFDRLVKEYPAADFQKALHAMEDGSVIKPILTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIX9</accession>
    <name>U4LIX9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CRAL-TRIO domain-containing protein C23B6.04c acc. no. Q9UU99</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936499">
        <property type="protein sequence ID" value="CCX16694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIX9"/>
    <dbReference type="STRING" id="1076935.U4LIX9"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIHARPC"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="150"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="347" mass="38379" checksum="98F695AAB668E1FA" modified="2013-12-11" version="1">MSTEAPPPTTEAAVSPIIDEKAAVPTTPAATEPIAAAPVAAATASSSTTAVDQPVADGKIRTPFNAPFPGSVLPPAADLTEPQKTAYDALLAHCNTIADLSDTEKCWLTKECLLRYLRASKWDVPTAKKRIEATLLWRKEYGVEKLTADYISNENETGKQVILGYDKESRPCLYLKPSEQNTEKSPKQIQHLVYMLERVVDLMPAGQETLALLINFKSSTKSSSPNINQGREVLGILQNHYPERLGRALCINLPWFVWGFFKVINPFIDPLTREKLKFNENLCDHVPAEQLDKDFGGKCDFVYDHTLFWPALTKMCDERRAAALQRWEALGSKIGTSEFEIKGGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJL3</accession>
    <name>U4LJL3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_05636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJL3"/>
    <dbReference type="STRING" id="1076935.U4LJL3"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHRFVRH"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="11">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="477"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="359"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
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            <end position="421"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX29565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="638" mass="73665" checksum="82BE4C8019DE22E5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJM7</accession>
    <name>U4LJM7_PYROM</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12691.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4615" checksum="33CA620B6197E1C6" modified="2013-12-11" version="1">MAFCLHVNARLVPLRGRFSRSFPNRLYRLEFALHELLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJU1</accession>
    <name>U4LJU1_PYROM</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_12976</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJU1"/>
    <dbReference type="STRING" id="1076935.U4LJU1"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHVMEYC"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF191">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="326"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="677" mass="75524" checksum="35A03C4B8E4123FA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJU5</accession>
    <name>U4LJU5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B wHTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935733">
        <property type="protein sequence ID" value="CCX32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJU5"/>
    <dbReference type="STRING" id="1076935.U4LJU5"/>
    <dbReference type="eggNOG" id="KOG4705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFQFICG"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="23522" checksum="9E3617F6FAAFA588" modified="2013-12-11" version="1">MAEHLPSSLEEEYVKKPLVRPVTEVTLATSKTATVEVKTEAKAEVKEEVTERMDVSMTGVTEVTAKIEEAKIAEIETQVTTQQTTDPVILQLLRLRVSFNFLSSLYLPVHITALLQVHLSTLHDFTKLDSYVEELKKLRTDAAAARQGDFSMKRQNMDEEIDGRAEKKRKLEEEEKKKAKNVSRGVKELSKVNTRGMAKITGFFKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKL0</accession>
    <name>U4LKL0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to eRF1 methyltransferase catalytic subunit MTQ2 acc. no. Q03920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKL0"/>
    <dbReference type="STRING" id="1076935.U4LKL0"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="230" mass="24685" checksum="69C9AA9EC9EA424D" modified="2013-12-11" version="1">MLPTPDTSHIDPDTTYEPNTDSYLILDSLTADAPFLSSRFKAPAPTPLILELGTGSGIISAFIASNPVTLFGRPDLLLLGTDANSIACAATNQSLKITPNPHLQLASVTADLATPIRPNEVDVLVFNPPYVPSPDVPKLGKHEDGYEEQFRLLALACDGGADGMEVTRRVFEGLGETLSARGVAYILFCASNKPDEVMEELQGKGWSCVKVGDLGKKGGIEKLTVWRIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKM0</accession>
    <name>U4LKM0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Probable E3 ubiquitin-protein ligase dma1 acc. no. Q10322</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKM0"/>
    <dbReference type="STRING" id="1076935.U4LKM0"/>
    <dbReference type="eggNOG" id="ENOG502RQI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="331"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="427" mass="48419" checksum="4A821B139F89E5F6" modified="2013-12-11" version="1">MADPLSIAASISGLISLSQQFTTVLYSFSTSALDARLSVRKLLAEIESLHTIFLQAQSLIHRPQLSFPSCEHLATMLTGCVLVYSDLERHICSFSSLSGVSNVSGAVLIWESLKWAIKEEEINSLVSDLERHKSNLMLLLGVITCESVTETQQALSELQSQMSLLLESNQQLRNMMKRRSSCSSIRGLTYEAILRTTRPYRPSHLWEENTNRFSQTTETKRSRWTWVSDLSTRASELSLFELPVYPEDLWNPEHYEFTRSTRTSRTSIYRTSIYRPLSTVITRQLSAKPAPLLVRSCRFTPTSDESDSPVASLPFSVSAQAWRYQPPDDPIIFGRGPIHNPVYGDEDTPWIAFQTEFVSKRHCEIWWRLEAGHTQWFVRDLGSANGTFLNGVKLIPEKVTRVRDGDLLRLGEHWKRSATQGEGSIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKY7</accession>
    <name>U4LKY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKY7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="202" mass="23547" checksum="49780C7E342504A4" modified="2013-12-11" version="1">MKRRFEAARPRLPAWVIKTRLLNSTWRLLEPYVFKKRLLAGEAPLADSPPLRLPVLSIRMAGDKIPLTKKFQTFFVDEQRRRQQRKLRPLPHADSISRLEERAWHPLFLEQPQCRTASDEDAWEIQVIRQFSRNLIDTESREIQVIRQSSKNMIGTESREIQVIRQSSKNMIGTESRELGDGYRAYCGPSNYPTHSYAPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLJ6</accession>
    <name>U4LLJ6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935851">
        <property type="protein sequence ID" value="CCX32452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLJ6"/>
    <dbReference type="eggNOG" id="ENOG502T21N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30705" checksum="74406E70C5A292B0" modified="2013-12-11" version="1">MGPISLASSVAGILGLTGKLAITISRFVASAQSAPQLATHAVNEINSLVTIFAQLKGLALQNSPARNFITVDQLVVVISGCVITLAELNKELEGLDDRDNMDVWERIKWVNREPTIKALVDRLGVHKSSLSLLLTTLLCHSMVQAEQFMGDLRAQISSLTKTNERLLALLERDNPSWSEKNSDAEPAGQLQATRFDFDETLATSYVYRGIPVHATAGSIMSRSTTKTCWTELSGLSLAQVDNIGDILLSLCREDIATSGRWFSTLQIEPTIMEEKELEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLQ6</accession>
    <name>U4LLQ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLQ6"/>
    <dbReference type="OrthoDB" id="10464722at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="15164" checksum="08D12C4835523A2A" modified="2013-12-11" version="1">MTTLSLNTMHIHAYNFALLVRLVLLIIGLVLLFENPRIVVYYIIPAAAALCALPKAWMWWKRQAGVTSVDPTELNLLINKNEALMERCSLLTLEIAYLRSENAKLAEINEIMEEGIFGAKSRGTKRRVRDFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMH7</accession>
    <name>U4LMH7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Alpha-galactosidase</fullName>
            <ecNumber evidence="4 13">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_01539</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4 13"/>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMH7"/>
    <dbReference type="STRING" id="1076935.U4LMH7"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SYNHYSC"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000008">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651583" description="Alpha-galactosidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="15">
        <location>
            <begin position="322"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="596" mass="65495" checksum="47744BD84CF2B2AE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNB7</accession>
    <name>U4LNB7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNB7"/>
    <dbReference type="OrthoDB" id="407106at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="430" mass="48771" checksum="75361B4BD36828EB" modified="2013-12-11" version="1">MTSFETPPRYPRMEMKPRLLVYRFIEELRDSSGQSIFVHTDYNERNEIIKKFCEIPCYLEETDNRQSLSKYPFVVRKFVGFDDEHKINVTFNDTSLHDYIASDHLDNGDNGQLISHSSRRLDGTQLWEIARFKWGFLVRPEKMSTMLRLFVLGFLQNVDIVSGPYLAAGLVADFVSLAFLRALAIPNTGFPLIGFTLDSSETIGSIRPNRSMLQNLFGLLFQAPKTSSYARGRELIRIGKQFGLKRFKWAEPGQNIAPWDIRPVYSTSSAVIHEIPDEVIDHEQYLASVVSVSPVVPDAVWTENPESLIEADLLPPTPMDLDICTISSPISDCTSKLSECNMDGTTGWYPVENCTTSPILVDDVVVPWTFDSTGLLMTHLMYPNNDVVLEALSPTSPQEDDGLSPQLPAKGYNRKDNLDKHWREKHIDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LND9</accession>
    <name>U4LND9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LND9"/>
    <dbReference type="OrthoDB" id="10400342at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651515" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18310" checksum="2383FCB1454D208C" modified="2013-12-11" version="1">MRLTIPVLAVALLSGLTTAAPANHSPTEGFEPVPTYVPDSSISSADTETILTTPHLGLSRPYQSPIRFVKEDQTPANTPKGQNEDGHIWLYYYKHPEMRFCYHRWAPPDVCYMLTFFNNVISSYWVNEGCCAFYEGGRCKHDTNSSKPVTVVIHASRKAKTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNS2</accession>
    <name>U4LNS2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
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        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
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        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
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            <begin position="38"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="599"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
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        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="480"/>
            <end position="501"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX16229.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="599" mass="63362" checksum="F24370FB286E718B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP86</accession>
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        <submittedName>
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        <name evidence="7" type="ORF">PCON_02229</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="8">CBS 100304</strain>
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        <property type="entry name" value="Plus3-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
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        <property type="entry name" value="PLUS3"/>
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="190"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="565" mass="63070" checksum="55A5354B7D055C48" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP91</accession>
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            <fullName evidence="8">Phosphoinositide phospholipase C</fullName>
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        <name evidence="13" type="ORF">PCON_01803</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="8"/>
    <dbReference type="EMBL" id="HF936182">
        <property type="protein sequence ID" value="CCX33765.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LP91"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
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            <begin position="430"/>
            <end position="465"/>
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        <location>
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        <location>
            <begin position="900"/>
            <end position="1054"/>
        </location>
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        <location>
            <begin position="1"/>
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        <location>
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        </location>
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        <location>
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            <end position="987"/>
        </location>
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        <location>
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            <end position="1184"/>
        </location>
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        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
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        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
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            <end position="1128"/>
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        <location>
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            <end position="1145"/>
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            <end position="1184"/>
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        </source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33765.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1184" mass="133046" checksum="2A655D2799E186F7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPB3</accession>
    <name>U4LPB3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to 4-carboxymuconolactone decarboxylase acc. no. P20370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01093</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
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        <property type="entry name" value="AhpD-like"/>
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        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="18143" checksum="BE769F443A0283A4" modified="2013-12-11" version="1">MRSPSHQLQYPSHIIVMSQTPTAEELAAAHATIYAAGIAMRRAVVGPAHVERSLANASEFSMPIQDLVTEACWGQIWTRPGLDRKIRSFINMAMLCALNRSPELALHVRGAVANGATEDEIREVLLQVAVYCGMPAGLEGTKVADRVLGEIRKENGQKETEKHKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPD6</accession>
    <name>U4LPD6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Importin subunit beta-3 acc. no. O74476</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPD6"/>
    <dbReference type="STRING" id="1076935.U4LPD6"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="361"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121179" checksum="4AB80732C6E93783" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPJ3</accession>
    <name>U4LPJ3_PYROM</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_10371</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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        <property type="protein sequence ID" value="CCX31240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPJ3"/>
    <dbReference type="STRING" id="1076935.U4LPJ3"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQFQGFS"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="202"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="458"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX31240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="540" mass="60167" checksum="55EFC299BCA20325" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQE4</accession>
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        </submittedName>
    </protein>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX31560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="1980" checksum="2847523BF5A53623" modified="2013-12-11" version="1">MKYLPESAAMREHTTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQG7</accession>
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    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936527">
        <property type="protein sequence ID" value="CCX34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="309"/>
        </location>
    </feature>
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            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="424" mass="45840" checksum="3B8BABF60B8EEFD1" modified="2013-12-11" version="1">MKATFYAVLAISLSHFTYGAPTPKADGVDYSDKTHYHSHYDSYQHGYNAHDGYNGHDEVDYTGMKGKGHGGVDYTGMKSKGHGGVDYTGMKGKNSYEEVGYTGMKGKSSHGGMMDGGDEGMGSHGGMGHGGMGHSAMGGGDMGGGGKGGLGGVGNLLKPVTGVLGGVLGKRDDKEYDDKKGQVWGNVNHHFGQYADKDSEKKKDEVEDEFHHQWNYYANKYGHGGKDQHYKRDLVDRGDKKGSSFLSGNHVHVDLEKREAVAGNVKGDNEKHDSYHDTDSDSDSDSDDEDDKHHGKHDGHKKNNGHKGKGNVNWNANGHNGEANWNTHGKGGNVDWNHDRKGGNVDWSHAGKGGHVNWNAGDSKGGVNWHKKRDEPHNGGVNWNSNGNHGGASWNANHGNGNVEWDHNGHSGIVDWMKWVGKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQW0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQW0"/>
    <dbReference type="OrthoDB" id="10297946at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="213" mass="23644" checksum="C20874C668FEF873" modified="2013-12-11" version="1">MAPISRSTVDALLNRIEALERDTVTRAEYDALIKRCDQLEADLAAARVQALAQQPINTDLDAVGEDDDESLPEDGITPPHPGSFTLMTPGPSKQTRQQLAAMTGLDYADKSQKIAIRGKIYHFALGKQVDFSNGFKAYDYGTVMYPLLESIRDYVNKDIMVGQGRKWTLEMTEKTVRVICQDRLRNKNAAIRRKRLRTAPRGGPAPVPVVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQY9</accession>
    <name>U4LQY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQY9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7361" checksum="AD81253EF25E7493" modified="2013-12-11" version="1">MTPACDVASAIFLASFIGLLHKPYRSQMKPIQANILRMQEHRFGFAVRIPLSKTWRLTESSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQZ3</accession>
    <name>U4LQZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized urease accessory protein UreF-like acc. no. O14016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQZ3"/>
    <dbReference type="STRING" id="1076935.U4LQZ3"/>
    <dbReference type="eggNOG" id="ENOG502REVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVGRHEK"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="26190" checksum="20D7B1529538F212" modified="2013-12-11" version="1">MSTSLHPLLLLSDSALPLGSFAFSSSLESFLAHASHGSNPHLQSHQRAPARELVSTFLAYSLLSVSTTVLPFVTAAYNSPDKAAELDDELDASTLCPVAKRASVSQGRALVGVWEKSLVALCPSIELQACVKAYKAAFRKPGEAQGHLPVAWGLICRAAGLGLADVQYIFVLNHAKAVLSAAVRLGAIGPYESQKILAGEETRRLLMEAVERGGRLGTEEVGQTVPAVDLWQGRHELLYSRVFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR32</accession>
    <name>U4LR32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936586">
        <property type="protein sequence ID" value="CCX34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR32"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="205" mass="21905" checksum="FBAFA4E6CC48A797" modified="2013-12-11" version="1">MSDLTFTDRKAIVESYIHANRDPVTVALTTFLGALDDLTIRALVNGIFNAVSAFNFADFRAVMLAWVMEHPFHTAFVVLGLILNINPLATAGFRALGPQAGTFAAAWQSHIGATVAKGSSFALLQSVGMVGASAIPAAGMVMIIAGVIRAAGIEDNEAIRDALQGAGRWVDKEIGGRVGLVLQDSRKSLLDWWKRNVEGRVQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR46</accession>
    <name>U4LR46_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_04156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LR46"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WETWYRL"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1722"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1811"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1722"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1822"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1843"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1859"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1894" mass="213048" checksum="D5B0BBFB745398A8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRB8</accession>
    <name>U4LRB8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Transcription factor ste11 acc. no. P36631</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRB8"/>
    <dbReference type="STRING" id="1076935.U4LRB8"/>
    <dbReference type="eggNOG" id="KOG0528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="204"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="555" mass="61584" checksum="7D40353F62214A27" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSD4</accession>
    <name>U4LSD4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YNL011C acc. no. P53980</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSD4"/>
    <dbReference type="STRING" id="1076935.U4LSD4"/>
    <dbReference type="eggNOG" id="ENOG502QUXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RITRIWY"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="493" mass="53398" checksum="322838300BFE65F9" modified="2013-12-11" version="1">MATRRRLVVLSGGSAANNLIDVFTTLCQDNGRGLDFIIPISDNGGSTSEILRVFGGPGIGDVRSRLVRLVPEETENSELQAIKRLLGHRLASCRQEARMEWLEIVEGTHKLWTGISSEKRELLRSFFNLINLEILKRSRPGSSFNFSTASTGNLFLTGARIFFGSFESAIYLFRSITGVPDNIQVIPAINSNFAHHIAAGLEDGTVITGQNQISHPSPPASGIPQVFFPPITPVTPSDSEAEEEEVEDANLPGSLAELRKQNIAFSKHDEAELTSRIERVWYINPYGQEIRPPANPKAISSLNHAEAVIYSIGSLYTSLAPILVLKNIAQAIKGCPSHTPKILLLNGSHDRETSPDCASFTGTSFVKAIVRAITGDPDTARWRDYVTHVIFLEGNGAPKVNIDELKARGVEPVRVYGRRHPDGEGKGMLYDSVPLLSALGAILGKARGRKPETRRNTVDGLQLANGAEKNGNGHGLGNVHGLGNARTVNGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSN9</accession>
    <name>U4LSN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSN9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="40454" checksum="3016A310AAC9D845" modified="2013-12-11" version="1">MADYNDYGFEMPFLPGQFEADCYHCKQQINDQRGWNHHCGCSIYHVPCFDKIYIAHCNKTNELQAKGYDISNMKVRCGECRNSVTFCSSQRPERREIDNHYYDKEPDDRRKNFIKINFAAIAHRNQRVNFQMDVESQYPRPGVDIVILNYGEARYWIKLFMEEKAKACTPITPEHLLYLAEAQEDSGLVAIRQQELEEYKLKEARKLKGKCKAKSEDEDEDEELAFLKRDEGKGVSMESQKIKPIIHQDTQPPPKFVPVKSPFNTPRAAVNNVIGKLGFVKSKDSQESLGTQQKSKGKARFEPVAGSSSRAGGSSDGGSSASQQPGVDVPEKMRGEADWDYMKRLEAWFVANGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT35</accession>
    <name>U4LT35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Probable DNA-binding protein SNT1 acc. no. P25357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LT35"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QQCIIHY"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX30966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LTP5"/>
    <dbReference type="eggNOG" id="KOG4039">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014843">
        <property type="entry name" value="Him1/Fmp52"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="25309" checksum="DAFD9DDA8E090859" modified="2013-12-11" version="1">MTYNATVIGSTGLVGSQILTRLLTTPSVTSVSTLIRRPSPHAIPQSTAHHETISSDTATWAATLPAILAAKNSSILFSGLGTTRGDAGSIEAQKKIDYDLNLALAKSAKKSGVKTYVLISSANAKANSWLPYVAMKGQLEDDVAALGFEKCVIVRPGLIVGSREKTRAMEQPLHYVANFMGAIAGPLKNVWAQDASAIAKAAIRAATEEGVWEGRKTVEGKNGGKVWFMGQGEIVELGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTQ1</accession>
    <name>U4LTQ1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTQ1"/>
    <dbReference type="STRING" id="1076935.U4LTQ1"/>
    <dbReference type="eggNOG" id="ENOG502S60G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72143" checksum="4BFBD24A4E011EB6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTR7</accession>
    <name>U4LTR7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pentatricopeptide repeat-containing protein At5g21222 acc. no. Q8S9D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_14086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LTR7"/>
    <dbReference type="eggNOG" id="KOG4197">
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    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="625"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="697"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="794" mass="90931" checksum="F53F2C86EF2E48B7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTY4</accession>
    <name>U4LTY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTY4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4956" checksum="72CC692C798D1159" modified="2013-12-11" version="1">MVLSLFIFRKSSLYFSGISGVIGFPKGILSRGSAGYVEKMFMFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUS0</accession>
    <name>U4LUS0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUS0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8962" checksum="BAD9347CBB42051E" modified="2013-12-11" version="1">MQRSSIHSEWRQYSAVLFYWQASGNGATPRIAIAGWSIRFITLGTAVLRFFNVQPDDLLLLYACIIDIRIRQCQEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUT2</accession>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4215" checksum="BA789D41C1A3B71A" modified="2013-12-11" version="1">MLTAINFAHSYSFLHTRFARIKITGITGMGITEMERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVF6</accession>
    <name>U4LVF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9204" checksum="57ACD99E9E1C122A" modified="2013-12-11" version="1">MLGIIPVVVYGQTLAFRFSFGRTGRPNQIHLALSTWYLVLGSEHWQATTQEKDSKLDQETPFTKGYDSSWRNGNVTVNIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVF7</accession>
    <name>U4LVF7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1304" mass="136872" checksum="3F579EAE1EF643A3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVQ9</accession>
    <name>U4LVQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_04294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVQ9"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="5263" checksum="D46EA89BC712F8A5" modified="2013-12-11" version="1">MLQQHLDILFVLYFSSIFHQVQPHNSKRHQDGLRILHQRRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVT8</accession>
    <name>U4LVT8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32821.1"/>
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    <dbReference type="eggNOG" id="ENOG502SA16">
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    <dbReference type="OrthoDB" id="5424021at2759"/>
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        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="14968" checksum="7C11C93085FE5881" modified="2013-12-11" version="1">MANVPQPPNIWQLMNYPIPRGKCVHKSSVISSGCPCLRFMLNPLQAASSFACDGCGHHASFHNLKNADEEGVGYVPEEKSMAIVTKPSKKRAASSASGRAINGNGLRKGLGFGLQELPTDTEEEEGAETEMVGVKRIRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYB0</accession>
    <name>U4LYB0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYB0"/>
    <dbReference type="STRING" id="1076935.U4LYB0"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CIPILEH"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="120"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="333" mass="37723" checksum="D1085CCA502E8DC1" modified="2013-12-11" version="1">MVSMSSNALFSVHDDVLALPQYEMKFPGDTFISSDEASAILTASSAVPFDSSDPQPTHQLMRLGGGTSDSVPREFLCTIPTVKPPPALNATEKELSKVEEEKELARATSRGWELLSDLEGKCLYFVSGWWSYSFCHNKEVKQFHQMPPQRDNQWPPMEDPETMSYVLGKVQEGEASVEGTELQATGELRYLVQKMGGGTVCDLTKKERKIEVQFHCNSHGPDRIDWIKEISICNYLMVIYTPRLCNDVTFLPSRENKANTISCTEILEKEQQEEFFRRKAKGELEAKKIMEEAEKELEAGGKKKKVEPLVEELKLIDMEELLNNLHLGDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYC3</accession>
    <name>U4LYC3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 16">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_04346</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LYC3"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATMSEFI"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652046" description="Vacuolar protein sorting/targeting protein 10" evidence="18">
        <location>
            <begin position="22"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1356"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1398"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="19">
        <location>
            <begin position="46"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="19">
        <location>
            <begin position="709"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1472" mass="165461" checksum="C0AF63E906294CC1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTU3</accession>
    <name>U4KTU3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Transcriptional regulatory protein DEP1 acc. no. P31385</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTU3"/>
    <dbReference type="STRING" id="1076935.U4KTU3"/>
    <dbReference type="eggNOG" id="ENOG502S14R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRRISMI"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="688" mass="76307" checksum="F795CF9A2BFF63C5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTV0</accession>
    <name>U4KTV0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Acetolactate synthase small subunit, mitochondrial acc. no. P25605</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935205">
        <property type="protein sequence ID" value="CCX04463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTV0"/>
    <dbReference type="STRING" id="1076935.U4KTV0"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CARSGMM"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32176" checksum="A58B74B741DB42AE" modified="2013-12-11" version="1">MAAPRAALRALTRAQPRLSRASSSSSTSAIAYKALHRRVKPLPTADTPSWSASAAVSSILYETPTPSATPAKRHVLNCLVQNEPGVLSRVSGILAARGFNIDSLVVCNTEVKDLSRMTIVLSGLDGVVEQARRQLEDLVPVWAVLDYSDAPLIQRELLLAKVSILGPEYFEELLAHHREMAAEGEAGEIAAAEKDFHPSKIAASMALRHKHEHLRAITDLTRQFGGKISDISDNSCIIELSAKPSRIDAYLKLVGQFGILESARTGLMALPRAPLAPGADELEVKEAEDVVDISNLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTX9</accession>
    <name>U4KTX9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935195">
        <property type="protein sequence ID" value="CCX04272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTX9"/>
    <dbReference type="eggNOG" id="ENOG502S06I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISPWIPC"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="286"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="483" mass="53062" checksum="12AB4E6BDD61B012" modified="2013-12-11" version="1">MAPLSTLRFHLHFPYLPALLLLFSELAELILTSPRIRLLEASICRRHYLAYDPSVIAPDGSIDEALCKLEDIQTRLAYIRGWQVFFEAIPVMALAVPWGALADRLGRKKVLAVNFVGCMMHICWFLLVCHPRSTMSAEWVWVSALAFALGGGPRTAGVLIMALVNDTSPSTERSERFYYTYSAFLVTELVAMPLASFMMSQSILLPFAVALISLIACFPILVSIRGVKRPTPPSPRRSSSDEANTGLLDPSPNPERSEHPSAPRTTIFTNLRTILAFLRPLLTNPSILLVLLGHFLCPVRQELLFQILIPYTSLRFSLPIASAGLLLSVVAFANLLIFLFGLPLATRYLRALEFSPAKIDAYTASYSSLILAVGSFLIGIAGVFPMLVISTLVFAAGFGIRLGLLSLLTSMVEQEMVGRVYTLVTVVEGAGEMVSAPVLQGMWAWGLRMGGGWKGAPWWAGAVVYVAGWWAIGRVKTVDTRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUG4</accession>
    <name>U4KUG4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_04042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="HF935220">
        <property type="protein sequence ID" value="CCX04923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUG4"/>
    <dbReference type="STRING" id="1076935.U4KUG4"/>
    <dbReference type="eggNOG" id="ENOG502S3AW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ILVGPPF"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005713194" description="cutinase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX04923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="213" mass="23136" checksum="C71206E0211CFE8B" modified="2013-12-11" version="1">MHLHHWILAITFLAVYAIASSIDNSTNTRNDLIDGECAPLVYLFARGTDEKGNIGNNVGPAFLNSLDDVFPADYIIAQGVQPYPATVAGYKAGGSPEGSEAMAQLIERADTQCPESEMILSCWSQGCQVLHNAVNLTSPEIYPKFAALVLFGDPDLNTTFPTGVSDRIVKEYCHELDPICHGIAKTNRAHDTYPEDADNAAQFVLDVYNQTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVI3</accession>
    <name>U4KVI3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_04894</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05307.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVI3"/>
    <dbReference type="STRING" id="1076935.U4KVI3"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX05307.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="563" mass="64287" checksum="F2B639BFA58FEC55" modified="2014-03-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW95</accession>
    <name>U4KW95_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04948</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW95"/>
    <dbReference type="STRING" id="1076935.U4KW95"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CRGRNGD"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="195"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX05361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="39273" checksum="3488CF1B100CAFE3" modified="2013-12-11" version="1">MSAPTEYKFSGWMGLDNESYKGQLVEGEYEVKPFEENDVDIKVSHCGICGSDLHTLRSGWGQTAYPCVVGHEIVGTAVKVGSSVKGIKVGDRVGVGAQSSSCLQADCEECAAGDESYCPRIVGTYGSKHKSGHKSFGGYADYARVPSHFVVQLSDISLSSEVLAPMMCGGVTVYSPLVRNGCGPGKRVGIVGLGGLGHFGVLFARALGADKVVAISRKASKRADALAMGADLYISTDEDPDWATTHAKSLDLIVSTVSGPNMPFAGYLQLLRTHGVFIQVGAPEDKLPAISAFSLIGRGLKVGGSLIGSPKEIRDMVELADKKGVKSWVNLWPMTKVNEALIKFEEGVPRYRFVLVNEKHAEMPDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWD4</accession>
    <name>U4KWD4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWD4"/>
    <dbReference type="STRING" id="1076935.U4KWD4"/>
    <dbReference type="eggNOG" id="ENOG502SB51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FIDETCE"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="151" mass="16899" checksum="E1044DE743B2587B" modified="2013-12-11" version="1">MSATSNPITPEAFQLAIQDLELELLHRESSRLQNSIYHLQRSNIALEEVKDDEDCAIAIRENVETIQRQQERVQMIRDEVERRGFSAPCGERKEEVDETHTRANGLAETNGVGEVTENGVSGSSTEANGVRQDPAVESGTREEEEEEGVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXE3</accession>
    <name>U4KXE3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_05722</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXE3"/>
    <dbReference type="STRING" id="1076935.U4KXE3"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAYSNRN"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="622"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
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        </source>
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        <source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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        </source>
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        <source>
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</entry>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
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        <property type="entry name" value="HIS_KIN"/>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="621"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="697"/>
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            <begin position="1037"/>
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            <position position="1098"/>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX04534.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1246" mass="139109" checksum="9FEC9C4025CB3495" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYE4</accession>
    <name>U4KYE4_PYROM</name>
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        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX06570.1"/>
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        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
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            <begin position="124"/>
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            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="24277" checksum="2F1450DFE914C8A0" modified="2013-12-11" version="1">MRSDKSDQSDQLTTSCRPNNWGEDLLPGLEDVAWGEDFTPEKIDWDDEPPEPESSWTIPLALDRMGLLDIPEWARNVDGTCSYNWAIQFQRADDDPSKIETSTTRNPDGSLKEEISKEEISKKESSKEICKHFAKKGKCKFGDKCRFSHEIVEEPPQDWELICRIRREAMEDKNGIPTKRCQFYDMAMCRRKYSCPNRHIDDDYDGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZB6</accession>
    <name>U4KZB6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_06990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZB6"/>
    <dbReference type="STRING" id="1076935.U4KZB6"/>
    <dbReference type="eggNOG" id="KOG2762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PERYGIH"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX07401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="429" mass="49051" checksum="BC225445750D750C" modified="2013-12-11" version="1">MDLLRDAWAFAFNSRSKFPSWIIPPLLLADALLSTAVVLKVPYTEIDWKAYMEQVTQYLGGERNYALIKGGTGPLVYPAGHVYIYSWLYRLTDNGTNILRAQWIFVGLYLATLYVVLLCYREARAPPYILPLLLLSKRLHSIYMLRLFNDPFAIFFLFLAILLWQKRMWTLGSMTYSLSVGVKMNTLLVLPAVGAILLQAVGRDKALRQAMIMAQVQFLLATGFLMEYPRSYIAGAFEFTRQFFYKWTVNWRFVSEETFLSKEFSLGLLAVHLSLLAIFLVTKWRKPSQRSFPGFLQLILSPPVELEDRQIAARVTPRYILCTILSANTIGMLCARSLHYQFYSWLAWGAPYVLWQAGLGPAFIFPLWAAQEWGWNIFPSTNESSGVVVGVLALSVLGLLWGVKNVEEPIHVEDRKVKKTKVKAEKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L024</accession>
    <name>U4L024_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="120" mass="13336" checksum="5CC21BBE1278A2B0" modified="2013-12-11" version="1">MPHAPFTIPLKRSNTVIHHKPTHPPPEEMPVILTLSAMVTACLSLPFIILATTPNGHNGRTPSRRSLPRREVVRTIVENAKRQGGELEKTDDKFENSSEETIKPLRRTATDDTLVAGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L060</accession>
    <name>U4L060_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L060"/>
    <dbReference type="STRING" id="1076935.U4L060"/>
    <dbReference type="eggNOG" id="KOG1437">
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    </dbReference>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651202" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="542"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="542" mass="58947" checksum="B2327014B5EBA61C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L063</accession>
    <name>U4L063_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L063"/>
    <dbReference type="STRING" id="1076935.U4L063"/>
    <dbReference type="eggNOG" id="ENOG502S55E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMEKDDF"/>
    <dbReference type="OrthoDB" id="5354458at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056687">
        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25009">
        <property type="entry name" value="DUF7785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="3">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="2">
        <location>
            <begin position="506"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="843" mass="92654" checksum="6A21A75FA0BADDCB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L064</accession>
    <name>U4L064_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Delta(12) fatty acid desaturase acc. no. P59668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L064"/>
    <dbReference type="STRING" id="1076935.U4L064"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="126"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="498" mass="55417" checksum="E73C1747B017843A" modified="2013-12-11" version="1">MSDSPMTRSRARRSGSISAASTPLTASTSASVTASMNSSSTSLSSMGDETKGKPLLDTYGNEFQIPDFTIKDIRDAIPKHCFKRSAIRSLSYVARDLALLAGTFWGMQNYVVPAIAGQSTLVRGAAWAVYGFTQGLFGTGIWVLAHECGHQAFSESKILNDTVGWILHSSLLVPYFSWKISHGKHHHSTGNLEKDMVFVPKTRTEYLRRYAGGIAHDVAELTEETPIATLTHSIAQQLVGWILYLFTNVTGHNYHHRQKEGRGVGKKNGYFGGVSHFNPSSPLYEAKDAKLIVLSDIGIALMGYALYAASQKFGAFNVFLWYGIPYLWVNHWLVAITFLQHTDPSLPHYNPETWNYCRGAAATIDREFGFIGRHLMHGIVETHVLHHFIPLIPFYHADEASEAIKKVMGRHYRSDTRGGAIGFIKALWTSARWCQWVEPSDGAEGEGKGVLFFRNRNGLGVKPLPKEKFVHREKEIENMIAVGVLKKEDVEKAGIKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0L7</accession>
    <name>U4L0L7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0L7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="10806" checksum="2A5CC056BEF75CBB" modified="2013-12-11" version="1">MEKKDNLEEVVCKNGLDEMIDSLITLNVRYRIEVVSTPAGYWMAKKSKVSVGSSALTSGTAALVRGNIAGSNRRTSKKTLPAFSNARRCETPFHCTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0N6</accession>
    <name>U4L0N6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Golgin IMH1 acc. no. Q75AF5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0N6"/>
    <dbReference type="STRING" id="1076935.U4L0N6"/>
    <dbReference type="eggNOG" id="ENOG502S0A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIGQDHV"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="1181"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138591" checksum="AC53B923C3794E39" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L103</accession>
    <name>U4L103_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to UPF0183 protein At3g51130 acc. no. Q9SD33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L103"/>
    <dbReference type="STRING" id="1076935.U4L103"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="49093" checksum="22DEA513D0D80DF9" modified="2013-12-11" version="1">MATAPGAPAICNPGKSLGFIALGSSLHHILGRLRTLNKVFTSISTIYEPGSPLGAPVIILLSNNGIRLRFDGADQRLRLIEILDFQLCPLLYNSRDMVKTGPGCSGGPTFKSIYNKIFGPTYPGEYIASSSLYVLSYPGVAFSFPVKNWRDDIPFDQQLSAPDASSAVSMAIFNGSSWAEARDDLFTRPVAAPRIPHINGPNARQSPANDEVESIKIHDSTLIEVLRRHNPSFWITLGSTTPQDLIMELGPPDVIYRKSDHRLSIHRAGDGDEAAGASDPHSSSDDDHDASGSAGAALGQGDCFYNYFSLGFDVFLSASKSASHPVATKIIIHGNVPGSYLFQRYRRCRWVIQWPGMEEIHSEMEFGEALERLRKRFGGGQKPMPLSRGNDSPSSSCELLGGWEEGDMPVLKQIAGGVEMRDFGNTELYGFPGFIFEVLKNKSISCLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1A4</accession>
    <name>U4L1A4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protoporphyrin uptake protein 1 acc. no. P40100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02783</name>
        <name evidence="6" type="ORF">PCON_05446</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <strain evidence="6">CBS100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF936346">
        <property type="protein sequence ID" value="CCX16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1A4"/>
    <dbReference type="STRING" id="1076935.U4L1A4"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYETPNW"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="285" mass="31617" checksum="290AEE6E9736FF54" modified="2013-12-11" version="1">MAESNDVGFVYYRYTPSLVAAVIFSACFFIVSFIHVWKIIRTKTWYFIPMLIGSLMEALGYIGRAQSHSQPRTLGPYILQSLLLLIAPALFAASIYMILGRLILVLSASHHSPIPIRWLTKLFVLGDVISFMMQSAGGGIMASGTLESMKKGEKIVIGGLFVQVLFFAVFVVVAIVFNVRINKEPTVESSTIQRGGRNGWGTLLNTLYWASGAILVRSVFRVVEYVQGNNGYLMRNEAWLYVFDGVLMLGVIAVFCWVHPSGAVPGDVKKRTKRGGYNDVEMRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1W3</accession>
    <name>U4L1W3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Transcriptional activator HAP5 acc. no. Q02516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_09234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1W3"/>
    <dbReference type="STRING" id="1076935.U4L1W3"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DNHDYKL"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX09641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="34229" checksum="3868804F3EE2E529" modified="2013-12-11" version="1">MDPANFPGPGRHDAMQQQQQQTQPYDISVMGHYGASAALVANASVPQSETIYSGTFANVSQGLHGHYREILTAYWQQTINTLENEDHDYKVHQLPLARIKKVMKADPDVKMISAEAPILFAKGCDIFITELTMRAWIHAEENKRRTLQRSDIASALTKSDMFDFLIDIVPREEAAPKRPSGGASASTSRPQQPPPPPPPAQTNQPPQQSGHHNTQQLGAPEYGMHPGMPDTDRYQAPMYGQSAVAQPQPGYPHQLYSEGLDNMYGYPPIPTQTMYQMPNQQAHLQDNARPEQGDEDADAEGERDYEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1W8</accession>
    <name>U4L1W8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_09239</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935478">
        <property type="protein sequence ID" value="CCX09646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1W8"/>
    <dbReference type="STRING" id="1076935.U4L1W8"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="213"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX09646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="306" mass="33252" checksum="E48CE40CDBA34B52" modified="2013-12-11" version="1">MATEKKQSNFLIDFMMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKQGRLDRKYAGIGDCFKRTMADEGLVSLWRGNTANVIRYFPTQALNFAFRDKFKSMFGYKKERDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDNKSAKTGGERQYKGLVDVYKKTIASDGIAGLYRGFGPSVLGIVVYRGLYFGMYDSIKPVVLTGKLEGNFLASFALGWCVTTGAGIASYPLDTVRRRMMMTSGEAVKYKSSMHAFSSIVKAEGVSSLFKGAGANILRGVAGAGVLSLYDQVQLLLFGKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1X7</accession>
    <name>U4L1X7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Integral membrane protein sed5 acc. no. O13644</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_09249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935478">
        <property type="protein sequence ID" value="CCX09656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1X7"/>
    <dbReference type="STRING" id="1076935.U4L1X7"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="236"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX09656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="328" mass="35688" checksum="A96494244B3EFC7C" modified="2013-12-11" version="1">MLLHSSTMSIQDRTAEFHTLTSAVKKRLRTPGQQQRLLSEPSNAVTKHSRGEFARRAATIGKSITDTMGKLERLAQLAKRKALFDDKPVEIAELTYVIKQDLGAINSQISSLQTFVRSGQQGVSSSSAAQEHSKNVVVMLQGKLADVSVGFKDVLETRTKNIQASRARTEQFVSGVRPVTPVPNALASHSPLYHTPSGTPGPQGGNGGGDLLLSIDPPQQSAQQLMLMEEGAGGQGSYIQARGQAIEAIETTINELGGIFGQLAQMVSEQKEMIQRIDHETEDVVANIEGGQRELLKYFASVSNNRWLMAKMFGVLMIFFLLWVLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L210</accession>
    <name>U4L210_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935519">
        <property type="protein sequence ID" value="CCX10175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L210"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651046" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6753" checksum="E7AA02F5C8D66820" modified="2013-12-11" version="1">MIRSSLLLALPGFARLLLPENTLPRASIDNSRSLGHNHNKQLGSASHSRKHHNFILISSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L240</accession>
    <name>U4L240_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935522">
        <property type="protein sequence ID" value="CCX10215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L240"/>
    <dbReference type="STRING" id="1076935.U4L240"/>
    <dbReference type="eggNOG" id="ENOG502SX9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DSHEMWL"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX10215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="211" mass="23697" checksum="ABD7D19064ECA9CE" modified="2013-12-11" version="1">MPSLFSERISEASFMLSVSLDGDEVDILVDTKFLGITPVYSGKDPNIDIVAVPGLGSHAFGTWKGDSHEMWLRDFLPKEPVLKDRLRVLIFGYDSALQKNSSTNSFGDYARNMLCVLNVFRSHEKERNRPLIFVCHCLGGILVKTVSSTRSKSAPRKSSLISTRYCAMQLMALMEIERYSSLVLGYSFSVYQTRVLIMQTCVVGEKLEQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2T1</accession>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="3075" checksum="4632E7D376331783" modified="2013-12-11" version="1">MQWYKPLSPKRPLILRTISNRNPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L310</accession>
    <name>U4L310_PYROM</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">PCON_09338</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="15"/>
            <end position="33"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX09745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="123" mass="13878" checksum="13FC396AA124606F" modified="2013-12-11" version="1">MLLPFRDPATLPRPSVSNSRVKSNSLHSPTPSLTLPNLRACFEQLRPPSTTSYHFSTLFHSLLHHLKLSHIFPHLPTPCCTLAQDNGTHSTEGTSTRTVTYKHAHNYSYTMGSNTNQRKRKPE</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX06953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4378" checksum="A599B2949D73D780" modified="2013-12-11" version="1">MYNQEDDKPPDRRWMANLITKSATVLHERKPAKPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4L5</accession>
    <name>U4L4L5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to ankyrin [Exophiala dermatitidis NIH/UT8656] acc. no. EHY59712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04110</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4L4L5"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="238" mass="26562" checksum="8E705EC95AAA0E4C" modified="2013-12-11" version="1">MDHLSLSASVAGLVSLALEVRRILDSYVSGVKSASDDVRRLFAEISVLCYFLEKLVEFQRSDDSNGISFDQTSIICSAATIYQAEVEKLYKKLEKLNIRGANGNKITEIIEKIKWPLLQEECEKSVASLQRFAQTFQFALVLENCKRLSKTPSEVLSQLEGKHREMETTGSTLKGMLVPVPDQVAKMADEITAVLQVVSEISQLGGKIDNISRGIDRLEDSLKGKDVCPIENRRYCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4R7</accession>
    <name>U4L4R7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Putative ankyrin repeat protein L93 acc. no. Q5UPG5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11651</name>
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    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4L4R7"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="255"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="544"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="716"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="783"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="849"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX12057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="924" mass="105627" checksum="CE71BA08A1AD9BE0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4S2</accession>
    <name>U4L4S2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_04529</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L4S2"/>
    <dbReference type="eggNOG" id="KOG0392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYSDIAC"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="1351"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1701"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="733"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX05040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1925" mass="213458" checksum="893CAAEFBE2F2C14" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Z1</accession>
    <name>U4L4Z1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Centromere protein S acc. no. Q9D084</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Z1"/>
    <dbReference type="STRING" id="1076935.U4L4Z1"/>
    <dbReference type="eggNOG" id="ENOG502S7WI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WTQIENV"/>
    <dbReference type="OrthoDB" id="1872155at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="112" mass="12539" checksum="CD92327925CA46E2" modified="2013-12-11" version="1">MSDDESAVHRERLKSALWYTIGKAVDNVGVELDVNATPQFIGALTEMVFSQVELVAKDLESFANHAGRTTVSTDDVLLLTRRNQALGEIIKEKVEEEARKRGDKEKPVKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L563</accession>
    <name>U4L563_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L563"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4433" checksum="859691E2BF211383" modified="2013-12-11" version="1">MAGSCMASPKIIQRASDVKCCSSFVWQAKRNRLNDDMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5C1</accession>
    <name>U4L5C1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Capsid protein F acc. no. P03641</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the microviridae F protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935241">
        <property type="protein sequence ID" value="CCX05245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5C1"/>
    <dbReference type="STRING" id="1076935.U4L5C1"/>
    <dbReference type="OrthoDB" id="5272594at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.169.10">
        <property type="entry name" value="Microviridae F protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016184">
        <property type="entry name" value="Capsid/spike_ssDNA_virus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003514">
        <property type="entry name" value="Microviridae_protein_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037002">
        <property type="entry name" value="Microviridae_protein_F_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02305">
        <property type="entry name" value="Phage_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88645">
        <property type="entry name" value="ssDNA viruses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="287" mass="32880" checksum="8DF87F8CF2709D3B" modified="2013-12-11" version="1">MPDRTEANPNELNQDDARYGFRCCHLKNIWTAPLPPETELSRQMTTSTTSIDIMGLQAAYANLHTDQERDYFMQRYHDVISSFGGKTSYDADNRPLLVMRSNLWASGYDVDGTDQTSLGQFSGRVQQTYKHSVPRFFVPEHGTMFTLALVRFPPTATKEIQYLNAKGALTYTDIAGDPVLYGNLPPREISMKDVFRSGDSSKKFKIAEGQWYRYAPSYVSPAYHLLEGFPFIQEPPSGDLQERVLIRHHDYDQCFQSVQLLQWNSQVKFNVTVYRNLPTTRDSIMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6K1</accession>
    <name>U4L6K1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Far upstream element-binding protein 2 acc. no. Q92945</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_05242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935264">
        <property type="protein sequence ID" value="CCX05655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6K1"/>
    <dbReference type="STRING" id="1076935.U4L6K1"/>
    <dbReference type="eggNOG" id="KOG1676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QNTTGCK"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="198"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="321"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="424"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="622" mass="65209" checksum="29CB4C1881778E81" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7X3</accession>
    <name>U4L7X3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7X3"/>
    <dbReference type="STRING" id="1076935.U4L7X3"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGWVNIH"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="331" mass="34434" checksum="1795D205A5AE7E3E" modified="2013-12-11" version="1">MTKLDTSAVVPQLPWVKTPLLKSSALSKLAGCEVYLKLDLLQPSGSFKSRGVGNLILKSLSSNSNRHIYSSSGGNAGLAAVSASVSLGTSCTVCVPTATSEFMKSKILVAGATSVITHGASWVEADSMTRKLLKADPTGVYCSPFDHPDIWEGNSTIVDECVEQLGGGVPDVMIASVGGGGLFLGLAQGLRRHGGSGKTIVAVETEGAESLAESLKAGKLVTLPGISSIATSLGARTVAEKAFEEAQRSEVRSAVVSDAAAARACIRFADEERMLIEVACGASLAVLYETGLKNLVPELTPESKVVVVVCGGNNTSLEILEKYKQEYALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8G2</accession>
    <name>U4L8G2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935289">
        <property type="protein sequence ID" value="CCX06434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8G2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2561" checksum="FDC16B532B35319F" modified="2013-12-11" version="1">MSIVLNHMISWRIYAVGKKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8L5</accession>
    <name>U4L8L5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="HF935487">
        <property type="protein sequence ID" value="CCX09688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8L5"/>
    <dbReference type="STRING" id="1076935.U4L8L5"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX09688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="496" mass="54619" checksum="88B9DE3A36D5899E" modified="2013-12-11" version="1">MSYRCARGIKLRIPSEPTAMFRLPIRCLGRQTPRIVPRVIQRLPVWRFNSTTASSTPSAQQSTQQQPAQQPAQKAESTPPSEEPKPKPQRTYSTPLAKFLTEAIKTTGPIPLAQFMRQCLTSDIGYYTSESDPFGRKGDFITSPEISQLFGEMLGIWIVSEWMAQGRKDKIQLIELGPGRGTLMDDVLRTLSQFRPLASAITSVHLVEASETLRVTQAQLLCNSTTFTENADGSLSCISKYNGIPITWHPLLSKVPKCSSPFFLAHEFFDALPIHAFEATKNGWRELLVSPDDSATAENNKPEFILSRADKSTPHSMMLPELSERYKRLSKVEGSIIEISPESLTITEEIAKRIGGPKAGGALFVDYGPLDTIPINSLRGIRHHEMVSPFANAGEVDVSADVDFFALAERALDASEGVEVHGPVEQGAFLLTMGMRERMEQLARGVEEEKKKEMETGVQRLTERGGGAMGKVYKVLSIVPERGGQRPVGFGGGLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Y4</accession>
    <name>U4L8Y4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Y4"/>
    <dbReference type="STRING" id="1076935.U4L8Y4"/>
    <dbReference type="eggNOG" id="ENOG502S13H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHEHENI"/>
    <dbReference type="OrthoDB" id="5429395at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="376"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="548" mass="60297" checksum="F1895400EC9B2EF6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L919</accession>
    <name>U4L919_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to integral membrane protein [Aspergillus kawachii IFO 4308] acc. no. GAA89824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX14380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L919"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX14380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="346" mass="38930" checksum="7B95378DBE8A6EAD" modified="2013-12-11" version="1">MLAYLLELSILALSILTVAGRIYARIRILRAIGVDDWFIIAATGGFILQTTLHLVMTRFGAGRHMTDIPASTYPPRFILAGVVRLLYIPTSALVRISVLLFMRRLSPHRIIQYAAFILITLTSVTAVSLLVLLVFQCSPPSIFFIPVPLRPPHECLIQEQHLSFVVPLASVILDFLVWIVPLVMIVRLQFVDWKKKLVLIILLGLGLLACIASFMRLEMVYHINSDQSWQGAKMCIWNCVELGIAITAASIPSLAPLIGIFSAHIRTKYRGVGNNNDEEQHLSRSEPLRSPRVQEVGLEDLHYDNRIRESGLDSPRRMPNYKSTEALFNEAKMGRRRADSVIPENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAB3</accession>
    <name>U4LAB3_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936128">
        <property type="protein sequence ID" value="CCX15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAB3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2594" checksum="99694E7B91ECA678" modified="2013-12-11" version="1">MRSVIGRYIGQIPLVDNITVVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAD6</accession>
    <name>U4LAD6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Acetamidase regulatory protein acc. no. Q06157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="262"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
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            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="553" mass="62879" checksum="F55DB3071E42B0CF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAN0</accession>
    <name>U4LAN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935343">
        <property type="protein sequence ID" value="CCX07219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAN0"/>
    <dbReference type="STRING" id="1076935.U4LAN0"/>
    <dbReference type="eggNOG" id="ENOG502S7CI">
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    </dbReference>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="296" mass="32921" checksum="8F5BC4264DA3ED1B" modified="2013-12-11" version="1">MNCSLPLVTPRDSHSLWYTPTSTYSFAPAPTLPYNNNHRSQHPEGGPTLAGQNRDTRPKNAGLSALQQLELDEANVAARKLHIQRFGSTWIRPPGMAKTYQGELDEKAEREEAEAQEMMEDVDLPLDGTFDEGEDAAHGNRDLDADIPNGIDGSDLDGDIQTEADSFVGEEDDLDGDEADLDADIPEGEAETLWDDSDEEDDEDDEEEEISGSEVEEGSEIEEGASYASASHEHSTEPDSISNDGFDAEVSNHQVAFSHDERFPTVFEQGRQGYDWRARARYRRNRADHEMEVESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAP4</accession>
    <name>U4LAP4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Calcipressin-2 acc. no. Q4R4P5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAP4"/>
    <dbReference type="STRING" id="1076935.U4LAP4"/>
    <dbReference type="eggNOG" id="KOG4019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIVCSFH"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="267" mass="28807" checksum="B8EDA3F4F392EE7C" modified="2013-12-11" version="1">MEQSPLAQGNLSPIASPTRSRASSRASHLTLDLSCINNPPPTTPTNTLLITNLNDLSIFSAPHLQSLRDAISLTAAPHSWSPLKSFRRIVCSFSSVDDAIAVRSQLDGTAIMGERIRVYFGEPTPITPVDQHLQAPESKKLFFISPPPSPPHGWESKEEEPPNSVVVAEDLASALAKLNWVTKGDNGDGQESRRGSWMGGRPRSCSSVLLFSPEDGSEEMPAISVDDYTDSGDENSPIEAPRGGAAKYIPEKATIHTARPPVELMEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAY9</accession>
    <name>U4LAY9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAY9"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX16643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="505" mass="55478" checksum="7A383E847B9BA8A2" modified="2013-12-11" version="1">MDVEDREIRLTKKLRLAVGICLIETLVTMQYSVIITAANDIVADKAPTGLVLFAYSIPSILTRIIVPLVRFPDSSNFPIASLFRSSRSGDAIDNSTSLTKEINYPLRLIVCAASSAIGLQLLAHSSNIGVLILGIMLAALSSNLGDMSLQMLCARYPNSSKSAFGGYTAGSGFSASLGAFSYTYATSRMGLKYTNAFSIYGIAPLIALLVYAFLLPEPEGAVATAAEEEQEGIVRLPWKDKLRIIRPMFVPYMLPLATIFFVENSITQGIFPTLLYYVPIKDGSFFLSRFFHGVFHETRDFYPLYLTVNQLSSFAGRFSFWLFRLPGGSTRSTRAYWALVYIETFALILQLANSLSMQTSPLPEQPESSVLYGPMGVISLAGVQGLAAGMVFCNTYWKILQKPLPSAVYDALDDSRARIGLQERRARADSEEEAMGLLTLSDDAPKSEREYSSSEETALREFLLSTIAPPDVVSVAVASIVGMALQKSLCDWQSFHGRELCVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBD2</accession>
    <name>U4LBD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein cps3 acc. no. P41000</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBD2"/>
    <dbReference type="STRING" id="1076935.U4LBD2"/>
    <dbReference type="eggNOG" id="KOG1039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDMIPTI"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="628" mass="67119" checksum="FBF8C2EE020B0BCD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBE2</accession>
    <name>U4LBE2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_11055</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="HF935619">
        <property type="protein sequence ID" value="CCX11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBE2"/>
    <dbReference type="STRING" id="1076935.U4LBE2"/>
    <dbReference type="eggNOG" id="KOG0346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="57"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="249"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="556"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="603" mass="67249" checksum="B4A00807AFC9F77A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBY6</accession>
    <name>U4LBY6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBY6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4609" checksum="1865740C1E7D8BB8" modified="2013-12-11" version="1">MLTIYQALPAVPDTDSETMVHHLGIRFRSGLISSIPYSDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC11</accession>
    <name>U4LC11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein SIP5 acc. no. Q0UJC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC11"/>
    <dbReference type="STRING" id="1076935.U4LC11"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSTSWAE"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="608"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="608" mass="65626" checksum="3A3A81B4BB199DE5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCA4</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">PCON_07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="142" mass="16013" checksum="4231C5D73DFC98EE" modified="2013-12-11" version="1">MRAGPSPPGSMHRVESNWRQSASLEVFHRINWNVRINWNVRGRGGVVSREKLCFRGNSSKLSPRRVAYFRCARRTKRHRRTAFEAVQTRHELGVLSTPQLAATPSSSYSLILQASDITKLISSNSKGSQDYQGSEGCITQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCD0</accession>
    <name>U4LCD0_PYROM</name>
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        <submittedName>
            <fullName evidence="10">Similar to General amino acid permease AGP3 acc. no. P43548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="STRING" id="1076935.U4LCD0"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="68"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="563" mass="61837" checksum="1DBA766D7103A5E5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCQ4</accession>
    <name>U4LCQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Serine/threonine-protein kinase RAD53 acc. no. P22216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_06319</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCQ4"/>
    <dbReference type="STRING" id="1076935.U4LCQ4"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFCGTML"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="239"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="921"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="756"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX29658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114445" checksum="4A49034F88FE77A9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDZ4</accession>
    <name>U4LDZ4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX29752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDZ4"/>
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    <dbReference type="eggNOG" id="KOG2145">
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    </dbReference>
    <dbReference type="OMA" id="CIYDNFG"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
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        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX29752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="439" mass="49469" checksum="B84777479FF4306A" modified="2013-12-11" version="1">MTDTPQPPKIAAEALPHTDVPQNPAPPASTGQNINPWEVSGEVDAAGNVAAIDYEKLLNQFGTRRISAELLERFEKLTGHRPHILLRRGMFFSHRDLEKILDRYEQGKPFFLYTGRGPSSDSMHLGHMIPFTFTKWLQDVFDVPLVIMLTDDEKFLFRPQLTIPDVKKFTRQNAADIIAVGFDMKKTFIFSDFDFMGGAFYENVVKVSRCITTNQAKSAFGFTDADNIGKLHFASIQASTSFATTFPHIFGTAANVKDIPALIPCAIDQDPYFRLCRDVAQRLKYQKPSLIHSQFFPALGGPGSKMSASIDSSAIFMNDTSNQIKKKINKHAFSGGQETAEEQRRLGGNPDVDVPFQYLTFFLEDDEELESIRVAYRKGEMMTGELKAKCISVLQEFVGGFQARRKEVTDKIIDEFMDGKRPLEWKQGKGEKKVVELRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE14</accession>
    <name>U4LE14_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_08526</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE14"/>
    <dbReference type="STRING" id="1076935.U4LE14"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVPCIYL"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX30329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119120" checksum="E4B682086982B614" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEU6</accession>
    <name>U4LEU6_PYROM</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        </location>
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            <end position="50"/>
        </location>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX30072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="286" mass="31999" checksum="059037CAEB04FA3B" modified="2013-12-11" version="1">MSSFQYLGSDPQTSSSRHPADAHLVWEGPPDDTSSVVGTSGSVQSLVSSGYQPPLTDGASRDDSDLVSIESLNQRHRLPTPSEEYDPSAPRIGQTIECLFSFEGCEIQFHNNTTGYSGWRAHVFQQHLTQAQRDDCKPDRIECCNHLSSTLDALLEHIVFHYAMIERFRVDATIIDYLRAQNIIPSCVTEIPPPRHRFQRAPTIQSAGSTSRRSVSSYHGDTYTPRSPEIAYSYRGGRASQDLRGLGYDVHADVLRTSYPQEFNELDEYGESERGSSSRSRSTGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF61</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX10127.1"/>
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    </dbReference>
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        <property type="entry name" value="SAT4-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="331"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="392" mass="44669" checksum="D65B8186F1A800A8" modified="2013-12-11" version="1">MRYPNDIYYDKFQLPIFLTILTVLWVVVGARLWAFRKHHPGWKSFRGISMTLTVGAAIICTLYVGLLIACYFINARILNIRDYTGQDGKERKPSTYTDEEVNTVIHSSVQLFILMFCERILLVAGLWMVKFAFVALFLETREALGKIWRRLLYFTALTILVTFVIGIWSICQDMLRQWFQPSPTQVREKELYVNGMRFTALEPSNEFVLLVSNIVTDLQLVTIGCRTVISLNRPISAASLIVIMVFITISVAISRLVLNAVNMHLAEYSSHGTIPLQLLAEMEVFVASVISCLPGLRVYFRERRLRDARSPQTVPENTVIVMEETGQWMEEGGDRWRGGHNGHNRTWRDSGNDAGVQKGPGFEEVVKGNQVTGKMKKKKKKIEIRSEAKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF98</accession>
    <name>U4LF98_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Methyl-CpG-binding domain protein 4 acc. no. Q9Z2D7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF98"/>
    <dbReference type="STRING" id="1076935.U4LF98"/>
    <dbReference type="eggNOG" id="KOG4161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PAKAYNT"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="334"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX10167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="507" mass="57471" checksum="8A452FE71392F9EB" modified="2013-12-11" version="1">MAPYTTAGVPGLFFKKKIKAVQKRRIPSPKPVKSREMAMNLDASESATIPETRNEEDMEVEQGFNDNEFQAQSVDGPENQVSDLSVNGTETDNHSLQQLQDTSVWNHETDINSDGRKENHSVRPEKLNSFDDEPINTPAKAYNTRANRPPLHPIQTSNLYNPPFLTPPPSAVSQLSSTRKRKRAPYSEELPTRKLVPVVVIETPTKKRRTEYEEFPSLPSRQMAPVVLIATPKKKSDNMYVRETRSSARRRRELEASLVPETPITTKFPPTPPGTTSPLKICDDISNSGPDQPASEILVSPQDIKTNLVLTRPSPKRRKTAKPSAFQLLIATKFLNRTKGSVAGPLLDQFLELYPTLEKLADADQKSVEQFMQPLGWYRVRADRMIKMAKEWVLNPPSLEEGKEILTVLGHGGWKKKLKWEIAHLPGVGAYALDSWRIFCRDEFCGRKEGEEEEEWRRVVPKDKELRAYCRRLWAKEGVSWEEEGDGLMLGDSIIRADDTTHHDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG30</accession>
    <name>U4LG30_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Protein RTC2 acc. no. P38279</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG30"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISQCVYY"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652264" evidence="8">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="332" mass="35938" checksum="602B0E81818C2D02" modified="2013-12-11" version="1">MVGLFASSTLALSSLTTTNAGPDLTVSEALSGIAGSISLVSWIVLLLPQLIENYKNGRADALSLAFIAAWFLGDVANLIGAIWGSLLPTVVAIAIYFCFSDMLLLGQCLYYNSLTSKASADSSPIDTPQITISRPTQDLSTEHDPLITDFERRRSSVASRRSSVALERQRKDSLSSILRDDANSLSPAAREVLSILAVIAAGTVGWALAYYSGAWNVKGDPEGGREMPMGAKVLGYLSAVLYLAARVPQIVKNAREGSCEGLSRLFFLLSLLGNITYGAGILLHSTEREYVMDNLPWLMGSLGTMAEDIIIFIQFRIYSKKDHHHRTVEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG47</accession>
    <name>U4LG47_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG47"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3327" checksum="A5E80A42C0149177" modified="2013-12-11" version="1">MNRDYRTIAIIYAIMICLASCIGICSSPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH03</accession>
    <name>U4LH03_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH03"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="176" mass="20323" checksum="F5A4AA6E2AA31974" modified="2013-12-11" version="1">MSRPSRYLGFWGDISEHINDEARYQEFLGTLNTYGKPHQLGELLDAVYPFIGDNPALFAEFKQRNTVSPLTPDTSPLRSIDNLPIDKCNPVFFAAVKQYFGDLGHKWRYIKFCKTLETHAQGQLDEKMMVDRVKELIGSKQELWDEFLRLWDIEVTPPSQNTVNHPTQQNNPGFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH97</accession>
    <name>U4LH97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Actin patch protein 1 acc. no. P53933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH97"/>
    <dbReference type="STRING" id="1076935.U4LH97"/>
    <dbReference type="eggNOG" id="ENOG502QSDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTPWMNM"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652303" evidence="1">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="492" mass="55022" checksum="778F8007992201AD" modified="2013-12-11" version="1">MLSPLFLLSLIPISLASAVPNIAERELQRRTLADVVNGLANGISVSDITQGILPDFFDNLPRADQIANKFNINNAAYDQAPVEVLNMPGYANWTSNGWNWRMHAWAYKQPMSINNQSIVSQAVLDRAANVFLAKFDINQLQPHEQQNARNLTSAVLAIPQSDVQLDFLLTLQTPQQNLSSWTAQVVWPTRTDARGEVDGFVQLPLVPRGGEQPWIPDGSQTHQITRLDVHTSVSNSGNSSAYLIPPEGVIILSDIDDILRVTKIYNPQEGLLNTFARDFVPWENMPELFADWKGQHPEQPYHFHYLSTTPEQATRAYIDFIYSNYPLGSFDTRPLNFTTVEQTFSVRKLLVEKILQTFPNRRFVLIGDTTNSDVMQEYPAAAKAYKNVMCILLRNVSQTDSTNRFPYDTSGFRGLDQAMYMFFRTPNDLKGLNFGNGDCRNASVRDTVTFGWQNLPGGINTSKGGSTSGAPNRRVGLSGVLVVMGAVGWWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHD1</accession>
    <name>U4LHD1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHD1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="8880" checksum="E5CACDDA4EC07C08" modified="2013-12-11" version="1">MLDVGNVALPATWLGIRKTISFRSPSIENVDADAGKAGPFAPGLTTGMLGSPSLASGTGWHNHVMQSRGKIGLGVDDDDGDDGDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIK4</accession>
    <name>U4LIK4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIK4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651626" evidence="2">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="16429" checksum="BDEF9F70CD599A04" modified="2013-12-11" version="1">MKPTIIMILTSATLAVGNVVHIKPDTSLSAPDAVTTRSTVNPHDFSPDQASGIDYAEILGDSSSSDFAESAEDSSKRFQKYKEAEYNNPHDEYGEQDDDHQNHPRGGGGGGDNRCGGKPKCGLGIFFPGGINSATSVHIPLSAAVAVAAVAGGVVAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIK7</accession>
    <name>U4LIK7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIK7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5814" checksum="A48410FA1F428324" modified="2013-12-11" version="1">MFNTRSYTLYRKNTTLQHRSWMFHAGNNPTDYNGSHYHQPDLQNGIAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ57</accession>
    <name>U4LJ57_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ57"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6903" checksum="536FB4D731167A90" modified="2013-12-11" version="1">MEWMVRCETSGLKWVFVISSGCWIMWETVGSQGDDSWPGHTRIAKLLDSIRSLSTRWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJF5</accession>
    <name>U4LJF5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJF5"/>
    <dbReference type="STRING" id="1076935.U4LJF5"/>
    <dbReference type="eggNOG" id="ENOG502TJBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SVMRIKG"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="3">
        <location>
            <begin position="697"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="760"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="893" mass="98934" checksum="25F8B8317571AA30" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJK3</accession>
    <name>U4LJK3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJK3"/>
    <dbReference type="STRING" id="1076935.U4LJK3"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="36"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="393" mass="42244" checksum="8F4B1170DF6FA8F0" modified="2013-12-11" version="1">MSAFNLQTCARSNILKLVPYRCARDDYKDDGSNILLDANENAFGPSLPAANYDATLHRYPDPHQIELKQQFCDLRNIASPSPVKPTEPIKPENMFLGVGSDECIDALLRMFCIPGKDKILTCPPTYGMYSVSAQVNDVEVVKVNLKPDFSADVDAIAAVLSAPGSEEIKLVYLCSPGNPTGKLIDPEAVATLLNHPTWNGVIVVDEAYIDFAPEGSSVAPWVTAFPNLVVMQTLSKAFGLAAIRLGASFTSPEIATVLNSLKAPYSISSPTSALASAALSTEGLEVQRKKVAAIIAERDRLVAELPKIEGVGKFLGGFASNFLLVEMLNKEGTPCNTVAVKAYESLAETRGVVVRFRGKEHGCTGCLRITVGTPEENSTLLERLAEVVKEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJQ9</accession>
    <name>U4LJQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935728">
        <property type="protein sequence ID" value="CCX32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJQ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="319" mass="36869" checksum="4992F58A78C98449" modified="2013-12-11" version="1">MSSTTSMDNTITTALTAINSASTSLSLSLTQFIDPFAESWQLIGHDTLQNFYQDSISLSHKYSPWTLYNTTAQRHPLYSKLLSELKTLDKVTDTYIGISKNLGKLGKEVYELDKKSKKAAKKMREMLKKVMKEEKKIRKKQEKRDAKTIQKGKAREITGEPGGAVDSMQQPAFPKFDTLFCQRGDCQELLDRITVLLQDPKNECRRYYKVEMIPKTFERYQDDMREKSYYKGWQFPEVLRNARKRLEGVLEEFDGVMKEVSLKNPFEDGRYEVQEQEMAAEEGDEDEGVNGEERGDNGEEDRGIEDEENPFRDGAEVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJV1</accession>
    <name>U4LJV1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to 12-oxophytodienoate reductase 1 acc. no. Q9XG54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935734">
        <property type="protein sequence ID" value="CCX32233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJV1"/>
    <dbReference type="STRING" id="1076935.U4LJV1"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DPFRKIW"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="390" mass="43124" checksum="73CA50E46303BF5F" modified="2013-12-11" version="1">MPAALADTKLFAPLKLGSITLKHRVIMAPLTRVRSPEHIPDENVLEYYKQRASDGGLLISEASHISVMGGNYHGAPGVFSPEHKRAWKKITDAVHAKGGYIYCQLWHIGRAAHPDCLGGRKPLAPSAGKIENGAVFFTAKGPQPYTEAAEMTLEDIKDTIEDYVHAAKLCIEAGFDGVEIHNANGYLLDQFICDNINKRTDNYGGSVENRARLTLEVTDAICAAIGADKVGIRFSPFGFFQDTQTSDIIGHYGYAMQELDKRGLAYIHLIEPRQDLMGSEEAKVARLRELAKARGQSEENLLSIRPFRDIVKNTVLLTNGCFHAENAVPTLEKDEADGIVYGRYFISNPDLPARLANGHELTPYNRDTFYSSGNEGYTDYPEYSETQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK25</accession>
    <name>U4LK25_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK25"/>
    <dbReference type="STRING" id="1076935.U4LK25"/>
    <dbReference type="eggNOG" id="ENOG502RYID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWTEDIT"/>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="807" mass="88001" checksum="6F5F02C56E6B1171" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKL3</accession>
    <name>U4LKL3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKL3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="7094" checksum="4382FCDF0A827F0A" modified="2013-12-11" version="1">MRQKTLYGGFRYAGWRADTSYGLLSSDGTFFLVRRDSLVPNITYFIRIPLGVHEVCNSNVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL04</accession>
    <name>U4LL04_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL04"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10478" checksum="E8EAA24418812EF9" modified="2013-12-11" version="1">MSSFQSSGSVPETIVSTSPAEILQMIAGDGIPECSWMDLFYIGPQDKAIYEELPGVFREPDQQRRPRFCSALTPFTLCSRHFYVTVPFLLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL73</accession>
    <name>U4LL73_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL73"/>
    <dbReference type="STRING" id="1076935.U4LL73"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="201" mass="22216" checksum="0F54ACA81185F693" modified="2013-12-11" version="1">MDSLCRIAGTISSACFCVSAPFAGPFCGQKLAGYWLLLFLPSVIAAQVACLHAATRETPATIASPTPPTPSPYVTSADNTPQAHTAMSTEASSSRPRRSRRQNLFVKELRTLMYAYGDEPDPLPESVQVLDEIVTEYIVDMCHDAARMASQARRNKIKVDDFKFALRHDPRKLGRVEELLVMSKVIADARKQFDDKPEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLD2</accession>
    <name>U4LLD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLD2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="20589" checksum="76CEF8E9115B1813" modified="2013-12-11" version="1">MNPQPVVQSVVYYRYLYFQPVSKCNNSKQPRMQPQTPKMQRLSIEPLQRLPRVDHYLGRISSIPPLLFLQIYEFLSEPEIASSCPLTLTALQQPRQHNLPPLIVPKIRVFTNDSIRKCTEPSAPIFLRHILLNQRSNFLWCFYKRDQFRRGGMRASQSTLPRWWWNRRSLGVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMA5</accession>
    <name>U4LMA5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMA5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="10030" checksum="2033AB1A4F09AA70" modified="2013-12-11" version="1">MPAQLRHFVSGKNSNQPRTPTPKTQTTVNGHRNLIHPTLRISLRSPPEHHRELKITYLECDSPSPVFRLICTQANRRIRSQGDPRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMQ9</accession>
    <name>U4LMQ9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMQ9"/>
    <dbReference type="STRING" id="1076935.U4LMQ9"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000120">
        <property type="entry name" value="Mismatch repair endonuclease PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="218"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="835"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117647" checksum="E82EBA90688BAF81" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN54</accession>
    <name>U4LN54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN54"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5673" checksum="6C29EFF94F0FBAB5" modified="2013-12-11" version="1">MRLDQRVELSEDSYGQYFKVLYVCYFIPRLLSSFAVGVLLDYCSDKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNA9</accession>
    <name>U4LNA9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_09203</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNA9"/>
    <dbReference type="STRING" id="1076935.U4LNA9"/>
    <dbReference type="eggNOG" id="ENOG502QSNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DANTNML"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="15">
        <location>
            <begin position="169"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="627" mass="70755" checksum="8061EB646F06F4FF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP47</accession>
    <name>U4LP47_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP47"/>
    <dbReference type="STRING" id="1076935.U4LP47"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VVTWRGH"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="337" mass="39060" checksum="C62BE83C8019DB27" modified="2013-12-11" version="1">MTAQSSSFPLNQQLRRGAAVRRPQEITCFSYDDQHQYQSDASGLRYYYNPQLDTDLSQGFEEFDQHDDSVDEHLDSLLRAIMEHEKATGKKCATDIMTWRGLITKASAITSFLEENHSYKMANRWKPDRRGAQMSFWGYKFESLATLPKTWHECTREEVDNRPNERVSNKAQFCSIVKTGLGDTKLILGGEVDAVWDVRPSYVELKTSKLPVNERDEVTFERKLQKFWAQSFLLGVGKIVVGFRDDHGTLLSTRDFETQAIPAIAKRSQRRLWDGNQSIDFTAEALRWIKEQIHEGGVWRIKYDPKGNREITITKVEGEKTFLTQEFLEWRETATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPI8</accession>
    <name>U4LPI8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPI8"/>
    <dbReference type="STRING" id="1076935.U4LPI8"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="425"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="744"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="857"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="901" mass="99434" checksum="BD06A65100B952A1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPK9</accession>
    <name>U4LPK9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">PCON_10386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPK9"/>
    <dbReference type="STRING" id="1076935.U4LPK9"/>
    <dbReference type="eggNOG" id="KOG0636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="176"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="397"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="397"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="436"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="577" mass="64309" checksum="84A67377393642D2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQE0</accession>
    <name>U4LQE0_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="409" mass="46400" checksum="AA7AF5A38F84AD39" modified="2013-12-11" version="1">MHTTELESLIDSELDGRALQSKRGLVNLLQKDSFFLKLQNAELANVWRQLSGKITSFFETEDSPTLWRDENDASWRRKGHAELTVQRSSAQLFSPNEVRLPIYKNHTEMVKFDSAVDDNFVSVVNIMTKYISGASPEWGELVDCMLLDIRASKIPNDLRLQSPTQNTSYYWIVKHIDFQQWISSASPTNLWLFAPEKCELIKSCGELPGILGAPIKHDEYSTFRIIITGSSDDKDPGSKTLLFVCALMYQLLSSISDEEKSRCILKTFLNVVSEEYKGPMPIQIARDLQASMGKVTLENFLNKLHGSVTARPFPTNSLWKALKTTLLSSAHLLDHPLLVVAAFTFTGETDCFFKEYQLLLKEARCALHLKVLSILETTHDLGKSTIYDLRGETHIEYDTERQGINNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQG9</accession>
    <name>U4LQG9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936527">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQG9"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27796" checksum="2D65589BDBC9E029" modified="2013-12-11" version="1">MRKALSDLKTNISNQRNSLAAEPEPAMADHPTLTRRPSLARTTVNRALSNLTSITNRRHSLPVQPNPPAVPGYPLVIRGPSRTRAAVDRVVNICRRIRHPLPLCNTHFLLTPPSNDRPYEFRPGLFVVQSNPEIHLTTPKAYTAKLLSVKTPTFHDGSAPAQLVIPVDEPHDDLQRMPVYVGEEAKSPRCDRGSCCLSEGRLAGQTYWKCKFCAKRHHCNMCVEALVKDNPDAEGQCIYFRQFHRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQZ7</accession>
    <name>U4LQZ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protein YTP1 acc. no. P53584</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQZ7"/>
    <dbReference type="STRING" id="1076935.U4LQZ7"/>
    <dbReference type="eggNOG" id="ENOG502QRB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFMGATE"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652580" evidence="3">
        <location>
            <begin position="26"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="160"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="452" mass="50428" checksum="E93E1122F2E825C0" modified="2013-12-11" version="1">MLQRAKMALSIRSVLLLAAGCVVSAHEHHMDAIPPGEAITMEPLDRTLWWHIGLMTLCFGILYPIGMVLGIVKSRYHVPLQLATTLVVITAVILGHAHKGRQFAPNIHGYFANILLWKLGLQILFGVYLKLHLSSGIHARVRPYVVKVHSIFGKAMPVLAWAQMLFGGITALGFCRQDHLGQCLAHFIMGSAFIAYGILLTIMLFVGQAWLKRSGKSQEFWDSLVIAGWGCVNTFTEHRWGTEWNHGDIQHTSMGVVWWCAGLLGLWLSRGKNGEPRRNIIPAMVIFITGWAMSGHVQHLPVSTMIHSVFGYTLMFAALARIVEICFVLKDGPTGEIPNSWQHLTPYLLFASGFIFMSATEEQMALIATAGIDHVSYLIILYSLAFLLYLFVQILLHIFVTSGTNAPIRKLDAPLEEGRQRHEAEQRAREAEEFELEGLISDDEGSGDERKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR58</accession>
    <name>U4LR58_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_03699</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR58"/>
    <dbReference type="STRING" id="1076935.U4LR58"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHFQETI"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="184"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="421" mass="48060" checksum="B5F40CC30B58175D" modified="2013-12-11" version="1">MQPYALYTRQRKKTLFRACVQYGTPESEGRIRISTAPSSGIRNPSCPQSCYITHPYPSPGTVPIHIPTPLSPSFKLFPCPVPYPKSSLSSRRSLRHIPFRNIRRLSLEASLRPISKDHIIKMSVDLERSLSHELESGYDSGIQSVASLQTIYFTPPHLKYINAQLADLEPEAILQWCLITFPNLYQTTAFGLSGLVTVDILSKISPKKPIDLIFLDTLYHFKETLELVDNVRKRYSNVDIHVFKPDGVDTVEEFEAKHGEKLWETNDNFYDYVAKVEPAERAYRELEVKAVLTGRRRSQGGKRGDLDIVEVDEAGLIKINPLANWSFPQVKAYIDEHKVPYNALLDRGYKSVGDWHSTQPVKEGEDERAGRWKGQAKTECGIHNKRSKYAEYLRQLEMQQQEQELTQALEKVQLQQTADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRB7</accession>
    <name>U4LRB7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRB7"/>
    <dbReference type="STRING" id="1076935.U4LRB7"/>
    <dbReference type="eggNOG" id="ENOG502S411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DNDAYGH"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="17772" checksum="E9FDABDE039605E9" modified="2013-12-11" version="1">MSLKQRTRSHYRYFELHRLRWSDNDQYGHVNNSIYAFLIDSIVNSYLISSCSLRPTDSSSPHIGLVVASKCQYFASLEFPEEVELGLAVRKMGRSSVEYEVGFFRKGRDEVSAVGGFTHVFVEREGRRPVKELREELKEGLGKVLVPLGEEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRJ3</accession>
    <name>U4LRJ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRJ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="7086" checksum="5633EA1BCF580E4F" modified="2013-12-11" version="1">MGCKFPRGGGGMFVRGLLGIECRVKRYSCLNRCEYHSPSCKLFRDTDSRKIDIYPSNPQLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRN4</accession>
    <name>U4LRN4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Engulfment and cell motility protein 1 acc. no. Q92556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_04334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
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        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
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        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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    </dbReference>
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        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="240"/>
            <end position="420"/>
        </location>
    </feature>
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        <location>
            <begin position="249"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="687" mass="78215" checksum="A86F2E316FE8E429" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS42</accession>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein kinase regulator activity"/>
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        <property type="entry name" value="CBS-domain"/>
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        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
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            <end position="293"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="36767" checksum="5A10C052B37C27B3" modified="2013-12-11" version="1" fragment="single">MSDLESTPSRPPARLPSPVRPSSYLRPRRSPSPPPAAEKPEWKQKEPLTQMDREQLEALHAIREFLKIRTSYDVLPVSFRLIILDTGLLVKKSLLILLQNGIVSAPLWNSKTSAFAGLLTSTDFINVIQYYWQFPDKLNQIDGFRLDSLREIEQAIGATQIETVSVHPMSPLYDACTQMLSSRARRIPLIDHDDETNQEMVVSVLTQFRILKFIAFNVRECRQLRKPLGELGIVKEKDIVTAMMNTPVMNVIHMLVKADISSVPIVDENGILLNLYESVDILTLIKNGSYQDLALTVGEALLKRPDVSLPIRPPYYPPTTPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT90</accession>
    <name>U4LT90_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to PI-PLC X domain-containing protein At5g67130 acc. no. Q93XX5</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_04615</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LT90"/>
    <dbReference type="eggNOG" id="ENOG502QVX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNNYVEF"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651888" evidence="2">
        <location>
            <begin position="29"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="436" mass="48189" checksum="25607CD697F2A561" modified="2013-12-11" version="1">MLKPRLQLRSAAIFLSLSLFSATTSGWAFPDPQGVSPTTTTSFGGAAISGPSGSGSGFDSSSFPIATGTSTTISEVLLKGTNDLDPPKATNARNETITGTETDVPTQTDNVPAPTNTQPCNQYVEFCNRSWGNITFVAAHNSPFVRSNNAASNQRLDVIQQLNDGVRMLQGQTHKVNNTLYYCHTTCDLLNAGTVEDYLKKVVDWMHKNPYEIITFIIGNGDYLKAEEFRAPLENSGLSKLAYVPDNRTIAYHQWPTLSELILKGKRAIVFMDYEADENKIPYLLDEFTYMWETPFSQTDQNFPCTIDRPPDKKDWERKLYMANHNLNVEFKVYGTPALIPNTIEINQTNGVEGFGSLGLQANNCHTMWGRYPNFLLVDFYDSGNGSVFEVAAKANNVTYPGGCCGKVKSLATAAFVDPTWLVAEFLVFLTFFVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTG4</accession>
    <name>U4LTG4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTG4"/>
    <dbReference type="OrthoDB" id="10363069at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="509" mass="56343" checksum="A91CB73173AF7FD0" modified="2013-12-11" version="1">MARYFPRTPGGLPAPLSDEEAQSGLALEAEMRRLVAEQIAASVSRGASPRGAYKTSATQSKPELWQATASKLSTAPVIDEASLLGGIHSNPSPRGAPPINTSFLQDQNRRQSNASSEMSRTSTRSTNEEKKRKILENVFGIYPAENKLPPGRSTADELKANIAKAFQFGRKSSTATLEEKHTISAMGILASDNVYAAMELPTFMTSPVVVHESTRRHSDIIDASSRGRKTRPTSPTRQRKARSQSRKASRVKTLALKPKLSNESLYANEPLPAIPKLQINNEKPEARSPSPQFTIDIAEWAESTYIFPKNPSQETLAIEKFPKPPNPPKLPFPEASETPRTPRCISHVSSQSTMGYSNRDSMVSYDTFRGGTTVSAISEYDDTPSVSDTDESFFERYDEWSRGDGASDYRASYPFDVEDYIYDPQALGDEVSNEKQLKPTPTTKRHASITGATGLNVQFTTYFAEKQKIELKVRDLASRMEERDHERMASPRKVPGKLSLFPTVYPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTP7</accession>
    <name>U4LTP7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_14030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTP7"/>
    <dbReference type="OrthoDB" id="10434060at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="614" mass="68487" checksum="E6B05298908C7F92" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVB2</accession>
    <name>U4LVB2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LVB2"/>
    <dbReference type="eggNOG" id="ENOG502RY9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1447"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1472" mass="162563" checksum="D43FAEBBE98FEDFA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVN3</accession>
    <name>U4LVN3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized hydrolase C9G1.08c acc. no. O14304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVN3"/>
    <dbReference type="STRING" id="1076935.U4LVN3"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VMQFFAR"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="249" mass="26890" checksum="958B7793C40E2861" modified="2013-12-11" version="1">MTEPRVPEASDFPKDAVVEIVLPKDKSKPVSNILILLHGLGDSHAPFAALGAQFNFPETACLAVRAPLVLPFNPNGYHWGDDLIFDTSTGGLDMMGSTFNASHKLMKEIIDDVLVGKCGWKRRAIFLFGFGQGGVVALDVATQVPAEGPDAEFGGVVSLGGPLHHSAPSPAKKIKTPILVMGAEKNTAITPEAAQRLKNVFEFVEIVNWKGRKEDGMMKNAEEAMPMMRFMARRLRSRAGIPKGAIELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW01</accession>
    <name>U4LW01_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_14050</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW01"/>
    <dbReference type="STRING" id="1076935.U4LW01"/>
    <dbReference type="eggNOG" id="KOG0973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RGSWDGD"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001073">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="29"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="700"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="995" mass="107225" checksum="EEC7AE4B1A537B2C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW81</accession>
    <name>U4LW81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to TRAF-type zinc finger domain-containing protein 1 acc. no. Q58D05</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW81"/>
    <dbReference type="STRING" id="1076935.U4LW81"/>
    <dbReference type="eggNOG" id="KOG1816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THLKHHE"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7590" evidence="4">
        <location>
            <begin position="229"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="TRAFD1/XAF1 zinc finger" evidence="3">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="2">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="708" mass="79529" checksum="4F9F0CAD0B2993B9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWE9</accession>
    <name>U4LWE9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LWE9"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <location>
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            <end position="949"/>
        </location>
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        <location>
            <begin position="1137"/>
            <end position="1258"/>
        </location>
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        <location>
            <begin position="253"/>
            <end position="419"/>
        </location>
    </feature>
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        <location>
            <begin position="1094"/>
            <end position="1131"/>
        </location>
    </feature>
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        <location>
            <begin position="1276"/>
            <end position="1385"/>
        </location>
    </feature>
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        <location>
            <begin position="277"/>
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        </location>
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            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
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            <begin position="1109"/>
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        </location>
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        </location>
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            <end position="1360"/>
        </location>
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            <end position="1373"/>
        </location>
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            <position position="1188"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1385" mass="151834" checksum="7D360ABB8E8E0B3E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX64</accession>
    <name>U4LX64_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_03238</name>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="895"/>
        </location>
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        <location>
            <begin position="66"/>
            <end position="424"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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            <end position="401"/>
        </location>
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        <location>
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            <end position="451"/>
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    </feature>
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        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="948" mass="104854" checksum="D70FC1A98FD788BF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTU4</accession>
    <name>U4KTU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTU4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="15591" checksum="D2A87492A1DECBBA" modified="2013-12-11" version="1">MHRDPLVSPLHHNRQSATNSAHHAQNHQSRRPSMILVLSKPPSKPAKTSLPPTNIVNVNTDAELTNKSGTTSSLTVVCKLPALPRPPKSVWDCHKRRIYKWIGQFAETKLAIEGNFESFGFAGARKTNRKKHDGTKSPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU85</accession>
    <name>U4KU85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU85"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="97" mass="11273" checksum="07F81E6A50C96BB0" modified="2013-12-11" version="1">MDLHFDQRSRCRRTRNCHGQIPGLDRGKWSQAGNRRGPDCSYPELNGLVVLMLLLPLPLLPILLLSLLRRSLRLLLSLPLRLCLRPFRKLLLLRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV69</accession>
    <name>U4KV69_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV69"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="35001" checksum="BFB595FD6A5128DB" modified="2013-12-11" version="1">MLEAILPYDAAQTDEPNASVSLEAIPPKDTLKACGLENIGSSSPAFLERLLSLCRHQKELDRYFRQIIKDQGKGGERNVNSKTSLEHLAKLTHCDHDLQIQSKLTWIRAERDILFPDYFRTETEDLWGNYLKAIEVEVEARTAMLSKCQTLGAASKLAIQEHQKAKKSREEYYQRIRYVVQRTRFELATNPHRYHKSFWSLVVAKVGELDAASECLRKDTVTVQSVAENMAGSTPYVGVSSPSDPWAPVAVRKGEFIEEAEMKKKMKEEEIERQRIEFEGSKRQRLGEWVMSVDPEQDNHEQEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV73</accession>
    <name>U4KV73_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to RNA exonuclease 3 acc. no. Q4WYA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV73"/>
    <dbReference type="STRING" id="1076935.U4KV73"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="407"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="581" mass="66118" checksum="73EA6A5B0A8807EC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVB9</accession>
    <name>U4KVB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Zinc finger with UFM1-specific peptidase domain protein acc. no. Q3SWY8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVB9"/>
    <dbReference type="STRING" id="1076935.U4KVB9"/>
    <dbReference type="eggNOG" id="KOG4696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="286"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="514" mass="58016" checksum="E8F527E86A71CC72" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX68</accession>
    <name>U4KX68_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935286">
        <property type="protein sequence ID" value="CCX06371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX68"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6590" checksum="716BBB9D6C41FDBE" modified="2013-12-11" version="1">MQKAVELDVLTKGEAVIAVQGWREDLDTPTLFASCLRYDGYNMYIVTERPAHYLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXF8</accession>
    <name>U4KXF8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXF8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5304" checksum="9476F2D79852A5D9" modified="2013-12-11" version="1">MLLDLLKLGTWKLLWITEDAGIASFPVNLRIISPGRVEWVVLRIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXL0</accession>
    <name>U4KXL0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_06133</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KXL0"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEMHHQI"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000337">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1565"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1592"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1620"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="1"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="20">
        <location>
            <begin position="1788"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1846" mass="204895" checksum="B50055A59D1A6E4D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXM6</accession>
    <name>U4KXM6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to SET domain-containing protein 5 acc. no. O74467</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXM6"/>
    <dbReference type="STRING" id="1076935.U4KXM6"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGYGCFA"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF2">
        <property type="entry name" value="SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="336" mass="37565" checksum="9393F5D679CE7AB9" modified="2013-12-11" version="1">MDDRESNSAPILYQQAAIPGKGIGMLATSPIASGSLIIAETPLFIVPSNIRDCAVMATPALKSYVLTAVSRLTKPQQSAFLSLHNAQVRSTSELPPFLSIISTNAFGLGIDATKSGVFETCSRFNHSCVPNANFVWNEGGQKLEVRAVEDIQEGEEILLSYLGSKLAMADRLERQQSLRLRYGFQCQCAACGLDAPEAAADNLLRAEAKRLDELIGDGVLIATNPARALKYCRDLMNVRKRLKQTPEIPRVYYDAFQVCVAHGDLARAKVFMRLHNDMKERIEGDWAVDAEKRELVERPERHRLYRQVSRRWNTNVQHAREEGSEGFVEWLWMRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXS7</accession>
    <name>U4KXS7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Yorkie homolog acc. no. Q2EJA0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXS7"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21807" checksum="9E26082FE48EB9CD" modified="2013-12-11" version="1">MVMSCEQPGLKMFLLLHPNQRHHAPRTPLPPLALLLPHSSQGNAVSIAPEAVTDRTSALQFAITISLSIIRDLVYTPFTTHSHLNIRPASRAKPISGSWEKIPLEIRRAFFVNHNAQETTWEDPRGGRNASSYPMRVVEGSKIPDVENKVPLPLGWEQMWYFYERFVDWENDALIWNAMFEHTRRLWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXV7</accession>
    <name>U4KXV7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_05947</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935286">
        <property type="protein sequence ID" value="CCX06360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXV7"/>
    <dbReference type="STRING" id="1076935.U4KXV7"/>
    <dbReference type="eggNOG" id="KOG1733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAAWNQV"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX06360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10767" checksum="46356A96271FF4D2" modified="2013-12-11" version="1">MDGVNNMFGLGGNQTKEEKKQIIIQTIQQQQNIENARVLIDKINTNCFEKCVPKPGSSFTSGESTCMTHCMQKYMTAWNTVSSAYIQRIKSDPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY59</accession>
    <name>U4KY59_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935207">
        <property type="protein sequence ID" value="CCX04519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY59"/>
    <dbReference type="STRING" id="1076935.U4KY59"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMGIRNM"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="413" mass="47297" checksum="DD27194DFC62EB25" modified="2013-12-11" version="1">MSFLNSSPLVALPLLGYCLFAVFIVSIFLYRSTTRRRQTPKSRTPPPEKAGSVSSFKRSDRIPGVWPPSDFVTPLPPPYPNWSLSTPPLPYRPFRHGPKYFITMGLRRLSFSDWIELDSDYLSYHSQKASRIISRGKKCCDTLPSALPHAYELLEELCRYLPARYPSLYRKTDRGMDNIVTGESFDIMERPLKEDPMQMAARWVQDDLAIMVEGGDGQYYLQAGATLLTGFWRLGDKMGMGLDEIHRSGDVPGFESKLRKGMENFFGRLKVEECMGRSNYFIQVDGELPWSPSIGSEDGQPGEFGWFTAEGEKPIEQIYFRSERQSLRRLPKTGGVVFTIRTYFVPVTEIVKEPYVPGRLASAIRSWDDDVAKYKGRERYEKVLLAYLDKEHQKQVEAGLPLEKEEEVVSYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ27</accession>
    <name>U4KZ27_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized acyltransferase vps66 acc. no. Q9US27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4KZ27"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WFRFLWD"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="319" mass="36033" checksum="931538DA54269BDB" modified="2013-12-11" version="1">MEKFSSFRDRGTQIAPFLPIHGPRTNWEKTYGFIMFLLRLPFFISVVGSYLFVIHWLPVGSLVRKAWLWSILGVCGVWWVDLQVEGVRRGTLARQAKAKLPGPGSIIVSSYTSPLDAIYLAAIFDPIFTTSYPTTKLVERVSLPVFLWRYFTPPCLRPAEPSDLISIPDLLKKKPNRTILLFPEATPTNGRGILRFTPALSTAPPKTKIFPISLKYSPADITTPVPNAYMKFLWSLLSRPTHCIRVRIAETIFNNENTARTKSGEYDSSSDTMVEEQGGICERGSEALARIGRIKRLNLGVQEKIGFVQAWQRRNRVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ78</accession>
    <name>U4KZ78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ78"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="97" mass="11129" checksum="3878D550A965109D" modified="2013-12-11" version="1">MWIVRFANIYHAIKNPRNPLLVIRQIHVWGSLELNFALVAFCMPTYRAVLQKKWFKGKEQKKKSTITTIGGGDANKRERSRETFETEMCLETTGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZA9</accession>
    <name>U4KZA9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Molybdate transporter 1 acc. no. Q9SL95</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZA9"/>
    <dbReference type="STRING" id="1076935.U4KZA9"/>
    <dbReference type="eggNOG" id="ENOG502QRGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSMPVCH"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="54769" checksum="9C6E9056EB836940" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZH8</accession>
    <name>U4KZH8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZH8"/>
    <dbReference type="STRING" id="1076935.U4KZH8"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="435" mass="49298" checksum="60ED862314A72677" modified="2013-12-11" version="1">MPPPTTLVVDNGSYTIKAGFGSSSPSYDDVYLIPNCIARTRDRRSLVGTQLETARDFGGMAFRRPVEKGYLVNWEAEKEIWDRAFLETDSPVHADPHETRFVLTEAPNAPLSLQNNCDQMVFEEYEFAEYYRCVAPSVIPWAPTLFPPAPHPAEAALVVDTGFSHTHIYPTLFGQPWNLGVRRIDIGGKFLTNYLKELVSMRTWNMMEEPYLISQVKEAVCFVSTDFSADLEKCKRLRTVDNPLVRDYVLPDYNTYKAGFVRPHGKRGDDEQVMVLANERFTVPELLFNPADVGVKQAGVAECVIQSLEMVPERYRPLLLANIVLTGGNAAIPGFQERFEKELRPMAPVEATVRAMVPEDPVKYTWLGAAHMANDESFIKKRTVTRKEYMEHGLVWAQKTMAGEDVRGGGETIKESSLEKERRENRSHKKRRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L204</accession>
    <name>U4L204_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L204"/>
    <dbReference type="STRING" id="1076935.U4L204"/>
    <dbReference type="eggNOG" id="ENOG502SCMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FENKWEN"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="6">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX10165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="132" mass="15205" checksum="8E6EA0391A693673" modified="2013-12-11" version="1">MFALRRILSGVPRLTRSLHHSLPIPPPPAKTAEVPDVPTFLTKIGRDCQSHAAKIESWEHLFSATSAQLKTLGIEPARTRRYIIRWRETYRLNDGKVQLTEQKRGRKIDGGERRRKEVRAKKMQEARKAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L272</accession>
    <name>U4L272_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935446">
        <property type="protein sequence ID" value="CCX09240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L272"/>
    <dbReference type="OrthoDB" id="10335800at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11836" checksum="BAB45C0A71C4E76B" modified="2013-12-11" version="1">MPPLSPVPEDDLPPPHGSVYTYPTPASPAHSRPPPPDMMIYDGPGSKESILASEYAPGRLHEIGGEYYGPRLRGLDTEASSLSDDIEERREYTTWHWPWWFCIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L363</accession>
    <name>U4L363_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L363"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="69" mass="7605" checksum="0D660DC96B63A9C6" modified="2013-12-11" version="1">MAKFQQVCLPLWRFPVRRGSTCSSSPRSAEPRSILAGVLFTGVGCRYLINSVISVSTFIESDELILSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L376</accession>
    <name>U4L376_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L376"/>
    <dbReference type="OrthoDB" id="5271480at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="173" mass="20048" checksum="2FA378270152EAA2" modified="2013-12-11" version="1">MTVKAATAPRCIGLPTTHHDIPNRMANTRQRDIYEHLRTFPWDVSCLTYLRCRHEIFPDVFSGKSTTTKLVEYLVELRFLANALKGWSEVSLGRSPHHLAPLDKRFITYSIANAYHELPEVFKELMMVKDRTYSSSVKKYCDEVYQSLQEIYNSSDVKALCESVKHCPPPMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5L1</accession>
    <name>U4L5L1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935699">
        <property type="protein sequence ID" value="CCX12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5L1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="44" mass="5013" checksum="3DCC11A1B488BC01" modified="2013-12-11" version="1">MKSGYKGFISEESEERRTEEGILYHTVGRGSETYCKKGLIPELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L632</accession>
    <name>U4L632_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935648">
        <property type="protein sequence ID" value="CCX11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L632"/>
    <dbReference type="STRING" id="1076935.U4L632"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="182" mass="20601" checksum="8D3DDF016BDD8502" modified="2013-12-11" version="1">MPIYSFYIFDRHCECIYVKQWLERERNSLRPTTSSGASIINSPLSGAPDKRISAGTIADQSLRTAPGRLSVQDDAKLVFGVVFSLRNMVRKLSGPEDNFVSYRTGSYKLHYYETATNLKFVMLTDVKMSNLRVVLHQIYVNLYVEYVTKNPLSPVEHPGGEGVAVELFELGLDRFVQTIQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6C0</accession>
    <name>U4L6C0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6C0"/>
    <dbReference type="STRING" id="1076935.U4L6C0"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQAHIKF"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX12020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="221" mass="25373" checksum="71AC23C8589AD671" modified="2013-12-11" version="1">MSADDRKIAERMLMTELKELDKENWVNVEARDGNLFLWDVALIVLNPTSLYHGAYLKAELKIPKNYPMSPPEFKFLRPLFHPNIYKDGRLCISILHSPGDDEMSGELASERWSAAQRIFTVLISILSLLDDAEVSSAANVDASVMLRKDPENYKRIVKENVEASKRDIPEDFQMPTEIESKPPPKEEIDDDFWCDDHESDWDSNSDGDMEFEDENDESGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L758</accession>
    <name>U4L758_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935416">
        <property type="protein sequence ID" value="CCX08472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L758"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4624" checksum="29EB261FE9814BC7" modified="2013-12-11" version="1">MRERALPRVCSSKLTRCVEASASSWLDLLQINRFMTASAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7Z8</accession>
    <name>U4L7Z8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935828">
        <property type="protein sequence ID" value="CCX13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7Z8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="10109" checksum="24B502B8894A5A7B" modified="2013-12-11" version="1">MSITTATETAATEYPRLPTIRSRVTDFPQCTFPKYVVAVLTGLTNGTIPTAPPGRGRAHMDFAELQRAVESGKVGERSTCEEVMRHVTWVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L896</accession>
    <name>U4L896_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to NADP-dependent alcohol dehydrogenase 7 acc. no. P25377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935776">
        <property type="protein sequence ID" value="CCX13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L896"/>
    <dbReference type="STRING" id="1076935.U4L896"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EAIFPMV"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="215"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="379" mass="41160" checksum="49CFA5F02AA7690E" modified="2013-12-11" version="1">MSVPEQFTGYAAFDAENWADLRLHKFTPKPFDAYDIDIKVDYCGICGSDLHVLRSGWSPTIYPVVPGHEVTGKVVRVGPKVTSIKAGDYVGVGAQAWSCGGCDACAGEEVGEKHSSWGPEGEHGHGGKGGLKGGKENYCKEVVETYNWRYKDGSLAYGGYADYVRIHENFVYPIPEGIAPEIAAPMLCAGVTMYSPLARSGLKPGAKVGIVGLGGLGHFGVLFAKQVFNFDVTVISHSARKKEDALKMGASDFWVTSEENWTEKRTRTLDMIISTNFSTDMPLKHYLSLLKIGGTLVVCGIPEGKLPALEWADIATSNLAIRGSNVGSKVEVEEMLKAVAEKDVKSWVNIMPMSDVKTAIQKMENGEASYRFVLKADFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L977</accession>
    <name>U4L977_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein SERAC1 acc. no. Q5SNQ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L977"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="655" mass="73778" checksum="44222D53F15E8AE8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9D7</accession>
    <name>U4L9D7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936243">
        <property type="protein sequence ID" value="CCX15607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9D7"/>
    <dbReference type="STRING" id="1076935.U4L9D7"/>
    <dbReference type="eggNOG" id="ENOG502QWMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQLRWYC"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42498" checksum="DA57429DDB554477" modified="2013-12-11" version="1">MRQIYRNSFATIVAACGKNVHEGFLRQNRPQKVPDAKVPFICPDGTVGSVWIAAEFDTTTGDATRTYYDELEPMNFRGWCLQERLLSPRCLIYASHTLQLWCQHETVNVGQALCEPSNGLRLPSSVWLSEEHGQSVSPSDGETSRQAWLNVIFDYTLRKLSISGDKLVAIAAVAEQFNHVWNSQYLAGLWQHTLLLDLLWYNTGLFELNPRPGIYRAPSWSWASIDDHVVAQSFEDRFEPGAYDLAECDILGCKVTPASADVPFGQVSSGTLILEGHLKEATLQYTKSDQKSGNTLVQLDMDGVSEVVSVGWARMDALEEKSNIWIIPMLWDKGGEFMEGLIVTAAGEGYFRRVGHFTNHYGSKDITWVSSAPKQIITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9V8</accession>
    <name>U4L9V8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_06556</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9V8"/>
    <dbReference type="STRING" id="1076935.U4L9V8"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHMTALF"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
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        </source>
    </evidence>
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        </source>
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    <sequence length="1062" mass="119278" checksum="59CA58A62069E878" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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            <dbReference type="EMBL" id="CCX16172.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAD3</accession>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="10041" checksum="9457D8F807A716C1" modified="2013-12-11" version="1">MHTAIPTPMYPTICPFYLNDFTLEYLLNNKIFDYIEYNLSYNPWLHQPDQQASFHHPNPQPYHLECHIPDTNVNIQPSLHITICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAG5</accession>
    <name>U4LAG5_PYROM</name>
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        <submittedName>
            <fullName evidence="10">Similar to High-affinity glucose transporter acc. no. P49374</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">PCON_10432</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
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    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX10838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="503" mass="55472" checksum="0D98F0B6E02BECA2" modified="2013-12-11" version="1">MALPPKWYQFLVGLFASIGSFNYGYDLGIIAQVVASDSFSSKFAPNPDETGLVVSLFTAGAFCGAFMAGYLGDMVGRRATIAAASAIFILGGALQAGGQNIGYLQAGRFVAGIGVGTLCMIVPLYQAELAHPTIRGRITALQQFMLGVGALCASWIGYGCYVGFAPTDSRQWRVPLGLQCIPAGILGLLIFLFPESPRWLIDNNKVAEGLQVLADLHAHGNTEDPWVRVEFEQIQESLTFEHDHAAKSWGELVKNKSNFRRIFLCVALQGSVQMTGVSAIQYYSPTIFAQIGLSTEQTLKYQAINSIIALIAQFLCMLFIDRLGRRWPLISSNIFNGICFLVGMILLKQFPPGSNNPRSAQIGFIATTWIYNFSFSAACGPLSWIIPAEVFNTTTRTRGVSLATMISFAMNTMIGQVTPIAMDRVGWRYYILFVVCNFTNAIFFWALLPETSKVPLEAMDRLWENAPWFVPTMRRKDYLAELEREAEEVAEKQQTVTTATHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAJ4</accession>
    <name>U4LAJ4_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07179.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10163" checksum="8BA63B6295C17356" modified="2013-12-11" version="1">MGSFDVRGNDYAPIHLDPFAAGAAGAPQWPEILSLPGKVGGMAPSGAIPIDLELFNTCTPGPSVIWEQHYQSLAPTPSHSGKLGCRRWCCTNTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAK1</accession>
    <name>U4LAK1_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936282">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6316" checksum="D2DA8B13E40053A2" modified="2013-12-11" version="1">MMIRDPGDASSEDALTCKFNFGPTTTSRSMTSVVVINLVVKYSYRAIRVFMVRYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAW4</accession>
    <name>U4LAW4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX16271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LAW4"/>
    <dbReference type="eggNOG" id="KOG0012">
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    </dbReference>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX16271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="168" mass="19546" checksum="CA4C940C1778EDC2" modified="2013-12-11" version="1">MFTTSRPRDKFYILFLISFIPTILFFDSVALYPEHLIPTPLQSLQIFYHSTFHDPLLINRPPWFHFFSLVELFYQFPAAVYIMYLLKKRSYKAAPHTLVWATVAAGTTATCVYEFAVSDEMDNGMKWALGGMYGCYGLIFTVMAGDMFCRISRTLRECARVEDDRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBL6</accession>
    <name>U4LBL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936658">
        <property type="protein sequence ID" value="CCX17474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBL6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX17474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="5086" checksum="CBC4A0351B3FD100" modified="2013-12-11" version="1">MDNLISFPVIIRLFSQATSSNEFARKIAHGVYFSVDTGTLHNHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC07</accession>
    <name>U4LC07_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC07"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6529" checksum="30C988D4E7CBFA67" modified="2013-12-11" version="1">MSQDLYRLYVLSEIDFASDAASEQKRTEDNPFRVLVSVTKYLKDSWPAGLVGLWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCE0</accession>
    <name>U4LCE0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized transporter C5D6.04 acc. no. O14197</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX07987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCE0"/>
    <dbReference type="STRING" id="1076935.U4LCE0"/>
    <dbReference type="eggNOG" id="KOG2722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFVVQTF"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="531" mass="58078" checksum="8CC62F10407E6DBC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCJ5</accession>
    <name>U4LCJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCJ5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="2976" checksum="BC469D2A965C1B37" modified="2013-12-11" version="1">MVHFITSLVVMPRCLRIREAHCLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDD1</accession>
    <name>U4LDD1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_08203</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="HF935425">
        <property type="protein sequence ID" value="CCX08610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LDD1"/>
    <dbReference type="eggNOG" id="KOG0560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGSYTQV"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CysI"/>
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    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
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    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
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        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
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        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
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        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
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        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
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        <property type="entry name" value="THDP-binding"/>
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        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
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        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FLAVODOXIN"/>
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        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
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        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="776"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCX08610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1514" mass="165798" checksum="96267C1135CF8545" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDM2</accession>
    <name>U4LDM2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08503</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LDM2"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHAMARY"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="305"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="511"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1108"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1348"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1423"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1534"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
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            <dbReference type="Google" id="ProtNLM"/>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX30989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFV5"/>
    <dbReference type="STRING" id="1076935.U4LFV5"/>
    <dbReference type="eggNOG" id="ENOG502SH5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="59"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="255" mass="29472" checksum="F078EA9F468F52E3" modified="2013-12-11" version="1">MEIIVGSQSSVSWSKWYTEDPNERESVKAYADLAAAEQQRWKTKGRRKVLDGMSTRLSYCQKLADNYKFIVDAVKSVHSQFVGAAWGTLGIFVQVLIQKNAKEEKFDSSLQSIVKSLPLLSAYEELYSTRRMRECMVNLYVKIMEFFQETYLYFKRPSWKRVVSAIIEPAEFKLTLLVDEIGNLSKEIAIQTDLKAVTQLFVDSNYDSALNFSTYKTVTTIPRDTSEVQYSTQLQSRLTSETTPQMLWLMRDNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG78</accession>
    <name>U4LG78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG78"/>
    <dbReference type="STRING" id="1076935.U4LG78"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652267" evidence="1">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="13202" checksum="ADCC6D0C2C1582B7" modified="2013-12-11" version="1">MQFTLFTTLILATFTLGAPLFDEPTLDTNVHPIEHPKGIAARIFETQSKPVEKCPIPYIKGIRRPIADDKDCTRYWICDIEGPIQFTCKQYLHFSPKQGFCTIPSKAGCKLLVAMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGT1</accession>
    <name>U4LGT1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGT1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11362" checksum="99582B244F8BC402" modified="2013-12-11" version="1">MPVRSSRATEPSAPARRGLDDAAVGAQPKRTISPERQQERSRSPPSDRPDHLYNPDVFKNQRCLEATEFLVHYYAQRPQPITVCDPSGDFHVPTEEFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHK9</accession>
    <name>U4LHK9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHK9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42509" checksum="5CAFD80214A2E37C" modified="2013-12-11" version="1">MDPEEQLPWFHDPEYTEGMVVNLLRSKDDARTTEYVRYRDWILHKGLESPDDILRWRRYTVAIEDAWAESEERNEHLNAGIEDLEHDAAVLSNQNNTLEQDLETARAEIKSIQSENCVLKTRVSDAEKAVVRMALSTSTKGPGAPHCFTIDTQILPTFHGERSGEAVKNFLNLLVRYFVVRCHEINWLGQADARSETPTDDSATVTSQSMALRKDGWARYALCQLRGDAIMWASVKFPPELPEPSWEEFCASLREEYVPVTLLNEQWRLLSISPNGDVAAFNDEFMRYRYQLDPLASMPVEQLIDVYADKLRPKISAHADAVTYRSLCRNIDRDFSLEALLAYVKDMDIARTPHKNKKYAEGFPSPGRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHR9</accession>
    <name>U4LHR9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_02804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHR9"/>
    <dbReference type="STRING" id="1076935.U4LHR9"/>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTQRYGT"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="446" mass="47326" checksum="9CDCB9162D5E1877" modified="2013-12-11" version="1">MSTPTEIARTAALASRTLKAVSGDDRSAALTAVHDALAAAKDEILAANQKDMEAAQALVDAGKMKQSLAKRLLLSDSKWDGMLEGILDVRNLEDPVGKVTMATKLDDGLDLYRLTCPIGVLLVIFEARPEVIANITALALKSGNAAILKGGKESTASFAAIANVVSRALATTKIPSGAIQLVQTREDVSALLDQDQYIDLVIPRGGNDLVRYIKENTKIPVMGHADGLCAIYVHPDADAAKAVKVVVDAKTDYPAACNACETLLVHQDAATTLLPKIASALLEAGVSLRCDSVSKAALQGSDLDSAKKLILQDSTEEDYNTEFLELTVAVKVVSGLDEAVEHINQHGSGHTDAILTESKETAESFMNRVDSAGVFWNASTRFADGFRYGFGTEVGISTNKIHARGPVGLEGLTIHKYQLRGNGQGASDYGAGKKAYLHTKIEDINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHV2</accession>
    <name>U4LHV2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_10852</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHV2"/>
    <dbReference type="STRING" id="1076935.U4LHV2"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFERVDM"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="240"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="311"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="405"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="601" mass="66528" checksum="1955517D5BFB1C26" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIF4</accession>
    <name>U4LIF4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIF4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="7888" checksum="A9CB1B6DD7F7E00A" modified="2013-12-11" version="1">MKQVSPEAAGGDEEVWLVGDNSVGITLIPFDSFNKICRVCVGVRKVRDLEEQPSSYCISKKKSRENQQSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIZ7</accession>
    <name>U4LIZ7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_12349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIZ7"/>
    <dbReference type="STRING" id="1076935.U4LIZ7"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="304"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="49469" checksum="517E5DE24BCB31E1" modified="2013-12-11" version="1">MWKPSKALMDTITHYSTFPATGVSLRQMVQFGQNPSQGTLFRGAQFLSEELPIRLAHRVKELNQLPDGLNEMPSIQKVANWYAQSFEEITQLAKPKLSREIKDRLINGFRGGNGNQLPAAIPNPDIEPGKYRSSPWQNGNGNGNGSNGNGKKAVRRYYATVDEGAQWPPEIVDYNKRFTKLLQTIKHRHDPVVTTMAMGINEYKRQKQRMQIDNSIQSFLDRFYMSRIGIRMLIGQHVALNSMPENDDEYVGIICTRTNVKDLAQEAIENARFVCEDYYGLFDAPKVQLVCRPDLHFMYVPGHLSHMLFETLKNSLRAVVETHGSDSEEFPPIKVIVADGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVESEPSIEPDFNKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJA7</accession>
    <name>U4LJA7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935722">
        <property type="protein sequence ID" value="CCX32033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJA7"/>
    <dbReference type="STRING" id="1076935.U4LJA7"/>
    <dbReference type="eggNOG" id="ENOG502S3SJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWPRELP"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="493" mass="54605" checksum="4A70F559553878E3" modified="2013-12-11" version="1">MPIIQELSDSEDESATTSSSPIDLKTASSILHDTLTTLHTPTPSLEARYNTILHNLLPLSTFLQTQPSSITSFQPQLLQLLRPHPQLQPRLNYGFDDASYDASPALPHYHTLSTKLLKLLSSCESFLDSSDRELITTLAAFNSPEDPWTTATSQQLARGLLDTILGDEKGKGELYTPILRDVIKPLFSRTPSTSRITPAGRLAIRENSNNRIDTAPPLWLTERPEVVGVLEFILETIPAAQIEANWGLIVPPVLTLMDNTITSVKTRAVGMISTLLRRLEEEEGTRTLLKRTGLGTVFWDAVLATLSYLPPLTPVPESVMLLKAGYGCLIQLAKAREKELKKRALLLDAVVREGFLRGMRFADKFMDVVVVLVESLREVVTEMGVYFVKHLKSVVPVLGDLLADPFGDANLLLLGVVIKTTEVVVENCWMRMESYRGEILRGTAEGGEVERVRNGLRGLVRVVKATVREEEWGLIEEGIRGVDEKVFGGLFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJS0</accession>
    <name>U4LJS0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJS0"/>
    <dbReference type="OrthoDB" id="10316216at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="221" mass="25401" checksum="4255509B32249A60" modified="2013-12-11" version="1">MSAMLRLLSPSRSPSRLPADLTYDSYDLPPSSIIYHPNGCRTYLDTSNLSLRCLASLKAQEQKIVQYIFSQPVVLPFDLRTFFFSYRDPTPRALRSFSKTADRLFDSLRHMEAQMRTQGVKGFPDVVLGIVTPMRQGINILKKIYKERPKELRGNFDRIQEWISDLGAAEKAVGRVMVRAAKVLEESGEEEAVKVVREIRKLRLLKMAFALQIIFEDKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK12</accession>
    <name>U4LK12_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK12"/>
    <dbReference type="STRING" id="1076935.U4LK12"/>
    <dbReference type="OMA" id="AWVEGMI"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="362" mass="36627" checksum="90884B4E5C0962D7" modified="2013-12-11" version="1">MSSGSSMGLRRRSSRLSFGESINDDLRPQLGLAGPKSKTSKQLTSDHQAWVEGMIHHVRKASNERFRAGGAVSQSVVPSSWGGSVAGSNHGEQYGSQYGELDDDLLSPTQVEGNRRRSNSTRSVGGDETSRLPMPRQRERRDAETRRVFIKRGDTGTGRARVGSVSRPSSSAGGPPSTGLTRPPSSAGTRPSTSAGTRPSTSVGNRPGTAAGSRPGTATGKATGRPQTASGLPRPPSAGGFRPTSSGGPSASATSGIPRPPSSGGSGIARPPSSGGIPRPPSAAGYRPPSSGGIPRPPSSSSGGPTAPTGIPRPPSSGGIPRPPSSAGHRLSGGFSKRPTTSTGGYNGSRATSRDRSGAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKC3</accession>
    <name>U4LKC3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKC3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4721" checksum="6EC32EE14B6A8369" modified="2013-12-11" version="1">MPLQKCPPYLPLQFHHITTEHLQHTSNLCDYGSLLLNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKM2</accession>
    <name>U4LKM2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKM2"/>
    <dbReference type="STRING" id="1076935.U4LKM2"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="133"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="980" mass="108773" checksum="F34C587811A4EA39" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL17</accession>
    <name>U4LL17_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13489</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="13"/>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL17"/>
    <dbReference type="STRING" id="1076935.U4LL17"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KMHACET"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX32638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="981" mass="104752" checksum="3F05D358953F5A7A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLI5</accession>
    <name>U4LLI5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLI5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="14396" checksum="B5DBB5C62FF5926A" modified="2013-12-11" version="1">MKSTMIPPNLLSTTSSSWIAQERYYSPYVQLWLFYLFAAFKENEQEDDEMRMDDLDDFLEPYTEKTLEECGLDWEDPVQWPNVPAAKQAQAIRRLSLWMRWSQARATAHLIKMSRISVPVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMH9</accession>
    <name>U4LMH9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protein CbxX, chromosomal acc. no. P40118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMH9"/>
    <dbReference type="STRING" id="1076935.U4LMH9"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGDIPYE"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000159">
        <property type="entry name" value="p-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="315"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="593"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="844"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1095" mass="122752" checksum="14E5FDCC11EBD04F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMK2</accession>
    <name>U4LMK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMK2"/>
    <dbReference type="OrthoDB" id="10376008at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="204" mass="23972" checksum="FED0EA6BA78F2709" modified="2013-12-11" version="1">MIASDAQIRQDIAHTQSAILSLCDQIETIFIIRPRVFHDCPQSGTSNPCRCDLPAFHELPEFKRFRQSEIAYMKAQEEYRKCLVDQLRQCLKEIRNNDLKDYYKLYEHEVMDHVKAIQVAAGADLGLHQFRLQQLSRVLPLYELKWKKESLGKDRRASYWVKLFDEMMGELEIGGRDLGEEYRQMLLRSQQPEEHVTSLTVNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMQ5</accession>
    <name>U4LMQ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase acc. no. B7MPB4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMQ5"/>
    <dbReference type="STRING" id="1076935.U4LMQ5"/>
    <dbReference type="eggNOG" id="ENOG502SMET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WITGMDA"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF4">
        <property type="entry name" value="BLR0106 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="219" mass="24688" checksum="9A724B50A0BA88D4" modified="2013-12-11" version="1">MPCHYGYLRPHTPPLDYEHHSVIIMGAGPTGLLLGLKFAQQRIDVLFLEAEKEIATYRRACLYMPIVLKEFEKVGLLDAVVKAGAINTEGMAFRTPLGKDNRLLGCLLQTQVPKDRDSDLNNMVVHVGQNELAKIIQGMAEKYLHFQVRLSNRFTGCQQDEPGKVRVGVSTPKGEQFMEADYVVGCDSGTSAVWRALCIPFQRFTWNDFRLIATNIRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMY6</accession>
    <name>U4LMY6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to DNA repair protein rhp26 acc. no. Q9UR24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMY6"/>
    <dbReference type="STRING" id="1076935.U4LMY6"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTWTGQF"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000094">
        <property type="entry name" value="DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="435"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="801"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="6">
        <location>
            <begin position="1153"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="72"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134851" checksum="F00647439DC06B4B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMY8</accession>
    <name>U4LMY8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein TANC1 acc. no. Q6F6B3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMY8"/>
    <dbReference type="STRING" id="1076935.U4LMY8"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="206" mass="22840" checksum="30312FF4EB486E4A" modified="2013-12-11" version="1">MVDELLYRGQLGMAAKVQSVYCSSIMPTLTSETTIKEHRSLGPLLAHTPASHPYACYWSIVQISTPQCMTMVQISLACCSRGAHLQSSDYNGVTPLIHAASRRHVNVVDFLLEKGACLESSDRWEWTALTAAAYWGWEGVVRLLLEKGANCNLRDNEGKTPLAFIRYRLAAGDFQPGIFQFGESLINEKENLLSVGRLLERHGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN57</accession>
    <name>U4LN57_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN57"/>
    <dbReference type="STRING" id="1076935.U4LN57"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSCLDFF"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="179"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="664" mass="74916" checksum="D1AB827177032D67" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNI1</accession>
    <name>U4LNI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNI1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="264" mass="27859" checksum="0D5C3B8D98A73839" modified="2013-12-11" version="1">MFSTPKYLSTVFFLSAFSFTSHRYHSTIQCTHTTHTHFHSTSSTHNDLFSTNTIPIFIMKFSFLTLALAVSAFAMPHGDHSHQIEHQNKAVEAIKQDSSLVPHVSEHAPGAVDKPQDLDKVLADLLLSSYLKGEKGIIPADVLKAALNFHIVDHGHGELAYQDSGSVKNGSVVSVSATENNVDTGTTITVVKPVVDKTALTAEQLAAAFANTMTNKTMNGTAHGNTTAPGVPGDASKPNNAIAINAAFGAVFGGAVLAVIVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNM8</accession>
    <name>U4LNM8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Probable urea active transporter 1 acc. no. O94469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_09531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNM8"/>
    <dbReference type="STRING" id="1076935.U4LNM8"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LGANWLT"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX30930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="683" mass="73049" checksum="F792CF60D6863D1D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNN3</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="8505" checksum="A07D94BA88B0636E" modified="2013-12-11" version="1">MKVDVESAFVHSSIPETPGFFYNPRHTMVEYFLGLQQIEPALVEDKAKQHRLRRYQRLHVYTLARRGRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNR5</accession>
    <name>U4LNR5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative ankyrin repeat protein RF_0381 acc. no. Q4UMH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_14267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 100304</strain>
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        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="43954" checksum="56CF6FAFFF49C373" modified="2013-12-11" version="1">MALFLHILITYPVWITVSILKRRPELLHEDICGFGPPLRIAITICPVKGLAKEIIGLGANMYQRVHGLQPSFLGGLNRDDILQQVNWSPPVLKVELVVRTIFHEFAQWGNFGTSDLDLYHHFLQKWANINLEDDEGATLLHYAASGDNLPVFMALIQDGANLNCKTKRGTTVFYAAYQNSSLRVLAYLLKTSAVLIPSDISCSQLINSVSRAPNRKYLHGSTREDAKTSILRILPDKKYDITTRYYQPDIDIPSHWEKASRTRNKTEHFSSTGTGRYIAIPFQGIVLKRVEFKIRSCVFSRELGIHAWDQWNPRMYLYSWFEAATLRASIPKNTILGSDTKTKYALAVSHKYIQSNHDKTHVESHILISWDIWQPIPHIKQWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPY1</accession>
    <name>U4LPY1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Pc21g01340 [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002567204</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPY1"/>
    <dbReference type="STRING" id="1076935.U4LPY1"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="393" mass="43388" checksum="41CFFD5A87ED087F" modified="2013-12-11" version="1">MATITAISTTNGGTNGNSEQAPPKSRAPEALQTSRKITMAALLMLPLSTLGAYKFIFSPIGTSINLHITAVFSTGRFPFSAPPGDLLGDPLLSRFTPFPLFDLILAYFTSFFHPLISWVNQPETLFTLYFLSLLLPTFIIIAQLESSRRQTPTTLRYPAAWNMILIQLSGFATGAPAWYSCSLFKPATGPVDLAAAGAVLPAVILGYGTVTAMMFLPGLEATQRQWWCAVWQFWPFYVAVIQWVLVSSGIGGWMAKRGLGVKRVWKILIVVGGIVHWRMMWGAGIKGGMFWMAEFQTDAVVSLAGATGLLIWWDFWIGAVASAVWAWARLGRMRGGVMREVLKQFGTAVVLDVCMVVGGPMAVLAGVELWREENKEMVEEERRRKEAKRRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ79</accession>
    <name>U4LQ79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ79"/>
    <dbReference type="STRING" id="1076935.U4LQ79"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="142" mass="15712" checksum="4AE09E12C0B055E8" modified="2013-12-11" version="1">MFGANPAPPPTPQYPPQTSSPVVATAAPQAPQGTLAQFTPGATRSKQLARICLDIVLEKTEAKAILLSPIMKQRVTLLLSSPKFINSLQNVDGIFTGLFLMGCDINKARALWHQRFIIYQNYENSLANDYTLKEYYNVTPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQD1</accession>
    <name>U4LQD1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Vacuolar protease A acc. no. O42630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_01850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQD1"/>
    <dbReference type="STRING" id="1076935.U4LQD1"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652280" evidence="13">
        <location>
            <begin position="19"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="86"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="396" mass="43193" checksum="A40C225AEFF77DBC" modified="2013-12-11" version="1">MKAFGILAASSLLGSAFAGMHRMPLKKVPLSEQLDGYDISSQVRALGQKYMGIRPKQHSNEMFTTQSVEALDGHSVPVNNFLNAQYFSEISIGNPPQDFKVVLDTGSSNLWVPSQQCGSIACYLHSKYDSSASKTYKSNGTSFEIRYGSGSLSGFVSRDDVTIGDIHIKDQLFAEATSEPGLAFAFGRFDGILGLGYERISVNGIPPPFYNMVEQKLVDEPVFAFYLGTTEQQSEATFGGIDKSHYTGELIKLPVRRKAYWEVDFDAITFGDQVAKLENTGAIVDTGTSLIALPTTIAELLNAEIGAKKSWNGQYTVECSARDSLPDLTFTLTGHNFTIGPYDYILEVQGSCISAFMGMDFPEPVGPLAILGDAFLRRWYSVYNLGDNSVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQJ3</accession>
    <name>U4LQJ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized membrane protein C20F10.07 acc. no. O42976</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_05647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQJ3"/>
    <dbReference type="STRING" id="1076935.U4LQJ3"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSGNMIS"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQQ1"/>
    <dbReference type="STRING" id="1076935.U4LQQ1"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NFETCYK"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="194" mass="21267" checksum="84DA1AC81482A1DB" modified="2013-12-11" version="1">MASTISNPPVIVLSGPSGTGKSTLLKRLFADHPESFGFSVSHTTRGPRAGETDGVEYHFVTPEKFQELVAENAFIEHATFAGRSYGTSIAAVKDVTKQGRACILDIEMEGVKQVKNSDLNAKFVFVQPPSVEELEKRLRGRGTETEEAIQKRLSAAIKELDFAAIPGTHDKIIINDDLERAYKELDDYIMGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQT0</accession>
    <name>U4LQT0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec3 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQT0"/>
    <dbReference type="STRING" id="1076935.U4LQT0"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 coiled-coil" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="15972" checksum="FE1951EC5D5ED493" modified="2013-12-11" version="1">MKAVLLSDSSKPAGRCSIIRLVIWRAGSLRDRTDWATVDFQKYIPDIKNSKKGWLKFKNSLKKFQGESDADLHGRRREPMARVESSNVVVSMDDDDRINQLSELLDKAIQECEEIDGLLTLYAVELSSLNDDITLSTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQU2</accession>
    <name>U4LQU2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQU2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6247" checksum="1264499610B81456" modified="2013-12-11" version="1">MPPLSPLHSQSVARCYSTPCCRGEYWRRIPLALQTRRQQLQPPEISASGETSCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRP4</accession>
    <name>U4LRP4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX32005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRP4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="19" mass="2178" checksum="B0C88D2A4640BE6A" modified="2013-12-11" version="1">MSCYELHALLRSLMGLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRU8</accession>
    <name>U4LRU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to E3 ubiquitin-protein ligase MARCH5 acc. no. Q9NX47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRU8"/>
    <dbReference type="STRING" id="1076935.U4LRU8"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="37064" checksum="458FD5A6AE26F414" modified="2013-12-11" version="1">MDPEFDFASTSSSYQPTASQASFRFAPPTDTARIGNYRRPFVEDVPEPRLHRPPTPPASTNEAPDGPDQLRQCRICFDTVPPPYDPSPELGRLISPCICRGSSRYVHAACLQTWRETSSQAFYTCPTCKYAYRLRRLSYASLLSSTGTTFAATSGILLFVVWALGFVSGPILAAYLDVAVPSNIEFPVKPGGWAEHFLRGLASLGLLGFFKVIYLVGPSSWWSFRNSGMMGRRDRVSRLTWIVIALGVANFFVWLWRRVGDVVKRRMDKMAVEVMDIGEGGDGEVREEERVPWKVWFAQEAARLWQGAQDVGRGFMRGDTGDGGIGGIGGIGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSC8</accession>
    <name>U4LSC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSC8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7466" checksum="CCAA57B07C1ADB8A" modified="2013-12-11" version="1">MPRDAYLAILDRLRQDRQDIFGAECMSTSNAISRLFGDHRDMSELVMIKAQIRRLLVAAYLHNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSD5</accession>
    <name>U4LSD5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Opioid growth factor receptor acc. no. Q9QXY4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSD5"/>
    <dbReference type="STRING" id="1076935.U4LSD5"/>
    <dbReference type="eggNOG" id="ENOG502S3JY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="563" mass="65685" checksum="A3D5F5FCBA7F99E5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSE2</accession>
    <name>U4LSE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to TBC domain-containing protein C1778.09 acc. no. Q9Y7J5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSE2"/>
    <dbReference type="STRING" id="1076935.U4LSE2"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ELETSWM"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="548"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="820" mass="90699" checksum="249EC60282F51DD9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSI6</accession>
    <name>U4LSI6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to UBX domain-containing protein 7 acc. no. P38349</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935431">
        <property type="protein sequence ID" value="CCX30266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSI6"/>
    <dbReference type="STRING" id="1076935.U4LSI6"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEPNNTS"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="286"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="468" mass="51253" checksum="8BFC10447FAE9B1E" modified="2013-12-11" version="1">MSTSPERTSIFYSGTVHEAIATSVQQRLSLVCFVTDGGEEASIWESEYLLDSEVFESLKTDAILLRLQAGSEDAGLLAAVCPVEEIPHLLVTRGGTLLLQLKPGVSRQEFTSSLKSAIARPPASTRSPTASVPQTQVQPQSQPLPQLQLQTQPQPQPQSQIQAQIQTHTPTQTRSGPSYAQNTPLTPAPAASPISHGNPNTPIPTTPATPVGESSVATSHSHIPSYLEQQRQKKQAEKAERERILQRLENDKAERRARDRERRGTLVTPTQSSRPQSLEPLFSAEIALSFRLTDGTNIKSRFSSSVSLGTEVRAWLDQNREDGRQAYDFVEILSPSNNRSLGISDETLPLSSLFKRSATLVLVPTQTYTSAAYENPSISSHTILSQAYGLISGALDAVWRLGSFAPRTEETPPPPPRRQTLGGDPRRAPPGRSAPNQVRTLRDQGEEKDERKYYNGNQLSFEPKPDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSN6</accession>
    <name>U4LSN6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to NFX1-type zinc finger-containing protein 1 acc. no. Q8R151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSN6"/>
    <dbReference type="STRING" id="1076935.U4LSN6"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFTQARK"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="472"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="807"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142589" checksum="3DAA55E7E550F639" modified="2013-12-11" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT46</accession>
    <name>U4LT46_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT46"/>
    <dbReference type="STRING" id="1076935.U4LT46"/>
    <dbReference type="eggNOG" id="ENOG502SEKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PKPCQYF"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6590" checksum="0416DFADF73CF7A9" modified="2013-12-11" version="1">MPEPSHGGLRMLSLDGGGVRGISELVILNELMLRIQHRLQLSELPKPCQYFDIIGGTSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTS9</accession>
    <name>U4LTS9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTS9"/>
    <dbReference type="eggNOG" id="ENOG502SWAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5375688at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17623" checksum="ED27563CE42C0225" modified="2013-12-11" version="1">MAAYTLPSGQKVIFLYEDRDQSYKGRGIEDHLKVLECFAAIWNSNYPDKCGRFPSLSATNAWPAGAIVVSSGHHKSNHSIGEDQHITAYVCSEAGWNSVPRRSNACVHIYSMDEDVSMGFMGYWIKNSNSNNFKSKLVLEKLQRALENERKMPPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUA7</accession>
    <name>U4LUA7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Alkaline phosphatase D acc. no. P42251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUA7"/>
    <dbReference type="STRING" id="1076935.U4LUA7"/>
    <dbReference type="eggNOG" id="ENOG502QU5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SVHPEIH"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF7">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652384" evidence="1">
        <location>
            <begin position="19"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="195"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="628" mass="70835" checksum="2BE81A5A0F64680E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUH5</accession>
    <name>U4LUH5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUH5"/>
    <dbReference type="STRING" id="1076935.U4LUH5"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="204" mass="23109" checksum="70DA8043D0FE9FDF" modified="2013-12-11" version="1">MDNTCRACGQQFPHVYRNGFICFDIKFLRFFKLRDHGHQDAGTVNLEYTEEFLNTETPGLEDYSKPSTDLNPPIVSLPVVDGKVDLDFVSRKAWKGSCCAVCGWLNSQNSWEVFTAKVTRIFTPIDLADDHRYLYTGYAIIEDEFAPEISANDQPRSIESMAVDCYGGYSLLSTELLAETSKFMREIKKVVENPLELLVRGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUT3</accession>
    <name>U4LUT3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to General amino acid permease AGP2 acc. no. P38090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUT3"/>
    <dbReference type="STRING" id="1076935.U4LUT3"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWYGESE"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="47"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="554" mass="60773" checksum="533C2C78F74C0138" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUT6</accession>
    <name>U4LUT6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 60S ribosomal protein L9-B acc. no. P51401</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUT6"/>
    <dbReference type="STRING" id="1076935.U4LUT6"/>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="192" mass="21324" checksum="D17A0885948A3BA8" modified="2013-12-11" version="1">MKYLHSSELLTIPEGVSVSIKSRVVTVTGPRGKLVKDLKHLAVSYVPKGANQISIELHHGVRKSIAALRTVRTLIENLITGVTRGYKYKMRYVYAHFPINVNIESVEGTPVVEVRNFLGEKIVRRVTLLPGVEVETSANVKDEIVLSGNSLENVSQSAADIQQICRVRNKDIRKFLDGIYVSERGNIVESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUX6</accession>
    <name>U4LUX6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935722">
        <property type="protein sequence ID" value="CCX32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUX6"/>
    <dbReference type="OrthoDB" id="5425965at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="594" mass="66729" checksum="340DC74596616377" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV41</accession>
    <name>U4LV41_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935728">
        <property type="protein sequence ID" value="CCX32196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV41"/>
    <dbReference type="eggNOG" id="KOG2676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHEIDDH"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652418" description="Ataxin-10 homolog" evidence="8">
        <location>
            <begin position="22"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Ataxin-10" evidence="9">
        <location>
            <begin position="591"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="714" mass="80152" checksum="DDA33B8FAF2DB67F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVI2</accession>
    <name>U4LVI2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to WD domain-containing protein [Ajellomyces dermatitidis ATCC 18188] acc. no. EGE77513</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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                <person name="Marcet-Houben M."/>
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        </source>
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            <dbReference type="EMBL" id="CCX32591.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="33" mass="3682" checksum="478FEFD84CE34A71" modified="2013-12-11" version="1">MNKLTSWNPLDLKMRTVSLAVFQLALSMGSQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVV1</accession>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX34897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6208" checksum="5EAC812F89E698B8" modified="2013-12-11" version="1">MNPFDHVVLSVRFVLYTYTDPKRLNKQIQSTNCSFSSFCPQSEASSHAEIPIGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWM0</accession>
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    <protein>
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    </protein>
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    </gene>
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        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19421" checksum="B8E73BEF19D8E3F5" modified="2013-12-11" version="1">MPDMANTALAEIRNMTLVFEELHGLIKQEEQSPGSNRIFFDDRLRNALQDIESALGKIKEELGELGGSPDMNFSERKEWWKKEPTIKSHFDCLNWHKSTMIMLLTTVTCKSTLKTERAIAEMQDHMRQIFQTPSDCTIEFVETTAVASFQLDVLKVGYLGHELSLDPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXR8</accession>
    <name>U4LXR8_PYROM</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX34593.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTR4</accession>
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    <protein>
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        <lineage>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="CCX04283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUC9</accession>
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        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="11 12">
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCX04888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUC9"/>
    <dbReference type="STRING" id="1076935.U4KUC9"/>
    <dbReference type="eggNOG" id="ENOG502RYIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHSWSCA"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="695" mass="76708" checksum="A2D5EEB6433311EA" modified="2013-12-11" version="1"> </sequence>
</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <source>
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        </source>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="13381" checksum="ABBCBFC82D12CC45" modified="2013-12-11" version="1">MGNFLGRLSCMRREKYEVIPRSRGPWRHQFSHHIAAQQVKVFSISSSQAPPSTVSSVGATRDGSVWGVPHYLSNRPTILDYPWEMMEEQAWEDGFYIKEGGYGHLNEAYYSKDNVLA</sequence>
</entry>
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    <accession>U4KWX4</accession>
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    <protein>
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    </protein>
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    </gene>
    <organism evidence="1 2">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX05756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2539" checksum="3C3BE17B7688EEE5" modified="2013-12-11" version="1">MHARYSDSPTYASIVVMDLPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX18</accession>
    <name>U4KX18_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein sum2 acc. no. Q9HGL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935291">
        <property type="protein sequence ID" value="CCX06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX18"/>
    <dbReference type="STRING" id="1076935.U4KX18"/>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYPPPGH"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="595" mass="62910" checksum="0A10ADB164DA05C8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX47</accession>
    <name>U4KX47_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX47"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2284" checksum="90E1F6858A340A48" modified="2013-12-11" version="1">MRKGKPGRVPMAIRFVRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXJ4</accession>
    <name>U4KXJ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXJ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4398" checksum="18FA114509340E9C" modified="2013-12-11" version="1">MRQCWLLRFLQQNTAELLPTVSSVACVFELELSTKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXV5</accession>
    <name>U4KXV5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Ethanolamine utilization protein eutQ acc. no. Q9ZFV5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935308">
        <property type="protein sequence ID" value="CCX06691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXV5"/>
    <dbReference type="eggNOG" id="ENOG502S3HA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTYHAKA"/>
    <dbReference type="OrthoDB" id="4985585at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02228">
        <property type="entry name" value="cupin_EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13234" checksum="A1EFFAC30C327A30" modified="2013-12-11" version="1">MPQMHYHPKAQSTFKPPLIANNNAFLGDVFSSEKLNPEKPISAGFYRLEKGEPLVYTYTYDEMKIIVEGEYQISDETGQSVTAKPGDVFYFEKGAKITFSTPDYGLAFYCGQRAKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXW0</accession>
    <name>U4KXW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Calcium-independent phospholipase A2-gamma acc. no. Q8K1N1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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                <person name="Gabaldon T."/>
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                <person name="Gabaldon T."/>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX05254.1"/>
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    </evidence>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX07769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZW7"/>
    <dbReference type="STRING" id="1076935.U4KZW7"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="90"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="321"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="706"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="850"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="937"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07769.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1165" mass="134275" checksum="4F227DCA2C4550FA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0G9</accession>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="60"/>
        </location>
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        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="12345" checksum="EF397DFEBCF40D93" modified="2013-12-11" version="1">MARTCSRPATITEASNIPAIRGNKHPQSPNDEDFKPRKRYLDEKTIGETRRSNGDDYPMETTAEFYPKAFDSAEEDEEKNQKVLGYFVTDKADHSNELEKKPMNQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1E8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07895</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="268" mass="30106" checksum="4972024FDCE00449" modified="2013-12-11" version="1">MPSVPGSPPRHQLISISSFLHQLHRDNTKLSASLEDLRELTSTLERKKAQLLQKKMLQIEQEKEQFMQRSTFILEPPTELTTPRKPRLVEQQLFKLSDVEASAAAETQRKRTIMRSPEAPIFGLVIPPPVPKLPDLSGFPGFPFLQPPPGLPARPATAPLPRLPAPPGFPDIPGSPVFVDLPPMPETPRVRHQSMDKIRKLRFTEDTKPAVDYGKPKMRRNTHGDGKRVIMEEFDVSAEIEEMMVDIQKWCEEADCDEAGFEGVGVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1R6</accession>
    <name>U4L1R6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to AN1-type zinc finger protein 1 acc. no. Q8TCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_05765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="304" mass="33332" checksum="98326E187D882513" modified="2013-12-11" version="1">MSTAEERAEILANADFAGIGSHCDLDTCRQLDFLPFTCTYCKGTFCGKHRSVADHSCPKYDSAAAERAAAAARAASVSSYRPRPTSMLAGLCAATRCKININTATQPGVNCEKCRKQYCITHRLPDTHDCKPPSIPVMNLAEEKGKAALEWFKKVTTETKKMEEKTGGGLLGAFGVQKKPPPKTSVAAVMKMKKEAKGDEKVPVPKRVYVHVEAEARTATARIPRGVFWYSKEWKVGRVLDAAAKSLQVTNVNNQVDSDEKKLRIFHVEGGRVLEFNEMIGDIAVDGNTLVLMRGLQMPDLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3C3</accession>
    <name>U4L3C3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3C3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9023" checksum="30B3CE132D0DC8F3" modified="2013-12-11" version="1">MPIGGNTRADSKQGCDPFNPSLPRRALENGIHPAVENCATPRLLLSIGFILIISQKIKLLDVRYQMRRRSPEHLMTNLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L459</accession>
    <name>U4L459_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935586">
        <property type="protein sequence ID" value="CCX11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L459"/>
    <dbReference type="OrthoDB" id="10531322at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="435" mass="49636" checksum="70E11BDE66CA8590" modified="2013-12-11" version="1">MTEPRDDTVVERPQIEDYFSFVPYHARKKTAKKKAKDATIVTPRPVPPSPSEEVNHTTPSETKNASIVTPKPLSYTPFDELDNKTTKAAKSVSIITSKTVSPNPSEELDPAIETASFATPKNLSRNPSEEALKTLHESPISEVTTRSESSHGTSSDTSSDTSSDTSSDTSSDSSSAPTACNSVEDLRLHDASDEHLAKPTTPADTATATPSGDNPKHPGLQTRRTVSSSVLTIRQPHSWDFSSQQPIIVPPTSYNSSHNATSDPRERRLAVHAVRDDDDDDEEGIYFPPFPEERHTILSTIVDTYRQKKWQFMDKHYKYNAWGDDDAVRYFNEMVQYRKHNSVSNFTVKMCRYLKLARKLDKLRWKFVSWRQRNVVLREDYAEKANLERVNWLIKEGLIIPECKPPEYRKKDPMRNPRYRVHMEEYARIKQHQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4R4</accession>
    <name>U4L4R4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Non-structural maintenance of chromosome element 3 acc. no. Q9Y7U4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4R4"/>
    <dbReference type="STRING" id="1076935.U4L4R4"/>
    <dbReference type="eggNOG" id="KOG4562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KITYSWG"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="58"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="320" mass="36257" checksum="BE03BCEAB35449BB" modified="2013-12-11" version="1">MPPSSSRKRQLPNSESTPASSRKQRRVAVVEDSPEYEEPHQAGIDDDIMQTQGGNIQVDRLSKNLVRLALAQELQRQPLKRADVGSKVLGPNGRMFKDVFALSQKDLSDVFGMTLTELPVRDKTKLSQRRAAASSSSTATSKNYILTSTLPSEYRIPSIMSPSSFQDSTYLGLVSFIVGLVYQNGRVLPQNKLYRYLKRMNADEYTPIGTTEKVLQMMQRHGYIVRVKDTQGDETSYDYHLGPRAKREIEEEGVLEMIKEVYGEDTPKDVERRFKVNVGVEIKAGFEGEEEEGERSTQKSRRKGKQPARKQREETDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4V8</accession>
    <name>U4L4V8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to BTB/POZ domain protein [Talaromyces stipitatus ATCC 10500] acc. no. XP_002488366</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4V8"/>
    <dbReference type="STRING" id="1076935.U4L4V8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="289" mass="33009" checksum="E4BA0ACFAE995352" modified="2013-12-11" version="1">MAQNGLNHLQVPPNNRGRARHSFHPGSNTGYFGPAQCTSCEEFAARRATLPPFFTGSYPLTIDEQVHEQHLKMAKERDKLAFLNEYEKIFNNPKHSDLTINCEDRTFYVHKIILSLRTQFFDNATDPYSNFVESNGVVTIQDHCADSVYCFLKWCYTGTYDITTLDIQEKHLLHIRVYAVADMFLCNALKTLAIRQLQKQMNFNWSAAEFPSIVAEVYEVAGPSSAAPDMLRKTVVMKKYGEFSAALVRINASKGTWEMINQFEMRSQGQMGEFGRRNGWYVGQAGRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L520</accession>
    <name>U4L520_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10554</name>
    </gene>
    <organism evidence="2 3">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
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            <begin position="28"/>
            <end position="38"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="27738" checksum="D3A36DB26BA7846E" modified="2013-12-11" version="1">MNDQNSSDDNHREVVQQALVDVGNYTNDPRDLLLHEEPCAYNGSSNHDDSSDCEGVSGQEEVSDHDDGSDHDNASEDDDSSDDVYPYGEDETDGFELREGLEYFIEHEQSGLTYRACRNNHPKNQINPEDITLVGDEVIPEYRDAKYPGVFNPDYDTYVSHTFAPGTPNERTQYFLIKKRLPDFETEEEFHLAVSRMMGLGNWVRNPGAGHLMRLSSLPYAARYAQWITIDPNAEEIAPAMNAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L808</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_12542</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX12948.1"/>
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    </dbReference>
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            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="305"/>
        </location>
    </feature>
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            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="131"/>
        </location>
    </feature>
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            <begin position="149"/>
            <end position="162"/>
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            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="33717" checksum="730A4A5DF86C94DD" modified="2013-12-11" version="1">MAYYPPSHTAGSPPAPLTPWFLDGEGIEHRVVQSDIPRYLGNDATVKRGQRDAMVRSLKDDSERYNNERRETRRRQGQDEVDYHVSKTFYDSLRRPIHEQAPMPSQNSAIELPSSREPPINPVYGFPPPSQYPSGYSSGYPPHPGDQYAQHTNPSSSREPSYQQPPIPYGRGGTNGRGRHEGAPIGNYTTQAAGNPYPSQPIQGGSRPTDGYSAPIDPRYSGDVYVPTVEPVAVPYGARNTPPGHQAGHQSGHHSGHQIGHQSGYQSGHQNEDTYHYEAEHGSWRGNREAPQSYGRGHARHGDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8I2</accession>
    <name>U4L8I2_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to ARS-binding protein 2 acc. no. Q9USY4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06041</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06454.1"/>
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    <dbReference type="eggNOG" id="ENOG502QV85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2104370at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="705"/>
            <end position="739"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="747" mass="80724" checksum="F18054FB973BB71E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA05</accession>
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    <protein>
        <submittedName>
            <fullName evidence="6">Similar to 30 kDa heat shock protein acc. no. P40920</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">PCON_02808</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA05"/>
    <dbReference type="STRING" id="1076935.U4LA05"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VVAPKHQ"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
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        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
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        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="44"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX16212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="197" mass="22403" checksum="B6C75C1F1FF22078" modified="2013-12-11" version="1">MPFFPRFHYPAETNAHYTAFPTDILRMFDEIDRATSSGSSTSSTSRRAFSPTFDVHETEHEYVLEGEFPGLSDKNNVSIEFTDDKTILISGKIEREFKGWKDEQGKLESAEEQKKIEGGQTTAGQEAEKSDKKVEKKEKLKSPKYWVSERSVGEFSRSFSFPGPVDIDQVKASLEHGILKIVVPKMEKRTGRKIEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA91</accession>
    <name>U4LA91_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C227.17c acc. no. Q9UTC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA91"/>
    <dbReference type="STRING" id="1076935.U4LA91"/>
    <dbReference type="eggNOG" id="ENOG502S4MN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGGQWVN"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="20967" checksum="A523697A26C65C14" modified="2013-12-11" version="1">MFWSKPNPPTDAAAATPAPAPAPTPAPAPAAESKPAPSSSNADRESSADKDLAALMAELDAEHKANALAARHAERVHITEEDKTGLETDMNCLTAFDEMFYCYSFGGQFLNIYRYGEFRDCSEKSADWRFCLKAKVRGEVAKRAMILQRNKEKAAKYKTAKSSEDIWKVRKTPLTDAFAGDIEEVTDGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAG1</accession>
    <name>U4LAG1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935567">
        <property type="protein sequence ID" value="CCX10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAG1"/>
    <dbReference type="STRING" id="1076935.U4LAG1"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YTLWIIV"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="9950" checksum="ED3FE0E27BF44664" modified="2013-12-11" version="1">MLAALAGISMILVATAVFLYYTIWTLFMPFVDENIELHNFFPPRVWAIRIPLAIVLVGVAVVGSFLSMVMIKAGQKKRAKLAAAAGVKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAL3</accession>
    <name>U4LAL3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Tyrosyl-DNA phosphodiesterase 1 acc. no. Q4G056</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935341">
        <property type="protein sequence ID" value="CCX07199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAL3"/>
    <dbReference type="STRING" id="1076935.U4LAL3"/>
    <dbReference type="eggNOG" id="KOG2031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="892"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="998" mass="109349" checksum="749D057F16F03D37" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAN8</accession>
    <name>U4LAN8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_10497</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935574">
        <property type="protein sequence ID" value="CCX10903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAN8"/>
    <dbReference type="STRING" id="1076935.U4LAN8"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NFQMEPF"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="15">
        <location>
            <begin position="355"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX10903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="515" mass="57978" checksum="A2929BABE2CEFCD6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB22</accession>
    <name>U4LB22_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936243">
        <property type="protein sequence ID" value="CCX15615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB22"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3821" checksum="B93F8D886D8DD5FC" modified="2013-12-11" version="1">MPSCRCFDYICLFLRKLLYRDASVFAPPNPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB44</accession>
    <name>U4LB44_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UPF0676 protein C1494.01 acc. no. Q7LL04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB44"/>
    <dbReference type="STRING" id="1076935.U4LB44"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWHVGRE"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="208"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX15841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="40948" checksum="308826C69D37C32D" modified="2013-12-11" version="1">MWGDVEVLYRHLTSSTFDIIDPQDIMMLPEAVATGVEKDGLFIPLIDFGLFLHGTETDKAAVVAGVSSGFKNAGFIYLKNHGIPPSSISSVFASSKSFFSRPQEEKDALKWLTPESNRGYVSPGREKVTQSTDAAEIAALREKHPDLKESFEIGRDNHPVLLNNWPVEEATSEASFRQTMTAFYSTCQSLHIQVMRCLALGLGLQEEHFDSFIDAADNNLRLLHYPATPASVFKQNVGQVRAGKHTDYGTITLLFQDTRGGLQVRGPQGTWVNATPIEGTIVVNAGDLLARWSNGKIMSTEHQVVEPPSEPEEGWHPARYSCAYFCNPNAEATIEALRGTYEKEEDKIWPAIRADEYLVQRLTKTYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBK2</accession>
    <name>U4LBK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to 54S ribosomal protein L12, mitochondrial acc. no. P53163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935363">
        <property type="protein sequence ID" value="CCX07692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBK2"/>
    <dbReference type="STRING" id="1076935.U4LBK2"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="18587" checksum="B406203801446D2C" modified="2013-12-11" version="1">MSLASRCCARLARATRPTTFTPLSALPARRFNSTDAAVDPKISAIVDQISQLTLLQTAELVSSLKSRLNIPDMALQSFAAAPAAAGGAAPAAVEEAEEEVVQEKTMFNVKLVSFDAGSKPKIIKEVKSLLGLSLVDSKKFVESVPKMLKEGLSKEDSEKIQKTLQDLGAKVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC83</accession>
    <name>U4LC83_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Initiation-specific alpha-1,6-mannosyltransferase acc. no. Q9UTR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC83"/>
    <dbReference type="STRING" id="1076935.U4LC83"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="546"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX29704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="641" mass="71306" checksum="62CA9D0AC0874B9A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCK5</accession>
    <name>U4LCK5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936491">
        <property type="protein sequence ID" value="CCX16636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCK5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4442" checksum="6561EF2C05D6F75D" modified="2013-12-11" version="1">MPSCSNDSESKGNWNCPVSHMRGTSDGVLMCEPLRSIRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCL0</accession>
    <name>U4LCL0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935400">
        <property type="protein sequence ID" value="CCX08231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCL0"/>
    <dbReference type="STRING" id="1076935.U4LCL0"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="27633" checksum="4960717287E6CCFE" modified="2013-12-11" version="1">MKILTDCYAQTEVEEMESYNHINLSGCSPKNTMLLDNHNLTELNSGSFASNIPWPEMPRLLYPTNRPSPLAELPIPPDSLVITEDSPLERWYSSSSEDEGCTIKALATVASSLLPPELHATRADISSGSSLGSARSIGSHQSLSSRRKQRYLFRTTTTAALAIDTDTIQPKEEEQEPNPFNGPSKGKAKAKAKHKTAPSGPKEQKKYQCTFCTATFTTKGNWNRHEASVHLLSDTWICAPDGPWDKKKNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD54</accession>
    <name>U4LD54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Sec14 cytosolic factor acc. no. Q10137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935416">
        <property type="protein sequence ID" value="CCX08478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD54"/>
    <dbReference type="STRING" id="1076935.U4LD54"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQYYPQY"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="97"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="309" mass="34986" checksum="B0496421CC10C56B" modified="2013-12-11" version="1">MAVDSKYDVFTYPTTNPESGAGHPGHTTPEQDELVAQLRKELEADGFTDRLDTLTLLRFLRARKFDVALAKKMYTDCETWRKEFKVDDLVKDFTFVEKPQVFEYYPQYYHKIDKDGRPVYIEKLGKINLTTIKTITTEERLIQNLVVEYERLANPRLPACSRKADKLLETSCTIMDIGGVGIQSMYSATEFLKKVSAISQNYYPERLGKLYIINAPWTFSTIWNGIKVFLDPVTVSKIRILKGPSEYEAVLKEQIPAENLPKEFGGLCECQGGCQLADAGPWNDPQYMEPAVPAATTTAAPAEVTENQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDD2</accession>
    <name>U4LDD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Cellular nucleic acid-binding protein homolog acc. no. P36627</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDD2"/>
    <dbReference type="STRING" id="1076935.U4LDD2"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGNPTCY"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="209" mass="22407" checksum="DF882084A716EBDA" modified="2013-12-11" version="1">MLQCWLGSLIGCSVTKPRVPSLPYDTSLTQLKWNSVVLPTPRRPVPATTARDCPKRGTPVCYNCGQDGHMSRECTGPAKEKTCYRCGQTGHLSRECSQPSTQGEGGFGQGQASECYKCGKVGHIARQCSANNGGYQGGNFGNHGAGRAQTCYSCGGYGHLSRDCTQGQKCYNCGQLGHLSRECPSEQDRVCYKCKQPGHVMAACPAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDL2</accession>
    <name>U4LDL2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Kinesin light chain 2 acc. no. Q9H0B6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDL2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="44648" checksum="0F76D06AC62E3E83" modified="2013-12-11" version="1">MNAEREEWVSEWAAVEGLIKQFQVSVWKLQNREWRFRAKGMEKLQASIDVLERVQEEMVYPWGLTDLQIQDRITILTTQLSSDDAPPLHPDTTPIPLLSELSYLHRHLENYTPAQTILQRLITVKSQIHNRISPYDFSTCAKICQHLFDPIHNLTEIRKIELAAYSEGTCLTLSYDRDENGDRRYHDHDRGDTDEDNVTEDSDSGIIANPYSVTALLQFATTLRRTRWYKTAEKMLLKLRGEVEKAMGKETFEFSGNLLALGELWFHLSRFKEAEMVFLEAVEIRRRLFEEQPEGHILGHILGKRAIDKVGTWLLEVWTRLGKLWNVEWVLRRRLKAAEEGEDGHHAMQGMMQLGRCFMDQKRWEEAEGFLRRLLRLGIGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDL8</accession>
    <name>U4LDL8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDL8"/>
    <dbReference type="STRING" id="1076935.U4LDL8"/>
    <dbReference type="eggNOG" id="KOG2486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LCYYWDT"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="173"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="39244" checksum="AAE38D6AB6A5D463" modified="2013-12-11" version="1">MGEKTSRPAQSEKNRKEEKAAAERGEVREDDVLVQAVRPEKKGRRGKGAGLATVEEDMMTKFNPRAEPTEMELEAMKEAGLRPRPEVRDMLGEVITEGLEGNLDQELQGGAGGFTGELKGKKGLVKGMTENIYRWDTEPPTGGQLKRADKFFKDHPVKHLWTEARFREIEMGESPEVAFLGRSNVGKSTLLNSLLEKGLAQTSSKPGKTRLFHAYGVNQGKIVLLDMPGYGHASREAWGVEIMKYLTGRKQLRRAYVLIDSQHGPKASDLMILESLGRANVPYQIVLSKIDRYIFTHSSLKTALLDTKYLLDSGIGGVSGLGEIIGVSSLKKKMGISELRWSIMSACGLEGWRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDW6</accession>
    <name>U4LDW6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDW6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="111" mass="12075" checksum="8CD45811D3EF247D" modified="2013-12-11" version="1">MNSSFTTMTSFPAAAILSLASGSGDPAQHNYGYTLYATMVAMAMPALWTGSAFVRGFAAATFDFSWHLCGVDSWMRCFFDDMMVFHLVPETTVFISGNISSQDIQGTMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDX0</accession>
    <name>U4LDX0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Transcription factor steA acc. no. O74252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_08877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDX0"/>
    <dbReference type="STRING" id="1076935.U4LDX0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMSRHGT"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX09284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="641" mass="72741" checksum="A9C5AE07755931C0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE08</accession>
    <name>U4LE08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE08"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="185" mass="21485" checksum="24990BA9832F2790" modified="2013-12-11" version="1">MNTSEGIWNRWWNTLGYCKFTFGIFWGWVNASRLRTQGVAKAISRFSPTRAKVRAYTCHPQYVQSKMLFKIGIQTKIVFADLGWAKLGSPRTRYGYHEYRYYSKSLIFRKSANTEYSGPAKLWIEGRADFPPSPLLSGLKSCTNVTTPRHAGYVPARCHLRHRLWPASCYINQPLVLWQRLTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE16</accession>
    <name>U4LE16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Zinc finger protein C144.02 acc. no. Q9UTM0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE16"/>
    <dbReference type="STRING" id="1076935.U4LE16"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QEQVTVC"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX30113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="287" mass="32442" checksum="281F9F329289CB58" modified="2013-12-11" version="1">MSSPPSSPLSPYSSAPSPPRKRRVSAIFTDDEEHSGPGAEVESDISSDTTGSVPNSPGAFDPHDDDPAEQISICKWDGCNMDLKNMDDLVKHIHEEHIGTRKATYACMWDDCTRKGMAHASGYALRAHMRSHTKEKPFYCSLPECDRSFTRSDALAKHMRTVHETEALRPSDPVPKSHPNHPLNHPHLSRPPAPKPSSTSNISPDKFYAAEDGYSTDEEKLPPRELYRLLRQKQSWAKQEAEELKETLGKLQRRRREAWVKKEMLLDRVLDMELGEEEARSVSLDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEQ1</accession>
    <name>U4LEQ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEQ1"/>
    <dbReference type="OrthoDB" id="10275211at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21938" checksum="28637101D3DD810D" modified="2013-12-11" version="1">MAFPKSSTGNSNRTNRSPQKRKQEEEVVGESPLDEYHLFIYKVNKDQNLKEHRTVPHSYDMYGGSAKRVGKDYERFIKASNKAHPGETWYGGGDVTLFRDDEGDPEDVRGITAPQVRIEDIPGQRMMRPKHEIIKMAKSAGYSSAEIAVWGDTIMESDITPDPEGWQETLEMMEKGYPVWVREEFEIQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LES6</accession>
    <name>U4LES6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LES6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="144" mass="16349" checksum="D95E9C19CC05EB36" modified="2013-12-11" version="1">MIKPSGAGAQCARTSEPTNHQMMAREVVVAMKRGETEDSQIAYLYAHFSEIFTFLFNLLITSLLFMFLFERLLHLVKSSIVFVFSKSCAIRITQQSVPLKAFLSSVPTLSPSLKLRSPMRARFMNPSDSPCPARLFNPFNPYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LET4</accession>
    <name>U4LET4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LET4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="8695" checksum="D594F80CB4CDAD61" modified="2013-12-11" version="1">MEPSRRKTRSQTAAPLVPAPSPAAKQKAPQPPPDTATQEDEMRKLKARIIELEKRYSVSAAGSGLSNRSSCSSILFSTSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF22</accession>
    <name>U4LF22_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Probable glycosidase crf2 acc. no. Q4WI46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_09086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF22"/>
    <dbReference type="STRING" id="1076935.U4LF22"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTFSEWH"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652229" evidence="4">
        <location>
            <begin position="20"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="14"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="426" mass="46504" checksum="DE3A1D954D34EE5D" modified="2013-12-11" version="1">MQLLQLSLLTSSLISLTNAVGPAKNCGLINKMKCPQGLNPCCSQFGECGAGAFCLGGCDPRYSATQDSCMPAPISRGGSWPFSSRAQITDAHEYLGDASKADWVMMEGGEMTVDDKSSVTLKMGKEKAQTGTVFSSASYIWYGKVKASIKSSRGAGVVTGFMLFGNTRDEIDFEWTGNDLGKVQTNFYFQGVENHTNFFHYPTPEKPNPAYKPFNTFSEWHEYEIDWTPDSIKWKMNGVLIREKKKADTMQSDGLYHYPQTPCRVQFSIWPGGAANAPTGQRDWAGGNIDWVNHPDIKEMGYYYTSIKDVSITPYEPPKGTKIDGKKSYIWMNPAKNWTQEEVVMSDASSILASPISNGQPSSKVWSLVSEEDLKGIETLPGLVGTGRIVLGGSKGKDGVISAYSGAARVVVARLAVVAAVFAVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFC1</accession>
    <name>U4LFC1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Probable succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial acc. no. Q9P727</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFC1"/>
    <dbReference type="STRING" id="1076935.U4LFC1"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTRVIFQ"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000340">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="668" mass="71165" checksum="C570C75EB8990583" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFG4</accession>
    <name>U4LFG4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to High-affinity methionine permease acc. no. P50276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFG4"/>
    <dbReference type="STRING" id="1076935.U4LFG4"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKLKGVA"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="548" mass="59411" checksum="56B169299FE4B741" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFH6</accession>
    <name>U4LFH6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_08980</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFH6"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFQNVMR"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="335"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="433"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="531"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="683" mass="75044" checksum="C1AA15D0BFE389BE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFQ9</accession>
    <name>U4LFQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFQ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10722" checksum="EF8773875B2F8D5C" modified="2013-12-11" version="1">MKEKRQTQRIHHLFFLSVIDAKPFNHQVLIPFQMHRLSLHKTSISTSVPSNVVFVEELSLLRGRDASVMRATAAIPITTSGREVFAWRISMCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFT5</accession>
    <name>U4LFT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFT5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="330" mass="36298" checksum="495CB94498684D71" modified="2013-12-11" version="1">MSTPETPENMLQISPDKNLHLSLTTYHVFTTSSIKSGIPLTLLHHPVDSPETDPSDYLEEIRRSSESQANLIAYLPWQGEPKVPEATEKHATAAAPSTNQNPTQHTKQATQDDQKQSKQDTQSKSFPIYTFQAGTEIPFNGASSLVAASHLFTCYPSLDTIVLKSRVGDVVCSIPRAPRALHITYSPPESKPDHQDPITIQLPHPISSSLQTSIGIPTNDTHPIHAPTLSGDNSQVRLKFSGPPGDREVSFIELSDEEELMKTTPTPATGMEEGVMFWTRVPNCAQEEGGAEVRQVPKIKARCFVKGEEVRGMQPREWRFGGLVKEEQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFX7</accession>
    <name>U4LFX7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Probable phosphoketolase acc. no. O74770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFX7"/>
    <dbReference type="STRING" id="1076935.U4LFX7"/>
    <dbReference type="eggNOG" id="ENOG502QUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GCMDDRE"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003616">
        <property type="entry name" value="PRK05261.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="600"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="802" mass="89066" checksum="50846D5D7B653CE9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFY6</accession>
    <name>U4LFY6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_09206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFY6"/>
    <dbReference type="STRING" id="1076935.U4LFY6"/>
    <dbReference type="eggNOG" id="ENOG502SEZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPMEQNR"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX30803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="188" mass="20823" checksum="FA667593B08A4613" modified="2013-12-11" version="1">MLEQIPGSLPPGKASPATPAPSREQAIVYYDRIKKQLRDLIHSKRHNDKQLSIYEENIYKAETAYLEETPNGNIVKGFDNYIKAAAPRRKTNFNDQDRIFSLSSITYAAKLQAEDSAPVTAASTPTVPDLPRLQTQNAASRTGAPSNNKKNPNRKRKVEDDESASVSEVETPGPKRVRISFSGQNGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG24</accession>
    <name>U4LG24_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Maf-like protein C3G6.03c acc. no. O14141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG24"/>
    <dbReference type="STRING" id="1076935.U4LG24"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RDQRMHK"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="291" mass="31813" checksum="D910B8BF3265CEB8" modified="2013-12-11" version="1">MATWLYNTLFGAAPQTITVGNPSSSVPLLSDTDTRRSEKPSPGSSSVDKRASMRPRPPLSLPALDIIRGKRVILASASPRRAQLLSLLSLNPEIIPSSFAEDLDKGTYTPWEYVLETATQKCMDVYKTQIELTNNGVEEPVLVIAADTVICLSTGEVLEKPKNEGHHLAMLQTLRDVGPHKVYTAVVCMSPSEGATYPGYHMQSSVEETTVVFDKMVTDELLKSYVLTREGADKAGGYAVQGLGSILIEKIEGCYDNVVGLPLRTTLRLIEKVLNGDEEMEKEEGEEDVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHK2</accession>
    <name>U4LHK2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHK2"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="11503" checksum="C2E3C3AFCD1A0736" modified="2013-12-11" version="1">MMSNPASLISLYNTKDHSDLTIKVGSADFFAHHAILKPRTPFFERATKKESGFVESKDGVVMIEDHSTHAVWRFLMYCYTGDYSAESNNIGLGESRFCSWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHR2</accession>
    <name>U4LHR2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935633">
        <property type="protein sequence ID" value="CCX11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHR2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4757" checksum="4BAE44918154A482" modified="2013-12-11" version="1">MRGRPTGLQRLAQRLSSQRQSDCSRFQRQQLHPRPNPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHS0</accession>
    <name>U4LHS0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHS0"/>
    <dbReference type="STRING" id="1076935.U4LHS0"/>
    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="203" mass="24159" checksum="AE93AC45CDF3EF17" modified="2013-12-11" version="1">MGALKYVEELQKKKQSDILRFLLRVRCWEYRSLNVIHRASRPSRPDKARRLGYKAKQGYVIYRIRVRRGNRKKPVAKGATFGKPTNQGVNQLKYQRSHRSTAEERVGRRCANLRVLNSYWVNQDATYKYFEVILVDPQHKAIRRDARINWIVKPVHKHRESRGLTATGKKSRGLNKGHRYNKTTAGRRHTWKRNNTLQLHRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIB1</accession>
    <name>U4LIB1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935561">
        <property type="protein sequence ID" value="CCX31272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIB1"/>
    <dbReference type="OrthoDB" id="10513162at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="17710" checksum="BE392CC8255E553C" modified="2013-12-11" version="1">MPPTPPLVRGSMMTISEDAPLPSPAPRTGPPRGHGTFGYSYTFRDASYPSSPPLGGSRPNSRPESPDKDPWEKEFFIGASASAPISPRHTPPGTPGFGGDLAGDLAALGGGTRGFGFRGSGAEGPNFSWMPKEAPIRGGSAPTSRSTSPSPAQRKTQANHGGERSTFGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ45</accession>
    <name>U4LJ45_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to L-tyrosine decarboxylase acc. no. B8GDM7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ45"/>
    <dbReference type="STRING" id="1076935.U4LJ45"/>
    <dbReference type="eggNOG" id="ENOG502QUUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATWLTHK"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="971" mass="110135" checksum="CFD18437DAA47BA6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJC7</accession>
    <name>U4LJC7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJC7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="231" mass="24845" checksum="79FAC120283914E3" modified="2013-12-11" version="1">MRTSCSSTRSLDSRLTSSPVVLIPIKRRSFSPAEYEDYDEEESKLKPKTSRAAPRTRPSTLIPQEDGLEDQIASSKSRVDKRTASMALMERGRKVSPGVSGPNPKSTFKTASKSVLTRSAAITKPAPKPILTRSTFVHKAVPKDSKASVKTSSKDTLSSATSKTGKATRSHTSSSTGAKVAKATKSASTQSQNQHAQKREKVIKVAALVKPVSTCIRSYTPLPAKVKKTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK61</accession>
    <name>U4LK61_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Guanine nucleotide-binding protein negative regulator 1 acc. no. O59762</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK61"/>
    <dbReference type="STRING" id="1076935.U4LK61"/>
    <dbReference type="eggNOG" id="KOG2919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFECPLA"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="459" mass="50382" checksum="2F468C59E214219E" modified="2013-12-11" version="1">MSNPLTPPPPPSSDSQVLEPPQESAPQATQQWPNIETPLRLVGSTGTTYCGTIVETTDNPYFLHSNQRENNEENNVFKNLQWTPDGTTLLTHSEDNGLRTFILPPNLLKPGERRLKPYNTTFSPSRVYSYLIHPHAALSFPESMLYLLSPRDSLIRLHSLLGPDMISSYRLEDPDTEAHLAPYSLLIPPSSPHTFFAGTSNKISLFDLNYSGSGPFQQIRTTQSKKAPQTTHSMKGLIMAMAMSTDGILAAGTNTRMVGLYDHEGSGSCITTFEVEGKGGGVTGLHWSNCGMYLYVAERRSEVIRVYDVRKTWSVVGELRGRRGNGNQRIGVEVQPDGTVVGGGEDGVVRIWRGVDGEAVGGWRAHEDPVTCAAVHPGGAVVATCSGTRRGRKWEDSSDSEEDEEGERVWDNSLKIWEMPPIVTRGVALEVGGSEARRSQEEREIAMEEAGSEEGEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKJ1</accession>
    <name>U4LKJ1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKJ1"/>
    <dbReference type="STRING" id="1076935.U4LKJ1"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="221" mass="25048" checksum="4F1294E6F9EB088B" modified="2013-12-11" version="1">MFKRAIFSQSRQIAAAARIPAARVVVPTTANTPARRWYSEEAKKEEATEKKEGTPKVSEEIEECNKQLEEKTKEAKDYKDKFTRAVADFRNLQDRTEREKKAAKDFAIQKFAKDLVESVDNFERALNAVPEIEKSANKELVDFYAGVKMTEEIFLSTLKKHGLEKINPMGEPFDPNKHEATFQVPMPDKEPNTVFHVQQTGFLLNGRTIRAAKVGVTSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLA2</accession>
    <name>U4LLA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized FCP1 homology domain-containing protein C1271.03c acc. no. O94336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLA2"/>
    <dbReference type="STRING" id="1076935.U4LLA2"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="206"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="697" mass="78775" checksum="CA3727B7430FA950" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLI0</accession>
    <name>U4LLI0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTF/NF-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_14009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLI0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="2">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="291" mass="33716" checksum="261A14EDE00817DA" modified="2013-12-11" version="1">MAALGSVLCSRSCVFLTDSIQISPPYTGPEMTQLIYDVLLWIDTHWSELGPISSDPPPRNFEGLISTFKDFRKHITSTDVDVDTRAQFTVILDQIERVNLLFNHYWDTTFIISTPLDRIKQYRDDFKQGVLGEMIQGRDLSNPLRPATLKYIDTVLVWIEDNIKEYYPQKTIPTDDDVMYLLFITPCSDGRGITEAMKILMQIVRIKAFVEYYQQRTPAEPIPLKYLHQYHTEEEKKSREENRQKAIDKMLAVNKRRPGNAGINEPNYTEPYAKPTDEPPNASVQFTTINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLU8</accession>
    <name>U4LLU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protein MNN4 acc. no. P36044</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32572.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLU8"/>
    <dbReference type="STRING" id="1076935.U4LLU8"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ILGHYDT"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32572.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="26482" checksum="978AD8D66AD33266" modified="2014-03-19" version="2">MVRAWLQMTSNNGIETWIAHGTLLGWWWNAKMLPWDWDLDVQMHADTLTDLGKRFNLTSHKYTSADGTVEREYMLDVNPWIWERVRGDGQNIIDARWIDIRNGLFIDITGIAETDANHPGVLNCKNYHRYKTEDIWPLRDTIFEGVPAKIPYNFDPILVKEYGTKALVVTEYEGHRWNVASKAWERAPDVPSGHLGALRTPRVPEKYSTVETGGVLYNLYRLIHWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLX3</accession>
    <name>U4LLX3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLX3"/>
    <dbReference type="OrthoDB" id="10392548at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="470" mass="50959" checksum="18C742D6E1399F27" modified="2013-12-11" version="1">MTTPITIAKRTPNTAAAASPGRSVSANYVSANRSTDYESSSPKLRNSSIGVPGRSPNKWRPHNTSLGSDSGLKTRDNVGADHVTSWKTDLPTRMRKPPPKFAADNGTTTNSLSPKKATSAVPPLPDQRKFVFPSRPVPTTESQIPVLARSTIRLVADEDESPPQSSNPTVEDTPSHNEVESDPLLINPKLRALTHENMSVTQNPEYLAPHSMLPAVRRVQSNEPITAVVAETASSIVTPCSSSASSIVDKSLQNYLAGADQGTTRRRRGPVKRITHQRTDSMISVASVSSMSSSIHGSNLPHWDQFDTLPREQDAYTSFPKYQSNTTRSSGIMRMGAKIIGEDSKNGLTGIRGFFSRVWTRKGSNDSQYRPSSLQRSSSVVDVPEQAIHARSSVEMGTRPIQSTDSDSQTGEEKTKPMLIPGTLKQDVIDYDQQTPTQQALQSPAISEAQCPLTTGGESLTPKTTWIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLZ6</accession>
    <name>U4LLZ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLZ6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6575" checksum="9923BBD43FE8039A" modified="2013-12-11" version="1">MSSYQVHNGCCQFLADRGCKKYCFQHIIGLMRVLRINIMIGFRAISVINFVLTEYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMJ1</accession>
    <name>U4LMJ1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMJ1"/>
    <dbReference type="STRING" id="1076935.U4LMJ1"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KMVYDEA"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="211" mass="24060" checksum="6D793FDB3402A4A7" modified="2013-12-11" version="1">MPSAIETPEDKPTKLVVTVDKPIPLEFDMGNLVCFDTNPLDPETYKTDREACLNAVIREGAQALINQVLTALTLKSTADGVFAELPEPVTPLPREKAIPKPREPTKWELFAKKKGITDKPRDGKLVYDEEKQEWVPKWGYKGKNKEVENQWLVEIDDTKKTEDGDEVNPRKLSRDERKRNIKLNERQQKKNAQRSDAVLGAKKGGVEKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN38</accession>
    <name>U4LN38_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_14027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN38"/>
    <dbReference type="STRING" id="1076935.U4LN38"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="261" mass="29503" checksum="E63C7DD62D03E3D9" modified="2013-12-11" version="1">MPQNEYIERWTKQHGRRLDHEERTRKKAAREGHKQSKDAQKLHGLRAKLYAKKRHNEKIQLRKTLKAHEQKSIKSSAPSEPSSQPLPAYLLDREQPNTAKALSTAIKQKRAEKAAKFSVPLPKVKGIAEDEMFKVVKTGAKTKKKGWKRVITKPTFVGPDFTRRPVKYERFIRPMGLRYKKANVTHPELGVTVQIPILSVKKNPQSPMYTALGVLTKGTIIEVNVSELGMVTAGGKVVWGRWAQITNNCENDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP22</accession>
    <name>U4LP22_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_02138</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP22"/>
    <dbReference type="STRING" id="1076935.U4LP22"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="55947" checksum="E8B712FA2CA7B6F5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPA2</accession>
    <name>U4LPA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPA2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="10479" checksum="46AA610364BB0796" modified="2013-12-11" version="1">MPTTAKIETMPASQYDKTSGATWLFRVISSTMQISILGVLIWIGATLKSIEMGFGLEEGYGRAGVRVFSAPVMAVNITNTPTMAVVGTPAVSVIATKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPH7</accession>
    <name>U4LPH7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPH7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="31" mass="3518" checksum="78F7A65B01E1FB50" modified="2013-12-11" version="1">MNSEIINSSISSPNSLGTCMLRKIWYCQVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQB5</accession>
    <name>U4LQB5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936658">
        <property type="protein sequence ID" value="CCX17471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQB5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="21" mass="2569" checksum="73A1279EF61CAD80" modified="2013-12-11" version="1">MQINRRFPQQERNFEAFAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQD7</accession>
    <name>U4LQD7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Retrograde regulation protein 2 acc. no. P32608</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQD7"/>
    <dbReference type="STRING" id="1076935.U4LQD7"/>
    <dbReference type="eggNOG" id="ENOG502QRXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWGYMLM"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="53"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="359"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="564" mass="61490" checksum="8EEEA742A7992BCE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQJ8</accession>
    <name>U4LQJ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Anaphase-promoting complex subunit 13 acc. no. O74358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_05652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQJ8"/>
    <dbReference type="eggNOG" id="ENOG502S7KP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRPINPE"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX29581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11408" checksum="3A2D3700C0D06E65" modified="2013-12-11" version="1">MSKDSARTHVHLNSGRFADLFEDFCRDRIPDDDIYVPPHHQPINPEDEDDVIPDQHAAFGITQAQQKKREPAWKDLGLNDLMREGMSSGGSDEKPKKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR11</accession>
    <name>U4LR11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
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        <source>
            <dbReference type="EMBL" id="CCX34626.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="EMBL" id="CCX34104.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="EMBL" id="CCX32020.1"/>
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</entry>
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            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="EMBL" id="CCX32300.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <source>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="256" mass="28904" checksum="611ED99894E27559" modified="2013-12-11" version="1">MEYLNVHDESFSRPQSSAANSWRGSYASSSGESYTEIQLLPISSGRSDDHRSSEDSHGESHSSSSDTGTEHHHIEPIVKDKERVPEGEAQDHEEHHHECECGHDHDGDDEHDNDHDHDHIDKEDELQEVPTGFFGKIEKFWCNNVTIIVPGATARDHLALERTYLSYHRTSLVLSLISVIIAQLQVLQKSPAHDTRFGFHVLGKPLAVTLVLCSMLTSLIGVIRWWHWQQTLLRGKAIFLAVGIKKTIEDVPELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSW1</accession>
    <name>U4LSW1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Long-chain-fatty-acid--CoA ligase 1 acc. no. O60135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936618">
        <property type="protein sequence ID" value="CCX34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSW1"/>
    <dbReference type="STRING" id="1076935.U4LSW1"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="234"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="655" mass="74103" checksum="5CDB84CDAC1CD2FD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSY5</accession>
    <name>U4LSY5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_04281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSY5"/>
    <dbReference type="STRING" id="1076935.U4LSY5"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTPLTRD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651741" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="967" mass="107842" checksum="5F620EAF759E96C0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT02</accession>
    <name>U4LT02_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to similar to class I/II aminotransferase [Botryotinia fuckeliana] acc. no. CCD53504</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT02"/>
    <dbReference type="STRING" id="1076935.U4LT02"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="102"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="493" mass="55540" checksum="1944D940A3428197" modified="2013-12-11" version="1">MDPRNILSPQPRSGVPGITMTDDNNEQHSFQELLQSLQNAMVAATAIERSSTPHLRYREAHAAKPVHKHPGLDPSKASTGVVWTTERAYEAGFLDCPEEWGNLGQGAPEVEDTIPHAFHKPTTLDISVNSREYGPVAGIMPLRKAVADLYNAHYREGKESQYTWENVAIVPGGRAGLIRIAAVLNNAYLSFFIPDYTAYNEMLGLFKNFSALPTLLDEEDGYELHPEKIKEEIKRGVQVILTSNPRNPTGHTVKDEALKELMDVCRGRSTLIMDEFYAGYNYTSDCDGTSVSCARYVEDVNNDDVLIIDGLTKRFRLPGWRIAWVVGPKEFIKAIGSCGSYLDGGSNVPFQEAAIPLLEPNFVRAEMRALQLHFRDKRDYVIRRLSDMGFKFRSIPDSTFYIWLDLSHLPPKIQNGLGFFEECLKEKVIVVPGIFFDLNPQSRRDLFDSPCHHYCRLSYGPKWDTLKKGINGIERVLQKHDALPEGYTGEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT25</accession>
    <name>U4LT25_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT25"/>
    <dbReference type="STRING" id="1076935.U4LT25"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="15558" checksum="308FCAD528F3CF83" modified="2013-12-11" version="1">MSKQIPGILSFIKEVSKSNTKMQYSTMNALQGVRKQLGDVEVNELLEWISTIDPQTRHRDISRKRRENTGDWFLRTEQFLKWRDYSQGSDESFENTILGVYGIPGAGKSVIFSFIVDHIQTAFESENEYCITWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTB4</accession>
    <name>U4LTB4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Ankyrin-1 acc. no. P16157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTB4"/>
    <dbReference type="STRING" id="1076935.U4LTB4"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WISSEDY"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF52">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="62"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="306"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="630"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="706"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="778"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="886" mass="99894" checksum="144402344847F078" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTD3</accession>
    <name>U4LTD3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTD3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8629" checksum="C4EB4F12F5A45A78" modified="2013-12-11" version="1">MLNEPKTEAGDLEPEARDSPPMRSRFRAPRASRTVDSALNNGHEVHAAPSKDRRLHSYTVSHVWNFGAWGLEFGVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTE7</accession>
    <name>U4LTE7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_13636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LTE7"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEDIAWD"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="68"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="271"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="609"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="681"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="761"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1529"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="615"/>
            <end position="623"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1669" mass="188445" checksum="7446CF2D88287BC2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUL3</accession>
    <name>U4LUL3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Exocyst complex component sec6 acc. no. O74846</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUL3"/>
    <dbReference type="STRING" id="1076935.U4LUL3"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="669" mass="76776" checksum="678D9F0FC1EEEC55" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUP2</accession>
    <name>U4LUP2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial acc. no. Q12644</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUP2"/>
    <dbReference type="STRING" id="1076935.U4LUP2"/>
    <dbReference type="eggNOG" id="KOG3256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QFFRAPY"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="214" mass="24448" checksum="145C56078A034C7B" modified="2013-12-11" version="1">MASIRTASVFGARTLARPAVVPRAIVPTIRNATTASSVRLPRLRRPETWEEGESTLDRAGKYFLMTEMMRGMYVVMEQFFRAPYTIMYPFEKGPISPRFRGEHALRRYPTGEERCIACKLCEAVCPAMAITIEAEEREDGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNQEYATETREELLYNKEKLLSNGDKWEPELAACIQADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV24</accession>
    <name>U4LV24_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="HF936394">
        <property type="protein sequence ID" value="CCX34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV24"/>
    <dbReference type="STRING" id="1076935.U4LV24"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="354" mass="38177" checksum="E67112571B8029B9" modified="2013-12-11" version="1">MSKMSAADTIADTPAAGAQNTKSQQQRTSAPPAPSASPAATTEKKDVHQADPKKPRKPRPPMSADVKISKALSSTLRHNAAKEGLTLREDGYARVDDLLAMNKYKSHRLTFPQLKEIVDSNDKQRYSMTEEAGVWYIRANQGHSISVAVEMEPLPHPGEIVHGTYYAFLEPIITSGGLKRGTRVHIHLAPAAKVLGAKGDEAETHEVAEEGVQGKGAHQDDTVISGMRKDAEIVFIIDGDAAAASGMRFFKSANGVILTEGNEEGVLPMGFVKRVEDRKRGLGTVWQQGVGMKVEIREEWKKVPLGKGGGEGGDGVGAEEVRGEGRGAGGIEVGRGQRVLWRWGRFKEERDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX89</accession>
    <name>U4LX89_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Start control protein cdc10 acc. no. P01129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936511">
        <property type="protein sequence ID" value="CCX34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX89"/>
    <dbReference type="STRING" id="1076935.U4LX89"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="64"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="708"/>
        </location>
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        <location>
            <begin position="749"/>
            <end position="776"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="827" mass="89222" checksum="1ACC15F877DEB363" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXF7</accession>
    <name>U4LXF7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXF7"/>
    <dbReference type="STRING" id="1076935.U4LXF7"/>
    <dbReference type="eggNOG" id="ENOG502RUYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="464" mass="52672" checksum="A71E16BE15A341F1" modified="2013-12-11" version="1">MQPSSEAHKDQQQLSDEEEKAIVRFCQHVDDLGHPLNLGTLKAFAIAIQPPSKCREVRKHWITWFPDRHPELEFRCSQCLDRQRANANDPVLIKDYFQKLRKLIRGHSLHPENIYNMDEKGFLLGQAPKVKVMCRRARKNPKFTQDGNSEMEKDAIFMFSPKGWTDNKLRLEYIQHFDRQTKAINEIDEWLRRGGNIDKKGQFYDHLIATMLCQCARETALTPTNICKAFETTGIWPFNPTREDLGRSTPNTHAYQGCQQVVEIIDGHGEGRFCSCTANNGLIDQLGRVVIGALVEKEIYAKDASDLRVSKKDVSVKAVKNHRHLSKASVMTEADVQCLGDEKLQQELEKADTDKKCLARTSVTTAKGKTTINATKQIGKQVTWVDQALSIVEDDWIKNAQDITTYMEEEGADSGHEEDPFIDIDDVLGSRGIISCGNMAEYEGKRVEVVTRSGRRAQSVSYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTR3</accession>
    <name>U4KTR3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_01768</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="HF935197">
        <property type="protein sequence ID" value="CCX04278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTR3"/>
    <dbReference type="STRING" id="1076935.U4KTR3"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX04278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="686" mass="76978" checksum="2844C24FF7F1A40E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUF2</accession>
    <name>U4KUF2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUF2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7354" checksum="49E58B9DB3A5FCD0" modified="2013-12-11" version="1">MKRCSWTMDGTAGNRRSVACSVSPIPPVIEDEVEMELMMDSAAGKMEASRIRTMKRSRWTAGYAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVB8</accession>
    <name>U4KVB8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_05040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935254">
        <property type="protein sequence ID" value="CCX05453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVB8"/>
    <dbReference type="STRING" id="1076935.U4KVB8"/>
    <dbReference type="eggNOG" id="KOG1040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX05453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="325" mass="36031" checksum="0F860E7E7BFE4492" modified="2013-12-11" version="1">MTTMNTHGNHGHGNHMQNMNAMNAMNMQSMQNMHYGPYGQQQQQQQQQQSSSFSTSSASGPSGQSGSQSNAINSNNSPAPSTNYADLILNPPSSADANLTSKFAFNDFLRKEYRFGLDPSRKTCPLFVQGHCPMGNSCPDKHAVSSTFNNLVCKHWLRSLCKKGEGCEFLHEYNLRKMPECNFFVRNGYCSNGEECLYLHVDPDSKIPRCPHYENGFCPLGPTCSKKHVRKAICKYFLAGFCPDGRQACKEGAHPKWTAPNMLPMPTVKRPREEGEWGQGGFQGGFQGGQQGQGFGQGQQSGFGQQGGLQGQPPRKRFWGRGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVS3</accession>
    <name>U4KVS3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Cutinase transcription factor 1 alpha acc. no. P52958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVS3"/>
    <dbReference type="eggNOG" id="ENOG502QV53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHTLVIC"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="818" mass="91723" checksum="A0A8DD29778D8BEF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVV9</accession>
    <name>U4KVV9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVV9"/>
    <dbReference type="OrthoDB" id="10534367at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651678" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11024" checksum="098B3485181FE695" modified="2013-12-11" version="1">MYTSIISFAFLVTASLTCDLNPALAAAHYTSYPLYAQSCLSRAHALHNCDTHSKCADARFIQDACSCIKTACSDDMQQRVRVMVTGACEVFDANYQLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWR4</accession>
    <name>U4KWR4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935287">
        <property type="protein sequence ID" value="CCX06377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWR4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17781" checksum="0008F9BECC9329A4" modified="2013-12-11" version="1">MSVPNPSNAAPTIKSEPPPQELAEKAEQVPEATATTESDKILRDKCGRFMTGIRPLGNTSTSRKRGYVRTGFKLPACRKDGYPNAHRINRDDSQARCMKCRYLQQRYKAQPDGIEAHMFNKDIIGPKGRLRRSIYRCSYCTIGGQPVPLCREFCFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWT8</accession>
    <name>U4KWT8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_05703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWT8"/>
    <dbReference type="STRING" id="1076935.U4KWT8"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNYKFTW"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="136"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX06116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="457" mass="49537" checksum="ED42ECC04D26E73F" modified="2013-12-11" version="1">MAAVVEAVSNLVSPSQSVLLLGSGFVAKPCLDYLSEKGIAVTVACRTQVSAEKLSEGVKHTTPISLDVSNEAALEAEVAKHDLVISLIPYTHHATVIKAAIKAKKHVVTTSYVSPAMEALDAEAKAAGITVLNEIGLDPGIDHLYAVKLFDEVHAAGGKVVSFLSYCGGLPAPENSGNPLGYKFSWSSRGVLLALRNSAKYWKDGKIEEIAGPELMAAAKPYHIYPGYAFVAYPNRDSTIYKERYGIPEAQTIIRGTLRYAGFPEFIHVLVDMNFLSDEPSADFAQSLPWKTALAKLLGSSSEKEEDLIEIISSKTKFASEEDKNRIIAGLRWLGLFSDEKNTPRGNPLDTLCATLEQKMQYEEGERDMVMLQHRFEIENKDGSKETRTSTLVDYGVPGGYTSMAKLVGVPCAVATKLVLDGVITDKGVIAPMNAKINNPLIEELKALGIECKEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXK6</accession>
    <name>U4KXK6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935197">
        <property type="protein sequence ID" value="CCX04279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXK6"/>
    <dbReference type="OMA" id="WKCCGRE"/>
    <dbReference type="OrthoDB" id="5422415at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="936"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1021" mass="108248" checksum="3327A1003F88FBF4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXV0</accession>
    <name>U4KXV0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Sad1-interacting factor 2 acc. no. O74446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_05937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935286">
        <property type="protein sequence ID" value="CCX06350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXV0"/>
    <dbReference type="STRING" id="1076935.U4KXV0"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHRHGEY"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="5">
        <location>
            <begin position="251"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="470" mass="52489" checksum="4562B612BE9C6283" modified="2013-12-11" version="1">MAANNQETQPLLPTTTTPSPVPSTPPRQASGTGGLHDSTAPGPRLALRNRALGARGTPPPVQQAKIGPQRTSKVSQKLKILPSPEDQDEESGRDVYSQVTRIKDTTARRDAERLGKAERTRLPRVTAYATANSYNLDGLMKFLKGRTATRGTKPRKFDECIFSPFSYTHKQATEDLLGDLHGEVNKNKTTGNGNAAPTSAALPAALNDEEAQHIQDAEDQDLDQDNGDGDDTRSLMNFVDQQHRAINNGDVFLFQYGVVVIWGMSLEDEAKFLRDIAKFENEKLADDDVQVENFNFYVTSSYQPRIYNDFITLRDNRNYMIKLSISHAIAQSVKISLFEDLMNTAIDETKMIPDDIAQTGKVGISRKEVMKHIGELFILRININLQGSVLDSPELMWKPVYQAARSYLEINQRLELLNQRLEVIKDLLQMLKEQMTHTQGEHLEWIVIILIAAEIVVAVVNVCVDLMASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXY6</accession>
    <name>U4KXY6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_02007</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="HF935202">
        <property type="protein sequence ID" value="CCX04404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXY6"/>
    <dbReference type="STRING" id="1076935.U4KXY6"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHVNGKW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="131"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="471"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="769"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX04404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="812" mass="90367" checksum="FC9E969BF4607386" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY48</accession>
    <name>U4KY48_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935320">
        <property type="protein sequence ID" value="CCX06886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY48"/>
    <dbReference type="STRING" id="1076935.U4KY48"/>
    <dbReference type="eggNOG" id="ENOG502S3DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLLDHWT"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="360" mass="40472" checksum="9D8B1B807D6F4FE3" modified="2013-12-11" version="1">MATCFPHLSRLFYRPKPPPAPSPPQGLRVETYTYSTPAPGVELKVDCHLPLNDPGWPRPAVLYFHGGNLFFGDRSFYLRGLCEDCTSKGWIFLAYDYRKLVPFTGHDIIKDLNTLFSHYHTVLAPKHNLSATNVFVAGYSSGGYVAQLAAAHWEPKPLGMFLVASQGGKMLSQKYYAEKEEELGPIPEILKGYLDGGGKEMRKVGSLLQHGNDLQEFDNRLALSVEVHKRGLQLDLLTGIPDLSGKLRAVENNQEELEKLIPDEAKCLFPELLIDETFPPAFIVHGDKDTTVLLEESKSLVENLEKRQVMAKLVTVEGAAHQTMLFDAVYKDYMMEVIPWIQERCVADEGEEDEMEDLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY85</accession>
    <name>U4KY85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to UPF0743 protein C215.06c acc. no. O94311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY85"/>
    <dbReference type="STRING" id="1076935.U4KY85"/>
    <dbReference type="eggNOG" id="KOG2186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTHPISE"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX06931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="34552" checksum="9DB1A4A3F542DBDA" modified="2013-12-11" version="1">MVSFNCEACNDVIKKPKLDAHRGRCRNAVFSCIDCSTTFYGTDYRNHTSCISEEQKYQGALYREPKKKGQQQQKQQPKAAEKPVEKVVEEAKDIEMTEAPVEEKKEEVKEEVKEEKKEKKEKKEKNEKKEKKEKAKKDEKPKKEKKEKKDEKKEEETKEEAKEESKEEETPAEEEKEEEAKKEDKKEKAKKEKAEKKDKKRKADDAEAPAAEAKKTRTDSRDAVEVFFENFKAGRPVTIQKAIERTKKDIGDEFDAEALLNELKVKREKDGSLVLYKDEKKVKNAKKGGKKEEAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY97</accession>
    <name>U4KY97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY97"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="18399" checksum="F843DA142E0E9259" modified="2013-12-11" version="1">MRATSLINASTNLKEDDRQEDNKGAGKEFQVNAKGKIKGKIKGKIKGEIKGEIKADIKENVKSDIKGDDKEKVRERQETLYDQSPVQAGHGIEPLQLTGHGRPVGSFIGTRYTDYLQANMYGLTQRMPYHHFQRDGIYIAIPGHCIPINNTITTTSEFLITNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYA8</accession>
    <name>U4KYA8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935341">
        <property type="protein sequence ID" value="CCX07202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYA8"/>
    <dbReference type="OrthoDB" id="10549139at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21102" checksum="FC7E760425CAFBB9" modified="2013-12-11" version="1">MPLRKKKPLSLCGYFSPELRHTPKSDQLPQAQATSVTGIDQVTNKIAHSDQLSKNSILKKTPTSHPHRFDLFNLGCRLICKPKSDNRPEAPPSTTIAKDEAYQKDTDTTKVTKRVTFGVPSQGPPSTTMAKDKAGGEDRGTRKVARPKVTFDVIYEEDEDNERVRAPRRRETHPNIRELNRGQATSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYD3</accession>
    <name>U4KYD3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C106.07c acc. no. Q9URV4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935345">
        <property type="protein sequence ID" value="CCX07237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYD3"/>
    <dbReference type="eggNOG" id="KOG4526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YHSSIWT"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="1">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19384" checksum="3CCED19F570437F9" modified="2013-12-11" version="1">MSSIPRLFFRANLPRRPVTPRFFSTAAPPPKPSLSQRMKQLSKEYGYSAVAVYLGLSALDFPFCFLAVRMIGTEKIAEYEHTIVEGARSLYHAAGLPGWEKKQVEEEEKNHKAATIWTELALAYAIHKSLIFIRVPITAAVTPKVVKTLRKWGWDIGKKGGLKNAVKGKKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYD8</accession>
    <name>U4KYD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935296">
        <property type="protein sequence ID" value="CCX06560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYD8"/>
    <dbReference type="eggNOG" id="ENOG502SZBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VPSRMVH"/>
    <dbReference type="OrthoDB" id="5387493at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32219" checksum="2E9B5268B240FB26" modified="2013-12-11" version="1">MASLTPLRFFLRPTTFAAPTRCTRTYANKAKGLRKPKTFVPPAKGTKPAVKPSFTVKPATPAPGKVVPAAPVAPVAQAAKVAPATLQDALAQAGFKTVQEKLALVGKQQLLFAGHPKRFIWTVYGIAGCFAAFGANFYRENILNAPKDLPDWVKKMVYVGCAFVAVVAGVAAWFPTRIVEKIYYIPAKSGFDVLLYRRPAFPMLPWKKIQVPAKSVMLETEFHPVVEVIKAEPHLSLMEKASKFFQEGVATSNFRSIYVNGKKFHLHKQGWVWERRGLDIIFKKHGSFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYT7</accession>
    <name>U4KYT7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935318">
        <property type="protein sequence ID" value="CCX06835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYT7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650970" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="14389" checksum="4EBBC70AE7DA796C" modified="2013-12-11" version="1">MQFLPLILTFLPAVAPGAAVVHPRPANRQDLAAENNSFIYARLCPLRNLGGDCQEFITDGDGSCDSIVGTTMDNKAVSVEVGGEACCTFYDDPDCKSSSLFTLTDGRIDLLNNEYKNRISSFQCRFGTGCPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYV7</accession>
    <name>U4KYV7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Cell division control protein 25 acc. no. P04821</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYV7"/>
    <dbReference type="STRING" id="1076935.U4KYV7"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EEVWERD"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="752"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="929"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1228" mass="135471" checksum="AF709CE56DF4C162" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYX2</accession>
    <name>U4KYX2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_06467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYX2"/>
    <dbReference type="STRING" id="1076935.U4KYX2"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="243"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX06880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="715" mass="79457" checksum="10C1FB73BDC28A2D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZD5</accession>
    <name>U4KZD5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZD5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="14098" checksum="1066659C77349E81" modified="2013-12-11" version="1">MNDDIIKHVGTGHGKMSKLHALARETSGGGEWVIGRAVMNVAVLHRRTEELKRCTSRRGRKGVDYCMLADIGAVVNWAVAHDNAQPLPELPTAEELRGLGLKVIGGFFLENLKRVRSGKWPCSCRPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZK2</accession>
    <name>U4KZK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ATPase family AAA domain-containing protein 3B acc. no. Q5T9A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZK2"/>
    <dbReference type="STRING" id="1076935.U4KZK2"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FDWENKY"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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            <begin position="811"/>
            <end position="936"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
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            <begin position="65"/>
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        </location>
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            <begin position="155"/>
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        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
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            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118291" checksum="97A77E93D83228C3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0G2</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX08578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9699" checksum="49D064B5F8E84EBC" modified="2013-12-11" version="1">MVRFSSTWIPSAWAIRVIYEYTRQIFQMRMEFETVAKLPNKELGLMTVVMQARRIAFPNIELSSLITVSALTRLTGCMRWLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0T6</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
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            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="216" mass="24671" checksum="52942685B4A68E85" modified="2013-12-11" version="1">MIDRHYLWPHGWGKQDVFFCRFAVDSPGETMPVGSSSIDFSRPLIRSKYDFPGKTSKITTTLNSHSPLASQVSRHLFSLGIVVLELALGKTVEDLYPNASWIMDFGNITDRNIEDLLESVKNKVNFHEEKAIISCMGLCPRLRIKSIIRNDVLPELYRTSTEMSHAPDQLEDSAKSYKVLHISLLHQYLFYLCLVEGVIKAILYFSTYLKTITETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L197</accession>
    <name>U4L197_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Uncharacterized protein C17D11.03c acc. no. O74758</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PCON_07805</name>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="224" mass="24478" checksum="6C9A2326941E1015" modified="2013-12-11" version="1">MVPILATPTFLTSLRSIPHLPAHSWYYLASVAFALLNRPDEIPHIYAYATPNYDSVTVLNHTREALLKASAIGGLPSTINALNALKTVVAEELLDQPTLSHRQEGALNLEEGDRLWDSIYGKVGPRVMRGMKRSYNDLGIVARMLYAGVLADEGVLGKRETGYVLVTGLVTGGDAWTAQRKGHRRGCVNNGATWEEVEAVETLADKVVEEVRNSLGKEIVGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1E0</accession>
    <name>U4L1E0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_08824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935446">
        <property type="protein sequence ID" value="CCX09231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1E0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="9839" checksum="0E8B8295440A3D76" modified="2013-12-11" version="1">MTNQEQLSSNAVVNATRTIAATTNAITTNAITTITVSTQVRPLPPNPTMFYSGKAITPEERRREVGRVLEMARLAFDTLRKTICDNDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2A6</accession>
    <name>U4L2A6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2A6"/>
    <dbReference type="OrthoDB" id="5461422at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27359" checksum="F8B6EB44EBB4227C" modified="2013-12-11" version="1">MPSAHPAFFPEAFKSQPLLGLDSGTASVRSVASSKYSLHDLDYDPYAENAITPDPFPSAYEFDFARNARSREFEGGSQSPLFSVSSVSLDDGCGALQPPLSNVEEQENPTPPRDHLPTDREEIRKLAMEGRRRTLVRFGEDPDKPLAVPHQVIHSRIDLPSHLNKHKMQRSQSSNTQFGIRRRIADTLEHRNTCNVPTQAAGSFSEEAPASATTPSTETSTLGLLRRGTKRVKRIFKFSKPTNGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2G4</accession>
    <name>U4L2G4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2G4"/>
    <dbReference type="STRING" id="1076935.U4L2G4"/>
    <dbReference type="OMA" id="MKFMRRA"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="260" mass="28597" checksum="18ED22ACCE09E8CD" modified="2013-12-11" version="1">MSQKPAPGAQPKNMSNRLLTMKFMQRAVHSNPGTSKAEASKIAAAAAEETARRTAALHQRPRPAAGSAAIDNDEETEWVLSYVRPVVPEQKYVDNVGYSEMFASDGEDCDSDSDQEEEAGGNATKKEGGRMVFGNFSKKNLEDDKKKSNKGDGEFDSDEELSSDEEEGEERERKPVIKQVSLRGLTSISNSGNAAGLAQMKCHKCNEKGHKASSCTKDVECYNCGKRGHMAGDCEEKRRGKRKEVEDRRDSMPKRGRPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2I8</accession>
    <name>U4L2I8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative uncharacterized oxidoreductase C513.07 acc. no. Q9UT59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2I8"/>
    <dbReference type="STRING" id="1076935.U4L2I8"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEKMQLW"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX10109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="442" mass="48007" checksum="F8974B0D377DEC15" modified="2013-12-11" version="1">METITKAVHDAVSAITGQDSNAQLVKKGDWVLLTGASGFVAAHCLTALLDAGYKVKCSVRSQEKADEIRKRRASHADKLDFVIVKDIVEPGAHDEAVKGVTAVVHTASPFTLDDKEDNRKYLLDPAIKGTVGVLESIVAHNPSIKRVVVTSSFAAMIDLSKGLRPGYTYSEADWNPITYDEAVKVKNGAAAYCASKKLAEKAAWDFVEERKPNFTVATICPPMVYGPLEHSARLDALNTSTADVYRLINGSCKTVPETSFYAWVDVRDVGVAHAAALNAPSDRYFITAGNFTYTQMCEIIARHFPQLVNSGMTPNPAGAPPPPEHYRVDNSRSRRVLGMSYRTLESCMIDLVNSLLKLKATEEGTHYEAAPVSVTDVRTGDEHRSHALPGTGLTGMGSAPKEWKETENLCDCKEGECKAGESSRKKCQGHMEGHSAPIVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Z5</accession>
    <name>U4L2Z5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2Z5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="238" mass="26101" checksum="6E472CEB99B0E160" modified="2013-12-11" version="1">MDYVIEYVGIGIGKLSKLYGLAKETSGEGEWLIAWLAMNAAVVQRRTEELKENLKSRKWMGRPIEYCPIADIYMTREGVEDHRAHPPEEMFPSDGELTKLDLKLIRSVVVPHHFAGDPEASPIDPNASPAAADTPSGPSAADNVQPPPSVGIVSPPAATDIPIPSGPPQEEDIVLPLRKTARRSPPLSPQLKWRRKRPRPDHRSVRPQRGCVPSGGRSSGNEQLPREYWGDAGALDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3K0</accession>
    <name>U4L3K0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3K0"/>
    <dbReference type="STRING" id="1076935.U4L3K0"/>
    <dbReference type="eggNOG" id="ENOG502RYQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TDITFSY"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="505" mass="55787" checksum="5047FDC0319F2A76" modified="2013-12-11" version="1">MVVLMNSHTFVDASSRVGGRVRSEDYELHIRQGPERARVAGVKEKDRKPVDPPPIIQLKIRDDSDPAHATHDQPSLIPPHQALAGTLVSSLHRLKDIDNSDGGFFVFGDLSVKIEGEFRLKFSLFEMLKNEVIHIKSITSEPFTVYAAKNFPGMSESTFLSRSFGDQGVRLRIRKEPRTLLKRPQPRPEDYPRPYMQLAPDPRMPQYPPQSGGYLPHPSHDYGPQYPENGKRQRTDSIVSPRNSIDARAPEHHQYIPRAGYEQHPPPPPPQQYQQYQPSSQPPYQYGHYQSAPPPPQPSYSAHPGHSAPPPPPPAHSSIPDYGQYRPPQNTQPPHHHSAAPSPYSPRPQQYPQQRSPLPPTQPPQPPSQYNRYAPPPPQTHQLPHGSNHPGPPVPRLNSPIHSNPARGPPLPVSLRPPHAPSPLGVSGPPGSSSISGMPPPPLDPPQSGSIFNLPPLQLPPMNSGTQGMHRGPHNTMPPMLTQPSKYGPPTSFDSAAQQQQQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3R6</accession>
    <name>U4L3R6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="HF935524">
        <property type="protein sequence ID" value="CCX10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3R6"/>
    <dbReference type="STRING" id="1076935.U4L3R6"/>
    <dbReference type="eggNOG" id="ENOG502R701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNDMIGN"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005147618" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="124"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="49690" checksum="D2F07DE72D0F068F" modified="2013-12-11" version="1">MKFLATILLLVPAIAALEFPQCPSPSWPTGPGSEIRAPGVPRDMARILSGISDKRIEAIIKKLTTFHTRHTLSRQDSPTIGIGAARDWIKSEYDSFGGNLQVSIQTYLQPIQAPRIDRPVNISNIVAVLPGYDSNRVYVISGHYDTRASDVMNPDIEQHGANDDASGVAAVMEVARVLAKQKFPATLIFAAVAGEEQGLYGSNHLAQTLKAAGIDVQGMFTSDIVGSSTADDGVKDPFSVRLFAQGIPLFQSSAVQAAYAGVGGENDSPARQLARYAASVASNIATGMKVRIVYRLDRYLRGGDHRPFLIAGYPAARFTEPNENYAHQHQDIRVENGKQYGDLAEFCDFQFIQRVSKVNAATLWNLASAPGTPKNVTIDTIALGNDSKMMWIAAKDDNLKGYEIVWRPTTAPDWTNEIWVGLVNEATVDLSKDNVVFGVRAVGKNGYKSPVAFPLPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3W3</accession>
    <name>U4L3W3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Vacuolar protein-sorting-associated protein 24 acc. no. P36095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3W3"/>
    <dbReference type="STRING" id="1076935.U4L3W3"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KILWEVT"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="214" mass="24137" checksum="96508C78532289AB" modified="2013-12-11" version="1">MESIKSIFWKPDPAAQLRKCNALIRKNTRELDRHISTLRTLETKNRNLIIASSKSRHNTPAQTRLLAVELIRIRKQSTRLATSRAQLQSVMMQVSEAFSVRKIEGSIKASTSVMKDVNSLVKLPELTGTMRELSHELVKAGIIEEMVEEALPGEDELLEEEGEEEVERVLEELMGKREAGPSVPVEEPGQEEEVGLEEDPGLEDMRQRLAILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L528</accession>
    <name>U4L528_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized GTP-binding protein YjiA acc. no. P24203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L528"/>
    <dbReference type="STRING" id="1076935.U4L528"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QEEFFPV"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
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                <person name="Gabaldon T."/>
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            <dbReference type="EMBL" id="CCX12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6237" checksum="8E454B3186CA9FDA" modified="2013-12-11" version="1">MPLGNMVLAMWPLPSCLRPPLSPLRTTSSSRSKRGFIKNVECELRACLSMGRNTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6A5</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="179" mass="19940" checksum="248878EC763D3F44" modified="2013-12-11" version="1">MKKVEEKRRARVGESEASGDGGNGDGSESRAKEAEEASEPKSKDGDLNAELSEIVKKVWMDKTKEPKEAPIKKVATGAKGPNVTLLEMLEIDCLEPTPRAGRPKLPPGEKERRRVEKGVAMKKALLEQRAKEATSSAVRRGCCIRRRCWRRGARRWCGERGNVMKCNNDEIGVKVGWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6M8</accession>
    <name>U4L6M8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6M8"/>
    <dbReference type="STRING" id="1076935.U4L6M8"/>
    <dbReference type="eggNOG" id="ENOG502QU8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VKRTNWS"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="373" mass="41749" checksum="95CF905096F77671" modified="2013-12-11" version="1">MNVSTDIRPSFGGFEFVLKTPTLMHAAAVALGGSIVYYSFNRKRIAGNNDSLLPATEKKKPAILEPLHNFTYQTTAPMTIRPYKPIYHLNMGIQSLSPNELIMLDRNYRMRLAKRRHLMRTHHNTTGSLSHASWAVNEFYTYLISNHLPTRFPTVFNKSPSGTLVLNQTTSDTYPVIPQSSQNALTALGENLDEDFVFLVPDAEGVYRVGAFVMCFPNGFDMSSKLGATMDEIHKPVPELQAKLGKSIERHFARMTPGVENGVKRTNWGIARSSELWTPQGTHVYDGEEIPEDVAINPEECCLRVERQTIWKLPGTGAIVFGIKTYLTPLSEIKQEAGEAEKLATAIEGLGDKMGRYKARGVWGRQVLQYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7M9</accession>
    <name>U4L7M9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7M9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651985" evidence="1">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="10532" checksum="46AEF119C03A9963" modified="2013-12-11" version="1">MKLTNLFMLIFVAISLTAGIPCAAGHCEQVSKLPSLPDASATISAPGAPTITLNGVSSAWKFVEVPSKKPLQFRKYAQLSKAPTATGLHVVPTIDAGLGIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8T3</accession>
    <name>U4L8T3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8T3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="16877" checksum="964C93090DB6F250" modified="2013-12-11" version="1">MCQQICQNRQRLGDGILEAHITRNYRQLNQENNNSSGTGHLEKFLLQALRFDQLDAYRASVKKYLKYGWPQDSTTRRGPMAIRIDALFYPVPQNFSTYICGQLEVGPQAILLALLDIPLPFLSPDLPQQDKMRNTDWSTYVPIPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4L974</accession>
    <name>U4L974_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCON_13196</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 100304</strain>
            <tissue evidence="24">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L974"/>
    <dbReference type="STRING" id="1076935.U4L974"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCX13603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="17327" checksum="846EEF42E4AE71A0" modified="2013-12-11" version="1">MSTSARRRLMRDFKRMQTDPPAGVSASPISDNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPGVKFISEMFHPNVYATGELCLDILQNRWSPTYDVAAILTSIQRSLLNDPNTASPANVEASNLYKENRREYTKRVRETVEKSWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9H9</accession>
    <name>U4L9H9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_06426</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9H9"/>
    <dbReference type="STRING" id="1076935.U4L9H9"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QCYEKDY"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="778"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="22">
        <location>
            <begin position="1072"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="677"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCX06839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1214" mass="135436" checksum="BE3692B39E5B4AEB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9V9</accession>
    <name>U4L9V9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9V9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="176" mass="20526" checksum="96D03D61E2566BCE" modified="2013-12-11" version="1">MSSVYQPYAGYMNHEPSNYAYSHYSAPPVAPDIRAAMKAISDRWMEQAKLGVDRMQADAESMKRNRNTNPSAFEQRMNQHKRQLKGEMDSVINRGYESIIHKANARPEYEHDAIFSLWQTISGRFMNFLNSIMHWIEQLAKAVIRCIQRAWNEVQSYFQKIREICGFAMCFVSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9Y0</accession>
    <name>U4L9Y0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9Y0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8671" checksum="F6FE26EDA9CA35F0" modified="2013-12-11" version="1">MDSVKTSMSITIPVIVYPHFFVNTINSYPPRYPRTSKPILHDELLANNSCIAATFLSAPDGSMRHQALLLLLLQSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA42</accession>
    <name>U4LA42_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA42"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="9944" checksum="36056F79E4104BA0" modified="2013-12-11" version="1">MAETTGEASRLQGSEEENEEAPTGILSYDSTTDIQWLWLKAELSRNALCANFGSSSPHRQLNADKGKKQTQSHKHPPSLPPPSGAGAIRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAE4</accession>
    <name>U4LAE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936136">
        <property type="protein sequence ID" value="CCX15142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAE4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14628" checksum="00F967AFDF3959EE" modified="2013-12-11" version="1">MTSTHPVQDQAGLEVAPPPYDGTYSNLELQPLGLSLPERYHNSRNANFHTDPEVLIGTYPESGSQPQPQPQRFIKQAQPKPTRAAIAESAASMAQLKKRQRKGKIQTIFCLLLMVGFLVVGGIIAGVLSYNANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAJ6</accession>
    <name>U4LAJ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Sugar transporter STL1 acc. no. P39932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936282">
        <property type="protein sequence ID" value="CCX15963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAJ6"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PIAFQCL"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX15963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="527" mass="58099" checksum="02514212D48D2E74" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAY6</accession>
    <name>U4LAY6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAY6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7083" checksum="6D2DED422BE7F9C9" modified="2013-12-11" version="1">MGKIKNPIPRGNDLCYPMLTKLPYPSCERSTQPSAFRSLGYCALDMTGWKTPHHTPAKTSNATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBB8</accession>
    <name>U4LBB8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02350</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="267"/>
            <end position="413"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="775" mass="88539" checksum="FC32864EF415580C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBG0</accession>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="52" mass="6189" checksum="B9C241ED22ACA9B9" modified="2013-12-11" version="1">MDFVIDLTNNRLGIYESVQTFTFLYMQTVDHAKAVYFTDFVVLLTLQLQYDF</sequence>
</entry>
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    <accession>U4LD25</accession>
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        <name evidence="2" type="ORF">PCON_07942</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="207" mass="22730" checksum="A664ABD6B2B386E8" modified="2013-12-11" version="1">MSKSSLVSIFRRSNPETPTSQKITYTLNPDSTVATTTFTCTTSATLPSYHIPSSLTTKLPSITLFSTDAGDGSSLPSYREVYKIQRLPFVGYQLTGNPRAQVHVSGNRHKSEVHLYSSVDGLVNGGEDRATMKLRKNVIIDSVTGKELATMFEYKTGGDKTLRALELTEGVGDSEKRRDLIVGLWAIYMWNLELHARTAPGSLGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDN8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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            <end position="674"/>
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            <end position="849"/>
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        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="897" mass="97238" checksum="A4180108B63ABAEE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEB8</accession>
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        <submittedName>
            <fullName evidence="1">Similar to Uncharacterized hydrolase C25B8.12c acc. no. Q9UTA6</fullName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <source>
            <dbReference type="EMBL" id="CCX29872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="300" mass="33170" checksum="29DE1364B913BE8C" modified="2013-12-11" version="1">MTIPKTPRAFPTPMDIKMIVSDVDGTLLDSHHLLPTTNPTHKIIRKIREVYPDLPVIISTGKQHRSTAELREQLDLHKFPCCHLNGNVIYNPKGEVVSESGLDKSIVRRVYDEMKAIGTSVFVYDYTTVYQLYHGEGDSGQWAQILRGYGELVVEGAEGIMEKIEAGELNPIKMAICQDAVTIASPKTILESKFAKEDFALTQALPFCVELIPSAHNKGTALIRLLKYWNETAAEPIGPDNIITFGDGENDVSMFRVSGMSVAMGNAMETARSEAIFSTDSNDEGGVGTFLEKVFWPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEF8</accession>
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        <submittedName>
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        <name evidence="4" type="ORF">PCON_08703</name>
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    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEF8"/>
    <dbReference type="STRING" id="1076935.U4LEF8"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="130"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="515" mass="57949" checksum="9EC7C1C59136B070" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEY7</accession>
    <name>U4LEY7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935850">
        <property type="protein sequence ID" value="CCX13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEY7"/>
    <dbReference type="STRING" id="1076935.U4LEY7"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIVLSQH"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32569" checksum="50657E301B459A9B" modified="2013-12-11" version="1">MDPFSAEGELLTLHNAFHQGLYSTVISFPISSLSASNQTTARILQLRARILSGEAVAILNEFELASADVEGSVELQAVKAFAQYITGDTEEAVAKVEELIKESKDNETVQVLGGMVLVREGRLEEAVEVLKGHQGCLEALSLMVYIRLSQNRTDLAIKEVTAAKKWAQDSMLVNLAESWVGLRQGAEKYQQSYYVYEELAQAPISSSAQTLTGQAIAELHLGRLEEAEVALKMALEKDPNFPEALVAMVVHNVLAGKETEDVMSTLQTAAPSHIFLQDLKAKSDLFDQAASKYSPKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF77</accession>
    <name>U4LF77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF77"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="162" mass="19148" checksum="11D347BE87B2420F" modified="2013-12-11" version="1">MHLKGKRLGARRRESKQRYRYLSSWANLKFKKTKAEIRSCTLMVAQAVAEEMTIIFPSNRELYDWGDFMVALEYGFHDAVNNAEYWDEDFFNWLLKGHIIKPRGVAHVQQVLVKRIPLRASLRQESRRLAREMEASQESINMEDNVLQDLAELEITDDWEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFW4</accession>
    <name>U4LFW4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFW4"/>
    <dbReference type="eggNOG" id="ENOG502S4VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWIFSWP"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="402" mass="46353" checksum="E82BECD2B1B92A2F" modified="2013-12-11" version="1">MGKPDDTKPLLSFDGPSRLEPYTDEEPGPSSKPAPAPKYTDYEPNSSYVVDDELPRDDRELPEYTEFLDPNNQGEQPPPFTKYAPSKHLITNGKTVSHDAHLNTDVEALYQWLVDETGVPPRPMLFIEGTHQVRNRNGSHNNNSSSNASSSTSSQTDFAIYFDLSSFLQDGTRLEAAPFDAKRRRGTVLTHAAEPGDIEAPKSVRDWCADYIHSSSYLKEFLFRKRVVGINEQVLRTHIEAIVRSTNYRGRLDIQFPVMNRSVVLAPDNWVCRIRYGWYRWIFYLTMLWIVIWPVLWFCTLKWEVVEATFEAKQGEERAWVDRWGWVLGKVVRQRRQGGVQSALKPEHLRWIETHEMDQEQRRQEQRLARGQGSGWWGAGFLNALRDMGEGMGEAAWGMDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG86</accession>
    <name>U4LG86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ankyrin repeat domain-containing protein 50 acc. no. Q9ULJ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG86"/>
    <dbReference type="STRING" id="1076935.U4LG86"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="747"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="839"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126836" checksum="604C9FFBDBC5A313" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGB1</accession>
    <name>U4LGB1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein sym1 acc. no. O14142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGB1"/>
    <dbReference type="STRING" id="1076935.U4LGB1"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMGITEC"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="197" mass="22003" checksum="94902C6A4157BA8F" modified="2013-12-11" version="1">MPVLTTMITNSTLSGLSDVLAQTLSHLRTKPTLPLKEKAPISISLNSSPSTPAPFTPSPQSTFCSARLIRYMSYGLLWAPLQLSWFSYLATTFPISIDNQATAVFLRVFFDQLLMSPFGLAVFFAWMSLTEGNGWGKMREKMDKVYWGALKGNYVVWPAVQVVNFWVMPLALQLPFASTVGVFWTTYLSLKNEAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHF2</accession>
    <name>U4LHF2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHF2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="7090" checksum="F6F2518CD8B08162" modified="2013-12-11" version="1">MLELSFTFVPLYRMAPLFMYIFRDYSLVLAICAVMVSNMDWGVRKMFWMRFVVDCMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIA1</accession>
    <name>U4LIA1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIA1"/>
    <dbReference type="STRING" id="1076935.U4LIA1"/>
    <dbReference type="eggNOG" id="ENOG502RXHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIGFEAP"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            <dbReference type="EMBL" id="CCX32034.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="1736" checksum="7602DF310C80BBB4" modified="2013-12-11" version="1">MATDFEGGGVITLVAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJM2</accession>
    <name>U4LJM2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 40S ribosomal protein S15 acc. no. P34737</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_05646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJM2"/>
    <dbReference type="STRING" id="1076935.U4LJM2"/>
    <dbReference type="eggNOG" id="KOG0898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTHCRDM"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX29575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="153" mass="17630" checksum="EE207B03AF705DF0" modified="2013-12-11" version="1">MADTEYDPVAAEERKKARTFRKFSYRGVELDQLLDLSSEELRDLVHARARRRFNRGLKRKPMGLIKKLRKAKKEAKPNEKPDLVKTHLRDMIIVPEMIGSVIGIYSGKEFNQVEIKPEMVGHYLAEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJN9</accession>
    <name>U4LJN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJN9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="21900" checksum="98F12AC2A62C9F5A" modified="2013-12-11" version="1">MPGILRLDPAILTIFLRYGACVNTRDIEGRTYIHQLFINDHRFLYDSVEYWLQRRECWIKMRHILAIFLGANFDIRANDKNSISVTDMAVVTGFQKIWQEALTSFGYDPIEVMSSELMVDLVSTTAGRTTTVGARVTTDEILCVHLFLQTNLRIERVGEGEGWENGDQREDPVSYMEERSEDKEGVWLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK60</accession>
    <name>U4LK60_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_12674</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK60"/>
    <dbReference type="OMA" id="TETFEHV"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX13081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9488" checksum="4645604DB5EF672D" modified="2013-12-11" version="1">MPVTINAVYTSPNDTNTFVIPTEAATAATEDSTQADQTNHVKAVREAVAKLQDQVNKYLTERMEVEKNDAAKALEDNYGEEVVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKB3</accession>
    <name>U4LKB3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKB3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5294" checksum="556FC791B84DBBBB" modified="2013-12-11" version="1">MRPGIQARNLSHLDTLKLGMLLKSEFMNILRSVSSRWLYSTNISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKY2</accession>
    <name>U4LKY2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKY2"/>
    <dbReference type="STRING" id="1076935.U4LKY2"/>
    <dbReference type="eggNOG" id="ENOG502S5NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFALGIM"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19671" checksum="F601C6DA28DED2F7" modified="2013-12-11" version="1">MMSGQLFSLFRVIELLTLIPIWGILAYFVNAVQPNTPDDTTLYVFIVPILATVWAFFTLLAYRRTGFVALYISIIDLIFFGLFIGGAVLLAPRARWTNCVSSTVSWEGWQVVANRNCMMWKAAWGLGIAEILLFFITSMLAAHMWHHSGAVIVYEERRHVHRSSRNHRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKZ7</accession>
    <name>U4LKZ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKZ7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4894" checksum="3E4EA6C78DE88EBD" modified="2013-12-11" version="1">MQHNQSHGMWASHCFSYSRAMNFSENVVRHWRRRARMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL45</accession>
    <name>U4LL45_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_13519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL45"/>
    <dbReference type="STRING" id="1076935.U4LL45"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EAIMFGM"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="449" mass="49677" checksum="A3F864724F56816F" modified="2013-12-11" version="1">MSPPPCSTADLAPTNLTSTVMTNGTGKLTKATNGTALAELDPSKLKVTITSSPKAYSSPDSTQWGMMDATTDHMITARWTDTHGWHAPELRPYARMDLWPTASCLHYATECFEGLKAYRGFDGKVRLFRPSRNAARFLTSSTRIACPTFPPDAVEELIKALLAVDAAKWVPEPGTFIYIRPTMIGTGRALGVQKPREALFYIIMAQFPKLDNPMKLLASSEDSIRAWPGGFGFAKVGANYGPSLMAQKEAQTKGYDQILWLFGKEAYVTEAGASNFFCVIKSKTTDKLELVTAPLDDKIILDGVTRRSVLELARERLADEMDVVERRYTMQDLAEAHDEGRLVESFAAGTAFFVAPVTDIHFRGKDIRPAKGGEEGTYTNKIKSWLVDIMYGNAAHEWGVVVEEKGFKSEDLAEEEIEALMEKIKTLKASKAWDAAMERMKTEELGEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLR1</accession>
    <name>U4LLR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLR1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="324" mass="35733" checksum="3C283E3F991A234C" modified="2013-12-11" version="1">MAYPLMDCLINGEPIQPSESRAHPALLGYENLTLLQKVSLIENCGYGEYSHLDQVHAHPAFYNPMRHYQQERNLCIAPVRLSLNPLDPMHYGSDPAKSSGPDQTPAPGIRVMRKRATYQYQTLPKEVTAQKTHNGIRTSTVPLRNSTITVQDKKRAQISRQATTSTSLLESQKTFNRSRSDRIHNKETAQGTSSNAHPKKIDIPTQVQKHVVPVAISTPPDVSVPQISNSHSDLILNTITTYSRAAAAQAKDTPEPDRDKAKQAKLPLTPLTAHSLITPAATPSRKRLGSNESAVESPAKRTQQPKRACTKTSRTSNPNYVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLT7"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5051" checksum="5763D4A25419AEC0" modified="2013-12-11" version="1">MINGIITFIPPIQSDTSLMCFPHERGSVLPRLPSNGTEKPTLVTGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM18</accession>
    <name>U4LM18_PYROM</name>
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        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_14008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
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    <dbReference type="eggNOG" id="ENOG502QV0U">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651478" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="605"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="605" mass="64258" checksum="2E76B4F973592082" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM72</accession>
    <name>U4LM72_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_14274</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651566" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10613" checksum="25630E2D0C61D53A" modified="2013-12-11" version="1">MKTTSLFTALLLSARFSLSTAAVTPRANEYTMIQLYSSSNLKDKFLDDRWYPKEKYTGCIILADKLVPEMHKNKMQAFRCNNGICYQREYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LML3</accession>
    <name>U4LML3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27235" checksum="06063F14F0FA41A6" modified="2013-12-11" version="1">MITDPSPPPPDDSKTSKPLSASPATDSSKILIFHATTYPLPAAHIAQFRECINPAYTLSEKGLFDHLRIPDEDATEFLTPGRWIFACYVPNSTPKDGSEPLLQPATDYLGITHDLTGYSMAGTVSISMPPYPRTPYTPGFPIFPGTLEVDEFHLHLLVTSVNHKQIGVAARLLNAVQDFAASRIPKGKQGKIVGEVLEEVGNVPYYVRRGFIQEGEKWCCPPGTWGSIERFHLRRMVRRVEGCATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMX0</accession>
    <name>U4LMX0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13782</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMX0"/>
    <dbReference type="STRING" id="1076935.U4LMX0"/>
    <dbReference type="eggNOG" id="ENOG502R2TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMIAMSH"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="320" mass="33870" checksum="3CF18E732F76EBA6" modified="2013-12-11" version="1">MSGYQGTPPPPQPQGGYYPPPPEKSQQYPGQQQQQYAPQSPGHSQQNFYPPPPQQYPPPTSPPPVTQVAYDPNRPVLAASAPVAQGGASTVTDTIGSFNGGNYRIDHRDTNTLLTIQLAHGCPITAKPGAMVAMSPSVTLKGQVKFSFKKLLAGGEMSQSTYTGPGELLLAPAALGDTVPIRLDGQQTWSVGRDAFLACTQGVIKEYKSQGLGKAMFSGEGLFVYKISGQGVLFVTSLGAIIQKNMAPNEQYIVDNEHLVAWNCKYGIERVASGGIISGMASAEGLVCRFTGPGTVFIQTRNPKAFGAWMAQHMGAGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNB6</accession>
    <name>U4LNB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNB6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="18218" checksum="C470F44080EEC81A" modified="2013-12-11" version="1">MKSMRLSYYFSDSEVAILQKTSVFSNWKHPTLEYTCINSPVCIYSLYIPPLHNHLLLINIYPVTNTKYVDYLLSSSHFIRNTLTNTNIMTKPSLENNLVTIVTGPTRVILGGNWMFYEQLARETLWYVRRYTYGDVCWYAWQVTCTYQEQAPTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNQ2</accession>
    <name>U4LNQ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(adenine(34)) deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_14252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNQ2"/>
    <dbReference type="STRING" id="1076935.U4LNQ2"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052718">
        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000039">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="345" mass="37633" checksum="9F9EF0A6A034E2BF" modified="2013-12-11" version="1">MTTEEMEIDPPSPLDPPSPPSAQLLQEMNSSLSPAKMELPPVLPMVPADDLETHRHFMRAALDMADTALKTDEVPVGCVFVHNNQIIGRGKNDTNRSLCGTRHAEFIAIEHILRDYPAEIFQDTDLYVTVEPCVMCASALRQLKIRRVFFGCLNDRFGGCGGVLKIHEDVCVEPGYTVHGGINHDEAIMFLRRFYIQENERAPQPLAKKTRTLKTEVLPFGSGFPRDNAGRNRKKEALLVATGQLDRSSLPPRRKSEANSDPTSGSGGSQTVNPATTTPSATATRPANFIPQTKPISPPRSPQKAHATLAITNPAQKFAPNITNPMSRPTVKLPTVSPGSANLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNU9</accession>
    <name>U4LNU9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNU9"/>
    <dbReference type="STRING" id="1076935.U4LNU9"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="APVHDFV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="229"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="536"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="976" mass="108156" checksum="17E32114B11CF18D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPD5</accession>
    <name>U4LPD5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062421" evidence="1">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14505" checksum="6758E974D222699B" modified="2013-12-11" version="1">MVSFAFLCFPWPSLAFLCLLLCFCASCPTVLRTLLTSALPAPMTTILVVSEKMLAPVSRFFVIQESEYAGSHTADSPKQGSPGPQALRVHNWLERCTQDASNDDPADTTLPTVDGATQNIADVGQLFKVLELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPT2</accession>
    <name>U4LPT2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pre-mRNA-splicing factor cwc26 acc. no. Q5AWZ6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LPT2"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GDVQRQE"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="321" mass="35670" checksum="C4EDE03F0372F60A" modified="2013-12-11" version="1">MSGSSLAAYLAKNYLTADAPAKKSTKKRKRKEGAATVEAGLTINDDDATTWNDNANKSDDEDAPVILGGIQKTFKKKTTSGWKTIVEAEETAAADKILAANMGDRVQDEEPAIEDTEGVLKMESGVHAGLQTGAQVAAQLAAAKEAERKRFMEADPTESGRGQETIYRDASGRIINIAMQRAEARKKIAEEEEKVLREKELQKGDVQKIQAEERRKQLDDAKFMTLARYADDKEMNEEMKDQDRWNDPAAGFLTKKKGAGRSKTGRPVYMGAAAPNRFGIRPGHKWDGVDRGNGFESKWFMAQNKKKETVQRRYESMMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRH0</accession>
    <name>U4LRH0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRH0"/>
    <dbReference type="eggNOG" id="ENOG502T2EJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHFPFGS"/>
    <dbReference type="OrthoDB" id="5397723at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="13772" checksum="86F0D3F9CE41AA54" modified="2013-12-11" version="1">MTGAPVKRRSPLTPPSVTPPSVTVSESTTLPGSRDRCKSPCSRASALLAKVAIVSSTPSTVPSSPRLCGASSPESANSTPTATPPDDCGQFPFASTKQLPESPEGGYVSFPMFEAFGDYAQDQEDGSVSPTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRT2</accession>
    <name>U4LRT2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_04160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRT2"/>
    <dbReference type="STRING" id="1076935.U4LRT2"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTANWRS"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="47"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="702"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="796"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="958" mass="104411" checksum="6D0C3C5CAB2B95CC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRT3</accession>
    <name>U4LRT3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRT3"/>
    <dbReference type="OrthoDB" id="10398010at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="439" mass="47448" checksum="4B8F688155C55103" modified="2013-12-11" version="1">MKSSPFSHLRPSLHLLLRLPDILESNSFPRKMATTITSFEIESNEPMKLTASSPGPEPHTAETIASVYLESLDFEPKSSEDMASSGSSIKDSVNAKLPETSLSPTPKSPNQEDPTLSSNSESPKAIISDPTPSSDPETTSGSTSSPSATNNKFYFQRETHASYRSSAILTFSVNPDECKPVYTIKHHPQFVNPLSFLPYSKKTGPDITLYRGGKSDGDAGDATGAQEVVATATIKNSIFAKGLGEVKISGTSSGAVSEVFKIKPNPQVGHAVFTYAGKQLYWLITASQQPPLNAAQQNTTPPVEGENQPRAGGLRGTLNDVISKKREVLLIHYTAKLMEVTEAAAEELAVYEDIMPINPPTTREFIWENGHVGILEFKQGLVKRHEVSGEFVDAATAALVLMIERAKRGMKTVGKGFNSVLWSYVIPWNGGGFMGDIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSL9</accession>
    <name>U4LSL9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_04017</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LSL9"/>
    <dbReference type="eggNOG" id="KOG0208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSCFQYM"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase"/>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
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    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1218"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1259"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="154"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="374"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="698"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1311" mass="145739" checksum="7336BA308001ECEE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSX0</accession>
    <name>U4LSX0_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_13330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LSX0"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="20828at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1360"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1392"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1428" mass="158259" checksum="086E97F9F9909F47" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT69</accession>
    <name>U4LT69_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT69"/>
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                <person name="Kumar A."/>
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</entry>
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            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="649" mass="70144" checksum="0B6F87476D5BE949" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTN1</accession>
    <name>U4LTN1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Sporulation-specific protein spo7 acc. no. Q9USQ0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTN1"/>
    <dbReference type="STRING" id="1076935.U4LTN1"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENWDEYR"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="400" mass="44917" checksum="D4049554647E71FB" modified="2013-12-11" version="1">MLSMTTSMDTSDLDLRVKGSLPSGSPPAYHQPPAQPKDPLEAAPSSPSQIYLNLLILEASLRSQYLNLLARRRKFTFFLLVLFLWISFFYYRFFILGGSPYYYFSLFEKLGLGGGVGTGVLYYATGLYHKTIVEPRRFVAIANRGIRGFNVKLVKQPLSYKEWINWWWDWYTFRAPPAPPLAATPASRRLSANTRRPVIPPVIGHRHTGSFSSAQAQRPVIKPGPSTDDDDDDDEVEEYLPGGLHVKLVIMPKGFSPDFREGWEVYRTEYWDKENEIRAVRREEIKRNRHKITPTKPATAEVKVRHSSISLRNRTPTPDPESKPVTGRPRRGSTASLKRRSLQGMPGVAGVSRASTPGDISDSGSTTSALGEGRNRTPRKTGKGRGKKRAPRNDESAVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTT9</accession>
    <name>U4LTT9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTT9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="13624" checksum="537D53BA43DAD662" modified="2013-12-11" version="1">MAFRKEGAEERKGENNICLEMCRLRKEKKDESTKPRSHKKQKDASRLLRVSDDNSEIYKEPRVKWLEEEKKRGEKRNKGLKEKTKNTVSSKASTTFQVRSEQEGSQVALFTLKCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUQ9</accession>
    <name>U4LUQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUQ9"/>
    <dbReference type="OrthoDB" id="5337208at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10194" checksum="D85D1283C5545EB4" modified="2013-12-11" version="1">MGNQEIPIRSPTPAFTMDVYTKSEASTYLMSQFFYMPSDTRSIWAITFSNTNAQLIAAAYTLLITSSSSSAGVSSSVWLPHSSKLKTIQTATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV53</accession>
    <name>U4LV53_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935734">
        <property type="protein sequence ID" value="CCX32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV53"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17928" checksum="440D36530E9B7FB2" modified="2013-12-11" version="1">MRLLSMRKHGWLCLMQRTSCESPTFARRSSAVVKLSSRCKIKKITPTVIFFPILNPRPVLSKTKSTQPAFHHRPAAKNVSDSDPNLQPPPHSSLRLRHPFLFPLQFPNPQPHDRSAHLFPRGINYLSRHLLSLPCPGIYLPQHPTPQHRPPTHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVI5</accession>
    <name>U4LVI5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Acyl-CoA-binding protein homolog 3 acc. no. Q20507</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVI5"/>
    <dbReference type="STRING" id="1076935.U4LVI5"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMRRKKD"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="385" mass="43079" checksum="ECD7D8212827B0D5" modified="2013-12-11" version="1">MLFTPEPPLSPRLNTTTPVTSASLIHPTSTNNALTESRVIQQSLGSHSMRGMRRQSTMSDSVDRVFAHALQTVRKIPRTGSSRPPPEARLKLYGLYKQSMEGDVTHVMPRPPDPVPPDVDIAPDENLRAEIEKWDAWYAQRGIPKTEAKRRYISTLIETMHKYASFTPEARELVSELEFVWDQIKTNTATSSDDPPSPPTQAPLTTSNLTASNLFNNASTSFVVPGSAYQTPRLNANPDSDDEDDAGPQGLGFISPAPYAASAASSSPDPPGPGNPAGGNKIWRSRVEKALSKMTTEVAALREQLESRREERRKAKSRRVWVWFLWGCWAVARHLVLEAVIWGVVLFWMRRRGDRRAEEALRVVGRFLRNGLREMGFRGRRGIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVV3</accession>
    <name>U4LVV3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVV3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652447" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8412" checksum="E593567006357EEF" modified="2013-12-11" version="1">MLFRLSLLWALLRVFGALPGRSRVTLLLFTVPPLCRFYRSAHFTVGPLITNRMTEDPKNVKSIISTATRTSPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW54</accession>
    <name>U4LW54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW54"/>
    <dbReference type="OrthoDB" id="10393739at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="321" mass="37410" checksum="C2553E7ECBA58034" modified="2013-12-11" version="1">MESFLYATKYIARLYVESISHLYSVTADYVSPASEAATHYHPELEAPSSWELYLSNTKAPRIPEHKLHEDTLKTFDIHLGPDPIVRAQPCLNAEDKTTHYHHNLNEFPPAGEKYRLLGGEYGYSLTSFEQIRSRYCHHKYGRIPPMAPRIVKTLAEDVERKISLEAFPEDASYLSRFWAPRIYEASWQWTIWFGLNPRHVHRDWEQDGEGNWSRAYNMLVQQDSGYNSGAECLEEQEGKEAREIREMVEREKEAQKIERARIPMTEPKQDGPKISFLTEKKAEEAEEEKEERRRIQAEKDAAAKKAIDDAFNSVVWDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW85</accession>
    <name>U4LW85_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW85"/>
    <dbReference type="STRING" id="1076935.U4LW85"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RGKIYKS"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37713" checksum="552FA0564A267E0D" modified="2013-12-11" version="1">MSVTRPLARLRSAVTPFLQAPGARTFTTSPASHLRRRPSPREIISSMGRELAPETAPYTETELESLRRHFSPEQVQALLAGEKAIDRHDFELRSERRRGDPWGLSYVTDLSTIDPILDFAPTKHGFEAEGITVPKRNVPGIQDPYVTFQDDDADSTLFKKLAQRTGMQEKDLKGLQTRLMVTHSVTNQTRMGKIRKIYALAVAGNGNGLLGIGEGKSVESEDAIRQATYMAMRNMEPIPRYEGRTIFGNVKAKNGAVEMELFARPPGYGVRCSSHIFEMCRCLGISDLSARVTRSRNPMNVIKTFMQALKSQKLPETIARGRGRKLVDARKVYYGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXL5</accession>
    <name>U4LXL5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXL5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652024" evidence="2">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="10138" checksum="4646821FAE8C93E8" modified="2013-12-11" version="1">MSRNQLLPRLFPLIQLLAMSSSASAAGRMCKGTKEENPECWHLSLILTIILVGLIVAIILYYFLQLCYILFFRDERTERQEGRYTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTX1</accession>
    <name>U4KTX1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_01277</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTX1"/>
    <dbReference type="STRING" id="1076935.U4KTX1"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAFQIIQ"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX04257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="439" mass="47421" checksum="B7470FEA8B5DA3B4" modified="2013-12-11" version="1">MSRFETLCLHAGQEVDSATNSRAVPIYATTSYVFNDSAHGARLFGLKEFGNIYSRIMNPTVDVFEKRIAALEGGIAAVAASSGQSAQFMAIAALAHAGDNIVSTSYLYGGTYNQFKVMFPRLGINTKFVNGDDAAAIAAAIDDKTKAVYIESIGNPKYNIPDFEAIAKICNEKGVPLVVDNTFGAGGFLVRPIEHGAHIVVNSATKWIGGHGTTVAGVVVDSGKFDWGKHAKRFPQMVEPSEGYHGLKFWETFGPITFAIRVRVEILRDLGSCLNPFGAFQLIQGLETLSLRVERHVSNALALAKWLQAHEKVAWVSYPGLESHPSHEMAKKYLKRGFGGVLSFGVKGGEKAGVTVVDNLKLASNLANVGDAKTLVIHPSSTTHEQLTDEEQLNSGVTKDLIRCSVGIEHIDDIIEDFTQALNKLDVSEVAEQVEKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU25</accession>
    <name>U4KU25_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized protein C1259.12c acc. no. O94712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="HF935214">
        <property type="protein sequence ID" value="CCX04683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU25"/>
    <dbReference type="STRING" id="1076935.U4KU25"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPTRWNK"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="100"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="382"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="574" mass="63301" checksum="555FAE70FD6B32F3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU74</accession>
    <name>U4KU74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to UPF0480 protein At4g32130 acc. no. Q8VY97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU74"/>
    <dbReference type="STRING" id="1076935.U4KU74"/>
    <dbReference type="eggNOG" id="KOG3306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTFGMPK"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650835" evidence="8">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="228" mass="24581" checksum="8130AA746AA460CB" modified="2013-12-11" version="1">MKLLAPLTALYLLASASAATVRGLIPASTVLPNPSELPADTTITLTTAGELHKTFLRWDNTFVFRNVSEGSYVLDVAAEGYAFSPLRVDVGKGEEVAVKQTWRGRAWSNTGESKGVPIELRPIQATSYYQVREGFNLLKMLSSPMILIAIVSLVSIVFLPKLLDKMDPEFRAEFEAHQKKNSVTTDRMTNNIANFDAASFLAGMGKSSTPAPAQASGSSAGQGGNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVA2</accession>
    <name>U4KVA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein unc-45 homolog A acc. no. Q9H3U1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVA2"/>
    <dbReference type="STRING" id="1076935.U4KVA2"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NLQHWGF"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="347"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="724" mass="82169" checksum="E822E74FE604E3CC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVD2</accession>
    <name>U4KVD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVD2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="8548" checksum="B073481982908FC7" modified="2013-12-11" version="1">MLCLRLPKHILRLDLPSIGMFEDQPLQRCCRCKKQHRNLYYCTPCGKIRCEKCQVNKIPKSRPYARSLLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW15</accession>
    <name>U4KW15_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW15"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="16918" checksum="C4218C5FA4A7586A" modified="2013-12-11" version="1">MTITIVRPIDSGIQTISYLNPEVLPQLPSILLKEMMHAHASGFIPNIELTKSYKLKDLSLKMEVAEIRARSHEIDISFAQLYAECFDLIINMSTGVFALGEAFDEEIRNARASYLYVPLSENRLGLAMILTTFLAECLGAIEIASLRSHCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX08</accession>
    <name>U4KX08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX08"/>
    <dbReference type="STRING" id="1076935.U4KX08"/>
    <dbReference type="eggNOG" id="ENOG502RZDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QHAMNSG"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="273" mass="30853" checksum="BE5CDCC94596DB6F" modified="2013-12-11" version="1">MPSLYRLLGLGPPFDATRFTTSYLLPPVVLASCRLLIGLYAIVTNVSKLIIDNTPHSREQHWSYFTNITYWSLGFYFLFAAYHTFVYNAKGVAPLQTWYRPLQAAHLVLWTTVVIFPLLVTAVYWGILAPTDSPFRSVYSGWSNISTHALNSFFSLFELIFSRCSSPPWFHLVPIILFLAGYLGVAYITYATQGFYTYAFLNPENGAKKLAIYIVGILVGVCVVFCVVWAFLWIKNWIAGKCGNKGWLSGRHSEEQQAEMGFESAKGREMSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXK4</accession>
    <name>U4KXK4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to RNA exonuclease 3 acc. no. Q5AL29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXK4"/>
    <dbReference type="STRING" id="1076935.U4KXK4"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWRTPWS"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="242"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="485" mass="54714" checksum="12662CFD20FEA322" modified="2013-12-11" version="1">MTNSNYNELSNQKLVPKRSEPCQSLAEKSDVTTYDTDSGDDSAVDIADIWLPTEGTKQEEPLSSKKGPIVEIEKPGQTINPKTKEAINMMKSLPQGVTWDHVEYRGHTWSVVPKDLCKAVHRVLQKLCHEPLDLYDAKYTLHRHTPEAIARMQKCYICSGSRTTPTCSTHPGKQFQRLNRETNNQERHWTCCTTVEVVSRKSKRKPGCNPLDKHTFEDLEGLAANFDFIETPAPITGTPKRKAVVLDCEMGGSRFGRSELIWVTVVDFYTGEDLVHDFVKPSTVIVDWRTQYSGVSEKMANGLEAKNHFINGWQQARELLLQHIDSDTIIVGHALNNDLDQLRLIHHRVIDTALTIPRIMGKKHSIQCLSLELLSKAVQNGTNGHDCLEDTLSARELLIWYLRHPDEVLDRTHQNLREYAEANAEAAIRKATLAALKQESQAESILPSKQWTPEQRALLQQLLATGLTTRDVVAECARVDQSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXT8</accession>
    <name>U4KXT8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXT8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="353" mass="39727" checksum="900A0D6DB53ABF31" modified="2013-12-11" version="1">MIEERYPRGHGTTIQIQDSDSERDSDSDTPDTVEYPEILYEELQQFCDNVEGLRHIRGIEMSTPTTPHFVLESQEEQEQEQEQEQEQEQEWQQVQYQEQEQEQEQDQDQEREQEQIPNDIVLEELPEASLDNPILDRLYTLIQNGQYPVLFTPIPTSTPVPAENNSPVPFLEDWTVLLDSPNMAYTNPRSPSPNPHRSQSPSPRRSQSPSPGSPRRWRRWRARPRVPSTIPSTAPRPRSRLVTSESVGSAGSPENSGSSGNPESSGNTGTRWDELIRLATSLRCPEISSAQIQRIQRMVRVHEDQMDQMDVDRDSGIVTGESDNEVRPVPGTPVTPGSAGSSSSQGSSESLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXZ2</accession>
    <name>U4KXZ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Glucose oxidase acc. no. P81156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935315">
        <property type="protein sequence ID" value="CCX06811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXZ2"/>
    <dbReference type="STRING" id="1076935.U4KXZ2"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RESWFLI"/>
    <dbReference type="OrthoDB" id="4815907at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650854" evidence="3">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX06811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="280" mass="31292" checksum="B6A8F10A6622A35B" modified="2013-12-11" version="1">MRFPSSHLQTLAITCLFTLTTALPATVIKREEDLKSSYDYIIVGGGTSGLVIANRLTEDPKTTVLVIEAEFHLSKKMKSFPGYVGRTGAKYEWGYNTSAISGLNDRKFRIPAAKVVGGGSVINGMFYTRGSKEDYDSWEKLGNPGWGWEDLRKWFNKSETFHRQPEDSGVTFDLSTHGTTGPIQTSYPPLRYPQLRESWFLIHVNHELSLTAGVRAEKIINAMKSFGIPTALDGTNGHSLGKFWVLNTLDPRNQTRSYAQLIMTQPSRGKLSFDHTATSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY47</accession>
    <name>U4KY47_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_06689</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY47"/>
    <dbReference type="STRING" id="1076935.U4KY47"/>
    <dbReference type="eggNOG" id="KOG2215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="441"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX07102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="658" mass="73804" checksum="4A7EC455C6D98F0E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ79</accession>
    <name>U4KZ79_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935331">
        <property type="protein sequence ID" value="CCX07020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ79"/>
    <dbReference type="STRING" id="1076935.U4KZ79"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADYWDPE"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="154" mass="17062" checksum="856CEAD41A6E28E1" modified="2013-12-11" version="1">MSDDGYANDEPEFNEDFDEPIDDFDEEPTFSDNEDNGNDAGANGNMNHDFIASGDPAAAAAAAQGGSKGKLEDKKIPDDQRNTTPYMTKYERARLLGTRALQISMNAPVLVDTGGETDPLQIALKELQEKKIPLVVRRYLPDGCYEDWRCEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L008</accession>
    <name>U4L008_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L008"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="22207" checksum="ED5B76218C478CA0" modified="2013-12-11" version="1">MAPSAIVQVGQISDDEAPNADDSGDEYYNSPEDSAYQAEDGKESEEEENVEITSESSGFLGQSPRQYAELLAAGVVTNGELIIPAPHDDESDTHHPGFIDDNYGKELRTIETEYKLPQDDDPPQDWFLDNQGPASIELELYGMGLQEGSWDDFLFEQLPPEVSHSINNYNTQGNYIEPNVQHQALFFDNQIQYASRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L085</accession>
    <name>U4L085_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Kinesin light chain acc. no. P46822</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L085"/>
    <dbReference type="STRING" id="1076935.U4L085"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MARGQRY"/>
    <dbReference type="OrthoDB" id="4358462at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="168" mass="19782" checksum="59424D98B21CBB2B" modified="2013-12-11" version="1">MAVLVHSSSKSASLRSKAMARGQRYFRKSLPDAQALSRRKHPDTHRCMSYFAATLRHQKRFKEAEQLQKPLLELRKDILGDDHQDTQNTVFYLGCNLYDQNKWEEARGYFETDLRYRKEFLGEKDQETLDCMNYLAGTFLHQGPYEEAKEIYTKICDIRREVLGENHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1A9</accession>
    <name>U4L1A9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1A9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651584" evidence="2">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="11816" checksum="98B5247C2FC92AC2" modified="2013-12-11" version="1">MKLNPLYLLPLLSLLVTAAPVPAPAPAADPVPARSWTPPTPPPTPPGSPNPWTPPTPPQTPPNSPHNSPPNSPSGSPPGSRPGSPGPPPSSPRSPPGSPVRGSKPRRDVRKAVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1C7</accession>
    <name>U4L1C7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to CWF complex protein sap61 acc. no. O59706</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935444">
        <property type="protein sequence ID" value="CCX09206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1C7"/>
    <dbReference type="STRING" id="1076935.U4L1C7"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPKAFQK"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX09206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="494" mass="57954" checksum="6023677C4D69C58B" modified="2013-12-11" version="1">MAILEEQRSLCEDLERLEQACADRILEDPKNVRDRLARDHQITKFVDRFQQQSQRLVEIKKDKDGALQKEIDSLTTHDPFEEFYKQLNTIKNFHRRYPNEPVENLERAYKRRPTENGAIPDYIAEIDAMFTGEESNGRFFDLTKQHEEYLNLPGVKRVTYLQFLSVFDKFSHFTQQQKRNEKYFVYLTELADYLESFLRRTRPLEDPDRIIDTLEKEFTKAWEADEIPGWGKSADTKAAPTQEQADLWCNACQKAFTNKNVYDHHFSSKKHKKAAESNTVDGTASVENAKKAELARLKDRAIAEREWRITKLTDIMKEQREATTTNVERKQSLTERERQMELEALYAEASEAPQGDAEASDEEKDDDSKIYNPLKLPLAWDGKPIPYWLYKLHGLGVEFPCEICGNFVYMGRRAFDKHFNEHRHIHGLRCLGITNTTLFREITKIDEAQRLWEKLEGDKKRQKVQAETVEEMEDAQGNVMPRKVFEDLQKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1L5</accession>
    <name>U4L1L5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Probable acyl-CoA dehydrogenase acc. no. O32176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_05695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1L5"/>
    <dbReference type="STRING" id="1076935.U4L1L5"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQPVMRQ"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="517" mass="57494" checksum="93E44994B27D4B1A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L239</accession>
    <name>U4L239_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="HF935440">
        <property type="protein sequence ID" value="CCX08990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L239"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="514"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1391" mass="159145" checksum="4F0A975FE8F9E9C4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2C7</accession>
    <name>U4L2C7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_06015</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="HF935289">
        <property type="protein sequence ID" value="CCX06428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2C7"/>
    <dbReference type="STRING" id="1076935.U4L2C7"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="534"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX06428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="618" mass="66437" checksum="C4785E79F6BAC028" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2D5</accession>
    <name>U4L2D5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to DDB1-and CUL4-associated factor 4 acc. no. Q8WV16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2D5"/>
    <dbReference type="STRING" id="1076935.U4L2D5"/>
    <dbReference type="eggNOG" id="KOG2695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QANHTAP"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="48909" checksum="5B292F5121B8BA6B" modified="2013-12-11" version="1">MQPPREIPGFYYDPEKKKYFKILPHHAAPTAAFHTNTSIAEKNREKRRIEDLNSLTLHRAKRTRRTPLKANPCIRATLYRELTGDRSAEAIRSIYARGLQRKVVWEADPGVKLSAFTTHTQADGTEFCIIGTVAGDVRLSPLVKKKEGELQVNMRESDQIIHGRSQISSVSVNSQGLVMATFMGGPNRPPAIYCHWHPSTSSDILHPGPALFGFNRNHNITSVWTSAASPNPQGDLVLGTNQGAVHIEVRPWNLEQTFQPIKSDVFAVSFLPNDPNPYLTGSRDGDIRIFDIRAGRDNRPVVMFRHGGPVTHIRNLAQNRIIVNGLQRCASYDLRYPHKKGPSANFGATSRAMRDYGQVGGEGSSLGLGFDVDVKRGLMVVAQQDGWVNLRSLETGEKIPSPLAKNRWDGLCKGLRFDEGEVARVWGIEQRWVVAFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3A1</accession>
    <name>U4L3A1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935547">
        <property type="protein sequence ID" value="CCX10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3A1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="8064" checksum="0D848088AC0A6FE3" modified="2013-12-11" version="1">MSASNGNQPLAGNKPYTVLIWDCVDLNNHKLYLKTWPGYKGADKKYEKAADNLCYLENVLDARHTFEFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L413</accession>
    <name>U4L413_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_10520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L413"/>
    <dbReference type="STRING" id="1076935.U4L413"/>
    <dbReference type="eggNOG" id="ENOG502QSQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WDRSENE"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="51"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX10926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="351" mass="38466" checksum="68ABE6ED56FAEFF8" modified="2013-12-11" version="1">MLRVSYLALLCKMLFVRLSSIFFGAVSLLSVQAAVIERRSGRTSPPSGCIVVSKSASSGQFSTVQAAVDSLSTTSSAKQCIFIYQGTYTEQVYIAPRSAQLTIYGYTTDTSSYSGNTVTITQSRSQDNVASNDLTATLRAWNEGLKVYNINLQNTRGAGSQALALSASNTKQGYYGVKFIGYQDTLYPNTGYQVYAKCYIEGAVDFIFGMQARAWFDDVDIRIKGVGFITANGKDSESNPSYYIINNSDIRVADGVTLPAGSTYLGRPWRNWSRVIFQNTAMSDVVNSAGWRYWNVGDERTDHVYYKEFRNTGTGASGTRASFSSSLSAANPITLLFGSSYKSWVDTDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4A2</accession>
    <name>U4L4A2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935333">
        <property type="protein sequence ID" value="CCX07128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4A2"/>
    <dbReference type="OrthoDB" id="10592484at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651648" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="13311" checksum="9BEF279A02942F88" modified="2013-12-11" version="1">MQLLNLFLALGLIAAVSASPAAGPQDVGSSSVIPTGIDFAAIDAEIREQGSSHELAFRLHPSPLRQPVPDVKGQHLCCSNGGCCALDHPICCRNLSYCGVSIFACYGVDIPGTPGNPGWTPVPDNGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5A6</accession>
    <name>U4L5A6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Uncharacterized helicase C550.03c acc. no. O59801</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5A6"/>
    <dbReference type="STRING" id="1076935.U4L5A6"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="303"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="579"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX05230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1254" mass="140872" checksum="59D3F4635B85BCC4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5W3</accession>
    <name>U4L5W3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5W3"/>
    <dbReference type="STRING" id="1076935.U4L5W3"/>
    <dbReference type="eggNOG" id="ENOG502S9FC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="238" mass="26899" checksum="A349EC69E5C14567" modified="2013-12-11" version="1">MAQRLHKKLWGDEVATPVDPYTRRIEQPVIPEEEINRENYVEALDARELPVLGLDVPLGTWEMDSFIPTTTLTETVAIHRAVHQAFVEVTEGVEPAEPAVESAEESQPQWLEDGLSGQGWVQTPVENLDVKFAIVKRILQLTGQKVPDATTSRAKTIADILEPLITRPKPKKLAEELAMVDELVALPNVKLHPTKVRRSDKERVIGRALPRHEEHDHVYEGIDVRVKPFKGHVTFKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5Z4</accession>
    <name>U4L5Z4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_12215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="HF935721">
        <property type="protein sequence ID" value="CCX12621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5Z4"/>
    <dbReference type="STRING" id="1076935.U4L5Z4"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="10">
        <location>
            <begin position="42"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="9">
        <location>
            <begin position="235"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX12621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="533" mass="58744" checksum="007BB4FD5E9CC64E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L610</accession>
    <name>U4L610_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L610"/>
    <dbReference type="STRING" id="1076935.U4L610"/>
    <dbReference type="OMA" id="CHEPQAD"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651319" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="131" mass="14527" checksum="D4E6C451B7301658" modified="2013-12-11" version="1">MMEIISIVALFINAVAAAPPLPPGVSRNTVINWDRPFHGGILGGVYYCDDIKWGKTCLYGAYELAKCHDVPNNWNDIISSFGPDKGTYCFVYEDVNCVGDSRLMQYPGSENLLRQGFNDRISSFSCGGYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6H5</accession>
    <name>U4L6H5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to 3-hydroxybenzoate 6-hydroxylase 1 acc. no. Q9F131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6H5"/>
    <dbReference type="STRING" id="1076935.U4L6H5"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEIIFNY"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="465" mass="52330" checksum="483093C0B465661A" modified="2013-12-11" version="1">MASPIAEYPKTGLKVVVVGAGFGGLTAAIECYLKGHEVVILEKTPTWTQLGDIISISPNAGQVLSRWDSSLVADKLNALCMHHKHFRIHTHNGDWVLDQPKYPPNKEKPMYNGHRADFHRVIYEYAMSLGIPIQLGRRVASYHEDDIEGKAWVVTDEGEIFKGDLVVGADGVRSKARKLVLGYDDKPKSSGYAVYRAWFDAEAAGITTDPLTREFVANGDTHTGWLGPDVHFLVATCKGGKEISWVCTHRDEANIEESWSLPGKIDDVLKILEGWDPRCRAIVERTPSCVDWKLVSRDPLPTWITASARTCLLGDAAHPFLPTSIQGCSQAIEDGCALATCLALSHADPTVSPLQKVPTALKTYQKLRYERVKEAQKKGEQVRDMWHKADWTKVRENPESIKLPREDWLMRHDCERYIRRQWVRASVEGCVMKREWLACGPESDEFMYQDMPPTPPAEDTMKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6T5</accession>
    <name>U4L6T5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6T5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="153" mass="17477" checksum="20CD845BB0F86492" modified="2013-12-11" version="1">MTTPQITQTTNQQSPHRVSVQMKQSIQGKRKRGEPTLLEPHQLNMKDILQAVGLKLDDIESFSLRFSAHKVGDRVADPQSAARRLNTPSCGEHAWLNAVNKAIGKWNMTPAPQRFAGHIIIFRLVSATQSIMRFEFFENEIVHYGGWYEEEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6U8</accession>
    <name>U4L6U8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935682">
        <property type="protein sequence ID" value="CCX12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6U8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3512" checksum="A3DD26B88D17F11C" modified="2013-12-11" version="1">MMHRQLVAGITEMKSRLFRNFKSGATLECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7X5</accession>
    <name>U4L7X5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7X5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7628" checksum="639D2794CE55558C" modified="2013-12-11" version="1">MSRITQIETTPEDVIEVSRTSNESGPYIYAKRDQVFKNFGDFEALIMPEWGLDLSIGKYIFFREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8W9</accession>
    <name>U4L8W9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8W9"/>
    <dbReference type="STRING" id="1076935.U4L8W9"/>
    <dbReference type="ESTHER" id="pyrom-u4l8w9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWPQFDY"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF11">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="12"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX14335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="479" mass="52037" checksum="56210DE08225819B" modified="2013-12-11" version="1">MPTTSTLNHAGLGKLTGLLQDDVVSFRGIKYASLQSRFAASEPTFPATPAKEDATKFGPEPLQNLGACAVEWFLIGGECPTEPGVEQDWSGLEGLTLNITAPKNIPAEKKLPVLIFIHGGAFLHGAASWPQYSLTPLVASSISTSNPIIAVSINYRTNVFGFLEHPSLAPNRGINDQKHALDWIYHNISGFGGDHENMTILGQSAGGASVGFHLEAGTAGVKRAVMMSGDPGIRPAVPPEVHRDTFEKVCAALSLNPESAIQELENMSPRDLYKKLPMNLLYLPSLPLPSGTGKPLQAIMVGDSKHDGGILLPPTTVDAKAVVEHFEQLPESFLALYGLKAEDDSDAAKQKLCNIFSDWVFYMPAVSRAMESKIPTYLYHFNVLNEWDGVWKGQSNHILDVAYLFGNYPELKDKAVSKDMQEAVVRFVNGDAPWSPREVKVFGSETDERTRAAAVWKIAEEAGGWDRVRGVVMSLLATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L962</accession>
    <name>U4L962_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Probable glucose transporter rco-3 acc. no. Q92253</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_09699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L962"/>
    <dbReference type="STRING" id="1076935.U4L962"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GCYRIPV"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
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        <location>
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        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="298"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="429"/>
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        <location>
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            <end position="461"/>
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        <location>
            <begin position="21"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX10106.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="512" mass="55916" checksum="76D9C907DAFFC3D7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9J1</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="2">CBS 100304</strain>
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        <source>
            <dbReference type="EMBL" id="CCX15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="50" mass="5779" checksum="86E770E9409428F6" modified="2013-12-11" version="1">MVFRFCIQPLATPLQLPSNDFESSSQPAYDNRNDWCPLSFVFFPCYKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAK3</accession>
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        <submittedName>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="27332" checksum="45D0680B51EFCA34" modified="2013-12-11" version="1">MLRSRRPPIPRPLSRPSHRAPLRLYTTPVRREANSTRNALPATYFHPNTPRRLKSTDNSQPPDERTLALGKTIRILQERMPTLLQSPLPTEILSPSIRLHLFPRTHPMLPAVSGRVAYIAALWTAPIAWGKLPGGSTRLEVVSERMMVGEKLRVRWKAVEEQGNKEFAGIFEFEFDEKGRIKKHVIENMEDDEGEVAGVITVTEWLIRKAKGVQTQGEGQLAWHCSRVDRNRGRRDQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAS7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Similar to F-box only protein 21 acc. no. Q5R5S1</fullName>
        </submittedName>
    </protein>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16523.1"/>
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    <dbReference type="eggNOG" id="ENOG502QS7Z">
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    </dbReference>
    <dbReference type="OMA" id="LLWRHHC"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
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        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="603" mass="68382" checksum="2DF59D0FFA02DB88" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAW2</accession>
    <name>U4LAW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAW2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="15813" checksum="F32960F0F70C127C" modified="2013-12-11" version="1">MSPPFLHFRPLATPLTRISEFIFIDTHEDLAQYHAHTSVTRTFERVILLFEHCGKWYGHRKHNVTRRHEPETVFKVYGALICVSFSALINFETSSQSSVDIRCHVRDQSHRTSLISTFLYHKSNMPNFHSYRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAY2</accession>
    <name>U4LAY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Receptor-interacting serine/threonine-protein kinase 4 acc. no. P57078</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936202">
        <property type="protein sequence ID" value="CCX15570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAY2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="18909" checksum="9F12137B314591CA" modified="2013-12-11" version="1">MIGRSRDCGSKINSAALNQTPLEIAVTEGHESIIRLLLERDDVTCHDVRTSLAGIFSKEIPLLAAVVYRGNEAIGRLLVEQNGININQGPHTALISAIDGMEDSADPKDFDILYFLLEKGADANLAGLREDTLLHVAVLSPYCGEMVQMSTHEISKVERHYHMPWKRDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAZ7</accession>
    <name>U4LAZ7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAZ7"/>
    <dbReference type="STRING" id="1076935.U4LAZ7"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NPHGGKE"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="171"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="316"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="463"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="637"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="826"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="986"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX15585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125970" checksum="CFAB991E993BD141" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB00</accession>
    <name>U4LB00_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_06928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB00"/>
    <dbReference type="STRING" id="1076935.U4LB00"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSHCKHT"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="548"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX07339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="832" mass="92432" checksum="8356151E50D9C025" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB89</accession>
    <name>U4LB89_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Negative regulator of mitosis acc. no. P24686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LB89"/>
    <dbReference type="eggNOG" id="KOG1858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000217">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="246"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1751"/>
            <end position="1830"/>
        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1944" mass="215610" checksum="019C27D6C8652CF3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCY7</accession>
    <name>U4LCY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935395">
        <property type="protein sequence ID" value="CCX29969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCY7"/>
    <dbReference type="OrthoDB" id="5356024at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="163" mass="18798" checksum="0ECFF1559BAAF6E8" modified="2013-12-11" version="1">MWADDELTLIVVLANLLSAIWTYFVIVFSFDQQSAGYKFIHRELAWYALWYSCQTYAFLVSTTNLSIAVYISLRVRDGLKERFKTTGTTRRIAWALIILLLAAAVMVACFIPWRMTLWDVELGDGESVERMEKIVGKAMETLGGRVDCQWDPRGRCRWVEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDG5</accession>
    <name>U4LDG5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDG5"/>
    <dbReference type="STRING" id="1076935.U4LDG5"/>
    <dbReference type="eggNOG" id="ENOG502SDD8">
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    </dbReference>
    <dbReference type="OMA" id="GTFSRCF"/>
    <dbReference type="OrthoDB" id="2103031at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="23148" checksum="257C296EDA982DAD" modified="2013-12-11" version="1">MWPFSSDDDKKGDNWSHISEEARAYLENEAPRKPSRNQFSSDGTPAPDAKPFDPTEFSNYGKKYADIWANYKPLDMVNAEGRTPSMAIHDVYESYNNRRTLIGRAALENCVFEQLALNECWNPGMIQKFSGCKEENRVFDNCYKSQQNFLRTLGYKNDINRDPEVDDKIQMHADKLYREQIEKEKKLEANSEAGKPLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE56</accession>
    <name>U4LE56_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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</entry>
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                <person name="Gabaldon T."/>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF26">
        <property type="entry name" value="AROM POLYPEPTIDE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="3">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="319" mass="35153" checksum="AE902BF29FB1B666" modified="2013-12-11" version="1">MGGALDARITRSDFTTHDHIASDDDSAQLTLPQTHQACPRLKFFIFGNNIAHSLSPTLHNTGFKELGLPHHYQIHETVAVDDGVREIMQRDDFGGASVTFPHKLQIGKYLESESRVAKLIGAVNTVCVRYGKDGRKELVGDNTDWLGIKSCIEVSWPTSKVDARAAVVVGAGGAARAACYALQELGIKTLYLINRTRSKAEELEKDFPTLEFVHYSSYTEFPEKVHPAPSIIVACVPADDFVEDDIPVGLFDDVENGVLVEMAYRPLVTALMKVAGRFTGWKVTRGVDVLKEQAYHQFFMWTGRKAPTAIMAAAVDVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFI2</accession>
    <name>U4LFI2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Peroxisomal adenine nucleotide transporter 1 acc. no. Q75A82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_09972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935539">
        <property type="protein sequence ID" value="CCX10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFI2"/>
    <dbReference type="STRING" id="1076935.U4LFI2"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLEMINT"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="256"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="381" mass="40629" checksum="78ADE780CBEAB822" modified="2013-12-11" version="1">MGAQSKPTLPPWGYAVAGATGAVLANAVVYPLDIVKTKLQVQVKRKPTVNGHANGTANGTANGTTNGHASSDEKTSSDEKTSSDEASEATAGTLTSPAASDEEEHYTSTLHALQAIFSKTGVAGLYSGMLGSLLGVASTNFAYFYWYTFVRSWYLRRTKASTLSTASELCLGAIAGALAQLFTIPVAVVTTRQQTRPLGAPHVGLLDTAKEVIAEDGISGLWRGLKASLVLVVNPAITYGSYQRFKDLLFPGKTRLSAGESFLLGALSKMCATCATQPLIVAKVGLQSKPPPVRKGKAFKSFGEVMRFIIENEGPLGLFKGIGPQILKGLIVQGLLMMTKERLELSFVLMFQGIRKMQQRKIAERAKLLVEQTARDVVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFK0</accession>
    <name>U4LFK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFK0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8668" checksum="DD9B12A94EB08CC6" modified="2013-12-11" version="1">MRHPTAHFIPPERLGRQIWLETHPKPQKFLYASTFSDGFHIMLSPSVDCLQEDQHVTSTHLPTVDDLECGFGLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFS7</accession>
    <name>U4LFS7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Charged multivesicular body protein 5 acc. no. Q6DD52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFS7"/>
    <dbReference type="STRING" id="1076935.U4LFS7"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="263" mass="29467" checksum="96A50CE738D585BF" modified="2013-12-11" version="1">MNRLFGSKSTAPKPTLQGAITNLDTRIESIDVQLAKINAELQTYQQRIVKMRDGPGKTALKQKALKVLQRRKMYETQKDQLEQQSWNMQQAGMMQDNLKSRCHFSTFSFFVLLPLLLPLHSGAATFSKVGAICWAGLVLMRPKRRFTDVMITVDAMKTTNKELKKQYGKVDIDKIEKMQDEMADLMDIGNDIQESISRSYDLPEEVDEAELDAELEALGEEVELGGGWEAESSTAIPSFLEDTSVPTFLDEVPASAGKVKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFW8</accession>
    <name>U4LFW8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFW8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="43942" checksum="3F713F4FCF70A65A" modified="2013-12-11" version="1">MRTKVYNPSYDKQKIVDNCKYLFGDDIDPVVPMEPQYDEIVEEQEQSDNGYSYSYRSVQKTYTYVRAVVLDRTHSDTSMLSAAGSRQRALSYSSPTKGTVYLTSNDATNDSTGMQWAMVNLRQLTTELTKDRVAQEVLHNKLKEGVEEKLKCVTAGTDLDDIFKEGLRQQLYQRARASFKRKQEKRKNEIARKMQDMLDTLDDEDEDDDEASMDQILLRVQRPSKNTTSQNNIDWCGEHVSNMIKDCQMKFREELKQQKELTKKFEEIEIAIQKAKDVANQKLLGVQLEHEGVKKIYDETIEGMKQDHAHSNAEKEAFTRDLKEELGAKVQALEKACSSVEKEKGFRKKPEDALDVLHETEMERKQGLAEFKAELQRNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV4</accession>
    <name>U4LGV4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGV4"/>
    <dbReference type="OrthoDB" id="5367262at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="28890" checksum="AADB23C192284EB9" modified="2013-12-11" version="1">MVLTTGQLRELERQQYYLRDPIDIDFVTSFVLQQQALHRQSDPQISETSGNGRGHARYGTHQDQRDAHKYSSPKQRLRTSSPQKATAGRRAGGHLPVTHSPDDMAHVHRKRRRGARSRDSSLLEFAHKDTDIRDFTNTRLASNDDIRELSPAGFTENVEERVDGRRTKNFEKRARHKMKDVPAKSPKKKTSKKYPSPKKAASRKRKKGEVSVPNKSDALIEGFSAENIKSGRITKWACIITTREKRITGSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGW8</accession>
    <name>U4LGW8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Iron-sulfur cluster insertion protein ErpA acc. no. A0KNY6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGW8"/>
    <dbReference type="STRING" id="1076935.U4LGW8"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHGFQYT"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="50"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="162" mass="17672" checksum="7D9FE62E1C8D97C5" modified="2013-12-11" version="1">MNPLRPLLRSIPRRTLRLSVPHARPFHLSRPALGLAITNPQTDPETGATMMLDLTPRAISRLVAIREKDNNPNLALRLTVESGGCHGFQYTIGLSEKIDKEEDVVFMDEDSGAKVVLDVPSLELLKGSTVDYTKELIGSQFKVLNPAATSSCGCGTSFDIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHT7</accession>
    <name>U4LHT7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Zinc-type alcohol dehydrogenase-like protein C1773.06c acc. no. O94564</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHT7"/>
    <dbReference type="STRING" id="1076935.U4LHT7"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REYGVYP"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="350" mass="37578" checksum="56BD2A545FE5E1A7" modified="2013-12-11" version="1">MSTPTSTTAWVHKTTIKPTEKFIETLQKQDLPLPTLGPKDVLVRLHAASFNYRDILIPRDQYPFPVNWPLVPMSDGAGEIVAVGPQVKSFAAGDNVMTVFNQEHQAGRHSIVSATSGLGGALHGVLREYAVFPEYGVMKSPKGWTHEQAATLPCAAVTAWNALKDIKAGQSVLVQGTGGVSLFALQFAKAMGAFVVATTSSKAKEEQVKALGADVVINYNETPKWGEVAKKASPRGEGIDVVVEIGGTATLQESFRAVRMEGTIAIIGYRAGPTKDGEKEPGWGEILGSICQMRAIFVGSRAIAEEMVSAIEVAGLKPVVDPKTWTFDEAPQALDWFEQGRHVGKVVIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIA2</accession>
    <name>U4LIA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized FAD-linked oxidoreductase ygaK acc. no. Q796Y5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936416">
        <property type="protein sequence ID" value="CCX16444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIA2"/>
    <dbReference type="STRING" id="1076935.U4LIA2"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFYITSV"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="437" mass="46508" checksum="3991780A3972B90F" modified="2013-12-11" version="1">MQCSGVKHTKPSATKTSRAMQLIVVLQFLVPLAAAFNARRSSLTDCLNAASVPILLTFSPSWQDATKPFNLRLTVNPAVVTIPRTKAEVSPISTEIASGLSGNMVIDMVEFQEVSCDASSTIATVGSGVRLGNMATRLFQLGERGIPHGTCSGVGIGGHATLGGFGLDSRLWGLTLDTVTSIDAVLANGTAVTASSSQNRDLFWALRGAGPGFAVITSFKMKTFPATPVNVNWAYTYVYGTAQKAAKAYSIAQAFGQTSAPKELGYGIMFFPGNQFIVRGVYHGPKANMDRILAPLLAQLTGLNDGKAPKAVVNTQGWIASLTELDGTTLQTSVRGYDKHDTFYAKSISTKESAPLSLTALNSMFTYLYTNPAPPNTIKDEAVEISNPLWARLGYPLVILQKHQLREALCGGIPLAVLGNDEGQEALSLHVLSVHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIM5</accession>
    <name>U4LIM5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIM5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7574" checksum="E44BE7AAB5822230" modified="2013-12-11" version="1">MFLTAGPNEPHIQIVDVEYINAVMMRKTDLSKPQKNSNLERICENYGKRIFHKRELRILLLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIR0</accession>
    <name>U4LIR0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cell division control protein 45 homolog acc. no. O74113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIR0"/>
    <dbReference type="STRING" id="1076935.U4LIR0"/>
    <dbReference type="eggNOG" id="KOG2475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="820" mass="91244" checksum="2E0768A40C4202D1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ10</accession>
    <name>U4LJ10_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936505">
        <property type="protein sequence ID" value="CCX16729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ10"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="6150" checksum="8502200B464E2351" modified="2013-12-11" version="1">MKISLRRMEHISTFLYHSSPRLLEFPTHLPETRTRFQHGITRRCQGHLGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJP7</accession>
    <name>U4LJP7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935799">
        <property type="protein sequence ID" value="CCX32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJP7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7769" checksum="AE1823B81776C05D" modified="2013-12-11" version="1">MTIVSHSTCHFSLTPIFQSFGTVNFNEVRGYRTRIQVGGKRCWMAHNRLVTYVKIIDVTGEILEDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJW2</accession>
    <name>U4LJW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJW2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="10283" checksum="ADA574B4A7838CAA" modified="2013-12-11" version="1">MVHTTGTNTKKPDKFLQHVLYHLRLRRDRSQNHCSSRIWRPAESVISVMTGRGFWPFKDRILQDVFHHLRRDRPQNHKAWDPEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK27</accession>
    <name>U4LK27_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935776">
        <property type="protein sequence ID" value="CCX13051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="14" mass="1636" checksum="0F8AF9138F620170" modified="2013-12-11" version="1">MVHYPFIGKSSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKN0</accession>
    <name>U4LKN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Major intracellular serine protease acc. no. P11018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKN0"/>
    <dbReference type="eggNOG" id="ENOG502S098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HGHGTIM"/>
    <dbReference type="OrthoDB" id="5093543at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="4">
        <location>
            <begin position="63"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="361" mass="40398" checksum="7881A6AB196C3A9C" modified="2013-12-11" version="1">MSERCPNVKARVHVKQRSTRGPQTRVQKLNAKLNNWFENVESFRDFMANLEKELPKPVVKERHVRVAIIDDGVDIFSLSDNVRECLVGLQSFALSEKPNGGMFKAAINSEHGHGTIMACLVNMVCPQAKLYSARLGSPAKDGEFQITVESAVQAIRWAIAMEVHIISMSWTIPHQERPDPEGKPNIFTELEAAIKDAHRKGILMFCSSRDQEYESMHELEQLYPQKCKDAVICIDAAQDSGQRDQWACSDGQFFFPGNASRSRTIQDMQRKSKDTTNLEGSSVATAVAAGFAALILHCAEILLVKQPKVPDDKKLQNVEEHPEADAIRQALRKSENTARIFELGNRSGDNLSFVSFSKIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLJ3</accession>
    <name>U4LLJ3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLJ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="33495" checksum="0F0D7FC3C916565A" modified="2013-12-11" version="1">MSLNSSDNLHFDAVYCRPEYQHFYNLPSLISLSPPPRPSPLPTAPLVILFEIFLHLPTISDAANFSQTCHSIYDVWATYNSSISLQLIQKDPRVTYEGSPGVQEWPVLKFAQELSRVQQSGLREPEDALATAKRQLSNANEVRNIVAHLHPIFHAYRLRCKPWSNYIQRGRIYHHVTISLSHWDEQGWMMLVQGIYKLWIAWLKGTTRYLHQKASKTSPPAPGNPVVVATMLEYLTGLPRMDMEGFPKLPKGFEWEPVGKDKVILRRIAHDLVRVADEVARGVYVKAKEEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLK2</accession>
    <name>U4LLK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLK2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="131" mass="14988" checksum="F72F3297E5A6C0D5" modified="2013-12-11" version="1">MNEIIACNLGTCHRTSKCFDILGRNNYPPTQRFEKDSGRVKGISFVFLFVFVVFVFFGVVVVVVVEVVFVFYCYCFCFYGKLQRERRGIQSKGLGVFPISINFLSTNLIAMAGSIVIRCFDNMWSFSIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLY8</accession>
    <name>U4LLY8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLY8"/>
    <dbReference type="OrthoDB" id="10503946at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22961" checksum="5904422AA5D43032" modified="2013-12-11" version="1">MPRTSSISFLFSLLERTVALYIPLIQWLISFLIMISSSWAIFDYHKKYPTRPINPELILLLCSTVPYLLWFIQYLRRVYNAPSWYFICTDLGLVALYSAAAVLLGRRLWGIDNTPVIKDLRLLKGILGLVIGQGCFFCGTTMGRVCLVVEECRKQRRRKKRNRLAREAAQKERKWSEVTVGGASTTEELDWDGGLPELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM16</accession>
    <name>U4LM16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936020">
        <property type="protein sequence ID" value="CCX14560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM16"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="2100" checksum="ACEDA907AF8831A9" modified="2013-12-11" version="1">MVEFDCIPFGVKKIAWCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM56</accession>
    <name>U4LM56_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM56"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="3158" checksum="BD42541FA9231966" modified="2013-12-11" version="1">MYSRQLYLRCLDVLDISVPNLAWSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMF6</accession>
    <name>U4LMF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936151">
        <property type="protein sequence ID" value="CCX15239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMF6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651580" evidence="1">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="15532" checksum="5159B0B765F2C1FB" modified="2013-12-11" version="1">MNTKSLLFFFGLASSVPGILCDVNFIPVNVSRNEKTAVTLYRDRDYSGLIYYKSFPKNEDSECITLDGNSRKQTVSYTVGNGCCEFFEASKCEKYMFKARNEMKIDLEKNGKKIYSFRCLNYIRCEPNRARFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN51</accession>
    <name>U4LN51_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN51"/>
    <dbReference type="STRING" id="1076935.U4LN51"/>
    <dbReference type="eggNOG" id="KOG3050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YESIHES"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX15845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="382" mass="41996" checksum="DE7F4B63157C7A70" modified="2013-12-11" version="1">MASLISQHASTSGLQIALHPLALLTISDYITRHALRNNTGPVIGALLGSQNGREIAIEYAYEILLAPSTPEKPVVIDKTWFEKKLSLFKDTHPSADLLGWFTTTFLPTYEPTPDHASIHQELLSYNESLCLLMMNPSPSGSINGKLPIAIYESIHESADKLSFIPLNYTIETGEAEMIAMDFVAQGAGGAASLPMSAPAGDAGGKGKQVEKVVKEGEEMVQGSSQGQVLNAQSEELISQLTAKKNAITMLNSRIKLLLEYLKNPPQGIHNHQVLREIKALTHSRLQLLKPTDMKAFEQEKRAEESDSNLVVLLGAVTRCMEDVRVVQKKCAGIEAVFKNNKAMEDQRNMMDRQGPMDLGVGLGRGERNRRNVMSGAFERERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN86</accession>
    <name>U4LN86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN86"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8353" checksum="BDF526F81169B831" modified="2013-12-11" version="1">MRILQTSLLPRNDSCGSIPVYEGKGVEPNGFDTWFPPTRGWWENSKEQALLQKAKSYKCWKYDVKAGNCIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNL1</accession>
    <name>U4LNL1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNL1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="17196" checksum="B0C58D6DDC828C15" modified="2013-12-11" version="1">MSTGSNSSNSSNTSNTSNNSNSSDFSDSSDSPSSPDEQEDLDALLEDCETEQELHLPRLLRPYHNLRLLPPSAHSPHWVTLAIAPSSPNPFASQAPDPSMSFSSAAASQASVFAALGTGFSDFAHSMDGVIEPPMNLSPPRSTRTRMITKRWEWMIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNP4</accession>
    <name>U4LNP4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNP4"/>
    <dbReference type="OrthoDB" id="10284703at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="19254" checksum="73F1D19EEA8B469B" modified="2013-12-11" version="1">MSLNNISDVFNNLRSRDFTPDSFMAALTRSPSTPPALNQIIGFATDCSITLQRFFILLADRTMQILRHIYRYPRQTATSVFGVLQMESSFASSGPVAASIARSWQSSRGIVFDTLEKVSEKGAQAVATTATAVGLGASRVWGEAQEILNSPAKQWWGRYEVRNWWEGVKAAGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP08</accession>
    <name>U4LP08_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_02920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP08"/>
    <dbReference type="STRING" id="1076935.U4LP08"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TKYKQWK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF13">
        <property type="entry name" value="GB|AAF27103.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="419" mass="45638" checksum="33C5EBDFED5C372A" modified="2013-12-11" version="1">MSVPPATPVGVPTETATHRADSGGGSGPTGSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNARQRARANGDEEPVDLQALPHPRRRRREKKLMSLEEANLRFPVMKYKTWQATRHSQGLPTAGGIKTEPSSRAGSIRHVGAISVDTTPDIAIARNTPLPVSPVEKEVGTSSAEDKGNAPITTANDRDRAIEDSNSMAQKRMSDVSEISRAKSPDHSDEAPIIPSQSSPEDGKHDTDNESDEEEEEHPPVDPSLLKESGDTCAICLDTLEDDEDIRGLTCGHVFHSVCLDPWLTTRRACCPLCKKDYYTPKPRPEGEVEQGSRSSRTRRGEGSGSGRSRTGASGRTNGASGSGRGRDRQSGEGLVRAMFGGGGRRRERETTQQQGSSWVHLLPELGIPRRAILRRERAQAQDLEAQTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPF2</accession>
    <name>U4LPF2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502S38Y">
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    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="395" mass="43699" checksum="E479DCEA858DA16A" modified="2013-12-11" version="1">MESPVLYCKHTTSPSTSLPMIIPAKHTSTRSFDQKKPRSIAIPPRTAAILAATAIPSRRRTKRTKLSVTTTDLYGPRTPPSSTAFDDVAILDDADTESFTALSVRTAMEVLLSPPDCDEDFSSSFLSRTSSSSSCDSESSAPGLETDTESTCDSITSSWSSNTGRREVRKTASPTEECSSSHPLLSTPVASQDTAKKTEIQPDALTKRATRRHHLNLVSNLTASLKAAAKSFSSLTAITASLQSEDYLTRSLIITPRSTDERRPPVTHREPSPALRRYLNPWSTTHEELPTTGMVMMQTYTRNSPSRSSSKSRRSRSTREQEDENCVCAPIVKQREQRENSDFLRVVVLEMNMRRSGKLDVACQGRARYSLPARRGEGLRRRVGAQRWRVISGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPG1</accession>
    <name>U4LPG1_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_02057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPG1"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5118" checksum="D805B034A9FEBBEE" modified="2013-12-11" version="1">MVALRTVVGRHQQLTQFSSSPGSPGLTSTSAMGSPGRDGLPNEREHNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPN2</accession>
    <name>U4LPN2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Tumor susceptibility gene 101 protein acc. no. Q6IRE4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
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    <dbReference type="STRING" id="1076935.U4LPN2"/>
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    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="518"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="585" mass="63326" checksum="CF4B94311A0E5283" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQA0</accession>
    <name>U4LQA0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized amino-acid permease C1039.01 acc. no. Q9US40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936516">
        <property type="protein sequence ID" value="CCX34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQA0"/>
    <dbReference type="STRING" id="1076935.U4LQA0"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YCIGIGM"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Marcet-Houben M."/>
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        <source>
            <dbReference type="EMBL" id="CCX29686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7356" checksum="C8280E6BB01B00F2" modified="2013-12-11" version="1">MWSLHLNNYIRGITNMNHSTYDWALDPRTEVAKSKLAPKGVERETGNHVSVEFNLSVPLSFRNL</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <begin position="18"/>
            <end position="174"/>
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    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936527">
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652590" evidence="2">
        <location>
            <begin position="23"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="425" mass="42492" checksum="7449B27BBFDDB3AB" modified="2013-12-11" version="1" fragment="single">MKASAVIFLALASISAAQGTYGAPHGTDAVAPAPAPIQPAAIPSAPAAPVAPAAPKAVPHPSQDALAPQAFTEKVVNSLGQTPKIDTHSAVTKITQQLHDKGVACTRHLAEKVEELIKEACQKGLEQAAVVDYVMHNLPQEGQAPATPSGPSNQKVEQPVAPSAEDMHTAVEQPSAPATPSAPSAPSTEEATESPAQESSETPAGPSGTGAYGAHGSDVPVAPGAPAEGCSGADCAPSTAVSHDSPAPEEVKPAAETPATPEAPAAPAVPETPAAPEAPAAPAGGATYGKRNLDSGFDFGSLIDFAFKGYHQKRYAPAPGATHINEKGEECDESGKPIKQEVPVAPGAPAEGCSGADCHPAETKPAAEAPSAPATPKTHINEKGEECDESGKPIKPAEQAPAPEAPAAPAAPSAPATPKTHINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRW7</accession>
    <name>U4LRW7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRW7"/>
    <dbReference type="STRING" id="1076935.U4LRW7"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AENSSWW"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="757"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124193" checksum="EB90A7F696E26CD5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRX8</accession>
    <name>U4LRX8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_12360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRX8"/>
    <dbReference type="STRING" id="1076935.U4LRX8"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INVSYNC"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="101"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="548"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX32090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="669" mass="74003" checksum="1771B8068FB2FF45" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS15</accession>
    <name>U4LS15_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS15"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="1971" checksum="E22C4AABFEEFFBAC" modified="2013-12-11" version="1">MKSRSPTGWELLGDHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS32</accession>
    <name>U4LS32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS32"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="181" mass="20389" checksum="7793E869A229AE4C" modified="2013-12-11" version="1">MNESRQTIYPVDLYEMDGSSDQDEDKDKDEDKTEDRTEDVDHQQPSATQPEQHQESSSTSSDSDSNSVSSFSSFSDEDQQQQQQQQQQQQQQQQQQPLIIAIPALSNQESNLNPAPEVHEILPESLSPPVADNLDDESSGMDHTNNMESENLQGVIQDLNQETEPQAPQRTSAKRKAEDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS86</accession>
    <name>U4LS86_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS86"/>
    <dbReference type="STRING" id="1076935.U4LS86"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DSINMID"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="250" mass="28239" checksum="6B115F7BB03CE0B7" modified="2013-12-11" version="1">MKKRRNEPEADRRYLKILTGVLRHYATVLMQSDPKKLDLKALKEQRNLMRGINLRQNAGQLPLHSFISRKNTLVADYKRGAYLKDPESVGKPAGNPMSDPAGMDQMMNMLKGNMAMIVPQTLIMGWINAFFSGFVIMKLPFPLTIRFKTMLQSGIATRDLDVRWVSSLSWYFLNLFGLRSIFNYILGSDNSADQMSAQMQQMNPAAGASMFGPGQDPNKMFLAEAENLEVAGGTHEWVIEGVEDRVLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSA1</accession>
    <name>U4LSA1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="HF935733">
        <property type="protein sequence ID" value="CCX32220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSA1"/>
    <dbReference type="STRING" id="1076935.U4LSA1"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="176"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="453" mass="49791" checksum="0521900698D0E654" modified="2013-12-11" version="1">MSARPENIGIKAIDIYFPNQCVEQSELEKFDGVSAGKYTIGLGQTKMAFCDDREDIYSMALTVTQNLIEKYNIDVNTIGRLEVGTETLLDKSKSVKSVLMKLFGENTNVEGVDSVNACYGGTNALFNAINWVESSAWDGRNALVVCGDIALYAKGAARPTGGAGAVAMLIGPDAPLVFEPGKRGSYMAHAYDFYKPDLTSEYPYVDGHFSIRCYTEAVDACYKAYNKRAAALSAETNGVNGAAPEGIDRFDYMLFHAPTCKLVAKSYARLLYNDFINNPSSAQFADVPAELRDIAYEASLSDRNIEKTFVGLSKKRFSERVQPSIELPTNCGNMYTASLYSGLTGLLKNVDSDALQGKRVAIFSYGSGLASSMFSFTVKGSTKEFAEKMNLTERLAARNIVAPEVYDAMCELRHRAHGKKNYSPEGSVDTIVKGSYYLTSIDDMFRREYARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSC2</accession>
    <name>U4LSC2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized oxidoreductase YisS acc. no. P40332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSC2"/>
    <dbReference type="STRING" id="1076935.U4LSC2"/>
    <dbReference type="eggNOG" id="ENOG502QUH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFNAWMS"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="414" mass="45524" checksum="889C2B00E5E86816" modified="2013-12-11" version="1">MAPVNVLMVGTGEYTTGWVGSGASGSDKKVGVVGLSLFDLRRRRKVGDLSMVGTNGSKFPAIRQHLEKNIKNVYNGLDVGFISFPEDGQVDPKAYIAAIDKLSPGDAITIFTPDTTHYDIALYAIQRKIHVLITKPAVKTLEDHYSLLSEARKHGVFVFIEHHKRFDPAYSDAAAKAKVIGDFNYFYSYMSQPKSQLETFKAWAGKDSDISYYLNSHHVDINSVLAPGWVPTSVTASGSKGTATSLGCVEGTEDTITLLTNWTKLEDRTKVATGVYTASWTAPQRAGVHSNQYFHYMASAGEIRANQAKRGYDITDDSQSGISWVNPFYMRYAPDEDGNFGGQTGYGYVSFEKFVDACNRINAGQATPEDFDKRGLPTLLNTAVTTAILEAGRISLDEKRTVEIREEHGRLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTE1</accession>
    <name>U4LTE1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCON_13631</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 100304</strain>
            <tissue evidence="24">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTE1"/>
    <dbReference type="STRING" id="1076935.U4LTE1"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PPYDFND"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCX32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="24802" checksum="42141C86F59A9C05" modified="2013-12-11" version="1">MNSVRTCASRVVRNVSTVRPVTVAVRNSSTDAGEYKSPFTGASAHRTTKIPDFSKYKSSSSAKGNQVFGYFMVGTMGALSAAGAKATVQDFLVNMSASADVLAMAKVEVDLSSIPEGKNVIIKWRGKPVFIRHRTPDEIEEANKVKIETLRDPQADADRVKNPEWLVMLGICTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYDFPEDGKLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUH7</accession>
    <name>U4LUH7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUH7"/>
    <dbReference type="STRING" id="1076935.U4LUH7"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF30">
        <property type="entry name" value="F-BOX DNA HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="10">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1131" mass="129649" checksum="8FD6B25A60D6C159" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUN6</accession>
    <name>U4LUN6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Probable thiol methyltransferase 2 acc. no. Q6AWU6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUN6"/>
    <dbReference type="STRING" id="1076935.U4LUN6"/>
    <dbReference type="eggNOG" id="ENOG502QS1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVHWNLL"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="31161" checksum="0DC32D6DEB09B93B" modified="2013-12-11" version="1">MLPLLPTFLLRLNPSNPSNHPTTHLFLPPYHTMAIPRSDEKLDYDNLFDTAEDILRPSEARELFRKHFLSLCASPALVDLMAQKETLPIFQAHSSATPKRALVPGCDRGYDALLFAQHGYETVGVEISGSAVREAKKWTGQQIAAGQKTLSPMGFILADFFEDEWLKVLGIGKEQFDLVYDYAFLVAMNPTMRKKWAKRMADHITPGSGLLVCLEYPLFRPPESGGPPHGITSSDYDALLRENFEKEMHYMPKRTHKVGEGSDMVSVWRRKEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUP9</accession>
    <name>U4LUP9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Pre-mRNA-splicing factor cef1 acc. no. Q4WHG0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_02144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUP9"/>
    <dbReference type="STRING" id="1076935.U4LUP9"/>
    <dbReference type="eggNOG" id="KOG0050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KMGMAGE"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="769" mass="85457" checksum="9827E1BB315FC054" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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</entry>
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            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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        </source>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="9473" checksum="2477EA8E15D09A45" modified="2013-12-11" version="1">MRVGPRRWNGQFFLPFLLLFEEMERRKAEQEEIEQKAKQKGEAERRARNEKWERERWALWWNTRTYQLMILMIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW55</accession>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10781" checksum="B2D14FBEE33BF3B4" modified="2013-12-11" version="1">MHIQITLLRYPPTVVPDSSFDLDALNNRPRLAHASATSPRLNIVSRAISRNSGYQTGQFKSQFSFHFQRFRTFSDNQLGAWGTLTSGCRSHKPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWA1</accession>
    <name>U4LWA1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936082">
        <property type="protein sequence ID" value="CCX33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWA1"/>
    <dbReference type="OrthoDB" id="10311608at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652457" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8682" checksum="350E9757071809BF" modified="2013-12-11" version="1">MKIVIIIPLLYAATISAIGFIIPDRPVASDSPYAIMKAQIKGGECYWAKCGDTCDGGFIPKQFRLCDPRSGPTQRYCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWL6</accession>
    <name>U4LWL6_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWL6"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="10883" checksum="8113798696B2BE93" modified="2013-12-11" version="1">MQGLNRTRLIVKQPGYFYNPATNLRYTLERIYKKIPISISLGLPSHYKRTYMLKHNFVLYPPEHLRRSAHTAFSRPGHDNSFHGRAPHTSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWX8</accession>
    <name>U4LWX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to ankyrin [Exophiala dermatitidis NIH/UT8656] acc. no. EHY59712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWX8"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="18221" checksum="F4D3E87ECFFE2F37" modified="2013-12-11" version="1">MDDISNPFADGWILSCAVEECSQNIKRLYMALGKLELAKNSGRGAEMIERLKWPLKKEEYEKDMQTLRRLLRIFEFSLNLSSCELLSKTSAQLEANQQKLLTAIHAFEEATGSVSKELLQRSNDITEALGLYRSNPSSMLRGYRRCLEDYKKSEKTFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXT5</accession>
    <name>U4LXT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXT5"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="327"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="43669" checksum="433F3F12E20B165D" modified="2013-12-11" version="1">MTKHLYNPVLDKQQIIENYKYLFGEDIDPVVLTLVVDFTHSNGQIYNYGCKAVVVKRALTSLISASESGRTPCEEYSLGKNGVVCLITECRMHFSFIENANIALSNLHRMTALLVRQKMAKQDTINKEILKEVDEKLQRLTVNVEDNAVKSELGRLLYDRICASTTRKEQKRKAEITAKAQELLDTLEDDEDDEGETAMDRLLLRVQQPSGNTSNAPNDIDWRGECVSNILRDCQKKFREKLREQKEDLTAKFEAETKQKIDGIKDEQALKDAEKEAVIRDLTEKLDAETLSRELACSEAERERGFREKLEDALDVLRQTENQRRQELLGVRQQSDRHRERIRELEQEKSGSTVVGDAEGNDHDTVTDASVYTPTGSTVDGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU01</accession>
    <name>U4KU01_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935198">
        <property type="protein sequence ID" value="CCX04322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU01"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="589" mass="62799" checksum="729A3C4AD44D3D0A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUK8</accession>
    <name>U4KUK8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUK8"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="18490" checksum="1B6CFECEB208C441" modified="2013-12-11" version="1">MSFKQEFDGYKNDAGIGIYFGYNNFLNVSQPIDNTFEWIPGGIHSQLHIILSLVAPTRFLPLGITDDCYDPKGPSLVFNASMRPYLPILEFLESLESDDFFDNPKFSFRSFTESPESPGSPDTNQEELMDKRPYRRQQPASRHPFRVVASQILSHVRPPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVL6</accession>
    <name>U4KVL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01195</name>
        <name evidence="1" type="ORF">PCON_04144</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <strain evidence="1">CBS100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935222">
        <property type="protein sequence ID" value="CCX04981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF936105">
        <property type="protein sequence ID" value="CCX14969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVL6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
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    <accession>U4KVW5</accession>
    <name>U4KVW5_PYROM</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        </source>
    </reference>
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            <end position="56"/>
        </location>
    </feature>
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            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="15319" checksum="A1E6C2A2505140A4" modified="2013-12-11" version="1">MSSATATRKISTRQRISEGLREIKSKVLESKQRLTESLKPRTRSRSTRTSLSSFRAGSSVLVTSTTAAVNSDIIESSPMEHNSASITKNKGRESISFPDGNSSLENKIIHSTAIRGRMSYTIATITKTIADFRAYLCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWY3</accession>
    <name>U4KWY3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_05358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4KWY3"/>
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    </dbReference>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="12">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="308"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
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            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX05771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="688" mass="74089" checksum="10777A7564834EEA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY00</accession>
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        <submittedName>
            <fullName evidence="9">Similar to UDP-N-acetylglucosamine transporter yea4 acc. no. O74750</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">PCON_02267</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SCL35B1-4/HUT1"/>
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    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UAA"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="439" mass="47276" checksum="03A1CFA0B6C4896F" modified="2013-12-11" version="1">MAKPRRTPKKPSATTTTPSTSSSSPSTTSTSSPSTTSLSTPVSEAPDAMSSADLHNGSVSPRESKTQEIDARPHLEAAAGISKAPEVPPTIYGVLAQCTVPAWMSTVVMVSLIFGGCCSNVFALEAIIKQEPHAGHLITFAQFALVALEGLIYHFDPSGPYFLKPRQIPLRRWAVQIALFWLVSIMNNQAFAYNISVPVHIILRSGGSMTTLLVGWCWGKRYSRVQVISVVILTVGCVLSALADGEGMGKTEASMSRFLTGLGILFVAQLLSAIMGLYIEATYTKYGNNYREGLFYTHALGLPLFLVFSNSIKEQFLKLLSTPPLSPLPFLPPVLNRIITALPHKVLYLILNALTQYVCVRGVNILGSVSSALTVTIVLNIRKLVSLWLSIWLFGNNLSGGVMAGAGTVFVGGLVYGLESQRQRAMAKRAAKNSAKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY32</accession>
    <name>U4KY32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Increased recombination centers protein 6 acc. no. C5M2I3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY32"/>
    <dbReference type="STRING" id="1076935.U4KY32"/>
    <dbReference type="eggNOG" id="ENOG502RTVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EALMMRM"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="351" mass="37802" checksum="5E5AEA0318F76A39" modified="2013-12-11" version="1">MPEEISNPRRILLVGTKKSGKLTVLKALTGSLPITLTTGAPHAGLSHELRLETPYYKATVPIWVDEIPEPAEAPAAAIPTSSLPAATDGSVLNTDEKIPEDETSIYFKTLAAEAKASETYPGTSTETLEAAAAADADAKKTPETAGTPAEEQETLETWTSNYCSPAAKEVLSVLGSIIITFRLPSVASIQSLGKIVKSMGRDWDGVLLAVSLTKPSEAMEDLCQQHGFELIEFDAKGRNEYGETQGMVRVKEALEANDWVGGDGELGGLSDEEEGDEVDGVGLVGDEMQREMLGLRQAITGGDEGEEEDEREVEKLEEVMQRLVMLRDLGPEVSKEQRQRMAKEALRGLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY42</accession>
    <name>U4KY42_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Ras-like GTP-binding protein rhoA acc. no. Q22038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY42"/>
    <dbReference type="STRING" id="1076935.U4KY42"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEKWIQE"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="210" mass="23184" checksum="DEAAE5244E89D36B" modified="2013-12-11" version="1">MPKRTSSKRSGASASGLPVRRKLVIVGDGACGKTCLLIRFSSNTFDPDAYVPTVFENYVKDITHSNGTKVELTLWDTAGQEDYDRLRPLSYPDSDVVLISFAVDSPDSLNNVYEKWIQEVKHFCPNIPILLVAMKRDLRSDQGAVRRLQQREGRGPVTMEEGQKAARELQCSSYVECSSKTGEGVYEVFERASTLGAGPTKKKGSSCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY92</accession>
    <name>U4KY92_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY92"/>
    <dbReference type="STRING" id="1076935.U4KY92"/>
    <dbReference type="eggNOG" id="ENOG502RH41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYWTGPA"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="576" mass="65006" checksum="B5C2982DA1B7D107" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY95</accession>
    <name>U4KY95_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_06533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935324">
        <property type="protein sequence ID" value="CCX06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY95"/>
    <dbReference type="STRING" id="1076935.U4KY95"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9298" checksum="AC145017CE2F7B72" modified="2013-12-11" version="1">MSAPINPRPMLQALIDKPILVRLKWGSTEYKGTLVSVDSYMNLQLSGTEEFVDGSSTGSLGQVLIRCNNVLWISAAPKEDVAMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYG6</accession>
    <name>U4KYG6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYG6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="11799" checksum="7F8605D3CD88579D" modified="2013-12-11" version="1">MSLGTVGPSPTNNNGYRFAPNYLRGPHHHATTPPTSLIKAEPPPVLSLRYCVKTQASCSSCITRPALVHADSEVHPGMWSNIPLAEARPTIQQTSLTAHQTKIELRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYW8</accession>
    <name>U4KYW8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYW8"/>
    <dbReference type="STRING" id="1076935.U4KYW8"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="350" mass="37542" checksum="6AFFF2F9AAD690AA" modified="2013-12-11" version="1">MSSIRLSSALRLVSRRTVSSSAKRLVLPTAAALPRVQIPVQQCRSSSHSPFSATAGPPRKKVTINTLRNLYNAKTPIAMVTAHDFPSGLAADLAGVDMVLVGDSLAMVALGMEDTNQLTLDAMLHHCQAVSRGVKGAFIVGDLPMGSYEISPEHAIKSSIRLIQEGRVHAVKLEGGAEMAPTISRLTSLGIPVLGHVGLTPQRASSLGGFRVQGKTLSSAQKLLADALAIQEAGCLGMVMEAVPAEIAEIVTSKLNIPTIGIGAGVGCSGQVLVQVDMLGYYPEGRFMPKFVKLYGDMFKVAKEGIEGYMKEVKERSYPEKQHTYPMGKDETLEAFRAWVKDQDVKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L028</accession>
    <name>U4L028_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C1494.08c acc. no. O60082</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935247">
        <property type="protein sequence ID" value="CCX05334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L028"/>
    <dbReference type="STRING" id="1076935.U4L028"/>
    <dbReference type="eggNOG" id="ENOG502R9IN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNNDAHN"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="71"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="404" mass="44781" checksum="DDFC4E059DFC349A" modified="2013-12-11" version="1">MQTFGTRPTSIHTLGSPFVQPPPLPESPTFFSPPILSPALSRSSSSSSGFSNASRNLRRHLLIRDLGIDNLLVPKNRRAKFDLELQLHDLNNVPLVSGHAYIKWHIEGNTRADCRGRTKREPIKDHKVLWNYTTKVPTLRITIGKGNMLSDLNLIMEVHQEYGDRERILLGIVRVNLAEYAGLEKETRRYLMQDSKINSTVKVGIEMHQIGGDTNFQAPQLKGAQVFAGIAGIINEQRETDDSRNMHLQYTKSRETGATQDMYRRTLAASWQLIPGELNADECIEDIFAGGDGWSGSSGGRRGKPKSVRLSEASDSDSISQLSVTASTPTTSTHSDKPQLLSVTTIEPATLNGKKKGYALSVMTARSRTSSGKTNKSQGEIDEFEARDDLVSWRMPSHRLRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4L090</accession>
    <name>U4L090_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="13" mass="1386" checksum="DC57469D894E32CD" modified="2013-12-11" version="1">MVSTLAVLGIREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L169</accession>
    <name>U4L169_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L169"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="126" mass="14343" checksum="AC1BF5DF92FC9C1E" modified="2013-12-11" version="1">MIDFNPDEILLNEIPIHHIKKGQRERGFEVVETGESTSSEDEIGDSEEEAGEWLFSEDETSDGEEEWDVIKGDGLDDEDDMELDEEGGEQEEDSQGEEDIEGEGKSKEDDYSGDEGQRNRKRLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L198</accession>
    <name>U4L198_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L198"/>
    <dbReference type="STRING" id="1076935.U4L198"/>
    <dbReference type="eggNOG" id="KOG1594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="35807" checksum="8A8DD8DBF74B0439" modified="2013-12-11" version="1">MVDRANKPGALSVSKVIGRDSGVVEIKDDRVKISLPSGESAEVLLYGATVISWVADGAERLFLSKEAKLDGTKAVRGGVPLVFPVFGKATEGPCAKLPQHGFARISKWDVLGWNVLGDEEREPSVQVDFVLDSHNLTVEWPLKPEANDQPYQPYAFSLMYSVILKRNSLETKLRVSNEEPEESEEPKNDRAFDFNALFHTYLRVADVTKLGVTGLKGVSYKDKVEGGAEATEERDELTVASEVDRVYANVPGTVVVKEGDRTLYTVERQNLEDVVVWNPWTGAAKIGDFSPDDGYMNMLCVEAGAVSSWHKLMPGDSWEGGVTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1F2</accession>
    <name>U4L1F2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1F2"/>
    <dbReference type="OrthoDB" id="10372823at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="315" mass="36413" checksum="DABE31E3FF48796B" modified="2013-12-11" version="1">MESQNTPPSVDENAWFDQGMILDYFQNLQEENTQLRKELMATKAQEDLNIMERYNEINDLNTAQRQLQAEIAETEKLKKTIERSLWTPQIPDIELKKEDGVSDHEYRTVIKHMGELLGRFGEIERQFYEIKKGFHDTTKDLADNLALISKEYFAVYQRLEQVESSKAVTAAVTDAALAELQSGTAALMLNEDGYFSRIMRLKLTPPGIIEVFDETMYRNYVYIDCNRISTIETFEDIMNKAWPADVVSVWPPIKCFPRPSIQWPHDVSSVKHLALKPCGPFSNDPKNNFYEITSIVYRTEETEDVLSSFDIQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1Y7</accession>
    <name>U4L1Y7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1Y7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="27352" checksum="2523943680A69A04" modified="2013-12-11" version="1">MERSCSIPISWWPFENPGPKFVWCCFEKSRLHLHEGISMDYRLHQISMPPNATDHAAFQAFRQQYYSFIGIWRRYLSLKVLTCIYFVELRVHENDRVEIPESQKTKPLRELLDSLHKHRSGLYHYSDNLDTIPFTSKELRRRFHSREGQGGHYIAKVPGRIPEVTFHDSGIAEYGLHFVHGLRFAGVLLIVLIWVFLSLGLGVAVDMRTDTGIGAGVGGGILAALAVFLSFLQILLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2F2</accession>
    <name>U4L2F2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Nucleoporin nup44 acc. no. O42963</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2F2"/>
    <dbReference type="STRING" id="1076935.U4L2F2"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMQTRLH"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="471" mass="51397" checksum="D9D5194D7D4CF3AF" modified="2013-12-11" version="1">MSLFGQPAGGNSFFGTPTTQQPASTGIFGSTAAQPATGGGLFGQPAQPATGGGLFGQQPQQQQPQTGMFGQPAQQQQSTGLFGQPTAQPATGGGLFGQQPQQQQQTGMFGQPAQQQQSTGLFGQPAQQQQTGTGLFGQTTTTSGGGLFGQQQQQPQQQTGLFGQPAQQPQQQTGLFGSTFGQQPQQQTGLFGQPAQQQQPQQQIGAFGAFGGLGSASMMQQPQQVNAVIEKIAKVNNSWDANHPDYAFRYYFYNSIGKERASQYQKPPGDDNDAWEKAWAERPNDGCVPVRANGFKDLDLRVKSQEKQVLLFRTELHNIQEKLNAIQSRHDLTTSIKLEDCRRRHVALARRALSLAAKVQVLKNRGYALQPEEEMLKKRLEGLAKLVQDPAAAGRMNEIWARMMVVQEKARAMEESMGKVEIVWDENQLQTAGRLLQSNFDGLGYLTKEVLAIEKSFAEWEELHKTRNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2N0</accession>
    <name>U4L2N0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Acyl-CoA-binding domain-containing protein 4 acc. no. Q9MA55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2N0"/>
    <dbReference type="STRING" id="1076935.U4L2N0"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMSEVLC"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="549"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="725" mass="81104" checksum="D6700B4F7D2A7D7E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Q4</accession>
    <name>U4L2Q4_PYROM</name>
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        <submittedName>
            <fullName evidence="5">Similar to Receptor-interacting serine/threonine-protein kinase 4 acc. no. Q9ERK0</fullName>
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    </protein>
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        <name evidence="5" type="ORF">PCON_06110</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L2Q4"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACAGHEN"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    <dbReference type="PANTHER" id="PTHR10039">
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    </dbReference>
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        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
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    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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            <begin position="844"/>
            <end position="995"/>
        </location>
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        <location>
            <begin position="1478"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1512"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1540"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1573"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX06523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1639" mass="184958" checksum="1360AC2C63FBBFD7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L328</accession>
    <name>U4L328_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_10466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SW1V">
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    </dbReference>
    <dbReference type="OrthoDB" id="10298204at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="729" mass="83314" checksum="0D27EE888F35C9C4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L431</accession>
    <name>U4L431_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX04815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L431"/>
    <dbReference type="OrthoDB" id="5372266at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="353" mass="39712" checksum="A97B1BEF501A80FF" modified="2013-12-11" version="1">MALNGTITRQTLGSRLSHALFALSIVFEIAATIQSSTVLLDGDAYIKKHGLEAGQLYLLNEHVLKVTFFAHLMYYLAECVLKAAYLAFYADLYSRIQTKRRIAIWIATFIWATSYLAALLLIFTYCLPFEQNWRPDGKNPHCPVLFNVPAFFVLAGANILSDIAILVVPLLIIGAMRLGRNEKNALILVFSIGMMSIAASVIRAGVVGHRFVTANHTWDTVWVWMLWSHAEMFFGVIAFTLPSFRYILLRGMNKMQTTTQKLGYGSKVSTNRSGRNQSQKLPDESIDMDTTTTTSLKGHAEREGVLVQTTVTLKEESRAYQLASESQTNLTAVEDARQRAVPYEWRIDSERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L483</accession>
    <name>U4L483_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L483"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="141" mass="16660" checksum="84B2528484DDA17B" modified="2013-12-11" version="1">MDEGEEEQSDCRINNHLNPRMTNMISIDYIKRKRQPTKPRDDDDFANLLREGYQKDYDTPVLHLGNQPFVFYTKLTYVDRETEKRIVLTNGTNVCMRRPNAPNNQLQYGKILFLFTHEDNGNVKIFVVLQPALHHHEQREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4B7</accession>
    <name>U4L4B7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4B7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="10186" checksum="5B0C8BA4456ADA13" modified="2013-12-11" version="1">MHMRSCHSGGRIVSSYAHCERVSRVSRVKVLHSQPFQLPTNAKRATRYLRNLTKTDNVQQGATRYDSIRKCLMHPPPTLTFALKPPLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4P4</accession>
    <name>U4L4P4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_11063</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935621">
        <property type="protein sequence ID" value="CCX11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4P4"/>
    <dbReference type="STRING" id="1076935.U4L4P4"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GLQTYFD"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="302" mass="34868" checksum="40EB14692325E701" modified="2013-12-11" version="1">MPPAAAAKPVTYDVQERVLCFHGPMLYEAKVLEVRKPEDKKEQPEYKVHYKGWKNTWDEFVPADRLRKINEENLRMQKELNDNSKPSKPKPAAATKAKPSKAGSEDPIIPARGQKRGREIEIEKEEDYMKRHDVKIAIPDVLKAYLVDDWENVTKNQQLVPLPKELNVVTILEKYRAATPKKRPGSAEADIFDEIVAGLKLYFDKSLGTILLYRFERQQFLEIRKEHPNKEPSEIYGAEHLLRLCVSMPELLAHTNMDSQAMGKLRDHIEEFVKFLAKNPEQYIASPYESASPRYIDLSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4U7</accession>
    <name>U4L4U7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cell cycle control protein cwf14 acc. no. O74772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4U7"/>
    <dbReference type="STRING" id="1076935.U4L4U7"/>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="151" mass="17508" checksum="EE59DE5EF5044F55" modified="2013-12-11" version="1">MPPERHARGYSRKAPPDGFDDIEKTLLEFANRMKDAETAPHEGKKKNEATWDIFRISHQRSKYIYDLYYETNAISKQLYDWLLKNKYADANLIAKWKKQGYEKLCCMRCIQAKEHNFNTTCICRVPRARLNDESSGIQCTHCGCSGCASCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5S0</accession>
    <name>U4L5S0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_07360</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5S0"/>
    <dbReference type="STRING" id="1076935.U4L5S0"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="3"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="222"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX07771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="306" mass="32095" checksum="B60A534633B46FCE" modified="2013-12-11" version="1">MSILIIGSLNTDLITVTPRMPAAGETLTASSFHTAPGGKGANQAVACARLSLPPTKVSMIGSVGRDSFASPLLSELEDSGVDVARVTSHTSEPTGSAVIVVDGSNGENRILIHTGANGTVTPECFPETEDWNAVVMQLEIPVPTVLSILSAAKTQGVKTIFNPAPAVPLPEECWKDVDWCIVNETEAAILTAVEQNVLDSKEGVETAGKELLRRGCGAVVVTLGARGAYWCAEDEEGWVETGVKKEDVVDSTGAGDTFVGALAVGVVEGKKREECVDFARRAAGRAVRKRGAMAGVPWRREVEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5Z1</accession>
    <name>U4L5Z1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5Z1"/>
    <dbReference type="STRING" id="1076935.U4L5Z1"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTNDMAS"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="80"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21722" checksum="25E31F3591E64465" modified="2013-12-11" version="1">MVSSTSSPSLNPATGLPTGWVVKYSTSKVLPYYYYSPTNTSQWEPPRDCDHEILKHFMAANYSLPGPLTTDEKGDELRREGRIRCAHLLVKHRMSRRASSWKEAEITRLPSEANNMILQFERRIRAGEMSLGDLAVSESDCSSARRRGDLGWFGRNEMQREFEDAAFSLEPGEMSHPIETVSGMHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L620</accession>
    <name>U4L620_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_11351</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L620"/>
    <dbReference type="STRING" id="1076935.U4L620"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="212"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="413"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="630"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="671" mass="71477" checksum="B22753F8735F63E7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L652</accession>
    <name>U4L652_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935256">
        <property type="protein sequence ID" value="CCX05500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L652"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13526" checksum="E8BCE856D8F26092" modified="2013-12-11" version="1">MFTNITIMPTDPRDPLNSLSTDSVRVYSLYSQSEVSANAAIVVRRRGLVFSAPKLKLAKQDKEAKETKEAEETKDEQDQEQEQKLNEGENKENEVNNKRGVQYYCAGNGVEDLMIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6K3</accession>
    <name>U4L6K3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935776">
        <property type="protein sequence ID" value="CCX13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6K3"/>
    <dbReference type="OrthoDB" id="10494072at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8053" checksum="031E9B7D96BE1A95" modified="2013-12-11" version="1">MSSSGNPNYEDPNFPHPKYENAQINAHMENLKKREQAQALSDATGEGTEGFGSKGERMKEQQQKEAAAKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6P1</accession>
    <name>U4L6P1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_12204</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6P1"/>
    <dbReference type="STRING" id="1076935.U4L6P1"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="9"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="213"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="381" mass="43435" checksum="09F5E79F5D1058A3" modified="2013-12-11" version="1">MSEERILDDISHRRFNPLTGSWILVSPHRTKRPWQGAQEEPAKSTLPAYDPSCFLCPNNPRATGDVMPDYKSTYIFINDYSAVKEDQPSYSTPPAESSSDLSPLLLQAEAVKGRCYVITFSPSHNLTLADLPQASLLSIIETWTALYTSHLPQDHKYFNTSKSAELGIVSPKEQYTYLQLFENKGSAMGCSNPHPHGQAWCTSSLPTEISTELHNMREYKEKHGRGLLVDYVTLELEKRERIVIENSTWVALCPWWAIWPFELLVLPKREVASLPGLTDEEKGDLAQMLSQCTKRYDNLFKTSFPYSMGIHQAPLDAKEEVEQCYHLHLHFYPPLLRSATVRKFLVGYELLAEPQRDITPEQAALRLRGLDGERTYREEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L780</accession>
    <name>U4L780_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to E3 ubiquitin-protein ligase RNF216 acc. no. P58283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="HF935699">
        <property type="protein sequence ID" value="CCX12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L780"/>
    <dbReference type="STRING" id="1076935.U4L780"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="223"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="618" mass="66415" checksum="07F14C065FCD9378" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAC6</accession>
    <name>U4LAC6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">PCON_02341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAC6"/>
    <dbReference type="STRING" id="1076935.U4LAC6"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WFPGTSG"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX15882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="26613" checksum="CEBC1B38CDF84036" modified="2013-12-11" version="1">MAAPVENNDQLVLSEDPNHPANLICSLCRNFYTHGWVTGTGGGISIRERCDAHDRIFIAPSGVQKERLQPDNMFVMDFPTKSYLRKPLNLKPSACTPLFMAAFEKRGAGACIHTHSQAAVLCTLLTKGRVWRIGGIEQIKAIPKGYGQEGYMGFFDTLEIPIIENTAHEEDLKDSLEAAMEEFPNTCAILVRRHGVYVWGDTVWKAKTQCESLDYLFELGVKMVQLGLDPAAPIAAVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAE7</accession>
    <name>U4LAE7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAE7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20943" checksum="32F128392F9180B1" modified="2013-12-11" version="1">MTKERISDFGEASDLRNEKDGDNIDDGIYEEIKDALASDVHSSFDGTLDHSLNSSRVSLSSLNSSRSSKPHGSPIPSHKPEFRYQRRFAIIATPPQPRHFTLSHIQYFTPEVYDSLAIWLHKHCVRYRRIACLGRGVTKEEAEGVPVIVVEVWGDVVELSKILGRDQQMVGKIPREVQGVEFVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAI1</accession>
    <name>U4LAI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to MutS protein homolog 1 acc. no. O13921</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAI1"/>
    <dbReference type="STRING" id="1076935.U4LAI1"/>
    <dbReference type="eggNOG" id="ENOG502QUUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTWIMRR"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="860"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="983" mass="109939" checksum="887EC482C18ED245" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAS5</accession>
    <name>U4LAS5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Exosome complex component rrp40 acc. no. O13903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAS5"/>
    <dbReference type="STRING" id="1076935.U4LAS5"/>
    <dbReference type="eggNOG" id="KOG1004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SYMAFPN"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="29749" checksum="A603028889A42334" modified="2013-12-11" version="1">MPLLLPGDPVIAPASQKKQQLKLGPGLTHTPPDNIVAHKAGELIIDTRKNVIWVEGNGRRYTPTHADPIIVTVLRGSADAYICAIPSSSSPAPSSVQATLPHLAFPNATKKTRPILAPGAVVYARVSLANKHMDPELECFDAESGKAMGFGELKGGMVFSVSLGMARRLLGDGNRMRGVWKREQKTARKEREEAGMTDAGDAEKEEEWEGTGAEVLEELGRLISFECAVGRNGKVWVEAEDVKSTLMVGRCLAAAESLGAEETKDMVRREVRALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAW5</accession>
    <name>U4LAW5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_01922</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="HF936198">
        <property type="protein sequence ID" value="CCX15555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAW5"/>
    <dbReference type="STRING" id="1076935.U4LAW5"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFETLCH"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX15555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="466" mass="49576" checksum="E29DCD6CDCEF4E98" modified="2013-12-11" version="1">MLDRTRATVEGFLLDHRRGFSTSATADAWGVDQVTQPDITDKETVLTLARISADAYTEVEHTGDWLEVGTPYNLTNDFGWQADGLRGHIFSNQDNTTVIIGLKGNSAAVFDGADTTTNDKINDNLLFSCCCARVSYFWSTKELTAENRHYRASLQLYYNVTQLYPDAQIWVVGHSLGGAVSSLIGQTYGLPVVAFEAPGEALAAGRLGLPLPPGMARQNDASGVYHFGHTADPIYMGACNGPHQSECTYDVVSDKGWRMGLGYHRIQGVIKDVIEAYDEVPKCTYDPGCADCFNWKFTEGNDTSTTTTGAPVSPTPTGTMTATTTCATPGWWGCMDGSTTTTGSDISGTGTVTSTSQLRPTGLASSTSSGNATTTCTHFGWFGNCLDPSPYPTITKTKHHTSITITDTRVSGTDTAAPTETESCRHYGWFGGCLDPEWPPATVSASTSASGSAAPGSSSTAVVKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB81</accession>
    <name>U4LB81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Molybdopterin synthase catalytic subunit acc. no. Q1DQS9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936503">
        <property type="protein sequence ID" value="CCX16713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB81"/>
    <dbReference type="STRING" id="1076935.U4LB81"/>
    <dbReference type="eggNOG" id="KOG3307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKREEFG"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="209" mass="22932" checksum="6B6685D3081CA526" modified="2013-12-11" version="1">MPQPENHTCCSLALSTEASLAPSQPMESTPTSAPCCAGPTHLPPPTASVPGALYENATFSNAAENIHIRLTYDCLSLSTMADLICSPSAGAIVLFLGTTWDTFSDLPVMTLSYSCYMPLCLRMLTTIAREIKKEHNLYGIAFIHRLGDVKVGEETVHIAVSSKHRKEAWLAGEEALEEVKKHAEIWKREVFQDGSAWRSNRDGERGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBE8</accession>
    <name>U4LBE8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Sulfate permease 2 acc. no. P23622</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBE8"/>
    <dbReference type="STRING" id="1076935.U4LBE8"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHNRWTK"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="588"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="804" mass="87396" checksum="D2270F572FB4C28A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBK9</accession>
    <name>U4LBK9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935363">
        <property type="protein sequence ID" value="CCX07697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBK9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9641" checksum="27DD7B420FD063E9" modified="2013-12-11" version="1">MVPIFVVDLSIDLSTQEPSWWEETDPAKATQVPVLRQQPDKTFIGSRECGTLVSWHGSRKATRRRGLMDGDKDVHGISCEDEGDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBR5</accession>
    <name>U4LBR5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to NASP-related protein sim3 acc. no. Q9USQ4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935371">
        <property type="protein sequence ID" value="CCX07747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBR5"/>
    <dbReference type="STRING" id="1076935.U4LBR5"/>
    <dbReference type="eggNOG" id="KOG4563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IAECHYK"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="4">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="412" mass="45121" checksum="85C5D4225A5D286B" modified="2013-12-11" version="1">MSAANDEKRNELEALKARAVKAYATKDFPQSVDIYGEACQLQSEIQGEDNPANAQLLYLYGRALYRVAIDKNDVLGAPTDKADKEKEQSAKGRRDLASVSEEPEEKADKLAQAKKAAGLFQFHGDGEYDESDEEDEDEEGGEGEDDDDDMAAAWSVLDLARVMFEKQIAADETDKKWTNEEAKEVKTMLADVYDLLGEVSLESENFFQATKDFDSSLTLKEELCPLESNLISEAHFKMSLALEYSSTGEGISKDDEKKLRNAAAEHIDKAIDSCKARKAIEEAARELADKGKGKAAASEASKDKQIDEIDEIIAELEQRAEDLRNPPPPTQLEQDEQLQGLLGQILGEGKDPMLAKQALEQAMAGANDLSGMVRKKAKPAKEEGSASSSSAKRKLDDAEEEGADKKAKVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBZ8</accession>
    <name>U4LBZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Helicase-like transcription factor acc. no. Q14527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_03686</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936535">
        <property type="protein sequence ID" value="CCX16895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LBZ8"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="780"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1112"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1185"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1438"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1438"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1485"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1533" mass="168402" checksum="B9D47E2BC9F02138" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCK2</accession>
    <name>U4LCK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCK2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="210" mass="22606" checksum="3F936095AC129B21" modified="2013-12-11" version="1">MSSSSSPFAASASSQDTAPASPALASDSPVQVPATPVRQLSQIKTLKLASIPINRTAVFNELSAVERAAALDYFQFFYPDVERNIIVAHIRRQCHKLKSEKKRQANRALALAVGVAADAALASATATSTGSPSADAVGSDVSLLLFLPQPQMDHQLLLFLPWTSWMLQAPPSDPEEPEMDDEDAIFTKESLKSAIEMRRREADEAVAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCL5</accession>
    <name>U4LCL5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935358">
        <property type="protein sequence ID" value="CCX29814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCL5"/>
    <dbReference type="STRING" id="1076935.U4LCL5"/>
    <dbReference type="eggNOG" id="ENOG502QR55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAKEYRM"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="270" mass="29972" checksum="A8D617D812B54D68" modified="2013-12-11" version="1">MTSALKITLPEFSQALSRYDTLITSITHPKPPFLTDLDPWRRHILPGLIASRTPPYMTKDELYKLMECKLKRGKSRPLLPLILRNAPSLVHTCTQTAFSTPDLSTSLQHLCKLTGVGPATAGYILAAQRPEEAVVFSDEGFRWVVCGGDWGANMKYTKEEYLTLVEGVKEVQKRLGEGVKMEEVERVGFVLGREAGGDKGTKPGRKRKVEDEEEQAEEKGRGKKGRISKGKELKEGGKEDTTGDTGKETKEQTVLNTSGRILRSRKKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCV9</accession>
    <name>U4LCV9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Proteasome activator complex subunit 4 acc. no. Q14997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LCV9"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECTQLVP"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="373"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1353"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1858"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="909"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX29934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1945" mass="219529" checksum="0999DFFC034F0E87" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDU0</accession>
    <name>U4LDU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Probable proteasome subunit alpha type-2 acc. no. Q8X077</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDU0"/>
    <dbReference type="STRING" id="1076935.U4LDU0"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="273" mass="29721" checksum="5BA9B6CEDFC0B457" modified="2013-12-11" version="1">MADRYSFSLTTFSPRYALSLFCFSHPRILSLELRNGLRSSADSFIIEYALNAVNQATNGVVLATEKKSSNALTNSSSLEKIAYITPDIGMVYSGMGPDFRVLVDKARKVSHTNYKRIYNEYPPTRILVQDVAKVMQEATQSGGVRPYGVSLLVAGWDDKPAGTGKGGPALYQVDPSGSYFPWKATAIGKSATSAKTFLEKRYSEGLELEDAIHIALLTLKETIEGEMSGETIEIGIVGPPADNLLGYDGVEGASGPRFRKLSPQEVDDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE11</accession>
    <name>U4LE11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Zinc finger protein 501 acc. no. Q5RF70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE11"/>
    <dbReference type="STRING" id="1076935.U4LE11"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ALDHWAP"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="268" mass="31436" checksum="35F993C3E1EA9427" modified="2013-12-11" version="1">MAWYCDPCDRYFVSRHSLQQHYDNSVLHYDNYICSYCDDEFHSQYALNNHVDSVHEYPYHCQECSTMFRTQYGLDEHVEEEHPEPEWWCHDCDRQFMNENNLRMHLNSRIHRGTNITCPWCKNTYATATGLTTHLESGSCRDGINRETIYNTIRRHDQGGAFTHKMIEGPNGQRFNQTVTATERSWNGRFYECPLCTRECRTLPALNQHLNSPAHQQNLYHCPKCNKQAKTLAALINHIESGSCGIMTFDRVQKNIQGIVTGKRMIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE71</accession>
    <name>U4LE71_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935468">
        <property type="protein sequence ID" value="CCX09523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE71"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="16" mass="1624" checksum="E303FB2A06E00E27" modified="2013-12-11" version="1">MANYQALSAGTAEPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF96</accession>
    <name>U4LF96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized protein C56F8.02 acc. no. Q10250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935855">
        <property type="protein sequence ID" value="CCX13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF96"/>
    <dbReference type="STRING" id="1076935.U4LF96"/>
    <dbReference type="eggNOG" id="KOG3628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4523419at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="350"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="437" mass="46738" checksum="396910956621B628" modified="2013-12-11" version="1">MDNPTLIAQLSALDAELEEGDITQKGYQKRRTLLLSQYGLGSDSESGSARSSIPSAGASGPPGPPGSSEPLVSPLAPSQASAPLASPSYPQFPHYANDGGSYQAEMAPGMSATLGSYGSQDSPASPQSGDTSSGSFLQSAVPPHMRSNSKGRNQRNSFHGIEEPMASPQHTSNFSGASSSILSAPSAHSAPPVHSAPPPPGSAPGFNFTQHYTPEFHHYDMPAPGSTSQQALRSNTMNDQIPLFSDFTAQAYENEPATRGSLQIHRPESDYIPHSQQPQMARYSTAADGLGFSPTAAVAQTMLNTSDLPQPAVTNTLMPLEPREVPFAVYDPHNTNIAMSRFENIHTVLRHRARTIPKQQAYVVLDNKGKEQQVCSWEKLSLRAEKVAQVIREKSGLYRGDRIALVYRDAELIDFAVALLGCFIAGVVAVPINDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFC5</accession>
    <name>U4LFC5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13277</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFC5"/>
    <dbReference type="STRING" id="1076935.U4LFC5"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="242" mass="26941" checksum="76C791BAE455B9FE" modified="2013-12-11" version="1">MAPTKTDKYSVIIPTYNERKNLPVITWLLARTFTQHNLNWELIIVDDASPDGTQDIAKQLIKVYGSDKILLKPRAGKLGLGTAYVHGLQFVTGNFVIIMDADFSHHPKFIADFIALQKSHDYDIVTGTRYAGDGGVYGWDLKRKLVSRGANLFATVMLRPGVSDLTGSFRLYKKQVLDHVISETKSKGYTFQMEMMVRARAAGYSVGEVPISFVDRIYGDSKLGGDEIVEYAKGVLGLWVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFH9</accession>
    <name>U4LFH9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to extracellular serine-threonine rich protein [Aspergillus oryzae RIB40] acc. no. XP_001820093</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935538">
        <property type="protein sequence ID" value="CCX10373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFH9"/>
    <dbReference type="STRING" id="1076935.U4LFH9"/>
    <dbReference type="eggNOG" id="ENOG502S73X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651407" evidence="2">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="196" mass="20196" checksum="94BEA22EE4B26FE3" modified="2013-12-11" version="1">MRFANVFAAGAALVAAVIAPVFAAETTTNQANPISAPLAQVKLTAGKPFTIEWLPTAGNQVTLVLRKGKDVKSLDTLEVIAKDLPNNGAFIWVPSPQLKGDVDYAIQIWSKNPDTSNYSAQFVIDSNGPGIQGTTVVPSTTRAVATPTRSGAVPTYTGAETTDIPTAAAASAPNGVGKIQVGGSWVFGVIAAAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGP4</accession>
    <name>U4LGP4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to GPI anchored serine-threonine rich protein [Aspergillus fumigatus Af293] acc. no. XP_750113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935575">
        <property type="protein sequence ID" value="CCX10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGP4"/>
    <dbReference type="eggNOG" id="ENOG502S56Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITWQAKP"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="257" mass="26566" checksum="272683B01CFFE824" modified="2013-12-11" version="1">MRYSLFAVAAAIISSVQALTAPVGQPEGNPIHTPGLNDLVIAGKPYTITWTPTSEGPISLVLLRGPSENVKPIATIVEGIPNSGSYSWTPSTALEDDVTHYGIQLIQDKTGFYQYSTQFGVSNKKEPVSSSYIAPPAPISSTYATPSESAKPIQPVEESPVPEAPKPTIVYSTHTSTITACDCEESKIPVSSVVVPVPAPTGSGVPPTYNNNTQPGYSAPVPSATQPAGVPTFTGAANKLASGSMAVVAAGLVIALF</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX15563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="4212" checksum="E9A049C5110141E1" modified="2013-12-11" version="1">MEQELRISNPSLRYKVAGKVISVLKEYYKPDKEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGZ4</accession>
    <name>U4LGZ4_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Similar to Enhancer of yellow 2 transcription factor acc. no. B0WG73</fullName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <begin position="32"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="15268" checksum="9D078B56D963C803" modified="2013-12-11" version="1">MYILSLPTSGDVAQRATEVTEEERETPATEISDSDEDEGEENEPEPESESKLELESTDEDEPLESHLLQLLQESGWSENLRNLCQERLRDPTANIGNYEELRNSVDTQAKEMVPEAVKAEMVKKIAVLLRGMCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH21</accession>
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        <submittedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="19" mass="2023" checksum="6D829BF767CDDC20" modified="2013-12-11" version="1">MDVVSDGWKTTACVEVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHD9</accession>
    <name>U4LHD9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30942.1"/>
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    </dbReference>
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            <end position="161"/>
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        <location>
            <begin position="449"/>
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        <location>
            <begin position="102"/>
            <end position="114"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="550" mass="62805" checksum="415BB72260CB6356" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHL8</accession>
    <name>U4LHL8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09843</name>
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    <organism evidence="2 3">
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHL8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="127" mass="14127" checksum="777C30123D160B44" modified="2013-12-11" version="1">MPFFHGVTKVTVKRIPRFCNDASKIGLGMACTYCRAVGTARICSGIIYSFTRHPPPLFVLKNPPFYVLFTKFSSGIGQSRIAAWDSLGTPPRQSPHPTFARSQNSPSKTRERRAIHGSVKASMRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHR4</accession>
    <name>U4LHR4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHR4"/>
    <dbReference type="STRING" id="1076935.U4LHR4"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="6"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="774"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="944" mass="103711" checksum="EE211CC5CCA80FA0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHX5</accession>
    <name>U4LHX5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_10022</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHX5"/>
    <dbReference type="STRING" id="1076935.U4LHX5"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EFQFRPM"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="269"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="981"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1156" mass="128073" checksum="36F8A983309DCBE2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI27</accession>
    <name>U4LI27_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI27"/>
    <dbReference type="STRING" id="1076935.U4LI27"/>
    <dbReference type="OMA" id="HYVEQGG"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="256" mass="28571" checksum="9A1A06440309AEF9" modified="2013-12-11" version="1">MPRLGDERVFAGHNDGEPRTNRQPRNLSAIMSKPTVIGIFSDLDASVMGSYTRDLWMKLDEAADHRQIYSCNEARDLLEDEANRPQAVLLADPEVMQNLEFGQILVEYTQNGGTTIMYGPFPALMESGKFDQWMRETWGILWSYAGGGTCDVYINPYADGLKKMYGNEGGDHLDNGISVHDKFTLLQGVAEKDKIYQIKDVLSAKGKTFSLDEINDESQTAVAFRKIGHGWLGWMGSVNPKHWALIDVTLGMCGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIF2</accession>
    <name>U4LIF2_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to Late secretory pathway protein AVL9 acc. no. Q12500</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_11713</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935678">
        <property type="protein sequence ID" value="CCX12119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIF2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AVL9/DENND6" evidence="2">
        <location>
            <begin position="11"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120121" checksum="53076B0E0B9CE141" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ43</accession>
    <name>U4LJ43_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ43"/>
    <dbReference type="STRING" id="1076935.U4LJ43"/>
    <dbReference type="eggNOG" id="KOG1688">
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    </dbReference>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="187" mass="21915" checksum="7ADC4A4089E9BD50" modified="2013-12-11" version="1">MDSVPPDQTFPAAVSAQTSRITRAYQTYIDKSVPYTTYRWIGTTVLLLAFMARIFLAQGWYIVCYTLGIYLLNLFLAFLTPKFDPSLEQDDEMEGGGMPALPTKNDEEFRPFIRRLPEFKFWHNSTRAIAVSILATFFDACDIPVFWPVLVIYWIILFTLTMRRQIQHMIKYRYVPFTFGKTRYTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJE6</accession>
    <name>U4LJE6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJE6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="29" mass="3565" checksum="8BF4E478F7A41B0F" modified="2013-12-11" version="1">MCRMISKSDEMTWRSKFDTSSREAHQFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJR2</accession>
    <name>U4LJR2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJR2"/>
    <dbReference type="STRING" id="1076935.U4LJR2"/>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX29620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="575" mass="63290" checksum="69166C77A1D26459" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJV3</accession>
    <name>U4LJV3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJV3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="6155" checksum="2A2063A378AFEF98" modified="2013-12-11" version="1">MACRNRRIITFTHPRITWTVEVADWLVVGRPVKLRPLYSSSTPHLGKYELGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJY6</accession>
    <name>U4LJY6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJY6"/>
    <dbReference type="STRING" id="1076935.U4LJY6"/>
    <dbReference type="eggNOG" id="KOG1421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWGHCVF"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="790"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="880"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113417" checksum="ABD1DEB47CC9091F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK87</accession>
    <name>U4LK87_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to DNA repair protein rad16 acc. no. P36617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_12059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK87"/>
    <dbReference type="STRING" id="1076935.U4LK87"/>
    <dbReference type="eggNOG" id="KOG0442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THILDIM"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="746"/>
            <end position="826"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX31982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="965" mass="107989" checksum="D2A38BD00979DBF5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL11</accession>
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    </gene>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="8099" checksum="FA54C6E7FABC7FF1" modified="2013-12-11" version="1">MAHRAGLCSLCSTPHECLCCRWFVSSYLKKSNLDCSKDRDKATRDRLLQQDIQHSMCSLVDCGLVIYCRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL32</accession>
    <name>U4LL32_PYROM</name>
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    </protein>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3597" checksum="1BD8D4C505BDBF41" modified="2013-12-11" version="1">MLFPITLAGTVQGRSFYCPHSTCVQHAGSISSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL95</accession>
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        </submittedName>
    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="CCX30135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="207" mass="24043" checksum="5219F5D9B7F648F0" modified="2013-12-11" version="1">MHRNNYTTAQGTRSGQVNDIAKSLNEASQKRIINNNQLSTISQLSESLLECQETINVLLTELGDHFGNTVRGKFGRKLKWPIKEPKVVSFIQKIGRYQQIFQQALQSNLVEVALRTEMTVNETSEVVKQVRNEQLDEQDARIMEATRNKINEVARWLSEFPFNTKHEESWEKHQDGTGNWLFEKEIYRQWGTSKPSAVWIHGDSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLI8</accession>
    <name>U4LLI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLI8"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="234" mass="25684" checksum="AD3F1E4BEECF7263" modified="2013-12-11" version="1">MLIPKSTSDYSLLRPSVPSDTAVNTAANWPERADLHNPVTYDDNYSIISCSAVIEDENGPVANAGRYSGTPQRDKESLPVSRTASIAPRSTLHSYEKRLCQSNEPIALILLEAFKNSAVAPDDPATSEISNDEYDTADEGPLTASKQLPHKKPARNPSIYKPPTYGPPPNGIPWIWLVVLKVLLIIVFVFALGSLEWYLIRHKSQTGFLDTAMSWDGAKSWNGTTSWNETIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLX4</accession>
    <name>U4LLX4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLX4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6569" checksum="23715CB6CA63E893" modified="2013-12-11" version="1">MSRVFVSLSHSSSPSETIPLGIPYTSVRNLCNFTTHLIQPQQSCCGSVETRMLEAGCGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM31</accession>
    <name>U4LM31_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936044">
        <property type="protein sequence ID" value="CCX14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM31"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4646" checksum="D93D8B39C29C76B7" modified="2013-12-11" version="1">MSSAPTLQLAQAHLFEARSLTPEWNVNMCVPYIKDPRHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMF1</accession>
    <name>U4LMF1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Choline dehydrogenase acc. no. Q2KB43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936136">
        <property type="protein sequence ID" value="CCX15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMF1"/>
    <dbReference type="STRING" id="1076935.U4LMF1"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWTPWLL"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651499" evidence="4">
        <location>
            <begin position="33"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="509"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="660" mass="72452" checksum="FB037AEBD818BF8F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMH4</accession>
    <name>U4LMH4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMH4"/>
    <dbReference type="STRING" id="1076935.U4LMH4"/>
    <dbReference type="OMA" id="APCNKGP"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="170" mass="17418" checksum="9DD7177EF9FE0A10" modified="2013-12-11" version="1">MSAIRPTTLLRTLQPLASRRCLSTTPLARKSIPDTIKNAAQTVDRAAANATLKGIEVGEKVASTMSHAAESVTGSASQAMGATKGATNEAMGTAKGAANESMGAAKGAAHKAEKMSEKKAGQFAGSAREMEGAAMGKKEEMKGAAKGTMEEMKGKAKGMAREMEGKVKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMI4</accession>
    <name>U4LMI4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Nephrocystin-3 acc. no. A0JM23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMI4"/>
    <dbReference type="STRING" id="1076935.U4LMI4"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DCHERAL"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DUF7779" evidence="5">
        <location>
            <begin position="429"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1208" mass="134806" checksum="B339CA62BC6E88C7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN08</accession>
    <name>U4LN08_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="283" mass="30868" checksum="83F15A14A93D14B4" modified="2013-12-11" version="1">MASLPAFPTDARELLMMILNPSPLVAITIALCIFTIPIFLHLFIFPSSSSSTLPTFLLLGPSSSGKTTITTSFASSPSETRTSQAALCLECDIPASLTKSSGFRSSNDPSMRGVAKFYLQDTPGHGKLRNKAIEMINKDTRGVVFVVDSGVQEEWTDAAEYLHDVLLKIQKLQDTQGNKREEFNVLVACNKSDLFTAKPAQGKEGIKQTLEREIAVVSATRRRGIVGAGEEESDEDQCLATDEDGKFKFESLQEFGIQVVFKSGSTIGDGWRQSMGEWLGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN47</accession>
    <name>U4LN47_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN47"/>
    <dbReference type="OrthoDB" id="10418261at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="25090" checksum="9FDFCBEBE56347AC" modified="2013-12-11" version="1">MASTEIMYRYFKELAGHSEELSELEEDPPVMPDIKEIELHNYQRSDGQGTPIIEQIRQALQERQIELLRLVHKVTHQSLFVHDRISELGEKQDLLIADRKSELRKWRKELRRKHIPQWIIDHIILEPKWKCEKQYHVLETMKNEFGWWLAELDRRRAGLTQQLAEVENEYLRRIEILAVRERGNKLLQLQMGPLEKLPDEKSWMFYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNU2</accession>
    <name>U4LNU2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to LIM domain kinase 1 acc. no. Q8IR79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNU2"/>
    <dbReference type="STRING" id="1076935.U4LNU2"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="416"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="891" mass="97101" checksum="A05D9CF8465E1E3B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ28</accession>
    <name>U4LQ28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ28"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652265" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4516" checksum="F24D7A3728869132" modified="2013-12-11" version="1">MKFSLATILFVFALVAITAPEPIVDGSGLEARQMKPNFTPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ97</accession>
    <name>U4LQ97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Dihydropyrimidinase acc. no. Q55DL0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ97"/>
    <dbReference type="STRING" id="1076935.U4LQ97"/>
    <dbReference type="eggNOG" id="ENOG502QQ9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGFKPYD"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="412"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX17451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="890" mass="96161" checksum="574AEF2BF60239B6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQA8</accession>
    <name>U4LQA8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQA8"/>
    <dbReference type="eggNOG" id="ENOG502T2KP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422587at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="35845" checksum="D4B5ACAC4CB55FBF" modified="2013-12-11" version="1">MSNAMKKLKLLQHHISAASVNSIPAGFPTPPASPVFHSGPTGYPTGYDHYQAHYYQPPPPPPQHQHHYYPRPDSRQHHQQYYSPPANQGHQAAMPGQVPGPCLLPGGFMVLTPSSSHDHLPSAPTRRAPRLTKDAVSAIGKDSRLARWERVLSYVREQRNTIAPGLLPSSGSPKSCPATLAGLAGSTSTSPASQAVGYRQDRKRRAEEMALIDLRCKELERLDRVEQDTRSLWSGGSGGTNGVDEFVWSEDEDDDVLPMPRGPEPVKVLPYEAQGMDRIREEQEEGVFAMDESRSGRWAGMPQICREGELEGGLGRLVGRRMSAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQY3</accession>
    <name>U4LQY3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQY3"/>
    <dbReference type="OrthoDB" id="10353446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651692" evidence="1">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="197" mass="22093" checksum="4FB25222A2E9E103" modified="2013-12-11" version="1">MRLTSLLVLYGALLAATAPITSDDNTLSARSAGQKETLWVWSSASKREATPKETSDFIKRGLKETLYVWSSAGKRDLAAVEKRGTKETLYVWASTGKRDISELEKRGMKETLWVWSSPGKRDLPSGNEIEKRVAEPGMKETLWVWSSPGKREATPDEVNELIKERDVEFVKRGTKETLYVWASAGKRDVAEANQSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRB5</accession>
    <name>U4LRB5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935358">
        <property type="protein sequence ID" value="CCX29816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRB5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6527" checksum="1AAC6D734D907D8B" modified="2013-12-11" version="1">MNNPDSLFPRDYGSRLHTTQGEQRPALTALTPSHPTTDPGEVYRLSELGTTEKETDPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRL5</accession>
    <name>U4LRL5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein psi1 acc. no. Q09912</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRL5"/>
    <dbReference type="STRING" id="1076935.U4LRL5"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FPDVINP"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="379" mass="40055" checksum="1357A5240AEFCD6D" modified="2013-12-11" version="1">MVREKKLYDTLGISPSASPDDIKKAYRKGALKYHPDKNPNAADKFKDISQAYEILSDPEKRKIYDQYGLEFLLRGGSAPPDAGPEGAGGFAGGFPGGGGGGFPGGSGGFPGGFPGFGGGGRGGGFSFTSGGGPQTFHYTPGNPNGIFESFRMGGGFDGLDDELLQGLFSGGSPLGGGRGGYGSRMNGRGNGNGGGGVPKKAEATVVEKNIGFTLEELFSGTRKKFKVKRKTFDREGRIQREDKDLEIVVKPGMKAGSKFKFSGVGDEVDGTKQDIHFVVVEKPHPVFTRVGDDLEIRVSIPLKEALTGWEKQVTTIDGKNIKVGHSGPTSPGWSDTFPGHGMPLPKDPSKRGDLIVKVDIVFPSSLSAEQKEQLKKILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSI3</accession>
    <name>U4LSI3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSI3"/>
    <dbReference type="STRING" id="1076935.U4LSI3"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTNQVCL"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="7">
        <location>
            <begin position="146"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="311" mass="32795" checksum="28BF4915182B5827" modified="2013-12-11" version="1">MSTAAPVLRRSTRNAAKRESPIVAEASAPAAKKAKTVTEKKAPAEKKAAAPKKAAAPKKAAAPKKAAAPKKAAAKKGDKKEDVTAEKTEKAEKTEKAEKTEKPADTKDEKPAETKEAEKPAEKEPAAPAVKSLEEGDALPEDLPTIQTHNGETTTLGALVKASEKGIVIFAYPKASTPGCTTQACAFRDSTASFKSHGYSIFGISGDLPGPNKNFFTKQNLTDIVLLCDPKYELHAKLGIKKGAKGTVRSVIVIKKEEEKAVIVKKGPATPANSVDMAAKACGFEVPKKVVEKAGEKEKADAKEGEAEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT29</accession>
    <name>U4LT29_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein alcS acc. no. Q24JP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT29"/>
    <dbReference type="STRING" id="1076935.U4LT29"/>
    <dbReference type="eggNOG" id="ENOG502S179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCATRTN"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="272" mass="29158" checksum="795D664B7794F768" modified="2013-12-11" version="1">MSAPITINDTETKWSQSRDDLSQHTARPTQSFPIEVLDKFDISKYNPTKSFGNPTPLALAGLVLCLTPLSAQLMGWRGADGSGSANNGAHFFCGGVLLLLGGILEFFLGNTFAFVVFGSYGGFFLSLGATLTPGFGALAPYTTDSGALNHAFYNSFGFFYLFTGLLSVVFLICSIRTNIVFVGIFLAYSIAFPLLAASDWAKGMGNEHLGHTLLVAGGAACFVVSMLGWYALLSSLLQSVDFPFDLPMGDLSNVILGKQQRKKLQEEKTKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTW3</accession>
    <name>U4LTW3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTW3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="153" mass="17903" checksum="7CC5E2A49991FA05" modified="2013-12-11" version="1">MSGDLPRINDVPLSDTVARFINYWPCVRPDRLPRGQGIPRPINLQPYTFRVLMSIHPTTFRRLRMLGDFKTLPAANLAASNYITPKAHSYFSFWKDDFGMLHIEPRMDKVNFRDPGYAMIWVEASNQRRITQNNVDLGVWDPNNPRRDGWDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU01</accession>
    <name>U4LU01_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Nuclear import protein MOG1 acc. no. P47123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_14300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU01"/>
    <dbReference type="STRING" id="1076935.U4LU01"/>
    <dbReference type="eggNOG" id="KOG3329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECSSAWM"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="207" mass="22578" checksum="16E390422FA70852" modified="2013-12-11" version="1">MPAAIPQIPTQTADLFGGNITAQIPQNFVDASRHRPVPDTQEVFVSGTYDTDISIVFDILCRVEGSDEEALAVHWEDVAVEEGRGQRLFNQEGVQVPGLPNVKAFQLTGTINKPSETTFTALLMTVIRLEAQDTDFVVTVNVPFLTPEQVAAEGMLAAPQFQGELSGVPGELLQAGLAIRDKILDTLRVVNWGLFVAGEEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU60</accession>
    <name>U4LU60_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Carboxymethylenebutenolidase homolog acc. no. Q8R1G2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU60"/>
    <dbReference type="STRING" id="1076935.U4LU60"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKHREAV"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="248" mass="27658" checksum="4DD2A86E4D739230" modified="2013-12-11" version="1">MGKELELHGLPVYTTGDGETVIVIITDPFGWNHPDARFLADTLARSTSATVWMPDFFSGDSLPAEQLALLTPPSGELSFFEKSASVLKRSQAFAPWLFAHREGVSWPIIERFFESAYNEKPLRPLIAAGYGWGGRYAALLTHREKWTTTSGTYKEGGFIHSAFVAHPILMTADELEKCERPVTMVLGDAEEVGGFKKLQAAAQKKGIKCELLEGAQQGFALHQGKSAMEKRYWEKSRDLAVEWAREYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUT4</accession>
    <name>U4LUT4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Werner syndrome ATP-dependent helicase acc. no. Q14191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUT4"/>
    <dbReference type="STRING" id="1076935.U4LUT4"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="429"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="843" mass="94391" checksum="AB8D2F8DE7A2822F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUW4</accession>
    <name>U4LUW4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX32001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUW4"/>
    <dbReference type="OMA" id="WCTCISE"/>
    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="6945" checksum="8604E76C29FD9F41" modified="2013-12-11" version="1">MCRRSQCANCSGVTWFGRCGLHIAQVLDPVPKEEWCTCPKPEGSSYPPIGPPPETLAMPAPTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV03</accession>
    <name>U4LV03_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV03"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7101" checksum="163853375F5C2018" modified="2013-12-11" version="1">MRRLTVGQKYASYRQVLGGFLVFDEAELLGEKRTADYCRPAGPSTPVTFSAAGLIFSDQPGMGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV34</accession>
    <name>U4LV34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Serine/threonine-protein kinase CLA4 acc. no. O14427</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV34"/>
    <dbReference type="STRING" id="1076935.U4LV34"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="120" mass="13770" checksum="475DE0B4C1D992EC" modified="2013-12-11" version="1">MTEAQVMEKIRSFVSSGNPNKSYTKIKNPASQMAAQNENGRVAIDIKQMDLAHQPRKELIVNEMLVMKESQLTCKGLEHLHDQNIIHRDIKSDNAPHLKITDFGIRAKLTEQKYKRARMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVY0</accession>
    <name>U4LVY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Actin-related protein 2 acc. no. P32381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVY0"/>
    <dbReference type="STRING" id="1076935.U4LVY0"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GDYRGWI"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="544" mass="59785" checksum="33CF99E3AF1AB49A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVZ7</accession>
    <name>U4LVZ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX33006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVZ7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="211" mass="23442" checksum="CB20541B9615663B" modified="2013-12-11" version="1">MQQGGLAQQPLTTAAPIQEQEIAANPLTQTIPEAAKVEQTLATATPIHGRVTFSQPLIPPIHQGEAAQQALLTAIPEAEPVQRTLRIIFVINDGEFNLKACTKPILRYVNALYLHGGENAPEPTFSFITITDDRAIESCVHDPDPDSRAVDIDFLVGKMHYNFHKMESDINLIKIQIPENYRSLKNIFEIKILLESPASEVFTSFRGNQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW10</accession>
    <name>U4LW10_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_14075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW10"/>
    <dbReference type="eggNOG" id="ENOG502QTNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTMWWLA"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="513" mass="55684" checksum="8DA3B3F19765E56F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LY00</accession>
    <name>U4LY00_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LY00"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7152" checksum="5FFBEEA6A934BC95" modified="2013-12-11" version="1">MYALSSPRSGGSVWRPAMGWKSLVVGHEVVLWEPEYPRPGGRRRSLLSRRGTPVADQGLGCDASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU03</accession>
    <name>U4KU03_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935198">
        <property type="protein sequence ID" value="CCX04327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU03"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6241" checksum="D51E3C03443D687F" modified="2013-12-11" version="1">MEEAASLYARICGSDYLYMKDAERVVKEWKNEIKEDDGGADSTYVEGAEDSNEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU26</accession>
    <name>U4KU26_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_03291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="HF935214">
        <property type="protein sequence ID" value="CCX04688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU26"/>
    <dbReference type="STRING" id="1076935.U4KU26"/>
    <dbReference type="eggNOG" id="KOG0415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX04688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="491" mass="55110" checksum="DBA8F98695EB248D" modified="2013-12-11" version="1">MSVLLELGEAGDIVIDLLTDYAPRTCENFLKLCGMKYYNFSPIYGIQKSFSFQTGDPIGPDSPASDGGSSIWGLIKGPSHRFFPSEFHPSLKHAEMGTVSMATAPSSLNPDERVSGSQFIITLGQNLDYLDGKASIFGKVVEGFDVLEKINNAFCDEKGRPLKDIRIRHTIVLEDPFPNPEGMVPPPESPVPSAAQLATVRIEEGEELGEEDPEVAEKRRRDREAKAQALTLEMVGDLPFADVKPPENVLFVCKLNPVTQDEDLNLIFSRFGKILSCEVIRDKRTGDSLQYAFIEFDEQKACEQAYFKMQGVLIDDHRIHVDFSQSVSKLSDTWRTSTNAKRQTAHSGGGRGFGGSSNLEKRGQYREDTRPARAGSQGGDYVFDPNEIKPAAGRDTKARQQDDRYRSSHDRDRYSGGRHDRDRGDRRDGRGSHGDRGGGNDRRRSRSRDGNGRRHRSGSHSRDRNRRSGRDDRGDRPRHRSRSPGRRRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV56</accession>
    <name>U4KV56_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV56"/>
    <dbReference type="OrthoDB" id="5401882at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="282" mass="32031" checksum="72BFA06446CA723C" modified="2013-12-11" version="1">MKQLCCIACNIWTWVAQKCSKCDLILCSQCVNVITRSDVRGNLKFVISVQARWKFGYSQEFMDREKSEAIRDYRNGLGHLKPIPPPERKSFMRHDFDNGGIDIVENDYVDCSSILNVPLWGDSESNFSVLLDEYVESDSDSEWEELVDCESVTTLGDSEYCSDTEDSFDKVPSTDKRNADTATLRALNLISKTKGYIRSRYNKGRGSLAKISRSMKYRKRTREGAREGAQNPIFKLEDLNPDGKLSNHGEKELLDDEANDEKVGGSGLQKRIVHEWEGCTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVK8</accession>
    <name>U4KVK8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein P8A3.13c acc. no. Q9UT04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935247">
        <property type="protein sequence ID" value="CCX05342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVK8"/>
    <dbReference type="STRING" id="1076935.U4KVK8"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSKSERY"/>
    <dbReference type="OrthoDB" id="5416588at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="489" mass="56285" checksum="039FE5F02C223842" modified="2013-12-11" version="1">MPPINETYSPRAHLHSSHRLTNRYNISSSPLSSLFPRNRFSSSTTSTSRTSYTPPQSYPTTMPSIRTRHRRRSISRRSFAPTPPRPSNENVKHSMSYLAALTRYRNTYYVQEIKDKIRDPPDDMVVDTEPLQVYKTSWLRKGAEFVGRQVAPGVDPLYVASQRNYSDSETSGSDTEGEHLDDAIVATVVQDLDRELEERDRNDPDFAETGQQNRDRNDPDYTVTGVDEGYRNDPDSAETEQQNRDRDDTDSAFNERLRALLGDFEVSTENQAGFIRLGYSRNIAESLEREAAEPLRPVVRRVNSMMDRNLRQNAQDAPKQCWEVKVKIFDIDWESLRITGSMTAFTGEEKSPLGAHSVETYLEGELLDFNTHSFETWNYKSNLDDDADNWRNLEPFKNMYDEELARNLLSKKFLKNLTENWVFMRWKEKCFISPQPDGNSGLTIGGFYYLCLARQSGEIKGFYYDPQSQPYQELILKPKPSAFTPQGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVT7</accession>
    <name>U4KVT7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Heat shock protein 78, mitochondrial acc. no. O74402</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_05004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVT7"/>
    <dbReference type="STRING" id="1076935.U4KVT7"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
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        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="122"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="519"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="10">
        <location>
            <begin position="689"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="335"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX05417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="796" mass="88129" checksum="24934CB8525F9B97" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVV1</accession>
    <name>U4KVV1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVV1"/>
    <dbReference type="OrthoDB" id="5430154at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="703" mass="76198" checksum="C517051570954303" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVX9</accession>
    <name>U4KVX9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Heat shock protein Hsp88 acc. no. O74225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVX9"/>
    <dbReference type="STRING" id="1076935.U4KVX9"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="677" mass="75806" checksum="12174A10CBC673F2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXE9</accession>
    <name>U4KXE9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Kelch repeat and BTB domain-containing protein 2 acc. no. Q5RDY3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXE9"/>
    <dbReference type="STRING" id="1076935.U4KXE9"/>
    <dbReference type="eggNOG" id="ENOG502SAH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRSELWQ"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="230" mass="26146" checksum="F59995F427B9C00A" modified="2013-12-11" version="1">MEALKFLSQFKTLMNSDLHSDLTIKVENSTFKAHKAILAIRTKFFTMATKEHGFAESKDNIVTIEDHSAHAVWRFLTYCYTGNYEESQNKDIDGEDDGVFLKHTRVYALADMLDVPQLKLLAAGKLKVRLALWRPKDFIKCVQETYATTYKNDLEIRNILVDAAYDNRAGLVKLEIFRQELEKMGEFSAALVFKITNEESKVQDPKASKAVAPLPQCWSGASISLELGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY35</accession>
    <name>U4KY35_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY35"/>
    <dbReference type="STRING" id="1076935.U4KY35"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NWEVRYS"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX04484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="334" mass="36910" checksum="454730534DFFD2C0" modified="2013-12-11" version="1">MHRNSPQIHHPVPQRPVQVPVMQSPPPPSHSSDPYDNPYGAPSYANMGGHQQQHHPQPGQNAGGGYPQQFTTFGQGANFFSDPMAAQMGFNVARAAMSGGTDFAEKNMNRYLSSLKPFFAVTNTYVLRKLSILLNPWRHAPWSRQSTSRSSSSRPGESETIYLPPREDLNAPDMYIPLMSFVTYILLSSLLYGLSGTFHPELLGYTASSAMGSVVFELVVLKLGCYLLSIGNSQLLDCMAYSGYKFVGVIVTILAKACLGAGWLSRGIFVYAYAANAFFLLRSLKYVLLPEENDAGYAGQRQMRKRRTWFLFGYAYVVQLVFMVTLTSGVGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY41</accession>
    <name>U4KY41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized RING finger protein P8B7.23 acc. no. O94271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY41"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRWKKCP"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="642" mass="71328" checksum="1537BDA4E38CF876" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYD9</accession>
    <name>U4KYD9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYD9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651510" evidence="1">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="195" mass="21958" checksum="A5680AD8406D0554" modified="2013-12-11" version="1">MGAGFTTILFFLRTTILCILKATKITPLIISPYYFTTSCFTTASASFVDCFNIPLAMAHMRDNRLICCRFSSSYSAPVLLGTIVLHRPQLLQHICSIIAFTSLRRICTVLWYHRLICGVFECFSNRLSCFWHHHPQQVALILLPHLFTLKKHVPLRAALPAMLLASLIHGKHSEWYQCSKPSVHDGSPDGTGPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYE6</accession>
    <name>U4KYE6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CCR4-NOT transcriptional complex subunit CAF120 acc. no. A6ZRG7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KYE6"/>
    <dbReference type="eggNOG" id="ENOG502QPV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MARTRCK"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="137"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1455" mass="159352" checksum="49AA01C3DE6491C3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYF6</accession>
    <name>U4KYF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Latex clearing protein acc. no. Q3L8N0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYF6"/>
    <dbReference type="STRING" id="1076935.U4KYF6"/>
    <dbReference type="eggNOG" id="ENOG502QTDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEFQYLP"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="106"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="52106" checksum="64966BF1ABB0DAAF" modified="2013-12-11" version="1">MILSLIDHLRGPRGPDVRNVWGYEFAWTDLHKTPEELLPLRESYDKLADETMRRLSILRGKRDLYTALEEEHVNDEVLGEFWRQAQTVPDWVDWEQIERGQKVFYRYGAAMLTGLAYNSLLGGMGANRIVEVLSRTGGFSKQVARRRMFETTQHILQCTKSLDSIKPGGAGHRSSVKVRLLHSAVRQRILKLHSENPDYYNLERDGIPINNLDSIVTISSFSASLIWMSLPRQGIFLRRSETVDYIALWRLIAHYFGCPTDPLATPELSRAYMESFLVTEINPTETSQVLSQNIIYSLANQPPIHTSADYLIAITRWLNGDKMADALALPKASIRAKIMVGTQFTLVAVFYYVYRSVAYLDERKIENSRRMLYRLLVEGKHGLGGETAFEFKWVPQMDTVTEAGRVDVTKGYQGHGGTLDEAIEGRSLKVLVVLVAVLWLLLAVMVRGLVWGVQRMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYI8</accession>
    <name>U4KYI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYI8"/>
    <dbReference type="STRING" id="1076935.U4KYI8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="371" mass="40762" checksum="2F3B25398A1D5A1F" modified="2013-12-11" version="1">MMEFALAPSRFIFTICLALLIVFCIQTARRLFDALIHDLHWRIFGNNESPIEPKNSQNDENCQDTSSCQRTYDLTHRASKKGRLLPSNTQSPSYLFGMVAFAARIPSVLADAGDDFSNNLLSDLAPILALFGENVANQYMSHSTSWIEDLIFAIGPLGIITATSGAIRVGGPSYLQAIIGRAREGNGIVELEFMSSTSTDVCELWNGKGISRVQGSAQPAPIIELYHLKYDESSNSIPGEDQSDDEGRGLLESWTSHISGKLPRFRPGRNHHRESYDDIRDEVQSLSGDWDSDPSMIYDFKSGREAEILTQINQNSTDPTNTDSSAPAPPNLGFNISYQRVSVLELRILAAIGILLQTAVLVFAGMTISPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ84</accession>
    <name>U4KZ84_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ84"/>
    <dbReference type="eggNOG" id="ENOG502T2KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10652557at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651179" evidence="1">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="196" mass="19156" checksum="3B1A4243368C5A05" modified="2013-12-11" version="1">MQFPVTFTSLLALQLTIISSALSAAVPDPSPVNAAPAIPAPPVARPLPAAPPSAEFPNGVPLVDLLPRAPVPEPAATCDNSGSGNSGCGNSGIGNTGTSNSGINNCGTNLSGIGEGCGDSSSSSGQGTTTVATDAAYTTTLIGPTSTVTVVADRNNRRTDCAYWRAQGYVCSGAGAVKAALGVVGAAAMGAVWVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZD7</accession>
    <name>U4KZD7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZD7"/>
    <dbReference type="STRING" id="1076935.U4KZD7"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="16573" checksum="9D3C87E2360BEF90" modified="2013-12-11" version="1">MSATGWDDKTVIGRNVRPGGAARPTVARTQAEINAARRSGAIVATDKKYATGNQVQSTDGQRLTKIDRENEVAPPKTIDKEVGKAMSKARGEKTPPMTQKDLATKVNEKPSVINDYESGRAVPNQQVLAKLERALGVKLRGKDIGSPLGPKGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZZ8</accession>
    <name>U4KZZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZZ8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8765" checksum="37417C052E2521F8" modified="2013-12-11" version="1">MWQHQPCRYCSAILSLFGSAFYSSPSNIIRLGVLSTPGLLIPYGNQQLLSGRRVEKSTLVFSSDSSPRHRGLILACMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0G8</accession>
    <name>U4L0G8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Synaptobrevin homolog 1 acc. no. Q92356</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07822</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935400">
        <property type="protein sequence ID" value="CCX08233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0G8"/>
    <dbReference type="STRING" id="1076935.U4L0G8"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX08233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12820" checksum="116F34B2B34318EE" modified="2013-12-11" version="1">MAETPYDPYIPANQAGGQGQQGSGNPRTAAIQQQIDDTVGIMRENINKVADRGARLDSLQDKTDNLAVSAQGFRRGANRVRKEMWWKDMKMRIWIVVGIIILLAIIIVPVVMTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0R3</accession>
    <name>U4L0R3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Transcriptional regulator prz1 acc. no. Q09838</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0R3"/>
    <dbReference type="STRING" id="1076935.U4L0R3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMHHIPR"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="391" mass="42594" checksum="0589EFCCC79FDD28" modified="2013-12-11" version="1">MIKNEFSGNSHADAAQSASIAERRQRESLPRFDLTNARANFGGISSFPTPPPLGQHEMANSLTGSNVAGVSSYGGYQPSNASPFGYLPGMGSVHAARSSFNSPGTYGQRNVNRPHSPSIGEMVPSSPYENAVSTMSLPGRSPSGSIGQQDSSYASSYNQHNHLNSQPQQPTTHNLYSPHSGSAPPPPPPPPSSGSYYTSSYPPLPQMSPNSPSSTRPMSAGTSSYQTSLVPLQPQPHPQYRPPYSLPVPMGSTVMGAGHLGNSMMHHIPRAHHPVQDRPFKCDVCPQSFSRNHDLKRHKRIHLAVKPFPCDNCDKSFSRKDALKRHRLVKGCGKASELRLQAAAQQQITEQQDQDRNKMQSPNHHSSHHDRNVRQRLSPHHSSHSPVDHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0T7</accession>
    <name>U4L0T7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0T7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4932" checksum="FFE5A9EF223D9914" modified="2013-12-11" version="1">MHRSEVGKLERIHEHTGTYTTKPAPGSGYRSCTPKFLTGSGRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L182</accession>
    <name>U4L182_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935394">
        <property type="protein sequence ID" value="CCX08174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L182"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8207" checksum="D08E75511286538A" modified="2013-12-11" version="1">MRDGLQDVYFFSCRRKFFCRAVGARWINSICMYMVSCDSETSTGLITAELQSFDPLTLDTPNSGAEMKQLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1D1</accession>
    <name>U4L1D1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Transcription-associated protein 1 acc. no. Q9HFE8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935444">
        <property type="protein sequence ID" value="CCX09211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L1D1"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLDLYGQ"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2608"/>
            <end position="3164"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3430"/>
            <end position="3755"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3752"/>
            <end position="3784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2006"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3187"/>
            <end position="3256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2008"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3213"/>
            <end position="3237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="3241"/>
            <end position="3253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX09211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="3784" mass="430316" checksum="DE79DAE24E85CC32" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L209</accession>
    <name>U4L209_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Centromere protein X acc. no. Q2NKU0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935434">
        <property type="protein sequence ID" value="CCX08886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L209"/>
    <dbReference type="STRING" id="1076935.U4L209"/>
    <dbReference type="eggNOG" id="ENOG502SH0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQSDVGW"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX08886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9643" checksum="690A8D43416B75F0" modified="2013-12-11" version="1">MSEAEIPPELLTRMLQEFSDDKRTRISSAALSALTEYFSTFIREAIWRSAEMRKNEAKKGGMEGGTVFLEVEDLEKAAPQLLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L244</accession>
    <name>U4L244_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_08798</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF935444">
        <property type="protein sequence ID" value="CCX09205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L244"/>
    <dbReference type="STRING" id="1076935.U4L244"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX09205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="399" mass="45469" checksum="7865C9F80C3E88B0" modified="2013-12-11" version="1">MAEGIDRREDQRLEFSTSKEVTVAPTFEAMQLKENLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISILQVIDTAVRETQALVLSPTRELATQIQSVVMALGDYMNVQCHACIGGTNIGEDIRKLDYGQHVVSGTPGRVADMIRRRNLRTRNIKMLVLDEADELLNRGFREQIYDVYRYLPPSTQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGDMPQKERDAIMQEFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTTEDVRILRDIELFYSTQIEEMPMNVSDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2E2</accession>
    <name>U4L2E2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Phosducin-like protein 2 acc. no. Q12017</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX10009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2E2"/>
    <dbReference type="STRING" id="1076935.U4L2E2"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="76"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="274" mass="31521" checksum="C5C0394976F63CC3" modified="2013-12-11" version="1">MNAGMPNMGDMPIQVPIDDPNADTEWNDILRAKGIIPERPPSPTKAFEEAVQEAVQEAFKERFDYVPTDRLAELQEEFDDLDDDGEDAELIARILAQRKAEMIAQQSAPHGMVYGITKADYASDVTEASKKYPVLLHLKSNNDANVESRLLTQLFREAAPTFRDIKFCEIIGNKCIENYPESNCPTILVYKDGEVLKNLIKLGEMRGTDTRIRDFQQWMVRLGLIGKKDQRLIGRDDDEDSDEDWEDKPRRGFTKQVRKQNRYDDDDDDDDDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L301</accession>
    <name>U4L301_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935202">
        <property type="protein sequence ID" value="CCX04415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L301"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="220" mass="24527" checksum="1E4ECA412333A3EC" modified="2013-12-11" version="1">MDGHQGECRESRKRKPEDQNTPIPAAGMPPSKKTVITTLQVGKAPPWVPKTRSATVRELGLDAYNENMDPGDLSNTEGEGPSFSQVEGKLDVYDTHPAGQAYSAMKADPKHYKAVRLVLYCIRTFFDEQRNPSYPRPGFFAMPGETFEGALMRQKAHQEAANEGLKVLASTLGIEWKTDKINFYNDEFLAYLSNTPRDEDNQNLKANDFIIALGTIAPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3J2</accession>
    <name>U4L3J2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Translocation protein sec66 acc. no. Q9UUA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3J2"/>
    <dbReference type="STRING" id="1076935.U4L3J2"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYWQRYQ"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="22930" checksum="D4653272A1B81294" modified="2013-12-11" version="1">MQLPTLDFFYSLIAPLSYIVVLVGSLGTFSSLYRKRKAAKAAALEPWFPAHTTRDIYLSLLHLEGENEAPDSQLKAALMLRAKEDIKRLMALRQSKQPLQMLLQKGCVGDDVWTRFSQAEAEMEEELRDVVMDANAYKEGWGQVIFQTANEMVNHDRLRERTEQVEIEAAEERKWWDEKRARSQRELLAEEAATKKADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4F6</accession>
    <name>U4L4F6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935654">
        <property type="protein sequence ID" value="CCX11902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4F6"/>
    <dbReference type="STRING" id="1076935.U4L4F6"/>
    <dbReference type="eggNOG" id="ENOG502QWTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX11902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="491" mass="53980" checksum="2EE7DB436BA857C4" modified="2013-12-11" version="1">MSSSRGRERTETRQLHNYFGKRVFITIIGEYLNTSILDNIFTMPYPFTLPTTSAISFITNFNSPVFPSLPLVASEHRGTVRNLLKSYKRLSPSQQATQLPQLLTALTTYLPNLLFLQSSLHSGDVLPSDSPKPFTPSWRTNLSNTTFPSAAKRISHPGLDYELAFTLSTLAYIHTLLARSQFHEALSNIFPEKKQTLLNNAIQNLLTASGIFTYTLTLPQVPGSAFPVDLCPATISALASLSLADATLLAVVKQDPYPNYLALSSGKKEGSGYLYAPPTAPTGVKALLLSRICIAASVHAEKALGSLVTADVVPELRKYLESLQKVARAKACRFLAIDAEASGRVGEGIGWIILARNILGEKGKMKREFLERREARGIEKADSTWGLDAGRLEEVRVLEGLEEKWRRSNDAVFFQAIEAEVGLAARIPSGREVHSVKSWEPPTLDAGQKKGLRREDGLAERMEALGWGSGSEEEEERPAPSRRANTEGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4L3</accession>
    <name>U4L4L3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4L3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9717" checksum="12E5F56B9E51FBF8" modified="2013-12-11" version="1">MHGATTDRYMEKEAWEQIIQFIYISHHFLPGGTYPLTYYGQDIWSMRPEQKVYLKYRETNEFLKALGTLHDELWDTLLDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L508</accession>
    <name>U4L508_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L508"/>
    <dbReference type="eggNOG" id="ENOG502QPYF">
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    </dbReference>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="571" mass="62816" checksum="51D1CD537238EC2F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L550</accession>
    <name>U4L550_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935586">
        <property type="protein sequence ID" value="CCX11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L550"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="6356" checksum="3EC27FF0B3A661E0" modified="2013-12-11" version="1">MPPVNAYASMIGQRRQYEPLTTIQSRRMIFTPRKQPQYQCLEDPMLSDKKGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L622</accession>
    <name>U4L622_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L622"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="233" mass="26231" checksum="EE158C93BE75B150" modified="2013-12-11" version="1">MSFISFSRLRNPFSSRPPVENYQLLFSTPPNVHIVAGSLGSFSTISAANRAAALAASKSADELCKAVHAAHKGNPSSSGVAIFRELPGVEIGYKIWYDIGGMAHFESTLPWSDPRYQMIWVGHKDDHEKRNQNIEQWHWDNCDEDDYLDLDAEHDKVSVDPLDTSQLTPGELEITRDISIQDAQTSWKGEEGRERVKNRIELLQAMTERNGDPEWQPISIRSSDASWVMFDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6B2</accession>
    <name>U4L6B2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_07560</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="HF935384">
        <property type="protein sequence ID" value="CCX07971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6B2"/>
    <dbReference type="STRING" id="1076935.U4L6B2"/>
    <dbReference type="eggNOG" id="ENOG502QRG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
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        <source>
            <dbReference type="EMBL" id="CCX12240.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    <sequence length="525" mass="56612" checksum="440F48084954D898" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4L6Z8</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <location>
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            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12889.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="250" mass="27286" checksum="E21AE9E8CBAC49C5" modified="2013-12-11" version="1">MGIPLWRDPTAPGYVPDPPAATAAATTTSSCPYTVPSNPTSRPALTTAAETLASLTEILRASGRAQNDVVFMLSRQRRQRVLDAETRLMNAEREARNAENDAASNAATFGGGENDVATNADTSDTASNAATVGQPRDDLTAATARHAAFQVAHPLPSDAIDSFQHLVNQIRHIGNLQDAFLNRDWNTPEPESREPEEPGPERIVVGTAEVGQRNPVEELARLREREARLRGMQYPPKTPKNRMREAWNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7R5</accession>
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        <submittedName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7R5"/>
    <dbReference type="STRING" id="1076935.U4L7R5"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KQPPEQD"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="783"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX13713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1167" mass="127817" checksum="5E12B1BC51DBACA6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8M5</accession>
    <name>U4L8M5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Galectin-3 acc. no. P38486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8M5"/>
    <dbReference type="STRING" id="1076935.U4L8M5"/>
    <dbReference type="OrthoDB" id="10452751at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="477" mass="51290" checksum="75421E8C65F67BFA" modified="2013-12-11" version="1">MPVFPEIAAPGATPGLKNNATSSSMENDNMVATDINPETAAAAFIPAVSTAPSNTEKEKSAIYPALLPPARYPALEDPGRYPALEAPGRYPALEDPGRYPALEAPGRYPALKAPGRYPALEDPGRYPTLEAPGRYPSLEDSGRYPDLELPGTLHRRSWDSWKDSASRFWNDVTSYNVFGTESTPDPIPASVYDTTLIPLSSPPKELYTPASAEDYSFPATINVNQRNDDLGLTANLWNDHLSRPLPAVDASISSMPDADSPWSVRQSITPGNLVIHDLPIEDRYFVEENAWVNTKSHGWEQKPKVVAPFAPSYAPTPEMVDLHSFDLPGLSSGSSASSSGSFSPWSIDSTASSSTDSINALGRDIVAAEGTGRNAAQQQSFQDRLDKLMTTPPGVGIGGLDRAGHRGYPVVAQRDVALGMPPVRSLDWAAPSAAPSAAPNFAPAIMSSGAMVQEPEKTIMFLMVLFCLLFGKFFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L966</accession>
    <name>U4L966_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935304">
        <property type="protein sequence ID" value="CCX06669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L966"/>
    <dbReference type="STRING" id="1076935.U4L966"/>
    <dbReference type="eggNOG" id="ENOG502QSJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GYAVMMQ"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40887" checksum="ACF792667BB1259E" modified="2013-12-11" version="1">MAAAAVQTALHTPVPAIRGVKTTPMGKPKFQLPLQRPLPPAAYFKSPFDPFKHLAYHTMPARHTMADIGLENQGISTIGVSEPFELFTPEAVCTMRNEVLSDEVWDNCRFSSSIAACQLRGMAPQYAKFVYDAWSNPETLRIVSEIAGVDLVPVMDYEIAHINVSVNDNPDGENQAAPVVNWHRDSYPFVCVLMLSDASEMKGGETALKTGSGEIMKVRGPQMGSAVVLQGRYIEHIALPSTNCRERITMVTSFRPKNPIIADDSQLLTVRPVSDLSEIYNQWTDYRVEIAEERCKSLIKGIREKKRVGRDFDVDGVKGQLSDLIKFLQKTHDEIVDPAQYQINDSEEEREEQASTRMKKRARMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9N0</accession>
    <name>U4L9N0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Mitochondrial aspartate-glutamate transporter AGC1 acc. no. Q75AH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9N0"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="25192" checksum="FD426DCB1CF26476" modified="2013-12-11" version="1">MRLSLRIIIRSPESSSGSCAGYLTLEEWDTFESLLSKPDADYQIAFRRLDVEGKGEFSQLLRVIQGEKVRLAFDTKATGFIEVANFMRIVQKTDILDNLNTFISVGTASKIPYANVRAFQNVVREMDTIDTVVRSATAKSKDGKITLPLEMLPGGTAGACQVVFTNPLKIVKTSLRVQRELTRNVVDTPRRSSLWIVKNLGVVGLDKGLPSILAQQRSLPAYDEDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9X2</accession>
    <name>U4L9X2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9X2"/>
    <dbReference type="STRING" id="1076935.U4L9X2"/>
    <dbReference type="OrthoDB" id="5387662at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="559" mass="61336" checksum="80EEBA1EC91FB3BD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA53</accession>
    <name>U4LA53_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA53"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8404" checksum="A576E47F85387E33" modified="2013-12-11" version="1">MYYDVGFTGCAYTTPTKTNYLGRAGECHILSKKIAHGCRETNRAQMSSATKGKQNEQESVRIINRGVAGEYVSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA68</accession>
    <name>U4LA68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Probable 37S ribosomal protein S12, mitochondrial acc. no. O14182</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA68"/>
    <dbReference type="STRING" id="1076935.U4LA68"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCIRVYT"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX15857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="172" mass="18897" checksum="6A67E5B75E5BE6BD" modified="2013-12-11" version="1">MFALRSVFSALPRVASTVAAVPRICAPRIPTSIAPILPTNPLGRRWATFNQVLRGCRKKQRARKPVSPALSEGKRPCMKGVCLRVTIMKPKKPNSAERKIARVKLSSDRLITAYIPGEGHNVQQHSVVLVRGGRAQDCPGVRYHLIRGALDLGGVPNRITSRSKYGTKKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA79</accession>
    <name>U4LA79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA79"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15263" checksum="26696292883AD88A" modified="2013-12-11" version="1">MSLGNAGHLHDYYQQVSGGVIQHLHLHHGQIENYSSPIQLDSHEPLLPWEAWLTPNPSRRGSLEISAPSQASVQLLQQAVSSTLLGFNDDILDIDDFDTDWRSKGMNFPHTEPSIILDTVDPQMTLFGNTNSYTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAF0</accession>
    <name>U4LAF0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936136">
        <property type="protein sequence ID" value="CCX15147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAF0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="772"/>
        </location>
    </feature>
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</entry>
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                <person name="Kumar A."/>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF11970"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CCX29733.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
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                <person name="Marcet-Houben M."/>
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                <person name="Gabaldon T."/>
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                <person name="Marcet-Houben M."/>
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    </evidence>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5763" checksum="3BFC6E9F7DB5AA44" modified="2013-12-11" version="1">MGFKTRLSRASYILGISVSIFLLDLYFIEGCFQQSIAITPRSTGFDRVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEV2</accession>
    <name>U4LEV2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEV2"/>
    <dbReference type="STRING" id="1076935.U4LEV2"/>
    <dbReference type="eggNOG" id="ENOG502SPX8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVANELE"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651937" description="Wax synthase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52539" checksum="36644A337319B388" modified="2013-12-11" version="1">MFLHLLLIILLGLLSSTNASPLPPVWTPPIDDPEALYNVLAPSWVKEPLTRGTFSIIFPCLATLGLCVYTGIHLNIPAHHDSQVKVAFRKLKWSIIALFAPEMVLYCAWQQWFQAKALRDRMNAALDAKAEVERRPVDEKYSYDISTAFWVVMGGFVVRCSEEVGLGPGTKGVRVGEGGESTRVLTPAMVVALAEDPLAVGMTSFLKIEPLQREDKNKADALAKLLVVGQVLARVIANYPVSLLEIHTFVHVICGLIMYYLWFNKLQGVGLAVSVELNPRQISILTSLPYWNRSSHLTRIPNIQNRIDSGNGLIRLSRKPVDDRLYLALVCAMYGGVHLTAWYSYFPTLLEEWLWRASCFTMLIGALSAPSLVLMCEFMADWKQAFPQNWFWTGITKFCFTIPWKGRNDEVSLAGTALCVYRVLALVWFLPYLVARMYLVAEPFASLREMPAGVYAVVSWSLNVPHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF59</accession>
    <name>U4LF59_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF59"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="13309" checksum="D5556C537DF17A4B" modified="2013-12-11" version="1">MRTGPDPQSSTSLNIWTSCLICRVNLHIGFFEHAFCKPLLQQSLFFVVSNVKDTYSFCRIFFFFRSRKCKSRDAKLINGQATNRRLMPGWKPSGTFKTHEHTSLDAALLCFPTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFF5</accession>
    <name>U4LFF5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_08955</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFF5"/>
    <dbReference type="STRING" id="1076935.U4LFF5"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RPWWICQ"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="98"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX30618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="539" mass="61322" checksum="32383F4E43F7A0B1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGB2</accession>
    <name>U4LGB2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGB2"/>
    <dbReference type="STRING" id="1076935.U4LGB2"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANDACEV"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="42338" checksum="48358B5D2DBE6B86" modified="2013-12-11" version="1">MAHDLSIDTETDSISNFSIESMASIEADSDLDEVSSQYDSCYSSIGENTCTLYSEITNYKWENGRRYHAYAEGSYWAPNDEKQNTQLDIFHHVFSLMLDGKLFLAPIEQPTNVLDLGTGNPGIWAIELADAFPNATVLGNDLSPVQPTWIPSNCSFEVDDYLRPWLYPPGSFDLIHARGCYGSVSDWSLFSTEAYNALQPGGWFESVEISSIFRSDFYPGNALPDTSLVKQWGQFANDACEVTGRPMDIAGHVGGFMKKAGFINVVQKSFKIPHGPWPKDEKLKTIGKVNLVNVLEGAEGFTLALFTRQLGWSVEKTMEFLEKTREELMDHKKMLWMHMVVAYGQKPENAELPSETESAYDSAYASSSRRGDVMSMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGG5</accession>
    <name>U4LGG5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGG5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="13133" checksum="6A40A93B19EAAA79" modified="2013-12-11" version="1">MSTASSPIILIPPNLECGDSLPDFETAYEFHRYILKHRSLVAVRIGPTKWQATEQHTQWMVKGNWNVFAAGFRTVEAISCAARMAHHMDGTCCGMHKELLECEVVGNDTPERQTSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGQ3</accession>
    <name>U4LGQ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Retrovirus-related Pol polyprotein from transposon TNT 1-94 [Camponotus floridanus] acc. no. EFN68697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGQ3"/>
    <dbReference type="STRING" id="1076935.U4LGQ3"/>
    <dbReference type="OMA" id="WIMWANI"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="470" mass="50848" checksum="C70E5D18F4DE02D7" modified="2013-12-11" version="1">MAASAANDPMVPALTGPQNYPIWRQSLKSLLNSKGLWKLVDGKEPLNTSKPIALGASAWDTDFSASTDLAYAERNELAYDLLIINIDPSLQAHVAHCKDDGKAAWETFKRLFDPSNITPSRLQLRRDLYLPQKLGESIRAYLDRKEAVAKQLQESNTGIDDNEVCDAILIGVEERYKELVDMLSKRGGYALKEVKDSLLKAEKELPAVPTPAQSMEGNRKPLLGAGADINVSPSTPLRPAPSKRPHSPGPAGQNDVDKKRSRSSRKPRFVPVLPADAGNSTPVANNAADGAVVPAAGAANATPVVAGTSTSLVPTSSTATPSPPLPYQLPIVVPSPVFSVSHPVVKHSVLRTNGSVISTIFTCNFTTGAATSLVARTARLTLTERICSDSTLSGCMRPQILERSRNGVKKNEENPRREVFVDSVQGCLKAREVGRLVWIMWANIIRMVLLEENGKLMMGLWIGLLGRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGZ3</accession>
    <name>U4LGZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGZ3"/>
    <dbReference type="STRING" id="1076935.U4LGZ3"/>
    <dbReference type="eggNOG" id="ENOG502S6E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVSEIRC"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="651" mass="74169" checksum="C80C4806186DDCE2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH22</accession>
    <name>U4LH22_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936243">
        <property type="protein sequence ID" value="CCX15613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH22"/>
    <dbReference type="STRING" id="1076935.U4LH22"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="10017" checksum="1BEEA6860A8DDF29" modified="2013-12-11" version="1">MYNSHTRVVQLTPHSIDLFQRHMKGIYAGFIMVEAKDCEADARQHQAVLETDTNIPTRNGEQWQALIAFHRYLLHEHHEFFLGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHU8</accession>
    <name>U4LHU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YOR389W acc. no. Q08912</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHU8"/>
    <dbReference type="STRING" id="1076935.U4LHU8"/>
    <dbReference type="eggNOG" id="ENOG502QRJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DEFCAIP"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651382" evidence="1">
        <location>
            <begin position="30"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="470" mass="53173" checksum="881456753AC5E292" modified="2013-12-11" version="1">MLPSNSGILATKAMFVSLLVFLLTTLVGSNQIPFVHAEPQTSARNAAYIFSSLRGLMRQNPNTHNPNGFSISAATIPAFTTLFHARKDSGAVPKVEWLAFDSEMSYAIMGGQKGPGTWMHTYTTTRRAKVLIFDGMSAVIRRDGSMDSQMVFIYGTVATGAPTLNSGDPVWSDGPEYERAEILCAWAKDAGVEGFIRMATGFEMLWCDFGSDALKELSHLEIPSKESVSITGVPWANAAGWEWIRSASWHFENPELRVMPDYCRFFTFYSPDYTSFPSNLTTDKKLHRLEGVKAEDTDKFKTMIKETMKNNKLPCSGLDWRRVSDDVVDRFSARLQELMKANTQERAKEIAYAVIVPFMGDANVMTRCAWVPKPDNMSPQEVLLRDSVQYVLQKICALFQKVLESERLKWKEEARDMIKWLDWSEWKTCGQCAEEELCVPGPMWPVLGLMDWQEWTGPRCIKRGLVERKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI67</accession>
    <name>U4LI67_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI67"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="26" mass="3128" checksum="5A5B8A8F2A5B56DB" modified="2013-12-11" version="1">MMSKRNGFSVVLWRVLPTMRQWGFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIL8</accession>
    <name>U4LIL8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_10668</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIL8"/>
    <dbReference type="STRING" id="1076935.U4LIL8"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SVFIGAW"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="856" mass="91056" checksum="1EE7F65C3AC81E6F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIN4</accession>
    <name>U4LIN4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIN4"/>
    <dbReference type="STRING" id="1076935.U4LIN4"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWMPILG"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="265" mass="29433" checksum="35ABC6A6204634F8" modified="2013-12-11" version="1">MVVEFTSKHRYGEQGEVYFNDGRELDLLKHIFGLPAEQLDRLRGNPTAVLEAIDKFAEEKYLMNIGELKGSHVTALITKHKPSLCLELGGYVGYSCILFASCARAANPSAKYYCLEYNPVFGAVIMALVHLAGLEDTVRVIIGSSTDTIKRCSKDGTWGKSGADFVFLDHLKPMYTPDLRLMESLGVVRMGTVVAADNMVKPGNPPYHEWVNADKSKKEEIVKSVKGEERGKTGIRYENTWIESWEPQAVPDAIEVSVVVECPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIZ5</accession>
    <name>U4LIZ5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="HF936505">
        <property type="protein sequence ID" value="CCX16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIZ5"/>
    <dbReference type="STRING" id="1076935.U4LIZ5"/>
    <dbReference type="eggNOG" id="KOG3101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSDCPWG"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32052" checksum="A6B47A813DB2E3DB" modified="2013-12-11" version="1">MTFETKATIANFGGKLLKLSHQSSETKTPMALNLYLPPNASASTKVPVLFYLSGLTCTGDNCSEKGFLQAHASQHGIAIVYPDTSPRGTETIKISDRDAWDFGTGAGFYIDATTEGFKENYRMYSYVTKELPEALWGAFPQLDSTRVSITGHSMGGHGALTLALKNPGMYKSCSAFAPISNPVNCPWGQNAFTGYFGEENKEKWAEHDATELVKKLKEGDKFAALIDVGTGDNFYKQGQLLPENLETAAKESKADVKVEVRYQPDYDHSYYFISSFGKDHIEYHAKFLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ12</accession>
    <name>U4LJ12_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to RING finger protein ETP1 homolog acc. no. O13747</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="BRAP2/ETP1_RRM"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
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        <location>
            <begin position="366"/>
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        </location>
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        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
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        <location>
            <begin position="553"/>
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        <location>
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        <location>
            <begin position="303"/>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCX31557.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="651" mass="72635" checksum="7BB599BB61A37F22" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <end position="425"/>
        </location>
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            <end position="375"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="425" mass="46933" checksum="B30A3C1F51374758" modified="2013-12-11" version="1">MPSKKNQPPKPTNLPPGNLDWSTAVPYFIPPQIQPITNNYTTNIHITNFNALGVLPSLPLPVPSIPPCDTDAIDSLFPLSPSTRHHHLLHRELINAFYISLGNPDGTTRHLVYRWLRTEAGIEILSKIFGLSGRVNAAGIKGGIETVLRVLDPRYREGLLRRGNVAAHVFSLEEAMGVVGVGGGKAGSSMGSSGPSVRPSAPLAGKDLVINDTDTEAQPVLKAILNLLRSKSQNPAMEDLKTAAYHLKLELLGLYPRLQEVVDIEKTAGRGNLVNDILYRMRGYGEEEKIGIVGEVRWRVEKDPTDTGRMDWWADEGEEGRGRYREREGLDLATASFPGIPQQRTPEKMERMGSPSKQNWDASSKNMGYQKQPGSNKLDMPWRSAKVDQNKNQQNHESQGNQGFRAPSGMRNHRRANTMSGIAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKB7</accession>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6153" checksum="40DC663476B13223" modified="2013-12-11" version="1">MYRYANDEPKQMETWSRQIILRCTSCVSANQLAIAAGPTLGLTSQPSRPASNLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKE1</accession>
    <name>U4LKE1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_12317</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
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        <property type="protein sequence ID" value="CCX32047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKE1"/>
    <dbReference type="STRING" id="1076935.U4LKE1"/>
    <dbReference type="eggNOG" id="KOG1395">
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="379"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX32047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="724" mass="77696" checksum="09C3AF28C01B23E4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLE9</accession>
    <name>U4LLE9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLE9"/>
    <dbReference type="STRING" id="1076935.U4LLE9"/>
    <dbReference type="eggNOG" id="KOG2143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECRVESM"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="639"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="773" mass="89143" checksum="441E7E867ED07DD2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLL4</accession>
    <name>U4LLL4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLL4"/>
    <dbReference type="STRING" id="1076935.U4LLL4"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KMEDQEY"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="16552" checksum="B8F25A0908C70876" modified="2013-12-11" version="1">MPKNKGKGGKNRRRGKNENDNEKRELTFKEDGQEYAQVVKMLGNGRLEAMCFDGEKRLAHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVILKYTADEARNLKAYGELPENAKINETDTYGHEGADECNFEFDVEAGEIDIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLS0</accession>
    <name>U4LLS0_PYROM</name>
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        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized WD repeat-containing protein C17D11.08 acc. no. O74763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08422</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="520"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="632"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
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        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX30280.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="731" mass="77789" checksum="61025420993B4AC1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMI3</accession>
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        <submittedName>
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    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="19" mass="2013" checksum="A918E777A7301CCE" modified="2013-12-11" version="1">MASHSVSPFCYDNATALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN06</accession>
    <name>U4LN06_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to mRNA 3&amp;apos acc. no. Q4IPA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936243">
        <property type="protein sequence ID" value="CCX15604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN06"/>
    <dbReference type="STRING" id="1076935.U4LN06"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
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    </dbReference>
    <dbReference type="OMA" id="WAPRNCE"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="333" mass="37729" checksum="E33D4025CDC3CB3F" modified="2013-12-11" version="1">MAETEDEGFADEKDQIEVDEAISLDSFDSTNSSTKSLSESVHEYIFENGRRYHAYYETDKNMMPTDEKEQDRLDMQHELMLALLDGKLHLSPLVEPQRILDIGCGTGIWAIDTADEYPAAEVIGTDLSPIQPKWVPPNCRFELDDAELPFTFKPNHFDFIHMRNVSQSISDWPNVLSEVYRCTAPGGYVELAESGSDIRCDDRTMAMDDSFKVNVDLVIKALDQIGRPPATDTILRERLEKAGFVDVTVVNTKQPLGPWPKNRRLKILGAMTLMGMEAAIEAHSLATLTRILHMDHEDVNEICRKSLEAARNRGIHMYSFHHVVYGRKPGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNA3</accession>
    <name>U4LNA3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936058">
        <property type="protein sequence ID" value="CCX33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNA3"/>
    <dbReference type="STRING" id="1076935.U4LNA3"/>
    <dbReference type="OrthoDB" id="5430673at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="460" mass="52036" checksum="55BB98D6E8BB49B3" modified="2013-12-11" version="1">MVNWSEDIDLTLISVLISEARAGKKTQNGFNSSTWEKAMSKIVSAHKVLYNVSQIESRYVYLEDEYAIFLKPKENWELLFDSNSENKIPSPTAPDDVWNTYIAKNQKKNAMKGHRFRILSTFKELDEACGGILATGEFARHPRSLVQTAQAAQVPNDSTDQPEAVDPPPPRVKRTDPKVTPNPKTQQTPPQSTKKKARSDDNDKSTGSGSRKRSARTPSPAELNSETSDGDGSDEGSRSSTQTKQGGRHKKRRKSYGRDIIENMEKATAAFITAVEQKTAAMEQETAAMKQKIAAMEQQTTSATSRIPTASKELIKEAIKKLQKEHNPESVDFEDVFKLFDLFVLNPLKASIFLVLKNGELQDLWLEHQVEDMRYIQVAAMEQQTTAAIGRNPRASEEAIEHIQEQYRDTDLRLEDGIRKYMFRAFEFFMLNPIKASVFLALDEGNLREAWLERYLEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNC6</accession>
    <name>U4LNC6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNC6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="234" mass="26673" checksum="2DEA72064049438A" modified="2013-12-11" version="1">MNPTTTTSRVDEGLQIPGAIVHDPFENYHWWNGDVTSPTDPNPPECCIACCSKPLCCRPRDKYEIAFMVLRMVEFAIGLFFTIPFFRMADIVYIIEFLELSPIFYMVLFPVVTGLLMTILGCVTHPSHKFPLWQMILEIVLQSTIECIAIVVLILMVLSGTDAWGMLLLLVPLMVICALLIALDSYCIAKRHTIRNEDMKVQKTSLSIEIPQVNHHETGQNNGHGFWHTIFPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNH3</accession>
    <name>U4LNH3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNH3"/>
    <dbReference type="OMA" id="RLEDHME"/>
    <dbReference type="OrthoDB" id="6357876at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="331" mass="39059" checksum="22802161AE91AB32" modified="2013-12-11" version="1">MRIAGRPDILHDDLEASVDKRNITGLMIDVQIPDDVIIDEDEEDILGGAMDTTMHREASFTKGDDKEKTRHREVAGIQEEDMVAEEMERRLRSLEEREKLLGERERLLEEKERLMTASFGEKKPETNPLGRMMDAFHDAFNKKDELKVDHRATLEEHRSIHRASEQQRMDHRSQEPKVDHQAQAQEEPRISHRSQEEHRIDHRSTSEQQTTNHRPQNEPRLEHRSTPEDHRTLHRAQEVHRVDHRAQEPMVDRRSQEQQLGHRSEDGPRMSHRSQEEHRMDHQTTSQQPSIDHRSQDGRMDHRATPKDTKLSHRAQQSRGDTQVQEEHRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNI3</accession>
    <name>U4LNI3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNI3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="15548" checksum="6DE91939D6461F88" modified="2013-12-11" version="1">MVVEDEEPEVKALLAALSTGNMSAFANPTTTPALTLEDAQPEDVGTGVQAALLDSYGMMAPHISTAVVPTLDLSRLRSLGPILAAQAKTAAAATVVRPAIAPNGTSSTVDSQAPIDESEPEAPPPDVIHPLGDAVSSATEDKAPALRTPREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPE6</accession>
    <name>U4LPE6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPE6"/>
    <dbReference type="STRING" id="1076935.U4LPE6"/>
    <dbReference type="eggNOG" id="ENOG502S6I6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RRWAWLE"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58993" checksum="F35CB243125DA8F9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPG5</accession>
    <name>U4LPG5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Lysine-specific histone demethylase 1 acc. no. Q9Y802</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPG5"/>
    <dbReference type="STRING" id="1076935.U4LPG5"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RAWASWN"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="507" mass="56237" checksum="5F493DE2DF08C651" modified="2013-12-11" version="1">MLQPTRHKIAIIGTGISGLSAAWALNKTKQYEVHLYEASDRLGGHTNTVAFPHKGREVMVDAGFAVLNDATYPNFLSLLDHLGIKTEPTEMSFSITSSIASCSSWSTVSLLSLFAHQQNLTSLSFWRMLFDILRFNLFSPDLLTVTDEDEQNITLGDYLDREGYSEKFRRDCILPIAIAWNGSPGVRSALRIPAVSLVRFMRNQNMLRGIWGEETTCLTLKGGAKSYIDVLIHGIPKWKIHLSTPVKEVGTREDGKPYLKIIEEEAGECEFQYVYDHIIIATPGDEALRLLGSGATVKEKEILSAFKTTKNKVVLHSDLDHMPALKSTWAAWNYLTTTSARTGGIDKVELTYNLNILHHLRRSAFGDVLATLNPITEPAKKSTQGVYQYHVLVNTQASLAARKRIEMEIQNKRGISFAGAWLGWGSHEDGCASGLKAAERLGVMMPWGDGKVIDSNTVGTPTHPQKMDWIMGLVRMVVWVLSVWVSVVEGLVEGIHDVRKQTGNGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPL3</accession>
    <name>U4LPL3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="7" type="ORF">PCON_02584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPL3"/>
    <dbReference type="STRING" id="1076935.U4LPL3"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PCTRCQM"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="611"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="787"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="844" mass="92385" checksum="4D7AF0558EF54AA9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ06</accession>
    <name>U4LQ06_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ06"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6374" checksum="253A53472199C167" modified="2013-12-11" version="1">MTSVTCASNRISPPPDACSTQNISRIETRLDPSGQVLDTYCLTSTITIPKQSNLCNGDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQP7</accession>
    <name>U4LQP7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQP7"/>
    <dbReference type="STRING" id="1076935.U4LQP7"/>
    <dbReference type="eggNOG" id="ENOG502QPYR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYRPRLN"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651821" description="Phytase-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="129"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="500" mass="53860" checksum="84A470791B2EBEE3" modified="2013-12-11" version="1">MKGIFSLVTAFLAAGAAAGPLRTKAAPVSQIECAGMSFTYESLAGYGRLAGNFVDKYGDTMSIGSGISITEWKPVEGGAFEATMFVLPDRGWNTEGTTAYQPRVHQLALTFTPTDAAVSAPNIEYRYRDTILLTDPAGNPVAGLDPNTVLEYPGFPAMPAAAFPGDGFGGEGPGGVRVALDSEGLVVDRVSDEEGFWISDEYGPFLYHFNKKGEMTKAVRPPNSLIPIRNGKEDFGSNNPPRFDPTLVPSPEDPTSGRANNQGFEGLTYAKDENALYTLLQSATINNGGTSDETSRYSTLLKYQLDKDGKNPTLAGEWTVPLPQYTATTGEKFTAAQSSILSLGKGRFMVIARDGDAGRGQSSTESIYRHVDVFSIAEATNFVGKYDGYTDAYAPGGVLDASIKPAEYCSFLDINNNSELAKFGLLNGGSDNNADGLLNEKWEGLSMVPAGREGEYYLFVSNDNDFITQDGHYNFGKYAYADESGFDLYSQMLVFKVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR24</accession>
    <name>U4LR24_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Vacuolar protein sorting-associated protein 21 acc. no. P36017</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR24"/>
    <dbReference type="STRING" id="1076935.U4LR24"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GASFFRY"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="24295" checksum="500D1DE700880256" modified="2013-12-11" version="1">MSSEGAPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCNLPTRTIKFEIWDTAGQERFASLAPMYYRNAQSALVVYDITKPTTLLKAKHWVAELQRQASPGIVIALVGNKLDLAGPPDASSPGEEEEEDRRAISTSEAKAYAEEEGLLFYETSAKSGENVQAVFEAIANAIPESTLKPKTVGTRQGMGQEQPVRVDFDAERGAKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR79</accession>
    <name>U4LR79_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR79"/>
    <dbReference type="STRING" id="1076935.U4LR79"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="193" mass="22572" checksum="6CAAA12D64C533A5" modified="2013-12-11" version="1">MVNLRTQKRLAASVMDCGKRKVWLDPNEMSEISNANSRQTIRKLVADGLIIKKPQAMHSRSRTRALQDAKRAGRHTGYGKRKGTANARMPTQVLWMRRMRVLRRLLVKYRASGKIDKHLYHELYHSSKGNTFKHKRALVEHIHKAKAEKARERILKEEMDAKRAKTKAARERRQERIAEKRKQLMGDLADEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS68</accession>
    <name>U4LS68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized N-acetyltransferase MJ1207 acc. no. Q58604</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935728">
        <property type="protein sequence ID" value="CCX32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS68"/>
    <dbReference type="STRING" id="1076935.U4LS68"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="279" mass="31207" checksum="A9389C25B05B31DD" modified="2013-12-11" version="1">MAAPNPTTEATVAETTPLLSSNPSDPATPAAPGEPGDAAPSAFARSPAASGPAFLLAPCTYTDTPQMASIAASAYLPSGFVQYLNPNAYTYLIDYIRGFHLRVRARMLSSHGHAYKAYLASNPATVLGYVQYTSPHPRSLEPFWRRWWFKARLVWDSWGFKDRSMDSRAVGFLMRYVNPCKKFIKEGEEYYVQSLAVSPRMQRKGVGKALMIPLLEEAEREGRRVWLEASPHGEALYRSLGFILKEKFEMQMEIEETGGGVMVWEPSWLRDGIREGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS74</accession>
    <name>U4LS74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Germ cell-less protein-like 1 acc. no. Q920G9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935728">
        <property type="protein sequence ID" value="CCX32195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS74"/>
    <dbReference type="STRING" id="1076935.U4LS74"/>
    <dbReference type="eggNOG" id="KOG4682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CWLEMQD"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="773" mass="84013" checksum="56B7934F960F4070" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTX3</accession>
    <name>U4LTX3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTX3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4608" checksum="B2D91753FAE4515E" modified="2013-12-11" version="1">MSCLTDIPAPIWVLCTFGFNALHGSLFARALPEIDLITFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTY2</accession>
    <name>U4LTY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTY2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13132" checksum="04D01515E7ACAA50" modified="2013-12-11" version="1">MRLHTEAGIEASGPCVGRNGGAIHHLGLGAVCGGCAGHLFLQDLQFRNLRNGIDIHVPNNTPQLEQLLSRPYSRSELCIKPHSDRKNFKASPYAPSAITPSMDHRKLIQPWNISELDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUD9</accession>
    <name>U4LUD9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUD9"/>
    <dbReference type="STRING" id="1076935.U4LUD9"/>
    <dbReference type="eggNOG" id="KOG4656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNVWEER"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX31571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="25148" checksum="597ED04D5C489012" modified="2013-12-11" version="1">MHAFETLFAVPLKCEACVAHVSEKLHELPGIISVNADLKEQLIAVEGTVPPSKIVSTIQSTGRDAILRGSGKPNSAAVSILETHAPGVKDPVRGLARIVQVSPEHSIIDLSIKGLSPGRYFASVRENGDISKGAVSTGGVWKEGDDVRGDFGEVEVGEDGTGSAFLERKVAIWELIGRSFVVSKKREGWAENEKDTICGVIARSAGVWQNEKTVCACSGKTVWEERKEQVGKGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUF7</accession>
    <name>U4LUF7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_01598</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUF7"/>
    <dbReference type="STRING" id="1076935.U4LUF7"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKITIMM"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX33660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="532" mass="58073" checksum="83BBC941FFA8276F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV54</accession>
    <name>U4LV54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936481">
        <property type="protein sequence ID" value="CCX34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV54"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="18116" checksum="189895E69A193FC8" modified="2013-12-11" version="1">MASTLSSTDSRKTSDTQISKPPSLQDRIKNRLCKLKPPKSPKPRTSEKISSSVFPLNLPYNGSFRKLPNSQGSKWSKKCQGLVVETLHQWMEVPVKYEWQSDESMPGQVVTETVKSRWSKISKMGVMVSLELEEFTYLGGSCRVSSMRRCYWRMTCGNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV57</accession>
    <name>U4LV57_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 4">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 4"/>
    <dbReference type="EMBL" id="HF935745">
        <property type="protein sequence ID" value="CCX32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV57"/>
    <dbReference type="eggNOG" id="ENOG502S2TV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="281" mass="32201" checksum="38D1B9BD7D620E44" modified="2013-12-11" version="1">MNEVKFLAVVPSKPEDVVPFADDLELWPFAVDQMSPVVVHNDKVTLEQLEDGSVTVVENLPPSCQQFYANVTGKTIQLDSDDFEFFEAIHHSVTTEGCIGWNKLKAKAEASGHPFEAQYLRVTLGLNRGNSPGSPFVMGVWPPHHYSSVHSHSNALAVIKVLHGAINSYYYADLDPTKEASQYYRVMEYHKDEVTWLSDRQLQMHQPRNETAKTCVTIQCYQYGDHDHTHYEYFDYIEEGENGQPSTIKAFAPTSDWGFSDFRARIKQEWEQYQKDEREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV66</accession>
    <name>U4LV66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="264" mass="29073" checksum="C613F786F14BC297" modified="2013-12-11" version="1">MHIELVFYPDSNGISDGRFGPTLLFTFSLTHFYLHHNITVYNTMSHPEDIALRSSGDDFSFPVIYRSPKYRNQNLLRSAVWNASIERAGTGTHLTVGAPGQPQISVTVPSPFVISSITVGTTTSKTQTDLYDGTITRTCSTTATINFLDSPRPLQPIAPVSTKRCGGKLYLNPRIQYLDGKVMGIGVLVVLDALCPYTELSKTPVASMLLRRTRLNTRQEPMGSSTLIRSNISTAQEAPLTPNTPWVLVLVLLQAPVVLRIRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVE2</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX34497.1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3589" checksum="4DD2128A75DD12A3" modified="2013-12-11" version="1">MGDPLDFFFGHQLFSPAQSLGTSGTDQSEERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVF2</accession>
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        <submittedName>
            <fullName evidence="7">Similar to Heat shock protein 70 homolog acc. no. Q10061</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCON_13326</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32486.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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        <property type="entry name" value="HSP70_C_sf"/>
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        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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            <end position="925"/>
        </location>
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        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="884"/>
            <end position="925"/>
        </location>
    </feature>
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        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="925" mass="100871" checksum="0D1C007911303F1C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVW1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">PCON_04598</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34922.1"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="26" mass="2843" checksum="A46F5F64B70F39EA" modified="2013-12-11" version="1">MKLLKRAQPAPLSRGFNGMANRPTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW72</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">PCON_14331</name>
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="153" mass="17218" checksum="D1C2CA0B3350A40A" modified="2013-12-11" version="1">MKSMFLTRAVVSCLRTVPHTFIRAASYSAFQNPSALPDSITLGLLLGRQYQVILGATATIHVPAPPSFQTTVPDIPDEILENMPHDSKIHDTIYNMRCAVLAMRWLIHEIESKGPIDASAQLEIDRTWAEMAEVKKRIDELLKIADELYSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYF5</accession>
    <name>U4LYF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to mRNA cleavage and polyadenylation specificity factor complex subunit pta1 acc. no. Q10222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYF5"/>
    <dbReference type="STRING" id="1076935.U4LYF5"/>
    <dbReference type="eggNOG" id="KOG1895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AREMCLN"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="86"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="720" mass="80055" checksum="3D0BF0FDD8175A26" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTR2</accession>
    <name>U4KTR2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935195">
        <property type="protein sequence ID" value="CCX04273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTR2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5735" checksum="D5796155E4858A56" modified="2013-12-11" version="1">MKLRESFMRFRQALRKYYQLHLGIGQTECRDGPFIFIDTNQGIWQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU84</accession>
    <name>U4KU84_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_02477</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU84"/>
    <dbReference type="STRING" id="1076935.U4KU84"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="473"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX04507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="942" mass="104131" checksum="36027C284E0E6489" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUW3</accession>
    <name>U4KUW3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935210">
        <property type="protein sequence ID" value="CCX04601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUW3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="150" mass="17125" checksum="E9E1A13C2E6F6C0B" modified="2013-12-11" version="1">MNFSCKKHYRITITFNSVATRISDTAAETPLAYEMEPDPAVLEDPTNDSYGIHLYISMLVIVDDYVMEIRHRYHNTPIPSIVNPEQLPVLLPDNEFDEMCDEEAGVLVLKLDQPEIDRLNLHHVAMEGLYEAPIKEPRMVLDVGTGYGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVC8</accession>
    <name>U4KVC8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_05060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVC8"/>
    <dbReference type="STRING" id="1076935.U4KVC8"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FELWTVF"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="118"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX05473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="416" mass="45526" checksum="0ABD5D65FD684902" modified="2013-12-11" version="1">MAAPSWQSSMGFVERLAVVEKIATALSLSNPQILRAQAMSMAQQVEDGILSRAYSKEDYIRLWTAKLAELQAAAASKTSSEAVPDSPTVSLAGSSGSGSDINSHFFHQQEQVESIGPYKTATHIASGLFSSIYKALLESSDPHKKQLVALKVTSLSSQQPPHNSKQEAHIINSLPPHPNIIKLLDTFTLPPSTFVLVLPFLPHTLASSLEKRLVPTQWRALSIIRDVLSGLAHIHKHGIIHRDIKPSNILFLACLGPAIIADFGIAYTPGGEEKEDDKITDVGTTCYRAPELLFGHRGYGRGVDMWATGCVLAECIRGGEALFEAGDLGSELRLIASIFRTLGTPNSESWPETKHFPDFKKIQFHQMPAKPWEELLPNGTPLMRDLASKLLRYESGDRISAEEALKHPVFEGVPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWH6</accession>
    <name>U4KWH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWH6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11470" checksum="53434D0FFD3AE647" modified="2013-12-11" version="1">MASKPPQSQWCVKITKKSCITLPVDLKTVREWFGENTDRIKQDGPDSWLIAYDSEDHCREHIDFAEENTDICDFVHVEVVYTLWAITENDLLLDVGSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXI1</accession>
    <name>U4KXI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXI1"/>
    <dbReference type="STRING" id="1076935.U4KXI1"/>
    <dbReference type="eggNOG" id="ENOG502S62R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="16741" checksum="E591E302DB8ABCDF" modified="2013-12-11" version="1">MSSKMFRPLLRLLKPSIPVSKKPMATMTDLPQRLNIHHTPLSLHSLNPITGFARDGYCHAPSSDPGNHSIAAIVTDEFLNFSKDRGNDLTSIGLKGGCKWCLCVNRWMEAVNAYGKGELSKEGVPKVVPEATGLRALEGTTKEELERWKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXM8</accession>
    <name>U4KXM8_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Dynamin-binding protein acc. no. Q6TXD4</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_06504</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KXM8"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QHCAEKE"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1132"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="484"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1011"/>
            <end position="1124"/>
        </location>
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        <location>
            <begin position="1696"/>
            <end position="1861"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
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        <location>
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        <location>
            <begin position="609"/>
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        <location>
            <begin position="641"/>
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        <location>
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        <location>
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        </location>
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        <location>
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            <end position="853"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
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            <begin position="1034"/>
            <end position="1050"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="1074"/>
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        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
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        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
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            <begin position="1711"/>
            <end position="1730"/>
        </location>
    </feature>
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        <location>
            <begin position="1801"/>
            <end position="1810"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1820"/>
            <end position="1837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1935" mass="213813" checksum="AE56FC0CE68AA62C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXZ1</accession>
    <name>U4KXZ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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            <end position="472"/>
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        <location>
            <begin position="449"/>
            <end position="467"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="510" mass="57281" checksum="7C5ECFD9BBE6F8F3" modified="2013-12-11" version="1">MAETPPPYCNSAASLGESTKAFFLHLSQDAGQSRSSLDSRDSFSTLDREIAAPRSLLDLTPQPTAGNTFNSDFSTDEKDCTTINVTSISSTSSDSEGAPCFEPATPASPQLFFTSVHYQQWRSEQTLRQCASARYIEEPKKAANDYYIESLRAATIKQYGVRTYNHAMGLPPPKARRQKPLEMSRESMITDSAEPKIFQSAKPNISGFNAISDGNSQNVYEVLCGLRKKFQEEEEQRRLEEEMGERQKEYPAFTMCLEPEEKEGDKEVNIESLSSMVSMASLVTMYDAKRASTASTDPYIYVQTRLRDLAPAENVTEPPTHPKSPPAWKDIMEDNPTWRRISMRPQPKAERVLGLTPSAHWRQPTVYTALIEEERRGYEHENTRRDSMVISKGTVWIPPASTFDQMPIVQMTDKAHASQPKKADKRESSLSEKLRKKKMSTSSTVESIDTDKVKHKSTNDSPRERKSGGILARAKTIKWGRISLGKKRGSENSAFSVECEGGRHDLYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY76</accession>
    <name>U4KY76_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">PCON_06508</name>
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    <organism evidence="1 2">
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4KY76"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9679" checksum="C5AE284258DAA513" modified="2013-12-11" version="1">MDHLNPKLMDRSRNKSTIIDELDMIPRIIRMRERMEAMKLQIIEAKRRREAMASPIKRGEEWSMKSGDDKAEVINRNEVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY82</accession>
    <name>U4KY82_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Kyphoscoliosis peptidase acc. no. Q8C8H8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY82"/>
    <dbReference type="STRING" id="1076935.U4KY82"/>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="1">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="309" mass="35861" checksum="A4276703A8613306" modified="2013-12-11" version="1">MPTCLRHRCFAKVDAHAAKRHTKSSLEALAQSLTSPFRSHTDKARAIFTWLHHNIAYDWKEVQSGFMKSLTAWEVLKAGKAVCAGYSKLFQALAICSGMQAEYVWGHYKASALEEGKVRREGKARITHAWNAVRIDKGEWWLIDCTWGAGYLSDNDTKYTKRFNPEHFVATPKEFGRRHWPNDERWLLFDTTWSEYCEPDKQGPVIYTGLSEIGFIKRTKYIKPRRFGGSGRWRIFVYIGETVNKERVVVMTKEGKRWTATIEVRRGETVCVAYVKLWHGRCGKGLSRTEFLNGIGKVAWKWQDMVRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ89</accession>
    <name>U4KZ89_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Aspartic proteinase yapsin-6 acc. no. P40583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ89"/>
    <dbReference type="STRING" id="1076935.U4KZ89"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRCRKER"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF101">
        <property type="entry name" value="HYPOTHETICAL ASPARTYL PROTEASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650982" evidence="4">
        <location>
            <begin position="26"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="49"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="612" mass="66529" checksum="06B565357F993310" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0F5</accession>
    <name>U4L0F5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_08161</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="HF935420">
        <property type="protein sequence ID" value="CCX08568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0F5"/>
    <dbReference type="STRING" id="1076935.U4L0F5"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMVNTDA"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="86"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX08568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="339" mass="37507" checksum="9A6860BBD3FA66D1" modified="2013-12-11" version="1">MTIDMATDLSSLFVLLRETPTTTILTALVGLLTFGLASAYFLLRLIAHHPRPSTEKERFYRTTTPDGIASYPLPPAFTTDASCYLSVIVPAYNETERLPAMLEEAINYLRTTLDSWEILIVDDGSKDRTCAVALEFADAHGLEQDQLRVISLEKNRGKGGAVTHGMRHCRGEYAIFADADGASQFSDLEGLMKDLKRVEKEGYGIAVGSRAHMVKSDAVVKRSFVRNFLMHSFHTLLKTVGVRDIKDTQCGFKLFSRKAVKAVFEDLRTEGWIFDIEILLLAGYKGIPVVEVPVNWHEVDGTKVNLVSDSIRMARDLGVVRAGYAVGVYTIGRGGPGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Q9</accession>
    <name>U4L0Q9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C26H8.11c acc. no. O74793</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Q9"/>
    <dbReference type="STRING" id="1076935.U4L0Q9"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DEHIRNC"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="163"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="266" mass="28509" checksum="6810BE1D9168BAA2" modified="2013-12-11" version="1">MTPLFTRLRPLSRHYATAAAATAPVGPSRLVYGTRVALALVTVGGLSFFGGAYTLKQFIPGSGPIDTELLHLPGSPADTASVLASAAVIAASPHYRKLKADDKWVEADDVYSHLSADARKTKLLSGTLWGHRKVSANKVFFSVDGKESISFLVLGTALCGHPNVVHGGVLATVLDEALGRLAIRQFPDGGAVTARLEVKYRAPTRAAHGIWNRDAYVVVTTRVAELAERKCKVVGEIRDKEGKLLVQSEALFVVPKGWKPRPLGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L102</accession>
    <name>U4L102_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative lipid phosphate phosphatase 3, chloroplastic acc. no. Q8LFD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_05331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935272">
        <property type="protein sequence ID" value="CCX05744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L102"/>
    <dbReference type="STRING" id="1076935.U4L102"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="111"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="47990" checksum="D6E61C702EC61119" modified="2013-12-11" version="1">MANTVNKRQFVMRMLGTYLLDWIVVIGTVAFAGSTSIWVVPNTRPFSLDDISIQFPFQTAAKIPTWLLLVCSVLIPILVILLLTLALPSPRPLTGRLNGFKRRLYCLNTAWLGLGFSLTMAILITNGLKNLLGRPRPDLISRCHIDPNDLEAIKRWTIGPGKLLDWRICKTVSKGSALAGALNEADIRDGFRSFPSGHCSMSFAGLTYLSIFLAQFVFALPLAHLNRHSNRPTSSPVMRSGRNKRTDETDTPLPRFPIMLALLICGVPLLLAAYIASTRYSDYRHHTFDILAGSILGLVSAFVGWRWYGAWCCAMGDGRVYGLAERLRLREEEEAREADLEAQAVATKGSVYAQPTAYMGNTYAQYQEGNPQAAEEMQPMAPAQARDLGNRQRLMEENSRRERRSRRSNSQGQRSRPTTGRERERERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L168</accession>
    <name>U4L168_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935429">
        <property type="protein sequence ID" value="CCX08759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L168"/>
    <dbReference type="OrthoDB" id="10442500at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651820" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="15806" checksum="20C4B115C8A5A57A" modified="2013-12-11" version="1">MKLSRRNNLTFLLALIVALPSMALPAQPKLHASNMDVNTGTLMNATLSHTNFTLVIETPKKPSHPFNVTLPFESTNSTKTVLLQVQTEGAKVIEKEKGTVSSAATTTSVKEWLAWWRMNMEIEGRQKLRYKWKFRGRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4L186</accession>
    <name>U4L186_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935394">
        <property type="protein sequence ID" value="CCX08179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L186"/>
    <dbReference type="STRING" id="1076935.U4L186"/>
    <dbReference type="eggNOG" id="KOG0359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="539" mass="58727" checksum="CF4B4891E3260771" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2I0</accession>
    <name>U4L2I0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2I0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5526" checksum="D3EFE62C07B13023" modified="2013-12-11" version="1">MLRCIESQVSRWPQATSSRCEFFRLPMFITINMATSIFFYPSANIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L345</accession>
    <name>U4L345_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_02422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="HF935205">
        <property type="protein sequence ID" value="CCX04465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L345"/>
    <dbReference type="STRING" id="1076935.U4L345"/>
    <dbReference type="eggNOG" id="KOG1504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="13">
        <location>
            <begin position="45"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="12">
        <location>
            <begin position="195"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX04465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="360" mass="39044" checksum="6B98DC07AD76FE7E" modified="2013-12-11" version="1">MSFSKATLRVVSKPIRSSFQPLTSFRTIVHPATMSTPSTSPFAPRHFLSIADLTTKELTTLVREAARAKHAIKLGNIPAGLQGTMTGKTVALMFSKRSTRTRVSTEAAVVTMGGHPMFLGKDDIQLGVNESLYDTSVVISSMVSCIVARVGAHSDIAELAKNSSVPVINALSDAFHPLQAVTDILTIQEAFPKLEGVKVAWVGDANNVLYDLMIACSKLGIHVSIATPKEYPVDPKILEIANQCAATSGSKIECFNEPEKAVKDANVLVTDTWVSMGQESEKALRLKQFAGYQISADLAARGGAHPDWKFMHCLPRKPEEVTDEVFYSPRSMVFQEAENRLYAALAALDAFVVKKGDFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L382</accession>
    <name>U4L382_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L382"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8307" checksum="02CB1507D37B4E85" modified="2013-12-11" version="1">MHALFQATANQDITRELRRPGSNGSHAPMPLRFNYHSRSVWDEEILAYLMRRFILLVKLLGNHTVFSSGLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3E7</accession>
    <name>U4L3E7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3E7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="4107" checksum="67676A6444628BD4" modified="2013-12-11" version="1">MQCDRLYCCQHRPTFFLCTVRRLRTVCFGDPLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3J5</accession>
    <name>U4L3J5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Lipid phosphate phosphatase 1 acc. no. Q9ZU49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3J5"/>
    <dbReference type="STRING" id="1076935.U4L3J5"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="187"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="420" mass="46593" checksum="68D2537E81A00478" modified="2013-12-11" version="1">MFERIFNQPQSHASSTNGLASATDAKIAHPNNSHNPIREKSRRAQDLEAQGVQDADGWTDPYGPAPGFIGWFKLYWHDLIAFIFLAGLSLWLLMWSPVPYKKYFAVSFDPSSPTSETVNAEFGYPKRRQYVPIIGDALLAVFTPIVTIIVINCLGIGTYYPLGMRVPKLRRGGTLFLKRGSFWNVNNGCMGVIYSVMTGATIQIIVKLVVPGMRPHFLTVCDPQIGPDTKGEGYKGMYFTTSICRDHNDPKRMDEIANALQSFPSGHSVAAWAGLFYLSLYLNAHLKIFSNYHPSYWKLLLFVMPLVAATLIVGSLTLDMSHNWYDIVAGSFIGIMMAILSYRMCFASVWDFRWNHVPLRRGANRGREEVLGLGYTQQEMVDWCGGCATRRAGWGVATGVACGAPGDSTAAASVLHTIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3N2</accession>
    <name>U4L3N2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935519">
        <property type="protein sequence ID" value="CCX10188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3N2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="9755" checksum="86002BCB75AACE2A" modified="2013-12-11" version="1">MQRTQCPQKQIIRGIRIINQGRPTLCSATLCHSARAKRSPSVLLPPVLRSTPCYPGHTYRNVIAFNCRIPVANVISIRSWTAGKTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3X4</accession>
    <name>U4L3X4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 40S ribosomal protein S17 acc. no. P27770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3X4"/>
    <dbReference type="STRING" id="1076935.U4L3X4"/>
    <dbReference type="eggNOG" id="KOG0187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKRIQQG"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="144" mass="16677" checksum="420C1E2EA7248E7D" modified="2013-12-11" version="1">MGRVRTKTVKKSAKVIIERYYPKLTLDFETNKRICDEIAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEISALDYQNNTDSGSLEVDADTKDMLKSLGFDAIPVNVVTVSQQQDQGNRRFRGNRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L488</accession>
    <name>U4L488_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L488"/>
    <dbReference type="OMA" id="YDNAPEN"/>
    <dbReference type="OrthoDB" id="5428515at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651278" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="246" mass="22661" checksum="478A252A9DA17C06" modified="2013-12-11" version="1">MKASVVLALTLAAATYAQSCEDCNNLTALRECSPVWRAAVGACQAAPCNHQFPSNPYEPCDRAAAASAAAIAAAASSASATAAQASESAAAAAASSASAAAAQASESAQAAAAQASQSAMEAASASAAVAISSVQSSAASEASAIVGGANSTINDAQNSASSAASSVGAQITDAASGAASNISSIVSSASGAAGSAASSIASDASNAIASATGAAASATSQAANSAAGVQASIGAVAMAVMGLFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Q9</accession>
    <name>U4L4Q9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Inversin acc. no. Q9Y283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Q9"/>
    <dbReference type="STRING" id="1076935.U4L4Q9"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASHELIM"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="322"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="741" mass="84365" checksum="EF93AC3B56F654F8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4S7</accession>
    <name>U4L4S7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4S7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10612" checksum="D75BD13C540DD966" modified="2013-12-11" version="1">MESTKITSDENFYRSAADCLLQRLLLIRTQSCDPANHLVCPCYPMIHNAEEEKKINKKNEDEIVQAGPGLVTVINEVVEVTITIQAPAPQTSDQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5C8</accession>
    <name>U4L5C8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935661">
        <property type="protein sequence ID" value="CCX11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5C8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8445" checksum="2A21132E32EAE246" modified="2013-12-11" version="1">MTSERGHGTARLLDNQSTLPMFLMSSRSRSDMQGIPVQFVDHAPAGYTHDSYQHVPMVMPVPLQMCYYFGILPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5E2</accession>
    <name>U4L5E2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ESPKKYV"/>
    <dbReference type="OrthoDB" id="10615777at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126644" checksum="C1B716D2CE560757" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5I9</accession>
    <name>U4L5I9_PYROM</name>
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        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF935614">
        <property type="protein sequence ID" value="CCX11408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5I9"/>
    <dbReference type="STRING" id="1076935.U4L5I9"/>
    <dbReference type="eggNOG" id="ENOG502QW74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LRKPPNH"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000020">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
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        <property type="entry name" value="P4HA-like"/>
    </dbReference>
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        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="314"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX11408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="446" mass="48644" checksum="E6439C0F29D767BE" modified="2013-12-11" version="1">MGKASKQRKARTKAATAASAPYPPTPLSPTSSSDTEGISSVDLAITTETLEALLAKPALLKSAAHKNLRAMIHKLHAAVQGGEDELVIALRAGEHEHARNLLATIKNPKLGALQRWVRECDAINDGSDECWKTLEAIIRTTTTRDNAIGALARFQPWRPETGEEALHIYRDVKLGKICSREEADHFKASFRVLHTIPAAERKPPNLHPAIIWSSNDNTIPFTPTGDITAIPIPSVPNAIFLQNVLSQTTCRQIIAAAETMGFTPDQAAAGSATELASVLAHNFYWMADEAFCTSLFERVKPFLPATVKGLPVRSINRRFRCYRYVPGAVYRPHVDGAWPPSGITSKGEYVYNASDPEKPEYSRFTFLVYLNDEFEGGETTFFVPAPGEGLEARGVKPMMGSVVVFPHGDAEGSLVHEGTGVTKGAKYIIRTDVVYEVPKSGRAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L602</accession>
    <name>U4L602_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L602"/>
    <dbReference type="OrthoDB" id="10313138at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651150" evidence="1">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="17100" checksum="952FE1E0E9C505DE" modified="2013-12-11" version="1">MQLLILITPLLLLAPTIQAAIYLKNPAIKPQCSPGPDDRLTDIKTVDKWSKELKKRGGWCCAGQKWKKCNRIVAGNPRREDLATLCIMPSSPIEETCAPCTKVADLMVQLMKVCVYKGDVAGDGGFLEEGKMKVQLLLFEPIIFNPPFPGSPMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6R8</accession>
    <name>U4L6R8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Splicing factor U2AF-associated protein 2 acc. no. O43120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6R8"/>
    <dbReference type="STRING" id="1076935.U4L6R8"/>
    <dbReference type="eggNOG" id="KOG1548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTDFRFG"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000329">
        <property type="entry name" value="splicing factor U2AF-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
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        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="43432" checksum="1D10BC3F5C59BBED" modified="2013-12-11" version="1">MLTPPPNTGSLGFPTSIEEFQNDPRISWSRLDNKWSLETEEGAEWHFEDALKRWVPVLDESLAEQQQKAYAIAGVDESEPAIKPKEKKRKNYTGEGEDADEAEEKAKKKAKPEKKPQAPRQNTAVYITNLPLDTTEAEIKDIFSKYGVISEEIDTGKPRIKLYRNEDGTLKGDALVIYFRPESVNLAINMLDDSPLRIGGGGIPIRVQAADFSYKQQKEVPTQTSKKEKKKIIAKTQRLNNKLADWDDDDPAAVKRAEPNKFGGKVVVLKHMFTLQELEEDPTALLDLKEDIREECEKLGEVTNVVLYDQEEDGVVTVRFKEPTTAMSCVQMMAGRFFAGQQVEAYIADGSEKFKKHTKNVETAEEEEAERLEKFGSWLESEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>U4L6S2_PYROM</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6S2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6237" checksum="69522DB40308290A" modified="2013-12-11" version="1">MQLQALTKDTYNLGCRCWWWVVKASVGGGGLSSFSLAACAGGLKVGLGDGCGRRDTEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L702</accession>
    <name>U4L702_PYROM</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:microtubule minus-end binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GCP_N"/>
    </dbReference>
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        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="268"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="590"/>
            <end position="826"/>
        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="891"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12894.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="891" mass="100386" checksum="CE1682707E39CE2C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L796</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_08162</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935420">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="31970" checksum="8621B44DE2E1411E" modified="2013-12-11" version="1">MGVWACCDTMQTMTACPSGYASCNRRSWFNHRDGCCPSADECLLSGIPSCSARNNFIVPITPSAILIPRTAQAYDLPPPAEPSTISKEVYVPVEPIASKSATSESPATKSNPPILTLQMPTSPSPSSKTASATPDPVDTPPNTLIMDLLSPTSLSTPANPMLLIGTPLPKDSPASTSLTTAMQAGIGIGLFLLLVGIMTALCFLYRRRRSHRGQTDTARGYAEMQGVDNRISRTELRATSTEAVEMAGCAPADSDERTRGRGNVVVALRELEDLVVARRGREVELPAEKASPTRSWLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7M6</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08512</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7M6"/>
    <dbReference type="STRING" id="1076935.U4L7M6"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38877" checksum="2C6D5D6034B91C4E" modified="2013-12-11" version="1">MVSSAPVYTTADPVTIPLSSLERGDVSSESLLSAFGPNSLGIIVVNHLPARFSELRTRLLSYASHIASLSPAELAKLEAPDANYLVGWSCGKEKLSADGRVDTLKGSYYINCAFYKDPSLDGAEGKEKYPEFKEYTAGNIWPELEGYEDCMKEMCTLIIDTAVLVARACDRYAEGEIEGYEKGYLEKVVKTSTTTKARLLHYFPPTEEMAAEDLDTWCGTHLDHGCLTGLTSAMYVDEVANPPDLSKGVELPELEGGPPDKEAGLYIKDRNGDVVKVGIPREGLAFQTGEALERITQGKFKAVPHFVRGMQPSKGVGIARNTLAVFTQPNLYDMVDKEMDFAQFAKMVVEKNTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7S3</accession>
    <name>U4L7S3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7S3"/>
    <dbReference type="OrthoDB" id="10554371at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="178" mass="20974" checksum="735DB49B6D91B123" modified="2013-12-11" version="1">MRDMVYKIKMFKKATYILPHVLMQRAWVMLSTWNIENGKLCGFIVSMQRPRYCEEKDWNVIFKPWPRLPGKGLEVDSPVTEVRLITEGCDENRTYLFQQLDKYNPTCDPRKPNLIAMTHSGAWKNFNEIAMQDIMHQFESISRIKMSKILGYIADCNHCEMSPEHPSHPPSFCSYTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8R7</accession>
    <name>U4L8R7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935291">
        <property type="protein sequence ID" value="CCX06509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8R7"/>
    <dbReference type="STRING" id="1076935.U4L8R7"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQMAKDF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX06509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="202" mass="22526" checksum="F664D229A1E70D03" modified="2013-12-11" version="1">MVTPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIEQDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVFDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMADKKVVEYSVAKEFADSLGIPFLETSAKNATNVEQAFLTMARQIKERMGSTAVNNKPTVQVNNGQHVQQGSSSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L934</accession>
    <name>U4L934_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L934"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6357" checksum="B913E629F220AD43" modified="2013-12-11" version="1">METHIPWLQLPHLVLSHDRYIVSNLSILHRASSASRYPLSTCASAASATSRKLTRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9G4</accession>
    <name>U4L9G4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Demethylmenaquinone methyltransferase acc. no. Q9RRT0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936257">
        <property type="protein sequence ID" value="CCX15738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9G4"/>
    <dbReference type="STRING" id="1076935.U4L9G4"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HESPLNE"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="329" mass="37447" checksum="5782CF4F47BCDF79" modified="2013-12-11" version="1">MLEVDPSVLERPDDEDYNSAGYDTSTASLSSSVHQYLFEHGRRYHAYYGPDKYLMPTDEKEQARLDLHHEVMRMLWDDKLHESPLNEPHRILDIGTGTGIWAIEMADQYPMAEVIGTDLSPIQPEWVPANCRFEVDDAMLEWTFKDESFDFIHGRNISSGVSNWEHLVSEMMRCTNPGGYIELCEYAIAVFCDDGTMKPDNGAKIYIDHMRDAMKKMGRPPPDPQFMKRLLENAGFEDVHSLEVKEPLGPWPKDPKQKRIGAMSLLNCETGIESYAMAAFTRVLGMEAEKARSICDAGLSATRNKNNHMYGKYYRVYGRKPKGTGVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAE2</accession>
    <name>U4LAE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Heterokaryon incompatibility protein 6, OR allele acc. no. Q9UV10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAE2"/>
    <dbReference type="STRING" id="1076935.U4LAE2"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF14">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="223"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="689" mass="79460" checksum="5872EB57B915FB05" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB16</accession>
    <name>U4LB16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein y4xN acc. no. P55706</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB16"/>
    <dbReference type="STRING" id="1076935.U4LB16"/>
    <dbReference type="eggNOG" id="ENOG502RX6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLIAYIQ"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="273"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="424"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="595" mass="65970" checksum="8CD595838189AE81" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB29</accession>
    <name>U4LB29_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to V-type proton ATPase subunit H acc. no. O14265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB29"/>
    <dbReference type="STRING" id="1076935.U4LB29"/>
    <dbReference type="eggNOG" id="KOG2759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="5">
        <location>
            <begin position="347"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX16346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="463" mass="52158" checksum="8A5D100CF10DB7D0" modified="2013-12-11" version="1">MSFDGQNVLDEYKSLIRNRAISWESYIRFQLVTAEDVDKIRAIDTDKARRVQIVERDAKGYAQLVLGDNGILRKSSSENKLDVVQYILTWTGDLLDDVPSFANALLALLKPFEFLLQLLQQMPDPRVPLLSASILTTLIATSLTSSPDTPSAELKDALSKFYKYLSTVSKSGDQDQQDLAIRSYVALLRTQQAREIFWNMKEDTVSPLAAILEAATGGAGEAGEYARASGAVFQGGVPLQLLYHVLLVIWQLSFEETVAEEINDFCDIILPVTVIIRNSIKEKIARVSLAFLANLVTKAPENSLPPLLVTNVLPHLQTIQSRYEGDPDIAQDFETIISALTAFQLEQTTMSSYRMEVMTGHVRWSPPHRNENFWKKHAYELMQDIELIKRLSALLDSTDPQVLSVACNDISYLVREGRDAPGSKRRWEELEVKKKVMLHMANDDPEVRYEALKAVQMFLQTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBK4</accession>
    <name>U4LBK4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBK4"/>
    <dbReference type="STRING" id="1076935.U4LBK4"/>
    <dbReference type="eggNOG" id="ENOG502SQYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYESPST"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="33168" checksum="E633B9363ECF219E" modified="2013-12-11" version="1">MNHHHAYYQTAPVIASMPSVSPHHYQQRPATTRVSSNTEFRGSTNPDEDWTKISDLAERRRIQNRIAQRNYRKKLKRRLEDLERRAASRSVSPNEDTDGRSTRESSAEQPLHSPPPSSEPHLTHSPPRDSYLSGGYSSSIGYQSHYRTASGSQSPSFAPLYASSEQSNYGYYPPVSAAMSGSPQLPSINDHSSSQPAYSYSYSQPTVSSMLDATCGPVTSGPEHSYGLPLPSARLSGYSGVAPEYALPKTAPAVYDTENPFYLTYSSLADTPEPSYFSTNYYNQHQHHDHASPTIKQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBW9</accession>
    <name>U4LBW9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936505">
        <property type="protein sequence ID" value="CCX16727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBW9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7287" checksum="F113458FAF85B888" modified="2013-12-11" version="1">MLIGPCAVALIETPHSYLLEYPALSAGPGCCRHWFDHGVDVFPTVSESTNISVPITRVPHRADVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBX0</accession>
    <name>U4LBX0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBX0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="16293" checksum="E6D1BCB6BD73193E" modified="2013-12-11" version="1">MARFYPKNPPSIAPFQRSPISTQSRHLKHRRYDLRNHPPHRLGRRQTGSSPQLPRDSRSQRRIPLPRGTPLQLALRPSCQGIRHQVHCLRRHRIRPSLRHRRLADEEEPVNVLRLQKKSIMGYRLEETCSLHSMLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC64</accession>
    <name>U4LC64_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative transcription initiation factor TFIID 111 kDa subunit acc. no. Q09813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC64"/>
    <dbReference type="STRING" id="1076935.U4LC64"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFINYYR"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="402"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX17423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120381" checksum="D9B3D6BBE29456A0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCC0</accession>
    <name>U4LCC0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_07065</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCC0"/>
    <dbReference type="STRING" id="1076935.U4LCC0"/>
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</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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</entry>
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    <accession>U4LD91</accession>
    <name>U4LD91_PYROM</name>
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        <recommendedName>
            <fullName evidence="3">amidase</fullName>
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        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
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        <property type="protein sequence ID" value="CCX29813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LD91"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="80"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX29813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="571" mass="62569" checksum="4452FAF5298FE032" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDP0</accession>
    <name>U4LDP0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Vacuolar morphogenesis protein 7 homolog acc. no. O74509</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDP0"/>
    <dbReference type="STRING" id="1076935.U4LDP0"/>
    <dbReference type="eggNOG" id="ENOG502RXJQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QASVRSW"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="1">
        <location>
            <begin position="293"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="357" mass="39928" checksum="1169AA2BAB443AB3" modified="2013-12-11" version="1">MSLQLTIPSSSEQHSPGKPYTQYHILVRTPIRSYTIKKRYTDFLALHDALTTHCNSPPPLKPPPKHWIGSTLGNPSRTEERRSALEAYLYAINNSVDSRWRDSSAWRSFLSLPASWTNNAAAKSPQLYTGSLPNGPITDPTLWLDNNREMKQLLHDARIQLNKRDETTIASEQRDASAAAKRCLVKASAIVTALDQGIQQMSAMKDKPLLEGEIRRRRDLVAAAKQERDGLEDLANKQSTARRSAGVSDVHANLTAPKNGNGRITRVLGAPATLPETAETRELDNSAVLQMQNRILREQDQGVGVLLDIVKTQRNMGQQIGQELEIQTEMLKQVDTDIDRVDRKTRGARSKAEWIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE06</accession>
    <name>U4LE06_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE06"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="163" mass="17227" checksum="A65CB448E093A7AA" modified="2013-12-11" version="1">MAQQPPIRKATPIPRPVYNALLSPWGYYFRPDFTKPFSSYTAGYTSSYTSPPAPVTNSPASNGSGSGSGSDSSSPSPSDYNADRDTSSGGTESETDISICDEVEDSASSGVGCKTSKTGGIVAPKPILKTRTTMVRTKSTKMTNARVRFNIKNEGAPKMVRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE33</accession>
    <name>U4LE33_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE33"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="5748" checksum="23D7D733BC7AFE1B" modified="2013-12-11" version="1">MYKVPQTGGPRVLDATGRTASVPRKTRGRSDNLESSLSSEGEASWGGLASGWPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEJ3</accession>
    <name>U4LEJ3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_12748</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEJ3"/>
    <dbReference type="STRING" id="1076935.U4LEJ3"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Malate dehydrogenase"/>
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        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
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        <property type="entry name" value="MDH_euk_gproteo"/>
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    </dbReference>
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        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ldh_1_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDH C-terminal domain-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
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    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="335"/>
        </location>
    </feature>
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        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="56"/>
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        </ligand>
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        <ligand>
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        <location>
            <position position="110"/>
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        <ligand>
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            <position position="117"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="339" mass="35823" checksum="5749ACB277F212F5" modified="2013-12-11" version="1">MFSARTAFSAVQRRAFSVSAQQNSKVTVLGAAGGIGQPLSLLLKLNKRVTDLALYDIRGGPGVAADISHVNTKSTVKGYNPTPEGLKAALEGSEIVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAEHAPNANILIISNPVNSTVPITAEVFKSKGVYNPKRLFGVTTLDIVRASRFISEVKNTDPANEEVTVVGGHSGVTIVPLLSQSNHPDISGEVRDALVNRIQFGGDEVVKAKDGAGSATLSMAFAGARMADSLLRASAGEKVVECTFVDSPLYKDQGIEFFSSKVVLGPEGVKEILPVGKVNEYEQGLIEACLKDLSKNIVKGQAFVKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LET9</accession>
    <name>U4LET9_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_12848</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX13255.1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11668" checksum="6A02B3443FD8B09B" modified="2013-12-11" version="1">MPPLPASSVFPPLIPDGYTLFFYIIGGLIVLNVAVTAIHFFTNAPLFIKYMFYTTRFIVTAPYRAWKYICRVAEKEQEDAMAHQSQGDELAQSAAAETWPNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEW0</accession>
    <name>U4LEW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="27228" checksum="16CEDCD212BFCA45" modified="2013-12-11" version="1">MTGSEPNADVLEGGASQAVDQSSLNKGEKVLHLDCWSVKPSDLVPDSSTEPKPNNKKYKKHKKTSRPNDDHLWFTRSHVYMSGKRRVSPVDETVGNKRYKNEKITNTNQACDEGHEGEYKEEHNEEHMQAQSSSGNQPLHPESFDASKEHEERGYAADSNSSDSNSNDDSNKSNSNDNNSNENSNDNSDDNSDDNSDDSSGSDPDSDDEYESPFEMRRRMMKEYYRQHHPYFRGAYPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFA6</accession>
    <name>U4LFA6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_08757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFA6"/>
    <dbReference type="STRING" id="1076935.U4LFA6"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPFENAF"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
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    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX30558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="324" mass="36758" checksum="BEB5AFC59C072314" modified="2013-12-11" version="1">MNAGIRSSRPLGMLLKQHLRQLPRCFATSATSAEASTDVPTASVNPYRVATSVVLSRPPMLTQELHPFEESFYFYQRRLNQRLALPFTRYFYIKKGTPADMEWKRKQKAAGGYTGFGESAWKDELKVKDNDQKEPDFGYKRLVKTTITGEDENLELNENGELPEGGKSRFEMPLSRITEADKKKDYRSLDRRGDRTLYFLVKSKGNAGPTWKFPVSPIAGRENLKEGAIRTLEQAAGVNMNTWFVGNVPIGHYTNPFGPEYPAPAEGLTAEKVFFMKARIMAGQANLENNLLGLEDFMWLTKEEIEEFAGDQYYKAVQHMLASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFI3</accession>
    <name>U4LFI3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFI3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012519953" evidence="2">
        <location>
            <begin position="16"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="542" mass="59087" checksum="096EB4186272E509" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFS0</accession>
    <name>U4LFS0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_08564</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="OMA" id="NDQENQC"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="122"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="22">
        <location>
            <begin position="869"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="1169"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1053"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1138"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1230"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1139"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1152"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCX30367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1293" mass="141985" checksum="8DD60DA9D44B5733" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG89</accession>
    <name>U4LG89_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX14999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG89"/>
    <dbReference type="STRING" id="1076935.U4LG89"/>
    <dbReference type="eggNOG" id="ENOG502S0H4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKQIVHV"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652271" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22893" checksum="94A2B104255BAF62" modified="2013-12-11" version="1">MKWASVFLAFAAGIALAEPIPKAPNSGAIEPDPSQVWIDGVTYGGSGCPQGSASVSLAPDRKSFTVILDQYIVNIGPGVSITNARKNCQLNVQLHYPGGFQYSVYSSDYRGYVQLEKGVTGTQKANYYFAGNTAQSSAEFKVTGPISQDYLAHDEIPFTSTVWSPCGEFVALNINSQIRVDNTANTKGNGLMTTDSIDGKVTFQVGVQWKECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGA2</accession>
    <name>U4LGA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized protein C4G9.14 acc. no. Q10244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGA2"/>
    <dbReference type="STRING" id="1076935.U4LGA2"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWVPVFQ"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="180" mass="19929" checksum="34600598548A9603" modified="2013-12-11" version="1">MSPVIEATVQAATLSAVSNLLAQSIKSYSESKPFVFDFTPVIHFAVFTILSTPPNFLWQLQLESWYPSQVPVEQKIEKENTVVKTKLSKSNTIKKFATDQLLGAPINTVLFLAFMGYMRGFTGDALKTYVSEEFWPLTSAGLKLWPAVSLMSFAAIPADKRVIFGSIIALGWNIFLGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGA7</accession>
    <name>U4LGA7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGA7"/>
    <dbReference type="STRING" id="1076935.U4LGA7"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32589" checksum="F2F81950B72B058B" modified="2013-12-11" version="1">MFCESLPPSRTTQPSQPIGTPFLSARTYSNQYDDHLNAATFDLDNTTFDDNYLFGSDFTLFDNVELNKSLVTPDTTVQSFDSFLALTQAEDFLDLSELLDNSPTSSTISPITQAPSPVASGSEGHSPLSFAECYNENPGLTPVSSTTTTPPTQLLLTPTDTNAPIHLFPPLGQSSLSFSVTNTPNSTVSTTSSRTKRKASEIEESPRPKELVDTTVLSDDDEKEVRRKRNTAAARRYRQKKQDRMTELEEELAEERKQKDMWRQEAQRYKMEAEKWKAMAEFMQQQQAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGQ9</accession>
    <name>U4LGQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGQ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="178" mass="19393" checksum="80A510F7E2CABDBF" modified="2013-12-11" version="1">MQTVQCVKRTPITWRPSSPDTLTRHFISDNSALRRRLMVFAMALFTASIDSDSLYRSSVPPESPTSHTRLEIPDSPIVPVLSAPIGSLHPSPCAQTFFRRPSRHRVTERRDHFPWGPELLSGAFGVLVHMPAATSASTKGNPRNVIIRTLAIFSPVISAPAGHLKASAGCACARRGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH73</accession>
    <name>U4LH73_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to WD repeat-containing protein YBL104C acc. no. P38164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_10966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH73"/>
    <dbReference type="STRING" id="1076935.U4LH73"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YWIASYL"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="5">
        <location>
            <begin position="488"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="4">
        <location>
            <begin position="887"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX11372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="970" mass="107968" checksum="3B48963C91E506F6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHG4</accession>
    <name>U4LHG4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHG4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="1947" checksum="C0D996CB68614FF9" modified="2013-12-11" version="1">MLSSFVCLGTIPFSSVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHK0</accession>
    <name>U4LHK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ankyrin repeat-containing protein [Grosmannia clavigera kw1407] acc. no. EFX01243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHK0"/>
    <dbReference type="OrthoDB" id="5497808at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19133" checksum="0B4B7E953A6DED64" modified="2013-12-11" version="1">MDSGRPNHLSSNHDSPALDPRVMDSSTSTPLPSRCRTFRLSDIPINMNAAMPCDYLVALKVGNRCIEENSQVFSLAMYGSWQVASVSFRLEPDIFKGCKPDQNIYLRVPKRRIEGHAVSFNVAVDCDFYGMTAFYQPPGAMIKYDIFAVTGLSVHTFGSWKSPDQADVMWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHM4</accession>
    <name>U4LHM4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHM4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="24" mass="2948" checksum="B68D8EA9763BE950" modified="2013-12-11" version="1">MMYLAKYRASGQRRVQIHPIFMCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIF5</accession>
    <name>U4LIF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIF5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10281" checksum="864E12661B9F0A4F" modified="2013-12-11" version="1">MLDPELIADVITCHGIFRKSHGPTKSETDAVNSFSIMHVRIICLLQKAEKTLNYHQSIDSKLRVINVTLMGVRNDCAAAYLAISPSRRGRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LII1</accession>
    <name>U4LII1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Uncharacterized glycosyl hydrolase YIR007W acc. no. P40566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LII1"/>
    <dbReference type="STRING" id="1076935.U4LII1"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AACRYFA"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="4">
        <location>
            <begin position="165"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="723"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="839" mass="95492" checksum="E71786FC78250D66" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ02</accession>
    <name>U4LJ02_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ02"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="6453" checksum="2F87D690C65B674D" modified="2013-12-11" version="1">MRYQHNTSRTHGLDGPTECQMGDRRTRRISEGYVYNEKTNGWFKNCFQLWVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJJ4</accession>
    <name>U4LJJ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein RBE_0317 acc. no. Q1RJR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJJ4"/>
    <dbReference type="STRING" id="1076935.U4LJJ4"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWEATEI"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="615" mass="69146" checksum="A4A823C2A333DF17" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMC8</accession>
    <name>U4LMC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMC8"/>
    <dbReference type="OrthoDB" id="5429030at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651576" evidence="2">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="48092" checksum="440CF73D41D654FC" modified="2013-12-11" version="1">MITMAGRSLLLLFAGMLAVNAAPMNSNHSPIQTVYATVTKTIAMAVTHTLPCVLETPICRHTDEHDECHPDPPHCERTEDGCQHDHHTDEAIHLDARHNDETCGAYTGPACPDGNMPTCECRWWGWDCNCAPGAGEMHMTKTTVMCTETMTLTNTYFVDNEMCPPTSMPTGDPEPEPTNEPEHTHMPQPTQGPSPGGDMCPPGTSYEVITFDDVFDGAGSQIKEAVHKPKSPFEYRGFTFDPDWAFALCENMNEETDDRAMSCNPSTTEGKYFVSLYYQLAKHFVSRVSRRITYDLYNPTSSWEVLSYSLTAFPKPGQTITILLCAWSVEDQDTDIEPTFCHAEYFAEADNNVRREVRINNKEQKLAFIEFTSYDNYYAVGTRGRLTEISRVAPRDEKTKDKSKDKGLRAVEFLLEDMAVCIPPIEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMW1</accession>
    <name>U4LMW1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936097">
        <property type="protein sequence ID" value="CCX33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMW1"/>
    <dbReference type="STRING" id="1076935.U4LMW1"/>
    <dbReference type="eggNOG" id="ENOG502R4J4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="8"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="405" mass="45298" checksum="444D1BB27AF53DE5" modified="2013-12-11" version="1">MTMISVGLVFLIYRIIGVVKDNEVITDTAFDVLSLEALLLVPRIFSLLSLIPFFGVLIPCLKQMSKEFLKFLVLIVILYFGFLTTFSLLARDRMSFANVFWMLVSVFFGSSSVGFQAMREISPILGPPLMLIFVTITNILLITSLISLLSNSLTTMLSNAREEYLFMFSIMVLEASSSSRLVVYYPPLNLLPLILLRPFRLFLSSSRIRKWRIMLLKLSHCGLAYSIVVFERLQGKERRHTAWGPNDNDKKGGPASLGNSGLGISLFNRSSVWHPRRLQLAGSRLGLGVGGGLHATTTAPATSAASSVRLDDRLEGPSEGGPSPGPTQRNYYDRGLLSQRDMLSPMSYNRFGGEENASSSTEELRRLRSEIEELNRKMDAILAMQMKPVESQRTEQQQPKRLDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNE0</accession>
    <name>U4LNE0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNE0"/>
    <dbReference type="OrthoDB" id="10329845at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="394" mass="46007" checksum="8E9113E4835795FC" modified="2013-12-11" version="1">MSDPPAASQPASAIPGRLTEGFSLLEVDLDRTVSGRSYPEYPPPSYPTVSYSAPVSHPEEGATGNTSPRPELPRNVQPEARPPLTAREELAGLVTHDSDSEFQDPFADPASLHLFYITDRELQLQVNHELRYDSKFKQALHGSNPKRKMSYLKKRHNRFFDLFRSIMKDAGRPEARDHLEGPHEMWKYTYRCPEEKDHPSRPFLHHWFHRDWKILEDHYTEEANLSNVWDEGAPTVYCDGERLVIRNPDKRRSSKVYDLMKVDSHGNRKDALQALKFLLVISQNEMLYNHREMIRDPFLMSEFYKTPRNTRLDPRPPHRPVVIKPKSKMNEWWTHTPWEDKLRTVFGHPSCVNKHRNHDWGYRFGGKCGLWKVEQVEDEEDEGAGRVADHLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPH6</accession>
    <name>U4LPH6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_02549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPH6"/>
    <dbReference type="STRING" id="1076935.U4LPH6"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="609"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="726" mass="81542" checksum="148A392D5E4AC821" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPQ4</accession>
    <name>U4LPQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Multidrug resistance protein CDR2 acc. no. P78595</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_01438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LPQ4"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQYFTVE"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1239"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="124"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="829"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1468" mass="162772" checksum="1DE5AB0E7940C61F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPV5</accession>
    <name>U4LPV5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPV5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="4228" checksum="37F66274334FEB3E" modified="2013-12-11" version="1">MTRTRRLITARPQRSSRVLYSLKIFASRAQNCHVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ51</accession>
    <name>U4LQ51_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936481">
        <property type="protein sequence ID" value="CCX34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ51"/>
    <dbReference type="OrthoDB" id="5469189at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="12615" checksum="0C5901920FF15AFF" modified="2013-12-11" version="1">MDREGLLLKQQAELTEHCCYTWEFSYLEERHMKLEIENRISSKWCYELLKDIKVDMKQLLTEAEELRKKFVPVKEFDAEKGAGFGATKMMDRQTLTGWTVRRFMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ85</accession>
    <name>U4LQ85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936171">
        <property type="protein sequence ID" value="CCX33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ85"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="9134" checksum="EF55CD123AE1250B" modified="2013-12-11" version="1">MYAYNKHLGHYIFISLRLPTLQAEVCLSRQLYNPGMHEAGKVEFYPSQSFSLISKLVSELSSESSTSYNLRRDLRQFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR03</accession>
    <name>U4LR03_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ADP-ribose pyrophosphatase acc. no. Q01976</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="23389" checksum="F373A857B70A10BC" modified="2013-12-11" version="1">MSLANCKVTETNPLSGEDAKWVKLVKTVYTDPNGTTRDWESAERCTRPVGVDYDGVGIVAVMEHPGQPPALLLQKQFRPPIGKVCIEVPAGLVDANETAEECALRELYEETGYRGEIAETEKSCLMFNDPGMCNTNLHMIHVKIDLTKEENKNPKPQLEENEFIECFTVPLKDLYAECKRFDKEGYAIDARVGTLAEGFELVKKWNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR15</accession>
    <name>U4LR15_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Rho guanine nucleotide exchange factor gef2 acc. no. Q09733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07067</name>
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    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29741.1"/>
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    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bud3_C"/>
    </dbReference>
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        <property type="entry name" value="Bud3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
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        <property type="entry name" value="Dynamin-Rho_GEF"/>
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        <property type="entry name" value="GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12015">
        <property type="entry name" value="Bud3_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="224"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1204"/>
        </location>
    </feature>
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        <location>
            <begin position="1230"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
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        <location>
            <begin position="1232"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1563"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1573" mass="174505" checksum="FA06DBF13499D5E7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR62</accession>
    <name>U4LR62_PYROM</name>
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        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_03704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR62"/>
    <dbReference type="STRING" id="1076935.U4LR62"/>
    <dbReference type="eggNOG" id="KOG2527">
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    </dbReference>
    <dbReference type="OMA" id="NMYTDYE"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX_dom"/>
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        <property type="entry name" value="PX_dom_sf"/>
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    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="16885" checksum="DF237DF3D5D43261" modified="2013-12-11" version="1">MQAPIQSTRPQSCEERYAPPENLLEVEVKNPQTHGFGSKMYTDYEVVCRTNIPAFKLKHSIVRRRYSDFEHFRDILERESSRVTIPPLPGKVLMNRFSDQVIEERQKGLQRFLQIVVGHPLLQTGSKVLASFVQDPNWDRTSWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRB3</accession>
    <name>U4LRB3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Fucose-specific lectin acc. no. P18891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRB3"/>
    <dbReference type="STRING" id="1076935.U4LRB3"/>
    <dbReference type="eggNOG" id="ENOG502SNJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAITERC"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="307" mass="33121" checksum="E2BA6242CECF6F97" modified="2013-12-11" version="1">MAPILNGSPLAALSFADGNGAHIRVYYQATDGSIKETFYDDKKGWALRSTDVIGKAKLNSGIAGCAWANGTQIRVYFIDTNNKICERIYEGGAAGSWHDGTLSVSHNFKAAPYSQLSCIGYDQNETLRVYYQDTSNKLRELVFDGSRWKDGDNSLPTATPGSSISANAHKGRAVRWIYYQDTAMNPKEIQFIGGSWKNGGYAPTGVFAPGAGISAAVYGQGDNSDLRVLSVSDDNRLRVTTFTNKGWAGTKNLTNTITASKVAAIVVAGTKTWTRAYYQAEGGKVAEFGSNDGQNWSLMQTSIPTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRE2</accession>
    <name>U4LRE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRE2"/>
    <dbReference type="OrthoDB" id="10427476at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="209" mass="24290" checksum="5140E513A2F9B6E6" modified="2013-12-11" version="1">MQLPLSLGYSAHPLKHATYRLAFCSTAQHSIQSISGFTTTTFSTLYQNTNYNMCRVDPEIYWRYVTAENEYNPTFEQVHKTNHYVYLRNHRPYGPLISFKGCCPICRPKDHRRKPLLWRTQDPSIGSLSWKSKGRGGPKDEIEQPEEDMRGISKEFGGVGVEEERGGMKWIRLGISAIMLAFLMLLFLCLEQKRNNAFYEECMNKRGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS51</accession>
    <name>U4LS51_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS51"/>
    <dbReference type="STRING" id="1076935.U4LS51"/>
    <dbReference type="eggNOG" id="ENOG502S1T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEHIDAH"/>
    <dbReference type="OrthoDB" id="5421842at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1038" mass="118698" checksum="13ABD8808E216537" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS79</accession>
    <name>U4LS79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative xanthine/uracil permease C887.17 acc. no. O94300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS79"/>
    <dbReference type="STRING" id="1076935.U4LS79"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYCTDAF"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="632" mass="68362" checksum="D9047B806DB1DF6B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSE4</accession>
    <name>U4LSE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSE4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651870" evidence="2">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="182" mass="20297" checksum="AE03F0F8019DB0E2" modified="2013-12-11" version="1">MESAHPTVGLVFLLSITYSTITNTMGLHMNGVNETAAIENYKQCMLQLNYTSWGRGDPDVGGIGVFSSLCILCISCVVGFIVVVPLGFYFDLDRSNGIGKQHLKSKRIIDQILRRLNIAFTISLDSILDTAITLSIIVQVGIMVWERVKTQMSRESELGGHLYNWIMLDYVNLITFFPRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTI9</accession>
    <name>U4LTI9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_13721</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTI9"/>
    <dbReference type="STRING" id="1076935.U4LTI9"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX32870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="422" mass="46594" checksum="7B15E495DEF88AAE" modified="2013-12-11" version="1">MTSTDTTEITPDVPAASRQPRKRFVGKKTADTLRSANGTPASIEDTGSALAAAPSAKRPLRTVTTIPEDILNDPDLNAAINTLLPKNYNFEMHKTVHAIRRHGSKRTFCTGVETVIMGDVTYGACCIDDFTARALECDLLVHYAHSCLIPVDVTAIKTLYVFVTIGIDADHLLATMERNFVAGKTLALVGTIQFNAAIQRLKPKLEAAGYGVLIPQVMPLSKGEILGCTSPIIDTSKVDALVYVGDGRFHLESAMIQNPQLAAYRYDPYSRKFTRESYNHNELHTLRREAIGQAKKAKKFGLILGTLGRQGNPNTLDNLEKRLKELGIDYVLLLLSEIFPGKLKMFEDVECWVQVACPRLSIDWGYAFPRPLLSPYEATIALGMREEEWDEVKGYRMDFYAKEGLGRTKKEGGLPGLAEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTX9</accession>
    <name>U4LTX9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX33205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="172" mass="19687" checksum="A992C8168B83537A" modified="2013-12-11" version="1">MSFEVDGYLVVRSAIEMEMIQNVETDISREINVMEGMRSEQSFDEGAAFKLGWPQSCADIVSTFVKKTLPNLALKNRFLHLKSSELCLLFDRQKTVAVSPYGHTDIFVVIPIRNPASELYPKLYESDENQCKEVRLELGDIMIRDGRMGLLYPAMERQLLTLFVCLHYSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU17</accession>
    <name>U4LU17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU17"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5148" checksum="5F2E31F3DD648B3F" modified="2013-12-11" version="1">MSALPQPSAQMLYRMQKLLSRNCRSGILSYSSASSKPKPFLRCSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUY9</accession>
    <name>U4LUY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUY9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="33" mass="4165" checksum="C46910497117E746" modified="2013-12-11" version="1">MYHEAWCMREVTDSGRMRWPMRYSKLRNIALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVG9</accession>
    <name>U4LVG9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVG9"/>
    <dbReference type="STRING" id="1076935.U4LVG9"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="97"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="43843" checksum="6A3D1AFB42AAB9C7" modified="2013-12-11" version="1">MTSHQHQLVPRGIFKNIISVEKPPHYNNWIAFDIICVSIIVIVLTLRFVEQRKIEAAAKAGITNTIGNVSITLATVIIVIWTGFSTKQRIQYRKWKGGAKDAPNWTSEAHMLYFFAGFMYIMTLWLIKAAFLSMYFRIVPFHISLNIRRVIYIITFYVGFTFVLNFCIHLFWCHPVSANWAADNPTSTPIPGTQRHCTALLDIVPIAILFFTNITTDLGLLSIPLLILRSFTLRGSREKYAFIFVYLIGLLSLLSAMFRFFSIIAGFKIATDKGWGTFDEQVVKQSRIYTEKALISQNVDNLLKNWATIEYCSAILAFCLPSLRNLLKVKRDCEEEAQVRGLAEYESEQVLEEGVQHGLYGKIGSAEQLEPFQGEEEEKEGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVH9</accession>
    <name>U4LVH9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to 6-phosphofructo-2-kinase 1 acc. no. P40433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVH9"/>
    <dbReference type="STRING" id="1076935.U4LVH9"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HAYRYNE"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="247"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="682" mass="75664" checksum="1C9988C57747FB4F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVP3</accession>
    <name>U4LVP3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_04246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="HF936618">
        <property type="protein sequence ID" value="CCX34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVP3"/>
    <dbReference type="STRING" id="1076935.U4LVP3"/>
    <dbReference type="eggNOG" id="ENOG502QQD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSYVGCI"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="70"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="301" mass="32459" checksum="023941AF067C43C5" modified="2013-12-11" version="1">MNPSAPDADPTTLIKTHYTSHIRSQSASSDPHNKAVASAFGYTPHDLASIPSTSNLGVSCGNPLARAGLKEGETLLDLGCGGGLDCFLASPRVGKTGRVVGVDMTASMLELAERNRKLGGYGNVEFLNANITSLPLPSGTADIITSNCTINLVPHAQKPVVFQETFRLLRPGGRLAVSDILAKRDFPEELRNDVGLYVGCVVGASEVREYEKWLREAGYEDIFIIDTEKDLNVYKEVGILDMTDGNTDEGDTRLPEETQTGCCGVTKSTEDRRQTSSDRLADVDLNEYVGAYQIFAIKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVX7</accession>
    <name>U4LVX7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized RING finger protein C2F3.16 acc. no. O14099</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVX7"/>
    <dbReference type="STRING" id="1076935.U4LVX7"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CARTIIN"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="338"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="661" mass="71823" checksum="B5F2A7DD7F950D3C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVZ8</accession>
    <name>U4LVZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVZ8"/>
    <dbReference type="STRING" id="1076935.U4LVZ8"/>
    <dbReference type="eggNOG" id="ENOG502SB2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="476" mass="51828" checksum="400CF87436872240" modified="2013-12-11" version="1">MRPTISTTSHLDVEKALPISPDEISRYNQFDFGFPATPTPLSPIHISPIMASNHTDYIESKDAPPPYTPYPRATESILPSPIGPAPAFPPQAARSYTRFIPATWRAVRAEDLPTSGLSKSERRRRQFERNAMLREKYGCFAPVMSRKWICYLLLILIAVIIIIAGAIVGSKKQEGDIVAEPDTLGKVTGASPALPIGTVVVQPFRQAQVLTACTASPKTWSCTPPPGASLTTIAAENDGAKVPEFKFVIKDMRAAQGQPTSAWTPFPDAALVKDYQNSAVVDKITVDPKEGEETDFLISLAGMTKDAASGNGGTVQDDAAVIPAVMRNQPLRLFNRGQDTEHWGFQVYFDKTAYFTGENSTIKEAKKEDATNMVAWKGTRFSVKIYTKTLGKQISGAGVTDAKANKAKGDVSEILNLRVEIWEDGIAGSETTKAMMVYEVGKDGQIKGGQQFKEPSRGSLAAERGCWCRWSNFGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWC8</accession>
    <name>U4LWC8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_01442</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWC8"/>
    <dbReference type="STRING" id="1076935.U4LWC8"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IIGCRGC"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="14">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX33571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="19246" checksum="269CB524BE33512E" modified="2013-12-11" version="1">MQATTDYYTLLHLPHPPSPLSPQFLKKAYHSALLRYHPDKTASQASHSSNTSHDLSTSTSPTDAPSIDTISLAYRTLSDPGLKKEYDAARAAELQGGKTGNGSEVIGVVDLDDFVCHDGEDEVRWTKACRCGEEEGFVLTEKELGEAAGEGEKEVLVGCVGCSLWWRVGFEVVDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX18</accession>
    <name>U4LX18_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Pre-mRNA-splicing factor CWC21 acc. no. Q4IB70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936389">
        <property type="protein sequence ID" value="CCX34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX18"/>
    <dbReference type="STRING" id="1076935.U4LX18"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRSHYDG"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="9">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="329" mass="38716" checksum="4447AC0A274EEDD5" modified="2013-12-11" version="1">MSSNVGLSTPRGSGTSGYVQRNASFLRPRDPIEQPKETRYKQRAPDAEILLHDRKREVEVECLKLQDKLEEEEVDEEEITKQVQELREKLLANLNTNSRANARDLKPHQVHDIAAAKMVESERLRSALGISADYEEGSHWRRQEEEKQRREEAIARGEDPRPQNRRPGPPRENWGQGPRNRNNQERGRLSREAGDNWRDRRERDNAQQRPKWGGREERGDRWRNEQRGGDRGGDRGGDRRRDDRDDRRRDDRGGDRRRDDRDDRGPRDDREDRGGRESRDDRDARDSRDVKEAREPREAREPRERSRSRSRSASPRRSASPRRSPSPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXB4</accession>
    <name>U4LXB4_PYROM</name>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17868" checksum="4C4240C7F24BAF70" modified="2013-12-11" version="1">MTQEFKDNIVAEITSKSQEMFLLRALQNDAVLEKTTVKRRRDALKAMPKALNDAFELTVERIKSQGLDSAEQAMNILKWIFLAERPLTVDELGHALAVEPEDKDMELENIVDAKAVFEGCLGLIVLDGATSTLRLVHKSLQDYLQVQYDARLIFHDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4449" checksum="C54258E87D6625E0" modified="2013-12-11" version="1">MRALNSVDNWLRMRLATWFILGHEEIQHPDPEMLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUY1</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
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        </location>
    </feature>
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            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="461" mass="52932" checksum="C5E667608BEF5A0D" modified="2013-12-11" version="1">MSYETPRRPTGETPPRPTGDNYFADEDNSRYYDRSPMGSPPRTPVRDPENEHWPSPTSPENVSHFPPDDPYRVWYEAWVAEKSGRESRVDKEAAAGGERAEGSMRSALQEGSCRTMPLGEGEAIYEKDMEDANAWFDRIIEEEDKKNVYGVESPAPSRSHRASKVGNQSGMLDDPITLSSSPRDDGNVPVPQAAIGSGNAEQERPRPKYGPFLPQSPRKRGRDEFEGRKDKQREGETRYTTEDEHRNYHIQDNLNLDYEPHNEEQGEQDEQDERVSRRRMDRWNNGAAETEEEEARYAADDYYVNRAQEAAGYDLPDHESDDNRDIPEPAPAPTTPGPIGPMQIIADRLGVEIRALFDEPPYEEALSEMDPEEEKERVNGRRELHHLESYLPGFPDDREVFDQTDMLVMWRQALAEAAQIEAGTLAHAAAHLSYRHKVWVADQWQVDIRKQLRCIKRRRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUY6</accession>
    <name>U4KUY6_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_03072</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5440994at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="33596" checksum="1C4B82079BA714D0" modified="2013-12-11" version="1">MDRGYLVVALSSNTGSDYSISSGEDYDRNYQTISKLHAFTTQLVNKKRAGESLIDDQIIKDVEEKLLHELVVTADEAVEARLREKLLHRARTSMSRKQQKREADIDEKAQELLDAITADDEDDDGETAIERMLHNFNVRQPTRNASQPTEIDWRGECVSNILRDAQQKLREKLRDQKEDLITKFEAETQEKIDNINAERAHADAEKEAVIRDLTEQLDAKSQALKISCTKIEQEMGFRKTLEDALEVLHHTEQQRRKELVTVKAEFERQATQLRDVLEVHSRCPSVGNQVSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV39</accession>
    <name>U4KV39_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935247">
        <property type="protein sequence ID" value="CCX05338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV39"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="90" mass="10514" checksum="2C18835D5D0BB3D1" modified="2013-12-11" version="1">MVCYFVHRVRVELRSRYLPTPLVAHFVPSTRSTSPHSTSTRSPEDRNYYHSVFLLPSVLPVEVKSYLLRREITRKANKARFVLLVRQGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVS7</accession>
    <name>U4KVS7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVS7"/>
    <dbReference type="OrthoDB" id="10640360at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="608" mass="69730" checksum="1076C1B02215C89B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVT4</accession>
    <name>U4KVT4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Probable LRR receptor-like serine/threonine-protein kinase At1g07650 acc. no. C0LGE0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVT4"/>
    <dbReference type="STRING" id="1076935.U4KVT4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="180"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="598" mass="67562" checksum="DF11E1D8F77909D5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW36</accession>
    <name>U4KW36_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW36"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="6306" checksum="F0D40326BB62A21A" modified="2013-12-11" version="1">MSQPSSSSGQPRASTDSSAPLLKPQQSAAEKKAAEKAAKKAEAAKLGVKPGHPVVGGGFQMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW77</accession>
    <name>U4KW77_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW77"/>
    <dbReference type="OrthoDB" id="5428693at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25729" checksum="6EA2993EDE1ADA2B" modified="2013-12-11" version="1">MRTLKDIPPLDPEITNLPEHLEIINPKPKRTWWQFPNDDDEGRHVKKRRHSTTREEKLEALSFLKNARTWQINKAGYAELKPLSVRYAAEILGFHESQPRDWKSHEQKIRDAPKNSKKCGVGAPPAWPEMEVRLAAECGEKYRAGYEVNRDWFYRHAKKIYEEEYPNEVEVKDGVKSYLCEFSNGWFQGFKKRHGLSCRDPKGIPAEADEFTVQSSDEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXK0</accession>
    <name>U4KXK0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935320">
        <property type="protein sequence ID" value="CCX06887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXK0"/>
    <dbReference type="STRING" id="1076935.U4KXK0"/>
    <dbReference type="eggNOG" id="ENOG502SBDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAKSICQ"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012881343" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX06887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="375" mass="40723" checksum="6E8D39D093368584" modified="2013-12-11" version="1">MKSLLAFAFLALATAAPTGSQSEPQFKNAIGKNPGVIGLGGGIEGTSVDKTGKLYTVNSVGLYALDKENSTLWTNGTGGMSVVGLSSSRFTRTLGTLIGDPSGHKVLNVQDPKKPTLFLDASQMLQPNDMTISLDEKKIYFSGMNWTANVGEVWYYNVESKKLEKVPWTGDRANGIELSHDDAHLYVTSARHNTTTFQTLFSSVIRYDINKANGMPENPQTVLDYRKLRNDAGYFPKDAGTNMYANLSTDATAYGAAVKDRKNPQDNEMDFDPDGMRMDSKGTLFATLNAWKTVVMWDTTKASTTAKFMELETVYWPTNLELGGPEGKTVTVVGKCKGNANTCVDSFEHSTPGRAFKNLQGDGGNTGKDTTDDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYQ3</accession>
    <name>U4KYQ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935314">
        <property type="protein sequence ID" value="CCX06790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYQ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="109" mass="12586" checksum="731EBC4E6F7F679C" modified="2013-12-11" version="1">MYTWCQDKLDSATGNTEYRGIQRAEYNRLVKERFARLERDKPKKNAIKATPDASTSFGLPYVDLSDEEYAKVLQAAEKDFVKRAWKRAGKKADEAQREEKKAKRVVGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ18</accession>
    <name>U4KZ18_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Phosphatidylinositol 4-phosphate 5-kinase its3 acc. no. O13853</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ18"/>
    <dbReference type="STRING" id="1076935.U4KZ18"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="506" mass="57445" checksum="5E1BD74C911932B0" modified="2013-12-11" version="1">MNYLYIATLYLTFSSTANVNASVLNNRGVLSSAIEAESPQQSSSEWDQQLTNATHSEYLQQKRGVSEPKIVKRDGSKSERALFRMLTGIASTVWRVAPVVYRDFHQLDYNEQYRVSFNKNGTALGPHSKYDFEFKDYAPDVFEFIRSNFEVDEDSYVESLTGNMRMDELASPGKSGGTFYFSTDKKYVIKTIHEGEHKYLREILPEYLAYVKSNPNTLLSQFYGLHRIKKWKGGKKYFVVMNNVFPPQNEIHQTWDLKGSTARRYVDEDEIAAKPKKTQQDVNWINKQMRLHFGPKKAEELLNQLARDAEFLRKRHVIDYSLLIGIHRIGNESVAITPSKSIFHADNGCFRSTNANDEPDDLLYCLGVIDILTYYTAWRAVDSFFTSFGIPSHTLSTVQPKTYARRFLKFIGDQIQPKSSEESEQNASNAETNDSSVNSTEISTDITTSSSSYTKNASSELAESLSPMMPNNATTESATPSPDTTTMPEASHSTRKVRGAERPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZC9</accession>
    <name>U4KZC9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Cell wall protein PRY3 acc. no. P47033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZC9"/>
    <dbReference type="STRING" id="1076935.U4KZC9"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TSAVRMW"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650983" evidence="1">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="158" mass="18166" checksum="5A1D29A6B354C152" modified="2013-12-11" version="1">MKLLALSLSIILFIISVVFAEHEDHFPQKAIIYNQEVFKNDFLVLHNQLRREHDAADLVWDNHLQSSAQNWANNCVFKYSKGSYGENLATDYKDPSNSFGLWSEERQHYNFEDPRQSKAVTGHFTQVVWKGSQNLGCGAQLCERPMFPGQVDAVWCVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZI1</accession>
    <name>U4KZI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935380">
        <property type="protein sequence ID" value="CCX07890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZI1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2620" checksum="C288A7E1C7F26B20" modified="2013-12-11" version="1">MRGSRATTTCSPTGKSLYNRWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZX6</accession>
    <name>U4KZX6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZX6"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121594" checksum="1BD782A5FC62AF06" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZY5</accession>
    <name>U4KZY5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZY5"/>
    <dbReference type="STRING" id="1076935.U4KZY5"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KLITHQY"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="553" mass="61664" checksum="61DF2612C1F9BD8B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L071</accession>
    <name>U4L071_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative mitochondrial ATP-dependent helicase irc3 acc. no. Q1MTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L071"/>
    <dbReference type="STRING" id="1076935.U4L071"/>
    <dbReference type="eggNOG" id="ENOG502QT4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HVIDMVA"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="240"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="465"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="865" mass="96239" checksum="3CA17D646022A0C1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0K2</accession>
    <name>U4L0K2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_08348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="HF935429">
        <property type="protein sequence ID" value="CCX08755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0K2"/>
    <dbReference type="STRING" id="1076935.U4L0K2"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYQGQEQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="391"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX08755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="837" mass="93398" checksum="013C281877F2C7EB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2G3</accession>
    <name>U4L2G3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2G3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15573" checksum="1B18BD60CAFAE044" modified="2013-12-11" version="1">MLSAEDIILTFVGFNGHLDSFVLGIFLTVIPMFMTIFGQDPKASLYYYGTRVFFVLVYLGLLYLSSQEPAVGWTQAFIALCGISCLFWFFAKMHINSEASIKMNIESLETRIVSLKRASKDLDDEMRRCKAFLEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2K4</accession>
    <name>U4L2K4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935469">
        <property type="protein sequence ID" value="CCX09524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2K4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6593" checksum="2162845AAAEA2B7F" modified="2013-12-11" version="1">MNGAMNRERIEIDIISMFFILTDRGRPSVPLNHVTDLAEFRRRRLTCIWMPENQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2L6</accession>
    <name>U4L2L6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to 7alpha-cephem-methoxylase P8 chain related protein, putative [Coccidioides posadasii C735 delta SOWgp] acc. no. XP_003068733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935474">
        <property type="protein sequence ID" value="CCX09539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2L6"/>
    <dbReference type="STRING" id="1076935.U4L2L6"/>
    <dbReference type="eggNOG" id="ENOG502RXYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPIEHRY"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32765" checksum="687EBB2BA2F618F7" modified="2013-12-11" version="1">MSATTTTTQTEEFVPRGDVTSSLSFYAPPADGSRPAYYIPTDAAPYTNFGETLSQVLIRDLRGNESTLSLDKQAYNLHVSPTSFQFSDYEDEEKIKSVYYPEVEQIIKTHVPGAKNAKVIIFDHTIRRSAPDASRGPVLRAHIDQTPRSAALRLRRHLSEEEAQAVEANDERYMILNVWRPINGQVVSHPLAFADSSTVEEEDLVPVAHVYPDYEGETAGVKFSEKQGWWYVSGQKEDEVTLIKCFDSRRGENGEYRRVPHTAFIHPDTKEGARGRESIEVRCLVVGVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2T8</accession>
    <name>U4L2T8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Uncharacterized AAA domain-containing protein C31G5.19 acc. no. O14114</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_09268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935486">
        <property type="protein sequence ID" value="CCX09675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L2T8"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PDLENWF"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="703"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1165"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1377"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1679"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1404"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1444"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX09675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1730" mass="192084" checksum="94B8D0343D79CC4A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3F3</accession>
    <name>U4L3F3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3F3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="14036" checksum="642F53CB91F278A0" modified="2013-12-11" version="1">MRQMCTKTCEFHPASLIQVNNRQKDNASFVFNLRRAALIIPPASRLSLNYIHVQSRLRHDDTRTRYDTRLKGNHSNQPIVTVNTLTTTLRFTGFASFTSFVSLHHLHQFLQFQQLRFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3S5</accession>
    <name>U4L3S5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935555">
        <property type="protein sequence ID" value="CCX10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3S5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="4863" checksum="04735FB71B3AD26E" modified="2013-12-11" version="1">MVVVRVYDKVSAVCTVSDTSWLNIGVYIIVNQLQLRLLLRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Z7</accession>
    <name>U4L3Z7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Probable cytochrome P450 313a1 acc. no. Q9VFJ0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Z7"/>
    <dbReference type="STRING" id="1076935.U4L3Z7"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICNARQS"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="558" mass="62095" checksum="700E6A6DE7A8AD3D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Q8</accession>
    <name>U4L4Q8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Replication factor A protein 3 acc. no. Q92374</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Q8"/>
    <dbReference type="STRING" id="1076935.U4L4Q8"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRYKEIF"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="110" mass="11928" checksum="187E01F1C625C38A" modified="2013-12-11" version="1">MSSLNISPQTPRINAAYLEKWVNHTVRIVGKVTGVQGGMANIDSAGPVTLQLTRDCALIPNNGAEVIGKVMPDGTLKVLTSWDLGPDVDYSIAEAIVDVNHRYKQVFYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L591</accession>
    <name>U4L591_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L591"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7341" checksum="46C7905EAB1F35D5" modified="2013-12-11" version="1">MIRGERRSLALRTEFPHPKHLESIFNDCGYTILTTELISLCCSMTKFRLRVAVRLATDWGRGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L653</accession>
    <name>U4L653_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935654">
        <property type="protein sequence ID" value="CCX11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L653"/>
    <dbReference type="OrthoDB" id="10449779at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="250" mass="27788" checksum="ABC755B7EB40F6A7" modified="2013-12-11" version="1">MYPQTLPNMFSSSQSSLIFIDSFPETPIKIDLPIRTPTTGSTCSDYQDISVFLSPSPEIIPAASSGRLLGFKSNSSLSLLPAFSSRSASSTHSGSVPSSLWCGGGSFVQLPRSNLNIVNKTESPPDYSPATLRIFVPQPLDASELTRRLEYLAAERHEELKEMVNRIIGGVNKDSNNEMLAMITKLKSGEEEWTKEEWNERMDEFFREKEEIVMAVLDAADEWVADGLERVNDKPTARELTGRLWGAMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L694</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935259">
        <property type="protein sequence ID" value="CCX05545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L694"/>
    <dbReference type="STRING" id="1076935.U4L694"/>
    <dbReference type="eggNOG" id="ENOG502SEDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEGKPQT"/>
    <dbReference type="OrthoDB" id="5380429at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651944" evidence="2">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="277" mass="29712" checksum="5530D9CE7A623AD0" modified="2013-12-11" version="1">MKSSTLAVLLAATATTFGMAIERRNDDGTWAPGKWEGAGTGFDDGKWHPSKRADDGSWAPGKWEGGNTGVDDGQWHPSTKRSDDGSWAPGKFEGAGTGFDDGKWHPSKRADDGSWAPGKWEGGNTGVDDGQWHPSTKRSDDGSWAPGKFEGAGTGFDDGKWHPSKRADDGSWAPGKWEGGNTGVDDGQWHPSKRADDGSWAPGKWEGGNTGVDDGQWHPSKRSDDGSWAPGKWEGGNTGVDDGQWHPSKRNDDGSWHEGKWEGAGTGFDDGKWHPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6B8</accession>
    <name>U4L6B8_PYROM</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6B8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="12513" checksum="5A4E964E8AEF284C" modified="2013-12-11" version="1">MGKFFRYSFTEFQRRRKLRLKLEEDKREVDRFNACMQEAKRMSAITADPRGIDKIYTKNIAPIMMERIKIMKQYSAVAKAAQYLIRSATLDKAVDDQMTRVYRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6D7</accession>
    <name>U4L6D7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6D7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="283" mass="32603" checksum="8858D5B705DD7C00" modified="2013-12-11" version="1">MLPPDDDLSCATAIAIARAFAPTRNQALAPINNQASAPINHQDIKLQNICDLIDYSLMDLSVDVDIEPPPKAVHPAKRMRSVFQGKEKTELLLKKVLKKKGDKPVGYGQLASEFLKRLEITPEPRRGSQVDSENPALNGLKYAWPEETFDCDEMAWELFSQLKTVIRPEEERYSMDVVPTIKGSVNYGRMNQELLWFLLAAISQLWNRDGNKDFDWYPKIHIELDKVEREHTQRDPDDKDFNACALNEMYDTFRPEMYNDHEMTRIFRDGATQVQGDRLTFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6N0</accession>
    <name>U4L6N0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935679">
        <property type="protein sequence ID" value="CCX12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6N0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="111" mass="12670" checksum="C9B68B649F48FECB" modified="2013-12-11" version="1">MKEGSNWFPRGWMSRGSDAAIGKKLRDELNDKKVAAAVQSTIAMQKNVKNRKYAPAPKKGKPAKAPKDSKCYERGEGYLYLQYITRRVIRSGVILKDYFRTMTCCSEEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6R6</accession>
    <name>U4L6R6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6R6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="3200" checksum="B54B172A06B1B29F" modified="2013-12-11" version="1">MRNGDMQGNHVLRTCVRVQFTIHYPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6V8</accession>
    <name>U4L6V8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Splicing factor 3B subunit 1 acc. no. O75533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_05357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6V8"/>
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</entry>
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                <person name="Kumar A."/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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    <accession>U4L8Y5</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <begin position="1"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="332" mass="38280" checksum="F286B1BE2CDE4307" modified="2013-12-11" version="1">MGLPYLKDKETVRGRSGTDSSVPTVYSEDSQQTLWDPKVNGPLNNITNGQENTKKVSYGEYIQLPERAVLYDNILPAKPKADSGEYMRAAHPEFYYGPSKAPQNSASYYTNYDLDHSKDPFQHGSAYWARKRLEDLTKAKLETPKHNVQNPPPNLVEHICLVDPKDCQFHRDPEPGWSVQETRNWEMATGRTAPPLKFNPYTNSNGRFHEYVVRAKDQGRQCWYKATQIWYVSTEKLKKSAESTLQDLKKLPKRVAHLPGSLREEFLEWRKERNLGRKERTYQRHAAFYTVEKIVMAPIIPIKEMYTKLRKKAMKETTSKHGNSNGPSNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9G8</accession>
    <name>U4L9G8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935316">
        <property type="protein sequence ID" value="CCX06829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9G8"/>
    <dbReference type="eggNOG" id="ENOG502S6E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSCHITC"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652047" evidence="2">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="316" mass="37139" checksum="999DD718AA1F7638" modified="2013-12-11" version="1">MTTISVTFFLLQALSYAFKVSAKDFDPPYGDNTALNQQPAPPWVDEPRKRGTLNILSGCIFTLSLCVYKAIHLNIPEPLESQWTFYRRKTKWIIIAILAPELVVYCAFDQFAQVRRLVKKSIDKRPLSMLQAFYVAMGGMVIEIRNSIYARKDETLRVTIQAYHWLNFPDQMLEKIPTDNRIRDKSKADILSKLLICFQVVWMTLRVISRKILHHPLTVLEVHTLVHVIYALLMYMLWFRKPTDIYHSTVVVAGDGTREIDTYFKKAAFKRWAERMKNFDTIVDRDMKLRVSNRYRVADLESLLYFYNLWSSSQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAB1</accession>
    <name>U4LAB1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAB1"/>
    <dbReference type="STRING" id="1076935.U4LAB1"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000228">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008865">
        <property type="entry name" value="PRK11898.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="215"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="33517" checksum="1CE3B8AFF0A9F452" modified="2013-12-11" version="1">MASPTLATPTPPPTLPSVGYLGPPSSYSHQAALECFDNNTHTFVSQTTIADIFVAVQSKTVTYGVVPFENSTNGSVVFTLDLFCDRNNTYPDVHICGETYLDVHHCLLSCEEEIKSLKRLYSHPQAFGQCEVWLNSTVKGVERIDVSSTSKAAEKAKNEPGAAAIASRIAADVHGLKVLARNIEDTSDNTTRFFVLSATERSEPTQLDGRSDKTLLSFITDHQPGALCDGLKVFKDFGLNLTSIVSRPSRKMPWNYIFFVEFEGHEKTENVTDALEALKPHCAEMRVLGSFIDKQKLRKPSAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAH9</accession>
    <name>U4LAH9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAH9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6828" checksum="06B6F392556225BA" modified="2013-12-11" version="1">MRSFRVGARFLRPSSQLLQNPRSHIHSAVEGVYVMLPCIVLSPHSPSKCVFHAHSFAETLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAQ5</accession>
    <name>U4LAQ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C13E7.08c acc. no. Q9P6R2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAQ5"/>
    <dbReference type="STRING" id="1076935.U4LAQ5"/>
    <dbReference type="eggNOG" id="KOG2428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSDRSMH"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="397" mass="43744" checksum="277F6627D6B75486" modified="2013-12-11" version="1">MSDSELSSAHGGSSPAAPASPSKPTGNRYDTMFGSDSEDAGAASDSEALGARPASPPAADDDEPLDDLFGDEEKLSDVASVREPSPEPAEPERFVEVSLPRHPGPAPGNDQHLYLMKVPTFLQMEQKLFNPEEFILPAADPSDSASAYTRATNSIRIRRDANGRLQSNARVIKWSDGSMSLQIASSTNFYDLPRKDLTTNPKTPGKYVAAQNSHTYLLDPHEAAGTLRVVGHATQSLNVVSAASSSASDHAIQRLHAELASAIPTAARATPLEISTLRDPEAERKEAERIAKEKERANKKLEAQRRRARERDPLEAQARRSYAKVTGTRSKRDSPPIMGRGRGREDEYDLEDEFIEEESDEEEEGGSEEEERRPRKGRESERDRKRRRVVEDESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC34</accession>
    <name>U4LC34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935661">
        <property type="protein sequence ID" value="CCX11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC34"/>
    <dbReference type="OrthoDB" id="5289915at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="9537" checksum="46C74AEE5D8904D2" modified="2013-12-11" version="1">MSNSSNNQLPTAIRGGTGVTPTPANSYTNPDSKFASNGLSGMFESKSEGKNDSWMNTKPRVGGTNTNGVVNSGDSILGKIAERVKDTLGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC65</accession>
    <name>U4LC65_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Transcription initiation factor IIE subunit alpha acc. no. Q9P3W1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC65"/>
    <dbReference type="STRING" id="1076935.U4LC65"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="406" mass="45515" checksum="31C5B67B74BECA47" modified="2013-12-11" version="1">MDIAKSLVKCVARAFYDTRHILVLDALMIHNALRDDELARLLGLVTKDVHKLCGKLREDRMITVHSRPEQKDGQQRPVNRTYYYIEFRSVIDGIKYRVYQLAALVRKSVNNGADTKGYVCPHCNKRFALLDAVSLEQDDEGLFLCDRCQNPLVDDEESAETKLGHEKIQRMNRQIEKIERFLKEVDGVVIPFNDFDTAIANSVPVPRDKNQLPTATFVPVTAKKGEAAKVQQSIEISITSSEEKTTEELRAEQEKKKLQAEKNALPVWHTQSTVQPGAVTNAGIKEAAERAARERDGVGLARRELEVEEKAKGEEGGQGDAIAQYYAALAAEKAREEAEEADSSNEEEEEDDEDVDFEDLDISAPRTGSEEDDEGPAKRVKVEEAPVPAAEVKEEDSDEEVDFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCN2</accession>
    <name>U4LCN2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Nitrogen assimilation transcription factor nit-4 acc. no. P28349</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935404">
        <property type="protein sequence ID" value="CCX08251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCN2"/>
    <dbReference type="STRING" id="1076935.U4LCN2"/>
    <dbReference type="eggNOG" id="ENOG502QW0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YIAHTAC"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="776" mass="87400" checksum="94545DC3F313E833" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD11</accession>
    <name>U4LD11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD11"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="243" mass="28853" checksum="51A50030002EF06A" modified="2013-12-11" version="1">MTFYNSLSKWLLKVESTFSSEDPEEATNFTLQDRFDSWDPNSSRMLGIVYMTYDFIAMKRFNFWLPEAKRSLAETYLEFLQKERELGIEPREDIEEDEVVETNKWRNMKKDAERYGMVFVRPTKSTDEKAMIKDAEKDRLVFLESQSSRSAQPDRLECQKSEEEIIKLVVERHSKSNNWDEMRKDLYLRKCRADGYILDIKTTRNNVEALNVKDIGDFAWLTEEYTQSQAEEEGDEWQVVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD96</accession>
    <name>U4LD96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein YEL023C acc. no. P39992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935358">
        <property type="protein sequence ID" value="CCX29818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD96"/>
    <dbReference type="STRING" id="1076935.U4LD96"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FENAWMQ"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="16"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="685" mass="77450" checksum="7FDAB312EEE93112" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE28</accession>
    <name>U4LE28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ras-related protein RSR1 acc. no. P13856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE28"/>
    <dbReference type="STRING" id="1076935.U4LE28"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3537870at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="259" mass="28362" checksum="07EB6BB27483DFB3" modified="2013-12-11" version="1">MASSSTSTETQVKQELQTKASPVQKIKLHKCHVLMLGAKGTGKSCLSSRFATSLYSPLTDPTIDDVPTSSITFDNTRFTCHYLDVKSQQWDLLEGYVSSSDAVMLIYSVTDRDSLEEVRKLGEAIRKLDDEPNGSTSTADGKRGGMRDGNGILVDPNGPNGPSIPNGRGSKLPIVVIGTMKELDEERVVEEEEGRGVARGLKCGFWEVSAATGENCERVQEALCRVYLARFEEERERRAAEDKGKDKGKGKQKRGCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEA1</accession>
    <name>U4LEA1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Uncharacterized membrane protein C17A5.08 acc. no. O13770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_08638</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEA1"/>
    <dbReference type="STRING" id="1076935.U4LEA1"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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</entry>
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    <sequence length="903" mass="97180" checksum="DE5653404A7DE4AB" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
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            <end position="26"/>
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            <end position="101"/>
        </location>
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        <location>
            <begin position="103"/>
            <end position="114"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="18779" checksum="7830334E975A1875" modified="2013-12-11" version="1">MAPSKGTPRVPKGTPKHPSNQLQVTTPKVIPSTPRRKPKPAAENESPDHLSSPFTPSIYTAPTPLKNAKVSPIPKTPVYKETATQTTTPRYSPGTINNPIVLSSPKTPKTPDTPSEWHFDSNSIEGEAPSELSDDYESDFYLRSTPCPGGDDKDDEEDGDGIPGKLARDILCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEX2</accession>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
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        <text evidence="11">Component of the NDC80 complex.</text>
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        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="205" mass="22887" checksum="24E25C5EE7312812" modified="2013-12-11" version="1">MGMLDEAPHLLLAEVSNSFTTDSDLAAVSRIQASRQQLHTSDKRKIDALHHNLKQLSRQLAVSEASYNDWKAVVVAAEHPKTMIGLDKKKFAVAKQLSAVEGNVLTLEAQLVKLKKELEELDNEDPLERQVLESEDDGTALKLWVYRGLGIEIQDDGKGGFHRASVRNKVTGDFNVVNIENKFTPFFYANYFWGQLASSSDKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFJ1</accession>
    <name>U4LFJ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935539">
        <property type="protein sequence ID" value="CCX10388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="11" mass="1347" checksum="D97DCE9E34140736" modified="2013-12-11" version="1">MGVQLRRLDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFQ2</accession>
    <name>U4LFQ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFQ2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="31" mass="3466" checksum="D8363D98E836C2C6" modified="2013-12-11" version="1">MITSASQFETAHFRLLLDNATTTTLRRVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGK7</accession>
    <name>U4LGK7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGK7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="29" mass="3205" checksum="B57C50BBC0FE9EBF" modified="2013-12-11" version="1">MAKMRDSNKCDGSGGSLRSTLRCLFDQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHK4</accession>
    <name>U4LHK4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936297">
        <property type="protein sequence ID" value="CCX16075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHK4"/>
    <dbReference type="OrthoDB" id="5397613at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="16246" checksum="C08296E9A1717877" modified="2013-12-11" version="1">MHSCILVSPAGNPSYIDLPPPPEFDDNRSIYGRRDRGGQGVEEWDPEMAHLTNQGNRIFAIRPTDGILSSGNVAAGARGFKMAGKELVGLLGKNKWKQMLAMMMRERDRVMEKEMPRNEKSWKTSGRLKRGRPEGMETRWVGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHR1</accession>
    <name>U4LHR1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LHR1"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1435"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1146"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1791" mass="196407" checksum="0E07C7F3ED8DBB2A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHV1</accession>
    <name>U4LHV1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein SVP26 acc. no. P38869</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHV1"/>
    <dbReference type="eggNOG" id="KOG4136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMGTEPV"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="219" mass="24445" checksum="13B1A2416CB0D9A3" modified="2013-12-11" version="1">MWIFPLIGYLGVIIGFGFLTLAIASGLYYLSELVEEHTVLSKKLLIFLIQAIIVIHFLLLIFDGFPLWLTLFSAASHAVYLANVTKSFPEALVVANHYFWFKHFSHPPLPSDHPYSSNYVAGSPYDYSTSSDPYFNERFPTFTEISAFFGICVWFIPFSLFVSLSASDNVLPSSEIGGGSNGAGLGGAGRKKEGMAKTMFNSIKDWFAIPTNTRHERFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI95</accession>
    <name>U4LI95_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI95"/>
    <dbReference type="STRING" id="1076935.U4LI95"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRTQWDE"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="359" mass="41997" checksum="B7EF406B0D73F6F8" modified="2013-12-11" version="1">MNGARSIVANALRPSFSAPAIPTVAARGLRTRTYRFPRWKPGRPKPVYPRVIESMPFQTFQFAREIIAKDSLEKAKAIEAQKERIMKARKEEKPNQHKIKEMEDHLEYLEVQAEINNPRVKYSFDRGIIDMEKPVYRFLADRKWREYRRPILMQRLTQMNVMPDLLPKIEPEVDVQLRFKGKEIHPGDFVASFSSENKPTLKVISFKPQKMLCTVAVVDLDVPNVEKDRFDYRLHWLVSNIPLSHTQTQAFGTGAKPSDQIVQWLPPHVQKGSPYHRYALVLLKQEDRLDAKALKESNIKRDGFVLRSFQAKNKLSPIGAFMFRGQWDTYTKELMQQHNLPGWDQQFVRINENKKEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LID6</accession>
    <name>U4LID6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LID6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2467" checksum="51281863C3D0F6AD" modified="2013-12-11" version="1">MTSQVVPSRSFLMVPEITISML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK63</accession>
    <name>U4LK63_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Glucan endo-1,3-alpha-glucosidase agn1 acc. no. O13716</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK63"/>
    <dbReference type="STRING" id="1076935.U4LK63"/>
    <dbReference type="eggNOG" id="ENOG502RZ85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHDAWRA"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF44">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651506" evidence="1">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="420" mass="45747" checksum="92E0DE5C9170C63C" modified="2013-12-11" version="1">MRLSIATAAACLLGMLSTAMASNERKVFAHYMLGLTYGQTASDWALDISTAKAAGIDGFALNAGPNDSFGDQQLDLAYKAAEAAGFKVFVSFDMGCCGAWDINKVVRWINAYKGSTAQYKVNNVPFVSTFEGPTWADQWANVRSQTGGIYLVPDWSSLGPNGIAGQLGKIDGAFSWEAWANTPGPKTTDADRAYRSTLGSKSYMMGVAPFFYTNIADYNKNWYWGPETLWFDRWEQVLQIMPDFVQIISWNDYGESHYIGNSRESSIIPQAKRYASGIPHDGLRMVLPYYIASYKAGARVSIPNEGAVFWYRTSPKNAGNDGGTTYGPSGTTKAIDAINDVVYVMTLSNTDTSVFVTIGGNGQQFQVKKGVDIVKMPFNSRTGQVRVVMQNGKNGVGAKDIVAYPVNGNVNFNPVVGQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKB0</accession>
    <name>U4LKB0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to U3 small nucleolar RNA-associated protein 17 acc. no. O13878</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKB0"/>
    <dbReference type="STRING" id="1076935.U4LKB0"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRIDGPH"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="947"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="971" mass="105677" checksum="91E88EF3174CCA1F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKB5</accession>
    <name>U4LKB5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKB5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="28" mass="3195" checksum="CC1BEB589FBF9887" modified="2013-12-11" version="1">MWFDSLKGIGTLLLMFDATYQDSHMGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKU9</accession>
    <name>U4LKU9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Levodione reductase acc. no. Q9LBG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935839">
        <property type="protein sequence ID" value="CCX13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKU9"/>
    <dbReference type="STRING" id="1076935.U4LKU9"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQGWNIG"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="262" mass="27518" checksum="47DFF018F4C3CC4A" modified="2013-12-11" version="1">MSGFENGVALVTGAGSGLARGVVLEFVRGGCVKIVAADIIPERLAETAKLVSEINPAARVITVPTDVTNATQVQNMVDTAVKEFGRIDYSVHCAGITGGAARTDEMATEEFDRVTGVNLRGLWLCEKAVLGQMKTQEPRKLSNGTSARGAVVNMSSVLGLVGYRVQSPYVVSKHGVLGLTKADAVDYAADGIRVNAVCPGIVRTNLLPEGAWEHMGAFIETLPMQRLGLIEEVAAAVCFLASDKASFITGTMLPVDGGYCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL51</accession>
    <name>U4LL51_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Cystathionine gamma-synthase acc. no. P38675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL51"/>
    <dbReference type="STRING" id="1076935.U4LL51"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CITETIG"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="560" mass="61597" checksum="A96225E4C58F34BF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLH7</accession>
    <name>U4LLH7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Linear gramicidin synthase subunit D acc. no. Q70LM4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32427.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLH7"/>
    <dbReference type="STRING" id="1076935.U4LLH7"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWILHSS"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="528"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32427.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111294" checksum="FFFC586D1BB5C18F" modified="2014-03-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLN5</accession>
    <name>U4LLN5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLN5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4858" checksum="98D2FCEBB3477BA1" modified="2013-12-11" version="1">MFNNSLQNPRFPWLLITYYLARSNGFPMCYFVLQLGHVFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLX6</accession>
    <name>U4LLX6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_14189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLX6"/>
    <dbReference type="eggNOG" id="ENOG502S1BM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDNDKCE"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="31918" checksum="61EE31383AE4D907" modified="2013-12-11" version="1">MATTTTAIVETELQPVPLNQSSRPSSISLNTPTRSQTPPPRARCKSVSFTAGSAFQEMAGITRTQSLQLNLPGLQRSISPRTLIPGQGPGPTATATPPPSTTSLNSRPGSQSSNEPPSSPNETTAITGTQSARSVRSYSSVSSNHEQQQNRMKSQRRCTNMDGLFLKLGAIELENKGSVARDHLALERTFLAWLRTSLAFASIGIAVTQLFRLNTATAPKDTSDILKHIGKPLGATFLGISIMVLILGTNRYYESQAWLLKGKFPASRGSIFLLTAISVSLIVVSLVIVLTVSAGKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LME6</accession>
    <name>U4LME6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LME6"/>
    <dbReference type="OrthoDB" id="5317438at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="449" mass="50195" checksum="73149F85B0BA251E" modified="2013-12-11" version="1">MPPDLRRRRPLSDCFARLRRELDGTKSTRRYVPPELSSYYIDDLEPTLQIRDYTILGETTTAPYELITIPSVRPPNFDPFSPRLPHREPDAALTYWSLSGDGSERIERSTQGETPRLQISHTTSHLPPDYAASLQSAFTAWHKPSSQPLQVLVWSQLLSSPKIPRDYLGEETPTTFEFRCGGQSCHTELPMPLAEDGILVCFSDSVGERVMVKMLHDGMLWVYEPAGGTAEGAHLIPDTVAWKTLKPGDDYMATVSDDMANAPTTVPRIRTLSLRALAKQFLNSTKKLKGITPEFQDISSIFLSPKKPRRTKPGVWGAEMATMIAFGGFERSTGLYNLLVFMLQLSPQQQDSQTKGHPRVKVVLARAYAGLPPGDSGFASALMCAGLVTYEEIHKRRGSPFGHDCERNCRRDEVSVRYPWVLGANTAEKIRCENLGINIMGWRGQVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMN7</accession>
    <name>U4LMN7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMN7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="69" mass="7715" checksum="23F21AC211D61AAD" modified="2013-12-11" version="1">MIPGEFSKRSEEESQQPHPRNLDAAHAQGRVKLCAHKLLVGCAEFNVEYGKCVEMHTMGVPGNKQAMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN53</accession>
    <name>U4LN53_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_01034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN53"/>
    <dbReference type="STRING" id="1076935.U4LN53"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERLRYMD"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="387"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="212"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="668" mass="73287" checksum="C3EC369377D8AEDE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNG8</accession>
    <name>U4LNG8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNG8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="25905" checksum="D3D71F7596D35674" modified="2013-12-11" version="1">MDHLQATPADRHDQIIDGHDLPVDLRDGHIFRSELCRFSMPTNPHPIERQIICLRLPHKKQNCSNNLYVGKDSTDKWVSGICHWYQPSTNGRKVFTIIFLPFREYHDQQQASTETIKRVHNGVSVSSMHAPAVYNPSIGFGPLDTGRFKTKESCYVDFSPTAKARKIDIEWDAPWYRFEEFGSNHRFSEVPAVQHEQLMNMDRQLRYSNGNQFNLAMEGDGANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNY2</accession>
    <name>U4LNY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNY2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21134" checksum="6C384A5BE37AB2AE" modified="2013-12-11" version="1">MSSIDKRALRIILTGSKNFNDWLMRMAIILVLAECYEFADGTASPPQAPRTATVLNNTPNFSSGNQQSQQQNAKDLLQAAARKETPSPQGSAHQAGHQSFFTPSIPRCRNDAYQVTCFGSLPPMANDPFDQNLMLEPEADIDDPQYESLYECYLEIPKVDFAEKRCSRPDQHNIGPRSPPKVLSYRKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP53</accession>
    <name>U4LP53_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP53"/>
    <dbReference type="OrthoDB" id="10510856at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="294" mass="32264" checksum="14991FA2FCB0FC8B" modified="2013-12-11" version="1">MDSGDSPSSSRSQSPLLPAGEPGTCTIYFPHQQPNTAQYQTWLANRNKGPVNDPVTFIESSKYNSRGFICYECGRSKEWEDVMAGVGMRVNSGFVVEEMGGLSLGINSAADPDTTERPAGEYAGLPGLNTAMQNVTSSPVSYRASESLPLRPAGVQLELVTNSTINRFSDPGPVATAPPPIPPRKRPVPEILKHRVEQFASFEHSPNHNCKPDRASVVGIWGDGELVRDIRDWTQWAVDVQFAMKKPMRWEKWVGPGLFNEKSGNAYQMGICGELVGYDGDWMGLQSGTARWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP84</accession>
    <name>U4LP84_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP84"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6218" checksum="C00407D8C9B85280" modified="2013-12-11" version="1">MLPKLSIPSIASGFMLPDHTSTACTPCYATKRKNWTVHAGCLGGGDGDGDRAMFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPA4</accession>
    <name>U4LPA4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPA4"/>
    <dbReference type="STRING" id="1076935.U4LPA4"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="1">
        <location>
            <begin position="289"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="492" mass="57892" checksum="0A254E8EA45E0CDD" modified="2013-12-11" version="1">MNHGMPYVTGPVDPRMQAHLYGGYVQPVINQGIQQYYDAYGNIQYYQQQYYPQQAYAYPQQVYEQQVYEQQVYEQVPQPELEPEIDWREVLRRVVDSKCETVQTFDTHFKAYLREFSKLFTEKKIKEDDLDQCALILQRSPAFSAIQTRPGDEYKKALNEAQIQDHLVERLDKAADDLQLLLMLKVLRVCGKRDEQTTGKVRTMFKAMAVSDVAFKCVTERIMNQPYDSVMRLTCLRLCHEMIRPTIVFKILLTTYVTMDFLNHLLSVIVEYSWDEDESEYGELDPYHNAFRIITSLSEQYLVQGCPLEENPIHKNLQIDYMQPKRSFSKFGEKIFYILNRERDHRSVCQILMLLHSLIGSPIKEDQVLILYRNDLMVLIGILLRYLNDNDEEEGYVRVHEYSIRLLEDLKNNTDLCDSDSVRMDGNGGQNQRDQIYYTLKRIIDHSSGHTLRLAKRCWQVWFEEKKTLLSPYGNPQHATSATSFGHVDKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPR5</accession>
    <name>U4LPR5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPR5"/>
    <dbReference type="eggNOG" id="ENOG502SQMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5330919at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="856" mass="96129" checksum="B9E6EA432C2C2C3F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPX0</accession>
    <name>U4LPX0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPX0"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="11623" checksum="EC67877E29E87C5F" modified="2013-12-11" version="1">MIPGALLLTNCYICSGSRSTPACTTYPGRKHTYGAVQHVRGTRLRDTKNRILETENGVLLRKGKLWVPQDMVETIMKSDPDMKMAGHFGQDKTIELIRRNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ26</accession>
    <name>U4LQ26_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_03241</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ26"/>
    <dbReference type="STRING" id="1076935.U4LQ26"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHVGFNY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="18">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="19">
        <location>
            <begin position="116"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="17">
        <location>
            <begin position="240"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="697" mass="77984" checksum="D0C1C1FF26B84FEC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQR2</accession>
    <name>U4LQR2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4293" checksum="525A139A33C8006F" modified="2013-12-11" version="1">MKRRRILPTAKLRILLIPTKYLVRENRSQSAKADNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQY0</accession>
    <name>U4LQY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="192" mass="21617" checksum="4F27025930DD6BCE" modified="2013-12-11" version="1">MLDTDGLLQFPRRSPKVLWIDCQRVDIQSYFYHPVGPEWNGMVKYIVRALLGHRHPKGSAVLRLDPQFPRRSPNVYGHNGLTVGDTRLLWPPTLLRTTASLQDEDTGEPGDVEDIATIWPHTCVFRAITINLDGSQAIFSEFHFVKRLEIEAWVMDSGASTSICSNFDCFLPGSLEHLPSILSTRMGDNHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR98</accession>
    <name>U4LR98_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR98"/>
    <dbReference type="OrthoDB" id="10421627at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="49093" checksum="8A91B5AA94D626A5" modified="2013-12-11" version="1">MASIDFYCPSYHKQQIIDNCKYLFGDDIDPILVTERYDVTNDENYAIVYNRTIQLDETCVRACVVDRTHSDTSILSVADASQRTLSYSSPTKGKVNLDSSSSFPRNTYQSVVKTYEAIQTLHQLTMNLVTDKAAQEVLLNNKLKEGVEEKLQRLTAETEVDDTIKEGLRQQLYKRARASFKRKEEKRKNEIARKIQDMLDTLDDEDEDDYDAAMDQIILRVQQPSKITTSQNEIDWRGEHVSNIVRDCQRKFREKLKQQKEELTKKFEEEIKIAVQEARDVADQKLVDLQLEHEGVKKTYDETIEGMKQDRTHSDAEKDASIRDLNGELDAKVQALEKACSSVEKEKGFRKKLEDALDVLHQTEMERKQELAEVKAELQRNLQQQHTRSTTTDDTENTDCDTVTEGSQYTPTGSTIDGSTTSTVYGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRE6</accession>
    <name>U4LRE6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936618">
        <property type="protein sequence ID" value="CCX34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRE6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5206" checksum="D0ACEF9E0DA0DE94" modified="2013-12-11" version="1">MRMNLEGVSFTSIQVHSNIFSTVLRRVLSSSCRKRQGHHPDIVGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRJ5</accession>
    <name>U4LRJ5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="HF936389">
        <property type="protein sequence ID" value="CCX34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRJ5"/>
    <dbReference type="STRING" id="1076935.U4LRJ5"/>
    <dbReference type="eggNOG" id="KOG3143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GIPFFDH"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="214" mass="22871" checksum="585176837DD95A52" modified="2013-12-11" version="1">MSRRTATINRNTNETKIQIAISLDGGSLESLDDKNTEHAAQVSATQSINVNSGIGFLDHMLHALAKHSGWSLALKCDGDLHIDDHHTAEDCALALGSAFKEALGPIVGVQRFGHGYAPLDEALSRAVVDLSNRPCATIDLGLKREMIGQLSCEMIPHVFESFAQNAGITMHVDVLKGSNDHHRAESAFKALAIALKAATTRTGKNEVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRL0</accession>
    <name>U4LRL0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
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            <end position="215"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
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        </location>
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        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
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            <end position="164"/>
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            <end position="182"/>
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            <begin position="199"/>
            <end position="211"/>
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        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="765" mass="81702" checksum="90D031D794BC12E7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRR8</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <strain evidence="5">CBS 100304</strain>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the SPT2 family.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPT2"/>
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    </dbReference>
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            <end position="359"/>
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            <end position="47"/>
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            <end position="86"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <end position="125"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <end position="162"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <end position="225"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="CCX34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="396"/>
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        <location>
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            <end position="34"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="527" mass="59747" checksum="D1373FA3988024CA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTB1</accession>
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTB1"/>
    <dbReference type="eggNOG" id="ENOG502RA14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFAMYLD"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="349" mass="40559" checksum="0641E1D89AAAAD78" modified="2013-12-11" version="1">MSDSSRHHSRRHRDRDGHRERDSSRRRHRERDSSGSRRDSRRDRGRTEKSERPSKKRTRSPPPTLPMNAIPIGTRDFDLLSSVFSSYLDVQKGLNLSELDERMAKSRFKSFVSHYNRGELARGWYERVLQIQLHGAPPVSAPNIALENSINALVSEAAQRAPPPKRSRRDEPSSDEDSSEDEFGPRPPGEEEQRARKGPRAPGFQELELQKELAEEDREAQREDLRWERKMDRKRQKEALEDLVPRAEAGTRERMLEKKKEVGEKMRAFREKSAEVEEVNDEVVFGGGEQTLAQKKAAMERKKNERELRREQILKARIAEREERVQGMKEKEERTMAMLKSLAASRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTJ4</accession>
    <name>U4LTJ4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTJ4"/>
    <dbReference type="STRING" id="1076935.U4LTJ4"/>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIVHHSG"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="10764" checksum="8128ED43D793327F" modified="2013-12-11" version="1">MAPAAAQGGKKQKKKWSKGKVKDKAQHAVAMDKNIQERLNKDVLTYRLITTAVLVDRLKINGSLARRALADLEAQGVIKKVIGHSKLNIYTRDVAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTL7</accession>
    <name>U4LTL7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTL7"/>
    <dbReference type="STRING" id="1076935.U4LTL7"/>
    <dbReference type="eggNOG" id="ENOG502SJEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CISEEHF"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="485" mass="56183" checksum="78DCDE2A568110C2" modified="2013-12-11" version="1">MSTNTFEWCNYPKLRNIKYDPIDVNIDKYYQKFHDKLKSGDLVENGETKQVTNIQAITPKKPQSAASENQTEVPDMAWESYDEFESLEKGSRSTESLYIAISPHFSYGKLQISREALLKVLSNYSVFPNFLDVLQTFGAKTERSSDEFGVYYQHSSERCFQVCYNLKYIGYRPNYNNPSSPPLHAARKTGLWAMYDYKSKRSVWILLQPSEDFKERLCKNERLLSFMDVHRLQLACAEENIKDYIEYLERNFIKLRDEACTAWKQTMTPSIDDARKLHIQRDQLLHLEYILTLNEYVIRRMKEGFGRLQGANNAVHTQKSELKAFQTSLSNSLGKIEYYRKRVEGLNNRCGSLAALVSGLPSLVSNEILAHILMQIQVPIILASQENGVMRAMQVKAAEYSRSMKIVTFLTLVYLPPMLVASVFSTDFMRHWDAYISLAIFLGMVTGLMILTFASYVLWRRWESRNRSQLSQDVEHGIMGNDFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTM8</accession>
    <name>U4LTM8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTM8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="3803" checksum="84CAFA8FE4ECCA29" modified="2013-12-11" version="1">MWGSVSSPSVALLVTFRSKLSAKLSLAPIPDPQVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTN0</accession>
    <name>U4LTN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B acc. no. B2RXR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTN0"/>
    <dbReference type="STRING" id="1076935.U4LTN0"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESEHPLH"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="180" mass="19892" checksum="87841DC845AA28C6" modified="2013-12-11" version="1">MNAKNIVDWSPLHYAVTRESLVKDSHEKIITDLIQHGADLDAKDIADLTPLHYAALHGNTRVAELLLRQGAQSNIPSRSGMLPIHCAVKGGSLETVNLFISIYRMDINAVDHIGWTPLHYAVWNGHDSMVELLLTAGAGVNCEDKFGVTALLRAIQNNQPSIVELFLRLLPETLHQAVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTN8</accession>
    <name>U4LTN8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to endonuclease/exonuclease/phosphatase family protein [Ogataea parapolymorpha DL-1] acc. no. EFW96320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_14010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTN8"/>
    <dbReference type="eggNOG" id="ENOG502RYM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DSMPDNI"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652633" evidence="1">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="42752" checksum="EDADC0DAB3354CDA" modified="2013-12-11" version="1">MVRISSFLIFLPTLILTTLATPSQPTLTAVPIRFLTWNLRYDSLPNSIPINSTLSHLPPHLPLDSSIIPYASPLELPWSTRRLAVAREISFNRPDIICFQEALQRQVTDLQELLPGYEHIGVGRDDGKTKGEYEAIFWRRDRVGLMEGDWDTFWLSGTPMEPSKFLGAGSVRSATRGRFMVYPASSSGYGGYDDDATEMKKRSNVTRTDQGKELTVICTHWDDQSDAQRKLAGSLVRMRGAHELATTGNPVFVLGDFNSPRQGVDSGGYQIITGKAEEVKVNETFEYNFGGVKKGWGFLDLAEETHPVGRSGHAFTFTGFKRQGSMDVSRIDFILGSQVGTNSSEAQAQGNGWKVERFRVGENWYDQEGMASDHRPVYADVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTU5</accession>
    <name>U4LTU5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTU5"/>
    <dbReference type="OrthoDB" id="5495477at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="9912" checksum="5DC6DA47CFCF4F90" modified="2013-12-11" version="1">MAVATFEVHSDVKKTRCVNLGTGYLDATEFQEALRLARNTIEEIQIDADFEPNYDTTGVIGPFKDFPKLNKISTEIESLVPYPGTPGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUA8</accession>
    <name>U4LUA8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUA8"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="452" mass="50602" checksum="E46BF272BFF1A904" modified="2013-12-11" version="1">MAPKIPEFETKVAEVCHIQWLNRELASMVNACLMSPEQGDYLFPWSGNVYDDLGIDGTRREENDVGIRPKGRELPTVIVQSCWEKSYDQTYREMKDWMYCDAVKRVILLKWTNGVEAPDCDMEMFEYDSNAPDNFRRTMEQKILPPPPSEMKGIKITVGELFGDQIPWADLHPRLAYYMSTSRLGKISLEKFENDMESYDEMVADMAENPQDYEPDTEDSKVATPPVEMEMSDPVDKPDQPAQTSQTNANDEVCLKCESSRCCGKEASQKHLDDTAKPQPPKSKYDAAHAQKLGPFELLGFRINVELEASPSDAADPSFAERKAKLVQTMQWLTTMIGQGGENVSINLPVLPRAAYLTTLPLPAPLRPVTALENNSGDSEQASSKGKEARKHKRESSKKSKSSQSSQSTSSHSKRIKGDCSEGDSAYSASSSDDAKSKPKKQKLQKTTSKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUD0</accession>
    <name>U4LUD0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Smr domain-containing protein C11H11.03c acc. no. Q9UTP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUD0"/>
    <dbReference type="STRING" id="1076935.U4LUD0"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYIFREN"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="254" mass="29111" checksum="38D467579AB09C18" modified="2013-12-11" version="1">MSYPMTQLGSRAISHYNASPTTDEEEREYDRLRDLARSEARKRAQLSQQSQQAYQSGNKAAASDLSKQAKKHAAKMDEYNRQARDYIFRANNHDQPEDTIDLHGLFVEEAEEILEQRIRAASSRGEEGLHVIVGKGNHSTNHVRKLAPAVERICQEQGLKHKEEENEGRIYIWLRPGTGGENVTPPGWGQNQQQHHHHQQQNHHQQPNYHQQPQGGYPGHQQQQQHQQPDLVEEVAKAVLPKIFKKMGECCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUE5</accession>
    <name>U4LUE5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUE5"/>
    <dbReference type="eggNOG" id="ENOG502QWJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITYRIWE"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59733" checksum="C8F5A3797C9A66AF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV87</accession>
    <name>U4LV87_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV87"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651822" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8584" checksum="4B3A1FA59F70F6ED" modified="2013-12-11" version="1">MIQNRGSFHLRTTHHVTVTLVLISRLSTLTKGRPRPRSYTRTGGIKVMKFKSHVQNSCAVTSPNNCGAHVRMTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVD3</accession>
    <name>U4LVD3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVD3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10321" checksum="45458C04CBCA139E" modified="2013-12-11" version="1">MSFEPGLSQWPTWSYFVLGAICAAIYTILYRPAFADEAVDAIMIDICICALVWKVISLCDQPDYAWSEVVPYLLWIAIVAGLPHQGQRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWY5</accession>
    <name>U4LWY5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat-containing protein C6C3.08 acc. no. Q10311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LWY5"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="248" mass="26796" checksum="FB64FFE176F9E622" modified="2013-12-11" version="1">MNTPLLPERPAIHEAAIKGNLAEVEKLLAENPKLANSVDDDGRLPLHWAISSNHKAIVELLHSTKGFDPDAPDTRGWTPLMIAASIKDGEEIVKLLLAYGAMVNAQNDSKQTALHFAVSKQNTEVVKLLLSAPHKASTRILDIRKQIPIHRAAAVGSSPLIRILLDNNSSIDPIDDYGQTPLHHAIAEGHGDAAVTLLKRGAKTDGKDKEGKLAIELAPDRKVRLFVSNAAKAENIAITMPEGMKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX96</accession>
    <name>U4LX96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936511">
        <property type="protein sequence ID" value="CCX34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX96"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7599" checksum="5BCE11C15050BDBB" modified="2013-12-11" version="1">MAKSYSREHITPGSYRRFRLLCSRYRIEQDRPVSNSVPLLTAVQLKISCCVPDAVDLIRPRYNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXE5</accession>
    <name>U4LXE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXE5"/>
    <dbReference type="OrthoDB" id="4778791at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="14378" checksum="A29D5191040FE6D0" modified="2013-12-11" version="1">MREILLKAKNNEPYNHILSATRGIMFFGAPHHGMRSEDLTNLVNSQLEGRVLESKRKLIDQLRTNSVFLDDHNADLTSVWDQLSGKVTGFYETENSPAMQKARLIVFLLTRCFFLMIHRIRMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTS8</accession>
    <name>U4KTS8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTS8"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="150" mass="16139" checksum="63E03F42E496D5D3" modified="2013-12-11" version="1">MADPISFGASVLGLVGAAQKVGELLYAFGSSMVNAVDSVTKLNHEIESITAVFRVLGALVFQKETQDIIRLPPSPVQPVIETLLTSVTGCVLIFSELENLLDEVGDVNTSVWDKAKWATREGAAKELQAHLERHKATLNLALSALNIAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUA2</accession>
    <name>U4KUA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to tRNA ligase acc. no. P09880</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935195">
        <property type="protein sequence ID" value="CCX04271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUA2"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EFTSHIG"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="4">
        <location>
            <begin position="68"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="3">
        <location>
            <begin position="417"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="583"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="666" mass="76192" checksum="C468894B11C97744" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUF5</accession>
    <name>U4KUF5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUF5"/>
    <dbReference type="STRING" id="1076935.U4KUF5"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCVWIND"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17323" checksum="5CC099350522FB2F" modified="2013-12-11" version="1">MSESPGRGLRLLSLDGGGIRGVSELVILHEIVIRVQAKRGLSKIPRPYKYFDLIGGTSTGGLIAIMLGRLRMSTAEALTAYGQISSIVFSAKKFFLQDGGFKATVLENAVQKIIMKYGEHHNKQEEILDLRHGSNGGKTCVWINDQWDWLPVITLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVS2</accession>
    <name>U4KVS2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative esterase C31F10.02 acc. no. P87304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVS2"/>
    <dbReference type="STRING" id="1076935.U4KVS2"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KQIMRAM"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF57">
        <property type="entry name" value="PAAI THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="17845" checksum="2F297257A0EBBD30" modified="2013-12-11" version="1">MSPKTLNFVRGVFTSFLQNSGLEPTLLRGLVITAAIPGKVSFELPIEQQHTNRLQILHGGTIASMVDLGGSLAVASRGLFATGVSTDLNVTYLSSGGKVGDRILAEVTCDKFGKTLAYTNVVFRNEKGEPVARGSHTKYVVNAWKDPANIVEEIKAEEKALKDQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWJ4</accession>
    <name>U4KWJ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWJ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13619" checksum="F3DEC42EA7BA5198" modified="2013-12-11" version="1">MNQMQSLMKMLDCALLKNIACHKLAEIIYHDNKNNCFDILKFSKCVRETYSATYNGDNLMRKVIVYAAANFDSLAHGLLNSPNFKEEFKDHGDFLAAWISKLAKKWRKGATNERAPFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWU1</accession>
    <name>U4KWU1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935266">
        <property type="protein sequence ID" value="CCX05701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWU1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="29" mass="3391" checksum="0B8A224B768686FC" modified="2013-12-11" version="1">MGVSDDRYARLSRNQNKTASRFDAEFQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX24</accession>
    <name>U4KX24_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ATP synthase subunit g, mitochondrial acc. no. Q12233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX24"/>
    <dbReference type="STRING" id="1076935.U4KX24"/>
    <dbReference type="eggNOG" id="KOG4103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMTPPNL"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX06517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="175" mass="18601" checksum="544FE5745B48AF53" modified="2013-12-11" version="1">MRSSAIRVARQQMLFGARRNASTSSPVDAAKVKEQATAMAGKATKVAGEAAAKFANLAASTGGRTGAVLKKIQAAIPPTVYYSKVGIELAKLVFRGQKMTPPDMATFQSTLKSFAQPSTMSAFYKQAVESIRTCNKADAAFVGVLAAEILGFFTVGEMIGRRKIVGYRGETAHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXL9</accession>
    <name>U4KXL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXL9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="142" mass="16241" checksum="016317852C62717D" modified="2013-12-11" version="1">MCFFRIFDYRQYGCGHNPIIYQEPCQIAKAAYTTNGKKPPCARTIAEYGGTERNYCIDITPPEPEGKITLHARYLNASAPANWDTCDIRNKDVFLKQGVVYEMTACEKCTSPKIGESARVVDWSQCDDVWYEEVMEGFQDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXR1</accession>
    <name>U4KXR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXR1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="8205" checksum="690320B575A984CE" modified="2013-12-11" version="1">MDNYHKAVATQMLAVAKGFEMFKWIPALWKYLSTDLEVARHSRRPVMFLPTVHHTQTSTCSVLESRVIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYR1</accession>
    <name>U4KYR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYR1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4654" checksum="04C55B11BFB2E27E" modified="2013-12-11" version="1">MHFEFRIRATTSIAEARRCEVRTSLWMNNCCGLTSSHSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYR9</accession>
    <name>U4KYR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYR9"/>
    <dbReference type="OrthoDB" id="10441574at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="20782" checksum="CB98B098D9FB0B84" modified="2013-12-11" version="1">MAIALIVMRKLASGSKVVTRIRGLSIRTGIRGFFKTGTPGIVLVSTPKELDPPDLPGPDLENFKGYVYTIGGYDKKDKQIQIQHEAIAPRMSIAFEKEKIRRQFDIPKIIEEAERLGSGGDITKWLNKELDNAARHFTSKRDKNWYDVWGDGSTKKHVSMKRSTVQKKNEEGEVFTIRKYFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYS6</accession>
    <name>U4KYS6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935315">
        <property type="protein sequence ID" value="CCX06820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYS6"/>
    <dbReference type="OrthoDB" id="10338661at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14634" checksum="D13D39ECE03DA31D" modified="2013-12-11" version="1">MSSSSNYRRSQRQTVSSSQSSSLVPANASNISSVLVPVNIVSDSLPCNNFVLQSSQCCRNGQQQVTDHTGPSTMGHRSARGRTIAVWYCCWQPQSPAHHGGPYICDTTDACQECGHPRCNSCVRRQEAVAEHCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ39</accession>
    <name>U4KZ39_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UPF0587 protein C2D10.03c acc. no. O74797</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ39"/>
    <dbReference type="STRING" id="1076935.U4KZ39"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="18476" checksum="D59627920ABF9E0D" modified="2013-12-11" version="1">MYYLKLTAELEGVTDLRPQDVEGDPFFYMFKVTCLSCREEHDNWVGVSRFETRDISGSRGEANFVWRCKNCKRESSATIKGAPTAYVQQEPPKAQRILEFECRGCEFSDFKPEGNWEAKGIESGTLFKDIDLSEGDWFDYDEKAGAEVSIKDQKWEIVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZT0</accession>
    <name>U4KZT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX08025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZT0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6263" checksum="B08C6AF652B8F22A" modified="2013-12-11" version="1">MTGDPIGDYTEDTEDHIEKQIEDNTEGNIEETTRDIVKNGMEGNQYTEAIGSEAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Z6</accession>
    <name>U4L0Z6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Similar to Retrovirus-related Pol polyprotein from transposon TNT 1-94 acc. no. P10978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_07517</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Z6"/>
    <dbReference type="STRING" id="1076935.U4L0Z6"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4368647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX07928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="22438" checksum="77D6B73E281DBE3A" modified="2013-12-11" version="1">MGHAPAPDVYEAQTSTVVAAYKQYLTEIERLGKVTNSDFSILRFRCDNDRGAFDNTEFRDLCTAHGTAIEFTPPYTQDKNGVAERLIGVIVQRARAMLIDAQAPVEFWAEAVNTAVYIHQRIPSKALSSKPDSDGLTESPSITPYDMLHMWGKKVYEITEKPLDNLHRFGCVAYKMIPEEQRLNKKFGERSRRCMMGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L156</accession>
    <name>U4L156_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L156"/>
    <dbReference type="STRING" id="1076935.U4L156"/>
    <dbReference type="eggNOG" id="ENOG502S07J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HVECMNR"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651224" evidence="2">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="319" mass="34597" checksum="120EF3B571C17ECA" modified="2013-12-11" version="1">MRILQSALLLFLLLREAASYEKADGSETTELLTYREGDLVELQCLNRTIDTGEHITDKTGKLQYIPFAQCNETGAPLELRFMEGEGINAQPGLNCTIPVVTDEMYHLLEFYVHHDSPLSCRVRARPQGSHRALIETEEGDSGSGGIEWVPLIFGLTGKLESSHLHIANRINLLFHMASGLPGVIDSAAAYSTSAVTASTRIIIGDPLPLHLRVRWYESTNLPLGELRVNVIHGAGHMLFYCLLSAIVGAVGCYAWVVGVDVPRRLRRVTMGMKGRTNGANGGIIGVTTDKIKIGYNGGYAFPGAGNGGGYGYPGAKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1C8</accession>
    <name>U4L1C8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YJR142W acc. no. P47173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935406">
        <property type="protein sequence ID" value="CCX08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1C8"/>
    <dbReference type="STRING" id="1076935.U4L1C8"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRRLEYP"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="38446" checksum="4DC6B976F514DBB2" modified="2013-12-11" version="1">MSPPYTYLDLVNQVDSFPNAILHPVRHAERLTALKLFTSGSHTLGYMHDPIFEVLKTTAAHERSEKGYDHWVITANTVSIKGESVEERSRNIKKTLDHWREMKTFEVCSGKGWRNELYPVYSPNGELFLEMERSAACLFGVVQYGVHMTVYVPGATTDDMRIWTPTRHATKSTYPGMLDNTVAGGISSGMTAWDTLVKEGHEEAYLEESLINEKAKCVGSVSYFYERDANAGGESGLLQPEVQYVYDMAVGENEVVPKPNDMEVENFVLMPLAEVKKNLEEGKFKPNCAFVLIDFFVRHNIITPETEADYIEICSRLHRALEFPLCRSPAAKKHVHAHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1J2</accession>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX09732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4604" checksum="CB08DC0D6E907655" modified="2013-12-11" version="1">MAELDVLELLGHSTCQPLEFHLGSDLDLKALIRAPRAPKYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1U1</accession>
    <name>U4L1U1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935282">
        <property type="protein sequence ID" value="CCX06208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="11314" checksum="9D1021D490513EDF" modified="2013-12-11" version="1">MPLRPVTGLQQEHPAIVFLRSCVPGFLHWMKKNWCWVGVNKTMLWLRGFGCVLSGCVECFGLGPVLYVGYDRYLQRTWATSSSKQAYKLQRNARGPKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2H6</accession>
    <name>U4L2H6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935197">
        <property type="protein sequence ID" value="CCX04275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5142" checksum="24CEA07C5F62762F" modified="2013-12-11" version="1">MVSCGDLSGLRRLLAERKVSLSDCDELGRSLLTIAYLSVKPAICKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2X9</accession>
    <name>U4L2X9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935493">
        <property type="protein sequence ID" value="CCX09710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2X9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="10002" checksum="0D3B4BCBB2C1EECE" modified="2013-12-11" version="1">MEQLLKAPANTVSSLEASRSPAKNLVKDIKSYTMFKFVYRGYVGEQLRGVVMRLERYDKSVKKTHETLMTLLYPSLQNCHLLCRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L375</accession>
    <name>U4L375_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_09571</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935501">
        <property type="protein sequence ID" value="CCX09978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L375"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QDMQYWA"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX09978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="564" mass="63763" checksum="C4BC88D44F9226C2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3W7</accession>
    <name>U4L3W7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="HF935621">
        <property type="protein sequence ID" value="CCX11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3W7"/>
    <dbReference type="eggNOG" id="KOG0632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010273">
        <property type="term" value="P:detoxification of copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.30:FF:000001">
        <property type="entry name" value="Glutathione gamma-glutamylcysteinyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447:SF2">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="16"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="430" mass="47649" checksum="265E8BD3EEE79243" modified="2013-12-11" version="1">MLNTPPPVPVPVEGKKVKESFYMRELPTDKLVGYESPEGKELFKAALMEGGLEAFFPLSQQFLTNKSSQSTVCGLGTLCMILNALKIDPAATWRKPWRWFTQEMLDCCRPLDWVKENGITLAEFTCLAKCNGLDASTRFADETSFAEFERAVRACTFSTGQLMAVSYSRATLGQTGSGHFSPVGGYTSKNGGMVLILDVARFKYPSYWVPISTLYSALLPPDAVSNQPRGYSILRRPETPVPPSLLVLNATKPTWPLLYTPLSKLCETASSYHELTSALGAILRSPSGLPTVSSRYEGSHHSILTSLSKSPSFDTTTCSEAHTEYRQGVASLRRYFRENSVLYKELELDELWKTEITVFILALLAVGDVRRRLGAGVREEVERRLQGDYEDERIGREVEGVRRQMESLVELGDVECRREGGCCGGKGTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L484</accession>
    <name>U4L484_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L484"/>
    <dbReference type="eggNOG" id="ENOG502S55X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651646" evidence="2">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="26035" checksum="20AA07A2E2408FC9" modified="2013-12-11" version="1">MTPLQQLPLFVLAVLALLLGVKANTEKEIFLAPRWQEDQGVGDHLPQLMPSEHCRNCRSARLRLETDFTNDHEFFEDLGKQHWIRIDGLKEGQRYEVRVCWAATQPTDFKLDLFEPEEVLHDEDWLLAQVGKYPSISQAEVVKREGSTLFLRVFAKTAYFSANKTRMENPEPVDVDIILDPYVFNVVPESLLAIIGLIVVVAVASWPLGGWIHKVLTGVGRLDTEKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4C5</accession>
    <name>U4L4C5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Ino eighty subunit 1 acc. no. C8V8H5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4C5"/>
    <dbReference type="STRING" id="1076935.U4L4C5"/>
    <dbReference type="eggNOG" id="ENOG502QVDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DAHAYKQ"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="764" mass="85367" checksum="B7F2632BCC6C1AA2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4T3</accession>
    <name>U4L4T3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein PRY2 acc. no. P36110</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4T3"/>
    <dbReference type="STRING" id="1076935.U4L4T3"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
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        <property type="entry name" value="CAP_dom"/>
    </dbReference>
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        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V5TPXLIKE"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651123" evidence="2">
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            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="196" mass="22027" checksum="E8BCBF3F5752C5D5" modified="2013-12-11" version="1">MNFFALSLSLLSITSSALGYQAGMKDGFLNTHNRARGEHGVGGMYWDNNLAAGAQLWANRCQFAHSRGNYGENLAMGHRTASLAVQEWVNERSSYNYNYGDFSAATGHFTQVVWKGSTRLGCGARLCGRQWLYVCRYQSPGNFRGRFQANVFPRRGGAVYRRTNGTETVEYEHTEEEHADADGEWEDETAWVADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L540</accession>
    <name>U4L540_PYROM</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_11766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L540"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651670" evidence="1">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="409" mass="41385" checksum="D0E839B0D2C50234" modified="2013-12-11" version="1">MVAIKNLAVIAFAAVAMAAPMPKIDLSSTNVSNNGNGNKVGFFGNTAVNAGNNNNVGNNANVARDIDLSKTNISNNLNDNVIGFTGNTAINLLNGNNVANNANVARDIDASKTNVSNNLNGNKVGSEGDWTLNAGNNNNVGNSATVVGPRGIDASKTNVSGNGNDNKIGFFGDSTINAGNNNNVGNSANVARDVDASQTNVSDNLNGNFIGSQGNTEVNAANGNNVGNQATVLGPRGIDASSTNVSGNGNNNFIGTQGNTEINAANGNNVGNSAHVARGIDASMTNISDNLNGNFIGTAGNTVINAANGNNVGNSLNVLQRDIDASKTNVSNNLNGNFIGSEGNTEVNAANGNNVGNSLNVLPPRDIDASQTNVSDNLNGNKIGSSGDLNINLANGNNLLNSLNVLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L636</accession>
    <name>U4L636_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935653">
        <property type="protein sequence ID" value="CCX11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L636"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11104" checksum="5C3EE26F5AADA157" modified="2013-12-11" version="1">MYPDLSAAQKEKIHSPEKLTGYMEIINKLGFGVLVVGAGALVCNSPYSQPATQPTHISSSSSSSDPPHDSCALPSHRPPSPPPPNPPINHSPETADGQFYLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6E3</accession>
    <name>U4L6E3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935735">
        <property type="protein sequence ID" value="CCX12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6E3"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651955" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="132" mass="14884" checksum="0067795681533F9C" modified="2013-12-11" version="1">MQFLFPILLTLLALIAPVFSVPHNNHKRSPKNIKKAGGGPGPKVLVCTDENFKGDCEENVMNDGLCWILNGAYKRKVSSFKVEKGCCQFYMDEVCNRPLFSAMNREDATLKGEHNDRIRSYNCDSNKCPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6V0</accession>
    <name>U4L6V0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6V0"/>
    <dbReference type="STRING" id="1076935.U4L6V0"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HENEFFF"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9811" checksum="0D5A528E1A85B04A" modified="2013-12-11" version="1">MCTLPIIPLFRSTSHSARKIKTKFTLRAAIKNVAIFLDDICFVMRLEYNRTVFPTSKSSQDRREVRARDVGVSQAISSEYRALMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8L4</accession>
    <name>U4L8L4_PYROM</name>
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    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX13172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4881" checksum="C3772B9630595746" modified="2013-12-11" version="1">MGWTLEPATFFGSKFAGTLLRFVVMMRMKWQVGGVGGARVMVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9E6</accession>
    <name>U4L9E6_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L9E6"/>
    <dbReference type="eggNOG" id="ENOG502SQ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRHVPGK"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX10191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="221" mass="22971" checksum="8066ADD6C790EA11" modified="2013-12-11" version="1">MLLYALLALFPVLSLAIPGTGCTSIGIITARASTELPGEGVIGSLAQLIQTRSRQTVSRANVDYPALLFPYGTSSAAGTAALKTQLTEAVRRCPDQGIVLLGYSQGAHVVGDVLGGGGGTGLGLKTPPVSTDVSKKVKAFVLMGDPRHRAEQSFNAGTAKRNGLFPREADQSLEGFASSGVSYCDTGDTFCDSGIDTVTHLAYTAKYNDKALQFVLDRIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9X3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="11804" checksum="6C695D30564A099B" modified="2013-12-11" version="1">MTGWILLQDTVCVVVISSIILLKLYILFVALLNLVLYIISFIYSLTVFIAFQRSIKRNQNNAGANIETYSTNGTVNTTASISGQNGELSGEIFAREAPDTELREVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB62</accession>
    <name>U4LB62_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651286" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="8258" checksum="F5EE66868977FAEC" modified="2013-12-11" version="1">MKLSLISLLSALATSKAVPLGPACEKTDRLCLYYCVRKDFRIPCERKFPEFIVCYDLDTRYDDKCIPFCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBF0</accession>
    <name>U4LBF0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_03165</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="436" mass="48050" checksum="98BE8498ECAD6747" modified="2013-12-11" version="1">MPPKRTRKLEVFTEGEPTRRASPRNKRPLTEDARDALPPAKRAALGDKTKAANSRESSFRDGEGPQKGKRTVVKKGGKKGDENSEATRATRAEKKEVKKEETAEEESVAESQAEQAKEKEEYPKEELVDENGIEQPEETEVTTLDKKPKSTPIDQLRQVQEALKLAGISASHLDLTNPQAFAKLISSRDAWTPALLTFICRQPGLTTLDLSMPAPSPGSFSVPSCSPDLLLKPFFSFSISTSLTTLSFRNRYLTTSSISLLRMIPALVSLDLTATSITNHALYHLTVHTSLSLLNLNNNPSITDDVRPVFSALPSLRSLYLRGTSFTTPALRRLVTEDLPKGCRLLSIPAPTIEALNSRGERYCMEIPQGEGYLEDPAVVGNQGVEVLRRNLELHKRCNKDIQTSGTKVELAGRLRGVLEKRRGDEGILAVLGRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBH2</accession>
    <name>U4LBH2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CaiB/baiF CoA-transferase family protein C7orf10 homolog acc. no. Q68FU4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935625">
        <property type="protein sequence ID" value="CCX11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBH2"/>
    <dbReference type="STRING" id="1076935.U4LBH2"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="257" mass="27901" checksum="1FF1113C95DB7571" modified="2013-12-11" version="1">MVEAEFGLMHITGEADRPPVKVGVAVTDLTTGLYACNSIMAAIIQRGITGRGQHLDVALSDCQVVTLANIASSVLISGEPDKGRQGTAHPSIVPYEAFPTADGDILLGGGNDRLYGVLCQRIGEPQWAEDERFLTNELRVKNRKILIPMIAGITKTKTTQEWLDILENCGMPYAPINDIQQTLEHEHVLARDMIKTVHHPTVGPIRLINTPVKYSESTPGIRSPPPTLGQHTDEVLTSVLGMEEEEIRALKGEGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC41</accession>
    <name>U4LC41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC41"/>
    <dbReference type="STRING" id="1076935.U4LC41"/>
    <dbReference type="eggNOG" id="ENOG502S2RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PINRPEG"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="559" mass="61692" checksum="EFF323D879B3365F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC86</accession>
    <name>U4LC86_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_03094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC86"/>
    <dbReference type="STRING" id="1076935.U4LC86"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TGFGCMI"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="62"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX16451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="422" mass="46701" checksum="8D96150D301EB19D" modified="2013-12-11" version="1">MSFTTFNNSFQRVIGYLWDPEPKNTDTMNSIWLLGQEYPSALPAPTTPVEDDLSEAQQTWPRAFLDDFNSRIWMTYRHDFPPIPRSNSTAGMSIMTAVRAQLPVHAQGFTSDQGWGCMIRSGQCVLANALAILQFGRSWRKGQHPEEEKALLALFADDPEAPFSIHKFVHQGELRDIRSGSWFGPTPTAQCIKALADAHSTPLAVYVTLDGNLYSDTFHRHSSSRSNHPTSPQEFTPVLLLIVTRLGLDSTNPLYHEALKATLEMPHSIGIAGGRPSSSHYFIGVQGDYLFYLDPHVVRPAVTFKNPTSPSRPSSSSSPQSPGSSVSSGPTSPGPGAASGGISNEDWESFHTSRLRRLHVKDVDPSMMFAFLIKSEEEWREFRQGVKEVQGRSVVHVGENEPVSSVRDSAVEEVVSEDDEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCB4</accession>
    <name>U4LCB4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized FAD-linked oxidoreductase ygaK acc. no. Q796Y5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936658">
        <property type="protein sequence ID" value="CCX17478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCB4"/>
    <dbReference type="STRING" id="1076935.U4LCB4"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VAQGMTC"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651316" evidence="3">
        <location>
            <begin position="19"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX17478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="645" mass="69701" checksum="CA27A35D15F1EAEF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCD1</accession>
    <name>U4LCD1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to N-alpha-acetyltransferase 30 acc. no. O74311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935385">
        <property type="protein sequence ID" value="CCX07977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCD1"/>
    <dbReference type="STRING" id="1076935.U4LCD1"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22628" checksum="8AEEF89B92E99C5A" modified="2013-12-11" version="1">MSTTTSPTPSTSANIIYRRYDPKQEVIQLEAIRNMIGTDLSEPYSIYVYRYFLYQWGDLCYMAYDGDLLVGVVVGKLENHRGGPILRGYIAMLAVKESYRGHGIATKLVQSSISAMKALNADEVALETETSNKAALKLYERLGFLRSKRLHRYYFNGNSAFRLILYLKEAPNGGCCGEEGEHHHDHGEERGEREFDDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCE2</accession>
    <name>U4LCE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Probable eukaryotic translation initiation factor 2 subunit beta acc. no. P56329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_05604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCE2"/>
    <dbReference type="STRING" id="1076935.U4LCE2"/>
    <dbReference type="eggNOG" id="KOG2768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="149"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX29533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="281" mass="30986" checksum="4AB100F3980968CB" modified="2013-12-11" version="1">MAETEELVILPSAPKKAVTFDDEENVDATNTQEAAADEGDGLLDLKKKKKKSSAAVGSDGLLDLKKKKKKKVEAKAEDESTEDKKADGDAPSEEVAATSSEVQFDADELANGTGVWNSAATSDLTYPLLLSRFFTLLKSQHPDLTGDGRRNYKIPPPQVMREGNKKSIFANISDICKRMKRSDEHVTAFLFAELGTSGSVDGAKRLVIRGKFQQKQLENVLRRYILEYVTCRTCKSPDTDLKKGENRLFFVTCNSCGSRRSVAAIKTGFQATVGKRRRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCS4</accession>
    <name>U4LCS4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCS4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="284" mass="33065" checksum="D837BDCCEAD6AB3E" modified="2013-12-11" version="1">MLPPDRRIRCIRSADMTACARYGLGQDVIQVSSFCGFFGRVNMLTGRNTLSIPVAGIWESRIEKVSTYRQRVQTEIKASGKEDDRTRQRRTGWKRNKSQHAWNLGPVGRIGTFYPSDTDWRYWSEQSAFFGYRRHWTPTNCMIRLTVMPDKLQTVRVVINSFDVPPQVHPPEFRRLKVTCRRMKYILGHQTPPGTLGMGWSAVNNQARNHSPEYLSWSAVKPELPSIIHRMVRKMNHQTKYIPIRISHCQRDGIYHSGRPDSMMPMLFTLIAAVFFRLLQQQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCU0</accession>
    <name>U4LCU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCU0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="432" mass="48345" checksum="9209DBE25AD23EAF" modified="2013-12-11" version="1">MGFDIFRVNETAAIANYKQCIKNYDYTRSIYDASEHLHDSPSPYRPIADIINDALLALNYLCLLWCLLTSYFSLIIFNPSLPGGSHRQTCRNYALHRRLQVFITIRDPAILHILLYLLVTMQLLISVFPYIPSSWGLAVLAELAGTAGGYYGQYSLYFHITTVVVCFSSTILHFPPPPVEGGSQISGRSKVNRRFGLLLLITLCSRFIDSAVLTITSFLSSHLLIDGNKGKWRTGCLEIFAGEMLPVRVDAIIDAAVLLLLVAVVGFVCVIYELAWVIAVSRARADQEMGKKEPEDDEEEALERARSRLTWVARVGLVGICVGTAMTTLLLVWKLDYMRGYAQLVRNLEVCEGLRWRTAEGLAAGREVARNGITEGMNERIKVGIKVGIKGRGKWMVSAVADCVIWVGLTGVMAIEILAKYYRRKSMRKSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD67</accession>
    <name>U4LD67_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD67"/>
    <dbReference type="STRING" id="1076935.U4LD67"/>
    <dbReference type="OMA" id="WSISRRD"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651353" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="12765" checksum="BC933512B06A53DF" modified="2013-12-11" version="1">MQLLTLLPLFASLALGAPAVSETLSSITSATLGGVRYCNNVGYKGPCEGGVYSRNLCYDVTPEFNDRISAFSVDQGTSCTVYQDYRCKGNKRTIGFPGNGDLRNIGFNDIISSFICTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDC4</accession>
    <name>U4LDC4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDC4"/>
    <dbReference type="STRING" id="1076935.U4LDC4"/>
    <dbReference type="eggNOG" id="ENOG502SFI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14424" checksum="2EDBEDD7F57B6D5E" modified="2013-12-11" version="1">MPAQSIPSSSLPKFRAPPKTPMYLIGVRSNVGVRSQHGTRFVPNINTNAQPTQKTPQTQQTSQAQIPKAPKYIPRPLSPKELPAQYKGAERKIRTAIVALPIAIVTSYVLYQRIFKGEERKKFSDAVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDR4</accession>
    <name>U4LDR4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDR4"/>
    <dbReference type="STRING" id="1076935.U4LDR4"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DVGCGWL"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651279" description="Amine oxidase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="521"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="521" mass="58843" checksum="97EB84CD9039164C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE37</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30138.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="223" mass="25595" checksum="49A4C4F02A79432B" modified="2013-12-11" version="1">MSLQEEQVGQAESRKEQVESLQDPVESSEYCEPEVLLQQEELSELEEPEDSSESEESSDSDAGLEVEALVPGFAALTLENTEDAEESSDTEDTEEIEDAEDPDADTEELKDSEDPDVPPASPLIVPDFSTEEEFHRWLWEKMNTSFNQSDWPSVSIKSRQWLYNKMILDLPVFGNTNFQDYWETTRRFVWSHFRATQSRSKGKCCGMHDHSRMGPQMDDDHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LER7</accession>
    <name>U4LER7_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_08545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="11851" checksum="AD245EA5E401F0DA" modified="2013-12-11" version="1">MSFSFNPTNPQQTTSSISRISNTQQTMTPIPRTTTASSDSSDTSGWVVLSQSSLPVRQTEDSTPRTITAEIHNDVKEILQRLQRRQKEGEEAIAEYYSKGSGEKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF27</accession>
    <name>U4LF27_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 acc. no. Q9JKL4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LF27"/>
    <dbReference type="eggNOG" id="ENOG502S704">
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    </dbReference>
    <dbReference type="OMA" id="MDTTHAA"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="24455" checksum="3E1B14B1EF0098D2" modified="2013-12-11" version="1">MLPLTRGLLRALPRATPLRIAPALTRAFHLTPPITRQVSVAASTEEMQAAKESRVTDPDIPTLDIISNLNVYSDIPAPASAIDTIYDDGFTFTSGLTFTDGSGCILIHNEAFKWRPTVKGDEIEAKAMKTGILELGKEVWGLLDVVTPKPELLIVGTGKRTLMLSKEDRERITELGIRMDVMDTTHAAAQYNLLATERPNGQVAAALLVDAFAEVKKKKGGFGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFK8</accession>
    <name>U4LFK8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_08434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFK8"/>
    <dbReference type="STRING" id="1076935.U4LFK8"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="184"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX30292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="257" mass="28127" checksum="2D47AA894B085B44" modified="2013-12-11" version="1">MPVGINQPSNQIRLTNVAIVRLKKGKKRFEIACYKNKVLEYRSGVENDLDEVLQTDQVFINVSKGALAPKADLQKAFGANATTPDIVKEILLKGELQVGEKERSAKLDQMHAEVISIVASKCVDPGSKRVYTSTMIEKALGELATTQDGGWHGVKDGKSAKAQALEAIKALVAAQIIPIARARMRLRITGNKKCKEKCIELIEQVEEEEFINGGDWECTGFVEPGKYKALVDIVGAETKGRGRVEILDTAVIHEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFR0</accession>
    <name>U4LFR0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFR0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10558" checksum="7C2BD2E38BB6EB4B" modified="2013-12-11" version="1">MYYCFCMPSLLSLGRGLGYWRSVSIADTTLNCITRNGRTCLESHIHVFGDGGGVGKAAVVSITHFPSARQGFSMETVIPRRLFSFFSQGLLKSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFT7</accession>
    <name>U4LFT7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Protein FMP32, mitochondrial acc. no. P43557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_08586</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFT7"/>
    <dbReference type="STRING" id="1076935.U4LFT7"/>
    <dbReference type="eggNOG" id="KOG3156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAYMRFR"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="26818" checksum="E2056F3F97D90035" modified="2013-12-11" version="1">MNTRQPLLRLATCNTSTTLGLSSRLLTPSQLLLRPALLAIPPAHSNAFHSTPIRRRDHHFDTLKFVERLKAEGFSEEQSEALMRLLGDVIEESIQNLTRTMVPREDQEKINYTQKVDFAKLRSELTTLHGNELNPIKNDQERLASEISRLNARLREEVQRAQSSVKLDLNLEKGRIREESSVHELKIKETDTRIEKEVGDLRGMLESVKFSTLQWLIGVCTGTAALILGVWRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGB3</accession>
    <name>U4LGB3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGB3"/>
    <dbReference type="STRING" id="1076935.U4LGB3"/>
    <dbReference type="eggNOG" id="ENOG502QUAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EANIRYT"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="66"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="385" mass="43263" checksum="3E721CFDD4428D96" modified="2013-12-11" version="1">MANTQSTQRRTTPETNPISAGYHNAIPEATTHEPPSYEGSELPPARFKVLPREEEGRETLPQYSCTIHHEAVLERKMELRTPFDRAHRRNWKKVYLVLKGTKLEIHKPKKVPFAKGSLKGDNSMPIGYIPGTLLESYTLQLAQTPLRNSPPRVQTQQFLLSCRTLEIFLDWLELLSAAVDLAPPLEQRTLPRYQTLPRRRRRAQPPQTTLTATTTASAFTPEIIAAQQEIMRQQFPHLLSDPGAANRDSDRDRDAIEPIVSITPTRSSRSTAPVEFVPEGAKWSPRRGLTREANLRLARRCVAELMADAPRISDFVVMDGKRYKILWEQRRIVPEDGEWADVLMGGCSGTKGVKKGLGATGVMEPPGYAEVFGGLSMEAGGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGU3</accession>
    <name>U4LGU3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX15506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="167" mass="18734" checksum="3F1D212863A7BDB4" modified="2013-12-11" version="1">MMEEPAFLRRMRAAASGQGQPERYIAPRNRKVAVEDGEDAPAYVMEDGSSLSREEFQKLGGKGDDDEEEEEEGEKKDEDKKEGEAIEGEVKKDEEGKKMEEKVEDEDTKITVVEAGMKKKRKAAKIVGADDESEDEKTKKLEKAPAKDAKGKPKPKRRVKLSFGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Similar to protein kinase subdomain-containing protein [Arthroderma gypseum CBS 118893] acc. no. XP_003173346</fullName>
        </submittedName>
    </protein>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4231">
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    </dbReference>
    <dbReference type="OMA" id="SEVYCAQ"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="122"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="307" mass="34294" checksum="80BCE0367DF48696" modified="2013-12-11" version="1">MEHEYRNRPGVYFRLNVDQGLLGITLDEFKKLAEVQVHTKQYLESVRVDQLMEQLVDVLVGTTAPAESRVLSEVYCAQISDNPSPTKHWIVPSLKSTAFTERCDIISRMEKYILAKNTPGISMRLVLVLHGLGGSGNIERSQHVGKHKLRSIFAIFIEQKFSGVFWVDVSSTGSAESSFRRIAESFGLEQKSPEAVQLHLSHLDGWLLVMDNADDLDHNIAQYFPSGNRGALIITSRSHDTCQLSLKTTTGAAEYEIEKMETEEALSLLQKVSGQDVSDKDVYKDASTLVNELGYLALAIDQARSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHZ5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHZ5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3658" checksum="3480E005197298AD" modified="2013-12-11" version="1">MESPYSSTNYLHQITGPPFKVSSTTFTRNHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI52</accession>
    <name>U4LI52_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935669">
        <property type="protein sequence ID" value="CCX12004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI52"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5259" checksum="D163BDA966323E4E" modified="2013-12-11" version="1">MIEALVLLDTKLPETIHNCTDRPQRGRNIPKATFSYNSTDKELSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI87</accession>
    <name>U4LI87_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Cutinase transcription factor 1 alpha acc. no. P52958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX16406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LI87"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="VYWEMPR"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
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        </location>
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        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX16406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="910" mass="101812" checksum="218845D8153A3A5E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIC3</accession>
    <name>U4LIC3_PYROM</name>
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        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
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        <name evidence="16" type="ORF">PCON_03112</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
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        </reaction>
    </comment>
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        <cofactor evidence="11">
            <name>Mg(2+)</name>
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        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0456">Lyase</keyword>
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    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
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        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
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        <location>
            <begin position="209"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="409"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="576" mass="63437" checksum="7542393105A4E76D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ63</accession>
    <name>U4LJ63_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12065</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5376955at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="222" mass="24461" checksum="8344A4F740E3C172" modified="2013-12-11" version="1">MWYPKSLVTAEVKLEIITSFSKDKYFFTVTEREIPGEETDSDTEEVLPSETRPNGKVHRNATDPSAIPLKQSGLNALQVPTVNGQRPENINLRPENRPTSSPSTSPTTSNVDEDGRPKDLCTGCEKSLKGTTAYRCTFPVCQSMVCESCSSILSRHPQDGGAWGDIHELKVLLGLTPATETSGIVQPLQKKSPASGAAMMLKIQAKRDEEEEFKGRWGCYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ98</accession>
    <name>U4LJ98_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Cell wall mannoprotein PIR3 acc. no. A6ZZG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ98"/>
    <dbReference type="STRING" id="1076935.U4LJ98"/>
    <dbReference type="eggNOG" id="ENOG502STWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="46603" checksum="E9E13B7B47093686" modified="2013-12-11" version="1">MEASGAEEVVNLTVDAPVDDVVIENSGVEEVSPVIGYHSTEELVQEQFPTMTDEEAINYVEKEEINHADNQAGGLDIEATLARAEAEYLEEKAMEDPSPEHTKEAVDAEVRAAELYLEAKKAYDVADEKKAIYDEKHPGERAAEFAAYIDDIAAHATVSEENVIEVDDSEDVAEAVIADVPVEEAAVDTVVDEATASGDLVARNLPAVSQIYDGQIQIVPGGIPPITQIIDGQIQIVPGGIPAVSQIYDGQVQINPGLPPVNQIYEGQIQINDGQIQIVPGGIPPVTQIIDGQIQIVPGVIPPGQIQIGIPPVTQINDGQIQIVPGVIPPVSQIIDGQIQIVPGVIPPVTQIVDGQVQINPGLPPVSQIYDGQIQIGIPPVNQIHDGQIQIAVQKREESGKPMVVEHCHVTAGSSRLQIVSFAWIGAVLVLGVALMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJI6</accession>
    <name>U4LJI6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Ferredoxin--NADP reductase acc. no. Q98M06</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJI6"/>
    <dbReference type="STRING" id="1076935.U4LJI6"/>
    <dbReference type="eggNOG" id="ENOG502QQ27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGPSWMI"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="505" mass="56005" checksum="BF7D928006F84A72" modified="2013-12-11" version="1">MVSEDINVDVLVIGAGPTGLGAAKRLNQFNATSWLLVDANDVPGGLASTDVTPEGFLYDVGGHVIFSHYRYFDECLNQALPNESDWYTHQRISYVRCKDNWVPYPFQNNISMLPKEDQVNCMDGMIDAYLEAKTATTKPQNFDEWIVRMMGNGIADLFMRPYNFKVWATPTTKMQCEWLGERVAAPDLKTVTKNVILNKTAGNWGPNATFRFPANGGTGGIWISVASTLPQEKLLLGEKGTVTGVDADAKTVTTKDGKKIKYNKLISTMAVDHLAAAMGDNELVELGKKLTFSSTHVVGVGIRGTRPENIGDKCWLYFPEDDCPFYRATIFSNYSPNNQPEAAIKLPTLQLADGSAPSNTSPQEGPYWSLMMEISESTEKPVNYDTLLQETIQGCVNTTLLSADAEIVSVYHRRFDHGYPTPSLARDGVLKELLPKLEAKNILSRGRFGSWKYEVGNQDHSFMLGVEAVDHVLKGDEELTLHKPDYVNSRPNVERTLGEVLEAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJY4</accession>
    <name>U4LJY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJY4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8370" checksum="25ACCC5149BA52AD" modified="2013-12-11" version="1">MTFVMIHPGTQKFKNPPASTDKNPQSGTIPSSASSSESSAVPRSESQSGTQKTELSYLEILAAEQKAREARRNSPDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKK3</accession>
    <name>U4LKK3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKK3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12506" checksum="AF6CF7B4FAFFAE66" modified="2013-12-11" version="1">MENNTSPSPAPHSPKSISNRALVKLQLRDLGLIAPQISDANIAIFEDRKVHDGKLFVSMVPDGNMQMLISQPNLGELNGKPNGELNTKPEPQAEPEPKKWHAKNQLVAVKSHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL16</accession>
    <name>U4LL16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL16"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="33" mass="3636" checksum="FC10CB02DC38F7C2" modified="2013-12-11" version="1">MLSTLHRMHHRGSKKKGLAKILLPVSESPNLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL30</accession>
    <name>U4LL30_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL30"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6502" checksum="1E4CE72E6D92776E" modified="2013-12-11" version="1">MAHHLLNSLCIPTSMRSLDSAGVDPADEFQLSAVPEGGAEDTRFRVVTNKTRVISGSLCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMX8</accession>
    <name>U4LMX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="8" mass="942" checksum="EE776326C1A72336" modified="2013-12-11" version="1">MKLTQKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN07</accession>
    <name>U4LN07_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN07"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8279" checksum="9152A63F52AEB91B" modified="2013-12-11" version="1">MRKTVLQWIAMAERPLTVEEMQYTIATEEGVPFDPNSIILPQKDDILKCCDSFVGIYNNEDSETLEFTHLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNL9</accession>
    <name>U4LNL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized transporter C1002.16c acc. no. Q9US44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNL9"/>
    <dbReference type="STRING" id="1076935.U4LNL9"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYITLWY"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="500" mass="55587" checksum="6BCB61F7213D443F" modified="2013-12-11" version="1">MTTKDYNSSSEKVEVEHVSAPGSIEHGSIFDEAATKKLLRRLDWHLVPFLSLLYLLSFLDRTNIGNARLAGLEEDLGMTGLQYNVALAVFFPWYVIAEVPSNIMMKRTSPSKWLCIIMVAWGLCMTLMGLVTNYGGLLATRMVLGLAEGGLFPGVTFYITLWYRRHECGLRMAIFFSAATLAGAFGGLLARGIAEMDGVGGKPGWAWIFILEGILTLIVAVIAYWAINDYPATAKFLSTPEKVEVERRLKEDRTSLADEYHTKYFYQAMKDWKIYVHMMITIGSPLESGIYTPLYSVSLFLPTIVKGMGYTNENSQLMSVPPYVAACACTIATGYFADRQKQRGLYMIGCCIVAMTGFAMLLGTVNPHVQYFGVFLTACGIYPCVPMGVAWNGNNIGGSTKRAVGIAMHVGFGNMGGLIAAFSYRKTDAPRYFAGHGMLMGLIMMSCLLSVFMHIYLKAENVRRDRLMAERGLTLDTYTEEMRESERECGDDATFFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP55</accession>
    <name>U4LP55_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP55"/>
    <dbReference type="OrthoDB" id="10313925at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="233" mass="26618" checksum="5BE0B7BB2922137D" modified="2013-12-11" version="1">MTVQKTFTYNPSFPMDYQEYYLSTFSFLRDDPNLLGVYCPTKPSTVEVTRDPYTSATITVRGVSDDSYDYPRPWDTGYCPGTGQGHELRGSECRYCSFDCHNDSCPMTGRNHYMIGDYCHDCVFYSKPIYNLLASYKPNGTPNMGWEVFNAPTYRKTQPKGLSEKVMKAWKEIDERDYRVPTLKGNPKILVLWLASGWNNALVRFADSNVQKIAALLRDPRSLADIAVITNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPB0</accession>
    <name>U4LPB0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein phosphatase 2C homolog 1 acc. no. P40371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935546">
        <property type="protein sequence ID" value="CCX31165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPB0"/>
    <dbReference type="STRING" id="1076935.U4LPB0"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="PP2C"/>
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    </dbReference>
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        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2C-like"/>
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        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="128"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="446"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX31165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="526" mass="56586" checksum="96DDB7AA086051FD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPG6</accession>
    <name>U4LPG6_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_02539</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
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            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9129" checksum="9960D64A96A2CE17" modified="2013-12-11" version="1">MGCSMRCLGCRDFFMRCSLYSSFASIYHCHPFHSSFDEVELKQRGAHPTEIEGFAWPASGSEHNSAQATWVQNDYCTKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ27</accession>
    <name>U4LQ27_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_04051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="337" mass="38605" checksum="D1F72B35A123D571" modified="2013-12-11" version="1">MPNTESNYAKQFFDTLKSDTITKFNRRLEKLNIWSTNMPVEILGIVTLAVTVITTAVTYADKVSSAPDEQNLAKILIDTIDDMRTEVIDLRSKYGSRLSPAQITRIDNTIKNTGDLVSATRKLLAKAAEPPMGEFIGGVMWVFKDKGRVESQKEVLLFLHGSLNVIHGELRALRCTECDDTPPRYDEIYSANNKEMLMMGLRKLAAAKVRYNQEMYNQEYNQAVVPEDLGRRLSEDLQNYISWSEESKSNMAREALRRRTESMEAKKMAMAEEPEARPTSPTTQDNLAKEARRRYREHIMLSKNPEPPVRMVSNRTRNNMQAEARRQFANRARMAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQX1</accession>
    <name>U4LQX1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to High-affinity glucose transporter acc. no. P49374</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQX1"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VFFMYPE"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF54">
        <property type="entry name" value="GLUCOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX31730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="56131" checksum="B98579B4891E4A12" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQY4</accession>
    <name>U4LQY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936516">
        <property type="protein sequence ID" value="CCX34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQY4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14417" checksum="F2D2D7449AE0A24F" modified="2013-12-11" version="1">MKLAVQVTTSHRDTGASFDVFLLSPAWPHVSIERCTFFIAAPANSASPRRIPFHRLFTVLAGRFAYHDFFISQTMKNFRKHRRKTAVADADACPDAYGLQFVLPQGRTSAALNVAMLPHTIVPLIRGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRB9</accession>
    <name>U4LRB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRB9"/>
    <dbReference type="STRING" id="1076935.U4LRB9"/>
    <dbReference type="eggNOG" id="ENOG502R6QX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3945378at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="496" mass="54627" checksum="B3D942EBCAFA297E" modified="2013-12-11" version="1">MPGAIRIPPMMPMIFPKPPMKNAAVILLAATLLYVNLALALPTSPPQQTPRILPRQSPPRNANPTLCTFDGDQDMYGLGIRIGYYIQWVATVFGAYFTPKVVSSAFEANALFNIGMLAGLVYSTIARNDMHVLEPIIVLGFSIGGAIVGLLDPKNVHHPKDLKSLRRRLVHLAATGALYLPLLTYWVWFSFHGMDTLRTEGDACVPYTFLLAKIDARAAWFRTFMKVTTVISIVAICALGGFLAVTYRAKSHILPENPAPRLSRTTTALALRARPTKLQFGIVIFACLICALSVELPILWNNIGGVNGLGATGQLIPMAIGLLTSIRVVVGIVGLQFRTRKQRRKEFAKERMFGRRQQEMQRRDLEDDGDTDGNTDGDGMTISRTTSKAATVRTFVTADEQGEITEPEQKRRKLKRKRTEEKGEKVAGFYIREVEAGASTSATRATSVRTRRDGESSEDMEPTSTDSPTTESPTRPTPPSRQGPGVLRKEQSGKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRC3</accession>
    <name>U4LRC3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_02624</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRC3"/>
    <dbReference type="STRING" id="1076935.U4LRC3"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="117"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="934"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="520"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="595"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="875"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="984" mass="108253" checksum="1CEDCBBAE0F4AF92" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRP6</accession>
    <name>U4LRP6_PYROM</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_04349</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34831.1"/>
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    </dbReference>
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            <begin position="22"/>
            <end position="44"/>
        </location>
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        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="24503" checksum="E8E65C5F0A0C19D5" modified="2013-12-11" version="1">MGFKRTDKPLISSYLWKLKYESRSTNPSDPNDNHGTLHRSRERSIPMKINIPVLEGIAPSRIPMLSEFGPRANRQVLKFRNLYQDLSKSVRNFNHLKHRQEVLYRMPQLGPAFMERMQKMARLIPAGGPKATKRRLRGRGLKHSTRKHGAPCQPSPLRNVMSMEDVLEMEKILDRDVDEGYHDNEVDKSKEAKNVDTATRKSPVMDIKFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSB2</accession>
    <name>U4LSB2_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502RZZS">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="506" mass="55167" checksum="D9EE982D6D34F1D3" modified="2013-12-11" version="1">MLAATPLYVTLLPPQILLPHIKHHPITVVPCDRSHPFVRLSTTSQASFAPSNIVIINSGTSTWHHKNANKELSYNAVPTPQSASTNSTIEVERRFLEHYPTIQLHRRSYSYIPRTSHLEQQQPDPKNPTNRSHDTPPSPRPPPPPLLSLLPASLTPTLPTALLPLLTPILRNRLKLLSTPSDPWALLLSWNSTHATHLLQHLSTLDLCSPASGILLGLSRLDPETLKAAIEVPDLGLVVIYIWSPNDPDGEDDAWRVLDVLCAEDVEGEWYPTVEVAEAKFSASQTSGGRTLAPVGVSISPPSGGEQDAEGDEEDDYWAQYDRSSAATPAARELDNPPTEDDYFKQYEDVTPALDGPSAYGPTSAPELHNYAESVAASTYPEPSQTIYSGSPRQSDAHSETHSEVARRFSMGTATSTSTPPTTYSAPRAISPSLSATASGMGSEVVRKMEESAGLQTQMETAVKQHVATSVKSMYRLAKVSGMGREEFMELVKTELEVLGMMDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LST2</accession>
    <name>U4LST2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to UPF0674 endoplasmic reticulum membrane protein C2G5.01 acc. no. O94280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LST2"/>
    <dbReference type="STRING" id="1076935.U4LST2"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FDGFVWA"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="431" mass="48396" checksum="F0ADF0BDFF031CE1" modified="2013-12-11" version="1">MADLIGKVFKAASASAAAVTDDDFADFASTSPAIAAPAAESAATISPLSFASSTPLGAPAGFDGPWYAVWERHSLSEFQTEGYIILLIMFIVGIHMWGARRNRSIAAGFIAAIAPILTKEFALVGFSEEGKPNTLDEKNILDANAAIQENTQMEFISYASGRQNIQFMHTTIKLQRRHNPVAWMAEIIFAFFFDAMPQPTDSITMTIAPFDGAEPPKAVSGSSKYDNFIWAVVNKRCMKKHREERYDLSLTRTSDWEGLPNWAAVMGESKEIGDMCLYQQLKDVIPECGDFLEYLIVSDMPKEKPSKLADYTPRKRITLELTIPSAATNPETLQRLVGAFIRLVDHLVANAHFRPEVLRKVKATREDEQKKLKRSIEDETKEERETKLAEKKKADRDAKLRGMSAAEQKKFLEKEREKERKDMMKKMGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT10</accession>
    <name>U4LT10_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT10"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3476" checksum="C29AB4FAB1D75864" modified="2013-12-11" version="1">MYPQLGSTLDPGTGYGYSMTTYYRLSPLGAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT74</accession>
    <name>U4LT74_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT74"/>
    <dbReference type="OrthoDB" id="2563155at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="129"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="30157" checksum="B54906CDD24792AF" modified="2013-12-11" version="1">MSLTTITLRNGNILEPSDEILPGKLAVYELLDDTENRIFTGTFYLITDSPEHGDNYVVTHEGGNAWLRRAELDGSSEVIVGNLDRTHLPQLPLPGTVDRYLVPEIIDAVPDEEQDGDKREERDINTAIHGPYDTHTLQPSPLSAGNLPASAAAGADDDVPVDIPRSADPFLAASPSAEPDGLYATHEQHAPETPRPDNFVDDVPEYLLTTNKTPTRSREDVSASYADVGLDESVCSGYSAPESEDDGDESDRWSVLSTGPVDRQWTVVYEEKDEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTK9</accession>
    <name>U4LTK9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10411571at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651766" evidence="2">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12400" checksum="6BB40AEE5D92F270" modified="2013-12-11" version="1">MRPILYSSLIFAFWSKVCVIGCSDDFVSRPFDYDLIINCENIEQCSAIDMVYFDSVSIVPTSSLVCDNGFQSISEQFVGNNTGSNPPGSTVDDKSASPSPSEGQKKNAGVINVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTM2</accession>
    <name>U4LTM2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTM2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="10699" checksum="7424EBA4D0575823" modified="2013-12-11" version="1">MSFLYTSITICCLSSNIANSLLHFSRRFAFSSSSSLVSKYDQKSMFPLDILKSCVQSSLGLVPSGASSRLDLSCLPNSSKDEAEVSAMKSIREVAFVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTR5</accession>
    <name>U4LTR5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Chromosome-associated kinesin KIF4B acc. no. Q2VIQ3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_14079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LTR5"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEQHETL"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="52"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="840"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1537"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1642"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="937"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="982"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1543"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1567"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1642"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1677"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1708" mass="190738" checksum="822CB60EDE758A01" modified="2013-12-11" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU77</accession>
    <name>U4LU77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized membrane protein YDR090C acc. no. Q03193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU77"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCISRAT"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="286" mass="32089" checksum="BE2BDB1FC9B670A9" modified="2013-12-11" version="1">MVVQEQTHIPLPATVLGAVGTVCWCVQLVPQIYHNYKRKSTNGFPASMMLLWALSGIPFGVYGILQNFNMPLQIQPQIFMALCMIAFGQCLYYSHHHRLLTAYFFAITLLIMFVATEVLLIILFRPIYRAGNVTPLLAIGTIGSILLALGLIPPYWEMFKRGGMVAGINFLFLATDAAGAFFSLMSLLAQPSFDKVAAAMYCVLLGLEMGIFFGHGLWWCLKGRKLSPEEIRALERFGEKENKRKTRELYLEDGSDEEKDKENDSGSENGDDMEKNNGKKLWDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV19</accession>
    <name>U4LV19_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV19"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="8848" checksum="5B25A34550ED95FA" modified="2013-12-11" version="1">MMSINDKLNSALPQSATDRTPSTPHHLTNAGAQLQLLALLGEGIIRIARNHLCRHLLVQPIATDLPLHKPKPTKGNCCRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVH4</accession>
    <name>U4LVH4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to 40S ribosomal protein S28 acc. no. Q10421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVH4"/>
    <dbReference type="STRING" id="1076935.U4LVH4"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7738" checksum="6E26BBB70F4D213A" modified="2013-12-11" version="1">MESQKVAVKLVKVIKVLGRTGSRGGVTQVRVEFMDDTTRSIIRNVKGPVRENDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVX4</accession>
    <name>U4LVX4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVX4"/>
    <dbReference type="STRING" id="1076935.U4LVX4"/>
    <dbReference type="OMA" id="ERRYWER"/>
    <dbReference type="OrthoDB" id="2758145at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34409:SF1">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34409">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="628" mass="69693" checksum="BA4C8DFCFE727028" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVY6</accession>
    <name>U4LVY6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Eukaryotic translation initiation factor eIF-1 acc. no. P32911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVY6"/>
    <dbReference type="STRING" id="1076935.U4LVY6"/>
    <dbReference type="eggNOG" id="KOG1770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEFMITQ"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12964" checksum="31B6DE6D67296520" modified="2013-12-11" version="1">MSIENLKVNDPFADDVGDTQPKNYVHIRIQQRNGRKTLTTVQGLSKDFSPKALLKAFKKEYACNGTVIIDPDMGEVIQLQGDHRTKVMDFLTDKDKSKMGKYALQKDHIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW16</accession>
    <name>U4LW16_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_14092</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW16"/>
    <dbReference type="STRING" id="1076935.U4LW16"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPGIRNQ"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="429" mass="46391" checksum="89982F936901BE30" modified="2013-12-11" version="1">MGQTLSEPVVEKLSESGGDDRLIYGLSSMQGWRISMEDAHAAILDLQNGDKEPKPTTRNERLSFFGVYDGHGGDKVAIFSGENVHKILAKQSAFAAGNFEQALKDGFLATDQAIRDDKRYEDEVSGCTASTALIAGKTIYVANAGDSRTVLGVKGRAKPLSFDHKPQNEGEKARITAAGGFVDFGRVNGNLALSRAIGDFEFKNIQLPPEQQIVTAYPDVVVHEISEDDEFLVVACDGIWDCQSSQAVVEFVRRGIAAKQPLEKICENMMDNCLASNSETGGVGCDNMTMLIVGFLAEGQTKEQWYDVIAKRVAEGDGPSEFRGPGKRGQFREQTPDEFDEDSSNGGSVYAAGGRGRVIQLGNGNQVVIHSEMEMFDDEQMKEDQDDEALPKTTKAAPPAQADSEMTDVTKPEPTTAAPAEKTDDKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXA0</accession>
    <name>U4LXA0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Nuclease PA3 acc. no. P24504</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936512">
        <property type="protein sequence ID" value="CCX34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXA0"/>
    <dbReference type="STRING" id="1076935.U4LXA0"/>
    <dbReference type="eggNOG" id="ENOG502RY0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WDTSIPN"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652016" evidence="9">
        <location>
            <begin position="19"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="35332" checksum="DCA44A9484335387" modified="2013-12-11" version="1">MKSTVILPLALLAGCANAWGTLGHQSIALLAQQYLLPGTIESVQTLLNDTTTTYLGNIALWADSFRYTPEGSFSGGYHFVNGHDAPPPESCEIIYPEDCPPEGCVIKAIGNYTERLKDHTLPVDQRQQALKFVVHFIGDISQPLHTEAFGAGANNLTVWFQGYKTNLHAAWDTAIPNAMIGFPPNAKIGNGDSLGWANNLAAAINAGKYKKLVWAWLKDHSLRNLKEEEKAATVWAQESNEEVCDYAMVKGGNAYNGTEIGGAYYEGAKPIVEVSIAKAGIRLAAWLNLIFEGQTGFEVWSIGQPGQGQGKGENKGNNNNKGEGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYL8</accession>
    <name>U4LYL8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYL8"/>
    <dbReference type="STRING" id="1076935.U4LYL8"/>
    <dbReference type="OrthoDB" id="5372266at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="289" mass="32563" checksum="9BEB18E1D00FB380" modified="2013-12-11" version="1">MACILDNTGATIPGVWLAAKEVTRARMNPVAAEQERFGNSHDLKLIFVEHIGYYLTMACIKAAYMLFYTGLYFRADCRRKIPLYIAWGIYAASYISGLFLLFFWCHPLSDNWHPTNPYCSSVFSLPIFTTLALLNIITDLAILLPLFTLLSSLRLQPLEKASLAVIMGIGSISIVASMVRLVVVGKRLKEKPQMDWDTARVCFLLCIAEILFAVVAFVGPSFRGVFIGWRKERSRRESKQEVIQEEFCDKRRFRVFEGCGSLSDEKGLRVGTPKSSGGETEDTEFSARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV18</accession>
    <name>U4KV18_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Meiotic recombination protein DLH1 acc. no. P50265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_03294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935214">
        <property type="protein sequence ID" value="CCX04691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV18"/>
    <dbReference type="STRING" id="1076935.U4KV18"/>
    <dbReference type="eggNOG" id="KOG1434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANPMKPV"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="97"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="283"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX04691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="334" mass="36213" checksum="9F78C9AC13DC216F" modified="2013-12-11" version="1">MTREDTVDFEGDDDETNGIVEIDQLQSHGIGASDINKLKAAGYWTIAAVCAATRRNLSKIKGFSEQKTEKVKEAAAKCAPPSYNFVTAAELGHIRRKVCRISTGSKSFDAMLGGGVQTMSITEVFGEFRTGKSQLCMTASVICQLPKDQGGAEGKVAYIDTEGTFRPERIKQIAEKFGVDGDMACENIIYGRALNSEHQLELLNGLCQSFATNEYRLLIVDSIMACFRVDFCGRGELSERQQKLGQMLAKLSHMAEEFNVAVLMTNQVQSDPGASALFASADGHVLAHASATRILLRKGRGEERVAKLQDSPDCPEREATYIITNGGIADPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVP1</accession>
    <name>U4KVP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVP1"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFRDVMA"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="257" mass="28955" checksum="594CBAAF87576B8C" modified="2013-12-11" version="1">MSNPPPIIRLVAPSLTTYSLPFLRFNRIKFGGRATVIRLSSGSLAIFSPIPLTADVRASIASLGGTVRYLIAPDMEHHMQLGPYKTAYPQALVMAPEGLAAKRRKQGDQEVPIDYEFTAANKRSIKLPEEFAQDLEVEYWDGHASKEITLLHKPSKTLIEADLLFNLPATEQYSNAKESATSGIWTKISTAFMNTKPGSKGQQRFMWYVLCRDKASWAESARRVQQWDFDRIIPCHGDVIETGGKDVFRRLFAWHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVP8</accession>
    <name>U4KVP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Demethylmenaquinone methyltransferase acc. no. Q9RRT0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVP8"/>
    <dbReference type="STRING" id="1076935.U4KVP8"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEIRTHF"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="327" mass="37507" checksum="203B366DDD21318F" modified="2013-12-11" version="1">MQFEETIEVDPSVLEKPENEDYTSSGYDTSTKSLTSSYNEYIVENGRRYHSYYGTEKYLMPTDEKEQERLDLQHAIFRLVWNDKLHEAPLTEPHRILDIGTGTGIWAIEMAEKYPMAEVIGTDISPIQPCWVPPNCRFEIDDAMQDWTFRDNFFDFIHARTFSSGVSDWEHLISEMKRCTVPGGYVELCEQSLVTDCDDGTMKPDHGIKVFTEHMRDAMRKMGRPWPDLAFLKNLLENAGFEGVTAAVAKEPMGPWAKDPRLKRVGSMSLLNGETAFESYGMALFTRILGMDVEKARKICENGLLAARNKNYHVYDPSIRVYGRKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWX8</accession>
    <name>U4KWX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWX8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="24" mass="2708" checksum="69042A13CE6332A6" modified="2013-12-11" version="1">MPYLDIPFRLTRSSYLGGLGPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX50</accession>
    <name>U4KX50_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_05923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX50"/>
    <dbReference type="STRING" id="1076935.U4KX50"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX06336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="454" mass="48204" checksum="D39F0B4EA570A51F" modified="2013-12-11" version="1">MASRLAVRRLPTTRCLCSSAPTVARTSTRAFSNVSRAPSNTLLSAVARKPTSRFVKAASILNVQTRSYADTVVKVPSMAESISEGTLKQFSKQVGDFVEQDEEIATIETDKIDVAVNAPIAGTITELLVAEEDTVVVGQDLLKIAPGSAPEGGAAPKAEAAKEEPKAAADVKTEAPKQEAPAPKKEEAKAPAPAPKAAEKKPAAASPAPAAAPSAFGNREERRVKMNRMRLRIAERLKESQNTAASLTTFNEIDMSALMEMRKLYKDAVLEKTGVKLGFMSAFSKAAIEAMKDVPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPIVRNAESLDMVGIESAIAGLGKKARDGKLTIEDMAGGTFTISNGGVFGSLFGTPIINLPQTAVLGLHSIKEKPVAINGKVEIRPIMVVALTYDHRLLDGKEAVTFLVKIKNYIEDPRRLLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXP0</accession>
    <name>U4KXP0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXP0"/>
    <dbReference type="STRING" id="1076935.U4KXP0"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="233" mass="26064" checksum="D88D96A92E3F1E78" modified="2013-12-11" version="1">MRLKLTIPTRSLLRHTPQTRAISHLHFHRSSLSITNLQAVTASITNTIPITTTTTTRLFSTTTPTNMSSDADYMAFLQKQQQRAEALAATTTIGDLGEKEVKVLGTGEEPHSAIRNLLNTDVEKSYYSSGLEIEEFKDITLEWGKEEMPTEDEFATLLSTGPVTKEPFSSWDPRGNYKETEIAIKKASGADEVSVYRVSREGARYEYFVLAKVVKSPRLVGVRFKAIEDVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXX7</accession>
    <name>U4KXX7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to DNA repair protein XRCC2 acc. no. Q9CX47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXX7"/>
    <dbReference type="STRING" id="1076935.U4KXX7"/>
    <dbReference type="eggNOG" id="KOG2859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TAFFWQD"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="42159" checksum="F15F51AD654FEBB3" modified="2013-12-11" version="1">MAGETGSIAAMLLAELEVEHLSETYLGELCWENHNHLLRIPVLDAIIGKALNTMPIPVEMDIDERPPLANSTRFGTVIEISSVHTSAGKTHLLYYITAMCVLPETSCSIQLHGRSSSIIIIDNDGRFDVSRLFTIMLSHVLSCYKESGLDIPDSGAEAVVKDSLQHVHLFRPQNLAEVVKVLQGLPDYYTSPRYGTLDRSLGGILIDSLSAFYWPEKLANSVSEGSDTGSHETYETMVRLIRGLSDRFGTFTIATTWGLHLVDETHQAPTTFGHATKSSTETPVFYPYFPSVWNRLVDVKLVVARNVKPRFSRNTSISEAFQEIRLHNKASARYAFKGWIDIRGLSPAAQEYFSTNEGTFRFNIMPDGIELEEQSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY16</accession>
    <name>U4KY16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY16"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651725" evidence="3">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="7289" checksum="B977D87518C05E05" modified="2013-12-11" version="1">MKFPFALLFTSAFVGTALATLNPDPKKGKHGSGSDDNTSSSSSSSSFAMEAGSLAMFGAAGTAVTMVAMMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY75</accession>
    <name>U4KY75_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY75"/>
    <dbReference type="STRING" id="1076935.U4KY75"/>
    <dbReference type="eggNOG" id="KOG3985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="307" mass="33073" checksum="2E3B29BA554F9925" modified="2013-12-11" version="1">MSALPTTFSEPVHIAVIGGTGIESLVHDGFVPAAVLTPTTPWGAPSSPINILRTATGVPIAFLSRHGVHHELTPSEVPNLANISALRAIGVRTVLAFSAVGSLQEDIRPRDFVIPDQIIDRTKGIRPHTFFEKGIVGHVGFADPFDAGLTAIVAKTAEKLEGGAKLHVGGTVICMEGPAFSTRAESKMYRSWGGSVINMSALPESKLAREAEMAYVMVCMSTDYDCWKTDEPPVDVAVVMGNMKQNGENAKRVMVAVLEELALEQHEDLVKGRHLEGASKWANCTKPEGVTADARQRIEFLFPGYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY98</accession>
    <name>U4KY98_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to putative reverse transcriptase [Phanerochaete chrysosporium] acc. no. AAX11377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935339">
        <property type="protein sequence ID" value="CCX07187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY98"/>
    <dbReference type="STRING" id="1076935.U4KY98"/>
    <dbReference type="OrthoDB" id="3599942at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="415" mass="47284" checksum="4CCABB2363825EBD" modified="2013-12-11" version="1">MKDYQRAKGNRRTNKSFFLEVLIGRSAVQTVGPSPPKELFVLEGIELKSEFRDLLSRGARYLSKHGCSLYIDPDNLDESVAHLPRLLDTFGDFCRKLAWKLVPRDEHEEKYNSKLRTGPTGKWPTELPHWFKVGCDKGWSMLKEETHKALVESRTTKKPGLRLADFVDLACYLADKKLLVLATDKNLGLSVVTKEWYLNKITTLFDDPKTYKVLTGGPQTLVNRVKTFDETLARLCGKFGSTLTDQEVKYMREPIAFLRYENMEGVSDTDLSLRAIWVIPHAYGIPKVHKKPWQLRPIVPFTKWIGRGASKVLSLRLQPFLKRFPVILTQSRQLVYEHIDRSFQPPTGYKLFIATGDISGMYTNVNSSIAVNTIRAISGRFATKNDADLNTELFSLVNDRLPMRIQGKGGLPTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYP1</accession>
    <name>U4KYP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935312">
        <property type="protein sequence ID" value="CCX06775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYP1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="1939" checksum="C86EDBCB097395AF" modified="2013-12-11" version="1">MRISTAVTSSDLQLASRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZA5</accession>
    <name>U4KZA5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Translation factor GUF1, mitochondrial acc. no. C1GX39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZA5"/>
    <dbReference type="STRING" id="1076935.U4KZA5"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QVKCDEN"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="113"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="707" mass="78603" checksum="EA19C1FEDBCFEDFE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0A5</accession>
    <name>U4L0A5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_05011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0A5"/>
    <dbReference type="STRING" id="1076935.U4L0A5"/>
    <dbReference type="ESTHER" id="pyrom-u4l0a5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEWVYRN"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="489" mass="53822" checksum="0F2E7DABA87A3528" modified="2013-12-11" version="1">MPFHHASLNATVKPVSISSSPGILQYRNIKFASIPERLQHSQLINDWNGAEIGSDKHGPRCPQLHYDLNTLFRIPAEHLPNWKVDEDEFECLNLEITVPEGVKPGDNVPVMIWVHGGSLVATVGCAETKVCDPVKLVASSVEVGSPIIYVAINYRLNFLGFTYISEDLSNFGLFDQKKAIEWIHKHISGFGGDPNNLTLAGESAGAIATNFHTISNHSHLIKQVILQSGTATTIPPQPTAVGDFFRGKLFAQLVVSNVDDFRKLPVEEILAAQAAIGVHTLFPIATGTFWAPKTAPAWPGAVLIGDCEREHSLFTTGITSVSEPRSLFPQLPQSETILAAYGDDHMGILRFAGDAKFNYFTEMYARDFAKSSGGKAYRYIFDAANPFVPEAGAHHAVDLLYLFGGIPLPVEQEEVGAEMRSRWVKFVNGSAPFDSEKVLVFTSVKAEVMDKAEISKRRNVEQWKVLEELGWEKVAPVVGDVVRGRIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0L3</accession>
    <name>U4L0L3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Alpha-ketoglutarate-dependent sulfonate dioxygenase acc. no. Q12358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_08398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935432">
        <property type="protein sequence ID" value="CCX08805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0L3"/>
    <dbReference type="STRING" id="1076935.U4L0L3"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHFGKPN"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF30">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_7G06030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="90"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX08805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="373" mass="42241" checksum="740383E1A9A37FD2" modified="2013-12-11" version="1">MAPHVEAEAPPSPALTSTDSCSDDDEVYDINVPIRAGNKPLRKSSTPYPQYLPTWDPVFFDALPEFKFVDPALRADPLKRALLTPGVTMAPISPKMGTELTGVQLSSLTDMQRDELALLVSERKVVVLRDQDFADIGPFKQQDFANHFGKPNYQPVSGSVPGYPGFHIIYRDGNRKEIERYFEQKSSASIWHHDVSYERQPPGYVTLCMLQCPEVGGDTVVASMTEAYKRLSPGFRQMLDGLMAYHSSERICGFARSNGGLCRKDPVKSLHPLVRVHPVTGEKSLFVNDEWITGIQGWKKEETDWLIKYLMDHISKGHDFQVRLTWKPRTVVLFDNRSTCHTATVDYDGVYERERHMFRLAAMAEKPIPVHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0U9</accession>
    <name>U4L0U9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0U9"/>
    <dbReference type="eggNOG" id="ENOG502SARD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CIRFLQF"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16774" checksum="85C201503FF65067" modified="2013-12-11" version="1">MVLKSTSNRSAPPGGVVGLALRILLRVSQIIVAIVTAALYGKDVGAGNHAAAWVFAVVVSVLSALTAGVYLLPFLRSHKTFAWDAILFLFWTALFGAFANMYLHAVCKTGCRNMKTAMWFDLIGMLLWFISATAGAVMFWKERRRAYTGRGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1N0</accession>
    <name>U4L1N0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_05720</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1N0"/>
    <dbReference type="STRING" id="1076935.U4L1N0"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000141">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="14">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX06133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="363" mass="39363" checksum="F26E7F5D5261169A" modified="2013-12-11" version="1">MTAVAPPAAPPAAATARPWEANHNVQVMCPDCRETPANLVEEFSSGDMVCGSCGLVLGDRIVDTRSEWRTFSNDDQGNDDPSRVGDGANPFLNGSQLETSISYTPGGAGRDLHRAQSKATAQKNNNKTLLAAYKEIGAFCDSMGLLKNVSDSAKQLFKRVDDGKSLKGKPQEAIVAGCIFIACRQERVPRTFREIFALTKVPKKEIGRVFKQLEKIFHEQQRSEEAELIAKGGDPSIVQSASNLNSSYKTTSSTKAHDLMIRYCNNLHLSQQCTSIAQQLSNKAANLGTLAGRSPISSAAACIYLVSHLLKQPKSAKEISSVAGVSDGTIRNAYKHLYNDREKLIDKAWYENGKGDLSALPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1Q8</accession>
    <name>U4L1Q8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935416">
        <property type="protein sequence ID" value="CCX08479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1Q8"/>
    <dbReference type="OrthoDB" id="2559326at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX08479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11705" checksum="0E3B6FEDC6649D57" modified="2013-12-11" version="1">MNTLRAALRAANPGGPGPIDTPAQSPPRYTKAYGWGALIVAGGGAYYFAKREIDADRRQKHIDMVEKQRKQHLMEQAEFGNNPDRPRSKYEASVPYISPKGDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2E5</accession>
    <name>U4L2E5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Sphingoid long chain base kinase 4 acc. no. Q12246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935457">
        <property type="protein sequence ID" value="CCX09325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2E5"/>
    <dbReference type="STRING" id="1076935.U4L2E5"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMGNFYA"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="6">
        <location>
            <begin position="133"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX09325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="502" mass="54959" checksum="3A691B74DCCD8779" modified="2013-12-11" version="1">MTMQEPLLRPDTVPGPSPTRLGENTIALAKRLSLWYNETTFEIRDAKEPTDDTNSFCCGVGFGAQDQAIIVSVPLYNLLWIDVGASSVTIKYAAPAKASVKAASLTYPYEFPCHDEVEKWVMSLLDVAYGDAQSRKRCKVLINPFGGQGYAQQMFDKKARPILEAANCFLDVEVTSHHGHAIEIAQKLDIEAFDAVICVSGDGVPSEVFNGFGKRPDALTALRKLAVCQLPGGSGNAMCWNLTGTDDVAAATLAIVKGIRKPMDLISITQGRERLLSFLSQSFGIIAECDLGTEDLRWMGGARFTVGLLQRVIKQTVYPCDLAVKVAIEGKEEIRDHFRSRGNKQGGSQGETDEYIGDGLPPLRFGTVTDDLPEGWELIHQPNMGNFYAGNMTWMSAGAAFFPASLPNDGMFDLVCIDGTISRRKAVSMLLAVEDGSHFDLPHVQYRKVLGYRIVPHKREGVKEEYISIDGERIDFAPFQAEVHEGLGMVLAKSHVYDAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2H7</accession>
    <name>U4L2H7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative carboxymethylenebutenolidase acc. no. Q07505</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2H7"/>
    <dbReference type="STRING" id="1076935.U4L2H7"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="272" mass="30089" checksum="05036C6668AB3ACE" modified="2013-12-11" version="1">MLIKEYYEDVATTVEAGPMRIHFFRPVIPYYPDAKFPGVVVFSEIYQVTGPVARFARQIAGQGYIVAAPSSYHGHVGAEPLAYDGPGTDLGNNLKVTKTIESYDEDATLSIDALINSPFCNGKIGATGMCLGGHLAFRCAMDSRVSAAVCYFATDIHGGTLGKDMKDNSLERVRNKDIKGELAMIFGKLDNHVPPEGRDLIRKTMHEAGTRFSFYEFAWAQHAFIRDEFSKDRYDPGITKVCFEILLELFGRVLKTDLGAFNAGSFTVENRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2M5</accession>
    <name>U4L2M5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to DNA repair protein rad5 acc. no. P36607</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_09752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2M5"/>
    <dbReference type="STRING" id="1076935.U4L2M5"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="342"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="733"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="816"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX10159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="993" mass="111586" checksum="2743658FC05558E1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2V6</accession>
    <name>U4L2V6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial acc. no. P42116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935487">
        <property type="protein sequence ID" value="CCX09680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2V6"/>
    <dbReference type="STRING" id="1076935.U4L2V6"/>
    <dbReference type="eggNOG" id="ENOG502S7GA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNIQAGH"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17860" checksum="D384E2F4F2B843F4" modified="2013-12-11" version="1">MLSAVPRRVLLSGRRSIQQVRFGSHAAHDAHHAPAVPESFGKGFYMSIAAFTGLCAFYKFTVSDEKEPLVTRIINKYHSQSALWEARNTVHTKMVEEAAHDRLLFEESPIPKSRPYAYPEALNQGSPWNITAGWATGDLTAVKAHMEAERARLDALRQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Z2</accession>
    <name>U4L2Z2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_02008</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935202">
        <property type="protein sequence ID" value="CCX04405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2Z2"/>
    <dbReference type="STRING" id="1076935.U4L2Z2"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651066" description="Coatomer subunit zeta" evidence="13">
        <location>
            <begin position="26"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX04405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="21256" checksum="662A74F54A920D7C" modified="2013-12-11" version="1">MPTNLSLFSVTAVLILASDGSRVLAKYYNPPHSTTKSPYPTAKEQKVFEKGLHAKTVKSGGDVILYDNHVVVYKAESDVIMYVVGGLDENELMLFNVVLALRDTLLLMLRNAVDKRTIAEHYDMVSLALEEMVDDGVILETDPQLILQRVTKLPQSDIPNIKDIDLSEKGLLNAWEFGKKHFAEKLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L324</accession>
    <name>U4L324_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L324"/>
    <dbReference type="STRING" id="1076935.U4L324"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="180"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="381"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="497" mass="55340" checksum="6778163480E4F2F8" modified="2013-12-11" version="1">MVLNYSKWDNIELSDDSDIEVHPNVDKRSFINAKRRQIHENRHLRKQQIGHYQTEIAGNKHLLKMMDQLIVTLETPSDSPIEQTVMQALIQLTTQDHSDAPVVPPGAPGYSQMIASLVDTIKKEIDETNPDDRWKAFIGKLKEHRGKLLQQTKDTGVKLENLEKEDKDKITSEDIHEGFSSGHVNKPETKPAPKKKTTTKVQAVEQLNAGASIPPAGDQSVSSGAEADVEDVAGDDDEDEHIEPTELGKRFSQIKIGEYHKCLRFISENPDVVAEKETDGLLIEAFNSQMAGKDAYAKQCVHQALLLQYCRQLGRDGVSLFFKRITTSGHQAQKVFHDDVHQTYSRIRERAKEIASEREKGSQGVEQIQLHAVDPNTTINISIPAENSEDPEVQAARKVYESFPPGLRRALESGSLDEVNKVLGKMSVEEAEEVVGQLGEGGMLSLESQVIDATTEEGQQMLHEIEEQEKRAKEGGSGTDTTTKGKQREEDLAAEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L452</accession>
    <name>U4L452_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Catechol 1,2-dioxygenase acc. no. P86029</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L452"/>
    <dbReference type="STRING" id="1076935.U4L452"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMGPKTT"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="124"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX10509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="34301" checksum="ABCA72A0D3D4AC20" modified="2013-12-11" version="1">MSAPTDASAQRALSTFQSTLSDPFTNAVINAMSPETPERARVVLTSLIRHLHSFARDVNLLHPEWLLGVNTLNRAGQMSNDARNEGILVSDVLGLEALVDQITQDAMTSMAEGAAKEATLSCILGPFFRENAPLYQNGTDIVQKHSEGDEKLRTFMDGHIYDAETGKPIADAEVDLWHTNPNGLYEQQDPEQPEYNNRGKFKTDANGYYSLECLCPTSYPIPYDGPAGDMLKLMGRHPMRPAHIHIMVRKPGYATLTTQIYDRRDPYTLDDSVFAVKDSLIVDFKETEKKGVAYELTYDITLAKAKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4B0</accession>
    <name>U4L4B0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935595">
        <property type="protein sequence ID" value="CCX11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4B0"/>
    <dbReference type="STRING" id="1076935.U4L4B0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="14992" checksum="EE85A3049108FA40" modified="2013-12-11" version="1">MTISSAVDVPKGGLILEKYPEGKQFQKQVMRLSLTSEEILQKMLKPVNDLKIAFGKSMKLIVGDEEYSMMAEKVSEAQQPELYQVFGNKLNFVSTITHTLQIQDDTDDSANESEQKLKDSYDQLNQEKVVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5P7</accession>
    <name>U4L5P7_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935371">
        <property type="protein sequence ID" value="CCX07746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5P7"/>
    <dbReference type="STRING" id="1076935.U4L5P7"/>
    <dbReference type="eggNOG" id="KOG3399">
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    </dbReference>
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    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17877" checksum="D6FB8686C67D4FB2" modified="2013-12-11" version="1">MSLSFLFPRYLTPSLSPSSAPPHLASTLLACRVCHSHLCPSSSIISKTFTGRYGRAYLLSSSSLNTSTVTLLRPQERHLVTGLHTVSDYECARCGAELGWRYDDAKEASQKYKVGKWILEREKVREVRGAGDNVEETVQRLLRAGEEGIWEVDWEGGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5R5</accession>
    <name>U4L5R5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5R5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="16092" checksum="ADFBD705946424CA" modified="2013-12-11" version="1">MDIVEQEEMDQYWSQYPHRLCLCWSHAQRPFRLVDALLYELGTPPVIRRDVRKPTDPGNTNSAGGKPEALHLVIPTENTVSNQLFSRLKYRYPAYIAFSDGSALSEVTAESYNFSIIYKHLPEKSFGFLDFKRQSFALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4L606</accession>
    <name>U4L606_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Uncharacterized transcriptional regulatory protein C1683.13c acc. no. Q9P6I9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L606"/>
    <dbReference type="STRING" id="1076935.U4L606"/>
    <dbReference type="eggNOG" id="ENOG502QQZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTICIHA"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX07871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="709" mass="77953" checksum="5E87D815D07C47E0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4L644</accession>
    <name>U4L644_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized transcriptional regulatory protein C139.03 acc. no. Q9UTN0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935654">
        <property type="protein sequence ID" value="CCX11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L644"/>
    <dbReference type="STRING" id="1076935.U4L644"/>
    <dbReference type="eggNOG" id="ENOG502QSY9">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Fungal_TF_Env_Response"/>
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        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
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        </location>
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        <location>
            <begin position="819"/>
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        </location>
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            <begin position="109"/>
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    </feature>
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        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="841" mass="93637" checksum="0F5CEA275A03CCB1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6S7</accession>
    <name>U4L6S7_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to DNA repair protein rhp7 acc. no. O74999</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_11774</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:SCF ubiquitin ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="584" mass="62083" checksum="ADA509E30FC66C4F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L713</accession>
    <name>U4L713_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935732">
        <property type="protein sequence ID" value="CCX12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L713"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="146" mass="16465" checksum="F1AFAED8A04E6F99" modified="2013-12-11" version="1">MSSSIHPTDLNKTTTRWLFVLHSYFCQGGFRPLSRDSLVAWLQDCVARTFGTCPVAFELRESRFFLSCLSVYLRSDENRSLSALGDFGRLSDLVNLVKSGQVRLRRTTLSSHLYGSLVAPFGCLLVQWFPSVALWLLISNTVSCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7K6</accession>
    <name>U4L7K6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_13251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7K6"/>
    <dbReference type="STRING" id="1076935.U4L7K6"/>
    <dbReference type="eggNOG" id="KOG2907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMQYHTL"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX13658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="12942" checksum="84CF7F17AABC2B73" modified="2013-12-11" version="1">MSAVATLVFCSDCGNLLDRSPGSDKLVCQMCTAVSTDTSLKTTTTTSNERSFPSALRLKRSAVQTLDADDLHTEAKISQTCPACGNGEMWFFTLQLRGADEGATVFYRCECGHRFNTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7N5</accession>
    <name>U4L7N5_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651365" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13953" checksum="2DC9C5C1ED1199F4" modified="2013-12-11" version="1">MLAVFLSLLRFDFQCICGLDAIDIWALELLWRPFWLAKTSSVCMTPGDFNSCSIPCCVLDAVTKDGDRCGEFVTFLAWCEDFRHFLGCFSLLGRWHIVAFRGGICTWSRRGYWWMDEWCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7Y0</accession>
    <name>U4L7Y0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7Y0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="84" mass="9577" checksum="7D79FCE4AF56DFE8" modified="2013-12-11" version="1">MTGKWPSTHSPSSEPENRGTNERIQGKSQRGERNERVAERSLVKPRGRRRFLLSQLAEAYLFPFSFEIIPDDKCRGGMAIDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8C0</accession>
    <name>U4L8C0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ABC transporter ATP-binding protein ARB1 acc. no. P40024</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8C0"/>
    <dbReference type="STRING" id="1076935.U4L8C0"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="77"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="388"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX09623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="609" mass="67441" checksum="4BB51F1449962066" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8S1</accession>
    <name>U4L8S1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YPR063C acc. no. Q12160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="113" mass="12041" checksum="09CD206F17E065B7" modified="2013-12-11" version="1">MAPQQFKDKRSAELIIPYTPAEYNPEEHTMSNALPMAAMFTRNKMVGWTAVVFAIQSWMSESSDSIASGKQPGIFAVGISLMSLAVTYIPVFFPTMPAGPGATGTDAPAPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L918</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935302">
        <property type="protein sequence ID" value="CCX06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L918"/>
    <dbReference type="OrthoDB" id="10344063at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651218" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9018" checksum="AD4554A401E61E78" modified="2013-12-11" version="1">MKIFSIALLAALGATAMTSALPQSKSLEIRDETDYNGDLADKQCLWSRCTIGGKIDCRPGYVDSGKRRTCGRAMMVKILCCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9A8</accession>
    <name>U4L9A8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="110" mass="12155" checksum="0E3C89642457B38E" modified="2013-12-11" version="1">MHMRFAVASLATVSGMVVVVVLPVLISPMMVMIGLFVIVMSIATMLFMPSMSTLIPENPRFYRRTGIVLIPPIVLVSLLRIVLSRSITREEVCEGFRSFGILFVLIAAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAA4</accession>
    <name>U4LAA4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LAA4"/>
    <dbReference type="OrthoDB" id="10537508at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="504" mass="58078" checksum="D25772F66BBF9A1A" modified="2013-12-11" version="1">MSTGLTLSNGIPSLITANITTGAAILAMANITTSLTSMASISTEVPTASITIGDTTITITTPTTSDLVMTSITTATPLLVSWSIIDSSATPIQQPTAPARFPAETVPPIPSGTKTYVRTSLDLDHHKRALWDGVTGDPHMCLLIEMFHEGFNKVIFSKHHPNNTAMHQYMDHQRPPGNSSKTVWKPRLYPWTDYVLSFAIVGPIPDAPGCCEVTNMGLTLECKESCLSPFWWWYGVILQCVTALVIGIFTLWKIRTTYAPEFSRLWWRYHRWRCENCREIQRRNEAFAWYRHLKNEAEWKFMEEARNTNDAVKKTEIYQKEIIKDQDRPIIPEWSNYYRMFIRGDLDAKYQYQREIIGRTGSDWMQSSFQTLMEQNQQVMHDYYLQEYAERYDPHAEYRCAYYTFQEWRAEKRRITRAYQAQTRRELLEEEEANWEDVDTDEEGTDDSDDDCDDDSDDDSDEDSDNDSDDDTDDDSGDDSDDYGSDDDDSDDSDDSDNLDEYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAX3</accession>
    <name>U4LAX3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAX3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="6144" checksum="18F89F25E0AA0BB5" modified="2013-12-11" version="1">MLFKGSYASTSVMNCAFNIREELLKKSLSYAFYFQSNRLSIPYRIDMLLTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB07</accession>
    <name>U4LB07_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Tubulin-specific chaperone C acc. no. Q8VCN9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB07"/>
    <dbReference type="STRING" id="1076935.U4LB07"/>
    <dbReference type="eggNOG" id="KOG2512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFQHEIT"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
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        <property type="entry name" value="C-CAP_CF_C-like"/>
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        <property type="entry name" value="CAP/MinC_C"/>
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        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="129"/>
            <end position="276"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="321" mass="34595" checksum="370AC9E062BD3D97" modified="2013-12-11" version="1">MTSLQNLQTVDKDTIHSTFNSEYRALEALLLSLPSLSAPSRPPAIDNLLSGISRLSSLLQDASTYLPAYDQRSYSLKLKTLSDQLSTVRTQLAPKAKFSFKSRKGDGGKGIIGGAVGLGTSGGGGAVNTAAEKVAAEQENLKLADITGQHIRPSAGAVSSAASLLVSSIKDSVLVIPEELRFSSASVKDISNSVLLLGRSVNGPVHLTGLRNCVLVLGCRQFRMHDAQQVDVFLGIGSRPIIEDCEGVRFHKYGGDLGPDGQERGNMWDQVDDFKWLKNGVNPHWKAVGEEKDEVWAEMQGKEVGQLEVQKVLEELIKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB34</accession>
    <name>U4LB34_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936252">
        <property type="protein sequence ID" value="CCX15736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB34"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="8881" checksum="6A71830DC2E3016F" modified="2013-12-11" version="1">MNQHGEEGIVPSGNTTAQVEQPHQQSVEKQLPDTSSHTTTGNNAVTTLSIEIVVQIAVQPSYSVETWLAQSREDDGVRVYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB60</accession>
    <name>U4LB60_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_06993</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01489">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="15">
        <location>
            <begin position="16"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="16">
        <location>
            <begin position="303"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="17">
        <location>
            <begin position="437"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="593"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 13">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX07404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="649" mass="71932" checksum="7752003EB91293F1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB84</accession>
    <name>U4LB84_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Guanine nucleotide exchange factor SRM1 acc. no. P21827</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB84"/>
    <dbReference type="STRING" id="1076935.U4LB84"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDQPHEI"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="321"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="585" mass="62697" checksum="9604106D805D63CF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBU7</accession>
    <name>U4LBU7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Protein PLANT CADMIUM RESISTANCE 7 acc. no. Q9LS43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBU7"/>
    <dbReference type="STRING" id="1076935.U4LBU7"/>
    <dbReference type="OMA" id="CERVPFP"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="258" mass="27986" checksum="26A1FA6022F7CCFD" modified="2013-12-11" version="1">MSSSIPAAATDSKTAHLLQEEEPAPIEAPPSYADSSKPAPPVIGDGNVFSDLPRPGMTRPGMTYGPGQAQVYIPRDRKGTWSFGLFSCFSDPAAAIKACFCPCVSYGQTRHRLHNPNSEAPVFSTPCLGYCLTGSFIPGAESIFGLLNRNELRQRLDIDQPPQRIVLPGGRTAPPNNVSMFEGVQSAIGFAHDSAAHLFCGCCALTQEDREVRLWERQMEEEGLSDLRGLRQDEEEAVLAEGDHLLGSERSELRGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCF2</accession>
    <name>U4LCF2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCF2"/>
    <dbReference type="STRING" id="1076935.U4LCF2"/>
    <dbReference type="eggNOG" id="ENOG502SP5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNDIHIP"/>
    <dbReference type="OrthoDB" id="4540679at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="36757" checksum="1C87586A0726B176" modified="2013-12-11" version="1">MATLPGVKKASSGAFYYDDSDINMINIPIGACEGDYVLTPAELKRYFGLNADRIGKLPEYLMYPHLNSTWNRARKKSTGRSWWNITGEIVAYRPIQWIPIVNERDTVPSRYFDTEYNKPTKKIQTDEIYGRAAGTDLFELSLGGKWKGMKCERSSTSSIEIEAIYITPAEVLKSNRGNLVIKEIVLGMALQVERVFEHAVTMYLNDEGKGDSLTWDGPESFNDVWVASNSLRDVGSLQFHPILMTGTGHSDSLWIQVLPVFDESKKLTDMHTVVSCKGWKNWHAYTHGSKVRNSGRKETLPLPKSKKPLVTLVAAAGELDWENELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCK9</accession>
    <name>U4LCK9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Linear gramicidin synthase subunit D acc. no. Q70LM4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCK9"/>
    <dbReference type="STRING" id="1076935.U4LCK9"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWFFPEG"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="574"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX16641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115522" checksum="46373A6691E9604C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCR9</accession>
    <name>U4LCR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06334</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
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    <dbReference type="STRING" id="1076935.U4LCR9"/>
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            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="167"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="763"/>
        </location>
    </feature>
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            <begin position="303"/>
            <end position="314"/>
        </location>
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            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
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    </feature>
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    </feature>
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            <begin position="494"/>
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            <begin position="530"/>
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    </feature>
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            <begin position="574"/>
            <end position="584"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="750"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="763" mass="84759" checksum="7C3584045D67E7C7" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652148" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="131" mass="15294" checksum="E916A17C01CB54DD" modified="2013-12-11" version="1">MHLLPSPPPLVLLLLASTISIFASPIADPFQRDPNEQTIVELFNGYHYDGHRTMFHHKRWSDSGCQNLAAPDQKTTKSFRVTNGCCEFYFERDCLKWSYMWTAYNRKDGELEGRHRNQVTSYWCNGRTCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE99</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
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    <dbReference type="EMBL" id="HF935778">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="123" mass="13525" checksum="709DF28CA2D32198" modified="2013-12-11" version="1">MRTSRFALRIFFGFHLAKNYTFPPQLPQLPQPFNTTTHTMAKRSARSKQSKTFATKVSKASKSKATKIKNGLLAENIDAILVNEGLLPGKAQNDKLSKAMSNVKATDDKSKAVDDLMDQLGGL</sequence>
</entry>
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    <accession>U4LEN4</accession>
    <name>U4LEN4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized protein C9G1.06c acc. no. O14302</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09332</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        <location>
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        </location>
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        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
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        <location>
            <begin position="480"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="599"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX09739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129202" checksum="6D92107F48939CF3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEY9</accession>
    <name>U4LEY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Beta-lactamase-like protein 2 acc. no. Q54VJ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30423.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEY9"/>
    <dbReference type="STRING" id="1076935.U4LEY9"/>
    <dbReference type="eggNOG" id="ENOG502RX9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIREDWR"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651393" evidence="2">
        <location>
            <begin position="17"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="69"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="424"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30423.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="557" mass="59838" checksum="940595FBEC22368D" modified="2014-03-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFB0</accession>
    <name>U4LFB0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFB0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8010" checksum="148B28BBAC129DAA" modified="2013-12-11" version="1">MGLLLDATSKYSTISRPACKCTLRVPKTIACLFPVEGSTLTPGVSSTGEFVSPLDFCTDLFADSVYINHSFIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFP3</accession>
    <name>U4LFP3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized WD repeat-containing protein C824.04 acc. no. Q9UT39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFP3"/>
    <dbReference type="STRING" id="1076935.U4LFP3"/>
    <dbReference type="eggNOG" id="KOG1446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNEGYIR"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001194">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="367" mass="41294" checksum="368ACE2041FB350B" modified="2013-12-11" version="1">MPPSLTSSRPHRERESIKLSETIHRFRPSKSFSNISPGAEITSLDFDDRGELCIASADDETLQLYDCISGRHQKTLFSKKYGCHLAKFTHSSSNIIYASTKGDDTIRYLSLHDNSYIRYFKGHRRLVNSLEVSPVDDQFISCSADDTVRLWDLKSSNCHGLLNLPSPSLAAFDPSGIIFAVASQASSSIMLYDLRNYDKAPFTTFTITDDAFLSAYSYPPRMPQWSKLEFSNDGKLMLLGTRGHSHYVIDSFAENTSKFLYRVLRPRGFTLPEKEGKETSGSVCFTPDGRYIVGGQGERGVAIWDTNKQPDEKKSLLPSWDLVENVRTQASVVAFNHKTNLLATAYKEAVFWLPEQHAPDPPQSPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFR9</accession>
    <name>U4LFR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Long-chain-fatty-acid--CoA ligase 3 acc. no. O95573</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFR9"/>
    <dbReference type="STRING" id="1076935.U4LFR9"/>
    <dbReference type="eggNOG" id="ENOG502RVGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADWNIYT"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="540" mass="58345" checksum="712C180B485CF9FB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFT0</accession>
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        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">PCON_10092</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">CBS 100304</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="9">trans-Golgi network membrane</location>
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        </subcellularLocation>
    </comment>
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        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Syntaxin 10"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
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        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX10498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="230" mass="25569" checksum="91B30C3B5B84939E" modified="2013-12-11" version="1">MSSTTDTDPYIQFQSEVQSLLSSTRASFTNFLRLRSLSASPSDLTSARHDLSESLTSLSDDLRDLGAAVKAVEKDPYKFGLDVSDVASRRRFVEESTGELEDMKEELASIDAEESRPKYGGFVGDEDEDLAERDGNGIDASDPVSVFEHQQQQTIMREQEQQLEGVSRTVGNLREQAFVMGRELEEQQEMIESLDNDTERVQGKLGRGMRDLERLIKANEGTLCSGRCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG63</accession>
    <name>U4LG63_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to Chitin synthase regulatory factor 3 acc. no. Q09897</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG63"/>
    <dbReference type="STRING" id="1076935.U4LG63"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CCEIGAG"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="906" mass="97934" checksum="77C79F6C5BC9F3C5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGB6</accession>
    <name>U4LGB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935546">
        <property type="protein sequence ID" value="CCX31154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGB6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4355" checksum="2C5C68AF1DC7B299" modified="2013-12-11" version="1">MVDLRGLWRHLRGFGVQDDIFRVNLECVASGWLTGAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGS6</accession>
    <name>U4LGS6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Choline transport protein acc. no. P19807</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGS6"/>
    <dbReference type="STRING" id="1076935.U4LGS6"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GIMLQML"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF15">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="526" mass="57220" checksum="7A497D2913F840DF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGZ7</accession>
    <name>U4LGZ7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGZ7"/>
    <dbReference type="STRING" id="1076935.U4LGZ7"/>
    <dbReference type="eggNOG" id="KOG2969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CAGFGWN"/>
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    <dbReference type="UniPathway" id="UPA00232"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX15588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="28198" checksum="9B237EE25CAC0C96" modified="2013-12-11" version="1">MAALLPRLVRQSTRQCARLPILTQTRTFTSTERAAPSVYTPLESALLSSALSHVPEHGFTSHSLALGARENGYLDISINLFPKGTFDLVRYHLVQERMALKDKVDLSAAEQAGRKLGMTEKIRSLVKERLRGNEKLGGRWQEALAIMSLAENVPSSISELAALSDEIWYLAGDKSSDSSWYTKRAMVAGVYASTEVFMTTDKSPDYRETWEFLDRRLEDCATIGKLAGEVGPYMGFTASAVFNILRSKNVRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIE1</accession>
    <name>U4LIE1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIE1"/>
    <dbReference type="OrthoDB" id="10397873at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="689" mass="76089" checksum="12FE1B70991A161C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIH6</accession>
    <name>U4LIH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIH6"/>
    <dbReference type="STRING" id="1076935.U4LIH6"/>
    <dbReference type="eggNOG" id="ENOG502RXIB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGMGATH"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="275" mass="31365" checksum="7A840110225C8525" modified="2013-12-11" version="1">MGSRSSSDLNLHDEDKLLSSSSPYDTHFTSYNSRTHRPRRRFLNWRNISVILSSLLLLAGISVWLHVILLVKNMHCKTTPEEEKFEPDLRYSRRVIFQMHKFYGGPPSNATNEMWERLLPPGDGIVALPEKFTKSLPPSRPGDEEGTYVYGISMFHQLHCLNFLRFAYYPGEVKDMPPDEVVLHRDHCLDYIRQAIMCNGDATFEPLKEFGVDGMGAIHQCRDFDSMFTWAYEQRSNKTDSGYESSTRTHTPAKLNTVGGGSSGHSHAHLGGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIJ5</accession>
    <name>U4LIJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pc18g05810 [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002562408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIJ5"/>
    <dbReference type="STRING" id="1076935.U4LIJ5"/>
    <dbReference type="eggNOG" id="ENOG502S4NJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="429" mass="49700" checksum="EB5CC6B5CCAFAC36" modified="2013-12-11" version="1">MEQPMHQPRHIPMPPQVTRGYYRAPYGHSQGHAHCGNTAAPYNFNDISQISPPNQFENHHTRFDLQQQQYLQQQQKFQNQNNYYHHPTQSSYMYTWEPPTPIKTRARASSRSSRGSSTSSRSPILDDQEIEEKHKLGDREFSPLPPPAHVDPEVEEPCNDDSIPRATYRGNGTRNTVPLPHPQDSNRTRRRTNSNANNLNGAETTQTKFRKGGAKQECYVLRMQDDYQVDIPEEETTAISDPLFTLSDGEYREIFTQLGNIFCHTAYRWLALYKFRIPRKKYMREHTCPDDRELTEYVTIIKSLVEGREVPRNAVRDDRLNELISIMEGASEIRHVNIHVSRKKKPDRRVLGFIAAVNEFCWILGDHRGAAETNKLYADTEAKSLENRRKFHEDARRKQIASLPMDTLRRNSTSRSPERRPSSGYPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIM7</accession>
    <name>U4LIM7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIM7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4296" checksum="026A418DEA34D6F4" modified="2013-12-11" version="1">MLYELCILNTSVFSGNWLHRLRYFASSLSRPVLPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ22</accession>
    <name>U4LJ22_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Probable mRNA-splicing protein ubp10 acc. no. Q9USR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_03541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936522">
        <property type="protein sequence ID" value="CCX16796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ22"/>
    <dbReference type="STRING" id="1076935.U4LJ22"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="224"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX16796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="558" mass="63612" checksum="0FEB956AA78AFBF0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ25</accession>
    <name>U4LJ25_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Alpha-latrocrustotoxin-Lt1a acc. no. Q9XZC0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ25"/>
    <dbReference type="STRING" id="1076935.U4LJ25"/>
    <dbReference type="OrthoDB" id="3271094at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="478" mass="54238" checksum="EA9281147FF2E946" modified="2013-12-11" version="1">MDALERAVPIPFLVCTSKESFHDMLELIFRGLPGHGMVTGGKYHLEKHKTGEVIEASEWPNIVAPGSTIVMSDIVRKIVYDDHLPPENRTRDCPRCGEKLNHLVKTSMRCPRCFKDVRFTRVTRQLGTGYSTIQPSRPPRHKLRRKDFKIINKPEDKQRPQNNSSKSNESSDLLTFQRVHMIHEELSGSQQIRVGTMDFELSALAKGYNLDPTLAGVYAMILGGSLYDWEYLLRHVMDVEQRCDDASHRQQFDNFTLLQLTLAFKKFELVEFLLQAGANVNAPAAECRGGTALGIAAQHANREMVKLLLAAGACVIEPIHSNALTTLEYTIWEGHVNGIQLIIGAGTNVNNVSYLRLLLYCLTYHYRDGVQESLRRIVKGLGDLEVDHIHRVNMLQFLRIGSKSMHSEDGEGNYDSDNHEVYSRKGEYGENTRDRRNCTCLHNVVKEKDIEWGKEILRDLAMDTLGFRVEELSDSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ50</accession>
    <name>U4LJ50_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Kinetochore protein mis14 acc. no. Q9P6M3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936576">
        <property type="protein sequence ID" value="CCX17121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ50"/>
    <dbReference type="STRING" id="1076935.U4LJ50"/>
    <dbReference type="eggNOG" id="ENOG502SA1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EVQRNWE"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="288" mass="32799" checksum="F48E4837D80616F2" modified="2013-12-11" version="1">MLIQQAPTRDALNHRAAQTNANSERGDETRACKASKDIHTRTHNTRALARVPVESATIEHPIHRQRIATPPHLYQFAKMEAEKMRPIELQSPEDLRYLIGKVRSAAAQNLSKLPPSQDPAMMQRVEELLDEYIMNVFTRALPNLTINGLPPNLPITAYMQPVEEFEPFDSRLQAAVVSLHMEIEQRTLQLTAMRRDAPTQLRELFDNDWTAEERRGEKLTKSWEEKLNATEPEGLVVRDVERHEEAEATKKKAEAGLQEIQTDLTRVLGRLTRASAAANYILEKERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJL7</accession>
    <name>U4LJL7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJL7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651495" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8299" checksum="11C65DF593143B30" modified="2013-12-11" version="1">MYSSNYVLTISLWLFLTAFTGQSLRDRVIFLADLLYPFSNSEGGPIMSHFARLSLRTTLHAAGVYAGKLSATPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK82</accession>
    <name>U4LK82_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK82"/>
    <dbReference type="OrthoDB" id="10485447at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14444" checksum="1A581F88549AEB00" modified="2013-12-11" version="1">MPAENSYEQFVDFSAEASTPGFDTPSASEIMSTTPTANLQISSPAYENMFRSFQDTFASLRAEMAMLEIENKRLVEHNTLIKKELETLDKENVKLSGANDDALKKLAEVEEEKAGLQKELSGFEGLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKS4</accession>
    <name>U4LKS4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_12864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="HF935793">
        <property type="protein sequence ID" value="CCX13271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKS4"/>
    <dbReference type="STRING" id="1076935.U4LKS4"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQNCIDR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
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    </dbReference>
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        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
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        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
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    </dbReference>
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        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="290"/>
            <end position="490"/>
        </location>
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    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
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        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="301"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
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        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="8">
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
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            <end position="424"/>
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        <ligand>
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        <ligand>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00031113"/>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX13271.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="514" mass="57115" checksum="CA0BF3979BD24A8B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLP6</accession>
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        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C19F5.03 acc. no. O60162</fullName>
        </submittedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="590"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32512.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="690" mass="78100" checksum="96A82256EA65D66B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMA6</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_01284</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
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        <location>
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            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="29484" checksum="DD81BB202B077741" modified="2013-12-11" version="1">MPGITDYEHSPPRKRVRKFKKLRAFRLDPYRWNKQYCEIIGTIFTYGVQTFLSIPLPAELLAAATSTIYPEALEFLWTFTDNDYRLIASTSYDIFDSRTDYAFMQSRDPGLMQQRQWLALQLVEEVLIQLCPNYKVLEYQLKLKYRQQEAWWDPRGVVSHIWVVEPRRRSPCFSEEAAYAISIAQTLQNQENIRDPAIELEFWMISVRGTKIAIIKVVVMVWMLQILGSVIRMFRIGMGKRYEEGGVEYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMR0</accession>
    <name>U4LMR0_PYROM</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">PCON_14273</name>
    </gene>
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="1076935.U4LMR0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="954"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
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        <location>
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    </feature>
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            <end position="1091"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33233.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1091" mass="122491" checksum="4F3DE5D1497BCCA2" modified="2013-12-11" version="1"> </sequence>
</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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        </source>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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    </evidence>
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            <dbReference type="EMBL" id="CCX33599.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    <sequence length="97" mass="10838" checksum="E4078D989DAA45C6" modified="2013-12-11" version="1">MLLKLGSCEKTGRPAATLTLDSTKARDKKTQEIKITIEEVEEEDSDGKHPKDEDADETNTGVTLCDTSFICFSEPIVMDDQSLLFTAFTTFKIEDKM</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX30960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10108" checksum="0E84C83F014D5EF5" modified="2013-12-11" version="1">MLKGKVVQTLLSHRYHDQAAGGKMETSVDVVQVDTLVWRLLFLEWTLVVGGYGEEWTRGLSALHGSRFTGGGGDSFRTPLEADREDSVWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNT0</accession>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="STRING" id="1076935.U4LNT0"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00439">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="262"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="577"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="848" mass="97097" checksum="F2BEA5D64D614A00" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPN0</accession>
    <name>U4LPN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to 2-epi-5-epi-valiolone synthase acc. no. Q9ZAE9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPN0"/>
    <dbReference type="STRING" id="1076935.U4LPN0"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCAHKPT"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="7">
        <location>
            <begin position="195"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX16645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="49976" checksum="C85CE886790FBC25" modified="2013-12-11" version="1">MSDLKATVSETENGFHVEGYERISYGFSFLDGVFNPERNELAKMYQPWKRCLAIADANICELYGQQMRGYFQHYGIDLTIHKTKIGEKAKTMDTMLAICTAMNDFGIIRKEPVLVVGGGLITDVAGYACASYRRTTNYIRIPTTLIGLIDASVSIKVAVNHCGHKNRLGAYHAPMHTFLDFTFLRTLPEAQVRNGFAELIKISTCADLRTFDLLDQFTEKLISMKFGRADGSSQELIKAADEINRRGIHVMLKLETPNLHEIELDRVIAYGHTWSPTLELAPETPLRHGHAISVDMAYSATLAFMRKEISSEEHRRVLGLFSKAGLTMMHPLFTPELLVKGTEAIMKTRDGRLRAAIPYPIGSCKFLNDISAEEMNAALKMHMDFCKEYPREGAGIDAYVDSSDTGVSMEADEKDPVTGGMKIGGTFDAKAEMNKLKEEIAGAVGGNECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQE3</accession>
    <name>U4LQE3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to DnaJ homolog subfamily C member 7 homolog acc. no. Q9HGM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQE3"/>
    <dbReference type="STRING" id="1076935.U4LQE3"/>
    <dbReference type="eggNOG" id="KOG0550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KMCLGLD"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000055">
        <property type="entry name" value="DnaJ subfamily C member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="390"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="524" mass="57581" checksum="E9CF330494C0E847" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQF6</accession>
    <name>U4LQF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQF6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="12853" checksum="5DD9DF4FAEFD5F9B" modified="2013-12-11" version="1">MLSPASAIRKLARREIQGLATAPRGYNRDLMALAIRRFPFSLRPQPQPKLELGVFLKTGVDHKVMVWIAGGLANGVSPVHSGMFEDLDDLGHYADPGNNTNQGPFTGKNRSYEYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQP9</accession>
    <name>U4LQP9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQP9"/>
    <dbReference type="STRING" id="1076935.U4LQP9"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="74"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="386" mass="42153" checksum="525FE0AEABF7CFE3" modified="2013-12-11" version="1">MSDVEDMDIDSVDAPAAVTFSSDLKGKKMSKANLPVSAGDTLPWVEKYRPDTLSDVSGHEDILQTINRFVSSNRLPHLLFYGPPGTGKTSTILALARHIYGAKNVRQQVLELNASDDRGIDVVREQIKTFASTRQIFGGVAGKNDGLGNFKLIILDEADAMTSAAQNALRRIMEKYTANTRFCIIANYTHKLSAALLSRCTRFRFSPLPVEALRRRVDVVIEHEGVKITPGAVDALLKLSRGDMRRSLNVLQACFASSTPLDDAGRPDTTKEREEITESAIYDCIAAPHPEDILMIMETLLKSDITTSLRAINEIKTRKGLALADILAALSEELCRIEVPKQTRVLWMEGLAEIEWRVGSGGGEMVQTGGLAGVVRKGVAVMGNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQQ3</accession>
    <name>U4LQQ3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQQ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651684" description="Prion-inhibition and propagation HeLo domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37730" checksum="8DCEC15C984069EA" modified="2013-12-11" version="1">MPVAEALGLALGGASLALAFESVLATMNHITTARDFTKDYAHFRNCVEIQKWKLIVWERDGQHWRLMNEAIAGGALRVLGGIETQLQELEGVIVVFEGDLKGFGKNRRGSGAVMSLETIGMGSRSTVSIMAPYRVSKASLSKKFRWTTTGKEKANAALEELRKLVEELYHFVPVNDPVGSTIDTPLQTTSQCQSTDSCHCPQIVELAYGEPQCSHALGLNPEGSWEDLETMRNFQGRHDQLVLIKTLQKELDIYRSIAHQRFPRTRTMKMKKGLRPATGRVAKRRGDKRQHQTALVSKTDRIGDHFEEALVRQMADAIHAARLYSNWVALPSAYAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQZ5</accession>
    <name>U4LQZ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQZ5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="16073" checksum="4981E6CCA5C3D997" modified="2013-12-11" version="1">MWARQRTTSCRRVLSFRSCEATDSVLQARQERMAQEDRSQQAPDHLNRLAQGTNLAPSTTTFDSTNSVPSSTTADTTNSITADSTEGNTNGTSLSSESPAGKSKMSQVLQDIFNLVYVVSLPFTSVIWLASKSFESLIVNDDVMNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRK5</accession>
    <name>U4LRK5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_03018</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936392">
        <property type="protein sequence ID" value="CCX34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRK5"/>
    <dbReference type="STRING" id="1076935.U4LRK5"/>
    <dbReference type="eggNOG" id="KOG1145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIVCYQI"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00025162"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
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        <source>
            <dbReference type="EMBL" id="CCX34204.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRQ6</accession>
    <name>U4LRQ6_PYROM</name>
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        <recommendedName>
            <fullName evidence="7">Cryptochrome DASH</fullName>
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    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May have a photoreceptor function.</text>
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    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
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        </cofactor>
        <text evidence="7">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
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    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA photolyase class-1 family.</text>
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    <dbReference type="GO" id="GO:0071949">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:photoreactive repair"/>
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        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
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        <property type="entry name" value="DNA_photolyase_N"/>
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        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="631"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="296"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="631" mass="70769" checksum="36FA040908F93A3A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS19</accession>
    <name>U4LS19_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_04259</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936618">
        <property type="protein sequence ID" value="CCX34750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS19"/>
    <dbReference type="OrthoDB" id="10525253at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="12548" checksum="709BFAC02A75A36F" modified="2013-12-11" version="1">MKLVLLLRGSPFYHQHPPASTPLHFITRSAVALQQLLLSNSTYTMPSGQNPTPAASTSGAQGAQAPGAGGASTPPTAVDPPSPSLTLEGLASLNTTAKNPFDRWYSQEHQEEATVYYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSP8</accession>
    <name>U4LSP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSP8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="14410" checksum="EF31759F79C8CB4E" modified="2013-12-11" version="1">MPIHRTVHLRRSVQNGPDGQPSTFHLTSSTVRERDTTSNTNTRADGLLAGISVGNPDASFVGPNKKITTVGQGFSGGSDTPAEQGSAAREDNVESQASEFNINNIAKSAGERVQNIHKNLRKAGAPLPDTVRWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LST8</accession>
    <name>U4LST8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase rok1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_04221</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LST8"/>
    <dbReference type="STRING" id="1076935.U4LST8"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRAGEIW"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="257"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="476"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="647"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="706" mass="77066" checksum="0225C71CFA6A3E29" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTJ2</accession>
    <name>U4LTJ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to 60S ribosomal protein L5 acc. no. O59953</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTJ2"/>
    <dbReference type="STRING" id="1076935.U4LTJ2"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="298" mass="34086" checksum="96B0660B12150554" modified="2013-12-11" version="1">MPFTKLVKSSAYFSRYQTKYRRRREGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDVICQIVTSEIIGDKVFAAAYSHELPRYGIKHGLTNWAAAYATGLLLARRTLTKLGLDGDFAGVEEVDGEFKLTEAAEIDGEERRPFKANLDVGLHRTSTGARVFGAMKGASDGGLLIPHSESRFPGWDIEAKELDAETLRKYIFGGHVAEYMETLADDDEERYKSQFQQYIEDGLEADGLEEMYEEAHAKIREDPNLPAEGEKKDAAYWKSESQKYRSKKLTREQRRANVQAKIKELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU44</accession>
    <name>U4LU44_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU44"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3763" checksum="CBF744496D8B2CA8" modified="2013-12-11" version="1">MSTTITSDEVDRRIEMAAKRVVGAMHEHGLRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU68</accession>
    <name>U4LU68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C4G3.03 acc. no. P87229</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU68"/>
    <dbReference type="STRING" id="1076935.U4LU68"/>
    <dbReference type="eggNOG" id="ENOG502QPI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="813" mass="90253" checksum="C3D1CD60663E44B2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU82</accession>
    <name>U4LU82_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Envelope protein 165 acc. no. P0C9W6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU82"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651911" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7126" checksum="59D9F844CDB50C85" modified="2013-12-11" version="1">MKFLALIPFVFALTAIATPESQPIEELVPRQKQCKPRGTSCRGRGQCCPGFYCTSYSGRPKACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU94</accession>
    <name>U4LU94_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU94"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="230" mass="26861" checksum="DBC3FCDCB43FE911" modified="2013-12-11" version="1">MSTASITSLGESLAAKQLLQRATADYHSTFTKYFNGDLSLSQISNHEHLHRLMNTLRVISERNYDPKVLTKHEANEQMKAVLIGILQVTLVIPKFPLTDYEDAVRQVELRQAAHMEFMRECVKECKGYMDPENAEEFIERMFEETLVVQTDFSKIVAQRQAVGYRDFLEEMRMELPWAMTKERIERLKQEARGGDIEEDWVMMDIDDNWGENTILCGNARQSREAGWKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUI4</accession>
    <name>U4LUI4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUI4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="244" mass="28233" checksum="FD0A6B9A2D580117" modified="2013-12-11" version="1">MIISTELEDVTLHFPLFPDYPRNFQTEEPYMLLKSSRAFGWEIRSLFRFVAGPLRVALENPKYEDPTWCADIKRFYAAAFFIAGVDDYDLIADGVNLGHTDSTEAVDVISEFFFGKKEKIGFFELEECLSFVQSNWCRYLREVQTAKVQDKAKTVRLQERRDLERMLGYVKENHALKGIVVLDEENWDELCDMARDNLESWNSGQPLVAHPQYRFSLDHLPLNRETSPGDLNRMISVGSMGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUK1</accession>
    <name>U4LUK1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUK1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="11438" checksum="7F99781D5B3B3783" modified="2013-12-11" version="1">MLNRTVVHPSLSDTPFHTLLLTETQLDMIIAGAEPGQFFPRFHIRCILILPYYQPQNRIPAPTLTLEHLRSIEMIENYFMDTWYDQDKKEDGVVGYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUV4</accession>
    <name>U4LUV4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUV4"/>
    <dbReference type="STRING" id="1076935.U4LUV4"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFIEWQF"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="209"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="824"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="974"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1108" mass="124542" checksum="BF87D7C4DE464380" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUZ8</accession>
    <name>U4LUZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUZ8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14461" checksum="B18620F41DA327C2" modified="2013-12-11" version="1">MKDHASLNMIIRAVSGLLVMKLASSTYDAVILWRRLGIKYQNVITLRLRSIMAVMLSFSDLLEHSAKMHILRPPAVLRNAVYPGYHPTTVTAIGASWLCAGGVFLHYSIHKGRALPGYGVQTHQLFGIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWE0</accession>
    <name>U4LWE0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWE0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4977" checksum="BBE011E1FBB0A3FE" modified="2013-12-11" version="1">MLIIFVIEDLYRILPESLCIQDCAFFFTQRACVARVARCDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWP1</accession>
    <name>U4LWP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWP1"/>
    <dbReference type="STRING" id="1076935.U4LWP1"/>
    <dbReference type="eggNOG" id="KOG2722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VLWFTMM"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="416" mass="44692" checksum="E43DC9BA56A80A1A" modified="2013-12-11" version="1">MSSAIAASSLGAFQAALSVLLTLGYGVFAARYGIINSGTAKDVSQLCVKMFLPALLITNVGKQIDRENITNYVPIFVWSLVYHVMSLAIGKTAEKTLGLPSWVAAACTFNNSTSLPLLLTKSLTATGILGSIAGGDVEKAVERAQSYFLLNSMVSNAATFAVGPKLFDVEKDREEDGDEEDESDEEDDQEEEADENTSLLPKPITTRISSVESSAENQFHRLPHPVQSVLSYVGSLVNPTLCGAIISIIVGLTPPLQKALFAPTQEGGWLNAWFTSSLKNIGELFTSLQMFVVGTKLSDSLTSKKSANPPKKALAVIFMVRFVFWALVSIPTIYMLAVKTNLLGDDPMLWWAMMLQPIGPPAMILSSLVEVAGVGQTAKMKVARTLTYAYIITPIIFAAVVGALKACEAVLDKRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXB7</accession>
    <name>U4LXB7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Polycomb protein EED acc. no. Q921E6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936516">
        <property type="protein sequence ID" value="CCX34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXB7"/>
    <dbReference type="STRING" id="1076935.U4LXB7"/>
    <dbReference type="eggNOG" id="KOG1034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRQVAWS"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="51526" checksum="806423E0AD6CD277" modified="2013-12-11" version="1">MATTAKSSPSQEDDPWAYPAQEWLVVPAAEQKSSKDGGDEDASLFDSTYYGVYFYPFSATVMEYPIFAVVGGDQVIVVRASTERYEVIRRFKDDGFGGKGLYCACWTRDPKTGDPLLVVGGKSPIIKVLNVKTGKCVRLLTGHNDEVNDMVRHPINETVIATTGSDYRIILWSLNPKHKKQPISIIITGIHGHVQNILTLDFHATGRYLLSGGMDNRINMWVIPEDPAEGAGKENPTRIVRPHFSTNRIHSNYVDCIKWYHDTILSRAATENKIIHWKIDGFNSSSPCPSLLSAPIRTSATLRDTINYFGCSSYRRIQQFSAPNTIPWYLRFGFLYQPGLHPMIAVGSTDGKIYFWDMEMLYQFGKCKGKWVGHGENKYPELEGARSSDDEELMEQTRPKKKFIKRDNLGNLFGLVNPHHIVKVKGAHATPFRNVVWSADGRWCVAVGEGLQIVVMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU15</accession>
    <name>U4KU15_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU15"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="6065" checksum="A4B56AD16A3A60AD" modified="2013-12-11" version="1">MNPRAATRKHTARATGDGRRETLMAFHGFRWLRWRRCTVLPIDAAGKRWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU50</accession>
    <name>U4KU50_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_03649</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU50"/>
    <dbReference type="STRING" id="1076935.U4KU50"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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    </dbReference>
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        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
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        <property type="entry name" value="Sec23/24_helical_dom"/>
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        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
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        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
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        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
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        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="353"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="598"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="691"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="821"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX04758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="959" mass="104578" checksum="BA58C5E882C75BFD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU80</accession>
    <name>U4KU80_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU80"/>
    <dbReference type="OrthoDB" id="5336297at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="420" mass="47465" checksum="230B1139995377BE" modified="2013-12-11" version="1">MMRSDSDKSQGSPRGGSDSWHNGGRGSEATTHSATIGLNPLPASPPARYRTQQHHDADHPGASNTEVSLWGRRRGPLGTVQQTPPYPPPQPPHPAHPAHQACLEHQAAPRDDFVFGAFGAALAARIHFPPHRTEPSSNKKTRGRAASQPKHGDNPRVQQRRVTDGTPKLRQISNGSNRSRPIGKPALPPDQPLLDVPMAEGTEPDMLFEAYRDSREFSQRAKDYWLQVGSLHHMFDVFDWWFYRVVDRLERKEYSKIELDPHEKMLQRLIAEESAADKGLPDRDGPGFGLINYFADHMVPKYGFTVEQVETARNDPTRWERRNAREEKWNDASDGPEQQESWRTKHIEAARKKWEAKMRAASNPKPKQKRGNQTNLAKREKGPKGSIITKARFDTRNRIGKKGGNAAASRNFNNRKLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUD9</accession>
    <name>U4KUD9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat domain-containing protein 36B acc. no. Q8N2N9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUD9"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19740" checksum="664F15E22EA52E84" modified="2013-12-11" version="1">MEIVRLLLKRKEVKVNDIPNATNEGMPLILSMARYSKEESMRLLLERSDIDVNARHYIDQSTALINAIQCGQENIVRILLERKDIDIHARDCYGRTALSMAHERGHYSIVDILKSRIQYEKAGIDTDSRKNLPLPSSSPTVPEEIDATEGQASQGQRKTKRRKNSWPGTERVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUN7</accession>
    <name>U4KUN7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUN7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="187" mass="21386" checksum="7EE16D3ADA7019BA" modified="2013-12-11" version="1">MGAVRLLMQPPFPYPDKKAEEMREHLDMLPCFFGPGDGDRVLKGLRNAAGVVLNDKAWRDSIPLREHLQRVQMLANRRCNSASEIFVMDCFRECKAILQCLIAVFDEDPDQAISVMQLRDHTEYFFLLMVVANSEGFAAHRKEIVDIIEKYAKKLFEEVDATDGVPVMDTKFNEKDWSTAFLPNNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV38</accession>
    <name>U4KV38_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV38"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="10082" checksum="E0F82A3C26951B70" modified="2013-12-11" version="1">MGGWNVGRSRSSPELQGRRRIAIKRIVGCRGLMRTCILITTRFSENDIASSVHTACTQSALTISPDLLVGEQLSFSCCMSLCHGAVMVLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV92</accession>
    <name>U4KV92_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_03793</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV92"/>
    <dbReference type="STRING" id="1076935.U4KV92"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="14">
        <location>
            <begin position="74"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="15">
        <location>
            <begin position="463"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX04811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="652" mass="71067" checksum="5029385FFFF28D8D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVF9</accession>
    <name>U4KVF9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Putative serine protease K12H4.7 acc. no. P34528</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_05130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935259">
        <property type="protein sequence ID" value="CCX05543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVF9"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YHVNDAY"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650882" evidence="6">
        <location>
            <begin position="20"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX05543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="558" mass="62524" checksum="CDA4C3C78BBB283A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX14</accession>
    <name>U4KX14_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX14"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="14163" checksum="827C7C529351CA6F" modified="2013-12-11" version="1">MQAYPGDLMTFINLRERKADYLGLEWSTRTTFDPDSEGYICGTCDDSNEWTSNNQSERRKQIRDHGCMIKPNAADLAWVYDNNGRICKSIRESSWTEINEEKAAMKDEFGPEGDQRSRWVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX73</accession>
    <name>U4KX73_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_05968</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="HF935287">
        <property type="protein sequence ID" value="CCX06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX73"/>
    <dbReference type="STRING" id="1076935.U4KX73"/>
    <dbReference type="eggNOG" id="ENOG502QSPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHLDAWM"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="18">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="124"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="572"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1272" mass="138769" checksum="ED142439431398CB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXD4</accession>
    <name>U4KXD4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Peroxisomal membrane protein PMP47A acc. no. P21245</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_06053</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXD4"/>
    <dbReference type="STRING" id="1076935.U4KXD4"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000134">
        <property type="entry name" value="Peroxisomal membrane protein PMP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
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            <end position="241"/>
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            <begin position="2"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="320" mass="34618" checksum="EE4281E567A49B43" modified="2013-12-11" version="1">MSDNVLHAVAGAGGGVLSMILTYPLITLSTRSQVESKRAKTTVLDATRHIIQREGFGGLYAGLDSAVFGISVTNFVYYYWYEWSRTAFETAATKSGRNSKLTTLESMIAGAIAGSATVLITNPIWVVNTRMTARKRDSPAPIPGSPSSDKPTLTHPTGPKKAPTTFGEIKALFEEGGLKAFFAGVMPALVLVINPILQYTIFEQLKNILERKKKRNLTPTDAFWLGAIGKLVATGLTYPYITVKSRMHVGGAGAGEGGIFGSLRRIVKGEGWQGLYKGIGPKLMQSVITAAFLFAFKDAIFNVAKKTLQDRRRLLKAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXQ6</accession>
    <name>U4KXQ6_PYROM</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935302">
        <property type="protein sequence ID" value="CCX06616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX06616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5127" checksum="D419750A64E2C25D" modified="2013-12-11" version="1">MKLGFTGYANPENFALLLNRPLHTSVAPSPSLPLAPLPFLLSSEPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXX4</accession>
    <name>U4KXX4_PYROM</name>
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        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_06619</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
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        <reaction evidence="15 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
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        </reaction>
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    <comment type="subcellular location">
        <subcellularLocation>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="234"/>
        </location>
    </feature>
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            <end position="52"/>
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        <location>
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    </feature>
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        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX07032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="999" mass="112265" checksum="58B5B1BC9420ECFD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY91</accession>
    <name>U4KY91_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_06528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY91"/>
    <dbReference type="STRING" id="1076935.U4KY91"/>
    <dbReference type="OMA" id="TWIAACI"/>
    <dbReference type="OrthoDB" id="5301470at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="266" mass="30264" checksum="E442FE99AF4AF946" modified="2013-12-11" version="1">MAVMDPTGGLRDIRSLNTAYAPIPRDPECQDEDWNTQSHRGALPLPVMSQKVSYTKQKALHRSRLVFRIISLVASGTALGSFGDVVWSYMKTRDARSHHGNEKIWPDDIAHFSCVYMMISAAVITFVVDFGWFVASIKPEVRQLQGNMLKAICGAVEAVCLALMITGVAFLEKAQRDKKEKWLGWVCEAKTLHSDEASKVDFPFLCGEVKAARVAMYMTLAVQVILVLTVIIDFFYRPGYSKFVLSKEYRMRQPWEKFLNLFRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYE9</accession>
    <name>U4KYE9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYE9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14148" checksum="3E8D504763362BD1" modified="2013-12-11" version="1">MSQPTVYSEAALFLDPPFYCIWTLTADGRRGKLITGPEPSATGLPSQELPELEPFVFATVADANQAAQGIFEECTGNKIEPQNVQTDPQTGFKTFTNPAAESGDEDFQLILKMWVDLEDGYGAKSLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYY5</accession>
    <name>U4KYY5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935320">
        <property type="protein sequence ID" value="CCX06895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYY5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="357" mass="42030" checksum="536D83BA5D836822" modified="2013-12-11" version="1">MNPASMEEQASTMGVSTVREESDLIFSDDKRDDTERNTDGRDNQWTDTYEDDFHNDDIDSQDEDTHGDDSVDNDFLHDNFRRGITSCLDTLLSNTCRSSARLRVGISDDSNSAQLLEVKKQAKHESYEENKDSKEHEEREEEGGDEEEDEDEEEDGDEEEEEDEEDEEDEDEDDADEEDDEDEEGDEDEEGDEADSYEENTMSQTHNMHNIANFRLSYDPKGPYDTYDENGDRERMYLDEVERSYYKDLPDCETEEELHKAIFMREFEIWCEENDIEVSNRYSQWLSTRQQDRVFVPRMLWEMNFLEQDLYEPVSTECTGKGKFCCLMHERALKALYTQVDPSRRFFASDCKGPTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZJ4</accession>
    <name>U4KZJ4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRF2-interacting telomeric protein/Rap1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZJ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="13117" checksum="128A8131AD176964" modified="2013-12-11" version="1">MLRRKYPTLTDLRFWWAVEKTGNDRDLTLEVVKEWMEHKRLLEHPRVWTMADDLVIRGNDVRAIEEVIKRRGEEEWERRMKWVNMKAEIRADREAEKQLQNGSGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZN5</accession>
    <name>U4KZN5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZN5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3402" checksum="86200D83D098DE5B" modified="2013-12-11" version="1">MGPPNPNLQPQPRKALESLVANPSAFLIQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L057</accession>
    <name>U4L057_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L057"/>
    <dbReference type="STRING" id="1076935.U4L057"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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        <source>
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</entry>
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</entry>
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        <source>
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<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Kumar A."/>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935543">
        <property type="protein sequence ID" value="CCX10455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L325"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="34058" checksum="1303A65BA9149F53" modified="2013-12-11" version="1">MSGHQRNLSDASIGSFQMVDGFESDDEGDNIINRPIGNHEVKVGDECTITIKNTSLRNHLTDTGRIILVDTHRMFRDEAIYLFLRIMMHNNKKTGVAVIGAALYEDQLKDTSINVNGFDFLARLKDALANKELLKQELVYIPIRWKMFSDKSIVYFLAIIHGLNKISTNAPRVFLLRPCSSTTVTQATKSCYKDLIRPAIVGLAGLENSGENAIVEHQVQCDGGDEGFYWDQSWYYMCCFLIHTYNNENIAELLDRFEQNKDLNNLWSQWNPRAYYTKVFNMIHNSIEEPKENEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L336</accession>
    <name>U4L336_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Kinetochore protein Nuf2 acc. no. Q7ZW63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L336"/>
    <dbReference type="STRING" id="1076935.U4L336"/>
    <dbReference type="eggNOG" id="ENOG502S6DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="758"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="892" mass="98917" checksum="0AED532159ABC5EB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L397</accession>
    <name>U4L397_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HF935207">
        <property type="protein sequence ID" value="CCX04520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L397"/>
    <dbReference type="STRING" id="1076935.U4L397"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX04520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="624" mass="69986" checksum="E57EA196812357FD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3B9</accession>
    <name>U4L3B9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized HAD-hydrolase MTH_209 acc. no. O26311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935315">
        <property type="protein sequence ID" value="CCX06808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3B9"/>
    <dbReference type="eggNOG" id="ENOG502S0RM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCWIERR"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="25039" checksum="80E10D1FFC4E8341" modified="2013-12-11" version="1">MTTPRLTDQKALIFDVYGTLIDWETGLHSAAPLQPRTTFLQTYLDHESALQTANPTMLYSTLVSEVFSKLSLPAPPISSWPAFPDTAAALQILKKHFKLIVLSNVDKASFATSLPRLGGDGVFDLVVTAEDVGAYKPDLKGFEWVLKEVKERWGIEKEQVMSVANSLFHDHIPAKKLGLKGVWIRRPGAVMGVEGMDMTTKREWEYDTLGEMAESVEREVTDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3G0</accession>
    <name>U4L3G0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Zinc-type alcohol dehydrogenase-like protein PB24D3.08c acc. no. Q9C0Y6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX10566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L3G0"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPIKNIH"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="388" mass="42044" checksum="52D3F0CB7744EB95" modified="2013-12-11" version="1">MGVYICPPRSLIFESQNSITFQLHSLQKHSLHCTPLSKMVQNKSLIFSSIPHGYPVPGKDLTVKEAELDLNSVPEGGVITKNLFVSFDPYQRGRMRDASIKSYAPAFELGSVVSNNGVAEIIKSSNPDFPVGQIVVGYLGSENYSVIPKEYLGGFSKIDNKYNLPLSNYTSALGMPGLTAYSSLYKIGKPKKGETIFISAASGAVGQIVGQLCKREGLTVIGSVGSDEKVAFAKNELKFDEVFNYKTISNAEALKKLALNGIDIYYDNVGGEALEAALEAANQGARFIECGMISAYNAKSKDELYLPGNLMNIISKRLTLQGFIVGDPEFGPAYAEEHRENVSKWLANGEIIIKESISEGVENAAEGFVGMLQGKNFGKAVLKLVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L432</accession>
    <name>U4L432_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L432"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3865" checksum="62D56315AD8C4074" modified="2013-12-11" version="1">MHRSCLYLSALPDLTNLERCFVRDGTFGSARMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L637</accession>
    <name>U4L637_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L637"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7122" checksum="1C7F71FAB2FD1615" modified="2013-12-11" version="1">MRVSMPGTLETRNLPSSRQQLESRASSSRCCIHKECSAGRLIESISCDANLCAPKYRRHSSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6N1</accession>
    <name>U4L6N1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to mRNA decapping complex subunit 2 acc. no. O13828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935403">
        <property type="protein sequence ID" value="CCX08250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6N1"/>
    <dbReference type="STRING" id="1076935.U4L6N1"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DMKYIEV"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="112"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX08250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="845" mass="92451" checksum="2565F32DBCB42AF6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6S4</accession>
    <name>U4L6S4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6S4"/>
    <dbReference type="OrthoDB" id="10325434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="26794" checksum="8CE96DC0621F8FE2" modified="2013-12-11" version="1">MSVMSPADYHKRFAGSQRQNAPSPLHLAITPTTNRYPSVGYDDDRALSPCASSVGENTYFLDSGTGRPVRNVTSVHIDGLMRQRSGRSYYDQHGNYSTPYRPSGQFNAYESFAAHERRRESAISYAAQNVFHGRAGTLGSQSDESDYTDVTDYTARPKISDREMYEWLRMYQLQRIRNFVEKQPARVVEEREKNVEALVKTTTYHKLMFAVVGVGVGLLIVVIVLSIKALVSPGKGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6X3</accession>
    <name>U4L6X3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative helicase mov-10-B.1 acc. no. Q1LXK4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6X3"/>
    <dbReference type="STRING" id="1076935.U4L6X3"/>
    <dbReference type="eggNOG" id="KOG1804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LYYFDEC"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="362"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="647"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="996" mass="111368" checksum="147CC1BCEC887E89" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6Z3</accession>
    <name>U4L6Z3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6Z3"/>
    <dbReference type="STRING" id="1076935.U4L6Z3"/>
    <dbReference type="eggNOG" id="ENOG502STBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="154"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="39593" checksum="BF5B816CB6565779" modified="2013-12-11" version="1">MQLPAEEVRTDLQKQADTSSSVAEAIQLGLELQLKMEVTGLPTGELKAARKKQADTFRSVAEAILLGLEALSKMEVTELPTEELKASMKKQADTFRSVAEAIQLRLETQSKMEITVQNMEGGLNAQEMHELLRWISPLEPQARHQDIRSKRLRDTGNCFLETEDSREWCDGDGHKGHNVFRCYGIPGSGKTVMSSLVIDHLSSRFSGMNVIIAFFYFDYQNQRYKSAPQIINVLPRQAIYSLKDNQEVFDNISRDLLAKKANAEDLSLEYSIRSLSKVLEGFDRVYLCLDALDECQDEHRRQLIQSLKDLAVKAKIFFDWTVLCRSYGTKIFRPFSFAISHSTRSEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L720</accession>
    <name>U4L720_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein YMR178W acc. no. Q03219</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935693">
        <property type="protein sequence ID" value="CCX12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L720"/>
    <dbReference type="STRING" id="1076935.U4L720"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="38"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="344" mass="38521" checksum="C8625DA96C2DA0E8" modified="2013-12-11" version="1">MFSIPRLSLVSRHITTPTFRHVSKMSGDLFKKTLRTAACIIIGDEILSGKTVDTNSSYFAKYCFDLGIDLKRIEVIADDESEIIEAARRLSAKHDFVITSGGIGPTHDDITYASLAAAFDSPLEMHQETRDRMKRITMARPNAPPFDWDTPNPALTARMRMATLPSGEGTKVVFVSDDLWVPIAIVNYNIHVLPGIPRIFVQLLEGLREIIIKEGRVDKSQKSIRVLISTPLVESEVAEYLTKLQERVAPRGVKIGSYPRWGMKRNTITMVGSDVEFIESLVAEVERETQGTRVTEEDMADEPGQDKTEEALKNREAQNKGGMEAKERKLNEAVHGSRVQHSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7U3</accession>
    <name>U4L7U3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_05791</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7U3"/>
    <dbReference type="STRING" id="1076935.U4L7U3"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="36"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX06204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="369" mass="40024" checksum="7BEC86175A0B327D" modified="2013-12-11" version="1">MSMFRQSIRRFATAADSASPYGIRVGKVQGTVNGFTGAIGNTPLIRLNKISDETGCEIYGKAEFMNPGGSVKDRAALYVIKDAEERGLIQPGGTIVEGTAGNTGIGLAHVCRSKGYKCVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFENPENYNHQAKRHAERLENAVWTNQFDNTANRRAHIETTGPEMWAQTGGKIDAFTCSTGTGGTFAGITRYLKEVSDGRTEAWLADPPGSVLHSYIQSGGKLTERSGSSITEGIGQGRVTDNLKQEINLITSSFTIPDEETIHMVYRLLDEEGLYMGASSALNVAAAYQLAKNIGPGRTVATILCDGAYRYADRLFSKSWLRQKGLDKAIPSHLEKYAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7X8</accession>
    <name>U4L7X8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Putative ankyrin repeat protein MM_0045 acc. no. Q8Q0U0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L7X8"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="4">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="5">
        <location>
            <begin position="433"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="660"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="6">
        <location>
            <begin position="914"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1384" mass="154315" checksum="881EE974B82B3F61" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Q0</accession>
    <name>U4L8Q0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to UPF0303 protein YBR137W acc. no. P38276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Q0"/>
    <dbReference type="STRING" id="1076935.U4L8Q0"/>
    <dbReference type="eggNOG" id="ENOG502S03S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMQEDHE"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="16815" checksum="9357E760CB81A710" modified="2013-12-11" version="1">MAAPALVTLPHFTVTDAWSLGSHIRTLVNTSFPDRGVSIRIVTASNQIIFSTVTSPGSSPDAETWLKRKINTVLRYGVSSWAVGESMRAAGLPGKKLSEKVPGVDDGEYAVHGGAVPVCVEGVYGVVAVVAVSGLKQEEDHQAAVDGLRWLKEQAGEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L920</accession>
    <name>U4L920_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L920"/>
    <dbReference type="eggNOG" id="ENOG502SG78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8405" checksum="54BE887DFDFC843C" modified="2013-12-11" version="1">MGFLDKLQQKFELYKLEQKYTKRKRRTTFISDATYVDGEYVYYSQGEKPPTASDRSGFRVSSFATGSTTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L941</accession>
    <name>U4L941_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX10041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L941"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6907" checksum="3D4E887866FF1F75" modified="2013-12-11" version="1">MTLGMHRSITWIDEPSCVLLSLLPPWAFELLHVSDHYFDSQTGFLYGRRDTYDEKNMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9W0</accession>
    <name>U4L9W0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936188">
        <property type="protein sequence ID" value="CCX15519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9W0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="488" mass="52931" checksum="0B23EC1F75E78649" modified="2013-12-11" version="1">MSTDHSSLPDVRTDSSPPISPLENSARVAFTPHKKLPTPSPTKGPTISITHKDTEPPRFVTVVKTPRSSSIGIQSSLSSSRSAPSPVPALPLLSNGNSMKDPQDQQQIPQGPTGHPFLFVPPENYYRMERPRPIKQVSHGPCHGYHTLRGQPVLQLPELPQIPNTPVFAGTGFGEGSEGRSPLLGLLGPPRSAGQDSGWGSEVLHSDIDIDITPPGSGGPKDIELQSYPEHGIAGNRYPHTGDSTDGSRHPNSPHARAERQLSLASLLIATVQDQRQPDHFHGSFLSPYSPHQPSLVPLNSPLSAEDTTSGQRIFRSIIKTATPSSIRKPSSGSLSSSSGTSSAITRCPFISSHLHLSTHTNHLSTHLLSSLNQLRNEITIMTPASAQRYAAFNRLGQYKQDLIKLETNILHVKGSFETLITENRLLGLPGGVKRTMEINLQVLEDEGREARRVWELVRGEWEEMAAGGARSGGWWGWWPGRECCGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA61</accession>
    <name>U4LA61_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA61"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5159" checksum="64C76E2A4224282E" modified="2013-12-11" version="1">MRDARRSHPGNKRRPEAPHLSGCGSGDQMPTRGTLLITNSGDDSVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA93</accession>
    <name>U4LA93_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cell division control protein 73 acc. no. Q9UUE7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA93"/>
    <dbReference type="STRING" id="1076935.U4LA93"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRPDYWN"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="217"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="42594" checksum="295B50F81AB49BD9" modified="2013-12-11" version="1">MSDPDSLLLLRASVLANDPPSLTPTESLDTAHSLLFPPLPPQYPAATTIPLNTLTRFIKDNAAVDLRSIYFAWQQREATITEYLANAQSLGVTHLGFMERLELVTYLEGGQEEGEGCIRPIEKTQASTAAGSAGASKAQTSLVGKVRQTDPRLTDIYNAERVIMNRNVMLRGIKPTDFSHVRKQSEDFITRLRNANKPSTSNLPTRPSRPPPPSSRRRDPIILLSPSASSLLTMSNIKPFLEEGTFVPATSGSDHPNFLRVSRLLPNIHPTTPIRFDVVDSPDKFKPDYWEKVVAVFTTGQEWQFRSYKWSNPVELFRETRGFYVGYEGEQVPELVMRWGTGVSVLKVERGRRFRDREVCEKFWEGVEGWMKGKGWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAI8</accession>
    <name>U4LAI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAI8"/>
    <dbReference type="STRING" id="1076935.U4LAI8"/>
    <dbReference type="eggNOG" id="ENOG502RZ8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="372" mass="40574" checksum="75D2F0DE9472CB16" modified="2013-12-11" version="1">MDHSPTDRRFGGLGRQGNYLPLEDFGSLPSSTPAPQETAEEFTSPSPSLASPRDLDEPGCFLVPPSDLDCRLAWKWEILSLVVSGLAIIATGIFCFIIGGTNQPAWSTSVYGLSLNAILSTFSLASKSGILFPLDEALGQLMWLAYADGKWPLADTELYNHASRGPWGAVQLLSKRGHRGITSLGGILMILSVALAVTQQQLINYRTHIDNTVDDPLNLTLVATSGHIYDSVQQASDEKDGPIQPVVEFAVSAEVFSSLNHYVVHDPLYRCDSGNCQYPVFTTLGICSDCSMNRTANYACDGDNDMCEAEYDGLTSISYKENSGDVEYRSTIVNQTAKMDDPDLSIIVRTWTLSVNDTIWPPAYKAYTCSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAX9</accession>
    <name>U4LAX9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Nitrosoguanidine resistance protein SNG1 acc. no. P46950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAX9"/>
    <dbReference type="STRING" id="1076935.U4LAX9"/>
    <dbReference type="eggNOG" id="ENOG502S0DZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MCYLYAT"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="50"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX16286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="434" mass="48683" checksum="0EAF4B20D41D14BB" modified="2013-12-11" version="1">MDTPREIPLPRENESQDTLHQEKTVERHPPPPKTPPRRKLLKIILIGAVQLLILFWFVSSWMLGKMYKQSQYAHRLHVIAIDLDGGPIGASVLDTVTGLNGQPGMPTWERIPYGSGETFEDIYHKVWTGDNNIWGAIVANPGASDRLQEAITSRNASYDPTQALRLVYNEARYHTVTVSLIYSNLVAAVSQISAHYQLTTGVNGLSSLPANATAANKAAFLLPIGFTLSNIQPFAFSATYLINTVMFVFPQLSQFFMVMLLNGILGHAGAYINWSLKANLTVRFIIGTLWPFILGLSWAGWVFIFQTTGDLQTPQFFAIWSSIWLFAAICFWTIDGVGALIGVQWMPFFILSWIIVQIATVISPMQLASHFYRVDYFFPSHHIWGILMTIFAHGAGNNLKINLPVSFAWLIIAVAFGTWANTRRWKKAQKLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB48</accession>
    <name>U4LB48_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936498">
        <property type="protein sequence ID" value="CCX16673.1"/>
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        </source>
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            <dbReference type="PROSITE" id="PS51821"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CCX16673.1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="575" mass="64344" checksum="87C8BDADA4ED67DD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBT9</accession>
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        </submittedName>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX16692.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="38187" checksum="3180773417EC8A24" modified="2013-12-11" version="1">MTTEDVKMTIAEEPVAVATDAPASPKAEVVGRVRNSKFDASLLPESTDPAEMRKQVEFYFSDSNLPFDKFLWSMVTKDNKPVPVKLIASFGRMKRFRDHAAIVAALRESSVLDIAGDEGDETVVRKNAYVIAEKGAEPKELIKKVADKTLKFSMYAKGFGEETPTTQIDVEKMMEPFGPINSVRLRREDNRVFKSSVFIEFASEELLQKFAALEEKPTWNGEPLIWKTKAEYVAEKADLIARGVLQPSVKKTKNFNAHREESGNSQNKGRGGRDNKGGRGGRGGRGGRGGRGGRGGRGGRRDRDGGRDNNGGRDSNGIPVLQNANDEPQGTKRKAEGGDDREAKKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCD6</accession>
    <name>U4LCD6_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein YGR111W acc. no. P53265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCD6"/>
    <dbReference type="STRING" id="1076935.U4LCD6"/>
    <dbReference type="eggNOG" id="ENOG502RZ3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCWILVD"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="2">
        <location>
            <begin position="171"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="401" mass="45188" checksum="73FFD6A0FE42C945" modified="2013-12-11" version="1">MTDSHLILRLATPTESRYIRDQNAASWAGDLPVETYHKREHVLASTALTRDGGIECWVLIDPSKPSEVLTSCETIKKPAYLSRPPDNGDKICNVVEVYAHGLGSVYTPECQRKKGYCQEMLRLIKEHMMKENPEGFNVLYSDIGKQFYAKHGWLPHRSSHLQFPSVGPVPESTMTGITPLVRASIPALCAQDIALVKSHLLTPPSHKKSRIAFIPDYNTMDWHWTREEFIAPVLRAHMNEAPEIKGAITKDGKRWVLWNRDFATKSSQLYIIRYVDLSKQPRESRESSALSQSPRSSLSSGSESSNSDNSDSESEQEDQEEQEQLSALLTAAAMEAKKWGLAKVTMWNPDKACVKAAQKAFGNEVKMVDREMDSIASVMMHKEGSDEESIEWVANEKYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCZ8</accession>
    <name>U4LCZ8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCZ8"/>
    <dbReference type="OrthoDB" id="10398737at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652155" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25467" checksum="A49CDB6205226C08" modified="2013-12-11" version="1">MRPSILFLAATLLQAVYAAPSSAAITPDLNTRDEPKIDTTPVVTLNELFTAIPGGRQAFAEALSSSGGAGSQGQGLSGLGGSPADTIDNLLSILHPILGPIMGLVRKPCQKIYESCKADAAKCLLGNRPPIICDGYDDTCEDFKLGICQGKISLQTLPDFPLIDLKKQCVWLVGKICKNDEGCKQRFKGVCGVLPGNLLPGLNPPNNGGNGGLLDGILGKNGILGGLFGKGGALERGGEGIEAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD29</accession>
    <name>U4LD29_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">PCON_04411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD29"/>
    <dbReference type="STRING" id="1076935.U4LD29"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="306"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX17407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1266" mass="139894" checksum="178659C377A0E541" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDA6</accession>
    <name>U4LDA6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Protein CFT1 acc. no. Q1E5B0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LDA6"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMTKFKL"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1415" mass="155086" checksum="82818EDAA587A387" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEG1</accession>
    <name>U4LEG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Oxysterol-binding protein homolog C2F12.05c acc. no. O14340</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LES7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8684" checksum="6C2A4093649E5F80" modified="2013-12-11" version="1">MGCLKADASTQSNPRDSWKLMSPHNPKDTFACRRAVEFSIIKIRELILGGLKNRRKHPSIGDTVGVIGHEVTTRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEW4</accession>
    <name>U4LEW4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_08597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEW4"/>
    <dbReference type="STRING" id="1076935.U4LEW4"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPCHELR"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="165"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX30398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1197" mass="133650" checksum="6C0088FD38C48E57" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFP9</accession>
    <name>U4LFP9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFP9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20508" checksum="A4941E4C3F3989C7" modified="2013-12-11" version="1">MISLSTLLYSNAKLWRQKSTNGQLQPHLNSFNPPQPPHLGTSTLGLSHLFNPQYYQAFDNFPSPAEADPVFTNNNYYYQYLTDQSHAAPIANTRPPNPAFDAAAFGSSHDDTGNDIVNASVVDPFADGPSASAVIEMWLVDSPQPIFRLGCSWSTSRSSSYSGLTDSEFTLDLRIFVSIGLWFIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG68</accession>
    <name>U4LG68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Molybdopterin synthase sulfur carrier subunit acc. no. B2WKU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG68"/>
    <dbReference type="STRING" id="1076935.U4LG68"/>
    <dbReference type="eggNOG" id="ENOG502S73M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYFSTAT"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="8873" checksum="3DA368079CFB0ADE" modified="2013-12-11" version="1">MAGNFKILYFAATTIYTGKDSESLSAPMKLGEMYELLEQKYPGIKGVIQGSMCTVNLDYVEDHELVIEAGDEVAIIPPVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGM6</accession>
    <name>U4LGM6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGM6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="9945" checksum="7FD850CD9CE9757C" modified="2013-12-11" version="1">MGTLAAVGLYKDSVHPDETVVVIHNEPGTSPGQHEERPTTIHSERPATGHSGNAAGTTGTEPVTDVPEGVIKASGTVVMVENEHGLPPGVREALNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH35</accession>
    <name>U4LH35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936252">
        <property type="protein sequence ID" value="CCX15729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH35"/>
    <dbReference type="OMA" id="LEDANCW"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045992">
        <property type="entry name" value="DUF5948"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19373">
        <property type="entry name" value="DUF5948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651367" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10380" checksum="35AF35CC9240E969" modified="2013-12-11" version="1">MVSPTILLIQLLLATTALAAENCMCRDYRGDMHSLTMHCCRNQKGYGALITMMYWPGPHKQCTSPFKKIDRVEFSKCCRMMGALEDANCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI93</accession>
    <name>U4LI93_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI93"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="14025" checksum="00512E5E911B66A4" modified="2013-12-11" version="1">MQAAFAELRSVSNVSAFADPATAPALTLDNTQPEDVDPGVQAALVDSYGTMVPDVSAAVIPRLDVSRLAELGLFLGSQGRTVAAATVVPLVMAANGVSAGAESQQEAPLPSENQEFWDGVSGAIEEKVPGLARTGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LII2</accession>
    <name>U4LII2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ABC1 family protein C21C3.03, mitochondrial acc. no. Q9P7M0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LII2"/>
    <dbReference type="STRING" id="1076935.U4LII2"/>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SMVRTHH"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="308"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="702" mass="77429" checksum="8D5D66542561A2CD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIK2</accession>
    <name>U4LIK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIK2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3795" checksum="DB8A64F9B23ECE9A" modified="2013-12-11" version="1">MGGRPISPSATWFVRIRKRTARKFLSGFNGVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIS2</accession>
    <name>U4LIS2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIS2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="346" mass="39817" checksum="6DA70D56F1FFCCE4" modified="2013-12-11" version="1">MTRKGGQRSHTKRNYDGESYSNSNYDKHIPCHCARPVCGISYESYEDLRAKHEAYEASKAQCEAHYQPKRYGEMYDKERHNRKSHGIKRYDRRGSDRKGYNGESYYGERCHGESYSNSSYYLQYNDAPYLTHLHYWNYAISYELAYLHYRNCAISYQLSYLSYPHHSNYRVGYVPSYPHHSNCGVGYAPSYPHHLNYGVGHVPSYSHHLNYGVSYDPYSAYSTHEAALGADPSPRSARPTLYLDPISYTYRAPPPGYRTRGHHSFGPTLACVPDEIIQELFPQSDEIMETLFPSPTPPSFQTPLSECKGTLACVPIEIIQELFPQSDEIMKTLFPPPTLPAEMMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJQ5</accession>
    <name>U4LJQ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935728">
        <property type="protein sequence ID" value="CCX32188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="8" mass="996" checksum="F7B32362C44B05B6" modified="2013-12-11" version="1">MSENVWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJT7</accession>
    <name>U4LJT7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Probable mannosyltransferase KTR4 acc. no. P38131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJT7"/>
    <dbReference type="STRING" id="1076935.U4LJT7"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="401" mass="46589" checksum="B3725FE7FDFD3B03" modified="2013-12-11" version="1">MVLLQPSGARAIFGVLLLTSFLLILYNFSSLSPAVTNIVHAGGNSKFHRPAKGGSLKGIDPLLEPEKGPGGKLWGPGERNRTSATLLSLVRNSELDGILQSMKDLEETWNHKFNYPWTFINDVEFTKEFKEKTQAMTKAECFYHTIPASDWDIPSWIDPELMSESADLLVENGVQYARMNSYHQMCRWNSGRFYHHPALQNYRWYWRVEPGVHFFCDIDYDVFRYMEDNDKSYGFVINIYDSPESIETLWPQTLEFLAEHPEYIHPNNAMGWLTDSKNRPEHNRKANGYSTCHFWSNFEIADMGFWRGEAYEAYFKHLDRAGGFFYERWGDAPVHSIGLGLFEDKDKIHWFRDIGYQHIPYFNCPSSPKCKNRCQAGRFTDGTGLDEEDCRANWFEMAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK17</accession>
    <name>U4LK17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ras GTPase-activating-like protein rng2 acc. no. O14188</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935775">
        <property type="protein sequence ID" value="CCX13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LK17"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGVLVHW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="217"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1777" mass="202998" checksum="03D96E5D918273E1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK39</accession>
    <name>U4LK39_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Trichodiene synthase acc. no. Q6A1B7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935806">
        <property type="protein sequence ID" value="CCX32288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK39"/>
    <dbReference type="eggNOG" id="ENOG502SQ3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFRRYSI"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="367" mass="41897" checksum="4518EA3BE594BFE5" modified="2013-12-11" version="1">MTRSLLTQFSSLVTALTPYPISKALTYLPTPYNVNKSTEYGRIKEEFNADIVFDFMKMMDYEIETPVYECPQALTDGVNNAIDAYGLDEKTKRGLLKAVVPAICVIHMPFRRYSIELKVFLTLYTALAIYIDNVIAVHPEIMVPELRKLPARWGLGLAENNYKDPIIGIFMRHVTLETPKHYGPYATGVIVKGSIDYLIGCLLEAELPKKMQVPKAAGRWTTFFRGKTGMGELYSHFLFPLEQFSEPEDVRYYIASIPDIAEIINKINDILSFYKESVVGDEDYNYVCLEARRTGQTPVEILRESCDEQVRLVKEIKEALSAHDLCHEAFSEFVVGYIMYHCTNSRYRLSEIGVILGPQDSDEDDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK70</accession>
    <name>U4LK70_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">PCON_13339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK70"/>
    <dbReference type="STRING" id="1076935.U4LK70"/>
    <dbReference type="eggNOG" id="ENOG502SCD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPLEDKI"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="288" mass="32101" checksum="8FE7A2C47C618E8A" modified="2013-12-11" version="1">MLPASISVARAPHHPHQLTMYTTVQKALDNLDEHLAKVIESVSSYNPSRATVAALVQADDELQATLAELEEHQQNYHRTIELQQTSDALDDKLTDLLTILAETRQHLIDTPSTKFPTPPKEVEYNQLLQFARNISKYSKPPNPLSFEKWAREQVLPPPPPPQSEGEAKPEEPVKTKLPLGINEEDLLHMDNSGALPYAPWPHEFMMKTGALAALGKDGIPVDMIPKEDKPQEEDKGDQARKDSTSNGGMDDAEKARRSSYQQQQHAAPKPAAPKNFSLDLWPGDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKQ4</accession>
    <name>U4LKQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKQ4"/>
    <dbReference type="eggNOG" id="ENOG502QS15">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TERDPWL"/>
    <dbReference type="OrthoDB" id="5312133at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="579" mass="64898" checksum="0FFEF0EC369B2080" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL80</accession>
    <name>U4LL80_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL80"/>
    <dbReference type="STRING" id="1076935.U4LL80"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFYPNNP"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="263"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="390" mass="44688" checksum="6B6450C30E016BAD" modified="2013-12-11" version="1">MSSEPPTAKPPLPRTKRPNYALLHANLLPLTIQALPPLIPHNPLSILQILYTYFFCRVPCQPEPLYTGVFNPTTRSVHVTDTRSIKAFWTSGFFGKGSLSRSEPTWISRRRRALGVIGKDEALTAEEVTERRRKERKEFKLERARAEKEKIQNQLAQEGKVQFETGAVAPSSENKSVTFAPPETPAEEKDQPAPQVVEVEDLEHLQLTLEEAFFLSYGLGALQIMNAEGNKPIEVPDALSLFRKFSYFPHLEDDAILQPDDVFLMNYVVYHHFRSLGWVVRPGMKFSVDYLLYNRGPVFSHAEFGILILPAYSNPYWAADPERKKRESRPWHWLHSVNRVSAQVKKTLIMVYVEVPPPHEIEGLGITDMLKKYGVREVSLRRFLVARNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLK5</accession>
    <name>U4LLK5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLK5"/>
    <dbReference type="STRING" id="1076935.U4LLK5"/>
    <dbReference type="eggNOG" id="KOG1876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EAYLGEF"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="169" mass="19559" checksum="932C9927D5D3100C" modified="2013-12-11" version="1">MSSSLRPYLTCVRSSLTAAMSLCDFASEVAERHNVPEIESGKTPEVLLNPITIARNEHERVLIEPSINSIRISIKIKQADDNEILLVHKFTRFLSQRAEQFVILRRKPVKGYDISFLITNFHTEQMLKHKLVDFIIEFMKDVDKDISEMKLFINTRARFVAEAFLTSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLS6</accession>
    <name>U4LLS6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLS6"/>
    <dbReference type="STRING" id="1076935.U4LLS6"/>
    <dbReference type="eggNOG" id="ENOG502QTDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NPHWCHG"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029038421" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX14328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="312" mass="34028" checksum="65F84E1C478EBF18" modified="2013-12-11" version="1">MWSLRTIIATASFITYAAAAQLTQITENFGPNPNGSGFYIYVPDKLRVPAPVVVAVHYCTGTGPAYYQNTKYARDADTKGYIVIYPSASAPGGCWDVASPATLKHLGGGDSLAIHSMVQWTLNKYNTDRNQVFVTGTSSGAMMTNVLLGAYPDVFAAGSAYAGVPFGCFAGPTAWNSQCATGQIIKTPQQWGDLVRAAYPGYNGKRPRMQLFHGDKDETLYFPNFGEETKQWTNVLGLSQTPTITQQNTPRATWIKRIYGAGQVETIQETGQTHNLVIMEDETLRFFGLDKLPLLSVSAEHGKLNIDVNIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMG6</accession>
    <name>U4LMG6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to kinesin, putative [Talaromyces stipitatus ATCC 10500] acc. no. XP_002485772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMG6"/>
    <dbReference type="STRING" id="1076935.U4LMG6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="21085" checksum="0898EAAD5909ECA4" modified="2013-12-11" version="1">MYEEAEKVLKDNLEDRKRVLGEVYRTFKVAQNLGFALLQQEKLEEAEDFFRYALEGQERVLRAGRLQTNRSAFLLGVSLQTQKRSYEAEPHLRRALVVMKGLNGDEESEVLACVSWLRKSVRSQKEESELGFCQRYPYFNGIKPNRRDRMNIYNSLKKAGIIDAAKLDIEGNTLGAVGFGFGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMJ2</accession>
    <name>U4LMJ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMJ2"/>
    <dbReference type="eggNOG" id="ENOG502S5UU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="73"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="20896" checksum="E0D1D4AFB8979C4E" modified="2013-12-11" version="1">MAPSKKEKSQTVAAEAPVDAPVSPVDAKKDATDAKKHRRGSSSVTDILKPEELKAFLGEEKDLIVAKEVAKLNWKMNTSPATLEEAKAMKELPITTPKVRKLHIFFGTGIHVTARASPSSKTGVTVYDCLTAIHKLYKKKADDELELPVLADIEWGRGQDLKNASEEWPAVVLVTQKKEQAPTNKKKTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMX9</accession>
    <name>U4LMX9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMX9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7946" checksum="FDE71BCA9F23FE08" modified="2013-12-11" version="1">MSQFGFLEFSVAALRAQTWRWMNVILGRMKDVAWWGFVGLPRWRWRIIPHAQCVRIASEHSPVVIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN27</accession>
    <name>U4LN27_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C757.02c acc. no. O74913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936252">
        <property type="protein sequence ID" value="CCX15730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN27"/>
    <dbReference type="STRING" id="1076935.U4LN27"/>
    <dbReference type="eggNOG" id="ENOG502RI8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISGWSLM"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF8">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="4"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="386" mass="43416" checksum="E4E370F9AA833E66" modified="2013-12-11" version="1">MPTALIFGASGISGWGLLKYCLTDPTPDYWTRIIGLTNRPMTLEAAALPNDPRYQLAHGIDLLAGADAVTEKLKGVEGIEEVETVFFCAYISNSDYHELSRINVALLRAATIAVDTLCPNLKSITLQSGSKYYGTEFAAQTPVSPPPLVETMPRVPSPFSEKIFYYHQYDLLKELSTGKNWTFYDIRPDVVVGFVPQGNCMNLAGTLGMFLSLYRYVEGEGAEVVFPGTEKSWSNTHTDTSQDVLSRFEILVATSEKAEPQGSYNIADGDKTTWAEKWPLICSWFGLKGVAPPQGAKDTQSKAFREWWDQNRERYQEMKKEFGLKEQEPNDEAWGFQEMIMCGFEVDREYGLEKAASVGWTEKRGHEHGYWMAFEMMRAAGFVPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN73</accession>
    <name>U4LN73_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN73"/>
    <dbReference type="eggNOG" id="ENOG502RYJ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651753" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="207" mass="23263" checksum="3A8DCD2BB63EA83E" modified="2013-12-11" version="1">MKFAIILSALLASVLAAPVEGDVESQTDHHPTHPTHPQKPEMVLFPNYLVPIKEAHPDHAHETQKTGMVHWESHTHGEEIRLLVGFDIPEDVGPKCMINFSLPPQQKYGYQWTVNGSGKLDVWGLKSMIINGETSWNTKPMRTSWKPMYTIHQPKNGGMAKVTGKWVPCKAGERMDFEVAGARAGPVFFDWYELDNPKTGITMNVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNE5</accession>
    <name>U4LNE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNE5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5488" checksum="D0E0E481040C2E08" modified="2013-12-11" version="1">MPPVAGISPSGISAIGFIVRRYDYRQRRAQKRSITKQCLHYVFLPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP36</accession>
    <name>U4LP36_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Ankyrin repeat domain-containing protein 17 acc. no. Q99NH0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP36"/>
    <dbReference type="OrthoDB" id="7729168at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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            <taxon>Pyronema</taxon>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </reference>
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                <person name="Kumar A."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="6">CBS 100304</strain>
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    </dbReference>
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        <location>
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            <end position="189"/>
        </location>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34441.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR01</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRH4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14788" checksum="609802C743DF3779" modified="2013-12-11" version="1">MFERYANACWYPGSGWACVRQHLLTTLYSSLRPSLVMLGGARTTTHICGGVASADIRAFLSIIWDPIGKFATSIDYPNARTRASCDIDIDLTAGMIHCVRSAKNRGTSGRPKMQRLCIRTCAISWLSASNDGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRN5</accession>
    <name>U4LRN5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX31995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRN5"/>
    <dbReference type="STRING" id="1076935.U4LRN5"/>
    <dbReference type="eggNOG" id="ENOG502SRCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TICHTAM"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="33951" checksum="50157740C0D8C773" modified="2013-12-11" version="1">MASSGSLHRQQRADAIREVKTILAEVRTDWTYTPPTPRRPPQPLTRNASTRSGVLGAWRPTAESFADEPEPEDSWDEAWASTDESSDDDDELSDTPRDTLQRSRSYRRPKTPPNQLPKRKRKRKINRDNGEWRRRVEDSDFEIPEGDPLEVGEFEGYEIVKEKPTMKDWNEAPPSPRRKRRRYERALIKSNPGLRTWWRRRDQWTGADAEGYVPVGRSKFEGSVLSQMVEPGHYMEIYQKCVVRGNELPVPINLKNMIEALVVGWKSDDLWPPKPTEPQGSMGGRVKRYLGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRU6</accession>
    <name>U4LRU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRU6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651856" evidence="2">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="150" mass="16303" checksum="175934441B9F350C" modified="2013-12-11" version="1">MAKLSRSVQLLAVFPFIAIMLHVHGELFVTHPQPLETIEATVIEDSTIGASAHPLHAPDGYLLKTPDSSSYSEDSPNSNHPFVTIPDSPITNPEVSALTPRDAHDYPPEESLDYPTFFDPFSIHLPPPVDTPPYPDPPKVSSGSIPNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSD6</accession>
    <name>U4LSD6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSD6"/>
    <dbReference type="STRING" id="1076935.U4LSD6"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="15634" checksum="F6B7935A6A620DED" modified="2013-12-11" version="1">MALVHLAGLEDTVRVIIGSSTDTIKWCTTKGTWGTAGADFVFLDHLKPMYTPDLRLMESLGVVRMGTVIAADNMVKPGNPPYHEWVNADKNKKEEIVKSIKGEEKGKTGIRYENTWIESWELQAVPDDIEVSIVVEYPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSQ3</accession>
    <name>U4LSQ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to General negative regulator of transcription subunit 2 acc. no. P87240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSQ3"/>
    <dbReference type="STRING" id="1076935.U4LSQ3"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEEYQRK"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="298"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="440" mass="48248" checksum="F6F4C13CF0E2D3EF" modified="2013-12-11" version="1">MNRQGGWIGAPPPGVPSIPNRANSGLTFSQSVGGLTQPSTPLDMNEFPALGGQSQQPSQAWNRLNTASPSQPRGIPPPPTSQQQQTASQQAQQAAQQLQAQYDNSQLAMEEFRAQRGEPSEDFPALPRTQPGSLAGIDERALAEAARMGQRLPPHLEGMMQQQQAQQQAQQQMQQPEGEKKRAAAMNGAPGLTNNPPSNLAMGQQQPPRPSPAPGLSLPSQLQQQQPLQKPPGVNGDGPGVPMGPSTTTTSEDERFGLAGLFSAMRNDFGDGTSLAKGQDLMMLGLDINQPDGALWPTFASPFMELETGTVEPDFALPQCYTVLNTQPIHNKVHGFSDETLFYIFYTMPRDIMQEVVVSELAGRNWRYHMIHRLWMTKDPNGEVMQVSETAEKGMYVFFDPQSWERIRKEIILEYSHLDPRTTAGYPTAEQLVRQIGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT39</accession>
    <name>U4LT39_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Peptidyl-prolyl isomerase cwc27 acc. no. P0C1J2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT39"/>
    <dbReference type="STRING" id="1076935.U4LT39"/>
    <dbReference type="eggNOG" id="KOG0885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKNFLQH"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="539" mass="59443" checksum="66D9A524CBD94AB3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU03</accession>
    <name>U4LU03_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_14305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU03"/>
    <dbReference type="STRING" id="1076935.U4LU03"/>
    <dbReference type="eggNOG" id="KOG3265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CSYDERE"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="266" mass="29265" checksum="418649300305225B" modified="2013-12-11" version="1">MSVVSLLGVNVVNNPAKFLDKYQLEITFELLEPLSKDLEWKLTYVGSATSSDYDQELDSLFVGPIPVGINKFVFEADPPNVAKLLPSEVLGVTVVLLTCAYDGREFVRVGYYVSHEYDSPELAESPPSKPIYERIVRNMLTEKPRVTRFAIKWDSEESAPALYPPEQPGVDDLEDDADQYGADEAEREEALEDEEEVEAQGEDVEMGGADSSHPILIDEGSESEDLEAESSGESDEEGDDEADEMDAEMGDAEMGDAPSAPKPMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUI0</accession>
    <name>U4LUI0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUI0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6642" checksum="278FEDDB789BD7B0" modified="2013-12-11" version="1">MGALRDSIITTLIVKFFLKYATPYPTHLIIGILLVYAAYFQFHLKPLMIAIGDGQTTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUR4</accession>
    <name>U4LUR4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Probable peptide transporter ptr2 acc. no. Q9P380</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUR4"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPTIMFA"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX31876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="608" mass="68454" checksum="4D66BBA3CE06FDB0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUZ9</accession>
    <name>U4LUZ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein SGM1 acc. no. P47166</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUZ9"/>
    <dbReference type="STRING" id="1076935.U4LUZ9"/>
    <dbReference type="eggNOG" id="KOG4673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EEMHGYI"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="487"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="500"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="597" mass="67454" checksum="6CBBD4FB27E74B83" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVG0</accession>
    <name>U4LVG0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVG0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="12622" checksum="18785F62C29BA4D4" modified="2013-12-11" version="1">MKMEKRNQHFSFALRLTVYALGEELMFQHHFISRQLHFKFGLGIQSTYTYESDKNTSIHTRRIMPSQTLPMHGDTDVLKMWMSYDTIQAVSLTYFRVPKHAHLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW18</accession>
    <name>U4LW18_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Vacuolar amino acid transporter 2 acc. no. P39981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_14097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW18"/>
    <dbReference type="STRING" id="1076935.U4LW18"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="174"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="573" mass="61461" checksum="D00F9D1F5436099F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV20</accession>
    <name>U4KV20_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935225">
        <property type="protein sequence ID" value="CCX04997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV20"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="24" mass="2690" checksum="5EE2BC0EDFD26333" modified="2013-12-11" version="1">MLKYNISSGTFVGIIYRGECNNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVB3</accession>
    <name>U4KVB3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_04774</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVB3"/>
    <dbReference type="STRING" id="1076935.U4KVB3"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX05187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="556" mass="60524" checksum="044042E174E03FCC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVC0</accession>
    <name>U4KVC0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="15">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_03828</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="15"/>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVC0"/>
    <dbReference type="STRING" id="1076935.U4KVC0"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMADQFV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 22" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650881" description="Pheromone-processing carboxypeptidase KEX1" evidence="21">
        <location>
            <begin position="25"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="549"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX04846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="597" mass="66500" checksum="C4A2106DC0915289" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVE1</accession>
    <name>U4KVE1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to DNA repair protein RAD50 acc. no. P12753</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_05085</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935256">
        <property type="protein sequence ID" value="CCX05498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVE1"/>
    <dbReference type="STRING" id="1076935.U4KVE1"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="15">
        <location>
            <begin position="6"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="489"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="744"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="885"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX05498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1216" mass="139577" checksum="12FC6F29360E8516" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW41</accession>
    <name>U4KW41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935243">
        <property type="protein sequence ID" value="CCX05271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW41"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="11094" checksum="526D3A18A8114121" modified="2013-12-11" version="1">MSDFALGDPKAIVESYIHANRNPVTVALTTFLGALDDFNLRALVYGIFNALSALSLGAFITTMLAWIMQHPFHTAFIVLGLTLNIKPLAAAGCGALGPEAGTFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWS5</accession>
    <name>U4KWS5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWS5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="4025" checksum="C2F7C3D5A232E612" modified="2013-12-11" version="1">MGEGYIVLTIVTDTQTLVDHEVENVKRDNFLSHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXW2</accession>
    <name>U4KXW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to tetratricopeptide repeat domain protein [Neosartorya fischeri NRRL 181] acc. no. XP_001262752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935310">
        <property type="protein sequence ID" value="CCX06761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXW2"/>
    <dbReference type="STRING" id="1076935.U4KXW2"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11724" checksum="4CB0FFB721F521C8" modified="2013-12-11" version="1">MSQMEQYILFDPSASSGRRVLLLQGISGSGKTQIAYNFCVRNFERFWGIFWVNATNESTAKLSFQKMAHILGTTPTIDNVKEYLSAKEDWLLVIDDEKLGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYB6</accession>
    <name>U4KYB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Putative cation exchanger C3A12.06c acc. no. P87122</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYB6"/>
    <dbReference type="STRING" id="1076935.U4KYB6"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARAHFHI"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651509" evidence="9">
        <location>
            <begin position="26"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="817"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="744"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX06966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="911" mass="99366" checksum="DC298EC745B07E17" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYL9</accession>
    <name>U4KYL9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYL9"/>
    <dbReference type="OMA" id="MTIYISR"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17475" checksum="79D3E9292485AFA7" modified="2013-12-11" version="1">MAALDPTPTDITTLNIISSHKISAKTTRCLSILTSEGEGRKIVALRAKSSVASKAITIAEITRRELQKNGNDWYQYIQLESIVEERREKPGKQRKAEGDAEEKVEDVEDEEEEDPFQPVEDKKVRATPVMTIYISREALPTYAKKFGEMSSKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYS7</accession>
    <name>U4KYS7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYS7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="11173" checksum="FCBA7DAB4A90CD43" modified="2013-12-11" version="1">MISWRSLIFSRTRLWRTLICSPISALPSFSSCGFGYHYSSARRLHQRARVKIAVWINEAFPFVGKRITAEERKHQRLEMIEGFLLAFWVSVFWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYY3</accession>
    <name>U4KYY3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Regulatory protein cys-3 acc. no. P22697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYY3"/>
    <dbReference type="STRING" id="1076935.U4KYY3"/>
    <dbReference type="eggNOG" id="ENOG502S7ZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="32203" checksum="29F3175CA1C6C693" modified="2013-12-11" version="1">MANVPLSGLNHHPDSDSPQDLTSDSLEPFTDSLFFDLDLDRFLNSESYGDALGFRSSNGANGSCELLPAINEDSSFDKGGEVIGIHEDGVDTSLIDALQQEDFASTDALPLSTPGYGFLDIGFKDPIDDGVVGAIPTEIIEPLTSSNPENINGFQSTAAELIGPYELERSSTPPPPSSAIMMPCDPASPVSPGPSLSDLSSPTYSQHHTHHHIHITEADAHLMAIQESARMAAEEDKRRRNTAASARFRMKKKQRDAAIEKAAKDMADKVSNLEKKVTMLETENRWLRGLLIEKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ24</accession>
    <name>U4KZ24_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to U4/U6.U5 tri-snRNP-associated protein 3-like protein C162.01c acc. no. O74418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935324">
        <property type="protein sequence ID" value="CCX06945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ24"/>
    <dbReference type="STRING" id="1076935.U4KZ24"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDSSTMW"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX06945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="267" mass="30052" checksum="B667AFB08DBDD292" modified="2013-12-11" version="1">MDRNSGRREREPLPPPRRDRGDYRGRNTDFQHSKRRDSRSRSPEASGNSNNNGGYRGRDRGPYPTRGRGNDRGGRGGQRGGPGGRDGPGGRDGRDGRDGRDGRDGGKRSRSREHRDRGDRGDRGHDRDRDGRGDRGDRGDRSDRGGSRGGDRAPNRDRNERNRDNDRDHVGDRDQRRRSPSPRRKREATPEKEKLDEPEETDTMAIDGDEDDVEAQMAAMMGFQGFGTTKQKKVRGNDVGAIAKNKVTEYRQYMNRPGGFNRALSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZD8</accession>
    <name>U4KZD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZD8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9090" checksum="B3264611EED6040D" modified="2013-12-11" version="1">MLPSELAVSPSQLCGNPVLSGFHPTRNFLGTATNHVQPLPCEQIRNSAARINFCFFCTHTVLHRPGPEVHLGSQILLVYEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZH5</accession>
    <name>U4KZH5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein transport protein sec73 acc. no. O13817</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KZH5"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FVRHNAL"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="407"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="712"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1377" mass="150851" checksum="575E69CEE5D019F4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZP9</accession>
    <name>U4KZP9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX07980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZP9"/>
    <dbReference type="STRING" id="1076935.U4KZP9"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650895" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX07980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="492" mass="53731" checksum="EE6C58B3CBCC3AF5" modified="2013-12-11" version="1">MKLLTPLLLLLSLTAAIDLNIDDKASIKAAAARMAAKLRELYPRGQPWFNPGEFGILPSTTGKNIGYYWWEGGAAMGAWIDYWFITKDDQYNAIVTEALLHQVGPDNDYQPPNQTLSLGNDDQAFWGIAVLAAAEKGYPDPPPDKPQWLALAQAVFNRQVVRWDTEFCGGGLRWQVFRSNQGYNYKNSISNGLLFQIGARLARYTGNQTYADLAKRTYDWQKTIGLTNTTNYYVYDGAHVPDCVVTSKVQWSYNAGTLLAGAAAMYDYYSADLLNPPLTAQATLGNQPSMDFWQNETMNLLRGIDMPFFNMNDGLPNIMRESGCESSPRDNFARPPTCNIDQRSFKAYLSRFMGYTHQLCPFTRDYIMARLRPSAIAAAKACTGQPGGDTCGLSWLMGKYDGAPYGVVVGGVGEHMATMELFQTLLIGDAAPLKTMKTGTSKGDPAAGTGSGTVGDLRQTGPTTVGDRAGAGILTVVTAVGIVALSAWLVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZQ0</accession>
    <name>U4KZQ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Stabilin-2 acc. no. Q8WWQ8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935343">
        <property type="protein sequence ID" value="CCX07220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZQ0"/>
    <dbReference type="STRING" id="1076935.U4KZQ0"/>
    <dbReference type="eggNOG" id="ENOG502QX3S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651192" evidence="2">
        <location>
            <begin position="21"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="268"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="413"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="786" mass="88772" checksum="96499A9B9FD98532" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZT5</accession>
    <name>U4KZT5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935364">
        <property type="protein sequence ID" value="CCX07719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZT5"/>
    <dbReference type="STRING" id="1076935.U4KZT5"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANSHWFK"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX07719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="352" mass="40630" checksum="6AF16613E7911B95" modified="2013-12-11" version="1">MCMGGGGDDVEAKRHHEIEKLIRQDEKRMTKEVKLLLLGAGESGKSTILKQMKLIHASGFSKSDREDYKVIIFANLLDSIKITLEAMEQFDITLDNPQNELAVDLIVLDRELSRGEPFPKEYEQPFRRLWSDKGVQQAINRGNEFALHDNLIYFFDNLDRLFSQGYLPSDQDILRSRLKTTGITETIFDLGTLTYRMFDVGGQRSERKKWIHCFEGVTALLFLVAISGYDQCLVEDKDANQMQEALMLFESICNSQWFVKTSIILFLNKIDLFKQKIQTSPVNKYFPDYTGDPTDFKQASGFFQENFKRLNRSPQKDIYVHFTNATDTNLLKKTMASVQDMILQQNLKNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0G4</accession>
    <name>U4L0G4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935397">
        <property type="protein sequence ID" value="CCX08217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0G4"/>
    <dbReference type="OMA" id="KCRAISH"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="26023" checksum="F7BA0ABFF3E63458" modified="2013-12-11" version="1">MELPSFILLEVFSHLPGRDLVVASHVCSLWNNLITGRRRLRANTFVPSEYNPNFDTEYTELHPVISQLHFDNSVRSKEATYGVRKCRAISHDGVYQQLATCPAVKELRLAVLKWQPDVVIRNENGVRVKDVVEELARYKDTPVMNSFEDFFGKDRCSRMGFEKRKQMRRADMVSSEKVLVTFSNKVEKIKDGVLFKAENFRSQQPSKKSQKPEGYKFWGAFLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0K1</accession>
    <name>U4L0K1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0K1"/>
    <dbReference type="OrthoDB" id="10494837at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="132" mass="15692" checksum="F0D7604F5FD85BF1" modified="2013-12-11" version="1">MEPRDISFAETGLVRRTKSQKLLSLVRRGRKSDVSKDRKESVRARLSRSMSTSVRAIPRLLVGDKAKEPLPEEDKALKKLKRRESDERWRQFNVEIEKQKKIWEAENKDKVHTRQEPKAPKKRRESEQEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0L6</accession>
    <name>U4L0L6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to lipoxygenase [Metarhizium anisopliae ARSEF 23] acc. no. EFY98169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935432">
        <property type="protein sequence ID" value="CCX08810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0L6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19164" checksum="A06506E3C0DA4EB7" modified="2013-12-11" version="1">MATNTPEIKRLPQDVADYKLSSFDQGSPCLSFSSLGSPLTPLRWHSSKPPPWLTDGRQNKAKDSKGAVQHNPYDQGVVEGTVYGTQLALAQMYATYHDLMGIESIIPRQDALVTKQQLYQWSTAGDFPHCNSVPKPQQLAANQIFDSLGRKTIGRMLPNIMPKPFLDGYNKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0X9</accession>
    <name>U4L0X9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_07497</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935381">
        <property type="protein sequence ID" value="CCX07908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0X9"/>
    <dbReference type="STRING" id="1076935.U4L0X9"/>
    <dbReference type="eggNOG" id="KOG2070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWPGPDS"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
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            <begin position="8"/>
            <end position="67"/>
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            <end position="838"/>
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        <location>
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            <end position="1110"/>
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        <location>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="619"/>
            <end position="685"/>
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            <end position="93"/>
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        <location>
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            <end position="459"/>
        </location>
    </feature>
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        <location>
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            <end position="667"/>
        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07908.1"/>
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    </evidence>
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        <source>
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    <sequence length="1127" mass="125401" checksum="136A0971257964E6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
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            <end position="122"/>
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            <end position="104"/>
        </location>
    </feature>
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            <end position="223"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX08327.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="591" mass="66510" checksum="6E7AE74955E30EA6" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <source>
            <dbReference type="EMBL" id="CCX05999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1V8</accession>
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            <fullName evidence="5">Similar to Uncharacterized oxidoreductase yusZ acc. no. P37959</fullName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX09636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28683" checksum="C230E3C961CAA8D9" modified="2013-12-11" version="1">MTTTIPASSSPPPPAHLPKNPLLVNHITSAGGHWLPLDVTSPSAPSVVHTALSIYGHIDYFVNNAGYSLLGAIESFSEAEYRQQMEVNFFAPLRLIQTILPSMRERKSGCIVNFSSTAGLDGIAAYGMYSASKFALEGMSESLAKEVAEFGIRVVIVEPGAFRSRFLDNVVATEKGVGEDYKDTIVGEQIKTSGEWNGKQPGDVEKGVQRIFDVVTGTGLGKGKEGYLRCPLGRDLAEIVQGKIVDLVKTKTVFEDIWNSTDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1X3</accession>
    <name>U4L1X3_PYROM</name>
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        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935426">
        <property type="protein sequence ID" value="CCX08626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1X3"/>
    <dbReference type="STRING" id="1076935.U4L1X3"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="438"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="153"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX08626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="705" mass="77391" checksum="68118C679184458A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L311</accession>
    <name>U4L311_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L311"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="28" mass="3255" checksum="ED9C9CA7E05F7F64" modified="2013-12-11" version="1">MMMLNDDVLLDSLIFVHGFVDEEMVDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L387</accession>
    <name>U4L387_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CaiB/baiF CoA-transferase family protein C7orf10 homolog acc. no. Q7TNE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L387"/>
    <dbReference type="STRING" id="1076935.U4L387"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEFFHIH"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="559" mass="62492" checksum="3705C81FB5B18398" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4L7</accession>
    <name>U4L4L7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935346">
        <property type="protein sequence ID" value="CCX07248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4L7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4641" checksum="5B3FB4E93DF6FB25" modified="2013-12-11" version="1">MVVITSCHSEYPCGMVLKIYYAQITMLNVCVNPHYWMPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4N0</accession>
    <name>U4L4N0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="12">4.1.2.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_10294</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="12"/>
    <dbReference type="EMBL" id="HF935555">
        <property type="protein sequence ID" value="CCX10700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4N0"/>
    <dbReference type="STRING" id="1076935.U4L4N0"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PGPYGCL"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000054">
        <property type="entry name" value="Putative 2-hydroxyphytanoyl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="18">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="16">
        <location>
            <begin position="201"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="17">
        <location>
            <begin position="402"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX10700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="587" mass="62305" checksum="3177750AA8132F5A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4V6</accession>
    <name>U4L4V6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Inositol phoshorylceramide synthase regulatory subunit kei1 acc. no. O13994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4V6"/>
    <dbReference type="STRING" id="1076935.U4L4V6"/>
    <dbReference type="eggNOG" id="ENOG502RTPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQPVGFN"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="274" mass="29839" checksum="8B29EF097A562221" modified="2013-12-11" version="1">MLSQLRLPTPGKFLGYFDLHYGADIVLMSLLVNKCSGVFGVLAMLGGVKFSAIQFSMYFYSLLLFALLCHIAPSIRSRNPLSAISFAYITLLDALINILYTLLFGFSWFLVLAQKYHDASNPAVKSAAGTIDQHAGFTSPAYNVSHIAVSPSGQEAVAIPASAVVPESFSSGVLQPESATSILLIAAFWVVRLYFIIVAFAWARQVVRASATSIEGPFEGRNGGQGWQGKLGRALVGVGKGYWMGEGWIFHGGNKFRRDSGDRRRWGRRGSMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L548</accession>
    <name>U4L548_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04757</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L548"/>
    <dbReference type="STRING" id="1076935.U4L548"/>
    <dbReference type="eggNOG" id="KOG1771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEWPDYL"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX05170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="580" mass="64668" checksum="33810337D6C4F506" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L579</accession>
    <name>U4L579_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="41699" checksum="D48A3FF25A68B51B" modified="2013-12-11" version="1">MPSSDRRNIVGINAETVSNVTSTDFPGHWPGEDNSWNLEKFRNTFKVDFFKNDKHHAEFDLIHIDASIANAFRRIMMAEVHSFAIEQCYILNNTSVIQDEVLAHRLGFIPIVGNHETMRNMKWSRKGVDPKTNAEYPPTVNDTLILHLEVTCQRIPGAPKNETDPDKLYTGHTVYARDLQWRPANSTQQVKFGDDPVRAGNPDIVIAKLRPGQEIVVTSHAIKGLGKDHAKFSPVATAGYRLLPTIDIKEPITGKSAERFQKCFPPGVVEIVNGEAKVVAPRNDTVSREVLRHEEFKGKVQLGRVRDHFIYFVESAGQWDSDEIFLESINILQAKVNRLKKHTLRMLQQEEEQAEREAGIEDADAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7W7</accession>
    <name>U4L7W7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_13834</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7W7"/>
    <dbReference type="STRING" id="1076935.U4L7W7"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLWNNMM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109027" checksum="2576F8A6A6F7ED2E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L851</accession>
    <name>U4L851_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L851"/>
    <dbReference type="OrthoDB" id="10465640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651133" evidence="2">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="7351" checksum="5B2AA474FD10ECAF" modified="2013-12-11" version="1">MKFSASLLVSFGFIATALANPTLDTRDPKKGKHGGGSDDNSNAFASSSSSFAMPTGAPKMGAVLGAAVAAVAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8B3</accession>
    <name>U4L8B3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935954">
        <property type="protein sequence ID" value="CCX14361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8B3"/>
    <dbReference type="STRING" id="1076935.U4L8B3"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYVFNVF"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX14361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="21774" checksum="C88F1841577CF3A9" modified="2013-12-11" version="1">MGKTQSKLTQEQLTELQQATLFERKELQQWYKGFLKDCPSGSLNKAEFQKIYKQFFPFGDPTTFADYVFNVFDADRSGSIDFKEFIVALSVTSRGTLEDKLNWAFQLYDIDGDGEISYDEMLQIVEAIYKMVGSMVKLPEDEDTPQKRVAKIFRMMDKDENGSLTLDEFREGSQKDATIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8C9</accession>
    <name>U4L8C9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8C9"/>
    <dbReference type="OMA" id="KSYPTHP"/>
    <dbReference type="OrthoDB" id="10657587at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651733" evidence="2">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="467" mass="47698" checksum="90BBBFBDC9D699A2" modified="2013-12-11" version="1">MKTSFSVLLALALGAAAEYDRGKGGQWNGQEVHSDWEHHDHQGWEMQHQGWEQQKPEWKPQWQEAQAPAWGQPAAPQSGPSMEVAVASSPQAAPAPPPAPAPAPPAPPAPVAAAEAPSSVAPVEAPSSTWTPPATPSVAPPVETPSAPPAAPTVTPPVETPSAPLTTPAPTPTSTYTTTYETCITYPTIHSSAQSTFTTWTTRWETHTRTVIGTSTVWVDPTPVPGAPAWSEAPAAPAAPVASAPAWSEAPAAPSAPAVPSAPVVSEAPAAPAVSAAPDAPVVSEAPAVPDVSAAPVAAAPVSFETHQTVLTSYIPFMTTFAGADGQLYTTELTSTHWITKNIVSTISPVETAVQTQSAEPVSSAAPSATAEPTAEATSEPSSVESSTPENPKETSAPESMTEKPTSTKTSTSKTKTTTSSTTTEPPEEPSPTKTQPPEPSFANSAMSKGVSVGLVVGVAAAVVAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8J0</accession>
    <name>U4L8J0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8J0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9411" checksum="1A9C191D535E6F5D" modified="2013-12-11" version="1">MPNEKIWRCPKCNFWQTDPVCWKCGSVPPPSKRSCPSGSLNDEHNLRHDLHDENGYHGHYHDHDHDHDHDDSSLMTRDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8J2</accession>
    <name>U4L8J2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Rik1-associated factor 1 acc. no. O74910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8J2"/>
    <dbReference type="STRING" id="1076935.U4L8J2"/>
    <dbReference type="eggNOG" id="ENOG502RZG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="826"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1205" mass="133484" checksum="A81F79913D279C5D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8T2</accession>
    <name>U4L8T2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Folliculin acc. no. Q76JQ2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8T2"/>
    <dbReference type="STRING" id="1076935.U4L8T2"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="191"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="767" mass="78884" checksum="1891CDEA1923AA29" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8W4</accession>
    <name>U4L8W4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PCON_06146</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CBS 100304</strain>
            <tissue evidence="27">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="HF935296">
        <property type="protein sequence ID" value="CCX06559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8W4"/>
    <dbReference type="STRING" id="1076935.U4L8W4"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="26">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="371"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
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            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="16519" checksum="E9B65678D8C6FBED" modified="2013-12-11" version="1">MMLRGEEGAAAVMGAALRTGRRLAQGVGLTDEAPKFVRVFRAAATVLAVLRVVLAGIILIIAAIESAKQRDELQEAITSLFCRRFQAKQLQDNIMATESHHSQVEAYLATYNILVKQPNMPPEATKQVLENLVAPIVDGVKSDMAAFTDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAY1</accession>
    <name>U4LAY1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935591">
        <property type="protein sequence ID" value="CCX11097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAY1"/>
    <dbReference type="OrthoDB" id="5414341at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="148" mass="16818" checksum="14947461B1A62261" modified="2013-12-11" version="1">MDENRNKPRLRKKSNIKTDCKWAVILAKHCYPSGPMKGQRMPAWTFKARCLEHNHPLQADPFEYIQHMHIHPLNKMPKKLEASTSNTGIVDAEDLSLNVARPTETSTASTEIGDAEYNISAEGERRLLPSLSTTRLWTTEHPCTVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBJ5</accession>
    <name>U4LBJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBJ5"/>
    <dbReference type="STRING" id="1076935.U4LBJ5"/>
    <dbReference type="OMA" id="AFNGNDI"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX17449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="664" mass="69293" checksum="C8D4D28317FA3189" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCI8</accession>
    <name>U4LCI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to rRNA-processing protein EBP2 acc. no. P36049</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936487">
        <property type="protein sequence ID" value="CCX16621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCI8"/>
    <dbReference type="STRING" id="1076935.U4LCI8"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="397" mass="45424" checksum="63D4B7D13A53967B" modified="2013-12-11" version="1">MGKSKLKTALARHQGRDIIKEKRLKVARRVERERSAKANGEEWVDEDSDNAPELIDTSVEGAIPKKAEKFTRTLPSKKAPVGEDEEDKENEEDEEDEEEDEEEDEDEEEEEEEEEEDVALSDIESDNDLATEDVIPYQKLTIDNHAALTTLRNRIAVPIAKLQFSEHQSLTTTEPVEIKDIDDDLNRELAFYKQALEAAKLGRVLLKQEKIPFERPVDYFAEMMKDDEHMGKIKDKLLEEAERKKRSQEARKLRDLKKFGKQVQVAKLQEREKEKKQSMEKIQLLKRKRAGADAEGEKEDDMFDVALDEQTKDEKRGRKKGDRTSDDKSRAKRQKRDTKYGFGGKKKHSKSNDAKSSGDLGDFSAKRNKASFGAPGPKGKKRAAPRLGKSKRAGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCM9</accession>
    <name>U4LCM9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCM9"/>
    <dbReference type="STRING" id="1076935.U4LCM9"/>
    <dbReference type="eggNOG" id="ENOG502QSSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NHWNAWK"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="427" mass="49808" checksum="A653DBE9AD77A8DE" modified="2013-12-11" version="1">MTSLINFRKLFDVVTGVLTGDDRFTGLPRVIAVDYETSHDRRARTLKHLLRANHHQYAVLYNRLHFHNHLPHILGSVFLLGGDEYKLQTIYDEDHKELEPWQDAPQEVTVEDWRDFLGNKGYQRAYLDFFEDELVRLDYDWKEVVREYLLAGPEPLINGLISGLGHSMIHLGYAFELNSKDLAMEALVLNATNYDFLHQYIDTPAPAVQASIIYTPLEILEQIKADKRFDNLFSLPGERNLKRLFALQEEAVLEYFHKLQITDITHLHKQFTKLATTLLMTTHAPGDPQYDFFFCHTLTTAYAIRILLPELPRSCSESLIRQHWLFIVFVYIVQFRPVISPQLVEGVDTQGKSWDDIVNQALSRKLPDTHFVKAIRTIKMNAELWPEEDEWYKKAACKMVKEFRRWVGFGALGEEEEVRRNGLEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCY5</accession>
    <name>U4LCY5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX29964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCY5"/>
    <dbReference type="STRING" id="1076935.U4LCY5"/>
    <dbReference type="eggNOG" id="ENOG502S5VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASMHAYR"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="182"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="441" mass="47124" checksum="70AB62A5BD207EEE" modified="2013-12-11" version="1">MTIPSGTPTGGHSSSYDTYDPESGLTESTLRPVLLRSHSRRSAASVNSHHSSFPFPSPTSLFPPTPFHPTPFPPTPFPPPPPPPPSLRYDSHTRDSTPVSGDGSNNGLPRSHSTHSHTSHTSAASHESAPSAPSAVVVPGASATAASAKSSSSETTIKPQPSITSHAYSLATSDFDRPLFDYRILAASMHAYRHLSIFRRFGRLSMANLLSYQDELTELEASLRVLNNPDTGARAGAAESDPAETRRQLMRKLRGLLKDYYETLLLQEQIFTLDPPRDSDVAVLGDLAPAYPSGGGVVEVDQHIDDLVSLGLGERDSLEKLVGRYIPSLFPGRVASVEDLRQRNRSARDVAGLFNPFTRRVTRLVIALGTAAMMLAPMVVLSVVKEERWKLGVVAGCTMLLAVAVALGTRGRGGEIVMVISAYAAVLVVFVQGDCGGRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDB0</accession>
    <name>U4LDB0_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDB0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="172" mass="18155" checksum="4D3B3E382B1C6042" modified="2013-12-11" version="1">MVLSAASIALAIRPFQRATVATGEHPPSTLKRRTINSALPLAHQTDNFDLLPAAVSAVLATCARVTEAVDSILPDASSRYPDASALVAALRDQIITTSGRTFHAGDLVDGIKNIALSTWLLSPADLTPQSVADSVLTWVRDLALIPEETTWKKSGILQASGPYDEPFLGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE94</accession>
    <name>U4LE94_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE94"/>
    <dbReference type="OrthoDB" id="10464780at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15632" checksum="D52C56922A4BACCE" modified="2013-12-11" version="1">MKPPLLLRWWKEKLSLHHDCWAACAVVPLPHTLPSSIHPRVPPSSTRLSPSLHLPPSTPHHTSSRRRQTPILFIRSDLWKIQTINVTNNLLAGLTRTGVALLARTTKRNELVESAGPVVERKKKSEKRKIAVKQVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LED8</accession>
    <name>U4LED8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LED8"/>
    <dbReference type="STRING" id="1076935.U4LED8"/>
    <dbReference type="eggNOG" id="KOG1484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="549"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX29897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="845" mass="89951" checksum="52844115947625FF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LET7</accession>
    <name>U4LET7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Cell wall integrity and stress response component 3 acc. no. Q12215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_09387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LET7"/>
    <dbReference type="STRING" id="1076935.U4LET7"/>
    <dbReference type="eggNOG" id="ENOG502S7MH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTSIGCF"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651391" evidence="9">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="249" mass="26257" checksum="F7C203F5859BC1B3" modified="2013-12-11" version="1">MKAFHSALLVALAGLATAIEDASYYGCYSSAGMMTESIAKDTFMAVGACRPACTNGTGFAVMAMTKGTSCWCGNTFPAKSYRVDDTKCKQPCGGYDKEMCGSRLGEYFSVYKTGLEKDPDTDPEGSSSASKTSTSSGTSSTSLTSTTTSSASDGGSGAVNKAGVAAGAVIGVLAIITIAVGFWVFLRKRRRQKVEEEYRKSAAVRGFVQKPASDHRLDPGMVQRRDSVGSIADNQDYSRRILKVTNPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF39</accession>
    <name>U4LF39_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF39"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11518" checksum="BF3682E4A4436F4E" modified="2013-12-11" version="1">MSQLLRESSPGPGERGYAPVLLDVIIGAVRYKVRSKSDLVEALEKRESQPETPTVIVCSSEELPQDILWYIYGSFAPQLLNFGVYLPGCIKATLFDRISSRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG57</accession>
    <name>U4LG57_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG57"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="280" mass="31824" checksum="80C88477F1E22AA7" modified="2013-12-11" version="1">MVHPSVDEMLIEEPPPDYPPPQYSRCDTGLPPPPYNPRARVRHILELMARPPRPPSPGPERRDPRPPPPLYFTHSADFWRPPEPAEREQQWAEERAATDSDTRPESVTRPRLEPIHTQNPSLSLSERAERAERIRIWAEQTASAREQRQSSGSSLRPEAYRRRRPQPSSSPSLIDRYDRVILYHVATSEEDVEPPQPPRRNLTGLRTRGRLPRHRVSPFRNRICDTSNRPVDGVASSASGMDQGDLLDSAMWFVSGVLCGVALTVAVMSYHFGQGRGWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGR9</accession>
    <name>U4LGR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGR9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="17009" checksum="DCEECE1D2C9E0810" modified="2013-12-11" version="1">MGGTRCRERVLRSPLSVVDGRRGRWWKPGRKKVEKKLEMTADELAHLTGDECGREVFWLNSLTLPALGRWSLLTRMSRSTISGPARHLLPSYIDGLVLTPTKEDLIPSPVFLVMRLQFGPSESDIGICLLYAFNQQRPSSDSLRVRYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH95</accession>
    <name>U4LH95_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized membrane protein C1322.03 acc. no. O94543</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LH95"/>
    <dbReference type="eggNOG" id="ENOG502R2RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIWAGMM"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ21"/>
    <dbReference type="STRING" id="1076935.U4LJ21"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDLYQPC"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="333" mass="36724" checksum="F3CF9059EA020DFB" modified="2013-12-11" version="1">MPHLLSHEIGPIGFGLMGFTWRPTETPDSLAFATMRTALACGSNLWNTGEFYGNAPTMTQNLSLLRRYFTQYPEDASKVILSVKGGMDIPTFTPRGDREGVRNSVENCLRLLDGKKKIDIFECARVDKSVPIEVTMEALKELVEEGKIGGIGLSEVGAETIRRAAKVVKIAAVEVEVSLWSTHIFTPGGVAETCAELGIPIVAYSPLGMGFLTGQWREANEVPEGDRRRGYDRFQGENWGENMRIVEKLRLVAERKQCSLAQVCIAWVRQRGNGEGKPVIIPLPGATTEERVRENNTVVKLTEEEMRELDGIVEKAEVKGGRYNARGAANLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJB3</accession>
    <name>U4LJB3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJB3"/>
    <dbReference type="OrthoDB" id="10444250at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="211" mass="24030" checksum="E7313901B609BE28" modified="2013-12-11" version="1">MTQPPPHQTSNRSFSRNPSRPRNEGSSNSTPVTHHISPQLSTALGISQPDAKFEAMQQELLALTVRRREIWQRIAFLEGIRPTSPDSSHHEHDADDSHPAENPGAATETLPDPYTPPVNTALVRMRDFLRHMRLEHPQFIQDLKDSQQRNKPLKGLSARKYKGFIEQLAFYCQEMVEERLDKFRAENSGADDEFIEALRGKFYETLLAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK41</accession>
    <name>U4LK41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK41"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="120" mass="13147" checksum="626A846D0AAB4EDE" modified="2013-12-11" version="1">MELTPEKKQRLLNLQPTQVSCAPVAPMKGVSQPTNRAQIAPMIRIPEPIAPPFRAPIAPMMGHTPPVRADQSDTDMQGQKLIRRNNFDEKMCQLACCGCSNIGEDTDGQGLVKDGKGHWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKM6</accession>
    <name>U4LKM6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKM6"/>
    <dbReference type="STRING" id="1076935.U4LKM6"/>
    <dbReference type="eggNOG" id="ENOG502S0EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GINIMED"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651681" description="Extracellular serine-rich protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38348" checksum="FFCCB62450C2DA9C" modified="2013-12-11" version="1">MMLLRTTLFSAATIFSVATAQSASGTATSSAAVATHTIKVGWPIGQHAFYPEETTANRGDKIIFEMYPANHSVVRMDPSSPCVPYDYAGHPSNEFWWSGFYPTQDTKNPLTYDIAINTADPIWFYCSAPGSCKTYSMVGVINVNNTDHNLTEVKAAATKVNFSLSPGEKIPDESGNVPGSTSSAAPASDNKSNGLSGGAIAGIVIGSIAAFSLVGILFFLVGRKKKAQEVKEKNDRDAEIAAAAMAKHDQQPPVYSDPAIDPRYSMPPGSPPPHRDTFFGGKSGHQSMVAEHTGGSDGYEPRNPNRLSELPSQNYDPVEIYTPGLPEHSMGFPPIPNEPLPDQNGDDHDRRRDTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKT9</accession>
    <name>U4LKT9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935831">
        <property type="protein sequence ID" value="CCX13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKT9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="2766" checksum="B94125A95213FB70" modified="2013-12-11" version="1">MISRLRTQCAVVEPQANHKVSPSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLE4</accession>
    <name>U4LLE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLE4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7422" checksum="67C73C9887517C5A" modified="2013-12-11" version="1">MHGRVRVLPPGSPQLGLRSTGGKTYYVYSSPERIATHSNDYNYRLLYIHGRLLSNKPTLHVSMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM61</accession>
    <name>U4LM61_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_14264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM61"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="249" mass="28133" checksum="6C0B3A43E1A1CADF" modified="2013-12-11" version="1">MVTTRSRSYSRNPSPNITATKNKRRLSKSALEDDASGSKRRRVLMPDTNDNAGQEDEPGLLVLSDNVNIANNLGSYSDPWPSDHKETVDEDADDEPNTWDSRLWDKSGDHWSDDDVKDNQSDSDPWPSDHKETVDEDADDEPKTWDSTLWETSGDHWSDDDAQDNQSDSDSVIWNTEEAANEDADDIDPSEDTLLQSDDLWATDDERWANSLVRPLDSTRNAHDESDSDLSTLDSVFDEFNPHVDLFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNJ6</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_02438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936282">
        <property type="protein sequence ID" value="CCX15966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="344" mass="38859" checksum="1CDF46B43D7A6A52" modified="2013-12-11" version="1">MSLNSIIDYALLCPDFSSYLTLNCREIVSSALKQSYGYICPFDIRYTLPVSPIFQNGSPAYQLMTDHPDLNYLLIEQLNGELQEHKRLIQILTDANGSDMCKDEAELVYGPGVRGLLRYLVKYHILRRSTPSRELRMQKMTEFLKEYYTYTGIHEIAGVYECLSDIISQRLEKSPNDEEVEAECSYLIAQLEVLFIPEHGDTGKWLWQKESSKSEEELHILHREHKGFFWKPAQDALHQVVDEGNALSGRRKSIHYAGDLPYARPKRNNSDASDMSNASDETDLSVDSVEDGLRGLELMTGKPLPIPLMMDQNQIRPGLLQALTGTNLKGLGKFVGPAGPVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNW6</accession>
    <name>U4LNW6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10378712at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651768" evidence="1">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="12626" checksum="80808DFAFB5A3F9F" modified="2013-12-11" version="1">MKTTLFTSLSLVSLSFAAPSPGGPNHAIRQTDSRVIARAASRAIIGCEWPVGATKITGIISCCKKADLMDCFEQPFNVNCKKEGWVETCCKKENGAVVKDGRGGKCRKEDDGVRLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNY4</accession>
    <name>U4LNY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNY4"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="142" mass="14812" checksum="D9F0998F9604BF45" modified="2013-12-11" version="1">MTRVPKNTQAILAERGDCVVGGVGRVGRLGGGGGKSVAPLSDQGGWWCEGDLGSRLFGKITGSVRRVVPVQEEEGIRAECTQYETFAEAEGGKELPGTEDDWELRAVWKELKQKGSPTIPHGAQAGEKKYIGGAGGGCGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNY7</accession>
    <name>U4LNY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Plectasin acc. no. Q53I06</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the invertebrate defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNY7"/>
    <dbReference type="eggNOG" id="ENOG502SVYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187789at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00107">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0211">Defensin</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651530" evidence="4">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="5">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10023" checksum="8D9B667614F1C1BE" modified="2013-12-11" version="1">MQFTTAFTVVLTVFGLLNGVLAAPQPLPEGHAVSDPDANPDHYAGVDNALIKKRGFGCGGPWNEDDMQCHNHCKSIKGYKGGYCASAGFVCKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP29</accession>
    <name>U4LP29_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Zinc-type alcohol dehydrogenase-like protein C1198.01 acc. no. Q9P6I8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_14357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP29"/>
    <dbReference type="STRING" id="1076935.U4LP29"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYAGYCN"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="66"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="446" mass="48933" checksum="48F61C7BB4CFB8A4" modified="2013-12-11" version="1">MAMNAAANLIEKVVGRGDATVTTNVSNPEIDIAKYADTTTPMKALTWQGKNHVEISDTFKPKIVNPDDVIIKVTGSTLCGSDLHLYHGAIIEMQQGDILGHEFCGIVDSVGANVKNITPGKRYVASFQIACGNCKMCDQKLSSQCQNTNDSTVQNALFGSRTAGLFGYAHLTGGYAGGQAEYVRVPYGDVNLLELPEDVPDEMGLYLSDVLATAYNAVQDTRVYPKDTVAIWGAGPIGLMTALFALKNQASKVILIDNNWRLDWCKQRLPQIETLDYTALPRGKSVTAELHERVPGGVDVSIECVAGEYAKGWGQYFEMLLGMATDTSEIVNEMITSTRNYGRCGITGAYVGYCNHFNIGSLMERGIRLIGNGQAPVQKYWEELLQMIQKGELDPTIMISHRIKLEDLAKAYRIFSDRKEEDGMMKVFVETKFSAPHRAGPMLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP99</accession>
    <name>U4LP99_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP99"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14477" checksum="8D983AA5FA7C351A" modified="2013-12-11" version="1">MSYQNLMMPPQESNDDYSTGISDQYPAAEAAASIYIPGLLTVSVVACPLFHLSQTPLLHISPRLTRFFETHGIPNSIFYDKTDIELSANFEYRIAFRRRTQSTKHLLPSYIRKHESYLRDWYVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPE0</accession>
    <name>U4LPE0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to D-lactate dehydrogenase acc. no. P52643</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPE0"/>
    <dbReference type="STRING" id="1076935.U4LPE0"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIVTAHQ"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12183">
        <property type="entry name" value="LDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058205">
        <property type="entry name" value="D-LDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026:SF1">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="110"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="359" mass="39798" checksum="3C39E3953FB8EF48" modified="2013-12-11" version="1">MKVAVFGTKKYDKDSFEAANESSKIDFTYLDARLDAKTATLAADHEAACIFVNDQCDEEVLQAFKDASVKYIALRCAGFNNVDLKKAEDLGLKVVRVPAYSPESVAEFAVGMILTIVRKYHKSYLRVREGNFLLDGLTGFNLSSKTVGIVGTGKIGLLTGKILAKGFGCKVVAYDLYKNEEKAKEYGLEYVETLEELLRQSDVISLHCPLTEGENGTRHMINKERLEEMKKGVVLVNTSRGGLIDTNDLIWALKTGHLGAVGLDVYENESSYFFADSSSKIIYDDNFARLLSFYNVFVSGHQAFLTEEALLNIAQTTIQNLKDLEEKGECQNECKPEKKGDKGGKKEEKADEKGGQIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ11</accession>
    <name>U4LQ11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein RF_0381 acc. no. Q4UMH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ11"/>
    <dbReference type="STRING" id="1076935.U4LQ11"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="331" mass="36351" checksum="0001DE20D000A0A0" modified="2013-12-11" version="1">MPSLTTVPTEILLLVSDNLDIPSHFALASSSRSFYERLLPALYRRAIATEPGELINNALIRNRLAALDRFIEYGLNINTLLPYGLFTRRWYSWSDELPTAVLAAAIRGSIRLVRLLIERGADVNIGTMPANETPIHVAARCGNIDMIRELVAAGADIEARTQNKWTPLWVASHCKMWEEGKRKSDTIEAIKVLVELGADLEGRAENEDTPLMEAVLSGFVKGVQALCEAGADVNSMDGTGIAVLHRAAELGDRAIIKTLVAHGADVDKMVPNSAGIMWKPIQFFAAGRQRYMLWLEQRAIADVPDPESGWAEKGAAEISALLIPRETPMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ44</accession>
    <name>U4LQ44_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein FDD123 acc. no. O74631</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ44"/>
    <dbReference type="STRING" id="1076935.U4LQ44"/>
    <dbReference type="eggNOG" id="ENOG502QQVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFTTMFM"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="327" mass="36619" checksum="137FBC7A8F738E40" modified="2013-12-11" version="1">MPSIPIDIDPGTLIARANTALDHNRPIANNNITTHGSDLNWAICALHALLLIGVIVWTYMTNPRRRVFHYFAISILSVATVYYFIIASNLGGAAVPVEFRGGNILNRTRQVFYARWVGYLINFSIIWFALLLMSGVGWASILFTTGLTMLWSSMFLMGMFVRSSYKWGFFVFAIVLWALITWQTMGIARSYAGTIDATTHRTFSLLAAWTLFFMMLYPISWALSEGSNRITNDAEQIFYSVLDVCSQGVFSLVLLFLSRRLDFDILGLAFTEYGRIKNRISEKMHHANGTAARPAGGVVSGHQNAVEGYRNDVAQAHAEHARPRDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQJ9</accession>
    <name>U4LQJ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQJ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6108" checksum="E425EF4C482B389C" modified="2013-12-11" version="1">MVPFKETSGMIVIDMGSVILGCEGYVLLLSETTVQNKFKCVLCCEKLVRKCCFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQK8</accession>
    <name>U4LQK8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQK8"/>
    <dbReference type="OMA" id="QPHRRRM"/>
    <dbReference type="OrthoDB" id="5384020at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21335" checksum="81E270C10D4D1856" modified="2013-12-11" version="1">MSNNNDNNQPSHPRDRRASLMPGTSLSDFLSSSRQPTTTSAYPGPITTAAAHANQRRMSMSSASGSPPQITTSFRRGSVSSVSSMSSQQDESAIDDTEPASGTSPSSPFARRMSWGARALRDVRIPSARVPPSPGASGSPTVARGFWPESKSSYPTDSAFQQRRQSMPPPPATAMPAPKDKPTDHLQERILRNELYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRB6</accession>
    <name>U4LRB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRB6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6529" checksum="F12F71540729814A" modified="2013-12-11" version="1">MQALKRLDGRRNDRLKELDNHPALGKDYLKDIYTHKFVRSKHVPGTAESFISSVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRG0</accession>
    <name>U4LRG0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRG0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651600" evidence="2">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6250" checksum="B7837CCE5EB421EE" modified="2013-12-11" version="1">MQFPIITLMLSLALVTIAAPTPYIPIGSLNLPAVSARSPQSNTPPPPRPPKGVMPPPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRX0</accession>
    <name>U4LRX0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pc21g02610 [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002567325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRX0"/>
    <dbReference type="STRING" id="1076935.U4LRX0"/>
    <dbReference type="OMA" id="CESGRDY"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6728" checksum="956CE358FB2A5AF2" modified="2013-12-11" version="1">MTSSYYKGAGGITYTFVVEFACESGRDYYVKHDPVHLSFVKMVGNIVEKAQVIDFVPGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS92</accession>
    <name>U4LS92_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS92"/>
    <dbReference type="STRING" id="1076935.U4LS92"/>
    <dbReference type="eggNOG" id="KOG2516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WWVEVRM"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062423" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="535" mass="59031" checksum="7E06165708538174" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSA6</accession>
    <name>U4LSA6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative epoxide hydrolase acc. no. Q06816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="396" mass="44529" checksum="744BF7EAC69E46A4" modified="2013-12-11" version="1">MASFELPSFIKSTIPVAPFTASIPDSEIESFKTLVKLSKLPPAVYETQHRKYGVTAEWMRAAKTTFETTFDWRAVESKINSYPQFVATIDDFTVHFVGVFSPDPSAIPLVLLHGWPGSFYEFYPTIAELQKLSQPFHIIVPSQIGYCFSSKPPVDKDFGTHDATAVVQKLMKGLGLDGYIAAGGDIGSFIARALTNDEACRGCHLNMYIQPDQQQGVSESTPADEIAALERSKLFGSHGRGYMIMHGTRPSTISHVLASSPVALLAWLGEKFLAWTDTDPSMEDILEKVALYWFTETFPSSIYPYREIVDRYEDQEWQKPLAIKKPMGFSWFPFELASVPITWITEDTSASGNCIWWKKHEKGGHFPSFEMPAEYAQDIDMFVKKLKEVEAEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSG5</accession>
    <name>U4LSG5_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to Telomere length regulation protein elg1 acc. no. O43086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935431">
        <property type="protein sequence ID" value="CCX30241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LSG5"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HDDIEEW"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="788"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1328" mass="145805" checksum="F8B02A426DE8B30D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSH8</accession>
    <name>U4LSH8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Serine/threonine-protein phosphatase T acc. no. P53043</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSH8"/>
    <dbReference type="STRING" id="1076935.U4LSH8"/>
    <dbReference type="eggNOG" id="ENOG502S1W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MERIRYD"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="897" mass="103330" checksum="A9B51EF06E9200EE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSK5</accession>
    <name>U4LSK5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935809">
        <property type="protein sequence ID" value="CCX32305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSK5"/>
    <dbReference type="eggNOG" id="ENOG502S7FM">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </feature>
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            <end position="374"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="460" mass="49642" checksum="0AD882CB5D1302C5" modified="2013-12-11" version="1">MLAFNNENAILQAPSKTSGPNKMLAKTPFKMPLNDENGAGEMFPKTGGKKTFLAGPAAFMTPMGPRRQALAGKTTNAKAKNLGPFGGGDQGGKGTIKPQKSQLQNAEPMVEVIAEPAEQWPEIEYMPPVPADLPFVPEGFEEPNYTWLAKNYMRGCHRAYLAGVDDNGKTELQRKLEKNMLLLDAELEEETLAAIENAKGTSRSKPVVAVANKAPALVKRSTSRPAVATRRSTSRPASRNEPSKRSTSRPATQRSNSRPATTRPASAASNTRPTSAASTRPTSAASVRPTARARPPPSLSAGTARRIVSSEARKAAEALARPAAPRPESRQGRSVTRPESRQGRTTSTTKSTSVSKPVQKSRSVSRSANVRSTRPAAAANQVTKSTIGYHTGKEVGKEVKKSLETALEAIERVQREDEDREQGGEFLIAQEEEEDGVIVDMPSPVFLELEDEEEFVMTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LST7</accession>
    <name>U4LST7_PYROM</name>
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        <recommendedName>
            <fullName evidence="2">Transposase MuDR plant domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935851">
        <property type="protein sequence ID" value="CCX32445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004332">
        <property type="entry name" value="Transposase_MuDR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03108">
        <property type="entry name" value="DBD_Tnp_Mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase MuDR plant" evidence="2">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
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        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="666" mass="70295" checksum="966F69E80FB8B8D2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTF4</accession>
    <name>U4LTF4_PYROM</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
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        <property type="protein sequence ID" value="CCX30776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LTF4"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERAGYYE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="511" mass="58691" checksum="C5B12AF3944A7C67" modified="2013-12-11" version="1">MSDTILHPDVAAGAGNLELKENTTVVVLGASGDLAKKKTFPALFGLYRNNFLPKDCHIVGYARTKMDQKEYLSRIKSYIKTPVKEMEDQLDAFLKKCTYVSGQYDQDESFQRLRDHLNELEKGRPENHRIFYMALPPSVFTTVSQHLKKNCYPDRGIARLIVEKPFGRDLQSSRDLQKSLEPDWREEEIFRIDHYLGKEMVKNLLILRFGNEFFGATWNRNHIDNVQITFKEPFGTEGRGGYFDDFGIIRDVMQNHLLQVLTIIGMERPISFSAEDIRDEKVRVLRGIPAIEPKNVIIGQYGKSLDGSKPGYLDDDTVPKDSRCPTFCALAVYIKNERWDGVPFILKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVIRVQPNESVYIKMNSKLPGLSMQTAVTELDLTYRRRFSDLKIPEAYEALILDALKGDHSNFVRDDELDASWRIFTPLLHYLDENKEIIPMEYPYGSRGPAVLDDFTASYGYKFNDPAGYQWPVQSTLPTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUL8</accession>
    <name>U4LUL8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RNA-binding protein with serine-rich domain 1 acc. no. A6QR16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
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        <property type="protein sequence ID" value="CCX33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="LD23870P-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
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    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
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            <end position="82"/>
        </location>
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            <begin position="165"/>
            <end position="296"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="79"/>
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        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
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            <begin position="182"/>
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        </location>
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            <begin position="203"/>
            <end position="225"/>
        </location>
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        <location>
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            <end position="241"/>
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            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="39296" checksum="692355B0F1919AAB" modified="2013-12-11" version="1">MDRSRSRSFSRKRSRSGSASYHSPDARGRSGSPRSRSRSRTPDRARSRSGTPRSRSRSRSVSRGRSGSSRGRSVTRSASPAGFQSSKIVIEKLTKNVTEDHIREIFSTYGDIKTVDMPVNRQFNTNRGLCYLLYNNAASAHAAIAHMHEGQLDGAVINVSIVLPRRPPQGAPSGPSASGPTARGGGRFGGRGGNPRYRSPRRGAGGAGAAGGRGFGGDNYRGAAGGDSYRPRSRSRSRSRSRSYSSRSRSPSKSRSRSPYRRRPAGGSGRRGGGDYSPPPMTTGRNRGGRNGGGRTGGGDAVLVVLADLAVLLHVEAVEVEVEEHRVEAVVEVGAREVEPVVVAVVDVDGRSEREPDGNQMRARVGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUR2</accession>
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        <submittedName>
            <fullName evidence="2">Similar to Heat shock protein hsp9 acc. no. P50519</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_11541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP9/HSP12_fun"/>
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8632" checksum="2AC73A4306504230" modified="2013-12-11" version="1">MSDSLRKPFSDCVFEKMTPDSSKSTIDKAKENITTTADRAVGEMQPDSSKSSTQEGFDKSRHEKDTIVDKTKNAIGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV07</accession>
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        <submittedName>
            <fullName evidence="3">Similar to Spliceosome-associated protein 145 acc. no. Q9UUI3</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_12381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LV07"/>
    <dbReference type="eggNOG" id="KOG2330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="287"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="580" mass="66697" checksum="D8264CA2CE6ED918" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV69</accession>
    <name>U4LV69_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935799">
        <property type="protein sequence ID" value="CCX32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV69"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="4052" checksum="A144E764529733F9" modified="2013-12-11" version="1">MLLPPCSIFITNQELLSSNSMQKQTQKQTTVTAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV95</accession>
    <name>U4LV95_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_12968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LV95"/>
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    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="503"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="768"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX32336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="818" mass="90699" checksum="54F512CD52A4AC80" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWI4</accession>
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            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
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        <name evidence="11" type="ORF">PCON_01864</name>
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        <name type="synonym">Pyronema confluens</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
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                <person name="Gabaldon T."/>
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                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="12">CBS 100304</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LWI4"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
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        <location>
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            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5004652462" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
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            <end position="512"/>
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        <location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="57116" checksum="5B800FC37697412B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX28</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_03022</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
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                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936394">
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    <dbReference type="STRING" id="1076935.U4LX28"/>
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    </dbReference>
    <dbReference type="OMA" id="TSYWPSI"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="690" mass="70592" checksum="D7C348434E7A0EC3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU60</accession>
    <name>U4KU60_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU60"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="12205" checksum="2DE0EF3AC552C6F6" modified="2013-12-11" version="1">MAPINHSSCTEGTCIHHDALMNLLLEMIWPITHADQATDGDVEDKRADFEKCLELFEGKEWKDELMGYCIKCMLDFFGHPEMYEPVVQPYFTESGHVESCKYCTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUR0</accession>
    <name>U4KUR0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUR0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="236" mass="27393" checksum="C947FB995C2A32B2" modified="2013-12-11" version="1">MPTQSSLKKFGFDSKYWEDFEQFNNNSLHYSSHFSPRLNTSNTLLQPLYNHTSCPGPRSLTTNHHLSNLSEHDPLPPSPIPKPLPKFPRQFPEPIVLRIRRSSRHARLPQRTLLLQAANSARRAQQHCSPSIHIKCLHGLPIPKSLSRNPRIHYGRIPLQKTLQQHHQPIRKQLSKQQRLRIRQKAMEEVIRRLYRPQRPPGGQPTLQHPRPNPLHPQPPNPSSSRGSRSRSRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUT5</accession>
    <name>U4KUT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Short-chain dehydrogenase TIC 32, chloroplastic acc. no. Q6RVV4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUT5"/>
    <dbReference type="STRING" id="1076935.U4KUT5"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHPGNAI"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="357" mass="38489" checksum="C891CDB9847D402C" modified="2013-12-11" version="1">MSIFNSNNTSITMSLKLQASDIPKDLSGKVAIVTGAKSGLGYQTTYLLARAGCTVYLAGRGEAALKDTIIRLTTEYAELSSDHLHALECDLSSTATAVASARSFPSDRLDILIANAGIALQNDTETSPEGWEKHFQTNHLGHFAFITELLPKIESTAETYGSARVVVVASEAHKFISGIDFEAIRKPVVPGLQGLVGCMKRYAQSKLANIMFAQELDRRLKAKGQEKVFVAAIDPGQFILPLGAIATNLGGTGEQLGYPEFIGKAVRSFGRLTMFSDREGAMTQTLVATAPQVVEQKLSGQYFTPSLTWLGRWDYSKPDELKPHASDVAVQKKLWDVSQAAINDALKAAGMSLQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVL9</accession>
    <name>U4KVL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized zinc-type alcohol dehydrogenase-like protein YbdR acc. no. P77316</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_04944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVL9"/>
    <dbReference type="STRING" id="1076935.U4KVL9"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QNAMYGH"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX05357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="417" mass="45324" checksum="DBEBDB0470C8DAD4" modified="2013-12-11" version="1">MALNAASHLVEKALGHNTDDTSATSGIGNPARDNAAHPSGEKMKALAWMGKNDVRIIETDKPSLVDPHDVIIKVTGTTVCGSDVHLLHGQILQIKKGDILGHEFCGIVDEVGKDVKHLKKGMRVVNSFVVSCGECRFCVQKLTTACERTNASSLHDNLYGSKTAGIFGYSHFVGLYLSDVLVTSYHAVQDTAVYKGDTVAIWGLGPIGLLVAIFAFKAGASRVIGIDNNFRCDFAKKKIPGIEIINYSELPKGRTVTAEIHERVPGGVDCSIEAAGGEYAKGWAHSIELAIGAENDTSELLNEAIMSTRKFGRVGIIADYVGFTNHFNVGSLMERGIRLIGCGQSPVQKYWPEVLRMVESGEVDPSVIVTHRIRLDDIAKAYYMHEKKQDGMVKVFAETKFSHPKAEGIDQPDLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVP6</accession>
    <name>U4KVP6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative zinc metalloproteinase C607.06c acc. no. Q9US12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVP6"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YSIEIFC"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="466"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="591" mass="64305" checksum="32D650D5E751F856" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVS9</accession>
    <name>U4KVS9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_05325</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935269">
        <property type="protein sequence ID" value="CCX05738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVS9"/>
    <dbReference type="STRING" id="1076935.U4KVS9"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="273"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="471"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX05738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="635" mass="70044" checksum="E7BDA3B8E12ED508" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVX0</accession>
    <name>U4KVX0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVX0"/>
    <dbReference type="OrthoDB" id="5336512at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="43085" checksum="0563D2E2F383A9D5" modified="2013-12-11" version="1">MTSVIPSINFPTIARKISSTGKRSSRFLGLGQLRTSSSPKTTEDPTVLAETADGIIRLTPPDSDPTCDPSPQSCVTDAFNEETNWSNFKDNISISSNYDEEPKIHIEDEDEWMTYQSESCAGTEVTAVTASTYEDCVTRDSDTYSECESTVTETQWDGTVIDDCSTLPELVVPGDNHSNEDYGKEVIETIYVAQPMSCRIESVSSLDEYSEYMPVTPEFPPTPEPEEIDLDKDFVPRRPQRHTMLGVLRTGSFTSDDGYSGFRPPSFIQRHSKTDPITISRENMAQDWYETPPMKLDMEKLGELTPPTPNNKRMSTPPAPRSPSPLAWLTTHVSKAVSNRPRPPPLNLHPAFANDHLRDSPEDQGKSPDLKRARSPRRWSKMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVZ7</accession>
    <name>U4KVZ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVZ7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="6540" checksum="9E36782C435EB430" modified="2013-12-11" version="1">MFLSRSLQQSSPRISFLTSLSNPKPWHFPRCRYCNADARVHWTFYVCKLRTYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW79</accession>
    <name>U4KW79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935277">
        <property type="protein sequence ID" value="CCX05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW79"/>
    <dbReference type="OrthoDB" id="5440844at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="503" mass="57826" checksum="3DB27F008C81F3EE" modified="2013-12-11" version="1">MASPKSSPSANKTPIDHDYYGIEQQITADFEKIASDINEHVLEQLSKFRSNLCQVLQAKDVNEKKLRDENDELKKELAENKQQFEINNFIQRTMQEKIDKLWRRDEVFRATIIELMLANEKLQDMKLKDGMKYTDLIRIDEVLQEELNEWLKVHEKNVQEGVEKWMDENIKNIQSKMDLLRDNFTPMIKVTEAEQDLPQYSLKEPINQRDMTLNPSEIVQQLQQLNQKSTTETKSTKSEISKGRTAATTKSGDSDEKLTSANSPIEATTSKVAVTEKTFQQTKEEPKQKNAAIKPQLSPNNENNVKRMSSFYDERQKDLSNAILEPQRRAGTPTRAKGEYLKLSVKIAPKTTEFNLKMRKNDAESVHSGMGSSVRSKITELFDSVLPEVADEFGAFCRKTPLKTMPSGRVMVENLAGTDVAARYAYVRWEKVRQFEDLQRLMMCIWGQGLGPEPQIFYNDEPKGKKDWVKLSGKMANITLCPDETLAEDDPKYWKIQCFDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWD2</accession>
    <name>U4KWD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Pc20g05640 [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002563098</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_04988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWD2"/>
    <dbReference type="eggNOG" id="ENOG502RZW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX05401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="168" mass="18640" checksum="455C7E12E51A65F4" modified="2013-12-11" version="1">MRIFESLTRLLHLGFTTIALGLCGALLQQQYHGGTPTRLNYSIFALALSALSLFYLLPALFIERIRNPIAVITLDVLNFIFLFCAGIAMAAQLGGKGCGDRNHWRNGILNGGGYNPEKRCKEANALTAFLWFAATTAAISGIVAFYNMKKELDTRRLHSRRPNMKMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWE1</accession>
    <name>U4KWE1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative monooxygenase Rv1533 acc. no. O06179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_05764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWE1"/>
    <dbReference type="STRING" id="1076935.U4KWE1"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RAKPKAW"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="356" mass="37894" checksum="6528594FA8A493C6" modified="2013-12-11" version="1">MSGPITTEFTQLFKIQHPIALAGMNVAAGPKLAAAVTNAGGIGVIGGVGYTPDMLREQIAELKSYLNDKNAPFGVDLLLPKVGAGARATNYDYTKGKLSELIDITIESGAKLFVSAVGVPPKQIVDRLHQHGIAYMNMIGHPKHVSKCIEAGVDIICAQGGEGGGHTGDVPTSILIPTVVELCKKHKSPLTGKPVMVVAAGGIFNGKSLAASLMMGASAVWVGTRFILADEAGAPKAHQEAVRTAGFDDTIRTIIFTGRPLRVRKNAYIENWETARRDDIQKLTAKGVIPVEHDIERLDELDQLDDETMDNARPFLMGKVAAVVNDKKPAKAIVDEMVAEAVEMLKLGGTFLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWE7</accession>
    <name>U4KWE7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_05774</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="366" mass="42074" checksum="77E721517BD270A2" modified="2013-12-11" version="1">MPSRTTGISGTGTFQTIGAFSPFGSPSTPALDSLHPHAAVYHYPHPTLDLPAFFPLVCGYCPVQKHRCWPITPLMVHDSSCPIFPTQPDHLFRIADPHGLTRKSDYPPTCGLELKFPYQGDRVYINEESWRAGYQYPPLPREWERGNYRLRYRMPEIKLPEHMWRMLEKLYQNEEKRSGTGGNQRPREASERREASRGRRQESGPERLNTTKEPRAETRVTADDSDPRRLGRHPTASYLIPSDQSQSQGGSNAKLFGNLTRSKSTGPTSKPEPRELKGAKRGAPIPPVPRVPDKYRQPRDSRPRRDSMDEYAPDRANMDSETLRMAERYKLADIIQREGERKLAEDKAKDDRMRREKLRRTKSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX32</accession>
    <name>U4KX32_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX32"/>
    <dbReference type="STRING" id="1076935.U4KX32"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26369" checksum="BCB7042E0C34142D" modified="2013-12-11" version="1">MDPVTIGKSIIALIDAGQKVTNFISSINSAPAELHKLNLETATLRIVLRKLQDLFDDFNSSNSGDGTYQHRSVVTLEDLIIPITACLFSFEQLSKILFSPFLELLGSNESPSTVSSIWRSTLWVFKAKQVEGILSDLQRQQTSLNTMFSIFACKSLNEARSQQARLIHQNEELLTMRQEFASRIDMMSSIDPFQGTQTSSRHSSNSNVDDEGHATTPLNDEAFELGQPLLDTASIGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXA3</accession>
    <name>U4KXA3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935277">
        <property type="protein sequence ID" value="CCX05951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXA3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="22622" checksum="1C7CE04DCA792E4A" modified="2013-12-11" version="1">MSPNQPRPPAGQTEDQARSFIAINLIMNGSNTIDRNTALPVDNQPQKPPMSCPGAPSVAYRALPGTAVADDSFNHARTINAHAIDDNAARPPITSHIHETTMTCPGAPRLAYRQLSGVTVAPGRCNPKRTHVDRIENNATPSYETRILQGQNIYGMPMTYQGAPVAHRASPFTAIAPDSCDPGVSETLGERVVTPESSTPTDRAESESTGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZS1</accession>
    <name>U4KZS1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935346">
        <property type="protein sequence ID" value="CCX07255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZS1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="11101" checksum="C73B0CAEBFA18348" modified="2013-12-11" version="1">MFSNEMKTEAAENRIRSLKCFNYAHVEGHASQNLRFISELPSPFPAICLPILWLYERCITEITDIQKTGHRLPPGWYTYGWPQLSTGTRFAVRLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L007</accession>
    <name>U4L007_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L007"/>
    <dbReference type="STRING" id="1076935.U4L007"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX07360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="18496" checksum="AD2A94A3808E58E4" modified="2013-12-11" version="1">MAFRYLILLSRQGKVRLAKWFTTLGPKDKAKIVKDVTQLVLSRRTRMCNFLEYKDTKVVYRRYASLFFIAGIDATDNELITLEIVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQETSKKTVLRCIAQQDAIEDTEGEEEGLSRMIGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L093</accession>
    <name>U4L093_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L093"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="12295" checksum="8A71396D0A035C37" modified="2013-12-11" version="1">MSNFMNDNRRRSKTYSQHILNTQIPNNNHIFYQQNIMSSHAQVVPGYYITPPQDEFNNSFDAPESSQEALYPSSPYTGFEPVQSLESVQSLFIPSIPMTLSVEGFSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0A8</accession>
    <name>U4L0A8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Putative uncharacterized hydrolase YOR131C acc. no. Q12486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0A8"/>
    <dbReference type="STRING" id="1076935.U4L0A8"/>
    <dbReference type="eggNOG" id="ENOG502QR7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTYMFKE"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="289" mass="32096" checksum="5F9D43E72363B1F1" modified="2013-12-11" version="1">MRYFGGFSRFEDFVRFAAHINAAKAQYRNNMARSRPASTTRTLRFAPLNNNEDAVAGMPVFGGLSGLPAPQLAGIIFDVDGTLTMPQRWMFTKMREALGIDSKTDILHHVACLPEDSGAMELVEAVEREAMMKMEPSKGLLELMGYLENRGIRKGILTRNYEDPVNHLLTHHLPKTLFSPIVTRSFHPPKPSPDGILYIAKQWGLSDARNLIMVGDSMDDMAAGRSAGAATVLLVNDANKELGEHEFTDCVVERLDELIGMLESGFTERARNAEEIREEIQKVGEAMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0F7</accession>
    <name>U4L0F7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to unnamed protein product [Aspergillus oryzae RIB40] acc. no. BAE64297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0F7"/>
    <dbReference type="eggNOG" id="ENOG502SX3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSTIERP"/>
    <dbReference type="OrthoDB" id="2305901at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="439" mass="49262" checksum="8E193FE6D83B4601" modified="2013-12-11" version="1">MFNSTLPTVTLSDLLQYADAITRQAFANEVEYLDILSEDCKNHHHFLSIKFPKLIHVSIDGTDDNSSPDLYQQYLSPTLKIWQFYGGYLSDEFLLQLATSCPALEEVLIDNPRETLTATGFLSFLQSPYLKSLKRLIILYDMETVLSPEVFANLALHPGLEVLGIRHDEFPSLMSQCSGRPLFPDLKALDLSAPLECLIENSQKGHFPTLSRLEVLLKDPSEDFTASFGKQRLIDTTYPGKHAPLAELAAVFPNLEVLSIEFAEQTVTDIQLEDLAGMSERFKNLRELRLEGMDGALRGRDIGDQAVEALVKKAGKLEILRLQMTEMGVTDQGLRAVGRECGSIREVGLGGRFQLRLQLAGQKGVRFPALKELELGDVVDTGRGEEDLVRGLMEAAPELKDFRIEEGESEFASELRKLWRARREIERQDEDGEGEDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Y1</accession>
    <name>U4L0Y1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Y1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7714" checksum="1F0640719342EEA9" modified="2013-12-11" version="1">MADCRMSNYSPTANTQAENEKYEGDEHEEDKNEYEEGEEEDGQEEDEEEEDENAEEYVSDDPEPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L250</accession>
    <name>U4L250_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L250"/>
    <dbReference type="OrthoDB" id="3271094at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="16289" checksum="BF7C410DA1F515F3" modified="2013-12-11" version="1">MFLEQSRKNTESFILNTSSGKDRNESGLSFWKAKQQRMIKDIRKIKWSMFNAEDARILHQRMQSHVTAFHLFLTALNAQTQARTQRTTNQAAVTARNINDKVDKTLEVSLRTEKTLCEMVDQIKIIMGLDLPRNLGYAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2D4</accession>
    <name>U4L2D4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX09999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2D4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2104" checksum="AF39EBCF2716555E" modified="2013-12-11" version="1">MVRGALLSQPYTVPPSSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2R1</accession>
    <name>U4L2R1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein yddE acc. no. P96642</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935520">
        <property type="protein sequence ID" value="CCX10199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2R1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051162">
        <property type="entry name" value="T4SS_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121:SF6">
        <property type="entry name" value="SLR6007 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJGR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12846">
        <property type="entry name" value="AAA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="704" mass="79990" checksum="43683C9BF070CE42" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2W7</accession>
    <name>U4L2W7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative holo-[acyl-carrier-protein] synthase acc. no. G2TRL9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935493">
        <property type="protein sequence ID" value="CCX09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2W7"/>
    <dbReference type="eggNOG" id="ENOG502SDWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YMPFMEY"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="146" mass="16168" checksum="99DB2B324FAF192D" modified="2013-12-11" version="1">MFPNIGVDLLHLPRLSTLLVRRKPTYLARFARRILTDNELGTFTRKLGEGGGGLREDTVRWLGVRWAAKEAAFKAGGINRRLMWKEVEVRYLASGQPYLQLIKENVTGGLSISHDGEYVVAMAMLPPSVPEPVEAEGQEVAGAMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L358</accession>
    <name>U4L358_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Tubulin-specific chaperone E acc. no. Q5U508</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935574">
        <property type="protein sequence ID" value="CCX10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L358"/>
    <dbReference type="STRING" id="1076935.U4L358"/>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEESHMF"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="508" mass="56889" checksum="AAE2F8B238E5114E" modified="2013-12-11" version="1">MTDSFRINQRLSYDGALCTVRYIGKVGETKGEWLGVEWDDVLRGKHSGEHEGKRYFDCLIPGAGSFIRPTRKPDPTISFIEGLRRKYTTEFDAPRKEQAIVLTANKVFEEVGFDKIIQKLSQLQNLKIIIVDGLQIDRVDDIAVIRATCPNIEELDVSRNRFEKLEDIALVCSALPKLRSLRISGNRFNSLDVTDASGFANITSLEISNILMTWPELTQLLAYFPSVTTLIAPHNNLSQIPSPSPFPAPLTAVDFSYNNFSSLASLASMSELPNLKTLIASHNSITTLTTPPGTSFPALDRLDLAYNRIPTFSCLDELPPATPHLNSLRISHNPLYSDFTHDEGHMLSIGRLPTRVTILNHSTITTKERENAEMWYLSRIAKEFTASPERKDEILKSHRRWEELCKLHGEPAVGEDKSETEKTLAAKVFDMEFSYGGKTVRRRVPKGTPVSTLRGMVGRWFGVPVLGVRLKCCQEGEETVLDEVDDTREVGMHVEVGKGEVKVVVEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3J6</accession>
    <name>U4L3J6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3J6"/>
    <dbReference type="OMA" id="NAAPKLM"/>
    <dbReference type="OrthoDB" id="5415070at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651005" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="185" mass="17763" checksum="4DCAEFC17A31678B" modified="2013-12-11" version="1">MQTKFITLLLLSVSGALAQQDQPGLGDALSVVGTVVQDKAASFTSQVAADATSKIGADIASVTSGIPGAIASGTAHIGSDFNKATGVIASVGSKFSSVAGFSNIEDQLKSAIAQGTGAVASFLSTQTAMAGAAATSLEADVARAIISAATKTGGPQPTTSGNAAPKLMAGSAAGVVGILAVALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3V3</accession>
    <name>U4L3V3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3V3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="288" mass="34094" checksum="E8A0F654E0899043" modified="2013-12-11" version="1">MPRRPDPGFSNTYRQMISNLPKPATKYHYMLFGYKVTVLLPTNNRELAECGADGTLQALSTVTQSINLSRTTPDMDIDKRKIYQLTFMSYLQQYQNWGAEQDSQSPWPQLTEQMETHQRGARDLGIVDNNVFGYEDGFMAERFDRVMGYVERETLPLKNMYKQELKRRKKFYDEARAEIQRQFLWNEINEVEYEQEMYFLNDTEEREHVIGEWMNDSKWAMTLVYDALMDFYQKLQRDLGVHPDQLHPEKEEQNDVGEHPEEMDANVVKKEQDMSDSSMSDTLMRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Y0</accession>
    <name>U4L3Y0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Y0"/>
    <dbReference type="OrthoDB" id="5379279at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="605" mass="68366" checksum="00D5E4DC7682F125" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Y9</accession>
    <name>U4L3Y9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935331">
        <property type="protein sequence ID" value="CCX07023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Y9"/>
    <dbReference type="OrthoDB" id="10441617at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651016" evidence="2">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="14710" checksum="C74CE39E1E481437" modified="2013-12-11" version="1">MITLLNFTAHFHLLATLLALASFATQTAALPKSGRGGGDGSAGSGGGDSGIPSDNLTDGQIAGIVIGCVSALVLLWLGIAAWKSAKRKKTIEYERARIAEEGDSVPYAIIVQKQDAAVEAMKKKKKSRGHWLNNWEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L437</accession>
    <name>U4L437_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L437"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651643" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8958" checksum="FC5A2F71C6EB87CD" modified="2013-12-11" version="1">MHHRISRSLHSNMELVGMLLSRVAAVGARGGSCWSSCIELSIGETILLPFLSPNTPTSFRRSLIRCSIFHLSILWHQNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L717</accession>
    <name>U4L717_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935693">
        <property type="protein sequence ID" value="CCX12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L717"/>
    <dbReference type="STRING" id="1076935.U4L717"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="645"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="772" mass="86519" checksum="8D54E529F679E5D4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L726</accession>
    <name>U4L726_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L726"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651971" evidence="2">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="11126" checksum="A09646854F5086C5" modified="2013-12-11" version="1">MRFASITTPLLALATLTIAASPNIKTNDLTLHRHHQQNVIITPPTFTHEECHHLHGDKTMNASTSASPQRRRKVVKKTTSEETITARQIVGGIAVAVLVAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7N4</accession>
    <name>U4L7N4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08517</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7N4"/>
    <dbReference type="STRING" id="1076935.U4L7N4"/>
    <dbReference type="eggNOG" id="KOG0729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="213"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="49134" checksum="C034F43F8E63701C" modified="2013-12-11" version="1">MPSATGRDWEKYKKFADEEEEEKKIVPLSEEDIQVLKTYGAAPYAANIKATEKELKELQQKVNEKIGVKESDTGLAPPHLWDIMADKMRMQEEQPLQVARCTKIIQSADDPDKAKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRQKYQILLPLPPRIDPSVTMMTVEEKPDVTYGDVGGCKEQIEKLREVVELPLLSPERFVNLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPSTLDPALLRPGRIDRKVEFSLPDLEGRANVLRIHAKSMSVERDIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVANEKDFLAAVEKVIKGNLKFSSTARYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7U7</accession>
    <name>U4L7U7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935447">
        <property type="protein sequence ID" value="CCX09253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7U7"/>
    <dbReference type="OrthoDB" id="10622962at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="402" mass="46485" checksum="2FFD670C239B935E" modified="2013-12-11" version="1">MEQPENDSPRELSPREYFRSLYDFDPYEETEMFSSDWIFDRHGPLHHPTLHNPPAPETAAPDTTAPDTPRPDTPSHDTSSNYSDDDTSDSDFDETTPDTSFDPISSADTTVEDITANEFVPRITLSQPTLASAPVLPPYFTPSHPFSYTPPRPRHFSSPSPLVHQAQSSSRSPDRKYSCGFPACRARDEIRMKQKRLKLFTPESLARHYLHHHATLECKLQGTEKCKKAPWQRITHLHIAANGKHGKMTENETVWLMCGCESEFNWSDGEAVDLLNEWIGNGDCVAYERGEGGWVEWGMVQRKKQLDGRYMKGFKGRLKDKDREEMARARMEELELKTWSHIVAEGDEVDQKEYDRNKIAKAEVKLNKLHDEMENFVLRRRPSFRAREPKRRFYKFHFPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L860</accession>
    <name>U4L860_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Zinc finger protein 394 acc. no. A1YG48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_13919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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                <person name="Freitag M."/>
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</entry>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Kumar A."/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>U4L8K9</accession>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="620" mass="71962" checksum="FE1EC963782842AC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L923</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935302">
        <property type="protein sequence ID" value="CCX06624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L923"/>
    <dbReference type="OrthoDB" id="10678382at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="314" mass="33425" checksum="82320612DD243146" modified="2013-12-11" version="1">MQTQQQHQVQPRTILDSWIEIPSHPASSSSSSPDTSDAEIITAGLRISQRRRRHPRHRSLAETVLLSHPLDASFTSSYSTSSTSSAGDAGDDEADEADGVEDVAGYLSNLPLSSSEYDSEVCDESGSEDEIEEEFRTREREEMRVVSDQALRASLNTLLSCAAAARKANDPAVGTMAQIRERERESPLERSVEGLRVVQGSGPPAGVAAPTVQTVGSNRASKAGTGTASSAGSRTSSSPANSVTGDQSKRRKKSKKRQEVDLVMVVSLAAGAVVVVAAVGFAAFMAGGWVRREIAQDSVEAVLKEEARRLGVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9A7</accession>
    <name>U4L9A7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YBR271W acc. no. P38347</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935310">
        <property type="protein sequence ID" value="CCX06769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9A7"/>
    <dbReference type="STRING" id="1076935.U4L9A7"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CWWSIWG"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="39886" checksum="B5644804BC43251F" modified="2013-12-11" version="1">MATDLVSASEDNESPQYLHVLDLPRLYQRPSSAILEAVLQHFTLPPPSWDAPTSTASAPEGFEKWLISVISSPLSWMTDEEAELIRDSASERIAERCGRTARGDVKRTFKIPLPSRPSVLGSASSRLLEKLGESGSVTSSGASTPALVSGLSTPSASSGTSTPAATEQDFIEITLHEPALTSDTLGHKTWASSYLLSKRLHLLPPPSSRILELGSGTGLVGLSAAAVWGVPVLLTDLPEIISNLQRNIDSNLHLGIDCESQVLDWCDETEASEEEKYETILAADVVYEGSHPGLVAGVVGRWLAKGGRFVVEVPDRAGFEGEQKRFRECMEERGFRCQEEGREKGWDDWGSGGEAGQVGAWWSVWVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9X6</accession>
    <name>U4L9X6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936202">
        <property type="protein sequence ID" value="CCX15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9X6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="4725" checksum="D22DD819D74A99F7" modified="2013-12-11" version="1">MPDVLECGVVCALWLKSRGRLPKSPASDSSMHLPASSVQWDVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9Z4</accession>
    <name>U4L9Z4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9Z4"/>
    <dbReference type="STRING" id="1076935.U4L9Z4"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KMQYKND"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="180"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX16197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="486" mass="54030" checksum="29FB5E6348602A91" modified="2013-12-11" version="1">MASPAFDVGSGSGSSKAAAPSTAVSYHGFFSNRPCGYCKKNGGRSFYLQARSLTVSHYQSLVDRGWRRSGHLLYKPHMKLTCCKHYTIRLPTATFKPTRDQRQTLHKWNRFVLGEEYIMKAAKKWPLTREQKKKQQTFDLIETVHAAEYSTLEAAGRVQEDLKPEHKFEVTLEPAGFTEEKYALYSHYQQHIHKESVFEISKDGFKRFLCKSPITPSTTADGKKLGSYHQLYRLDGRLIAMGVLDLLPKAVSGVYLLYHTDFEKWQLGKVSACTEAVLAQEGGYGYHYLGYYIPSCQKMRYKATYGPSEILKPNDNTWTPLTPELQKVLEEVDEGFLITGGDGGVASGPSSEADAANTTMGPAGSETETANKTSTKDSSPSNPSSSQDEDDDEEEDNDPPSSPSDDEDDEDSPPPGFCLRSGMPGIMTPEELETFPLGELKIAIQGMEVQAKYLRGFHKEGVLRDVVREVVAVLGPVVSKEVVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA09</accession>
    <name>U4LA09_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative ankyrin repeat protein RBE_0317 acc. no. Q1RJR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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</entry>
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    <accession>U4LB76</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
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        <location>
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            <end position="1677"/>
        </location>
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        <location>
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            <end position="1801"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX15871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1803" mass="196529" checksum="E79792ED9BAD9D53" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4LC81</accession>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="262" mass="29494" checksum="CE17C1798AF82DBE" modified="2013-12-11" version="1">MQFISLQCDSCQHTDNFFPRMSPYCSQCTSNFGPSKAPSAAQMPADPSTPRTMTDEDLIQLFTRNMQFTQAAPPTPIASPTTSKFSVSQHYNHSSHYPYHPPSPPAAEMEMDDASSQLLAEQLASLQMSTQPQQPQQKTSDREYMEYLMSSDLSSPNSVNELEIALAHGIISAEEYQHAITAARRKQEMMNEEMLRNAGASRALGENCSAMDMLSAARREKEEQQQQWCNDYYPGQQEDVDDEEESPCSIYSAGYRLRPFDL</sequence>
</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="CCX29663.1"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDC0</accession>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="366" mass="39128" checksum="236282C009EDC910" modified="2013-12-11" version="1">MSKPGKVNFVITIRGRENFAYTSVYFAQCSQYLSAHDLSTNTAMSKAPEKRIAKQGSGCGRSSNCCCVVSAGAAKQKKPAKPNNPAKPNKPAKPNKPAKPNTPAKPNTPAKPDKTGKPDKAAKPDSTVKPHPKPDSAAKTVDTATPTTSSKKRKRTRKPRSNKPNTESTKAAELPPTPSTPKRVPVAITRVVEKTENPWPSSPPIKRLTDHIQGGNSFTSSPPTRRVGAHVLGNVIFPSSPPTIASSPPASLALPNHMATKGKMHPRSGRRNFKRARLEYLNSDALVPPVPDAAAATDAPVIEPVLDKGVLEDDDVALPPTYVTSMMSSNPLDWVDLHLITPTDPNGDAESSYLLSDDFLEPPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDT0</accession>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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            <dbReference type="EMBL" id="CCX30018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="94" mass="10436" checksum="F9585E1BCDC05595" modified="2013-12-11" version="1">MNNHNLPKALVQQVERLLRQNFPTANDEEIARRLEECAGPLQAIIRQRAGARIPPASCEADCCQFKCSTFARGFKDPGDSGFGCNKTTFPLQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDT1</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935446">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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            <begin position="16"/>
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            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
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            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="258" mass="26402" checksum="CC6BFE774133DC46" modified="2013-12-11" version="1">MAPEPRPRRSCRHRNSGNPNVNIPSGSPSYHNRRSNANVDVNNGQTSVSWTGDQGSTFNLNSGTGGTNVNYSSNGSGDDTDCSDDEDNHSSGGSGSSGYNPYSTSTSTSGAESLPNSAQLVKAGGDDGNKLAPIAIIVPVVVGVALLLLGIGFFVIWRKRRAAAREGSVEEASGENANAGSQAEMRGGEGQMTGTVIGLVGPTKYEIPPTYEASSRDRSVASSGEASEVNPFADPVVADGTRRGSDGSGGHNGRGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDX1</accession>
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            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDX1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8455" checksum="2B22A2765D0AE322" modified="2013-12-11" version="1">MFSSRVPVCMHFDTKHFPSPGNILQQAAHRWRWMTPTSSVNRQLAPVQLNPEASFTNSILIMEISSTARSETALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEF6</accession>
    <name>U4LEF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Demethylmenaquinone methyltransferase acc. no. Q9RRT0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935779">
        <property type="protein sequence ID" value="CCX13125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEF6"/>
    <dbReference type="STRING" id="1076935.U4LEF6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="28782" checksum="19D18991C5948122" modified="2013-12-11" version="1">MPTDEKEQDRRFEVDDAMLEWTFQEVRIRPQLERPEGEDYDCSGYDTSTASLSSSVHQYLFAHLRRYHAYYGPDKYLMPTDEKEQDRYVYQRLETAAPFILYNPATIIDRRYRLDLHHEMMRLLWNDKLHESPLDKPHRILDIGTGIGMWAIVMADQYAMAEVIGTDLSPIQADCRFEVDNAMLEWTFKDESFDFIHARNISGVSHWDHLVSEMIRCTNPGGYVELCEYSIKLFCDDGTMNPIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEM1</accession>
    <name>U4LEM1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_08440</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEM1"/>
    <dbReference type="STRING" id="1076935.U4LEM1"/>
    <dbReference type="eggNOG" id="ENOG502S1VT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSSHWGF"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651385" description="Autophagy-related protein 27" evidence="19">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX30298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="313" mass="35065" checksum="3E271602EEE9AC67" modified="2013-12-11" version="1">MRLPTPSRSAAAALLLPALVSANATPAWNCETTQNGLTYDFTSLAGKHELLTSEDTHPNRRNTTWQINPCGALPKPKDEKKLEECPAGSWVCALRSYIHPDGKADLAEVYPIAGELDDHKLDPNVTLFGSPDKTSGLRVTFHGAPNYLDHEQSAVIEFVCDESRTGLEGSEVVKESVEMLEEKDQPSLKFVSYVVDDTKEPKRQTLNLQWRTKQACEKNAKKGGSGDKPKEGNGDDGSSWGFFTWVFIISFLCVAAYLIFQSWLNYNRYNARGWDLLPHSDTIRDIPYLFQDFMRRVKETLQGRNSRVGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEM9</accession>
    <name>U4LEM9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEM9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="8031" checksum="E3CB5231F1911559" modified="2013-12-11" version="1">MGIDPHSSQTTRTCSWHKYPLHTGFFLTLSPPAPFFASSNHRQQLTGHGGRSKPILKYQRQNHRMSPQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFD0</accession>
    <name>U4LFD0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHE2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4923" checksum="E73C914D3225FC56" modified="2013-12-11" version="1">MCIFSPGFRNKPSSRFTFSVLIHESMMSRSGYAFRRKFTAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHY5</accession>
    <name>U4LHY5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_11402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="HF935648">
        <property type="protein sequence ID" value="CCX11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHY5"/>
    <dbReference type="STRING" id="1076935.U4LHY5"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="32841" checksum="818E97C9F1FC00AA" modified="2013-12-11" version="1">MATASYTTIPLLSLPIALLLCITFTLLYVSSVYLSSNTRPRPGLDRNAPHVIATRVRIASIITLLCTFLTSVLIFMITGQGWWAVLSLMGITHISPTTVWDTIKVLGVTGVLFIGPLAERAWEAVRWNGWRGLIPGVIGKKGRIGWVGWRNYVVAPITEEVVFRGCMVPLLMLAGVGAGRIVWTTPLVFGIAHFHHCYETILNHPSFISMAIISSLAQFTYTTIFGWWATFILVRTGSVWPAIAVHAMCNWIGAPAPKVSSRGWVNALYWVSLVGGAWGFYKLLWRGTESGEAMMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIS1</accession>
    <name>U4LIS1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_10784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIS1"/>
    <dbReference type="STRING" id="1076935.U4LIS1"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="112"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="509" mass="55825" checksum="94B1AE9437B42E45" modified="2013-12-11" version="1">MSAPAMVARCAAQRLATRTQPRAFNLRSFRTVTPAVRSPLSQSRSYVSVSARKCAEVEDVNRKIETQEVIRQTGMNPSGIDMGNGIHADAMMSPQAGILKQATVMDQGARPIYMDMQATTPTDPRVLDAMLPFYTGLYGNPHSRTHAYGWETEKAVDEAREHIANLIGADPKEIIFTSGATESNNMSIKGVARFYKSKKKHIITSQTEHKCVLDSCRHLQEEGFDVTYLPVMSNGLIDLEELKASIRPDTALVSIMSVNNEIGVIQPMEEIGKICKANKIYFHTDAAQAVGKIPVDVNKWGIDLMSISGHKIYGPKGIGACYVRRRPRVRIEPLISGGGQERGLRSGTLAPALVIGMGEACRIAQEDLAYDHARVSYLSKRLQDGLLAMEHTTLNGAADARYPGCVNISFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGSSDESAHSSIRFGIGRFTTEEEIDYVLKVVEERVTFLRELSPLWELVQEGVDLNTIQWSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ70</accession>
    <name>U4LJ70_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ70"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7781" checksum="7EF290AFE2333993" modified="2013-12-11" version="1">MFFDSAQLTAAGRRRRYGIVRRKEEREVTERRKSRSKEQSLSSISLIPPSVQSAEIEILDAEQTQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJB9</accession>
    <name>U4LJB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJB9"/>
    <dbReference type="STRING" id="1076935.U4LJB9"/>
    <dbReference type="eggNOG" id="ENOG502QU12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX17440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="680" mass="75440" checksum="A5D5705FEA99E320" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKG4</accession>
    <name>U4LKG4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKG4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4306" checksum="F2F72407AE80F246" modified="2013-12-11" version="1">MECRPNDPITNQKAALHGQSIGLWLGICNQYSSPRMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKJ8</accession>
    <name>U4LKJ8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKJ8"/>
    <dbReference type="STRING" id="1076935.U4LKJ8"/>
    <dbReference type="eggNOG" id="KOG1197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGMTAHY"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="60"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="376" mass="40866" checksum="0F365378B4D08247" modified="2013-12-11" version="1">MMLVFPAAARATSYISRSPAPSFIRQSTVFRSIKRYPFKLNYTTMSIPTTQRAVQINRTGGPEVIEINTAAPVPTPNDNEILVNNQFAGLNYIDTYFRSGLYQPSPYPYTLGREGEGHVVAVGSNVTDFKVGDRVAYTGPNTQAEYTVADPNKTIKIPDEIKPGVTVASMIQGLTALTMIRESHLVKAGDSILVHAAAGGVGLWLCQLLRIVGAGKIIATASTEEKLELAKANGATHGINYTKEDWVAKVKEITGDQDEPGVIAVFDGVGASTFEGDLEVLSRKGSLISFGNASGSVPPFAIARLAAKNIKVMRPQLFAYIAKKEEFTAYANELLELLKTEKIQVRIHETYTLEQAPQAHKDIESRGTTGKLLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKM4</accession>
    <name>U4LKM4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKM4"/>
    <dbReference type="STRING" id="1076935.U4LKM4"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KVYYMFG"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007365974" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX29910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="639" mass="72322" checksum="CFE91E280ABC9B39" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLC8</accession>
    <name>U4LLC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Alpha-ketoglutarate-dependent dioxygenase abh1 acc. no. O60066</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLC8"/>
    <dbReference type="STRING" id="1076935.U4LLC8"/>
    <dbReference type="eggNOG" id="KOG2731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHTHYTL"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="215"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="329" mass="36060" checksum="46D6026ABE8EB9B6" modified="2013-12-11" version="1">MHSTESSTAPPPPPLEHAHHQPPPHIKAFHKLAQKTPEDADILDFFTGAVSDHHRSRLKQHATISGTTAAEVFARFSGKQNTTDPVADIPIYTHSSVPGLLIVPNLLPIPTQQHLLTTLLTGALSDTETHKTNLHTFYSIPSPLPWFSEPPTTTLLPLTDIHKPLTLSQALTKKLRWMTLGGQYDWTAKRYPDSLPPPFPSDVAGLVNGLFPDVTAQAAIVNLYSPGDMLAPHRDIAESVGKGLVSISVGCSGVFVIGCDEKEEVLAVRLNSGDAVVMGGESRWAWHSVPRVERGTCPEELAGWGAGQEQWKDWMRGKRVNVNIRQMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLL8</accession>
    <name>U4LLL8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935945">
        <property type="protein sequence ID" value="CCX14278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLL8"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX14278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9419" checksum="46DFA1C6246C866B" modified="2013-12-11" version="1">MPITINAVYTSPNDTNTFVISTEAAAATEDSTQADQTNHVKAVREAVAKLQDRVNKYLTERMEVEKNDAAKALEDNYGEEVVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM26</accession>
    <name>U4LM26_PYROM</name>
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        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">PCON_14362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936044">
        <property type="protein sequence ID" value="CCX14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36348" checksum="21F3E2F00EFFF96C" modified="2013-12-11" version="1">MSSSKPENLGSNLEVDPAVLEDSVADSYDSSGFCTSTESLTSSINQYIFENGRRYHSYYGADKNLMPTNETEQDRLDLHHEIMLLLLEGKLHLAPIGPDPQKILDIGTGTGIWAVDCADIYSNAEVIGTDLSPIQPSWVPQNLKFEVDDMTQEWSYKDVYFPPIGHSRFGSYRCLKPGGYLKIAEMEFGTFSDDDKIDNGFRTWMEYLEEACEKLGRPTITAERVKQILNDGGLEGIQVATMKQPFGPWAKDERMKKVGTMTMFTADSGSTGYGLALFTRVLDVAPEKALAVCKAGAADTKNKNYHMWTPFHVAYGRKPISADYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM58</accession>
    <name>U4LM58_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM58"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4169" checksum="522846D21C4E170D" modified="2013-12-11" version="1">METAPEQCGLGVVSFIFRFLPFLFGSKFECPLLQRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNM7</accession>
    <name>U4LNM7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative aminoacrylate hydrolase RutD acc. no. Q7CWX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNM7"/>
    <dbReference type="STRING" id="1076935.U4LNM7"/>
    <dbReference type="eggNOG" id="ENOG502QTP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETTHHER"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="356"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="685" mass="75119" checksum="6B10A7F457E1372E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNT3</accession>
    <name>U4LNT3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNT3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8368" checksum="4AEA6732620DDB89" modified="2013-12-11" version="1">MTSTTKQSYSELETRGARGERGSRIATAIIRNLAQNIRDKNCRTHHLRGRRHDGRRPNFRVSVCERIRGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNZ2</accession>
    <name>U4LNZ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNZ2"/>
    <dbReference type="STRING" id="1076935.U4LNZ2"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTIFAMA"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="219" mass="24464" checksum="209AD92FBBFA5C9F" modified="2013-12-11" version="1">MLAPRIFNFLRGATPVLSALRSGIVAPVKTALPALPKIQARNASHATAGRANKAKDGPGKRLGAKLTQGERVTTGMIIYRQRGTLWYPGENAGMGRDHTIFAMAPGTVRYYKDPAHPKRKFIGIALNEKQKLPKPPNAARTRRLGMKTVPLVEEAPKVYGVKIQKSDLEAKDGFYVHRPPNWKIGRIMPKVNIKNNNPFARWQKKGKRNLAYRRRKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP85</accession>
    <name>U4LP85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to O-methyltransferase mdmC acc. no. Q00719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936182">
        <property type="protein sequence ID" value="CCX33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP85"/>
    <dbReference type="STRING" id="1076935.U4LP85"/>
    <dbReference type="eggNOG" id="ENOG502RZAN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSMKARF"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="228" mass="25565" checksum="52B0F284027A30C2" modified="2013-12-11" version="1">MPPQSPIIASSAVHSLLTRLHAESTKQEQTWSHYLFNLRRQFFGATLESVDAFMGDKFVALEPEKCHFVYLLARSMGARNIVEAGTSFGVSTIYLSLAVGQNGGGRVIATEKEGKKAEKAREYWKEAGEEVEKHIELREGDILETLKEGVGEVDMLLLDIWTPLALPVLKLVKPRLKKGAVVIADNTTQFKMPYREFLEYLDQPENGLKHMTVPFSNGLEVAVYLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPX6</accession>
    <name>U4LPX6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936505">
        <property type="protein sequence ID" value="CCX16720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPX6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="6984" checksum="999396EFDA0EDEDC" modified="2013-12-11" version="1">MSCCPRIPVVDNAAALPGDKCHRHHLALEVLLAPAQYVTWSNVITRCFRSHITACLDSLAKPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ29</accession>
    <name>U4LQ29_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="HF936576">
        <property type="protein sequence ID" value="CCX17127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ29"/>
    <dbReference type="STRING" id="1076935.U4LQ29"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LGNCWFR"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX17127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="520" mass="55366" checksum="3351B7A3F87B874F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQS8</accession>
    <name>U4LQS8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQS8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="154" mass="17154" checksum="BCB3415CC695777D" modified="2013-12-11" version="1">MASELVSPDTVSPRILSTNTRSNRRLRLARDSRELIGPPSLPSIRIQRHAVMTLAMEIDSRTAPHFTSVGLHADIAFGLHRPLRGGCDGVISAHRRCHGIPKPQFSSTDALLTLFRVLFLFLCQRSAWIRNQSDLLPFDALDPINTGRHFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQV8</accession>
    <name>U4LQV8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQV8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="241" mass="26034" checksum="1CF335CFD30A7286" modified="2013-12-11" version="1">MPGKQNDEITRRRKRRENKEARERDIPEPHIFRPRKNSKAAKAAVAAEECPSLTFTTSEAVEALSTDNTDTDNVAASTFAPEYDQAGIPTAISTPDFEYQNGLLATTLASTPTYVDTPAPAPVANGNLVYGTEMDVDDQEIVLEHDNNVGVQAAVEEWLLTRNVPATAVGSYAIALSSTPFAAEDNAPNNEHFGAIEFQAHQKAILVFPHLEAAAIALANGAHAATDDDEATWLEKLMSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQX6</accession>
    <name>U4LQX6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Transmembrane protein 19 acc. no. Q96HH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQX6"/>
    <dbReference type="STRING" id="1076935.U4LQX6"/>
    <dbReference type="eggNOG" id="KOG4491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSSFACC"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652575" evidence="8">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="347" mass="35491" checksum="82E6E214781CD0C4" modified="2013-12-11" version="1">MNPLLFFPALALLVVRALQRNSLTPAGILAAIVTAGVHGYHPSALPFTLLITFYTLGTVATKVKHDVKSRLTISSTGASSTARNATQVFANSIVATVLTAAHIYTGEEVYLIGVVANYAATTADTLSSELGILSTSQPILITTLRRCPPGTNGGISLFGLIAGAAGASVIGAVSSLLLRLPLLPLQAESPLTPGGHALATSSALGFTLFITITGTMGSLLDSLLGAIAQESVVDTRTGKVVEAPGGGRVLIEPNVKVLSPVGKMHSKLGHAPQGAGEAVGVVGDEGKAAKTAKGKKDTAKAEGMEGKKEKEEGSRKRIGGSGWLTNNGVNFTMALLVSLGAMGWWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR12</accession>
    <name>U4LR12_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR12"/>
    <dbReference type="eggNOG" id="ENOG502S2BT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="160054at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652581" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="10857" checksum="81F9B0F1B489D7CF" modified="2013-12-11" version="1">MLTLRDLVIIAALALTASATLNPATSNTKGKCPSEYNCSGIAYTCTAPTSAQMTDVDEDCWTFFWGSQGEETGYGTTCIKDPTDGTCGCENSDGTFVKGSSSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS64</accession>
    <name>U4LS64_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935728">
        <property type="protein sequence ID" value="CCX32185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS64"/>
    <dbReference type="OrthoDB" id="5423239at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="443" mass="49385" checksum="2EDA869CF68A51A3" modified="2013-12-11" version="1">MVRTTNVNEGIGMEFYLKIIDPGRDAMFSRAYQQYESKINTFLASLFSDRGYPSGGRRQAPLKYGNHSVVEQEVVQVSFRLAPNANNVSLCEAAESFCEAVFAKPESLGNLTVRGLLGVEPEGELIQKQWYRAMFRAVLTDGKPLLKALEAGYQHPLLVDWALTLCFCIVAQVNCRAVTEQETGEFSEEAVDLAEKILNKFFDKNTASPPSADVDLNKVMDDLVARLRSIVATNPRSLALGIDMRLPLFSAAHAAACVLVSNREIFKEFIRRRKIAAKKLAAGNVFLHASAVAHHSTRDLLSRETAGDFCSSKLVEEPTTRRKFHPAWWAAAPIVLPFAMAGGVFYGPYKLGQWASQEQFEKRLTGVNELAVFVARAFGLALDIRVMLGWIHWEREALVSDQAKEMCRALLGSDKGLHGIVKYLREQGEGLETWRELLDVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSA7</accession>
    <name>U4LSA7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Heavy metal tolerance protein acc. no. Q02592</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12563</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935733">
        <property type="protein sequence ID" value="CCX32225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LSA7"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTHENVY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="310"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="627"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="890"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="897"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1175"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1185"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1291" mass="143227" checksum="9062D4869C8B0FF5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSM4</accession>
    <name>U4LSM4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Spermidine synthase acc. no. Q8D3Q3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSM4"/>
    <dbReference type="STRING" id="1076935.U4LSM4"/>
    <dbReference type="eggNOG" id="ENOG502QTVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFIGWAG"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="572" mass="63429" checksum="ACA701275BC78550" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSP2</accession>
    <name>U4LSP2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCX32425.1"/>
        </source>
    </evidence>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTB9</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
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        </source>
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        <location>
            <begin position="203"/>
            <end position="222"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="456" mass="48698" checksum="8FDF9FBF53D60FE7" modified="2013-12-11" version="1">MTAGSAGEGGGIVGGGRVGEQGASAEGTQRASPGAPGASGASGASGASEASGASEVSGASPGGISATLLGVPGAASAAAGAPGISSIVPRKTSGQDPHNNGARAALTNEIRTEFFRLYENADFEIPGLSPQNILRHKDKDLYFEGHDGLKDFWKQTAASRREILQLAREGKIRVLRGPNGGLISTLPIPSHLDSIIAADRSTSVSTSSDDSISGSASGSSGTINSALLDSRKRNHDIEPAHTSKRQQQTNGITLTPHPNHTFSFHPSQEAQSNSLQSQYWDRTTTMNSSSTHPSSLTHSNPPSDHRNSSSTSPPAASNPAAIAVLLADLQAAFQEYDINLPSNHALHKLKDERDRALERAIRLERERDEALRARDAALKLAEESYGELRALMDSRARRIQELRDVRDIGRRQQVNEGVQEAQRMEDNRRMGERERERRREDAMGDRIMGNGGGEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTC2</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </reference>
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        <text evidence="6">Belongs to the cullin family.</text>
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    <dbReference type="STRING" id="1076935.U4LTC2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF08672">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF25773">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="670"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="965" mass="109105" checksum="7D2C039A69632F53" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTG9</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="OMA" id="NRTPLYW"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="430"/>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF24883"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32835.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
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            <end position="156"/>
        </location>
    </feature>
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            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="172" mass="19709" checksum="1E8D112F8DF57572" modified="2013-12-11" version="1">MYIYFWPLENHVISIDAWNLTFFLPEALLFYLRFILIVFKEVLPYAPIWEQSSKLDNWCTRLPEPVSLQSLLVASMNCLRNGGIWDPLNNLKNFGTGLQNLWAGLKIRLDPSENMADTMIKLVAGYPEPVKDAKRESKDPQPTENTPVLQEGQSQAEHLEVEGCARKDEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU97</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="339" mass="39479" checksum="CE92ADB0EB1091D6" modified="2013-12-11" version="1">MGNNISNTRHRTGQHHEHGAFRRRLSYLKIIFTERHGNAQSAPESDDEEHEKEDPELPVSIEKPHQLHHIPLSEKDWLRFKNDVFERLREDGKDPDEMLSIYWLGMDVKEHEYRVLPAKELLLSKMELAGINPEEVLEDGWMDRVNDMEDFDFRMIVSMKLVDQLLGDDTGDTSTKLWAKLMDGDKTTKVLMEKYSILKTLVDSVAENDSVYSAPQDLGDEYVASQKRLGDTRDAFEVILGCVKDMPAKFGDSYEGDNHLLRIHQDRRKFEKKTYRLWRFLRDCYDPENSATRKEPRFLAGVGNTTVFAEPWREEVGGRIIKVQMVEAEQAKAAEYFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUM9</accession>
    <name>U4LUM9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935650">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="780"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1266"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1354"/>
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        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
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        <location>
            <begin position="1047"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1454" mass="164602" checksum="4A3A4F1EF9667280" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV85</accession>
    <name>U4LV85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Tropomyosin acc. no. Q02088</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935809">
        <property type="protein sequence ID" value="CCX32306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV85"/>
    <dbReference type="STRING" id="1076935.U4LV85"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="18518" checksum="E27031DF95CF9A53" modified="2013-12-11" version="1">MDKLKEKMNSLRMETEAAQAQNEELQAKIKVLEQENLTKEQEIASLSHRNTLLDEEVEKLEKALAEAKTAADSGASSSAELDALQRKLQLLEDEAEEADKNLRETNEKLRLTDVKAEHYERKVATVEAERDQWEKKYEEIVEKYKSAQDELDKIAQQLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVC4</accession>
    <name>U4LVC4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVC4"/>
    <dbReference type="OrthoDB" id="10330667at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22884" checksum="6699B7792EC22EB9" modified="2013-12-11" version="1">MHSLPSFIEPPPHLVLLDALTTLYTGYILVDGVWRLLLKTTDIGGLLRYRTPRFTALLAAAILYAGLTWQVYGDGYWRGSYRMLQIADATAGRKILFEWMKVVLLGRGVEIVEKRWTGNYKGAGRRVRDKKMVYVDNDEEKKEKPKLGDGMAGPVDEIRRLREERVKKLEAEAAARKKRAGKRVELSETAQKVHNLARDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVD8</accession>
    <name>U4LVD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVD8"/>
    <dbReference type="STRING" id="1076935.U4LVD8"/>
    <dbReference type="eggNOG" id="ENOG502QU9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SPYWCCK"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="271"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="532" mass="60125" checksum="1F58C4F2E799F438" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVV7</accession>
    <name>U4LVV7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Glutathione S-transferase 1 acc. no. Q9Y7Q2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVV7"/>
    <dbReference type="STRING" id="1076935.U4LVV7"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATQYAKH"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="224" mass="26400" checksum="F8746563108EC9AA" modified="2013-12-11" version="1">MSSPQFTLYAHIGPNPWKVVFLLEELGLTYKLAHVDTSKNEHKEAPYVLLNPNGRMPTLVDHHNNDFAIWESGAIMLYLIEKYDTQKKLSFEKFESEALAKQYLMFQMSGQGPYFGQAVWFEVYHPEKVPSASDRYMAEIKRIVTVLNTILEGRNWLVEDKCSYADLSFIPWMWLFDWPVMKMSNWREVPEYKNVVRWYDAMEAMECVKKTKEIRATEFKMPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWT0</accession>
    <name>U4LWT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWT0"/>
    <dbReference type="OrthoDB" id="10420239at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652704" evidence="1">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="179" mass="20231" checksum="FF12C1060D075F35" modified="2013-12-11" version="1">MLLHQILTLIFAYLVSSQSFTLSSSRTNQIITISSSNSTDFPRPYLQLSPAYVCPTVFSFDSSSRNITVASSAFPSSLTKKNLYLQKPTKYDPILTPYVGDIDFWLYAFWNTWEITKDGYLRIGIWGRRAEDKRWFACSGGDDKGLEGRVWHLDFLGSKPLPCNGSNFDLRVNFGSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU16</accession>
    <name>U4KU16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein acc. no. Q69ZK0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU16"/>
    <dbReference type="STRING" id="1076935.U4KU16"/>
    <dbReference type="eggNOG" id="KOG3518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSATIMR"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="252"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="940" mass="105259" checksum="9D971747D7B0A592" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU29</accession>
    <name>U4KU29_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to General amino-acid permease GAP1 acc. no. P19145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935201">
        <property type="protein sequence ID" value="CCX04382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU29"/>
    <dbReference type="STRING" id="1076935.U4KU29"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMAFIPD"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="72"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="588" mass="63478" checksum="1C782E6219755D5D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUJ0</accession>
    <name>U4KUJ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUJ0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="38537" checksum="F730983EBF8BA4A5" modified="2013-12-11" version="1">MAPRYGPAAHQYDPARRQYITPAEVSTFHQAVVDTIRRSSRKRCGRKPKVHKKTLSTMFWHSRRARWSATDSQLVAAKQEQDLSRGQGRIYGIKFKRCSSLSDAIRPVLDGLAAITNGLTDFTDDRVYTLRHLMEFQRSFREFLTRWTKYDFDLWLWQGDSGKLEDFYDSGFEDCEDDCENIDGYDYGVDGTLLLNVADITLDPSVNVAEAQIDAETTSSAPPANETQTNTDKAPSTPLIVNGDTTTGDNLSLDSLQDPALKPALPAVNLLAGLLAYSENFKNKFVDFNIARIFQQTIIANLTDDWPYLENILMNLYQFEKSLSDHIVKRQTAEKEGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUP8</accession>
    <name>U4KUP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUP8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8558" checksum="E50DC3569FEC4EBB" modified="2013-12-11" version="1">MAFLEERNDDKLDKRSVMSYFIFRHQQCSSSKVIANVQRALEHLEKLLQQQYSNDSTCQHEFCFPWSLSANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUQ7</accession>
    <name>U4KUQ7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUQ7"/>
    <dbReference type="STRING" id="1076935.U4KUQ7"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GTTVQTC"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651086" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="539"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="701" mass="76042" checksum="7198DBD3E4DD8834" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUS5</accession>
    <name>U4KUS5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C3H8.04 acc. no. Q10140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUS5"/>
    <dbReference type="STRING" id="1076935.U4KUS5"/>
    <dbReference type="eggNOG" id="KOG2306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSHEPTH"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="282"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="573" mass="64168" checksum="BB4AE7BEC40E175A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUX7</accession>
    <name>U4KUX7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Phenol 2-monooxygenase acc. no. P15245</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935220">
        <property type="protein sequence ID" value="CCX04912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUX7"/>
    <dbReference type="STRING" id="1076935.U4KUX7"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWPTLYD"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="82"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="553"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="698" mass="77978" checksum="DEB445EC10A3A50F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUX9</accession>
    <name>U4KUX9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Uncharacterized WD repeat-containing protein C17D11.16 acc. no. Q9P775</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUX9"/>
    <dbReference type="STRING" id="1076935.U4KUX9"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="559" mass="61879" checksum="FE4F30D1C26DD3A7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW23</accession>
    <name>U4KW23_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW23"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="12725" checksum="F132D922424A15B0" modified="2013-12-11" version="1">MVCSNHVPPSHLDLSTDRYFSVFKAHHNDTEIPWGAWLRELFTGLRTPTSSYSRGSLAPCPGGPGLQIHSKGISLSCLSSLGPLPHIIGRAAPFSSFGAACLDSWRAAGSFPRRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW62</accession>
    <name>U4KW62_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Cell wall integrity and stress response component 4 acc. no. P38739</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_05249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW62"/>
    <dbReference type="STRING" id="1076935.U4KW62"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTHIILH"/>
    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="7">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="419" mass="44507" checksum="776ACCEAD2E608A1" modified="2013-12-11" version="1">MVQRAATRVRGGQNQPPTTDRAKQQRYKLWWMSGGNDGPVGYDLHVLIDLQRRTHIILHMDLQKVYKLSPLPRALIGSGRGQNYDRKKKSGIKRWLTLTVVAFAVSSIPKASADTKYCSKVNTGDGDGTSSTFQSIGLCTTQCQSDFAFAVLQGKYCWCSNYAPSTPSDGTCDSPCPGYPADQCGNLNDNLYGYIQLPNKVLGTKGPASSTTSINSATKSSSAPSATSTLQTITTTAATATATNTSSPTSTAAASTDNASFTSSPGKVAGLIVGLIIALLLIVAAVLFWRRRRNQRDSALYGSSQNGLISAGGAGFFGGGRRGRSMSTLGLVGEKSPPSSQSTPPVLDANGVAIAQPPRTAGAPNGTITEGEAYDQRLDPQSLFMKFDPHTGSSRMSVRSLRDDTDYSRRVLRLANPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW71</accession>
    <name>U4KW71_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW71"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4730" checksum="B5AF6378BDDE4104" modified="2013-12-11" version="1">MFRLKSSLPCYFSLSPCLHWYTVPSSPIRFDHSMFFSVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWD6</accession>
    <name>U4KWD6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PCON_05754</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CBS 100304</strain>
            <tissue evidence="26">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWD6"/>
    <dbReference type="STRING" id="1076935.U4KWD6"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESEPMYF"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="439"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CCX06167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="700" mass="75667" checksum="E7B06D13B6988538" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWU5</accession>
    <name>U4KWU5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWU5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="31" mass="3794" checksum="F7D02C77417DED48" modified="2013-12-11" version="1">MYLGHLGLIIQRRIKLMTLFLYNTWLVWNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYP0</accession>
    <name>U4KYP0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYP0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="32293" checksum="72F74FF9FA30C28E" modified="2013-12-11" version="1">MYKIFLQRLPHVVLLLSTDRTVGEDLLSGLAVLLGLLLAGDTVEGCLLLDVQGDACIRQLQHINSSSSSVVQTTIKRTPSNPSLRNVHLLALQPLSKDRLIPSVVKVLKDTLCRLLWREAHLNNSILNRLSSNLSSKRRKLLHRSLNEVRSSGMFPLGLSDLLLPRQSSSLPVIPLRNLLQPTPVVSFRIPQFPKSFKVDKLAVYSGRLFLLCEKGRIRKISTLRYFLGCRGSAGGSLKKLGDASEFRVGGGFGGFGRFLGGLGSPVEAEEGSSSQGNPGRWDEHAEGGEGGHGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYP5</accession>
    <name>U4KYP5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935312">
        <property type="protein sequence ID" value="CCX06780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYP5"/>
    <dbReference type="STRING" id="1076935.U4KYP5"/>
    <dbReference type="eggNOG" id="ENOG502S1B4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQDGRSW"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="76"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX06780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="41961" checksum="98E6EC19CE7FCCCD" modified="2013-12-11" version="1">MSLNMYSIAPGQHHNQQHQHQHQQHHAGVPPPPLPLTRASSSTSSSQPHQPPPHPINSNGMSQNYPPLPQNVSCRGDGRIYSLEVKQQPIRARMCGFGDKDRRPITPPPCVRLVVKDEATGKEIDINEVDTSFYVLTVDLWSADGSREVNLVRHSATSPSISAATSSSYPPPPPTPPPHPHPQAHHPHHPQQQHPGYSQITYQGYPPAQSPHPPAQQQPPAPQGYQPYPPTQQQPQNGPGYGGYQNTMQVAAASPQQQMPSGPMPPQTPSGMFTRNLIGSLSASAFKLTDPDNKIGVWFILQDLSVRTEGLFRLKMNFVNVGRVDGKLNTGVAPVLATAYSDVFQVYSAKKFPGVIESTHLSKCFATQGIKIPIRRDKGDGPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ00</accession>
    <name>U4KZ00_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ00"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21598" checksum="CDF081EAAD808EC6" modified="2013-12-11" version="1">MSDRLPTDDEWSKSTDEEWSSSTDEDYDWEAMVQEVAPSDENTQISPGQHALWDCVPQFPDWMKKKLESPFPLEKLPSEILYIILQHMINEDYESIQALKTPRYSGIKICHRCRGPWDSLYGLLPNIFYAAPQVLAFSQLSKFTRELVINEAKLNPKIKEIMTVSHSVIKNHNLTFNMRHKLGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZI7</accession>
    <name>U4KZI7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12156" checksum="CB4BF06F890A026B" modified="2013-12-11" version="1">MRELRELPSLLRGLLVRELASPPSVTPVSPNVLRVETGACRLMLASEFAHPSPHSCGGSFHNWAKLATGSARESIAAAMFSLGLGTVSSETDFSSCMIISHIYSNGASLLKQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZS0</accession>
    <name>U4KZS0_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX05209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11555" checksum="059AAB830ED1E418" modified="2013-12-11" version="1">MLLHHAGSMSSCGCFKNLHSARDIEQRKINQWTTPAFTQLTSGYPDSIFEISPGLSQVKYSQTDRVINEDLALPSYPLAILETNECGTTKCCCVVQIQFQDVIA</sequence>
</entry>
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    <accession>U4KZU0</accession>
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        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the calmodulin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="Calmodulin"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="16997" checksum="391C14BA2C533A89" modified="2013-12-11" version="1">MADSLTEEQVSEFKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L048</accession>
    <name>U4L048_PYROM</name>
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        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SC5V">
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
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    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX08329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="449" mass="48593" checksum="B97BA1AD1AD39B64" modified="2013-12-11" version="1">MHRRCRKPLLNKVRKPNGSSVQNDTTALRERLLSHVQSPPTTAAPANPTPAPPATTAAPSTTRENIDPAMTNQASQQQAQQAAEQAQQQLQAAIQQQQQLQQAIQAQQQQQQQQPLQQAQAQVQQAQAAHAQAAHAQAQAQAQAQAQAQAMHAAHAAQQQQPPSQPHNIIPSPTMTPGQTMEQLSPGADDSEQPKARGGKRELSTSKRAAQNRAAQRAFRQRKEGYIKKLEEQVKEFTAMQENYRQIQSENYSLRNYIITIQSRLIDVQGEDGIPPAPDVLNNPTPALPLIDTSGSSPVVQPQAGPGRPPSVPVIGRPASVLVMPQHQVLQVPQGVPIAPASPHQQQQQQQQQQQQQQPVLSEIMAAVGQKRPHDETDQAFLQSIAQAAGGPAAGFIPVQAAPQQPQQQQQQPTTPIPVQSPQKGKSQSPAAKRVKGEKAAEKEAMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0J3</accession>
    <name>U4L0J3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935426">
        <property type="protein sequence ID" value="CCX08628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0J3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="50" mass="5408" checksum="87A7F0E39A0B5AD1" modified="2013-12-11" version="1">MPSRARGRCTTSSTAVATSTTPIRVCTRGLRDTFSSLLLDHNSKRAGSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0M1</accession>
    <name>U4L0M1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0M1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8837" checksum="7C9D0FBF1BA272EE" modified="2013-12-11" version="1">MEEDRGYLHSNGSSIHNQSILHRFPSSIFSFPMTPDVEISVNTSYHTSTLSHMFAFRCQRGRIQYLPTTGFKSDNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1K1</accession>
    <name>U4L1K1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1K1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="169" mass="18611" checksum="90676EEA1FA55C7B" modified="2013-12-11" version="1">MKVINGKSSRCLSIDCRQSRFALEYRADGSETSRYNGILASTHPYHTAISITTAVSIPCRFESKGPMGSAFLGCLPHTDMEKLFGASTAMMRCVRFASVIRLRGIAESQRLSARSPAEELHKSKIKMVARDPQSAAAAAVRRHLTLPTFFTGALTKFFCKILTTFQNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2D7</accession>
    <name>U4L2D7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2D7"/>
    <dbReference type="STRING" id="1076935.U4L2D7"/>
    <dbReference type="eggNOG" id="KOG3909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEKFARI"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="511" mass="56413" checksum="E14FE681CB9603DE" modified="2013-12-11" version="1">MTVSEDIEASVHPDNSDISATHHSAMFSFKLLTTSPQAVTTGARLGQLITRAGKIQTPNFIAPSSRGVVPHLSQDNLRDHTKIPGVYVATEDFIEKPLPSIFDQPELSQHNNNTSDPATVPAGRLRAFTSHPTTSFQLLAPRRCPPVPAPATNTDHSIGILTSVGFRTLEVNDYHKMISHLAPDAAVGIVDIPAHAPGKARREKMVERVESWFGALLRVRNGSGEAGGAGRAPVPILAPVLPVDAEIQRLYFDFLEENEEKIAGLAVYDDQVAMDLPEGLQSMVRVLMRDCGTPQKVLEAVERGTDLFTAVFPNEATDAGIALDFCFPVENSKTGQDEPVYTKDTQQVIVGAVRKQLGWNFWDNERYQTDLKPLAEGCECYACKKHHRAFVAHLLNAKEMTAWVLLQIHNMHVVERFFEGVRGSIEKGTFEQDCEVFKRVYEDEMPNKTGEGPRLRGYQFKTTAGPRKNAKVFGKFTRPGGDRTEKLGEADLPPDMGTVKMEDIGFAEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2U1</accession>
    <name>U4L2U1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to LYR motif-containing protein 5 acc. no. Q91V16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935296">
        <property type="protein sequence ID" value="CCX06563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2U1"/>
    <dbReference type="STRING" id="1076935.U4L2U1"/>
    <dbReference type="eggNOG" id="ENOG502S4S4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRAFMSK"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11983" checksum="AB9BF5B6E55EDC7E" modified="2013-12-11" version="1">MSSLRYDVKRIYKELLYLGRDYPLGYAYFRPRLHKAFMSQKGLQGEEEIKTGIARAEHVKKEIEALYFLKKYRAMRERYGACPSAEVEVERQREIEAMAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Y3</accession>
    <name>U4L2Y3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935493">
        <property type="protein sequence ID" value="CCX09715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2Y3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="222" mass="24974" checksum="07C182C3D582047F" modified="2013-12-11" version="1">MQHTSLCSTLQPCFGHSWESIQILCNQSFKAPRSAIRFPHIPQYSDIERLRVLSVLQLQPVTRLQIRSLNPFDKAQSQAVAFRQIPTVLIRFTFTEISTIIPVFAASISIGDVWTCRKTKRSEEEEGGSQWDESWQIWGLLQLGRSYFAEASNRYTFQQLCDSQLQGNPILLVVFRNSHINCLHKSFSVVLGSSVQDALHGLSSPPPATQTLSTTALGSWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3B6</accession>
    <name>U4L3B6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Succinate/fumarate mitochondrial transporter acc. no. P33303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_02720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3B6"/>
    <dbReference type="STRING" id="1076935.U4L3B6"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX04540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="319" mass="35097" checksum="08C0B47A7A882664" modified="2013-12-11" version="1">MAAVKKQEKKPATMATHLIAGGGAGMCEALACHPLDTIKVRMQLSRRKGSAKRKGFFTVGKEIIQKETPLGLYKGLGAVITGIVPKMAIRFSSFEFYKGLAKKDPETGKIAASAVFLSGLAAGATEAVAVVTPMEVVKIRLQSQHHSMADPLDVPRYRNAAHAAYTVVREEGFRALYSGVSLTALRQSTNQAVNFTAYTYFKQWALQWQPELQELPSYQHMLLGLVSGAMGPLSNAPIDTIKTRLQKSSAKPGESALSRITYIAKDMFKQEGPRAFYQGITPRVMRVAPGQAVTFTVYEYIRGWMEKLSAPDENKEYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3U2</accession>
    <name>U4L3U2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3U2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="302" mass="33258" checksum="126EDE43DD8B20AC" modified="2013-12-11" version="1">MAPGRVLRESRKEEAPLFKHPNPSPPQSPSAKLSTRQPQPVHHHTNNCLSSPPSTLTDTVITMSTTKNISKNVTERKALAAKSTNNHLAATTVFKGKRSFDTIAKDDASNAVPAGAMKRTKAAHADFTHPERKAMMAKAKENHPATKISVAVSRKGKRSFDDTTSKDDGSNDLSTRTMKRTKPTHADFIHPERKAMMAKAKENHPATKISVAVSRKGKRSFDAITSKDNAGSKAPVSETKRTKVVHFDVTPKGTMTYPERLNEAGRTWDILEKAAERKDWGCVKRNNGSWYGMAGVRYKGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L406</accession>
    <name>U4L406_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Nucleoporin nup132 acc. no. Q9UTH0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_10058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935543">
        <property type="protein sequence ID" value="CCX10464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L406"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="90"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="638"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX10464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1302" mass="143773" checksum="5803C3536D9F8D92" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4C0</accession>
    <name>U4L4C0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11279" checksum="853CAA54FA8C5591" modified="2013-12-11" version="1">MSDFHTTVAQAITHFWFWVGIIGIVAFVAYFFVIFATNYIKSFFTKNNTNTNCDNYKYGSDNSRGTATGIEHQVGRHQETLIIARMHGIPYGSAYAETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L539</accession>
    <name>U4L539_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized ATPase YjoB acc. no. O34703</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935586">
        <property type="protein sequence ID" value="CCX11030.1"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0730">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="225"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="43485" checksum="E3C7D55483653EC3" modified="2013-12-11" version="1">MTHGPAPLPTDTSPPIRSRSHSRHTRPHPPPLFRTLLHHSSAPRQSTDLVISSAIRSLHPKLHLTIIPSSSIHLLDFASAGHATCILDPHSPAQIWQETSDITETWFGKYKYVYQDEEFILYVVQWKDSLEMEITRMQYLLGKWNKEGLVKELLKETEAWEGEIGERIWVFDQGRWKKEAGLWGEIQKAKWGDVVLEKGLKERVKGDVERFFGSRERYKELGVPWKRGVIFHGPPGNGKTISIKALMHTISDLDHPVVPNLYVKTFHSMYGDEKSISDIFQKAREVAPCLLVFEDLDSLVSDGTRSYFLNEVDGLASNDGICMIGSTNHLDRLDPGIAKRPSRFDRKYLFPIPGKEERVEYCKFWHFAYLKKHLLQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5C0</accession>
    <name>U4L5C0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04203</name>
        <name evidence="3" type="ORF">PCON_10932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <strain evidence="3">CBS100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935224">
        <property type="protein sequence ID" value="CCX04989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5C0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="444" mass="50186" checksum="F676D60E02FA4C80" modified="2013-12-11" version="1">MDQANQQETENIEDRRGITDADSAEANRVMGYALAPTLWRRRLNRTALSLLVGEAFTSASGYSSYASTASLTYSASPPSSSESSDTPNPLNPDEPTSIARPASTVTRPTTVTFATLPRPDHTRPNHVQTMVELIESLIRSEQGPETTRMDGLPRYRRTLWTRRVMDWEGGMGADRAGTPRMLAIATDTATTAIPDASSASYTSDTSAALAASSTSLALPSSTKQQPSDIDSPTRRFFELWEIFLRMQHMIEDEQILSELRLLGVEGITLEILGSDPDCFERLILPAPAYEVSAEDELLLTEDWGLELEEYKLSWRWMAWAIMRSVVYKDEGVRRDYVVRLVREDVGRVQERVGDVYRKVFREIQDAKERIWEGVMKSGGGRRERKKKQKNKGEDNKNNAGARIRLGRKPGYIWERTRTAWEKRKRVAICGHRNSLLVKLVNTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5J8</accession>
    <name>U4L5J8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5J8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="31" mass="3302" checksum="C4A0FEFF3E30D5EC" modified="2013-12-11" version="1">MNMILHPISMAARCAGDTALLGPDAEKQCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5T8</accession>
    <name>U4L5T8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5T8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="261" mass="27101" checksum="490B5102D0B0C54F" modified="2013-12-11" version="1">MPPGLYTRADGRSEAGLHGSEPNSAGLAAEAFLTMVARDSTTTTTGGSSPSSSGPLYPPPGANIGIIVLFLLLIPFSVYGLYYVHKHLRNCHRAAKKAAMDRDRVRYAYGVEVPGVAMGDIPTMTAAAGVVGTAVGGGMSDAIRIMSCPRHGNAAEAAMAAMDGNKAMLCWSHAAINHTAATQGKEDSMATKEDATITVATTTPKKDASMPTPAAQHAEDADKMVEVSLNDDEDKSSVKNSPGPKNSRARAPRRLSGSGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6F8</accession>
    <name>U4L6F8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to F-box protein [Ajellomyces capsulatus H143] acc. no. EER44331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6F8"/>
    <dbReference type="eggNOG" id="ENOG502S8UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WECPEET"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="398" mass="45986" checksum="7B4538E429C4472B" modified="2013-12-11" version="1">MLLQFPSEIQRLVIRHCEPADLLNVRLVCSQLNTHATELLFSTFTLRRREDQDAKRLRSILESDKLRGVVKYFRFEEDGDEIFGCRAGDVFLRELPSLPSISEFSLRFGPRENTVFKSRQVRPFYREVISSLFSLTRTHTLRSISLENFFPDGIVSPEIATTLSKLQTLKIETMTEYNPPDLVWDTDRDVPGEFQSLRWFIANALPTWLEPATALTSLTLQGNKGTSHIIALDLEGIMFPHLKTLRLQAIAISDDSLIDWIHTHYSTLTSLLLWNCPIISRTIITTPAARQNYSIAFGELPSGPNEMVMGKWERTWAEYFEEMQEGLPRLQELIFGGGEAGWETKRERRAKVWGGMYAALENLKVRELPEMERKINREDEDQLNYLAAVVWKRCREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6J4</accession>
    <name>U4L6J4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Meiosis protein mei2 acc. no. P08965</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935394">
        <property type="protein sequence ID" value="CCX08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6J4"/>
    <dbReference type="STRING" id="1076935.U4L6J4"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="450"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="612" mass="68875" checksum="F07918A1DEC01664" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6X1</accession>
    <name>U4L6X1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWF_A"/>
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    </dbReference>
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        <property type="entry name" value="SLR1338 PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="19342" checksum="8CB20FE5CCD547D9" modified="2013-12-11" version="1">MAKVLISQGCSTEMAMRFSALTLYDVALLIDDSTSMAVKDSENRIDTLRTIVHAIVKIKTIATIRFVSGGMIAANVTPEKVQKMFEAIRFDGLSMIGTALKRRILEPLLYDRQHPRKKPLLIIVLTDGEVECENEATLKTVIKESVTRMTHTGSNHTDKVGFTFVQVGNNFGRV</sequence>
</entry>
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    <accession>U4L7D5</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="16063" checksum="430497ABF79284BB" modified="2013-12-11" version="1">MAHHRWFFEEKASFIRLEVLSESESNDLKLWIGNVYDTLQLPGARRMEHDVGLRPIECEFPTVVVMSSWADSRSKMEWEMHQWMKSSDGGVQKAILLTWVSISQYEVACDLGVYVPEFAENADEDDPEIIGGRKIQQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L821</accession>
    <name>U4L821_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Uncharacterized protein SCO2049 acc. no. P16251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
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        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="13969" checksum="B8BE14A5D32922C7" modified="2013-12-11" version="1">MSTSAFNTGNPYESLFGYSRAVRHGNLIYVSGTTSLSPVAPFDIQFPGNAYYQTTTALEESIRAIAGLGGSIQNIARIKLFVRREEDCDSVGRAMAEVMIGQSFAATMIVGASFVRDEMLVEVEMDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L823</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">PCON_08916</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935457">
        <property type="protein sequence ID" value="CCX09323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L823"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2721" checksum="726E21E0EBA81466" modified="2013-12-11" version="1">MAEALVIFDLRCGITSSHRRRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA00</accession>
    <name>U4LA00_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">PCON_10142</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5546" checksum="88641D83AD4F0C57" modified="2013-12-11" version="1">MVTRGVLRRPVDNPQCSPKAFFLLPRSIFCGETNSLTITFAVRTVCVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA60</accession>
    <name>U4LA60_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_02306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15847.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8352" checksum="528792083D9EFB4C" modified="2013-12-11" version="1">MRAGLVNRNVLLKEWSGGAIFSTDEESGLAEDHRLLVHEKKACSHVFFCFQAAVWDCERRPTGLQLERKVNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAK8</accession>
    <name>U4LAK8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935340">
        <property type="protein sequence ID" value="CCX07194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAK8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="296" mass="34355" checksum="FACB22CE046DD339" modified="2013-12-11" version="1">MDFSPTYPAVPLYLYHKKDLKDRLEQHIKKLSSQPESIRIDKDDLLLYWSLILATGFRDTTKPPGDTITTTRHISYDPSERQDEMPVDISVDLWEKRCNPDFQLNPIIRRFMIYNLYSAEHEACLSAFSDFSPGTPGYEALQKAFLGKMKEVARKYKARYGVYTYITIGPYCSVGYLETSQVLNNFRSTADPVYWIQMKGDYPKFAHILKQKNLVLGTIGYIARRLKEQKFHRLVRYDMKWGEWSINPGIEGFGDKDALKVWKGGRDLNASNRHVKPLDEEFGKRIKMISLEEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAX8</accession>
    <name>U4LAX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SET and MYND domain-containing protein DDB_G0277331 acc. no. Q54ZX8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936202">
        <property type="protein sequence ID" value="CCX15565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAX8"/>
    <dbReference type="STRING" id="1076935.U4LAX8"/>
    <dbReference type="eggNOG" id="ENOG502S6XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITEIVPW"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX15565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="205" mass="23926" checksum="1483D396CB90617E" modified="2013-12-11" version="1">MPSLNPSNLREENTFHTLETLYVLQARPSLRQRHWCLLGEITEIVPWPVRLCIHIRDMDNEELMVSFNDDQRGATFARHPNLKPGSTMAFLYPEFHAFMDGQTGLRIEQPAIHAGAVKILPYSMDTILKVNDQIWKKKGCLECQKCQKKDIELKRCSRCQSAIYCGKDCQTTDWKEHKKVCKVFAEVKWFTDKDWVSASVENFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBK1</accession>
    <name>U4LBK1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936491">
        <property type="protein sequence ID" value="CCX16637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBK1"/>
    <dbReference type="OrthoDB" id="10538190at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="481" mass="57180" checksum="7FF2E3F924E7E3A3" modified="2013-12-11" version="1">MPPVLRKRQAPAPPPPPPPPPKRQRTTRTPPGTRVFRHGRSRPDVSIYIFGDHYHLHGVVLRDKLGWFKTGMSKKVWDATKSHPGQIKYRYMLQCDRFWIGDPDDSLELEQDYDTEHRLEPYGPLDRPERPNPAHFKHQSQIRKVYKSIFESCYYDFTVPEYAMSMRHFEKYLQRFEEMFETAKQYEYTPPIIMGINGFLQHWIGCCTESVRFNGFVEDNCIRFLQLAINFQYRELYKDAWIYTVGQYSKHERQIERFEMKIRLSIWKEVARLERIRKWVQRAFFAIVEQENDDSKPTIDNVCDEEMLRDYEPDLLEIPRCAEHEAYLIMRVHVLSLFSAGELDEDEDYRYEERPDVEIEDEEETRDSETRDSETADSETAGLETVDSETEDSETADSETLASETSDEDPYRHLQDQSPDFVDKGKFLLRNINLLLQNNLKLMKYEEEPWKQGLVCANFERANDEPRYPWEETEEIAIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC23</accession>
    <name>U4LC23_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935656">
        <property type="protein sequence ID" value="CCX11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC23"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="84" mass="9662" checksum="95712F81F23072A2" modified="2013-12-11" version="1">MMKRWNLIDYGTRSRMDCVNGLCQALRWLGLSAGKAAGLWKPMMTMTETKKTFGFVFHRSLILMQLQFSEGQRTCGVHPEFRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCK7</accession>
    <name>U4LCK7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Zinc finger protein RME1 acc. no. P32338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935358">
        <property type="protein sequence ID" value="CCX29804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCK7"/>
    <dbReference type="STRING" id="1076935.U4LCK7"/>
    <dbReference type="eggNOG" id="ENOG502QXVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDCQRHT"/>
    <dbReference type="OrthoDB" id="4738706at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="637" mass="71327" checksum="8B5FCA90623D6F93" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCR1</accession>
    <name>U4LCR1_PYROM</name>
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        <submittedName>
            <fullName evidence="15">Similar to Uncharacterized calcium-binding protein C800.10c acc. no. Q9HGL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_07676</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCR1"/>
    <dbReference type="STRING" id="1076935.U4LCR1"/>
    <dbReference type="eggNOG" id="KOG0998">
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    </dbReference>
    <dbReference type="OMA" id="AMYLVRQ"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="1228"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1202"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX29879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1271" mass="135134" checksum="CF79968F433579C1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCS0</accession>
    <name>U4LCS0_PYROM</name>
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        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Nitrate transporter CrnA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="34"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="504" mass="54094" checksum="5AEDACE136BCCED4" modified="2013-12-11" version="1">MGVSILWKAPKVNPVNKKALSVPIFNPFDKYGRTFFFSTFGFMIAFLSWYAFPPLLTKSIKEDLHLSQAEIGNSNIMALVATLIMRLIVGPLCDRYGPRYVFAGVLLAGSIPTALAGTVTDARGLLIIRFFVGILGATFVPCQVWSTGFYDKSVVGTANALMAGLGNAGGGITYFVMPAIFDSFVKNQGLTPRVSWRVSFIVPFILITATALGMLLFCEDTPTGPWSERHLHAQGASNPSSNEGTIVDTTGNITDHLPVSSSTSGKSSFVDKDDLEAASTRSKQHELTAARIERIAESEVIHAPTFKESLGVMFSLQALLLSAPYACSFGGELAINSILGAYYSKNFPHLGQTKSGQWAAMFGLLNVFFHIIYRATKGSVAAKKFWLLFLGVAMGGMCLCIGLLNPHDHATMIGLIACMAFFMDGANGANFAVVPHVFPSANGILSGVVGAAGNLGGVIFAIIFRYNGNQYGRSIWISGIIMIAVNLSVSWIRPIPKSQIAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCS1</accession>
    <name>U4LCS1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCS1"/>
    <dbReference type="STRING" id="1076935.U4LCS1"/>
    <dbReference type="eggNOG" id="KOG4073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX08291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="25307" checksum="F538C7082CF00497" modified="2013-12-11" version="1">MASPTFTDILTLHYLSKSRFPRYIMASLYRLRGLQSIATRSRSEFTNLTRPTTPRTFLRLNSSQSQACNMSATTTQTKTSTTSASADPDISQISWSSPSTTAARSNVADLLKSGWSLSHTKDGLEREYVFGGFAKAMDFMNQVAQQCRITRHHPEWANVYNTVRIRWTTHNPKGLSEKDIEMARFCDLKAIELGVKSMSKSDWSASAGGNGTVLESMIPAGSACGVCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD51</accession>
    <name>U4LD51_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="HF935699">
        <property type="protein sequence ID" value="CCX12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD51"/>
    <dbReference type="STRING" id="1076935.U4LD51"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWPPFTS"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="50199" checksum="4AC733C4FCC0C4AB" modified="2013-12-11" version="1">MATFVPPPAYTAQQLAQLYPSSLELRQVQVIFRHGERTPVHPRLQNTGLPAHWPYCASSSRFTSAVLAARGSWDTLSYRRRLETFGPSGAAVLASAPGGIVDHICRPGELTDIGRQTTLALGARLRKLYVDELRFLPPAIGEEDTYYLRATPIQRALESLQQVFTGLYPSAFRPEGHIPVIISRSPQDENLFPNEANCRRFSQLARAFAAAAAEKWNGSEEMGYLQEKLGVWMPAGQKVAVDASPRLSGLMDTINATLAHGEGTKLPGEFYDPEVRRIMNMVNVEEWFRGYKESSEYRRLGVGSLLNDIATRSIAAARGETAVKLALMGCHDTTIAGLLASLGAFDEIWPPFTSSIAVETFRVKNQRKSFWGRFTTTDRDEGWFVRVRYNEKPVVLAGCRKEGRHLQGDEAFCTMKAFREAIDKVKTEDWKGDCARNLELKGLPEVELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDK1</accession>
    <name>U4LDK1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDK1"/>
    <dbReference type="STRING" id="1076935.U4LDK1"/>
    <dbReference type="eggNOG" id="ENOG502QQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64155" checksum="5A2A8F679127CBA4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDS6</accession>
    <name>U4LDS6_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_08827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935446">
        <property type="protein sequence ID" value="CCX09234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCX09234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8524" checksum="2B91DDC4D60C2967" modified="2013-12-11" version="1">MAIHRKPTVKFSDSRTLGRLPVRIYGEQSFLSGFATSSDQRTRSYFPQRLIGTFFRFTAVEIRLGRYLHPTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE69</accession>
    <name>U4LE69_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to mRNA 3&amp;apos acc. no. Q4IPA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935776">
        <property type="protein sequence ID" value="CCX13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE69"/>
    <dbReference type="STRING" id="1076935.U4LE69"/>
    <dbReference type="OMA" id="AYWPICV"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="273" mass="30904" checksum="D9326420EFEEE305" modified="2013-12-11" version="1">MQEMLEVDPAMLQNIDDEDYASSGYDTTTASLTASINQYIFENGRRYHTYFGIDKNILPTDETEQDRLDLHHEIFLLLLRGSLFSAPIQNPQRILDVGTGTGIWAIDMADEFPSAEVIGNDLSCTKPGGYVQLCEVGGELYCDDGTLTDDNALKIAFDILNKEAMPKIGRPPATRENMTERLQKAGFMDIVALDFKHPFGPWPKDKRQKRIGAMNMLNMETGIESYFMAAATRILGMEVQKAEKYCKDAFAALKNKNFHTYNYYYVVYGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF79</accession>
    <name>U4LF79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized MFS-type transporter C1683.03c acc. no. Q9P6J7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF79"/>
    <dbReference type="STRING" id="1076935.U4LF79"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LCMSIAP"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="83"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="544" mass="58852" checksum="0855066702D77770" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG38</accession>
    <name>U4LG38_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Conidiation-specific protein 10 acc. no. P10713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG38"/>
    <dbReference type="STRING" id="1076935.U4LG38"/>
    <dbReference type="eggNOG" id="ENOG502STRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HASHEHG"/>
    <dbReference type="OrthoDB" id="2137750at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052590">
        <property type="entry name" value="Stress/Virulence-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569:SF5">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 10 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="148" mass="15599" checksum="7A37DADCA435EDD2" modified="2013-12-11" version="1">MASNNPHNFANLPKEEVRELAAKGGRSQGTHQNTEDTSSSHYNTRSSDNTGSSGSGSDRPGNGNPGNFANRPKEEVRAIASKGGQASHSGGFASMDPERQREIASMGGHASAESGKGGNFANRPREEVQEIGRKGGLSRGHHESDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG95</accession>
    <name>U4LG95_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Putative agmatinase 2 acc. no. O42887</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX15004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG95"/>
    <dbReference type="STRING" id="1076935.U4LG95"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YAQIPTF"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651983" evidence="6">
        <location>
            <begin position="18"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="379" mass="40527" checksum="5F8A7276DDE97B6D" modified="2013-12-11" version="1">MKLSILLSSLLLATVSAHPGGHHEERAVSSQSSHPTYPTNTTLAPNWWNDIVPYGGINTFAHLPHVFCLSQPSETFDIALIGAPFDTATSYRPGARFGPRALRAGSQRQIPAASYNALTGVNPYASWAKITDCGDIPLTSFSSELALAQMTSAFEEIMTHKTPSGGSPLLVTLGGDHSIILGALRAVNKIHGQVAVLHFDAHLDTWDPRFYVGTPFTHGTMLNLAGREGLISNNSNVHAGLRTALVGMGDYRDDTEQGWLRIGSEDIDDLGAKGVVEKIVQRLKGKKVYLSFDIDTLDPAVAPGTGTPEVGGWTMREVKRILRGITTAEDVELVGMDIVEVAPAYDNQGEITALAGAQVVFEVLSGYVKKGELAGKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGJ0</accession>
    <name>U4LGJ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Mitochondrial protein import protein mas5 acc. no. O74752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGJ0"/>
    <dbReference type="STRING" id="1076935.U4LGJ0"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NALCTKC"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="419" mass="46380" checksum="11D4883FF760DD84" modified="2013-12-11" version="1">MSTKGSKTHLYEVLEIQAGASEQEIKKAYRKLAMRYHPDKNAHAPDAADKFKEVGHAYEILSDPEKRRIYDQYGEEGLNGDAGHGGVSAEDLFSQFFGGGGMGGMGGMFGGGMQQQGPKRSRDIVHVHKVSLEDLYKGKISKLALQKSVLCNKCDGRGGKEGAVRKCTGCNGAGMKTMMRQMGPMIQRFQTVCPDCNGEGEIIKDKDRCKQCNGKKTMNERKVLHVPVDKGMQDGQKITFNGEGDQGPDIIPGDVVFVIEQKPHPRFERKGDDLYYKAEVDLLTALAGGTLYIEHLDERWLQVNILPGEVIAPGTVKQIRGQGMPSYRHHDMGNLYIRFEVKFPEDNFNTPEKIAMLEEILPPRTVQEINPDAMYDEVVLEPVDVREQARAQAGGHNHGMDDDDDMHGGGGERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGK9</accession>
    <name>U4LGK9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Golgi apparatus membrane protein tvp18 acc. no. A6RRF7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGK9"/>
    <dbReference type="STRING" id="1076935.U4LGK9"/>
    <dbReference type="eggNOG" id="ENOG502S3AC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYAQWLG"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX30667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="16509" checksum="5D001AEFDF683C3E" modified="2013-12-11" version="1">MGILNNIGEEFKTRNFSIYGQWTGILCILLCIAVGIANIFHVSLILIFSIICLCTGLILIFLEIPFLLRICPTSKVFDDTIRKFHSLWGRAAFYLTGALVQWLSLTVQSTSLIAAAVLLTLAGLFYAAAALKGQEFMGSKTLGGAGVAQMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHD2</accession>
    <name>U4LHD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHD2"/>
    <dbReference type="OrthoDB" id="10619187at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1078" mass="115484" checksum="82551F3B0C97FF0E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHN0</accession>
    <name>U4LHN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized oxidoreductase C2F3.05c acc. no. O14088</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHN0"/>
    <dbReference type="STRING" id="1076935.U4LHN0"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRIHLGV"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="30558" checksum="BC952026FB18C5E7" modified="2013-12-11" version="1">MTFTTASKLTLPNGAAIPHIHLGVYMMTSREAERSVTAALANGYRGIDSAQWYANEAACGAAIGRSGIPRSEIFYTTKLQTNTSYDATRAAIKTSLKKSGMDYIDLYLLHSPYGGPQKRAECWRAVEDAVLEGEVKSAGVSNFGVKHIKELLDRGVRVKPVVNQIEVHPFNQNREIVEYCKEQGIVIEAYAPLVRGMRMRHPVLREVAKKYGVTPAQVLVRWGLQMGFVVLPKSTKEQRIKENADVAGFEIGEEDMKKLAELDEGLVTDWDPTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHY9</accession>
    <name>U4LHY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Chromosome transmission fidelity protein 8 acc. no. P38877</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="791" mass="80021" checksum="2203A629E7CDEBED" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJL4</accession>
    <name>U4LJL4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935799">
        <property type="protein sequence ID" value="CCX32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="15" mass="1460" checksum="12AC6EF4F20E9819" modified="2013-12-11" version="1">MPNGTTGILASLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM74</accession>
    <name>U4LM74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Pentatricopeptide repeat-containing protein At2g17140 acc. no. Q0WPZ6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM74"/>
    <dbReference type="STRING" id="1076935.U4LM74"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMIYKEM"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="541" mass="61844" checksum="008EC23D10BCE34F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNP8</accession>
    <name>U4LNP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to DNA mismatch repair protein msh-2 acc. no. O13396</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01852</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNP8"/>
    <dbReference type="STRING" id="1076935.U4LNP8"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="416"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="915" mass="103029" checksum="78C06D0FC4640352" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP68</accession>
    <name>U4LP68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP68"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="489" mass="55615" checksum="CDD9516EF7C6E844" modified="2013-12-11" version="1">MEVISQFFLWWTFGKGIGFDTGYVKLCHFCKVIVEMAAKVKVQFFSPKMGHNQHWCSSRTRTLSFMLHLHDKDHHGPGKNNQLHCRSLSGNGRQEQGSRAYILGVRSEGLEWWQDNFAHPNNTIGTFDDFRIDIVYNWFNNEWMYPFKDYALPRDVKTAKFPLIHRTERHVNITTKCDMYPIVSGQDGGPRNVKVLVNGTEQEHPWADKFKAANKTVYMNPNINPSTEERSGYDWDSTKYNCGPRCGYTFIYRFVHNTSIPTGDFINCTTKVSTVHNAKSGVAEHQVPDKVASRIASSIDSSSFMKYNQQHKMLYSFNVMDSSWNETNPPYSSARRGSFLLSRFAIGSLAMLDSTGPRLMAEGDAPYLGIKMDVNWQKVAGGVAGLLGVQLLAGIVTLWLSYPVVCKDSSYWSTARLLRLVVQRMEETGSMASGDQIAGLFKNRNMRYGVRTDKEGNNYLEILLDTPDFIPGSDTRYKKGAHFSKGYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPQ5</accession>
    <name>U4LPQ5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_10573</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPQ5"/>
    <dbReference type="STRING" id="1076935.U4LPQ5"/>
    <dbReference type="eggNOG" id="ENOG502S890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SQMWANY"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX31290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10845" checksum="7AF22365D92CEE01" modified="2013-12-11" version="1">MESPHEHQQNQLLSRIINNVEKLNESIKVLNKMLEETSDKNANPDIVAQMWKNYHSNVQFNLEVCRIRNNGVRPSNSRDQGKAGKAGSGMEARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ08</accession>
    <name>U4LQ08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ08"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="142" mass="16239" checksum="80681C38788EF01A" modified="2013-12-11" version="1">MGKESPATSKGKKTPATPIGDESHAKRPHRGCGFIRYRWNRLQLALQRACSKPLAWWPLKGPNCQYAGPRSISKHHCCDDCHVDGRVYHSIGPRPYAHPRELREDKKAASWVFHDCRAAIQWNRDYSGEHKIEGSKGYTKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ73</accession>
    <name>U4LQ73_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ73"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18812" checksum="9A8633DB10804835" modified="2013-12-11" version="1">MPLIWFEIHIKCNSLEIRIPTNPDIGGNGVFISMLLSSIFSIALTMAAFFLRPFSIGIEKRWPNREKTRKKCRQKWYPTIQATLSSISDQQFVSGLAVLSAANGNFNNMTMYHRTLAWYFAFLCQGCFTANMEFEDAPLDDNEPSKSEEPIPENADDDKDQKNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ84</accession>
    <name>U4LQ84_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_10844</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ84"/>
    <dbReference type="STRING" id="1076935.U4LQ84"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="138"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX31495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="40376" checksum="3CD6F49EF5600F53" modified="2013-12-11" version="1">MTLVRCDVANRLYWTTALSKTMATISCQNCSKELSVDAFPLSPPSECSHRCCWRCLNDYVLDADEDDFETDGIDCFKESCGNTFTDLDYKNAISDYKWAKESPKACSECGRLLARYYFPRGSRSDDALDSTCIMCLRTTVTCILCTNECLRSDCPTVTSQCKHPKHSCIDCVRRWLNISQETKYLEFRCPGDQCKADLSHGDLRRVADSELFAKYERETLKNVLRNLPGFFFCLGAGCEYGEELDNGVKEGIFVCKACNSRTCLSCEAIHDNVSCDQFKRGLTSLDMVHEEEMALSLQWTNQNAKRCPGAECGRLIWRHAGCNYMMCSMCRTRFCWNCLKPYATSPLCQCGKYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQB3</accession>
    <name>U4LQB3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936516">
        <property type="protein sequence ID" value="CCX34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQB3"/>
    <dbReference type="STRING" id="1076935.U4LQB3"/>
    <dbReference type="eggNOG" id="ENOG502S8B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVFAAPW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="51023" checksum="C4EB57D8F4D28429" modified="2013-12-11" version="1">MDLTFITMHDISDDALILYASDSIDDVLGYKPTDVVGQSSFLLFQPESRNEALTHHRKLFTKDTAAELKYCNMKRRDGTIVVCECVFTVVYSVIVSCTSLYKYTEKSQQRALHAPAISEALSRNEKDIRFGMLKHLSSKFTTTNAPHEPRCALILNRFTRTLTVMYATIGLQEILGVPAEEVNGKSFYELIDEACLVDAAYALEKAKENDSIAYLRFRVRDPRNNPRLPQHPMFDEQREVHDEEDDNDANEDATSSQGSSRDEDSEEDDQDDDATASTPRRGNPRRARRNSTPDSIVSGAEPSIEVEAVISCTSDGLVVILRKAHGIPPIKEGVALAPWAYENKMPWNDQRLYAPTPNTQEDLFMKAIREVAVFAWSLRSINEDIMCHVVPGTLKPSASEVVGNYTRKGTTFYRREREWEVAVEQRNKRTREGEEEEEGRESESRPAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQG2</accession>
    <name>U4LQG2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ubiquitin-40S ribosomal protein S27a acc. no. P14799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_05617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQG2"/>
    <dbReference type="STRING" id="1076935.U4LQG2"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WARLMLQ"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS31" evidence="4">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX29546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9230" checksum="9D3074DCCC6A35EE" modified="2013-12-11" version="1">MWARLMLQPRSAARVTQGWKSTKPTKLAVLKYYKVDGDGKIERLRRECPQEGCGAGVFMAAMQDRQYCGRCHLTYVFEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQJ4</accession>
    <name>U4LQJ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQJ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3625" checksum="4CE962B470F6001C" modified="2013-12-11" version="1">MDSVALLLCTIPCMRMLLTLHPNPVFDLPVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQQ2</accession>
    <name>U4LQQ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat domain-containing protein 50 acc. no. Q9ULJ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQQ2"/>
    <dbReference type="STRING" id="1076935.U4LQQ2"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DEYSCCE"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="131" mass="14519" checksum="0E1492140372B444" modified="2013-12-11" version="1">MIASIKGHEQVIEFLLECGADLNRQCRHGRTALSYLAEYGRDNIILMLLKKAPNIDLPDLGAQIPLLRAALKEHISTVCLLLENDADVHLRDRDGLTPLCHASQNQHTSLALLLLEKSASRKSAPIPCYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRA8</accession>
    <name>U4LRA8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRA8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9077" checksum="3D61FE74C2CEDBC0" modified="2013-12-11" version="1">MASSEALGNASKAEAAISTIEEVATATGNEAADYREAVNREANGVGVQKMNDAIETFRQMQQKLEELYAPLLAEQQKLDSCVSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRN1</accession>
    <name>U4LRN1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRN1"/>
    <dbReference type="STRING" id="1076935.U4LRN1"/>
    <dbReference type="eggNOG" id="KOG2255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSYMNES"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="194" mass="21297" checksum="2CF2543D2CDCE411" modified="2013-12-11" version="1">MTVAPVSRRLLVCSLGNPGSQYALTRHSAGHILLRLASSRMGSPPLQKDSNYKGPLTRTPCGTYTFFASPSYMNVSGGALKHAWKTFLKELQGAERESALMVVLHDDMEKPPGQCRFRCTGSAQGHNGLKSVIESFATKDILRIGIGIGRPKEREPVMVADYVLRQPIPREMEELETTAVGKVVSHLKHIQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSM9</accession>
    <name>U4LSM9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ER-derived vesicles protein ERV14 acc. no. P53173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSM9"/>
    <dbReference type="STRING" id="1076935.U4LSM9"/>
    <dbReference type="eggNOG" id="KOG2729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15924" checksum="E6213EF9D2465C6B" modified="2013-12-11" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNSYIKPEAAVHAFLTALFLVNGYWVALILNLPLLAFNVKKILNNAHLLDATEIFRTLNGHKKESFIKLGFHLVMFFFYLYSMIVALIHDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSW3</accession>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5370011at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="334" mass="37233" checksum="5F424C485BF53770" modified="2013-12-11" version="1">MAGEAEKSSSIRRRFTTSIKRIMSNKSGKSQPSGGSPSVIDAAPAAAGSAAASPAAAGTHKPYRPPKNPTAPPPNMTAAERAQALFKKHGLEVKSSDLPLSTAPQAERVQKDIRMRVHRTCHKCETPYGPDKTCTQCGHKRCKRCPRQPLKKGKDKGKEKVTAKGITAPGYKKRRGDFMYGITIPGRRGGQDLVHKEVRQRVHRKCHHCDEDFAGEKVCKKCSHHRCKKCPRLPTKSKNHGPDYYQKADPTDSENEHFPPPPRRTYKKPRRRIHWTCSKCETTFIEKTRICSGCGSNRDDTGVRDPPKKPKFKGASEGDVQRLSDRLRTTQLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU10</accession>
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        </submittedName>
    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
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        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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            <begin position="250"/>
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        </location>
    </feature>
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        <location>
            <begin position="592"/>
            <end position="637"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="655"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="759" mass="83156" checksum="8ADF5FD1720877A7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUD5</accession>
    <name>U4LUD5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33605.1"/>
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    <dbReference type="Proteomes" id="UP000018144">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="27483" checksum="C52F24657DA5AF2B" modified="2013-12-11" version="1">MGGPTLDQLTSSGGLDWIHYSPVNPVLPSNHPGVINQQDSIRPCVAPLKSSPAPVSGSGLGALARTSPLAPPQQQQDQEEQPMALIVTFATQSGVEQFKSYTDKHGIWVLVQHPQRGLADNKMVIEGVEYPIFKESHRGILYAKKNILGAKVRVYKGLEGMFLQWYKMEDGSGLKESRDAEATRVIEVQGDSGTIERKITAMKCSIELIKITSGGGCPYLFICVCTVSGMQLGLWIDPKEDNGNKVFHRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUG2</accession>
    <name>U4LUG2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Meiotically up-regulated gene 14 protein acc. no. Q9P5M9</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11098</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LUG2"/>
    <dbReference type="STRING" id="1076935.U4LUG2"/>
    <dbReference type="eggNOG" id="KOG3699">
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    </dbReference>
    <dbReference type="OMA" id="AFYIHAR"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="74"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="33884" checksum="01AE87B0A16087A7" modified="2013-12-11" version="1">MAPSHIHTITSTPVTINVPDEPVKPTTLEESEVPVDVKPAAPKKSALELISHGGPILEIPQFVSFDARRQHILQHMSGAFRVFARRGFTEGMSGHISVRDPEFPDRFWTNPLGRHFGLLKPSDMVLLDEHGTVVGGNRSRPANAAGFFIHAAIHKARPDVNAAAHMHSTYGRAWSVFGKKLEMLTQDACIFHGDAQGLYDAFQGVVFTVEEGKRLADALGPRGKGLILRNHGLLTVGSTVDEAAFLFCSMETACKIQLQADAAGREKHVVPDDEAQKVFEETSQADSLYWEFQPDLEYEEAMKEGGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUG5</accession>
    <name>U4LUG5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUG5"/>
    <dbReference type="STRING" id="1076935.U4LUG5"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="417" mass="46850" checksum="61F3711ED86A0D76" modified="2013-12-11" version="1">MSVNQSFATSPDEWPAENHDHPETRGYALLSMVAFFFTAIIVIAFVGSLHHSWGHHIWDIPTIQRSNALFLTWITEMLTTWSLTLTKLSICIFYLRFLSDTRRNRIFLYLLMTTILAWGVGFTVTIVMRCTPIKAVWTLRIPGASCSYAASGAIVHVAGDIVTDLALYLLPLRRISNLRTTTRQKALISFVFILGAIVCLASILRVPASIDSMTRVDSTWHSWYYLIWTILECGLIIVVACLPALAPLLIRHIPNFGPQGIETETGPDGHDDHDIYSGDSEDHAYNKPDKRRPSEVSVKSIKGQTKSTTKGHKATHSMSTRHPNSKFKSTISKAFLTKDTQAAHSYPLAEIDIDVWGRQGGWEGRRGLSSPDSRDGILRDENGVRVATEIEQIFEGRSPIRNKRETQWIPYGPDKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUW0</accession>
    <name>U4LUW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Uncharacterized protein RSN1 acc. no. Q03516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_02535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUW0"/>
    <dbReference type="STRING" id="1076935.U4LUW0"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FVQFNHQ"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="784"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="829"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="94"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="269"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="625"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="736"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1245" mass="137975" checksum="41EC093CBC2A569A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUW1</accession>
    <name>U4LUW1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to DNA replication checkpoint protein tel2 acc. no. Q9P3W5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUW1"/>
    <dbReference type="STRING" id="1076935.U4LUW1"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGIMVKL"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="625"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="963" mass="104302" checksum="743CE7B1B28898E8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV08</accession>
    <name>U4LV08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV08"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="1910" checksum="1387FB1789DB8DBE" modified="2013-12-11" version="1">MFQLSTRQCASDYAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV98</accession>
    <name>U4LV98_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_03604</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV98"/>
    <dbReference type="STRING" id="1076935.U4LV98"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YRMYVKG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="974"/>
            <end position="996"/>
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            <begin position="1045"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1167"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1180" mass="127900" checksum="CBA805856B5B3D10" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVE3</accession>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5451" checksum="23CCC7AA4142CDE1" modified="2013-12-11" version="1">MLADEPQKYQISGCVVISNTGYMYDISLHSWISDAVFLVAYVPDEHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX50</accession>
    <name>U4LX50_PYROM</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="14" type="ORF">PCON_03213</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
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    <dbReference type="STRING" id="1076935.U4LX50"/>
    <dbReference type="eggNOG" id="KOG0032">
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    <dbReference type="OrthoDB" id="74764at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="157"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX34243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="600" mass="67965" checksum="B10F1F08EA438508" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX54</accession>
    <name>U4LX54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX54"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="18334" checksum="C708828E5C70ED5E" modified="2013-12-11" version="1">MDSTNPTAADSLLQTVNIISDSKPKEPKQLGDTKSFRSCKKLSLPPKESEPLPPKAIITHCMLCNLAFENFPGHNDWCRVQMLECFCAPVHNKCWKQHCYEFTEFNQRPVPDVVCVQCGAVVKSCKVLNGRWYGEDGDLVHGYKEERFTLRRARALGNFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXG0</accession>
    <name>U4LXG0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXG0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="12296" checksum="C21DC83910C8672F" modified="2013-12-11" version="1">MYNDESNLDCYRETSEGPERLLVFDGKGEKIRWEVKRTRTVEDLDENGNLKLNENGSVKYKDEEYYVYPEGVVSKSWGGGVYGWSLEREWTDTYRAVKKGKKNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXL9</accession>
    <name>U4LXL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXL9"/>
    <dbReference type="OMA" id="TPGHENG"/>
    <dbReference type="OrthoDB" id="5404498at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="744" mass="79114" checksum="CC6E9D83E0631615" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYE8</accession>
    <name>U4LYE8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to AP-1-like transcription factor acc. no. Q01663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYE8"/>
    <dbReference type="eggNOG" id="ENOG502QZI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="216" mass="24537" checksum="728A7A7D99D5EEB8" modified="2013-12-11" version="1">MSGRMEMPRVPPEVEAGFPEHIQNHIYDIRGRSASYSSPSNPTLSDSSQPSSRSPFFSFLKINKPKEDGEKPKRRGPKPDSKPPLTRKQELNRQAQRTHRQRKEFYVKSLEKDVARLRETFTIITKEKTALLRENMRLKEILEQHGIVYDPDMDYGYGQNQYPRLTGTTITDTPITATGPLPPDTTYDHIGVDFVLAQTGETLHGAPNSSLYPPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTU6</accession>
    <name>U4KTU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Zinc transporter ZIP9 acc. no. Q5BL29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTU6"/>
    <dbReference type="STRING" id="1076935.U4KTU6"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="345" mass="37076" checksum="2DDC9B94C86ED21F" modified="2013-12-11" version="1">MPDGLFTLLIYCVLMAAASFGAGMLPLAVSLSQSQLRFISTIGMGVLVGTSMIVIIPEGIETIYSAPKPMAVQHAERALRIRDLGIKWHAAPAVLQTRDVHVPNYNFRREAQDDTVVAAEVLGQQQEKQEQEQEHTHVHTHTHEGESQERTEQPGEPEHDHEHEHDHEHEESSPHAWVGLSLIAGFILMYLIDVLPSHAHNHDAQPYHIAIDNLRGSMSSPGPQATPHASRPSAMTLGLVIHAAADGIALGASSGSQNLGLGLIIFIAIMLHKAPAAFGLTAVLLRGGLMKRQVRTHLLVFSLAAPAGALVTWLMVGLLGGGMGSGDGVTWWTGVLLLFSGGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTX0</accession>
    <name>U4KTX0_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935207">
        <property type="protein sequence ID" value="CCX04528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTX0"/>
    <dbReference type="OrthoDB" id="2986625at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="52136" checksum="A92CB0661E56AB54" modified="2013-12-11" version="1">MTRGLLLQLPAELLSEIVSHLDKVPRKARCFEDVQETVLDAIQYRRDLRNLLLTCSTLYRITAPIYYGKVFIDFDQFEHNGPRSMSRKMRLWSQDPVASLIKKHARELSVDMQDHILQRFHLLYDFVSSLPKLQALFVRGQFQGVHAHLEWEQILSCQTIRRLHITSFDTEVVYHRTTVDFMNRLSGCLKNHPVLDELRFTWEPVPDIYTHILHYNISGHGSPKLGGNDIPFRTRSLIIEGWSLGSDYLKVSPTDLKRLKIVAALTSTTDDGFWQALGTNNTHLTALDCNKPSKAMIKYLASYRGLEELRLSGVRSTDSNSFNPIDALSIHQGSLKILDMAKCEDIGDQWTVGIDSGRHLLSAILDCRYLETMSIPTWASPKELIELVDTCVKLPKLQKLALTSNVDRGGISPQAFQRVIRNTGLRELTLSGIEMDYSLGCADGWPVVYEISVIRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUB1</accession>
    <name>U4KUB1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935197">
        <property type="protein sequence ID" value="CCX04286.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUB1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04286.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="364" mass="42021" checksum="968F15E3ECE4B281" modified="2014-03-19" version="2">MSGYANALSGVPFFETLQTLFTKSHLFISGDCVSEMLYNMIWTGFWDLKYKNRCIKEVLRHGPSLDKLDKHGKTLLHSPFTWREAEFYTLESCCGIYNPCCGQYIEHLEEALYALIPAGADLRAVDMHGETITETANRRQLCGVWEKALIDCGHNAKHLIAADLRVGLIYRSLDGSIIEGTRLADHNPEYICEGCKVEEWRWRSGKCLEVYGNDSWLWGNAWPQWVRRPCERYYNWILDKEPEHRDDIEEDSDEESREEYSEEEYSEEEYSEEEYSEEEETQMKGVEYDIMIGSKERYCVAEGDSNMRSASPVLSDVCMGEYKYFSPAAFDPQSPPRTIDNGHSRGFVEDMSESEDESSDVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUJ5</accession>
    <name>U4KUJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUJ5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14203" checksum="98D39C843DD8EC6E" modified="2013-12-11" version="1">MPDALRPFMKALEHITQFTSVLIYHQDGKLPTLATVLQILTTTYPAPNINFRTVQEHITLLPTINDAMNETNFDEHDRNAVIAILATLQYIFGAYGDTFPWVMYLLRLFGDQLAKDYGTTPMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUZ4</accession>
    <name>U4KUZ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935243">
        <property type="protein sequence ID" value="CCX05273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUZ4"/>
    <dbReference type="OrthoDB" id="10557582at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="439" mass="50357" checksum="132155E6A4B33166" modified="2013-12-11" version="1">MLPCNFFPSHLVASLATGKTCIDATSSEIHSRGIDITNYFPKYHRYEFHHRGRCKTNPFCKWQDPSPAPAIAIRDCTKSPSEMTKEEHHQLLDAAVDLFDDIRALYESVSSTNEKEESSRIMIDEIKTWPDANILPKQWVGQPITLDDIPVALQSLVDELVSFDTSDRTEEEKVKDAVDILPTFLLVIFFTNEEKMAEVAKSLGPLRHDFSNLEVYGKYRAECKKDEKEGGDTMEFTSAIEPTKEPLNDNADTYPKEIMVELKTEEDWDKEDEAIVKFVEDNANYKYDNVEAPTYNAPTTYKTQWVEVKNKEEEERIHKEYQDKLNEHKKIRVSMLASSPRIQEAGERYGRTHNSEMSTFDYNETEGGDALESTSDDALFASVLKVESHQDPYIFQGEEVTPDNIPGQLKLMVDDIVSEDKSNRTEEEKVQHAIDYLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVH2</accession>
    <name>U4KVH2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Pre-mRNA-splicing factor brr2 acc. no. Q9UT24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935219">
        <property type="protein sequence ID" value="CCX04901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KVH2"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="531"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="742"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1385"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2199" mass="248122" checksum="1087F220780B65A0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVT5</accession>
    <name>U4KVT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative HTH-type transcriptional regulator ywnA acc. no. P71036</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935271">
        <property type="protein sequence ID" value="CCX05743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVT5"/>
    <dbReference type="eggNOG" id="ENOG502SZI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221:SF15">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR YWGB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="WINGED HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, RRF2 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651124" evidence="1">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="142" mass="15405" checksum="4D465D3BAC48054F" modified="2013-12-11" version="1">MVNSNQFSIAIHILCFLAFNASGRTTSELLGVSVNTNPAAIRRNMRKLTQAGLIQSSLGVHANITLAKPAEQITLLDVYRAVTDGQQEKFFAVHRSTCPTCPVGSKIPRMLDQVYGKVQVAMENELAAVTIASLAGQFDQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW32</accession>
    <name>U4KW32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized aminotransferase C1771.03c acc. no. O94562</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_05470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935275">
        <property type="protein sequence ID" value="CCX05883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW32"/>
    <dbReference type="STRING" id="1076935.U4KW32"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWAVEHS"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="459" mass="48668" checksum="55AABF457409CF81" modified="2013-12-11" version="1">MAPAAVPQQSNILHRVLADKPHHAVSSSGINIHLANLHNVIDAAGGASVAVLGHTQPSVIEALTKQMTDISYVYSGAGYSSNSAEELASLILSEKPGGLCKAIFVCSGSEAMECALKLARQYHCERGDMKRIHYISRKNSYHGNTLGALGVSGHPGRRAIYEDMLSKNVSFVEPCYVYRGKKEGEDDKAYLERLTAGIEEEFQRVGADKVAAFVAETVSGASLGCATAVSGYFKAVREVCNKYGALMILDEVMCGMGKTGTLHAWQQEGITGPDIQTVAKALGGGFVPIGGVLMNQKVVDALASGTGILQHGHTYQAHPGACAAAAEVQKIIKRDNLMQNVMEQGKLLEKLLKETVLPLKIVGDVRGRGLYWGVELVSDKETKRPFDRGMAVSSKVGASAMALGLGVLPTPGAGSEAPVDILIVSPPYVVTEQDVRSIVGILKAAIEDITRTLEDSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW44</accession>
    <name>U4KW44_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Alkali-sensitive linkage protein 1 acc. no. Q09788</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935262">
        <property type="protein sequence ID" value="CCX05627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW44"/>
    <dbReference type="STRING" id="1076935.U4KW44"/>
    <dbReference type="eggNOG" id="ENOG502S2W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYDNFAG"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650788" evidence="1">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="36"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="289" mass="32149" checksum="8E29123F2B41A4BB" modified="2013-12-11" version="1">MPLFLTPLLSFILLSLLHIAAASKRGLIFIPALSNSGSTLGNNPGRLSWYYNYHSRPLPNAPTSNLEYVPMLWGAPHPGQDFYADVSSLPQLPRYILGFNEPDMSRAVGGSDISPGYAAALWRQHIQPWAARGVKLGAPAVASTPNGRQWLRDFLGACSGCTIDFLPLHWYGNYKGFREYIWSVQQEYPGMELWLTEVGFPWESEGETRSFFEDVIQFLDSSPAVGKYAWFGSFKVGEGNIGPNSAMLDSNGRLTALGQRYVGSKRRWINRRRDLRRGLRSVGSAGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWE0</accession>
    <name>U4KWE0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWE0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="213" mass="25592" checksum="8A62465401D3A339" modified="2013-12-11" version="1">MPSFFNLRCRLSGDYSSPRRPNTPRHTPGYNYLTPHHSHRNSVQSTHSRHKCHHESHPRHSRQSYQDDLLIHYTCGHSSPGVVSQRVDSVCQACFWNWYEGKQSIFSFLGFGRSKSTKSTKLGRMRYDEDSEEEDRRDRRSRRKMEEDQGDFFGILGGNRPVRREDKYERKRKQKEMEGRFVRGFEEERERREYRDYGHDCGYRRRDVGAVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXB2</accession>
    <name>U4KXB2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935289">
        <property type="protein sequence ID" value="CCX06436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXB2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8372" checksum="29BB13B5B289234F" modified="2013-12-11" version="1">MITPSTKTLKSGKLVHVRRNAIKRKGSQQPIYVPAVYAPDKMDIDPKDEEMSDAEKAPFSRIKSGWMRSIKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY70</accession>
    <name>U4KY70_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935335">
        <property type="protein sequence ID" value="CCX07137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY70"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7313" checksum="2AA01F46C58CC88F" modified="2013-12-11" version="1">MSHRFITTTPNLKYYLRIANKVPCSSFLCSVSTPGWNKIRNSFEDTFMCINCTPISNLKYAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ63</accession>
    <name>U4KZ63_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ63"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10560" checksum="0E9B498382998DAD" modified="2013-12-11" version="1">MGAVRNVRPCYTNTGSDINKAAGILTECVPAVRIIIERVVTEKRAHIEEQAEELWIWDCTTRVYCHEECLASEIAGIEEMQSTEGRTAYLRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ81</accession>
    <name>U4KZ81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935369">
        <property type="protein sequence ID" value="CCX07740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ81"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="7150" checksum="E71C8DEB4A71F3B6" modified="2013-12-11" version="1">MFTECAHYAGPHGQYFRREACTVLLPNQRFLSCRDPLMELRLYSIANTTSPAQGFNQAELRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZB9</accession>
    <name>U4KZB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Carbonyl reductase family member 4 acc. no. Q6NUE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZB9"/>
    <dbReference type="STRING" id="1076935.U4KZB9"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCMITGG"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="233" mass="24348" checksum="4F996E3CF1F6FA24" modified="2013-12-11" version="1">MALNKILITGGSRGIGLAIAHRLAAQGASCILMARNGNVLEDAVTKLPARHGQKHGVIAGDVSSPDVWEMVRREYADIDTLINSAGISQKSLLISTPVEQVINTLNTNLLGTTLACRAVAKSMMRRKSGSIINISSVLAHKGVPGSSIYAASKAGILGLTRSLAVELGQRNIRVNAICPGYIETEMTAGLQPEMGPAGRMGTTEEVAEVVEMVLKNGYLNGAVIDVDGGLGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZG0</accession>
    <name>U4KZG0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Guanine deaminase acc. no. Q9R111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZG0"/>
    <dbReference type="STRING" id="1076935.U4KZG0"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INDHYFF"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="79"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="462" mass="51034" checksum="9FF89FF2BCF8D41B" modified="2013-12-11" version="1">MSKIHYPASEANGTESATTGKLHIIGTFIDAPSCDILRVRENTMIIVDLESGLIESIEEAPKVEGNRPAEVNNGMMAYVPGFVDCHIHAAQFLQLGTKTDVPLMEWLNKYTFPAESAFSDDAHASKVYDSVVRSTLRTGTTTACYFGSNYTSSTLLLGQLCHHYGQRALVGKVCSDQLVPDNYIETKNQSVEDTKRFIESFEAIPGDLVKPIITPRFVPTCSKDLLDKLGELAKIHDCHVQTHAAEIASLHPDLKRDIPILNSSNLLRGTGKTILAHCTHLLDPELQFISDKASVIACPLSNLLFARAVVPVKRYMKHGVQVALGTDVAGGWSSSMLDSIRMATVASGVHGMQPPVDRTRNPEDHVLQESKEEEERFGFVMAFHLGTAAGGKALGLDTGVFERGMKWDALKVELVGDEERERLPMMKEMGWRDMVERWICQGGGERGIREVWVDGNLVMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0C7</accession>
    <name>U4L0C7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to UPF0614 protein C14orf102 homolog acc. no. Q80XC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX08014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0C7"/>
    <dbReference type="STRING" id="1076935.U4L0C7"/>
    <dbReference type="eggNOG" id="KOG1972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRDKELH"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX08014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1202" mass="138713" checksum="CDA0F6EC9AA079F2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0E8</accession>
    <name>U4L0E8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to DnaJ protein homolog xdj1 acc. no. O94657</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935419">
        <property type="protein sequence ID" value="CCX08558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4L0E8"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="173"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="173"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="48677" checksum="2CDBB5AF44549206" modified="2013-12-11" version="1">MLISFVSRPTASHVKETSDVNGSSESIDLYEVLGIARGASKTEIKKAYHKAALSSHPDKVPQDQREEAEVTFKAVSQAYEILYDEDTRARYDQFGMAAFEKGGSSGMDAGVDLDDILAQMFGGMGGMGGMGGMPGMGGMGGMPGMGGRGPQRRQRGRDVVQQYEVSLEDLYKGKTVKLSSTRNKLCGACEGVGGKAGTKPKKCATCDGRGWNQTLRQVGPGLVTQENVNCGNCKATGKVFREKDRCKKCKGDCVTEEKKVLEVYIPRGSKEGDKIVLEGEADEQPGYDTGDIVFVLEEKEHEVFSRAGADLMAPLKVDLVETLTGFSRVVLKHLDGRGIQLTHPVGEILKPGQTIKIPGEGMPHKKGEGKGDLYLAVQIEFPENGWSPDVEAIRKVLPVAKPEVITGEPIDELDYIREASIEDFGGEDASWEDEDDEDDDEGDGPQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0L2</accession>
    <name>U4L0L2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized protein C691.05c acc. no. O13621</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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                <person name="Kumar A."/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
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    <accession>U4L161</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1I1</accession>
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        <submittedName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="182" mass="20869" checksum="25BD3E1245EF07FF" modified="2013-12-11" version="1">MADNPIRFNFIDFLKLGFLHRLFRPKADAIPPDDDDEQPQAPITTNEDGLIIEGDESGRDADDERTDSTYDSDVSGGVLDDYDSDESYGIAGNNYIIACCACSPMVHCLRCLFYAFWNMLVAMWACVTRRCCAFWNMFVRAWVWFKQKCLEFHAGYKRVVDAVADFYMDWANLDRGQDDHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L346</accession>
    <name>U4L346_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L346"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="4152" checksum="FDBCC7A6E84D1B4E" modified="2013-12-11" version="1">MQPNIRQYLSLHLAFLALIQVLHLTETDNIKYTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L386</accession>
    <name>U4L386_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Aprataxin-like protein acc. no. O74859</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX09988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L386"/>
    <dbReference type="STRING" id="1076935.U4L386"/>
    <dbReference type="eggNOG" id="KOG0562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHDMFPK"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX09988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="28381" checksum="510542DB5172B3E4" modified="2013-12-11" version="1">MSAPQPPTFTASQPAKKPRPNPRFKAPRDGLGPYISHPTSFPPTAVITHNENFVYIRDMYPKSIIHTLLLPRDQSKTKLHPFDAFSNLEFLRKTMYEAKKLKALVAEELKRLFGEQEGRDWEQEVKVGVHAAPSMNHLHVHVLSRDCVSERLKTVKHYNSFNTPFFIELDEFPLAEDDERRNPTRGALLKQELQCWRCGKSFKNQIKQLKEHLDEEFEEWKKTPKVSAAKEGKAKSVTTDEGGTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5G5</accession>
    <name>U4L5G5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935693">
        <property type="protein sequence ID" value="CCX12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5G5"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14321" checksum="B1FCD6B7ED4DA74E" modified="2013-12-11" version="1">MGCTPSTIRLTTSSNPQPSTSRPSSQDSTITTPPFREEMVISWPTKCYRRPGVPFTAGGLGFENQLSEDFWNMEERKEGRFLIGQVDVVGADFGQEEEGEGEGEDGDKEREAERDREREAQTSSAGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L678</accession>
    <name>U4L678_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ubiquitin carboxyl-terminal hydrolase 3 acc. no. Q9Y6I4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L678"/>
    <dbReference type="STRING" id="1076935.U4L678"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCYNNAV"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
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    </dbReference>
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            <begin position="77"/>
            <end position="444"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="69"/>
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    </feature>
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            <begin position="462"/>
            <end position="601"/>
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    </feature>
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            <begin position="1"/>
            <end position="28"/>
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    </feature>
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        <location>
            <begin position="496"/>
            <end position="520"/>
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    </feature>
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            <begin position="528"/>
            <end position="537"/>
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    </feature>
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            <begin position="553"/>
            <end position="578"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="601" mass="66291" checksum="4F8DF2A5617939C2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6E6</accession>
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    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935704">
        <property type="protein sequence ID" value="CCX12479.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7867" checksum="F8ABDC57E383FF96" modified="2013-12-11" version="1">MTSLESIFAQNALSVLPTPLIQEWTDQLRNLDWKLREEIEQLKEEKTQLDAKVKALIEENEKNLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6G2</accession>
    <name>U4L6G2_PYROM</name>
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        <submittedName>
            <fullName evidence="10">Similar to Probable lipase C16A3.12c acc. no. P78898</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">PCON_05202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="250"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="732"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="940"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX05615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1190" mass="131603" checksum="C8B9C318EB96F799" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L716</accession>
    <name>U4L716_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L716"/>
    <dbReference type="STRING" id="1076935.U4L716"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="14"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX13204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="37302" checksum="24CC2374CE5E7533" modified="2013-12-11" version="1">MSIPSGENPSFVLNSIKSVAFEDRPIPSLKSPTDVLIRIGITGICGSDVHYWQHGSIGPFILKAPMVLGHESAGTIVQCGSAVSSLKVGDRVALEPGIPCRGCKFCKAGTYNLCTDMKFAATPPYDGSLAKFYVLPEDFCVKLPDNVSLEEGALVEPLSVGVHVCKLANVTAGDKVAVFGAGPVGLLAAATARAFGAAEVVVVDISEQRLKFAGEYAATGTYDARKGDARANADGIKEQFGWTFGADKVIEASGAEPSIQTAVFVLRAGGTMVQAGMGRDVVAFPIVEAAAKELVVKGSFRYAAGDYELAVKLVAEGKVDVMKLVTGRYDFKDAEKAFEETKSGKGIKVLIRGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L719</accession>
    <name>U4L719_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L719"/>
    <dbReference type="OrthoDB" id="10403465at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="20098" checksum="E41168DF3573103B" modified="2013-12-11" version="1">MHEQRLPGAAAGADGPVAGPGPGLAIPATGGAAGQVAGPGAGMPVAAAATGPGPRMLMGQIYDAIQNEYTPVVAPENTGPPQPIAMEMHSVVNGVLYRHQGYTVDSNSCCTFMGVIHTLMRLYPEVNNQCKIFALIDISGQFSIFNPLHGAWEIFWQMGNWGKVSAFAAPHDEEDDFRARGRRLVVIMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L798</accession>
    <name>U4L798_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935700">
        <property type="protein sequence ID" value="CCX12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L798"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="12983" checksum="155A081632601BA1" modified="2013-12-11" version="1">MLQPIPSPRSPASWNKDMTKKFIDVLLEEIAASKINTETLDSTGHAPTVDAKQAKNKTSTSKKDRDTFLKVKGCSGFEWDPETCTITAPADVKERIIKIVEFSLANLQVDQLTNSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7V6</accession>
    <name>U4L7V6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7V6"/>
    <dbReference type="STRING" id="1076935.U4L7V6"/>
    <dbReference type="eggNOG" id="ENOG502S03K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMAFGAQ"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33362" checksum="53F47642AA459420" modified="2013-12-11" version="1">MFADEKFRHTGIEDVSYTHNGKKLVFVDTPGFNDTNKPDSMILEQVARWLDITYRKGKHLAGIIYLHRITDNRMDVTSSRNLRMFKKLCGPDALKNVCLTTTHWDMVDQRKGRSREVELQGKFWQEMIKHGARTARFDGRAEAAWRVVEPMMNNQTVVLQIQEEMGRQHMKLSDTDAGKTVSKELAKADKEFQEEIAALRKEWQSAVQEKDREVAKVLESERRRAEERLAQTQKERDQFIRMQYEGMKRSNEALLQKLERDNRQYGFLESLGMAFSALIPRFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8G1</accession>
    <name>U4L8G1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8G1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10291" checksum="7CC069EE8C204793" modified="2013-12-11" version="1">MSDWISAALTNDISARVEAVITAECIECRENSMHTFVPHIRAYMIIPAWIVFGVGVGCVGIKILTQVLKCHKYNDREVAKTCPSLYHSLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8I5</accession>
    <name>U4L8I5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935904">
        <property type="protein sequence ID" value="CCX13891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8I5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8874" checksum="D63A2362D05D4281" modified="2013-12-11" version="1">MRTEYEPLTTLRESETDMPVEYYELSITLREEEKLVESVMTNANDDPTALVEEFQFDEPVDERREQHFHMCIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8U3</accession>
    <name>U4L8U3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to mRNA 3&amp;apos acc. no. Q4IPA4</fullName>
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    </protein>
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        <name evidence="1" type="ORF">PCON_06121</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935294">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="34128" checksum="73CD58B2B1981B89" modified="2013-12-11" version="1">MSTGTKLEKEYNKHGTEEIEADTEEKLIDDGYESAGYVGSTSSLRSAVGKYLMNGRLHLAPIDTSNPQRILDLGTGTGIWAIDIADSYPSAEVIGVDLSPIQPQWVPPNCRFEVDDIELPWTYQANSFDFIHSRNLEDCIKDWPSLMSSIYRCLSPGGYFELVETTPDALCDDRTLPSDCSLRKALDYYQEGMKSAGRGNFVTPTILRERLEAAGFESVQVVTVKQPIGSWPKERRLKRIGALARLVYTAGLEAYANAVMKRFLKVEADIVDGLVKGAIEDLKNNRYHTYNYLHIAYGRKPKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA11</accession>
    <name>U4LA11_PYROM</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    <dbReference type="OMA" id="WESLHAS"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="201" mass="22253" checksum="31B5C54B0065908B" modified="2013-12-11" version="1">MDEQGNKAKSLVCEACWNGLFSFDAWQIVLAGTEQPGRVGYSNGYCYTTTWESLHASSAAGCSWCKFLCHPEYTNGGVEIWVACDEDSECTPAGTKKLTVKLESSGGRAFSLQHYYMYTTDGDHAGRFIAARERVVDIASPTGYRLALECLDSCTRFHESCPKPQPTTLPDRVIDCSNPEKPRIVITNGKLQGYYVTLSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA18</accession>
    <name>U4LA18_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936243">
        <property type="protein sequence ID" value="CCX15611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA18"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6614" checksum="D1782EF359249DFC" modified="2013-12-11" version="1">MISGGREMYHGCRMDSFLRQPSKFPGILERVSPDMSRFSLYITQESDDNIYGDWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA40</accession>
    <name>U4LA40_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936044">
        <property type="protein sequence ID" value="CCX14769.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA40"/>
    <dbReference type="STRING" id="1076935.U4LA40"/>
    <dbReference type="OrthoDB" id="8063676at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21728" checksum="FDA0393BF11B79EA" modified="2013-12-11" version="1">MSSMSIRNGVSKSSDGSSVYRVPREQQATHATFQEGRIILLTEYNYREWSQACRHLLGSMGLWEIVQRHETPLDDAIYLKRKGQAQWIIYASCSIPIRVFLDGENEPAKMWQILKDNLDPVMTRHGRHYLAKEFDESSPKPQESPKMYAARLRVFQNQLMGTQEQISDADIKTKMRKWFPSHTQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA47</accession>
    <name>U4LA47_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LA47"/>
    <dbReference type="OMA" id="TESAFCE"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1437"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1834"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1963"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2156"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2247"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2305"/>
            <end position="2528"/>
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            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
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    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
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        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="190"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX15867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="457" mass="51595" checksum="83E9841ACF4A35F3" modified="2013-12-11" version="1">MPANEDPSPMGITSILDTDLYKLTMQWAVLKSYPDADSTYSFTNRTPDLKLTRKGFNWLQEQVSKLSQLALTDDEEEFLAQKCSYLPNEYVAYLKQFRFRPDEQVTLTFTPVHEFTKRAEEEEGAPDHTEFGDLSISVKGKWVEAMLYEIPLLVLVSECYFRFSNTDWDYDGQEENAYKKGLQLLSNGCTFSEFGTRRRRSYHTQELVLTGLLRAQKEYAAQNPDGNGMLAGTSNVHFAHRFGLTPIGTVAHEWMMGIAALTDTYTSANAIALENWVKCFGKNLTIALTDTFGTPQFLECFKKKCEFVDPPQSYAEIFAGTRQDSGDPAKFVKLMRKFYDSQGITERKTIVFSDSLDVEKCLEYKQVAEEHNFATSFGVGTFLTNDFVHRSGELAGKKSVPLNIVIKISSANGKPAVKISDNIGKNTGDAKEVERAKAEIAYSETTWEDGDESHRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBB2</accession>
    <name>U4LBB2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936535">
        <property type="protein sequence ID" value="CCX16896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBB2"/>
    <dbReference type="STRING" id="1076935.U4LBB2"/>
    <dbReference type="eggNOG" id="ENOG502SSWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIHYGAY"/>
    <dbReference type="OrthoDB" id="5313288at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="234" mass="27743" checksum="8E9E63876C79534B" modified="2013-12-11" version="1">MTRILDLPPEILNNIFDYLISTADPKKPQSWDRHEVRQPLNRLALVSRAFRDHVEAYCAHQIAQLAARTKTSLPLHHCRKPRTYRKHYLRRVIYHCEFCQVKTSCRAMVFNDIVCCRSCDRKIWPEKMTKTAARTTYDLHDHQLAKIQSGRYQVYGMISTMYLTSDVKKLAESIHGNLEEWKKKKKEKLKRQREIREEEERANYEGDFGVDSYAFGGPDDIDYNDYNHETLADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBH6</accession>
    <name>U4LBH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Protein PET100, mitochondrial acc. no. P38958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBH6"/>
    <dbReference type="STRING" id="1076935.U4LBH6"/>
    <dbReference type="eggNOG" id="ENOG502S1QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKLPFRY"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="9251" checksum="4DD506ECCBC749AF" modified="2013-12-11" version="1">MGGSNLEVFKFGMYIMFPIAVMYYFGTNLDQRFSVQGFWPDANATHKIPHEREEILSELERMKQRRLEKKFKREEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBY2</accession>
    <name>U4LBY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to rRNA-processing protein fcf2 acc. no. O42877</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_05685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBY2"/>
    <dbReference type="STRING" id="1076935.U4LBY2"/>
    <dbReference type="eggNOG" id="KOG3100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="3">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="257" mass="28830" checksum="60328CEAF72936D6" modified="2013-12-11" version="1">MSSTTLSLDDFNFTPLHKRARFVSNDSLTDNSNALATIPSYDSDDEDLSDEQIAALIRQGAEDMKNGAATPAKPKAPFRIPKLETGPLPEAHLYTDNNGIVRVKPIVPEATRKALAQLPTLAAATAGAKKNEPAPTAGDKWYGLPRTVLTDEFKRDFTLIKHRNVLDPHRHYKKDKSGIPEFSSMGTVIEGNTEFFNARINKKDRKKTILEEVLADKSGTARFKRKFEDIQQSKKSGKKEYYKNLKEARNKYAKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCC6</accession>
    <name>U4LCC6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935384">
        <property type="protein sequence ID" value="CCX07972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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        </source>
    </evidence>
    <sequence length="275" mass="30399" checksum="6AA4E6858E0E061E" modified="2013-12-11" version="1">MVESRKERKSFAKMRNSTQGSIPLAAMSTQRKEGCHAQLEKRPLPLSPEGRWHGSELRAGLNMERTWMTGETEGREETEGGRGKEGVRQSADATNTYAAAAASYCKVVIDFPGSSPGVEKREHHHAENEQQPSSQTEQAERKRLRSLTTAHSSYRHLTVPSPPTPPPTPSLYFHPTPNTSNYVSFSPPLKHPRSPFHTCQSNPYSIDAAAAGPAAPRTHQAYPPSAVRTINGPIPNLFIVQKPAKQPRSTLRRILAGQNRTPPPKKQQKPKPQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD95</accession>
    <name>U4LD95_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proline--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="4"/>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD95"/>
    <dbReference type="STRING" id="1076935.U4LD95"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000066">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="80"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="596" mass="66562" checksum="5B2D5C068332221C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDV2</accession>
    <name>U4LDV2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDV2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5337" checksum="7B0E79DBC7DA23F9" modified="2013-12-11" version="1">MAHPFAVTHTRTLRKASIVQAMVGLRHEHSHLPQPPSFKTSSASARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE09</accession>
    <name>U4LE09_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935457">
        <property type="protein sequence ID" value="CCX09324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE09"/>
    <dbReference type="OrthoDB" id="5499532at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="50955" checksum="201BCF0FBE8F9BDB" modified="2013-12-11" version="1">MMQPDHGTPLPPREVVASRAIEAYRESLDMPPSSSVDQSRQGDDTPILQRPMLLPAPVTAAAQGMANLPIQFTQWMATRRMASLRSDAAPSSLGVVSESPVPVRSSTQETTAQPVSQPLKKQPDAATIIASSTAEAHATTKKPRQPHKTTAKATKPKKAATVASAPQTAGATPDSVNDPVFLKQHKISWMWTRDEKEKILNWLGDNLANYQTWKMSQEKTAEKLSVLLFDGLRSGPAIRNQWVAMKDKHQKAKAKMMATGGGAIDPEDEMEPEKLVWLEGICPLYWKIDNVVQRDKSIYSNFVGETGKDGHIGIVQSKHKVDPVKINVQDKEGDDCHPPVGGSKDPRKRGGPSGEGELTLKKTKLSAADKIIHDYTVNVKAFQERQLEIQEKQLERLMQKDAWKEKLEETRMNLKHEREMKRLAIAEEEARSKRLMLELELAKVHQAAGNKTVRDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEP5</accession>
    <name>U4LEP5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Bifunctional purine biosynthesis protein ADE17 acc. no. P38009</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935458">
        <property type="protein sequence ID" value="CCX30604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEP5"/>
    <dbReference type="STRING" id="1076935.U4LEP5"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="615" mass="67186" checksum="D3CA1037DE48FD8A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEQ7</accession>
    <name>U4LEQ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEQ7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="8426" checksum="4758BDF0EB7438BF" modified="2013-12-11" version="1">MRMRELVRSDKNKLQSQCRQTPLELHEYLGLNFNSYISISICISLICMSKQFFDLCRAGEAQTKHRDHHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFC6</accession>
    <name>U4LFC6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935521">
        <property type="protein sequence ID" value="CCX10202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFC6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7225" checksum="AE12A35E3FAFA168" modified="2013-12-11" version="1">MFPDFRFVSPALMIHHKFTTLEEITVYGGISGYKYFRRDPVEPQKGAEVSTGSKHRLASSHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFF7</accession>
    <name>U4LFF7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative ATP synthase subunit epsilon, mitochondrial acc. no. P87316</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFF7"/>
    <dbReference type="STRING" id="1076935.U4LFF7"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKYTQIA"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7201" checksum="FE45FE3F3615A4BC" modified="2013-12-11" version="1">MLAASWKAAGFSYNKYLSIAARVIRKSLKEEARLKAEKRGPLELKFAKWENGKQGEAQNLYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG51</accession>
    <name>U4LG51_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7055" checksum="B108115BA3CC9941" modified="2013-12-11" version="1">MYDGGDGGGGGGVAKTETMSGQGSTPHSAFSISWTSLQLLLHLINIHIDLLDPEPAFPLCPNGQCSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGM3</accession>
    <name>U4LGM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGM3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="7985" checksum="250EFB500BFCC2C3" modified="2013-12-11" version="1">MNERSKKRVTKNTLNDRKIRKNTSTQLAAFWLLRGRGQWVSAVVLHVAWKGHFTTSPKLARVALALAMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGX7</accession>
    <name>U4LGX7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935591">
        <property type="protein sequence ID" value="CCX11098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGX7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="44" mass="4764" checksum="55BDCDFB4212AEA4" modified="2013-12-11" version="1">MGHLRPGDLPTCSSRGCASIQYTAVAAALPETHYSRPRGYVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH24</accession>
    <name>U4LH24_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_10756</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LH24"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="567"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="16">
        <location>
            <begin position="2330"/>
            <end position="2657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="133"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="352"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="634"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="831"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1233"/>
            <end position="1347"/>
        </location>
    </feature>
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        <location>
            <begin position="1399"/>
            <end position="1425"/>
        </location>
    </feature>
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        <location>
            <begin position="1818"/>
            <end position="1856"/>
        </location>
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        <location>
            <begin position="1873"/>
            <end position="2049"/>
        </location>
    </feature>
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        <location>
            <begin position="2066"/>
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        </location>
    </feature>
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        <location>
            <begin position="2151"/>
            <end position="2265"/>
        </location>
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        <location>
            <begin position="2106"/>
            <end position="2133"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
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        </location>
    </feature>
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            <begin position="2214"/>
            <end position="2223"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX31409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2722" mass="300292" checksum="61DCCD792DCA1283" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHE7</accession>
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        </submittedName>
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    </gene>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="258" mass="28794" checksum="C26E4C8F8E68D6E7" modified="2013-12-11" version="1">MTTEPHLPRIPRFAESLISDMFTSARRSFSDISMRNYRIFIFLIFAYLLHHTQARPRYEVIVDSPLCESCDAPNSASDGSIITHMSSEYHLSITPDEATETLPSEIVVDIPIGKSGESHQTIVSSSGEILSREIFVNISPSKSNERHQTIVTASWRDSSIWSSIEDTLSKYRWSMMSDGERYGCITIVYISAGILVSIICGLCDVLCWVFAGRKPNIKQAATFDMESAGEHVASEADDMQFSQIWNAPRSGKVPGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHG9</accession>
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        <submittedName>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
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            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21273" checksum="DCD40DA9194100C4" modified="2013-12-11" version="1">MASTTAPGAAAPIVFTAEQTQKWELGVSLLLNFWQPLRDAVSCNWGGPDSADKRDWLCGVIADLWTEDEEADEETVEQRLLQVMEDEFDVNLEDDSAYDVGKQVMVLRTEIAENNFANVDALHQRFLSRPSNSANAPVIQDVDQDAGSSDEEDDDDEMEEAPALVQTRERQERVVDDDGFELVQKPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHQ7</accession>
    <name>U4LHQ7_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LHQ7"/>
    <dbReference type="eggNOG" id="ENOG502SEK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KAFFFAK"/>
    <dbReference type="OrthoDB" id="3945378at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652324" evidence="3">
        <location>
            <begin position="24"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="357" mass="39988" checksum="4816B9540B242754" modified="2013-12-11" version="1">MNLPPITAVAFLSVLFGTTVVNAREIAPAGPGETCGFEGNADMYGLGIRLGVYIQAFATTLSGAYRQESSRGASFANGFFQFAMFVALVYMTVINRELEVVEAAIIILFTFCSVSISNPEDKEALRKPEGIRLRDIRKFLRHSFVPFGKMLTELALNLYWTWFWFLGIERQQLSPCTGYGFFFSKVSLFGWFRTLATVVTVCMVVWDTFVILRVLYSKPPLPSWITSITEFDPNATKKSIVCMRDFAGLVISLAIIGFYILSVESMILWNNIRNVNVILGSVGQMIPFLVGLGSFIAVILEWNVKPECNNCKQDIMKDGNPRNGVIEERKEEKVCDPEKSGLTVKQEEITPAPEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHV4</accession>
    <name>U4LHV4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHV4"/>
    <dbReference type="STRING" id="1076935.U4LHV4"/>
    <dbReference type="ESTHER" id="pyrom-u4lhv4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FECPAAR"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005147636" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="20"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX16243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="472" mass="51528" checksum="B6D0A5CA2498F024" modified="2013-12-11" version="1">MLLLHILPLAIVIVAQSADDLLVSTQSGPVKGHYVPGKPTVREFLGIPYGAPPVGDLRWAPAIQPPRWNTPLEAKAFSPACYNVVPTGYDLGASPTIVNTPKPFAEDEDCLSLNVWAPTAARLKYGGAAVMLWMHGGAFARGGAFISVYNGANIVRDQEDIILVTFNYRLGIFGFPGASVFGNKANPALHDVRSAIEWVRDNIASFGGDPKKITLFGFSAGGTATEIYLYSHEKDPIIHAAIIESSTITIRQQNKTVATGEWNKLAAGANCTHTSDYEQLACLRAIPASRIREVANVNKLSFIPVPDGGPFKTDNEVRLRSGRFSHIPLLVGNNNEEIQTPGIGVADTQGIFTCTSARSARFHAHYGKTWQYRYFGNFPVGNWTNPGAYHGSEVEQVFGTYLEKSATYFQRKSSRYMQAVWTAFAKDPINGLSRLGLPTYNAQRKTLIRLAYENVPGATLVRPGEYEDGCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIJ7</accession>
    <name>U4LIJ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIJ7"/>
    <dbReference type="OrthoDB" id="10421842at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="840" mass="91800" checksum="8A6C4E0C5A677187" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJQ6</accession>
    <name>U4LJQ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to DNA-binding protein Ikaros acc. no. O13089</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935806">
        <property type="protein sequence ID" value="CCX32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJQ6"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="16436" checksum="4CA46C7D9712BC35" modified="2013-12-11" version="1">MADEDQQQQPPRFPVFHRKGHTVRLDFPPTNCAWKLDDGTICNFPCERRFEFRDHLIETHGVGLTSRPHVCKDCGRGYSKPKKRGQCSHDNPNVLPISHLDWSRLEQMLLDLEAALNQVGRSDTAVDEAIAIVRKANAEDSTVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK14</accession>
    <name>U4LK14_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK14"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4231" checksum="D71E0FED15E191BA" modified="2013-12-11" version="1">MAGVNGASMGRRGRVRRRARGGGTDGLGWREPESCNGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK59</accession>
    <name>U4LK59_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK59"/>
    <dbReference type="STRING" id="1076935.U4LK59"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDERITM"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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            <end position="1019"/>
        </location>
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            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140867" checksum="B1E34C3E959A490B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKH0</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX29855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4871" checksum="CF5F0DDFBFC0EFF1" modified="2013-12-11" version="1">MVRRRWLISVWWRRLSIIPLVSAWKLQFQFSHDHHNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKU7</accession>
    <name>U4LKU7_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_12523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX32202.1"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8136" checksum="C2A208977D692BBD" modified="2013-12-11" version="1">MSDLPLDETSFHIRPAVPNGSCLLPVAFRDAGKSVPDFISFAFTRRPVPPTTDRSACWATLLSAYDVTNAPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL40</accession>
    <name>U4LL40_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Lysine-specific demethylase 8 acc. no. B5XF11</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_13200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LL40"/>
    <dbReference type="eggNOG" id="KOG2132">
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    </dbReference>
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    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF101">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="272"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="386" mass="42737" checksum="677EF3224984A893" modified="2013-12-11" version="1">MSSLSIAVLDAATLVIEDHSDITECGEGTVQLLTRLADAILSASSSSSETETRESHLARTEDLLRLARQKLHAYPFSSVPLCWRALFTDASILKACLQIAVLESSGSNDDTPIIHTLDTALIMAGSPGMGRREAIEQILSELDSSYPAVDAEEIKFDTEKAEAPEITHPIPRLKEPSLELFQRLISTSNKPIIMTGCLEHWPAMEDRPWSNPGYLLSLTNSGKRLVPVEVGKTYTDASWSQQIIPFKEFLSTYMSPGDNLTPGYLAQHNLFSQIPSLRNDIAIPDYCYSTPPPPPPNVKETELLDEPTINAWYGPRGTVSPLHTDPYANCLAQVVGRKYVRLYEPGAQVYPRGRDQRTGVEMGNTSRVDVEGGGKRRKKERREARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLE7</accession>
    <name>U4LLE7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Ankyrin repeat domain-containing protein 50 acc. no. Q9ULJ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935902">
        <property type="protein sequence ID" value="CCX13889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLE7"/>
    <dbReference type="STRING" id="1076935.U4LLE7"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NINPNCQ"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="320"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="914"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX13889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128110" checksum="C3DF49E875804E59" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLF6</accession>
    <name>U4LLF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Cytokinin riboside 5&amp;apos acc. no. Q8LBB7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLF6"/>
    <dbReference type="STRING" id="1076935.U4LLF6"/>
    <dbReference type="eggNOG" id="ENOG502QSR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="24758" checksum="C92FCAEC1D611D1B" modified="2013-12-11" version="1">MTMTESAKKPFKVAVYCSSRHGSEKVKDSFRKAAEGLAQAFYGKSWGLVYGGGTKGLMGAVAGTLSNLGGSIDSVRVSALLDTEGASLYGGPENYGNEIMCATMHERKARMEQEADAFVALPGGFGTLDEFVEIICWSQINIHSKPIVIFNIDGFYDPFFALADKFKDAGMMPEGAEDIYRRANTVEEVIRAIENYEAPSEGRLKADWSQKAKVPNPVLGSSASMNNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLG6</accession>
    <name>U4LLG6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Putative HC-toxin efflux carrier TOXA acc. no. Q00357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLG6"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YYNPWLF"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="542" mass="58534" checksum="B854754EFF1760F6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLW5</accession>
    <name>U4LLW5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_14179</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLW5"/>
    <dbReference type="STRING" id="1076935.U4LLW5"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QMIQKAR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="216"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="500"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="787" mass="88323" checksum="D2B509B495A6B091" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM67</accession>
    <name>U4LM67_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Transcription initiation factor IIA large subunit acc. no. Q9USU9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_08629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM67"/>
    <dbReference type="STRING" id="1076935.U4LM67"/>
    <dbReference type="eggNOG" id="KOG2652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EVCDASQ"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="393" mass="43714" checksum="B4F2C49C64EC55B5" modified="2013-12-11" version="1">MSNQLVGQVYSSIIEEVINSSRIDFEEAGINASTLDDLKAVWRNKLSGLKIAQFPWDPAPAPEPAPLAIGTAVSQQQRAQQQQHVHHAQHMMHQQQQMPQQGQHMVVPKQEPYTQLGNGGVKIKSEPGMEQSGVYTMPVAANLAGNPTHDPHLAQMRAQQNIVQKFGSQLQTRPQSGLVLPAMNAGPPPQPQPQRTQQTGMQQHDGADDEVISIEGFGSLSREQADNVLLSRINQAERASAKATEDLFLALQNLKTTDPSPKFKVKGKRKSKARRVHRDPYDEALDPNSSYPYPATVEETFPSAAQAPRIPQGDATADSDDENDEDAINSDLDDPEDDEIDNDDEDEVPQRMLCMYDKVQRTKNKWKCVLKDGVLTINGREYVFHKANGEYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMW3</accession>
    <name>U4LMW3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to selenoprotein domain-containing protein [Metarhizium anisopliae ARSEF 23] acc. no. EFY98853</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMW3"/>
    <dbReference type="eggNOG" id="ENOG502S6UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYCTQCR"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="15933" checksum="9B7E16273B19A4BE" modified="2013-12-11" version="1">MSANIYPRVTIAFCTQCKWLLRAAYFAQELLSTFSTSLGEVSLQPSTGGTFVVTIQNDKDSEPKVLWDRKEDGGFPETKVLKQKVRDVVDPGRGLGHVDGKKEAVKAGEAEEGTPLAGEMDGKKENVLLVGEKGPACEPGEKCEDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN66</accession>
    <name>U4LN66_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN66"/>
    <dbReference type="STRING" id="1076935.U4LN66"/>
    <dbReference type="eggNOG" id="KOG2675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KSQQTHK"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="379"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="537" mass="57777" checksum="16D87E6343A843A7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN75</accession>
    <name>U4LN75_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 12-oxophytodienoate reductase 1 acc. no. Q9XG54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN75"/>
    <dbReference type="STRING" id="1076935.U4LN75"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="390" mass="43081" checksum="41C5406DDDB9BEBD" modified="2013-12-11" version="1">MPAALADTKLFTPLKLGSITLKHRVIMAPLTRVRSPEHIPGENVLEHYKQRASDGGLIITEASHISVMGGNYHGAPGIFSPEHKRAWKKITDAVHAKGGYIYCQLWHVGRAAHPDCLGGRKALAPSVGKIENGVVYFTAKGPQPYTEAAEMTLEDIKDTIEDYVHAAKLSIEAGFDGVEIHNANGYLLDQFICDNINKRTDNYGGSVENRARLTLEVIDAICAAIGADKVGIRFSPFGFYQDTQTSDIIGHYGYAMQELDKRGLAYIHLVEPRQDATGSEEAKIARLRELAKQRGQSEENLLSIRPFRDIVKNTVLLTNGCFDAENAVPTLENDQADGIAFGRYFISNPDLPARLANGHELTPYNRDTFYTPGNEGYIDYPEYSKTQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNC8</accession>
    <name>U4LNC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNC8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17175" checksum="869A6294D0DAADF2" modified="2013-12-11" version="1">MASSPIPKSGNLLRTPVGPRYHDGRQGSSQTIRTELSLIGGLSPSRGSFDDDIFYTPREHRYSGSEYPPGQVPAVLPPPRSRFTKHVDAANTYKCNIDDDASPPRVRASAIRKSETMTAAGQSMFPRLDNTEHSPPKSATQTTRPVTLVSQILRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPW8</accession>
    <name>U4LPW8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_03451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HF936502">
        <property type="protein sequence ID" value="CCX16710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPW8"/>
    <dbReference type="STRING" id="1076935.U4LPW8"/>
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        <location>
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        </location>
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        </location>
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        <source>
            <dbReference type="EMBL" id="CCX16710.1"/>
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        <source>
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    <sequence length="610" mass="68687" checksum="5EB58E323C1E7F7E" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
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        </source>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </feature>
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            <end position="38"/>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="12947" checksum="4CB7A2C4B54A8938" modified="2013-12-11" version="1">MSHPFSPSVSSSEDTYEEPPMSPHSMDYDYDSNTPNPDPVEAILTYGKLRATKSNSIEGFRITRKSSQVPRFIVHPQPKLGLRDSIRNKSGVQVCSRCGDEGHGARNCDNYSAVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQV4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQV4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8963" checksum="F7E3A0BDA2F8BFA4" modified="2013-12-11" version="1">MEVLFNCYNYRGSCVHRCTAFPISCPRRRKVPEQHLLEDMQAFCLYFLRSRYFHFNSSFRFPEFLSPCGGGGLSGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQW6</accession>
    <name>U4LQW6_PYROM</name>
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        <submittedName>
            <fullName evidence="15">Similar to ATP-dependent bile acid permease acc. no. P32386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_03974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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    </reference>
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        <subcellularLocation>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="2"/>
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        <location>
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            <end position="46"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="129"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="155"/>
        </location>
    </feature>
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            <end position="186"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="219"/>
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            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="993"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1181"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1272"/>
            <end position="1290"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="654"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1360"/>
            <end position="1609"/>
        </location>
    </feature>
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        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="902"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1641"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="939"/>
            <end position="957"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
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        <location>
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            <end position="1651"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1652"/>
            <end position="1671"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1681" mass="185516" checksum="B32BF04177D1A5C4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRE9</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="6" type="ORF">PCON_03928</name>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030488">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="230"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="673"/>
            <end position="908"/>
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    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="910"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1487" mass="163755" checksum="96DC60939DD734D0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRF6</accession>
    <name>U4LRF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 26S proteasome regulatory subunit rpn10 acc. no. O94444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRF6"/>
    <dbReference type="STRING" id="1076935.U4LRF6"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="31441" checksum="341FCF5330D2649C" modified="2013-12-11" version="1">MVLEATMIVVDNSESSRNGDYLPTRFEAQADAVSLLYSAKTQANPESSVGLMTMGGKGPEVLVTLTTDYGKILTGLHDTKIKGEAHLATGIQVAGLALKHRQNKQQRQRIIVFVGSPIAEDEKTLVKLAKKMKKNNVAVDFVNFGEVESDNTQKLQAFIEAVNSNDNSHMVTIPPGPQLLSDRLLATPILGETGSSESGAAGADGGTAGEGSSGFEFGFDPNLDPELAMALRMSMEDEKARVAKAEKEKEEAEKKAAGEGSSNLDSVKEEDENTPLLKDDKKDKKDDDKMDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRR7</accession>
    <name>U4LRR7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRR7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652337" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="90" mass="10291" checksum="D7A458E77029508A" modified="2013-12-11" version="1">MKFFQTALIFILPTFALAAVAVKRPAEGAPILFWYSKKVPNPAEKRDIPFILYERHDESNERCVKPDEPCKKSKECCISGRCIKGVCTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSE6</accession>
    <name>U4LSE6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Caffeine-induced death protein 2 acc. no. O74982</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSE6"/>
    <dbReference type="STRING" id="1076935.U4LSE6"/>
    <dbReference type="eggNOG" id="KOG4613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QFCFNER"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22581" checksum="C764836A79535B5B" modified="2013-12-11" version="1">MTGTRTPQPPQPAKFAHPPLTPQFCFSTKALKDFLRLSRTSIDDTISQHLNNLSVPSSVPWDPSSTSQLPHLPGSRTLPPSACSNFITSILFPAWQERSDVLNYCASVATSENPNDPDTLNTLASNAAEREKVVDERLDPYSGRYYPKETKTEILKGVVRNERSVEEIVRERTWGVVGERCEGVEEDWRRVLEEWRVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSQ4</accession>
    <name>U4LSQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSQ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="11904" checksum="D4DDC567FD5BA2DC" modified="2013-12-11" version="1">MVLVLDRVDLLAEDEPRILAKWQDFAQQAAVADQLKVVFVCSHERGLKILKEHLPWKSYGPANGGDFQVGDLKDYEANPFVTKAYGNLASKEIQNVVIGFCRTNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU47</accession>
    <name>U4LU47_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_01066</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LU47"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
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</entry>
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</entry>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUQ6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005375898" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="17129" checksum="F06500856238B777" modified="2013-12-11" version="1">MQPSLFLLSLFEELFFLRTILISRQNLSYVERTLSVCYRPGRSPAVAEILHLSRSPPQLHVRTCREVAAQPNRRSLVCNVSSPTECRETPFAVGSECVEWIYQIFPSIATPKIRRQMFSSNSLATHLLELNVRRCHAWVITRHTYSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUW2</accession>
    <name>U4LUW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Vacuolar membrane protein YPL162C acc. no. Q12042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUW2"/>
    <dbReference type="STRING" id="1076935.U4LUW2"/>
    <dbReference type="eggNOG" id="ENOG502S1HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LNCFQYF"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="285" mass="31868" checksum="9A3304664AF1EB46" modified="2013-12-11" version="1">MNTSGAAASIPTGNEDNGRCDLLGPFALVVQGALGAVAFLVLLWKRSRERPQRPFLIWWMDASKQVFGSVLVHMANLLLSMISSGTLTTEPSPTSLVVAAVRRSVDGGDEGYHANPCSFYLLNLGIDTTIGVIFLIYSLKFLNCILELCKLPGFRTGITSGYYGDPPQWGIWAKQSVIYFTGLMMMKFIVFIMFVLFPWLGKVGDFLLAWTEGDRRLQIFFVMFFFPLVMNAFQYWVIDSYIKHPNPYQNLRGEAVPDGPPLLPYNVDESDSEDEAAVHLAQQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV36</accession>
    <name>U4LV36_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV36"/>
    <dbReference type="OrthoDB" id="5437258at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="243" mass="27607" checksum="967D1AA82C77917E" modified="2013-12-11" version="1">MEPPTTYKSIFGPDFDAPPPLPDSRSLSPTESDTKEDLISALKNTDDQAPDYPMFPKFPTDAFSRNSPLFTSTVPDPDPEDRSLAYEEYKRALPGHEKVVLDCTTRATAFRRKLMELGRPTNCPPRDGSTPFDFFIPLYADANKVYSKLCTARDGVKWVHRQMAYLCLTGEIRDREWTQDWADELSQKLAVAESEVKRGADALKALEGHVVVWGRRMDRQWKWRCDAPNAENEGAVGLHLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVU3</accession>
    <name>U4LVU3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_04553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVU3"/>
    <dbReference type="STRING" id="1076935.U4LVU3"/>
    <dbReference type="eggNOG" id="ENOG502S1N1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YKPSPAC"/>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="947" mass="104200" checksum="BC41B89F652DBEEB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW95</accession>
    <name>U4LW95_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW95"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6970" checksum="B34C5248041309BE" modified="2013-12-11" version="1">MPGPDFDLDSINEVYSLEFFRFSHQDIRRILPLLQLDRLVFDNRYKCAPEMAFCLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX13</accession>
    <name>U4LX13_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936379">
        <property type="protein sequence ID" value="CCX34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX13"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="237" mass="26725" checksum="699A2217E902959A" modified="2013-12-11" version="1">MGCHETLMSRRKKSSRPKPSFENAGHNAYTPVVEQKKSLTPTVDLPRDPRDRYRRWRNSHLRNCRLWAYQLMMRIDNLRTSRARKRHSFQGLDQLTANGNPFGDFTGNIPLVLDDSSHVRSFPCSEIKPNDGKITSAYEAERDRNPHIATQDRCYELQAALDKSDIPRISHESTERVERLLNSAGRPISDIGSSKGFKLDEAPENASVSVGGISPPETAAPSPPRDSIVSIPPRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTT6</accession>
    <name>U4KTT6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="HF935201">
        <property type="protein sequence ID" value="CCX04393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTT6"/>
    <dbReference type="STRING" id="1076935.U4KTT6"/>
    <dbReference type="eggNOG" id="ENOG502S0DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF32">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651416" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="359" mass="39221" checksum="DB8EC166329E0D8C" modified="2013-12-11" version="1">MRFLTLLIPILGAGSALAHHMATNIWIDGVNQGAGTCMRIPRNTDPVTNVYSEDMACNVGRNKQEAITCAANAGSRVTVQWRIWPDGSNDGPIDPSHQGPCAVYMKRMGLGGSGAVAGGGWFKIWHDGFRDGAFCTERLRRNGNKMDFSIPSNLAGGYYTLRAESLALHQGGKPGGAQWYIGCAQLFVYSTGGNSQPTDTVSIPGYVDPYHKGVLFNYWLNKTPSNYQIPGPEPRFSIVSSPGKSPIKVPFKPHNYGECVVKNANWCAVSPPRFTDTPGCWASSKNCWDQLDTCYRTAPVTGNSGCREWEKTCTKLQALCHSCRWHGTCNGGSKTKRSILEDRHGRFEKIKAHVAANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU51</accession>
    <name>U4KU51_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU51"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2462" checksum="52BA55DC2B00B876" modified="2013-12-11" version="1">MQLLLSILPLPSILIPLSKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU67</accession>
    <name>U4KU67_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935124">
        <property type="protein sequence ID" value="CCX04220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU67"/>
    <dbReference type="eggNOG" id="ENOG502SB6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RITMIAC"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="312" mass="34144" checksum="478403BC82FE2CCB" modified="2013-12-11" version="1">MFHPLIRCAARLSKPTIRHATASPIRNALASPLRSHNLSALRQSSRIIRHASSKPAPKPALVSPITLTPKPTGDSKPASPKPSPNAPGQNASQLNADGTYPSRILLYYAGKRTVYLGTLKLYAVLLFSYCSLIVAPPLFGQDNADVLGKLGLDNAGVPGWVVPAAIVGGSLVPLVLFQWLSPPYVTHIYTTLPTWATATKSNLFSYLSRLPKDATLEMATIRWFGRPKLTKVTVGDLEFKRARMGCVNTISRARLGDKEQMFYVDWRKSPATVPEPEAVGEVAKAVKKWQDERLALEAEQLAANKKKLGWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUM4</accession>
    <name>U4KUM4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUM4"/>
    <dbReference type="STRING" id="1076935.U4KUM4"/>
    <dbReference type="OrthoDB" id="5379420at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42642" checksum="F933C34089CECFFF" modified="2013-12-11" version="1">MRVGAASPRTRARDGSLKDVVKTIYQNPGDFQDLGMDAENRLTASIPLVLIQSAHKSKALTVPPQKFIAIVDDLQEKMLLVRAWKKLAGNELCEAHGIKPKDLGNAGMFLISVASILDNMQKDKFFNVTGKRNFVGLQMLDIAATMGDPDSTLAMYRWFTRAMAATPNPDEQLRQRLADSSELVKRLAREKNPSAVYEVAKMLEKRGRYAEAKETYIQAGDLGKRNGYAHGGRIINAVEKNVKLAEEIWRIGAQKYDNARCYSYLANLLKEDHPDYERFMTKAAASGIENAAYNLGLFWKTHKKNLEMAKEWFIVAANSTDKSVAYAAFQLKEILKTQNKLDDFGKMVTLKLKQHQELQEVEAQVRRDRRAQKKALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUM9</accession>
    <name>U4KUM9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Nucleoside transporter FUN26 acc. no. P31381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUM9"/>
    <dbReference type="STRING" id="1076935.U4KUM9"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSPWTTK"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="502" mass="54731" checksum="A9C3C3D614B19B38" modified="2013-12-11" version="1">MTQVTRNHDSRSSFDRAQNERDSHFQPSTLHSGRSTAQPKASFSRISLIMSRIVDSVKKSLLGRESQSYQSIPNGDRHSAGEADASRDPISELEQPQKVDMFEYGVFVLLGVAMLWSWNMFMACATYFQGRFAENQFILTYFQSMILGVSTIVNLAVMIYLSYRQSSANYPYRICISLVLNCVTFTILALSTIMFRVSAVPYLVFTLFSVFVAAASTGFSQNGVFAFVNTFGGIYTQAIMTGQGVAGVLPAIAQIISVLLVPSGTGEAGEDGASASPKSAFLYFMTATFVSGLCLCLFLVLLSRHGITIKGQTQPLFTSETDSEDIGAHKSVSLVLLSKKLSYPAFAIWLSFCLTMVFPVFTQAIVSTCPDGSGRAFQPDVFIPMAFLLWNLGDLSGRMACGYDRIVLRNPKMLVAVAALRALFIPLYMMCNVAGKGAAINSDMFYWLVQLGFGFTNGWLGTSAMVVAPDYVDDDEKEACGGFMGLCLVMGLATGSVMSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV17</accession>
    <name>U4KV17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04206</name>
        <name evidence="2" type="ORF">PCON_10930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <strain evidence="1">CBS100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935224">
        <property type="protein sequence ID" value="CCX04992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV17"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8464" checksum="CD5306D3AEC9B647" modified="2013-12-11" version="1">MYDYPTPFNSIMWKRPSSFDLEFSSNFGGWGRIKAGLWTGFMTCGYPGLNFGMASGVGVIACDSGAVIYRLYRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW74</accession>
    <name>U4KW74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW74"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2655" checksum="6927FB4C23DD982D" modified="2013-12-11" version="1">MMLHNTQSTNDTNGSCHTYCMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWM7</accession>
    <name>U4KWM7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWM7"/>
    <dbReference type="OrthoDB" id="5455106at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650912" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="12537" checksum="69FAD182E2E772F1" modified="2013-12-11" version="1">MQFLTLLPIVLTSLCTIATAAPALAPAPAPGGMLSKAAPSYDCHWHVFNTATKVSDRSNGKYACCTENGKEPNGKPKLNCRYNNAICEGGFPKTWCCPASGNISGGQGCQKNFVTTPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWN5</accession>
    <name>U4KWN5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935276">
        <property type="protein sequence ID" value="CCX05907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWN5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4366" checksum="5E41CBD7394AB006" modified="2013-12-11" version="1">MACSSASFPCCTRLNIDDGRFCTECSSICGRVLYSSPDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWR0</accession>
    <name>U4KWR0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935278">
        <property type="protein sequence ID" value="CCX05957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWR0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5312" checksum="4F3C854094FA9FF4" modified="2013-12-11" version="1">MNADTEPRIDLTGHLPTKCRRKTSGTLQGSLFLTLPSLTRVGAVIMSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWS6</accession>
    <name>U4KWS6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935278">
        <property type="protein sequence ID" value="CCX05987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWS6"/>
    <dbReference type="eggNOG" id="ENOG502SFQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHWGGEE"/>
    <dbReference type="OrthoDB" id="5226533at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="8654" checksum="3B421671EFF1A0D6" modified="2013-12-11" version="1">MSAQAAGIRRPSTFLSLAPVSSESYPKSAPEVDASVPISPPLSPVQHRSSSVSSVGEKQRFLKLGPVFWGGVPGQDDFAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX76</accession>
    <name>U4KX76_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PI-PLC X domain-containing protein At5g67130 acc. no. Q93XX5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935287">
        <property type="protein sequence ID" value="CCX06386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX76"/>
    <dbReference type="STRING" id="1076935.U4KX76"/>
    <dbReference type="eggNOG" id="ENOG502RUV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPYLMPE"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650829" evidence="2">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="375" mass="41526" checksum="ACAF673C4EC89D5F" modified="2013-12-11" version="1">MLFPHPLRLLALLPLLAAPVLSYDKTACNNSPSLCSAPYNSLLHLGAHNSAFVRTRENKYSTAGNQYFNVSTQLSGGIRLLQSQLHSDNGAVKLCHTSCQLFDAGLLRNWLKEIKVWLDANPSEVVTILLVNDDKISPNLLAAEYKAAGLDSMVMEPTDKTWQTKTLQEFIDSGKRVVSYLSTGADTNAVPWLMNEFDHIFETGFENTDAAAFSCVATRPGVVAGEDKLKEAVQTRMGLMNRFLYQEISKSLKIYVNNDTYAATVNGDKGVGNLKDGVETCFGQWGKRAGYVILDFVNEGNPAQVVDSFNNVTNPVNRQQFPKNPKDDDKERNQNYASGWDQVEKLAAMARNGTKITTGQWVFAAGDWKGVWDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY54</accession>
    <name>U4KY54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY54"/>
    <dbReference type="eggNOG" id="ENOG502S3VD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVSYYYL"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="507" mass="57905" checksum="F742A5A3BF6E9B15" modified="2013-12-11" version="1">MHARFVPTKHRFRYPLFYVGFPLTQKGSVGNGSFLSIKPSISEIQQAKENGYKIKEWKTAFTVDPSKYLNPSLPFDEKLASILVRHNLNPSDYPHAYLITTPSFLGFCFNPVSYYYLYDRSYTLSAVILEVNNTFGEKHVYFLNATADTNIRPRRGYTFAGTMEKVFHISCFNHRSGSYLVQVKDPLENPKNPQVDMHLTVITAEGVKSMVARAFSVSDSFDILSGGSFRGWKIAAQWGWVNIAALVRTFWEAYKLHKKKTVVYVRPEPLEGSRKREATRSEREMQQLWLAYLKARVMAYPRALEVKVGLPEADPKKTPKEVVFRNGKKVAAGQEMKMLSLRVLNPRFFLRFFANQEVNQTLWLDCTLCSEEHRPVVMEEGTIRELRRLLEGPTTTSPASWTWKAIAKLRSWKTRKEVEASRHLTKTSVPKVHEDEHVNGMDAFYLSGTNACPKARKMYQWKVLYAVVTDVVGFGDAKNVEVYKEILKAGGVTLVASGVVALGWWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYI1</accession>
    <name>U4KYI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935302">
        <property type="protein sequence ID" value="CCX06620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYI1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650956" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="6959" checksum="5108E798CA8EC06D" modified="2013-12-11" version="1">MKFIPYTAAFIVFLSAGVIAAPTASPAIEESAKCPQLMYQCYKRCCGIRLHCYSGSDGKGFCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYN9</accession>
    <name>U4KYN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYN9"/>
    <dbReference type="OrthoDB" id="10565139at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="17391" checksum="141EB529B57221AE" modified="2013-12-11" version="1">MDSEIPEMEQMTLNTHYFKMLTTHLIQMRSTYLKAEPKIRPNFQDFIKELRAKELAVYQFVRPADKLLMFVVWLCEAVTFYKKSREAAVRDRIQAEKTARFAIDEINKLRAQVDELTNKVDSLQTAYLAVMADVEANRKGRRTNLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ91</accession>
    <name>U4KZ91_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribonuclease H</fullName>
            <shortName evidence="10">RNase H</shortName>
            <ecNumber evidence="4 10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 10"/>
    <dbReference type="EMBL" id="HF935372">
        <property type="protein sequence ID" value="CCX07755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ91"/>
    <dbReference type="STRING" id="1076935.U4KZ91"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ELWYGLY"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000090">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="12">
        <location>
            <begin position="188"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX07755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="342" mass="37058" checksum="B5F64C6109E7D379" modified="2013-12-11" version="1">MEKDMVSGSMKRNRVTEQKFYAVQTGFQPGVYTEWNDCLAQVKGFKHAKFKSFGSVADAQLFVRGHDPSLDPNSSGFKQKFYGVHSGKVPGVYTDWASAEAQVKGVQKPKVRSFPTRAEAEAFVLTGELPDAAAAATPVTTKDTVEAAPESITKRRATVSAPAPAPIPAAPAPRTRASRNAQPQAANNSGLLKIYTDGSALANGRAGSCAGVGVWFSHSDPRNISEPLQGPRQTNQRAELTAILRALQISPLHRDVLILTDSQYAIKCVTVWYHAWVKNNWITSVGRPVENRDLVEVIVGLMQDRRNQGADTRLEWVKGHEGDVGNEGADRLAVKGARKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZW5</accession>
    <name>U4KZW5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat, PH and SEC7 domain containing protein secG acc. no. Q54KA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZW5"/>
    <dbReference type="STRING" id="1076935.U4KZW5"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCANAFA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
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            <end position="307"/>
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    </feature>
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        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="336" mass="36926" checksum="FA9EFD3C395DB4E1" modified="2013-12-11" version="1">MLLERGASNNTETSALLGAISNGHEEIAMILIERETRLKEIKDKKDILLLSAAETGLEAMVNRLLELGANIKAIDEEKWTPLHHAVHNGHDLVASVLVDRGADIDAIDKYEWTPLHRAAYNGHVLATSLLLDRGTNREAIDDDKWTPLHHAVHNGHDLVASVFISKGADIEAIDKYEWTPLHRAAYNGHVLATSLLLDRGANREALDSNGWTPLHHAIDDGQDPVVSLLLDRGANIEAMDDNQWTPLLHAIESGHDSIARLFVYRGANIKVTSANERMPLHLAAIRGLDGVATLLLDRGADIEAIGDKGWTPLHHTVMNYKEAIASLLLDWGANID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L004</accession>
    <name>U4L004_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L004"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="15420" checksum="210CE7BB5606540C" modified="2013-12-11" version="1">MDHHMEDVQSLDEVCQQEQHQDDQYDEKSQEDKHDLQHHNHNHDQQREQPGFTEQDSLTAMIDQARAAREEIIYRKLELAAMKAEIKAAEEIRKRKREFEIMRMEKDDGLFQPLEAIMGEILKRPKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4L013</accession>
    <name>U4L013_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_07882</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L013"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQIWACS"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="18">
        <location>
            <begin position="261"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="17">
        <location>
            <begin position="474"/>
            <end position="566"/>
        </location>
    </feature>
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        </location>
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    </feature>
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            <begin position="1082"/>
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        <location>
            <begin position="1420"/>
            <end position="1518"/>
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    </feature>
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        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="236"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
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        <location>
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        <location>
            <begin position="797"/>
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    </feature>
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        <location>
            <begin position="808"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1104"/>
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        </location>
    </feature>
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        <location>
            <begin position="1425"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1441"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1478"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1490"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX08289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1570" mass="173185" checksum="EA1F28F0099FC256" modified="2013-12-11" version="1"> </sequence>
</entry>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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        <source>
            <dbReference type="EMBL" id="CCX08282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
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    <accession>U4L1P2</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2K5</accession>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935197">
        <property type="protein sequence ID" value="CCX04305.1"/>
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    </dbReference>
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        <location>
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            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="339" mass="39691" checksum="CFA4BEE610D15223" modified="2013-12-11" version="1">MEVSTLPKITPEMVKQIQQLEGQKTSLEKEVEFLRQKEIHLQKEVDKTGQDVFSKDMAMVLKRYYEMEEQFGQMKKEIKQDVKNVLAKKEKKIVQQVQGHLVETEKRMQGNFVDNVKKMQEHVEKRLGETEDHFKQQSAGRVIENEKQIQQKVKESIVEHGQKIRKQLDKCLEDNEKKMQEHEKEVKQQVNQRIEENEKKMKEQTDIILTSDSLMKEATHKAVDAHTIVLGETVNEQGYFTTMIPMKRLPDNMVQITGAYGGGCLYVELDKIKTYDDFKNLIRSVWGLDLKLVGNSSYLIDGWASYFDVNWPGPYLKFKRIIITPYYNCPEEHLVNCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L318</accession>
    <name>U4L318_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized membrane protein YCR023C acc. no. P25351</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">PCON_02273</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCX04435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L318"/>
    <dbReference type="eggNOG" id="KOG2615">
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    </dbReference>
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    <dbReference type="OrthoDB" id="419616at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="437"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="505"/>
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        <location>
            <begin position="58"/>
            <end position="510"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="546" mass="58652" checksum="8B592B0DDF9EE73D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3L0</accession>
    <name>U4L3L0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized ABC transporter ATP-binding protein C20G4.01 acc. no. Q7Z991</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04208</name>
        <name evidence="5" type="ORF">PCON_10929</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <strain evidence="5">CBS100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935224">
        <property type="protein sequence ID" value="CCX04993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3L0"/>
    <dbReference type="STRING" id="1076935.U4L3L0"/>
    <dbReference type="eggNOG" id="KOG2355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="29792" checksum="521BD441EE10113C" modified="2013-12-11" version="1">MNPSAPSINISDLNYNFPDGSCALENIDLHLPPGSRTLLIGANGAGKTTLLRLMSGKRLAPSGSILIGGVDPFKTGLEGVTYLGMEWVLNPIVRNDIYVSELLSSVGGGYYPERRDQLVRILDIDVNWRMHAVSDGERRRVQLAMGLLRPWSILLLDEVTVDLDVLARARFLQFLKEETETRACTVVYATHILESAGAWATHLVRVTLGKVRYYGETQEVIKREGGFGLLEVVLKWLEEDLIERGPRGGKVSEAVSYSDVTKVELNIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3L1</accession>
    <name>U4L3L1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_09761</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3L1"/>
    <dbReference type="STRING" id="1076935.U4L3L1"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTNFRVP"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX10168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="544" mass="62292" checksum="3689A352908C4E30" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L423</accession>
    <name>U4L423_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L423"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="5047" checksum="25F3779690DB0E44" modified="2013-12-11" version="1">MTVDTASLLTRDAHQPLNVFAAGIPVPGFDLRFQYKRSKICILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L472</accession>
    <name>U4L472_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L472"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5426" checksum="02F6ADAA64275754" modified="2013-12-11" version="1">MRGLSTISSYSSSSSFSSHSFFFFAFRYFSNSFSDLDLQPRPKPNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Q0</accession>
    <name>U4L4Q0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Q0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="7697" checksum="52CAF779592C0302" modified="2013-12-11" version="1">MASTLGNVWRYRKEIGGANSLSASARSTPSLKRVLSEKAERQPPSSSSREASKLAFGMKSVYISAAHGKPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4U8</accession>
    <name>U4L4U8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Beta-1,2-xylosyltransferase 1 acc. no. Q5K8R6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4U8"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SDKIFWR"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="320"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="620" mass="69127" checksum="4D7EE7D31C50F365" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4V7</accession>
    <name>U4L4V7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Cleft lip and palate transmembrane protein 1 homolog acc. no. Q6DEL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4V7"/>
    <dbReference type="STRING" id="1076935.U4L4V7"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TLWAHFY"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="667" mass="75540" checksum="51B38374EF3E25BE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Y9</accession>
    <name>U4L4Y9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Y9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4313" checksum="8AD443E2E6C72B55" modified="2013-12-11" version="1">MRNDCAELTLHGELRGKILYSRCVLCVDEVEDELLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5E0</accession>
    <name>U4L5E0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5E0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7195" checksum="0F5770049663FDF4" modified="2013-12-11" version="1">MEEEEDEEKKSASEDGSQDTEVKEDKSEDEAPTRVAPLDDGLMHLNSAAAAAESPSLLCSPFWLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5V7</accession>
    <name>U4L5V7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_11790</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5V7"/>
    <dbReference type="STRING" id="1076935.U4L5V7"/>
    <dbReference type="eggNOG" id="ENOG502SKBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KIDEWAY"/>
    <dbReference type="OrthoDB" id="5371657at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651315" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX12196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="201" mass="21996" checksum="4620E74ABE9BCD72" modified="2013-12-11" version="1">MNLILLPLLFTPGVLGHGFLQSIIVNGVSYSGWAPYSDPYITPLPPRYTRHFPDNGPVPDFTTPDITCKQGNVPIPYNISIPAGSSVKFQWDQWGSSHSGPVMTYIARCPGDFSTCKADTGNVWVKIDEWAYKPDQTPPWGSDKLAANGASWTVTIPKTLQAGNYLLRHEILGLHVAGTRMGAQVNFLIGYLKDNLSNYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6K6</accession>
    <name>U4L6K6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6K6"/>
    <dbReference type="STRING" id="1076935.U4L6K6"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="12">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="13848" checksum="FD08BF2454EA61DB" modified="2013-12-11" version="1">MSADAPNPKAFPLADAALSQQILDIIQQASHYRQLKKGANEATKTLNRGISEFIVLAADTEPLEILLHLPLLCEDKNVPYVFVPSKIALGRACGVSRAVISASVTSNEASELQGQIRGIKDKIERLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6V9</accession>
    <name>U4L6V9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6V9"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="393" mass="44231" checksum="5BA2571F55FAD2B5" modified="2013-12-11" version="1">MAEHTLGLDLISGAQVLHILHDLEEGDTNVQKPVKLIANAEEFQRELDVTYAGGPKAPLSVYLIRNCQWAKKHILCTNSGISANVMLRAAFEEGIVESNDAPITAKAFEATSEQHTFTAADAAEPFSDEDIVFSCKIPYAYLNNSHENSMIELRRKAVCRGTLSLWAHYPTATDNTGCIIIVDDFPGENAAPIKLPFYTNLTRKYVIIRSLVTAFLVADFCNWAKSTTEELLSSTEEQIVMMKAYILRSRPDTTTAMALWRLECLLRMLDKWGTQTSQELAVLYPWWYYENSWSTILGLSTQSICDQAALLTAVETKWNPLRQRVKAEAIPAVEKAMQLLHTVAMLQEARDTAEQGESMRRLTWITFIFLPLMLVAVSDIYPLGEFEAIGRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L737</accession>
    <name>U4L737_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L737"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5437" checksum="C5FCB4706E8E3FB0" modified="2013-12-11" version="1">MQEGQAVKFTLAGKPQSQPGTYVRTLADGQIVVKDNEGKTHVVAPSAVQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L794</accession>
    <name>U4L794_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935700">
        <property type="protein sequence ID" value="CCX12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L794"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7101" checksum="F2FB11A5CB006BB0" modified="2013-12-11" version="1">MTMKMGFKCQLTIDHDAGPLECIIHIMTLLTSPVKCTKYINRSFVATRNTSKRISVSRSVGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7N0</accession>
    <name>U4L7N0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7N0"/>
    <dbReference type="OrthoDB" id="10393791at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651182" evidence="1">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="194" mass="20688" checksum="4BE22705852FB121" modified="2013-12-11" version="1">MKLLSITLSAVLASIALAAPVAQFSSGSDAPESDARHEVDHCFTTQEIYHTLPRSFTLLSNGTALTLTSSNVPTPSSSGLSQVFSLNNGLLTFPGNTAYLAAPLTPLATIRRVVFGTEQQGSRFEARPRCEEKEQGGRYLEVLPSGQDLGGRFCVMANEQGEQEVWVKSRGADVPECVDVTVTVKRGARGDGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7N3</accession>
    <name>U4L7N3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_13276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7N3"/>
    <dbReference type="STRING" id="1076935.U4L7N3"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="264" mass="28460" checksum="AFC7F3E1268A23A8" modified="2013-12-11" version="1">MADAAPAGRGGFGSRGGAGDRGRGGRGGRGRGRGRRGAGKNEEKEWQPVTKLGRLVKAGKIKSMEEIYLHSLPIKEYQIVDHFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVVIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLAVLPVRRGYWGTSLGEPHSLAAKESGKCGSVTVRLIPAPRGTGLVAAPAVKRLMQLAGISDAYTQSSGSTKTLENTLKAAFSAVSNTYAFLTPNLWKETALIRSPLDEYADELRRKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7T6</accession>
    <name>U4L7T6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_05786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7T6"/>
    <dbReference type="STRING" id="1076935.U4L7T6"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEKWPAD"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX06199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="142" mass="16221" checksum="35C6E3F7BCCD5223" modified="2013-12-11" version="1">MVFLRIAAAARPVLRTSVTRAVAPRFVAVRNYSDSHEESFEEFTARYEKEFDSVQDVFELQRNLNNAFAYDLVPSVSVITAALKAARRVNDFPTAVRIFEGIKAKVENKQQYEQYLNELAPLKAELGVTLLEDLYPELSKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8F6</accession>
    <name>U4L8F6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8F6"/>
    <dbReference type="eggNOG" id="ENOG502SUT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX14887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="342" mass="37651" checksum="12AD6EA988AFEEC2" modified="2013-12-11" version="1">MNTTPNIPRPPPLKGIPNFTSAPLFGRTSSILFSAQLLVVAAFVSSILRIFSRRLQRTRFKFDDFCALAAFGLLIVNTLLLVEFNFLGRKSFSDRAGKENGPMKEARRRGDIKLGLKISLAFEVVYLYSCTRRLPLVYTSGLSNIITNTLVLSIPIPLLLRAQLRPNQRLGVLFLYLFGALVILFSALRFVTQLLNVSLPQAMGWSQMELSLALLLACAPMAVKVLAADLYTIERERSRGILWGPGPGPQAGSGQTLGKEGYGAHGGAHGIDLEKEPKTAALDTPTFVKRLMKERDEIIRSSGMNSPIPNRRSWEHMAGVREVAAEPTGPTRVSFDTRAGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8R3</accession>
    <name>U4L8R3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized RING finger protein YBR062C acc. no. P38239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935291">
        <property type="protein sequence ID" value="CCX06504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8R3"/>
    <dbReference type="STRING" id="1076935.U4L8R3"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWDDNYG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="19745" checksum="55C421891554118E" modified="2013-12-11" version="1">MTSYYDDHNIPHPPSTSSSSQAQAPRRAPRLDLDEFFGPSSLGTSSSSFRVLANAISDLPSDTEVQRQIVAALLSDAACGKEVKGLGQEFLDTLERVPKNRLKEDDVCPVCNERFLEDQYPLVVRLPCHKDHKFDLECIAPWLKLKSTCPLDRKELGKKAAAPVVEDSEDEWDPQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8V9</accession>
    <name>U4L8V9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Prefoldin subunit 6 acc. no. P52553</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8V9"/>
    <dbReference type="STRING" id="1076935.U4L8V9"/>
    <dbReference type="eggNOG" id="KOG3478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VQTEFAQ"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX09798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="121" mass="13579" checksum="7CAB5FB67F3D072A" modified="2013-12-11" version="1">MSDSQKLQALTQEFQNIQTELSTVVEARQKLESQLSENQSVQKEFGSLGDDAKIYKLVGPVLLKQEKSEAVMGVDRRLEFINSEINRVETQLAELNAKQEKKKIEIIGLQTQMQEAAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8X8</accession>
    <name>U4L8X8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase complex catalytic subunit sec11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_13106</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4"/>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8X8"/>
    <dbReference type="STRING" id="1076935.U4L8X8"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="22274" checksum="2D8433C1859DC553" modified="2013-12-11" version="1">MDALLDQLGMSELRRLKPRQILGQVLNFMLILASAFMIWKGLSVAADSPSPIVVVLSGSMEPAFQRGDLLFLWNRNLGMNEIAGPPFHENATFKGTQVGEIVVYNVVGKEIPIVHRIVRTHQGKQTPLNLLTKGDNNHADDTELYARNQFYLDREKEVIGSVIGYIPFVGYVTILLSEYPWLKKALLGAMGLLVILQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L947</accession>
    <name>U4L947_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L947"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="112" mass="12172" checksum="8FE4DB4DCBB3B7BC" modified="2013-12-11" version="1">MECLESTPVDLADHQVVPAPGGLGRKSEIIGTSRIMKSQDAALILAFTKDPGVTANTPIEFRFSRAQIATITETSFGKSRQQTLNNQLNNIEKVLKGHLTAVEALCKHPRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L990</accession>
    <name>U4L990_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936107">
        <property type="protein sequence ID" value="CCX14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L990"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="16800" checksum="346E5A778D304B88" modified="2013-12-11" version="1">MVDHNEQQTVNHVNGTAMPPTPTTVMNSAVDGPSSVVLPAVSQNVQPAQVSATAATLPPPANTAVTTTATVQNYGRWPPALVTLKLCGLAADGERLWDDLSHAEKYRAVRKFRLRYPGTGVCETVAYIAGKMQKHENEIRRREVMRAHARNGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L998</accession>
    <name>U4L998_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L998"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2555" checksum="B488FCD7CDDC00BD" modified="2013-12-11" version="1">MFVATRVSLRHCRGIETIYSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA62</accession>
    <name>U4LA62_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936073">
        <property type="protein sequence ID" value="CCX14910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA62"/>
    <dbReference type="OMA" id="CAEREDW"/>
    <dbReference type="OrthoDB" id="5424391at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="387" mass="43188" checksum="4C5F2337DBC8CF5E" modified="2013-12-11" version="1">MNPSPRPALLASRAALRKFTSILQPPMPLTERESDKLLRTVQESFRQKLAASTESTDPISSAYTPSAHLSSVLKMAPFTPSPEEARQQREARIKRYLVDPISVFEEHVALGTATVDLARSCLARYNDAASTEKGGERVLKGLLEAGLLEMPQHFIRNTALSYNLITALMREGKQGLLVKWTLTEDPTAVKKFVHHVERTFGLERAAEVFFAFYERVIEEKGVSTVLGVAGRELCKSAKRGGMSEEKFKRLMETSQFWALSQAENAMIQLRFGGNVAPGIQFFKKADQNPESFWTELPEKRRQKMTQLGIELAQACLAQEKVKEAIGISKIVSKRFADLLGGSISASAEDRAEHDLHARGEAVEHLEVFREMFKDILPKEEKLAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBI0</accession>
    <name>U4LBI0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBI0"/>
    <dbReference type="STRING" id="1076935.U4LBI0"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWSVNIR"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="13">
        <location>
            <begin position="252"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="445"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX07672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="725" mass="80095" checksum="8BB26FA5C2C0E6F4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCX1</accession>
    <name>U4LCX1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to J domain-containing protein spf31 acc. no. O74746</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCX1"/>
    <dbReference type="STRING" id="1076935.U4LCX1"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="218" mass="25428" checksum="002E4B11D97CF6A1" modified="2013-12-11" version="1">MASKAPEKTVDDKEDKDILADLDREANEYAKDAEIQRILNAFKLDAYAILDLQPGVAESDIKAQFRKKSLLIHPDKTSNPLAPDAFDRLKKAQAELSDEKKRERLDEAIADARMLLIRERKWTVDTPDLKTAEFAVDWREKTKTVLIDNELRRRKQLKAQLAEEGREQRKQEAEIEERKRKRENEVAWESTRDNRISSWRDFQKSGAKKKKQKTKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD56</accession>
    <name>U4LD56_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">linoleate 8R-lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_11932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate</text>
            <dbReference type="Rhea" id="RHEA:25395"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:58659"/>
            <dbReference type="EC" id="1.13.11.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.60" evidence="3"/>
    <dbReference type="EMBL" id="HF935699">
        <property type="protein sequence ID" value="CCX12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD56"/>
    <dbReference type="STRING" id="1076935.U4LD56"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEIMEFF"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052878">
        <property type="term" value="F:linoleate 8R-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122299" checksum="1252D24E64EDCFA5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDE7</accession>
    <name>U4LDE7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Putative transporter C83.11 acc. no. O94695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDE7"/>
    <dbReference type="STRING" id="1076935.U4LDE7"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWFRSPT"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="113"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX29873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="494" mass="53720" checksum="6692ECB88E405729" modified="2013-12-11" version="1">MSVRTSTFVSTSLSSSSPYQGKQQLRADGNTLATSSFTSRRTSPAQNGYGYAPPPTSDWKPRNMVANGGNHARTRSISEVIKTSRKRAQSVTAGEVVEKLKAPISYKLILICVLARRYLSSALSNTSAKTILNALPQPVTLTIIQFGFVSGWCILLAVIARYVPAVGQAIPGLQGGLRAPSRQVIYTTAPLAFFQVGGHIASSMATNKIAVSLVHTIKKGMSPLFTVFAYRFIFNVHYNTATYLSLVPLTFGVMLACSVEFRGNLFGVIMAFVGAIIFVSQNIFSKKLFNESAVAADPSIPAHRRKLDKLNLLCYSSGQAFLLTLPIWLYYEGTTLLREYHTTGGIALSTKGKHGAPPLTGLELALEFIFNGTVHFGQNIIAFVLLSMISPVTYSVASLIKRIFVILMAIAWFGNSTTPLQGAGIFLTFLGLYLYDKASDANKKDKALRNQQIKDVEPLLPTSNGQAMSDLKLETVSEMNGNGNAYRFGEEKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDY0</accession>
    <name>U4LDY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935732">
        <property type="protein sequence ID" value="CCX12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDY0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4458" checksum="C03D69F4E4E01214" modified="2013-12-11" version="1">MSNRADKPCARLALAYSGQTIERITKSVCAPIHGHSPARHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE45</accession>
    <name>U4LE45_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE45"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="9785" checksum="A3FC15FB2C2AD9C2" modified="2013-12-11" version="1">MSAAPDHVQHPYDKPTHNITPGVPRDQNIEHDPKNTNRAKKVAPMPESCGKSLKDGVHSGGGSAGHRTFGSGKGPLEHENKLSSAEKGKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE87</accession>
    <name>U4LE87_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized membrane protein YMR253C acc. no. Q04835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935777">
        <property type="protein sequence ID" value="CCX13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE87"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQMALIG"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="47"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="217"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="371" mass="40117" checksum="BB4167B5755A68CA" modified="2013-12-11" version="1">MQSPDHAKQPLIPPNRLTNKYGTNNDDDITPPVKSRPNIQQRFTSYSGVLWILLAEFIGSLNALIARVLETSLPQGRRLHPLTLICWRMTLAFAGCLLWGYYKKVPHFPLGERKLQPLLQVRGIGGFIGVLGFYYALTGLPLPDATVISFLTPTLVGIGCALLPLKETFTRIEIAGAVVSFGGVLLIAQPPFLFGYGDNNPGPTDSSRMVAVAIALVGVCGSATAMTCLRWIGKRTPALIPVTYFSGVGAIASVICLLAIPSLPGIELPQSAVEWTLAMVLGGGGWVMQWALTKGLQQEKGGRGCQIIYTQLIFALFWELVVWGDLPSGMSVIGIAIILVSVVTVQVCKKDESVQREVKKVFPASQSEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEA6</accession>
    <name>U4LEA6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEA6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4585" checksum="6422F9E81E385F30" modified="2013-12-11" version="1">MYFRAYLEQYRYTRFHTCLKKQPRIPAPSQHIARVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF11</accession>
    <name>U4LF11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Vacuolar protein sorting-associated protein 70 acc. no. P47161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF11"/>
    <dbReference type="STRING" id="1076935.U4LF11"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNGMIAR"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
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        <location>
            <begin position="195"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="388"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="646"/>
            <end position="768"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="768" mass="84483" checksum="39F3EC360439AED1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF18</accession>
    <name>U4LF18_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_13134</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF18"/>
    <dbReference type="OrthoDB" id="7791461at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651312" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9371" checksum="DE767427C73B0855" modified="2013-12-11" version="1">MQFSTLLIATIAFTSSAMGAAVGVCPPWREDRHTLLKDNNDCSIFWKCGPRGPVKIHCPKGLHYAPHHQWCDFPERAYCQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFI1</accession>
    <name>U4LFI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFI1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="18163" checksum="36F23AAEE4DEEFB7" modified="2013-12-11" version="1">MCMESPSCRSELTIVVLTASTEHIHSTATVTSIQILSGQSDITPVAQPSSSQTTAAPAAGLPVVKARQDYAPPSTTIISRDYRVKLSIHGSTPDPTSMGTGTKAGIAVGSVARKKTAEPNAEQAQEGQGQRPPVYTPAPDVKQEQGYGYGQGAQNQPVDMMAGPSSTEMEIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG10</accession>
    <name>U4LG10_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Uncharacterized PH domain-containing protein YPR091C acc. no. Q06833</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_14044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935984">
        <property type="protein sequence ID" value="CCX14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG10"/>
    <dbReference type="STRING" id="1076935.U4LG10"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YLTTHNE"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="277"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="904"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="927" mass="101240" checksum="619343C59F2B3A53" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH56</accession>
    <name>U4LH56_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Protein ATP11, mitochondrial acc. no. P32453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH56"/>
    <dbReference type="STRING" id="1076935.U4LH56"/>
    <dbReference type="eggNOG" id="KOG3281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FLQWGFH"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="323" mass="36320" checksum="4A9100A1C178E0C0" modified="2013-12-11" version="1">MSSVFTSKIRPLSVIRSLQLLPRCQRRNAQVVNARFFQTRVDPRVTEKYRQKLEEKLKSEGVNSIEELKEVYKEKIEAVRKEAAVPEIDAVLESGTGTVDAAATASVPPVHAPFNPPPPPSPIAEAARKLSSAPPGVKTLDSFVDVEKLLVHEDPKEIGMIWRARFINDANSLCATLPKETYDEMAKLGKKHPMFLLPLPREDQGVEMHILQWTFPTKDQSTVIFTSLEEYRLKGEFATPHTTLTHHLELSEKKGLVMAQGQVAPDRGVTVAHAQFLVVALQKFYGAFKGPETERRRKMLEMFSSGDENFMLEDLIKEAEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH85</accession>
    <name>U4LH85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH85"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="21" mass="2121" checksum="5B9B038DD95200A6" modified="2013-12-11" version="1">MIRIVPGSGFGTSGGCVRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH87</accession>
    <name>U4LH87_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="8" type="ORF">PCON_02328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH87"/>
    <dbReference type="STRING" id="1076935.U4LH87"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="596"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="800"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="861" mass="97073" checksum="96CD8006D1EE45D1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHP1</accession>
    <name>U4LHP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Monothiol glutaredoxin-7 acc. no. P38068</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHP1"/>
    <dbReference type="STRING" id="1076935.U4LHP1"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDEGSEW"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652319" evidence="2">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX16178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="18017" checksum="53BE859FBA6417B5" modified="2013-12-11" version="1">MITQRRTRSFLLAFSLLLIAGLYLTLAHSTPRSANYLHQLRSVASSEQSTELTKLTDKYPIIIFSKSYCPYSAKAKAILTEKYRIVPEPLVVEIDKHPKGLELQEALEKATGRRTVPNILVNGRSIGGCDDIKDLDALGRLPDTIRNYGGSKIQQVFVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIC2</accession>
    <name>U4LIC2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIC2"/>
    <dbReference type="STRING" id="1076935.U4LIC2"/>
    <dbReference type="eggNOG" id="ENOG502RYS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QNMVYKQ"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="294" mass="33587" checksum="29FCDA6433964682" modified="2013-12-11" version="1">MLPIGDSVIFHDSTFFSRFPDRGTLPLPHDVRAEHLRTPGLKKYETRNPPLVRYTQLNLVVKFGSEVTIAEGQCLWALRKLLSNGPYCVPVPEIYGWRTDGDQVFIYQELVTGVTLADRWNGLEDEEKKHIVQKLKDMVHGLRLLQQDPSDVFIGHIGRQKLLDKTLPTFSLNTAGPFRSVKEFHDWFFGLLRWKNEPYRRDVPDDAPIVFTHADFDPSNIIVPSFGRPEILALVDWHGAGWYPAYWEYSKAIFHGFGLDNLSIIFGCNLQKNGVHHNFAEAWHHVIGCAGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIR6</accession>
    <name>U4LIR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Pre-mRNA-splicing factor sap114 acc. no. O13900</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIR6"/>
    <dbReference type="STRING" id="1076935.U4LIR6"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000015">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="515" mass="58602" checksum="C48C34EBB184EA3B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIT0</accession>
    <name>U4LIT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized transporter C1529.01 acc. no. Q9USN4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIT0"/>
    <dbReference type="STRING" id="1076935.U4LIT0"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMPIQIY"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="559" mass="61355" checksum="714F3574C5F44294" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ11</accession>
    <name>U4LJ11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ11"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="197" mass="21383" checksum="6F54CC3CDB727AB4" modified="2013-12-11" version="1">MSTCQSGFVNYPQSPPSPQNAAVVSQRDAPRPASGWAAINTIPKSKTVTETITLSPRPVIHSDSRSFTDTNGSSQDSSTDHIIDSGNTSGNEADDEYSSSSDSDFSYTFSSDSVSTCSCASSSSSLEFCCSKASEGSYSSDCEACWMRLAQEVRNAGRKKWRRQMIRAAEKYTIGSDKSFITQVMAAFMYKKRMSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK97</accession>
    <name>U4LK97_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK97"/>
    <dbReference type="STRING" id="1076935.U4LK97"/>
    <dbReference type="eggNOG" id="KOG3414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="143" mass="16945" checksum="3F197A04C450EC8C" modified="2013-12-11" version="1">MGSVVLPHLKTGWHVDQAIMSEEDRLVVIRFGRDWDPDCMRQDEVLYRIADKVKNFAVIYLCDIDQVPDFNKMYELYDPVTVMFFFRNKHMMCDFGTGNNNKMNWVLEDKQELIDIIETIYKGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKL9</accession>
    <name>U4LKL9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07702</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        </source>
    </reference>
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        <reaction evidence="1">
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    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
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    </feature>
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    <feature type="domain" description="Histidine kinase" evidence="9">
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        <location>
            <begin position="1983"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
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    </evidence>
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    <sequence length="2070" mass="226662" checksum="08659ED9CBAFD361" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKP2</accession>
    <name>U4LKP2_PYROM</name>
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        <recommendedName>
            <fullName evidence="14">Methionine aminopeptidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_07727</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Co(2+)</name>
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        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="14">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="14"/>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LKP2"/>
    <dbReference type="eggNOG" id="KOG2048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="16">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1193"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX29930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1326" mass="145678" checksum="42504E0748973655" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLR7</accession>
    <name>U4LLR7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Vacuolar transporter chaperone 4 acc. no. P78810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_14115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLR7"/>
    <dbReference type="STRING" id="1076935.U4LLR7"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FAFKQNA"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="797"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="833" mass="93976" checksum="458A2EEA88E08CC0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM44</accession>
    <name>U4LM44_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to G patch domain-containing protein 8 acc. no. A2A6A1</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_14249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM44"/>
    <dbReference type="STRING" id="1076935.U4LM44"/>
    <dbReference type="eggNOG" id="ENOG502SA7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YARMNEY"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="15953" checksum="DEA210B9486B939A" modified="2013-12-11" version="1">MSLPPPLTASAREARFAFYCTLCSKGYSRIHEFEAHENSYDHQHKKRFQEMKAMQKPVFKSERSDDGGGGVMRAIKIEPLGGKKKGGFKSAFGAVEGKKDEGKVLAGGKDPAVTGKKEEAAEQREEESETEDEADAYDPERPTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMB9</accession>
    <name>U4LMB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936128">
        <property type="protein sequence ID" value="CCX15035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMB9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="2212" checksum="2ABD4CE913E661F5" modified="2013-12-11" version="1">MYHRAELDTHNKLDKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMK6</accession>
    <name>U4LMK6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMK6"/>
    <dbReference type="STRING" id="1076935.U4LMK6"/>
    <dbReference type="OrthoDB" id="5376710at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="63978" checksum="FDDCFAD7A51A16CD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMU4</accession>
    <name>U4LMU4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMU4"/>
    <dbReference type="STRING" id="1076935.U4LMU4"/>
    <dbReference type="eggNOG" id="KOG3382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHGWIHH"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="16159" checksum="9D8D58F1C4C65023" modified="2013-12-11" version="1">MSTPSRTLRNLFRIGPKKYFWQMLAIGDTKAGTLVGTDRYGNKFYENVKEELPLRTKWVDYKDWDYDAAHVEPGWHAWLHHLTDKPPGQDPHLMHERRAWEPSSHVANLTWTRGAYKPYSTVKPKIEQWEPVARTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN14</accession>
    <name>U4LN14_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN14"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="20036" checksum="BB4DBD08B3A56D95" modified="2013-12-11" version="1">MVDSTTSSEFPRGRPGDGVGFRQPNSGPFNFESSIRLPIDLPAPLLALGPGQTPNRKNNGPSGSGGLPQLPGATWPKLCVLRRLPVLPDFSWVVLLRRALSMPPWRGCRILPDNSGPFNYEITNHQFSSHVNYNRPTQSPLSSRLSEFILGRVASHQRTKMLRVSAARGSEPKSYLGSLPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN69</accession>
    <name>U4LN69_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Crossover junction endonuclease eme1 acc. no. Q9C103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_14061</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN69"/>
    <dbReference type="STRING" id="1076935.U4LN69"/>
    <dbReference type="eggNOG" id="ENOG502R8ER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14376">
        <property type="entry name" value="CUE_AUP1_AMFR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="957"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="213"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="601"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="749"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1168" mass="129216" checksum="521D64422101A47D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNH6</accession>
    <name>U4LNH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNH6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652210" evidence="3">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17002" checksum="7D1709AF97F8A0A1" modified="2013-12-11" version="1">MMKLSFCTMVAIACAAMAAQKSGNDNNERGTLTQTSLVTVTTAAEYCGPSNTYIVVKPVIDTHGPYLSPEEMSSYSENHRSTMENPTTTSPCSTKPTDWPDVFPSNPYPLYTGPDDAPLAHDELWNSDGPKSESTKHAVVGAIISGALSAVGAIFVGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNP2</accession>
    <name>U4LNP2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_09546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNP2"/>
    <dbReference type="STRING" id="1076935.U4LNP2"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651609" description="L-2-hydroxyglutarate dehydrogenase, mitochondrial" evidence="9">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="418" mass="45137" checksum="9E186EB7298A481B" modified="2013-12-11" version="1">MVSLASLTLRASLLPRAAFASLKPRNPTQPNPSLRLVRRTLASLSSSASSNDFTHVIIGGGVVGLAVSRHLAKHRAGSTLLLERHNAVGTETSSRNSEVIHNGAYYPPGSLKTRLCIKGRRLLYEYCEKHRVEFRKTGKWIVAQTPAQFSALEGVYNHGTSHGIPLRWLSVSETSTREPAIRCEAGALESPETGIIDSHSYMQSLLGSFTEAGGDIALGCNVTGVEKLSGGGYKLRTTTGGEEMEITADVVINAAGLGAVKVGNMILPKEQHRKLYYAKGTYYVPLNKPPKVSTLIYPAPVPGAGGLGTHLTMDLGGNLRFGPDVEWVDREDDLIATEKNMVAAKEAIRSYLPGIGDLRPDYCGMRPKLQPRGGVAGVDFWIKKEEGQEAWVNLLGIESPGLTSSLAIAEYVDELLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP75</accession>
    <name>U4LP75_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936171">
        <property type="protein sequence ID" value="CCX33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP75"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="2915" checksum="52145958B916D7FA" modified="2013-12-11" version="1">MLVTFQLVLGSGEVGYDAWYIHTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP83</accession>
    <name>U4LP83_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP83"/>
    <dbReference type="STRING" id="1076935.U4LP83"/>
    <dbReference type="eggNOG" id="ENOG502QWPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASYYCTY"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651777" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="205" mass="22274" checksum="B819FAB96AC95930" modified="2013-12-11" version="1">MKFSISTILFGLVAASSAAAIEKRTPPNIPSATSAKSMLASIPTRTTDATGYQRSLFPHWITISGQCNTRETVLNRDGTNLSIGSDCYPSSGTWFSVYDGATWTQASDIDIDHVVPLSDAWKSGANTWTTAKRQEFANDLTNPQLIAVTDSVNQAKGDKSPDAWKPPLTSYHCTYARMWVKVKSVWGLTVTANEKSALTSMLNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPU0</accession>
    <name>U4LPU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to AP-3 complex subunit mu-1 acc. no. P53676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPU0"/>
    <dbReference type="STRING" id="1076935.U4LPU0"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LNEMCDG"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="495" mass="53516" checksum="263994880F9A9A34" modified="2013-12-11" version="1">MSAIDALYIFDRFAPTATIILQHEWRSRPSTSPASLLTHYNALPSPRPSLIYIPTTSPPTLLFNLEHSNLLLLSPATSEIEPLLVLEFLHRVVDVLEDYLGSPLVASKIESNYDIVAQLLNEMADDGFPFITEPNALRDVVLPPSLIGKLFSSVTGLPNNTLQSLTPSNTISPIPWRRANVKHTNNELYVDVIELVTATIAPSGRPLSARSNGTIAFNSKLSGVPDLLLTLQAPNSHKQTLGATPNSIISYPVFHPCVRLSRWRDRPGELSFVPPDGKFILASYEVDLLPKKDTNLTLPVTVEMKTAVGHEGDEFEVRVFISTASLVSSGGNGSGNSPAFGSRGGSTRSPAFGSSSNALQVEEVSVTIPLPPQVKTLVATRCSRGEYHHEGREVVWKIPMTGGTATSSTATFRTAIQIRGEEEAEEGEDDAPRKKRMAMAMPRCAIIGFSVKGWLASGIKVDSLKIVGGRGIGEGVKPYKGVKYITRAGGVEVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPU3</accession>
    <name>U4LPU3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPU3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="12089" checksum="300BF2F776619158" modified="2013-12-11" version="1">MAQGSDVASTITRLILEGKTNKYCSLNLILTEKQYLLRVRIGSDIATETGSVNSYRHVSRIYDCGWGWREEPKTDEDGAEDEDEEEDEVEENKSKAEGDGEQERENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQQ9</accession>
    <name>U4LQQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQQ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="21417" checksum="3768EA63C7914840" modified="2013-12-11" version="1">MSSRKAYGVSLITPLAAHYVLYRRPLLACLLRAATPSCLRYVCFKTVEDTLTRSNLPIVHPPTTTEPVRRVPRNRSQPFSHRPNLGSNLRSNLAAVYGQKVCDLVSFKSPALQQPVKSLPQRTCHHPEPLFWNSKRWVGAWADKESEKGRLNQFRKVVGWWGSNAQRQPPRVRKSEIERGRWYVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQU0</accession>
    <name>U4LQU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQU0"/>
    <dbReference type="STRING" id="1076935.U4LQU0"/>
    <dbReference type="eggNOG" id="ENOG502RU2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKTGRNW"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="476" mass="52729" checksum="674AE8BD173D4453" modified="2013-12-11" version="1">MSLEQSYTRFLAAPRRDALADSASFHYITTAVSLNGPDKIVAQLAKEQHDKGTQLKKRVEKPLATVQTGNSLVIEMDTEIEFLTSGANWLPGLDDNFLADHIVRFPVVHIVNFEGTLIKEVRLYWDQANILKQINIIGRTGRNWPIKDGADQIKMIGESVKKQSTTVADSSNGNAPVERSRSSSKSSTSTTRDPSAQNLHLFNPADQQDAPEKPRAPRRESIFKPPNRNLEDIIGESDEAPAQVRPPRSSSAFRPPTRDLEDIIGESNEAPKPVAPPKMRGSFSKGQTFDLASHASKDHEVPAATVEKTPNAKKYKHFEFGNGEDAKPDSSPRPTPVSGKSRNESSWDFEDFNTPEKRPIHVRKDDVRHFGFGDEQPAPLSNVTNALRDARIANNSHFEISDSSPAGPVSAAQRRLDRPGKQQKARSAEPEDDDDDFFAQFGAEKQHTTIAIAGDGRGQATAVKKDWSWDMDQRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQX5</accession>
    <name>U4LQX5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQX5"/>
    <dbReference type="STRING" id="1076935.U4LQX5"/>
    <dbReference type="eggNOG" id="ENOG502SKMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PGLMDAN"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="34404" checksum="CF4316CE98E4817F" modified="2013-12-11" version="1">MTPMHDRTYQWADYPFPLISTPASEAGYTSPFIKSASKMALVHNAILRGLNAMYLQCLYITPSTAPAFLTFCSCWSEMIHNHHLCEETAYFPLIETALHLPGLAEGNVEEHDAFMPGLRAFDAYITSCTPTTFSGERLYEILDSFAALMQVHLTDEILWIQELSRFEGKLDIVEIDKVHAAEVKKRASKTRVKPYLCTNHDVGYEGGIHKWFRPGGWVERYLYSVWNWGAWRFSACNLAGHPRKLLGVRPERLREMRDVEADWRAEGEGRPETGMTGMTLETETETVKEAADSTTTSRRSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQY1</accession>
    <name>U4LQY1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">PCON_03526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936516">
        <property type="protein sequence ID" value="CCX34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQY1"/>
    <dbReference type="STRING" id="1076935.U4LQY1"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="361" mass="40465" checksum="93507437F7875559" modified="2013-12-11" version="1">MKLTQLASIAAHPDRVWQVAPHPTLPFLATASADKSSKIISLLNFNTLTTLDGGHKRTVRSVAWKPNTEDEPVLATGSFDYNAGIWRQFEDEATEKKDWQFLVILEGHESEMKRVAWSAGGSFLATCSRDKSVWVWEEMDDDNFETVAVLQDHTQDVKCVAWHPEDVLLASGSYDNNIMLYKEGSDDWVCVKVLEGHESTVWSLEFEPLKSPKYSEERGSRLVSCSDDFTVKIWTRTEQTGLGSGGGQLPSILRGSQPKEEWECTATLPKAHSRSVYSVSWSKVTGRIVSCGGDGKIVVYEEAEDNEWKIVAEVGLAHGAYEINCVAWSTRYDKDKRGENDEIIISSCDDGKVNFWVLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRG3</accession>
    <name>U4LRG3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04288</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRG3"/>
    <dbReference type="STRING" id="1076935.U4LRG3"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VSHYWNE"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651715" description="glucan 1,4-alpha-glucosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="13">
        <location>
            <begin position="40"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="475" mass="51225" checksum="8FB837EA47571923" modified="2013-12-11" version="1">MRFHTPTFLAFALLAVSVQARSIDKRQSSVANWVANEEPIARSALFRNIGPGGEFSKGVDAGAVIASPSTASPDYYYQWTRDGALVFKVLLNEYINGNTTLETFLKAYASESDKLQKTNNPSGGYSTGGIGEPKFMVNGAAFTGSWGRPQTDGPAIRATVLTKFANMLLDAGQSSYVSGLLYSSAYPATTVIKSDLEYVAHNWQTQGFDLWEEVNSNLHFFNMMVQQRALREGAALATRLNDGGAATYYTQQANAIRARLPEFWSSSKGYLVSTLQTSRDGLDCGTLLGALHGNGAAGQGIYQASSDEVLVTLQALVNAFKPLYPINTASGSPGTAIGRYTSDVYDGVGTSVAHPWFICTFTVAEVLLTAVSEFNKKGSIAVSSLSVNFYKQFYSSAAAGSTYALGSTGFNSIVNGMKNYADTFLAVTQRHAMTNGSLSEQFSRNDGYQKGARDLTWSYASFLTTRWAREGTVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRG6</accession>
    <name>U4LRG6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRG6"/>
    <dbReference type="STRING" id="1076935.U4LRG6"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX29871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="41081" checksum="3F8E049AD34EF0E8" modified="2013-12-11" version="1">MSLTTDPSELTAFPSLPPTLTPPTDAPEPAADTRPSVSTEAVLKPSDPIPSDWEEVSGPEFNTSIGRDVTVPELLASMERIGFQGSNLSKAVNVINSMRTWRSPEGEKATIFLGYTSNLISSGLRETLRFLVEHQHVSAIVTTAGGVEEDFIKCLAPTYLGAFHLDGAELRKKGLNRIGNLLVPNSNYCAFEDWIIPIFDQMLKEQEEDGVSWTPSTMIHRLGKEINDPCSVYYWAYKHNIPVFCPALTDGSIGDMLYFHTYKSSPAQLKLDIVADIRKINSMAVHAKASGAVILGGGIVKHHIANANLMRNGAEWAVFVNTASEFDGSDAGARPDEAVSWGKIKADAKSVKVTAEATIAFPMIVAATWGSAGGTKGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSC5</accession>
    <name>U4LSC5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSC5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="25068" checksum="84CDF2211BD25911" modified="2013-12-11" version="1">MLYFSQLPSGNGEDEQQLSSIDIRASDVLYTIASEGSYMDSAATYPYLAGIAQQTIPPRLPVSQPYLQPYYRGFTQSPSHSHLQSREPNLGHRHQVVNHVPDVRDQFFCEGSFNDIPSPEQYGYNPTQPHRGRHFQNLVPIQIPQYRQGVVERFSDFSITTSEDRQGMGSGRNVRFGDREGSGPSAGASGSGMQFHGHPPPYDFFLGSKFPAGANCSSASGSFLVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSW2</accession>
    <name>U4LSW2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSW2"/>
    <dbReference type="STRING" id="1076935.U4LSW2"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045026">
        <property type="entry name" value="LIMYB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47584">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47584:SF14">
        <property type="entry name" value="L10-INTERACTING MYB DOMAIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="277"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="742" mass="80799" checksum="AC8919070FDA843A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSX4</accession>
    <name>U4LSX4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_13335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSX4"/>
    <dbReference type="STRING" id="1076935.U4LSX4"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INNVVQW"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="68"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="627"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="395"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX32495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114385" checksum="D6F199B805640F47" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTR1</accession>
    <name>U4LTR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Acyl-protein thioesterase 1 acc. no. O42881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_14069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTR1"/>
    <dbReference type="STRING" id="1076935.U4LTR1"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPINQWF"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651659" evidence="3">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="39939" checksum="4FF36235AAE03528" modified="2013-12-11" version="1">MRGCKTALAQFLLLPLFPTPPSATHTQNRMPNNNYPDPFIVNPNGEHTHTLILLHGRGDTGSAFGAGVYITRTSSGFSLASLYPGMKFIFPTTKQRYTTGGAAAGYWWREWFDTTSLIYPEEESERQVEGLREAVAYVNELIEAEVANGIPRERIIIGGLSQGCATSIHVLLAQNERMGGFVGMSGWMPFASRVREICGLSPGFGISAILDSEEPVEVKNDESDDEVVPEEGDFPEPPPEKRKEAMMFIREVLLGRSPPGDDEDELEVLKTPVFLGHGDEGLLYPSDSSRERRLHESDEVVDYKLGRNIYTTLRHGLGMDVTWKRYRNFDHWYKEPDEIDDIVDFWGEKCDLFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTY0</accession>
    <name>U4LTY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTY0"/>
    <dbReference type="STRING" id="1076935.U4LTY0"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="373" mass="39833" checksum="DD38DD4AE5D3B5C2" modified="2013-12-11" version="1">MVIHERQISGAGQATGTAPCVNVCWNALTEAQMVGKTSALCRKSSPFRTLLNDCQKCNTQNNTFLSSTLLSDFAPYLDYCASLQNSDENEPDENEPDENEPDENEDGSSNSKPSSTSRPGETTFSGNEVIFGTPKLAPKPTTTLIPTPTSGPTGRDSPCYNDCSAALGTAIDIGQVSQLCIQNGDFSQKLNRCSGSCKNNNDALFLIGGLLNKMQPYASYCKWDVNIVLSPGTNDITNGGKNGAPNATATRLPEQQTQTAEPTSRSDSAGGGSKAWIAGAVLGPLLLVLLICGVVFLLLRKRKQKLQSWKNSIAERNSDSLSEKDGENCISEMPERDHPIELEGDSPTVGELGVNEQLDVPRQTGGGEKTTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTZ9</accession>
    <name>U4LTZ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_14295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTZ9"/>
    <dbReference type="STRING" id="1076935.U4LTZ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="401"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="775" mass="88072" checksum="CDC7E83E8EC39C9B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUZ0</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUZ0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10205" checksum="536D8B5BB3365918" modified="2013-12-11" version="1">METHLYPSLYFRKTYLIGLHSTWPETESKLLASFDSLTQSTRSAAVTQSLSQALAWVLISSVMINRPLPSVPPGSLGSLWFEQPRSDHRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV58</accession>
    <name>U4LV58_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV58"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="18850" checksum="E63A152A69C5B85A" modified="2013-12-11" version="1">MSPKRAEDGASGMSSKRAEEAAVEDEMIRRVHEAAEGCTEQFSNPSISTSATAQTAHQPVIWQPTHPTSDHVKHTGQANALQLARGPKKEEEGRGRGRGRKGRGRGRKEEHPTGPSRTELPLSSSSSSSSSSCHAAALSATSSPRCTEGVVGLASASASASAVASASAASSASAAAAACLFCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV67</accession>
    <name>U4LV67_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV67"/>
    <dbReference type="STRING" id="1076935.U4LV67"/>
    <dbReference type="OMA" id="WISVEIE"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="365"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="921" mass="100695" checksum="3632BE2F9219D88E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LY60</accession>
    <name>U4LY60_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Phosphoethanolamine N-methyltransferase 1 acc. no. Q9FR44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936628">
        <property type="protein sequence ID" value="CCX34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LY60"/>
    <dbReference type="STRING" id="1076935.U4LY60"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWLYSEN"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="318" mass="35670" checksum="02F56CD73F1239C5" modified="2013-12-11" version="1">MDTGSIDVDEACYSPGEYPSSDNSSTSSLDSLIIRHVFENGRRYHGFRKGRYLLPNDKIEQDRLDMQHHVYKTLFSALYTAPLSTINPKRILDLGTGTGRWAIDMAYEFPGAQVTGIDLSPIQPSWIPSNCTFEVDDVEATWTIAPRTIDYIHIRGLLGSINDWPALLAQAFSSMKPGGMVEITDIETYFEVEGDVAKEFGELMKEGMDNLGRTRIIPSELPAMLTNAGFTNLQERRGRIPIGIWPIMPNLKELGRLWRECLLAGLDAWGLATFSRGLDWSKAEYDVLASNLRREILERGSHRVSRAVSFVARKPVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU97</accession>
    <name>U4KU97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU97"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="7468" checksum="24B8EB14658B169A" modified="2013-12-11" version="1">MDTNANNIATKLDEVEGKVGKMEGKLNIIHDNILAAAKAASAATRGNPRELKLLVAKIEKCKESGSKNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUN9</accession>
    <name>U4KUN9_PYROM</name>
    <protein>
        <submittedName>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="266"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
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            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
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            <begin position="160"/>
            <end position="179"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX04466.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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                <person name="Kumar A."/>
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                <person name="Kumar A."/>
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            <dbReference type="SMART" id="SM01017"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCX05057.1"/>
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            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
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    <accession>U4KV89</accession>
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        <submittedName>
            <fullName evidence="5">Similar to Probable feruloyl esterase A acc. no. B8NIB8</fullName>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="290" mass="31351" checksum="50860A4A0363EE20" modified="2013-12-11" version="1">MKYATVFSVSLLSSVGAFPGPTHNKRSVNSTLFSEFTRAAKLAHCAYQPICVSPVGTTRLHTIYNIIFDTNGFVARDDTKKQIIVAMRGTSSLSDILVDLDNTLVPYTSTSSTECSGCMVHRGFQNQWNAVVADVIEKVGEQVKAHSDYTLLCTGHSLGGALTPFCAVSLEKNFPGKVTAISLASPRTGNPAWISFVEATIPSAKLFRLTNQNDTVPNDLTEAEGFKHHATEHWSPERPVTEGNMVVCNGGEDASCNKGHSKENAGFLGINEAHFHYMNVDFANSTAAEC</sequence>
</entry>
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    <accession>U4KVE2</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="169" mass="19378" checksum="AEE7A489F19FEF27" modified="2013-12-11" version="1">MVLINYELDLWRFIETFPVTIAYTIESDHTIDDVKTVSLPAYHGMWKLCVSYRQPLMTHPFSYFQSLVSASKPIPLKLPEGFFTKQPSAVIVTDRTITAHTREWFRKTTQSTTTSELYQKNQSLSMLLSPSPAFFRFEAIKGTCHSRTRHAPVAAVRHREMTACCLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVK1</accession>
    <name>U4KVK1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVK1"/>
    <dbReference type="OrthoDB" id="5419844at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="216" mass="24013" checksum="5F85CBD27180A769" modified="2013-12-11" version="1">MNLITYAKSLSLHNTIMPATLNNHNGLVKILSENRVIMQFVQYLHVADFLNLMIVSRPVRSAITRHSSPGASEMLSTQHVLVLLSRTRCKSSHKAPVRIGVRECVWCGDSICKGCDVAPYLPFSHRLRRLCEDCYAVNAVQKTKRGSKFCACHPGDKAVCPECPWQWQEESGLPGVNPGTLVQSCWVCERETGIAGCGWFCLWCERGLYGEATGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVR9</accession>
    <name>U4KVR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVR9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="5974" checksum="C43AC6D5B50AD854" modified="2013-12-11" version="1">MHTARSLMDPIPTVRYSEADDLDVATVACLRGPCGLPKLLRTFKCISASPRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW58</accession>
    <name>U4KW58_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_05490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935275">
        <property type="protein sequence ID" value="CCX05903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW58"/>
    <dbReference type="STRING" id="1076935.U4KW58"/>
    <dbReference type="eggNOG" id="ENOG502SHW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RISAPMI"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="213"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX05903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="376" mass="42686" checksum="16E559632585ADDF" modified="2013-12-11" version="1">MLPPSITICLMQFSLSVLSLLAAYHTPPTFYFLHVILQAFCFLLQFAYPPNSNAVLTYVPVAVSFFQILRFSDFLLLSRPYEEFHQPGKPKYADLRPLGRLKWALNTAFSTRGIGWSWEIPYLPSSSSPITRRSLLRSLSVTYMMYDIMHTYSMRDPYLRTEGKEGVRPSEMPFSKRAPLMWAAGLSAVFGIVAPYIVVCVLLIGVWGKAEDCRPMFGNPWECTSVRRFWGRGWHQLVRRPLQVHGRWLAHDILGFRKGGAASAFTQAVVVFTLCGAAHWIGCFAADRSRWWIRTQAFFMVQPLGMVIEGAVMVVGKRAGIRDVGWVRVVGFAWFAVWIGLTLPLYIEDCAQVGMLKEMWRLSFVQGVSAGKWFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWL0</accession>
    <name>U4KWL0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWL0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="172" mass="19922" checksum="A73078F102C274CC" modified="2013-12-11" version="1">MTTPFEISDLDLYLLYGSSTEVLPPARPADPRTVKKYYRDQRAIETRSKFSLYTSSARLSTSQQVQQQTAGYPSATYRPSPSIESYHHSDSQSSEKHQPRQRLSRIFGRLPGHSNDTVVSIRELNESGKLEDNLEGQDEQEQTQHRPSLRKRISQFFGRRYKKMDETQVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWN6</accession>
    <name>U4KWN6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_05924</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWN6"/>
    <dbReference type="STRING" id="1076935.U4KWN6"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11945" checksum="D6386758E2BC7E09" modified="2013-12-11" version="1">MVTTASRSAVRSLYRRALQTSLSWTVRRDAWRIQAMNIRELFEANKDVTEPRQLSKLLKETEDTLHKWRHPDAYVPPTAPGGSKYERNLPVPYTAPPPHFDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXE4</accession>
    <name>U4KXE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935314">
        <property type="protein sequence ID" value="CCX06802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXE4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10369" checksum="FDFBD13837D614B5" modified="2013-12-11" version="1">MWHEILDFLRLASCLYSPQSRFSGLEIELVPILEAPVSVDTRHLERRQSRKLSIPISGTMTNLDDLCTTILFNLIIAVFITPVSIKDRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYP7</accession>
    <name>U4KYP7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYP7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="8706" checksum="19499E07F49B1891" modified="2013-12-11" version="1">MDHDGARAGRGTVSQTVPQTVPQTVPTQLPTTADSQARYDSADAASSSPSGSGVWLAGESKKKFLDFAESSTNSGCRAPTAAECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ01</accession>
    <name>U4KZ01_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized oxidoreductase SACOL2488 acc. no. Q5HD73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935345">
        <property type="protein sequence ID" value="CCX07241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ01"/>
    <dbReference type="STRING" id="1076935.U4KZ01"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HDFMANE"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="17529" checksum="A173BCCA3A95192A" modified="2013-12-11" version="1">MHSHRSGTIAILSSIGAYSATPNCTLYCATKSVLSILSLGLSREVSSLGIKVISIEPGYFRTNFLAGGHRVQAQKRIGDYDGEARVRFDEVDGKQKGDVEKGAKVVVKMLTGTGRAEGKQMPKRLVLGSDCVGAAEGCLEEQRRELEEWREVSLSMDHEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZX8</accession>
    <name>U4KZX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized membrane protein YLR326W acc. no. Q06170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935403">
        <property type="protein sequence ID" value="CCX08249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZX8"/>
    <dbReference type="STRING" id="1076935.U4KZX8"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDAGYKC"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="284" mass="31363" checksum="E55868D1F456E29C" modified="2013-12-11" version="1">MTSLIGKLVFDKILKETLDNKQGREDPYFEYVPTKKLASFSGKPRMKKQKKALPPGLSEEDQEILVKVKRRAYRLDMALGTCCGFKIGWGSVIGLFPAVGDVIDMMLACLVVRTASQAKLPNSVLIRMLFNIALDFVVGLIPIIGDLADIAYKANTRNALLLEDHLRARGRRNLRKSGLPPQPDPSLGEVEIEEGIIYTQPVSHPQPSYGVVGSSGRGHRDDDRGYSGSRREYDPESQRGSRNDRGGSKHGRDERGGSSRKEGKGRGHQRLPSQETGTTAASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0I0</accession>
    <name>U4L0I0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Cell wall mannoprotein CIS3 acc. no. B5VL27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935364">
        <property type="protein sequence ID" value="CCX07703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0I0"/>
    <dbReference type="eggNOG" id="ENOG502QQD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CASGTFE"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651004" evidence="6">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="7">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="21527" checksum="E894F03FB5FEDC9E" modified="2013-12-11" version="1">MKFTVAAPVAICSLFLLFAPVRSSPPSPLPVPRVPESKQYDFYGRTPSLEPRDAVPEPVPQGMWDWTAPPGGLPGGCVNTVDFKFILQPSLTPPRAPVPVVCGAAGTMKSNLKAGRLTDNLGRIGSIVSNRQFQFDGPPAQAGAIYTAGWGVCDDGALALGPSKIFWRCLSGTFYNLYDQNIAPQCEIIYLQVQRVVDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L112</accession>
    <name>U4L112_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Lysine-specific demethylase 3B acc. no. Q7LBC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_08920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935457">
        <property type="protein sequence ID" value="CCX09327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L112"/>
    <dbReference type="STRING" id="1076935.U4L112"/>
    <dbReference type="eggNOG" id="KOG1356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCIERRN"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="467"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="726"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX09327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="940" mass="104655" checksum="23A5B61F0322F223" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1D3</accession>
    <name>U4L1D3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Transcription initiation factor IIB acc. no. Q58192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935487">
        <property type="protein sequence ID" value="CCX09677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1D3"/>
    <dbReference type="STRING" id="1076935.U4L1D3"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10345433at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="4">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX09677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="36922" checksum="6425C25F2F3AD7E1" modified="2013-12-11" version="1">MAPASTPGWKPIIGLTSTPDSSTPSSSATNSSANSPESSISPPSTPTKRSRRPLHALELAGLTPSDYKRLQDFQALLKPITSSLSPLIQSTTLNLLYKALSQRWFASVSYSVNKLQVACALIFEACKRCGEPHDMKEIARLVGLDSGQNFRKYVSLMNRKLVTLGAFEGTSAATMAWDLLPRYAERLGVPQVAKAAIGVAKAVGGEMVLGSRAANNVAASCLYVACILGGYPRGLRQLAEEAAEVTKGTIKKSVKLIHAKEKVLTANAFWPGDLNVAFWDMMIDPRYFHCTAKSLPKKKAEFIEESESEYEGNCNPNSSEKMKVCVGHAVDSPRYTENRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L316</accession>
    <name>U4L316_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L316"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="103" mass="12663" checksum="1ADA98D6CF63A167" modified="2013-12-11" version="1">MEYMEYMGFLWYIWCRLRLLQSINKELRKQQLFVDDCLLIFIPNRRKEEDYQLRRCIGLSIQTKEEFRGWAPFPTYFLRRIPESYSNVFKTSCQIWKSSSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L329</accession>
    <name>U4L329_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Replication factor A protein 2 acc. no. Q92373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L329"/>
    <dbReference type="STRING" id="1076935.U4L329"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000184">
        <property type="entry name" value="replication protein A 32 kDa subunit A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="9">
        <location>
            <begin position="165"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="270" mass="29205" checksum="36FFFEB5A57CCAC7" modified="2013-12-11" version="1">MSYGGDYNQGGGGGGGGFYAGSQGGTQASPGGSESRRNRSSETLRPVTIKQILEARQEVGDGPFMIDSVELGLLTFVGRVQGVTEQATNITYVLDDGTGTLDVKQWIDADSPSDESAQNLNDKYVRVLGQLKSFSNKRHVGAHRIRAVEDYNEVQYHFLETVAVHLRLTRGPPEQFTGGVGGVKQQDTEMGGMGNTSSTSRLPPGLSDNARKMFLQIKDVTENEGIHVNVVKMKSGVPDHLATDAITELLDLGVIFTTMDEWHFAPMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L351</accession>
    <name>U4L351_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Vesicle-associated membrane protein-associated protein C16G5.05c acc. no. O60119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935205">
        <property type="protein sequence ID" value="CCX04470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L351"/>
    <dbReference type="STRING" id="1076935.U4L351"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFKRPFN"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28953" checksum="A1F03FF525904757" modified="2013-12-11" version="1">MSVELDPSELSFQRPFTREVVQTLRIKNTNYDPVAFKVKTTAPKMYCVRPNSGRIEAGKEVEVQVLLQAMKADPPADFKCKDKFLVQSVAITADREATNVQSIWQAVEQTEKSAIKERKIRVIYLEADEDSSSAPAGNYDASPPPYASPSTPVDAQSIQSTNTRPISRDAASNMSPSVHSTRSIAEDKDAELTAARATIARLEAELKQQSLRLRKTAGAASDAKDKITEGAAAGMNMTAHPPEGIPVQICAALCLLAFFIAWFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3C6</accession>
    <name>U4L3C6_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935586">
        <property type="protein sequence ID" value="CCX11027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3C6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8895" checksum="EA3381BE857D6CB5" modified="2013-12-11" version="1">MAQLEWRIDDAAALSLARVITYYASIQLPKYNRNVDPDQRTSTQHELRKETPAVWQRWITGMGVEATPRHVRWMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Q3</accession>
    <name>U4L3Q3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to COP9 signalosome complex subunit 7a acc. no. Q7SGS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935214">
        <property type="protein sequence ID" value="CCX04685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Q3"/>
    <dbReference type="STRING" id="1076935.U4L3Q3"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="289" mass="31561" checksum="902F3497FDF89043" modified="2013-12-11" version="1">MADQKYITALQPFVLAAKTAEGDAAAELVLQATQAPGCFVFSELLECESIQALGATHPQHLELLKIFAYGSLTDYRSNSNLPPLDDRQLEKLKQLSLITIASRGTQDLTYASLLQSLELPSVRALEDLVISAIYAGLLEAKLDTAYQLVDISSTAGRDVAPAEIDDMLAKLNAWSQQCDDVLADIDGQMERVHREASQKRKDNEDYEKQISLVKATIYRSGDEKGLSKGKRVISEGAEDGRGGWGEDEDGMDLDDVSHFAEGPGSWGPNTGRRRNKGRFGSGLGNKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3S1</accession>
    <name>U4L3S1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935555">
        <property type="protein sequence ID" value="CCX10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3S1"/>
    <dbReference type="STRING" id="1076935.U4L3S1"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="18996" checksum="9B2D82DF621DD926" modified="2013-12-11" version="1">MTPISQPYLPSLKRLPGAAAKTAGSLIYPRLFTYELSGINWADTPRERGTLTILFSCGAALGLCVWTGVHLNVDPGASGGYKRSTIETVSRFLGKSMWALIALFAPDIVLTVALHQFLVAYEYQRAVNKFAEKKNAQSGEGPVVPTETPAANVKRVSTMDSHSEPQKKKKSKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L489</accession>
    <name>U4L489_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Homeobox protein PKNOX2 acc. no. Q96KN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_10704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TALE/TGIF homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L489"/>
    <dbReference type="STRING" id="1076935.U4L489"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000059">
        <property type="entry name" value="TGFB-induced factor homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    <sequence length="340" mass="38073" checksum="8B6F6C966FEE1087" modified="2013-12-11" version="1">MYMETSSWNLENRQTFEHIGTTMSSSQYDPRTTLPPLAQAVPEFYTTAPHERRSSSVPRKFADRASPSLRPIQRLSPRSSHSNPDVSTAPSEPMDVSYDAASYPFPGQLDSRRAGSVSHHPYARPAVPSSYLPPVSSLTSSRDSSLDMERDRPAQQLPLLYGGNPPSQSQSYQPFEEQRQTPPEYGSNHRYTGSTGSYQTPSPVAHYAPYPSYSQQQRPHTSYNPRPSGMGVNGGMSGMGMNGGLGSPFPGSGHAEDYDNRQVKRRRGNLPKNVTDLLRQWLNDHLNHPYPSEDEKQWLMTQTGLTIHQISNWFINARRRRLPTMNQDKVGGNRRPSAAQ</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="4">CBS 100304</strain>
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                <person name="Gabaldon T."/>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
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            <dbReference type="EMBL" id="CCX12282.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="46" mass="5500" checksum="B1B9BE33FA6E6DB1" modified="2013-12-11" version="1">MDNRATELSPIRQQRHCTLTNFSPFRPRLDTFFFSHCDVHQIGYCL</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <location>
            <begin position="19"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="113" mass="13458" checksum="4DD220C045BAD27B" modified="2013-12-11" version="1">MVHRKSDTKSAITSDAPECMICYEPLHEPRRRNHILACKHDQFCLPCLQRWLDNPETKKDPHCPVCRRKALSKRRQFFNRFRFKTSFRLKRMFLGAPEAAFLAARFSTKLITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L646</accession>
    <name>U4L646_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UPF0676 protein C1494.01 acc. no. Q7LL04</fullName>
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    <gene>
        <name evidence="4" type="ORF">PCON_12293</name>
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    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L646"/>
    <dbReference type="STRING" id="1076935.U4L646"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHRGYSG"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="330" mass="36883" checksum="09A9536A6C86ECCC" modified="2013-12-11" version="1">MPFDTAIPIINFAAFTADKEQDRRNIGSDLFNAFRTVGFCYIKNLPIPPALISQSFSLSRQFFSLPESSKLLAPHPDSGTHQRGYSAVGREKISLYPGAKTDTPVFECKESFDIGREGDSIQPNIWPPEDLVPGFRDGSMVLFKTMRAAAMMVMESLALGLGLEEGFFDDYHSSEQCCNQLRFLHYPDVPAERLSAGNVERIVEHTDKGTLTLLLQEDDGVAGLEVEINGEWTQVPVVPGAVLVNIGDLLQMWSNDALKSTRHRVPVPKQTVSGKWGTERYSIPYFVAVDRGKIVECLKTCHGTERPKKYEAVDAWDYIDSVMSKAYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6C6</accession>
    <name>U4L6C6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935732">
        <property type="protein sequence ID" value="CCX12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6C6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5625" checksum="98049A2365CCECA9" modified="2013-12-11" version="1">MCWCKIFGATTDSNRYASSTSDHLRCWRLFFVCPDHTRLAHPRPHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6D3</accession>
    <name>U4L6D3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6D3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="12312" checksum="62A6BCA1B6EBC881" modified="2013-12-11" version="1">MFLMSWPNYAHHLSNFGRRIRIAGHRNLVWHGAHQDNSFDKAVGLHHHRPLPPTGAEAPHPHRAQRRLQDAYMHRGAAVMRTRHRDNPTKNSVCYAPSCGIKRRGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7B0</accession>
    <name>U4L7B0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7B0"/>
    <dbReference type="STRING" id="1076935.U4L7B0"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AKTVACH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="170" mass="18915" checksum="1BFAEBEAF5FF7ADE" modified="2013-12-11" version="1">MDHHAHMHHGSEASPMDMGHGGMPSGGHRCQMSMLFTWNTQDLCLVFRWWHVSGPLSLIFSLLGVVVLCMGYEYVRSRARRYDASLDATMPSDLPTEDSTLLTPGLVRKKKSGKLVKGAFYGGQVFYSFFIMLLFMTYNGWVMIAVALGAMLGYLVWGDDEPSGKSVACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8A4</accession>
    <name>U4L8A4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935777">
        <property type="protein sequence ID" value="CCX13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8A4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="16" mass="1648" checksum="E4E0DB4AE4472E1D" modified="2013-12-11" version="1">MPSTSDSNVNSEGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8H9</accession>
    <name>U4L8H9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ankyrin-3 acc. no. Q12955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01199</name>
        <name evidence="4" type="ORF">PCON_04139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <strain evidence="5">CBS100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935222">
        <property type="protein sequence ID" value="CCX04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CCX14973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8H9"/>
    <dbReference type="STRING" id="1076935.U4L8H9"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGQANIC"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="251"/>
            <end position="283"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="216"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX14973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="652" mass="70824" checksum="93A239CE6343E29F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9C6</accession>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">PCON_01978</name>
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    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
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        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L24e/L24_sf"/>
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    <dbReference type="InterPro" id="IPR056366">
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
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        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX15597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="188" mass="22396" checksum="307AA9A3BD792F29" modified="2013-12-11" version="1">MRIYSCHFCSAPVYPSKGITFVRNDAKEFRFCRSKCHKNFKMKRNPRKLKWTKAFRKAAGKEMVVDTTLTFSARRHIPTRYSRDLVAKTLNAMQRVEEIRRRRERVFYRNRMSGNKERQRAADRKLVEENQHLLPPSQRTIPSGLQKETVDTDGMEVDEEMLSEEEEEKVAVKVPRKKQRTEQRMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9K0</accession>
    <name>U4L9K0_PYROM</name>
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        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized helicase C694.02 acc. no. Q9P7T8</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">PCON_01541</name>
    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
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        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR44533">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="767"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1230"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1697"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1707"/>
            <end position="1742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1770" mass="198932" checksum="4E597626DDA02A45" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAU1</accession>
    <name>U4LAU1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAU1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9306" checksum="09A4A7E3D7D983CB" modified="2013-12-11" version="1">MSKIPGGPQPSPPSTKFAARLSFITIFQELRKTQNPHRQDPATSPTKRPVISKLSPRLRGAGHGNPSPSRFLGSASPKAPHIKDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAW9</accession>
    <name>U4LAW9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Probable nucleoporin C890.06 acc. no. Q9URX8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LAW9"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWAPFQK"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="8">
        <location>
            <begin position="129"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="7">
        <location>
            <begin position="660"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1094"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX16276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1351" mass="151025" checksum="308DF4870F371564" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBM2</accession>
    <name>U4LBM2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBM2"/>
    <dbReference type="STRING" id="1076935.U4LBM2"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX16190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="353" mass="39804" checksum="90620D34EDA89156" modified="2013-12-11" version="1">MPLLVDKHRPRSLEALHYHEGLSQRLKALANSGDFPHLLIYGPSGAGKKTRIVATLKELYGPGAEKIRIDSRIFTTTSNRKIEFNIVSSNYHLEITPSDVGTYDRVVIQSLLKETAQTQQVDTSAKQRFKVVVINEAEHLSRDAQAALRRTMEKYSPNLRLILVANSTANIIPPIKSRTLLVRVSAPTEGEIEGILKYTAGLEGLEYREALGRRIAKDSGRNLRKALLMLEAVYAQNEIVKDDTPIPPPDYEALISQIADEVLAEHTPARIMQVRSKFYDLLTHCIPATVILKLLTFRLIEKCDDALKADVIKWSAFYEHRLHSGSKVIFHLEAFVAKFMRILEGYLMGMVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBX7</accession>
    <name>U4LBX7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_05680</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBX7"/>
    <dbReference type="STRING" id="1076935.U4LBX7"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWINAIR"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="429"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX29609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="741" mass="84396" checksum="A877A603E5194FB1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCA1</accession>
    <name>U4LCA1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein FAM116A acc. no. Q5F3L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCA1"/>
    <dbReference type="eggNOG" id="KOG2432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EANLEHW"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="39"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="642" mass="71914" checksum="80820D087967D2FE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCC5</accession>
    <name>U4LCC5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to UBP9-binding protein bun107 acc. no. Q09731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCC5"/>
    <dbReference type="STRING" id="1076935.U4LCC5"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
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    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="997" mass="108912" checksum="814C88D6D0DB047D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCJ0</accession>
    <name>U4LCJ0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCJ0"/>
    <dbReference type="STRING" id="1076935.U4LCJ0"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX29784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8490" checksum="684A4B8BAF1FBBB2" modified="2013-12-11" version="1">MIIPVRCFTCGKVIGDLWERYLKLLEENVAEGDAMDQLGCKRYCCRRMLMTHVDLIEKLLRYNPAERARANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDA9</accession>
    <name>U4LDA9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDA9"/>
    <dbReference type="OrthoDB" id="10486072at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="365" mass="41081" checksum="E17F4D84C1A2B3EC" modified="2013-12-11" version="1">MGASAPLTPPKAISDTLLHTTKTSSGISKPRNANYDRWKVLSLSRQSAAQRHLGIRPTIPYNISLPILPISPPKTPQKPASPAISTQLIKPTKALEDALTSSISLTSPVSSVSPIITRRTLHLPIRRPPPRPNPQPRHHQSFLSTADAQILPYELFPSPQAVEAKYIPSQRTLYSRLAIKAGLPIYVIAKPPGMFRHPVTRFYPEAPRDPAAWLRGMERMERMEAMEGMEGEEDGDDEVYYACQLDVTPFRATKLRKPGKELLSKEKRVQLQKMNLKGMMEHRQGEVEVRTFNGYAVCGGVPFCYRQTRECVSGVEMGVEELKVHLREAHGLKVGRVVDIEGEWEAQERMKAEMEMETETEERME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDX8</accession>
    <name>U4LDX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to 37S ribosomal protein MRP2, mitochondrial acc. no. P10663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDX8"/>
    <dbReference type="STRING" id="1076935.U4LDX8"/>
    <dbReference type="eggNOG" id="KOG1741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006477">
        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="13379" checksum="407EC351D50AFB24" modified="2013-12-11" version="1">MPPKHGSLFKKNPIASWVNARILKDHAKRVAFAENEERRQALRYISQNTQLPQLQRLKAQLELNAMHCHTRPTQIKNRCVMAGKGQGVFRDFRMARFQFRLNALAGNIPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEA3</accession>
    <name>U4LEA3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_09212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEA3"/>
    <dbReference type="STRING" id="1076935.U4LEA3"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005147635" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="9">
        <location>
            <begin position="245"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX09619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="498" mass="53880" checksum="8CBE5E6FBF21562E" modified="2013-12-11" version="1">MSSLLLLPRLLILSLLTNLAFSQQAQQPLVSSSLLLPTLNQQSLSSHAISFSTFASQSPSKDRAIGTEGHKLSLSYIRQKLGDTGYYDISEQNFNIAVSRGTASLDIGGKKYDGFTMTHSPSGKVSAAVVAVAGYGCDPTNYRELEKMEGTIALIKLGGCQFGEQVARAGAAGAKGVIIYGGMPINKDQERAITLTLAERKEIGPYVPVIGVDEKYGAKLLAAAKDKKIVNIDVQVKNQWIMTTNVIAETKGGAKDKVVAIGSHTDTVPGSPGINDNVSGAGAALEIALQLSKFSVNNAVRFLFFSGEENEMVGSDYYMASLDEKSRQNFALYLNVDIIASKNHGYFVYDGSSKKVPVPPGSRQVQDVFDKYFQSVGIKSLPIYTEEPRGDYKAFMTSNIPIGGIHSGADFPKSEEQVKIWGGQAGEPFDKNYHQPGDTIENIDLSVWLNHTKALGHAIATFSRDVSGVPKLKEGQKLPLRKLKIRGVENRHPQFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEC5</accession>
    <name>U4LEC5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEC5"/>
    <dbReference type="STRING" id="1076935.U4LEC5"/>
    <dbReference type="eggNOG" id="ENOG502S70K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVAHSGM"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="24779" checksum="64C480334F01CA46" modified="2013-12-11" version="1">MASQLPRLRRSALPFAGSILGAVALTTSTVYADEPAKKSIYDAPPALVTPPNSEPTHPTPTDRLAVHIGAARRFINTHYRLACNKLDDAFSEYLSYEHSVTRTVAGLAPPKESSEKVLPGAIYVAVATMAGAIVTRRRVLPIRVITPLLVGVGSAWYFIPQTARNVGDLMWEWERKVPGVAETHAGVRSGIENAWKASVETSEETRRKFDETVSCVRKSAEDLVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFA7</accession>
    <name>U4LFA7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935519">
        <property type="protein sequence ID" value="CCX10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFA7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5240" checksum="4AE98DBB88EA8C24" modified="2013-12-11" version="1">MLIDSSLAGPCLPNLSTVIYQLVLRQPTSYPCHVKTLANTMHIEEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFM2</accession>
    <name>U4LFM2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to 26S proteasome regulatory subunit rpn11 acc. no. P41878</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFM2"/>
    <dbReference type="STRING" id="1076935.U4LFM2"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX30693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="328" mass="36813" checksum="F222B2D240A1FE1B" modified="2013-12-11" version="1">MDHTFSRMMAQQMGGMGAPPGVDAPVIDNSETVYISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDYTVRVVDVFAMPQSGTGVSVEAVDSVFQQKMMEMLKQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLNSRAVAVVIDPIQSVKGKVVIDAFRLINPQSYVLGQEARQTTSNLGHLNKPSIQALIHGLNRHYYSILINYKKTHLEENMLMNLHKTVWTDSLTMKDFKHSGCDNQDRLQKMVALAEQYEKRVKEEGTLTKEQLKTRYVGKVDPKKHLEELGKIGIEENIVDALVEMVDKSASIAAEGRQVCRLEEIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFM6</accession>
    <name>U4LFM6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_13855</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFM6"/>
    <dbReference type="STRING" id="1076935.U4LFM6"/>
    <dbReference type="eggNOG" id="KOG2966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKHECDA"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="204"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="43205" checksum="D4850B79F945C0F8" modified="2013-12-11" version="1">MSTETAREKAKAGKEEAEADLGVRLSGNDFARSQSVTWHRKKDGTTPPYEYREIGGRDVQDNEGVAIPGKRGRLVATPSRLLKLLVPLRPMNSDPSSMSADEPLALLIHPHQPLSYLERLIQAEIAPIEAPGVTRPPDITFLAHDPTKLDSHPDHPKRKNELVRWSAATEVGDFVRDASKGQEFVIVIEGRGELSVRVPSFEDRTYFLRQKLRGVSVEIDRLSRLKQECDTLAHKSAQNLAVGGFACLTSWWAAVWYLTFHTSLGWDVMEPVTYLAGLTSIMLGYLWFLYHNREVSYRSVLHLTVSKRQIKLYAQKGFDLDHWQDLLDEGKSLRKEIRGVADQYDVDWDESKDRVGERVKKALDGKKDKKDDEDREDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFU7</accession>
    <name>U4LFU7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFU7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="50" mass="5730" checksum="77D5732885BD9751" modified="2013-12-11" version="1">MPFAVNEHKKARVAREPRDLSRHAACTPISPPPVFYRNLKPKPMNLCSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFX0</accession>
    <name>U4LFX0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_09186</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFX0"/>
    <dbReference type="STRING" id="1076935.U4LFX0"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="129"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="415" mass="46923" checksum="DD645AD0C1A00478" modified="2013-12-11" version="1">MSLSCTAKREWRKLPVPLSELHINTVLRCGQSFRWRKNGNEWSCALSARILTLQQTPTHLLYHAIPFSPPGHPTTEDLLRDYFQLNISLSDLYKKWAAADPHFQRISSSFGGIRMLRQDPWENLVSFICSSNNNISRISGMVQGLCTEWGAPLGSVDIPSPVDPEDGMPLEEKTVAYYDFPPPEKLCGDEVEGRLRKLGFGYRAGYIVETARMVNDKGLDWLVGLRERPYQEVKEELVKLKGVGPKVADCVALMSLDKKGAVPVDTHVLQIAQRDYGFGKTKNKTLTTKTYDAIGEHFRNLWGEEAGWAHSVLFTADLKSFSEQLVKTKTETTSVSVKKERVVVKNETGTGTGVEKETPGEVKEQTRTTKRVRVKVEVKKEVNEEVNDEVKEQMWDDDVNGVPSSLAERVKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG17</accession>
    <name>U4LG17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Probable cutinase Mb2006c acc. no. P63880</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG17"/>
    <dbReference type="STRING" id="1076935.U4LG17"/>
    <dbReference type="eggNOG" id="ENOG502S6TR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652261" evidence="3">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="19899" checksum="5EEB28BB51FDF946" modified="2013-12-11" version="1">MKFVALLSLVLAPLALASCPTTEVLFARGTFEPQGDGWIIGPFLHKDAAATLAESSFYNVVYPASPDFNTSTPVGTADMMRRITEQAKACPETEFVLTGYSQGVMVIHGVELSADLKQWVKAVVSFGDPCKWRAGYTWPIDSVNVWDKCVEDPVCTGGTGSILNHLSYMANTDEAVDFIRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGD5</accession>
    <name>U4LGD5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_08934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935458">
        <property type="protein sequence ID" value="CCX30597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGD5"/>
    <dbReference type="STRING" id="1076935.U4LGD5"/>
    <dbReference type="eggNOG" id="KOG0822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKYAWYE"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
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        <location>
            <begin position="39"/>
            <end position="304"/>
        </location>
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            <begin position="311"/>
            <end position="474"/>
        </location>
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        <location>
            <begin position="477"/>
            <end position="675"/>
        </location>
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        <location>
            <position position="444"/>
        </location>
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        </location>
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        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <location>
            <begin position="347"/>
            <end position="348"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
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            <position position="401"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
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            <begin position="428"/>
            <end position="429"/>
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        <ligand>
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        </source>
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            <dbReference type="Pfam" id="PF17286"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX30597.1"/>
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    </evidence>
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    <sequence length="676" mass="76087" checksum="9E85FCAE726B24DF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name evidence="8" type="ORF">PCON_01318</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="9">CBS 100304</strain>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="506"/>
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        </location>
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        <location>
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            <end position="385"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX15054.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="935" mass="104525" checksum="D73BC6DE8782F36D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGI4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_09834</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4048" checksum="3BEEAE22912F47E0" modified="2013-12-11" version="1">MYLDIDPRHSVSGGGFANACTDIGFTSCPSNDCARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGL6</accession>
    <name>U4LGL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C4D7.10c acc. no. O14174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
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    <dbReference type="OMA" id="HNYNEHI"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="155"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="970" mass="106246" checksum="3625CC5FE2B6F496" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHL4</accession>
    <name>U4LHL4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_02684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4966402at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8950" checksum="6E3E1AFE7222F427" modified="2013-12-11" version="1">MCSWERVEYRACGHIHKRLVGYCHFARNDPFRQCFGVQTTRRERAADATEQCPHCPTAQPQTQQPGHQMQDGQMMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIW4</accession>
    <name>U4LIW4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936498">
        <property type="protein sequence ID" value="CCX16674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIW4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="33" mass="3494" checksum="ABDF7B20884EF666" modified="2013-12-11" version="1">MCSGICRRFTAVPGTFQTAIEPVCAALSHCILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ30</accession>
    <name>U4LJ30_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ30"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="69" mass="7699" checksum="AD920186A0ECE6A5" modified="2013-12-11" version="1">MQPCTIHHALDSSTLDRMRHLSSLCALSFSSPSCGLFPKRSHWTEESPSSTRRSQNSGSGTQNIKIVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJU2</accession>
    <name>U4LJU2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJU2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="10652" checksum="D518900965B9D301" modified="2013-12-11" version="1">MVMSCTKFVEPPIPRYDESELSCPCALGTNSSICSPVCGESMDGAPGDDHKNHRLPKCKVHNMKTPPIIHPGRSISDLVSLPAWKQPSLPTSPDTDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJW9</accession>
    <name>U4LJW9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJW9"/>
    <dbReference type="OrthoDB" id="10514964at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="382" mass="41247" checksum="FEA20B36CD9038DA" modified="2013-12-11" version="1">MSAIHVGFGLQRLPPPNPTNKASPKPRPSPSPKPKPKNPTNPNTGGGLILPSSGDFPKSQPIKPAPNPPSSEGSKTNPVKSPGTLNGDNDKDIVKTNPIKPGDGKPGTSLENPASALPGALPGLNKVNVTQPYEGLFNDGDINFGTELPVQIFEGNITIINPVSTPLILSDSGYWNSVQLNQKYIPGILISVNIFFSLLESLVSETIALFGKSWRQEWSKFRKVEKHDMDIERAIKCGCADCSKVYAPIPKGFVAPWNKAWVVVKKRPRATKAPGRRGRPLHSDINAPMGAKRLSIPGSIIEEDEESMRAFNSALATSTANYADTIPDTVADMEMNIESLVHDPGLTLKRQKSKTPKWLEDATIGEIERVTGGAIKRESFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK48</accession>
    <name>U4LK48_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935776">
        <property type="protein sequence ID" value="CCX13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK48"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8269" checksum="C70BBF91AB5C1209" modified="2013-12-11" version="1">MHLKPAGLVTHSTARTPQQTATVAEPVRTTGCLSSTSTCVSSNPPSLHVFNSEHSESTPGLARKYLIVISHHHLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKB1</accession>
    <name>U4LKB1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_13389</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKB1"/>
    <dbReference type="STRING" id="1076935.U4LKB1"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 22" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 22" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 22" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCX32549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21352" checksum="44F1EE2472104F1D" modified="2013-12-11" version="1">MWIVNWFYDVLSSLGLMNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILQPTLHPTSEELAIGNVKFTTFDLGGHQQARRLWKDYFPEVSGIVFLVDAKDTDRLLEAKAELDALLSMEELSKVPFLILGNKIDHPLAIPEDEMRNVLGLYSTTGKGKVALEGIRPIEVFMCSVVMRQGYGEGFRWISQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKL7</accession>
    <name>U4LKL7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKL7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9373" checksum="C03843579F477EAB" modified="2013-12-11" version="1">MRYQAAVSPQLYDAMRVAHVSYLGLSSGQLQPSLRPHRLGCSPRHRYEYLLRGITPLSLSTATRRIGLQLDSWVLVCTYTVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKM3</accession>
    <name>U4LKM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKM3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14346" checksum="CB08D8D65B522623" modified="2013-12-11" version="1">MLGAGSLRGSPHGQQQHPVPYQNRLTFELLNLRHTSSLQTQFLRVVVKATGATGTTDFVPLFADWYVWAKRRTSTRKFWRSGEENLAEEVHEAGKVKKVHKTPSSVRKMKVRKNMKVGNELTRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKT1</accession>
    <name>U4LKT1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UPF0390 protein AFUA_1G03640 acc. no. Q4WK56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKT1"/>
    <dbReference type="STRING" id="1076935.U4LKT1"/>
    <dbReference type="OMA" id="MPQTALK"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10313" checksum="414D9744F75D0EB2" modified="2013-12-11" version="1">MPQTALKKSKPQALKPVKAKIDRKPGVMRKGLRNFAPKTKNAKMEEQKRKLSGQLAAGTEKRLAARAGHLELLAGGKKDRKEAEAAKKAEAAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL38</accession>
    <name>U4LL38_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized protein BH2278 acc. no. Q9KAK9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL38"/>
    <dbReference type="eggNOG" id="ENOG502S020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GNLIICE"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="271" mass="30290" checksum="AB6009B916F6B0D6" modified="2013-12-11" version="1">MSRHPDFKTLEASRPAFPEQKLVYSKTPNPDWKPCTPAPTNNHTHISLDPNDPARAPGENYKLLISAVVPRPVGFVSTVSPSGHRNLAPFSYFQVANHDPPIFTIGFAGENDKDSLRNLKETRECTINIISEDFIEAANYCSVDSPPEVSEWDLSGLTPAETEFVKAPRVKESVFAVECQLVHTHEWTSKRSGKKTGVLAIVEGVKFWVRDDAYKNGMLDLEVLKPVARMGGVTYAMTRGVWELPRPRYEEERKNPDVKAVEDKGKQNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL78</accession>
    <name>U4LL78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat domain-containing protein 50 acc. no. Q9ULJ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL78"/>
    <dbReference type="STRING" id="1076935.U4LL78"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="364" mass="41880" checksum="B420CB08D8A38F9E" modified="2013-12-11" version="1">MFSIIGSKQRQWNDPEEIARRLWLAEIQESVEEMYLRDTPVLLDYIYRVSLDPGLRQTPPIITVECRHLHQFAHWWLDYATGAIFGPYSVEAEDIITTSILEKSKDNPIFRALLAWPFEFSQYRFPSKEWNMFLWEGGNPIETVLKTEYSLLHIAAASGFEKVVRWCIEESGITDAYQFSNKDREGRTPLMLAANNGHTKIVEILLDVKMLFIYHGNLIDNEGMTALHHAAEWGHQEVVKVLLSWEKGLDVHWEDKARRTALMLATKNGHAGIVEVLMVCKGRYILVNAKDRQERTALSIAAELGHKEIVRVLLRGGASNWKDIDGRTPMSYAVRNGNFGIVKLLLDRACYRMMCVVKEEEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL91</accession>
    <name>U4LL91_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL91"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="6707" checksum="F6FBA90613AE9CA0" modified="2013-12-11" version="1">MYASHETTGAVYKQHKDHSIAPYFHLIPITTASKANLAAEKMCATECGGKYCKEAFSNGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLV7</accession>
    <name>U4LLV7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Zinc finger protein C25B8.19c acc. no. Q9UTA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_14165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCX33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLV7"/>
    <dbReference type="STRING" id="1076935.U4LLV7"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PAYPSAC"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="242" mass="26632" checksum="A786438FFA788955" modified="2013-12-11" version="1">MNLPSIVHSSPAPGHYHSMSPYPPQYTSTPAPPAPPPSPPVEDTKRLPSISTLLMYTEGSSQPAHSAPQERQQSQPPRLPPTPPMRPDSVFSAGSASPTISSSVPASYYYSAYNTAGNRSSYPPAQKPIYPSPTDGYPPQYYPQDVYGKPQMLVPLSVAPPSSSNPWHHHHHQSPTTHQAFPQSQDRYICQTCNKAFSRPSSLRIHSHSHTGEKPFKCPHHGCGKAFSVRSNMKRHERGCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLY4</accession>
    <name>U4LLY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLY4"/>
    <dbReference type="OrthoDB" id="10391363at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="248" mass="26390" checksum="5BFA0C97AF058951" modified="2013-12-11" version="1">MNPLLDYRVPTQYFFNLNSEDPNPESHAPPASGTYLNGSNNPYADHLLSSSSSSTASSTAIMSTSPTQTSPVNDDADYHAIAAGLGFEIPAAQIPETDVAFGTLSPRIHYVSTLGEQFLSDDESGVSEHTPVPLTSENLKAVTLALDKNKRAQEKEMELKAAVESALGGASVGTRQLAASKKSSMSVEGKFGAAVDKIIEKEAATQVTQQQGQASKPVAALESIVKKKRAKGLWNRTIKQLKKKEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM21</accession>
    <name>U4LM21_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_14169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936028">
        <property type="protein sequence ID" value="CCX14575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM21"/>
    <dbReference type="STRING" id="1076935.U4LM21"/>
    <dbReference type="eggNOG" id="ENOG502S77Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WCLSSPR"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX14575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="18189" checksum="AF1D78C4A535F46E" modified="2013-12-11" version="1">MDKTIVALKIGGTACLGILTGVHLNFSTQTLKAILSLGSPTQAQKAFSVALGLLRGSARPLELIATTSLATAWFLSPRTGKHPYLWFASAPVLISIALERLRLSGVEYGITSTQTLKALQGGGAGREIDEEVNGEVIRDGIDQYQHWVLIRGGIIGSGFLMSLVGLYGDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM68</accession>
    <name>U4LM68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM68"/>
    <dbReference type="OrthoDB" id="10386794at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652454" evidence="1">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="320" mass="35933" checksum="5FE16B1D72A7598C" modified="2013-12-11" version="1">MLRLNYFCLIALAISAQVTAMPCDDNEEPVLNPGAIFDKPPNPELAIHYPGESHDTNEEHDHTHPDVVYENLNPIDSEISGPSPGENPADYWEHDHINPGAIFFKPPNPELAIHYPGENNDKGEIIWERSLSNQDPGIEATIPTGSEDDDTMYLNGAAMYDEPLHPADKHLQEHPNDHSNVVSKGNPGFEFNEDILMKRVDAGNQGISKRGYNEYLYFYTHFKCWKNFHAPFKSVHMIAYYLQSKGKRWCCSGAKGECIVHARYQGTYAFWCSASQLPRCITCDKMGELLFRMANQCYKEGNLAGKATLGGIGDLTVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMW4</accession>
    <name>U4LMW4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMW4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="16258" checksum="D601BCDD12453196" modified="2013-12-11" version="1">MDTQYEGYPEDSDVEGLNFEATRRPYDIEGWDFIERLSQATKNGECEPEEEEEDSNEDRVPGREEMPIIVQPKPQLPPGLPPVPPYTPFEHPAPLHEHQLYLPLDFDYDNPGVPRFRPRPHPLKFFKVMFMDTIFDEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNF6</accession>
    <name>U4LNF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936022">
        <property type="protein sequence ID" value="CCX33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNF6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8441" checksum="D15B6561E41DE610" modified="2013-12-11" version="1">MYPSSLPSSCLYSTLCITHTLRKGTVMYFWARCNTFSSLNTRSDFTNIRRIQSLTSAVDIHHFHIVDLVLPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNL6</accession>
    <name>U4LNL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNL6"/>
    <dbReference type="OrthoDB" id="10603923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="301" mass="33963" checksum="3B9A325A4B0BABDE" modified="2013-12-11" version="1">MDTPDPPRLLADGMIPTMTSEEFQKMLENLRQGGATVPPCTPPNHRPQGAQGAQGIMSASPIPWWSPTPPPVHAVPNLPRSHTVFVTGSTAASPSPPPAYSPINSPRDSYVWPSIQSIAAGTPTPFSVDHTSCRRTLEQLKSQHSEQIDKMNKEIFQAQVDMWYARDEHAKTKDLLAAAKQERDSAPNGLEEEVMQLREQIRDLVRERDVARMEGVEMKEELSEVKGELEGVRMELGFVKAEKERLRDEVGKYEREKEMRELEEMVEKQLKIKKDKEEERRLQMVPGAFPASDIEVFRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNT6</accession>
    <name>U4LNT6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Probable importin subunit beta-4 acc. no. O60100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_09671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX30995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNT6"/>
    <dbReference type="STRING" id="1076935.U4LNT6"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANACGCV"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="393"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX30995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120223" checksum="938448443041800F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP61</accession>
    <name>U4LP61_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP61"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7317" checksum="31913854E53FEA8E" modified="2013-12-11" version="1">MASYTENTPLEVYMKRKQRLKELTDKAKREFVRVRTDVHGRARDVTSNHVEGVSGNDTRRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPB9</accession>
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        <submittedName>
            <fullName evidence="4">Similar to PH and SEC7 domain-containing protein C11E3.11c acc. no. O13690</fullName>
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        <name evidence="4" type="ORF">PCON_01856</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 100304</strain>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="825"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1340"/>
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        </location>
    </feature>
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            <end position="43"/>
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    </feature>
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            <end position="58"/>
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            <end position="82"/>
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        <location>
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            <end position="241"/>
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            <end position="266"/>
        </location>
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            <end position="322"/>
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            <end position="580"/>
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            <end position="613"/>
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    </feature>
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        <location>
            <begin position="1468"/>
            <end position="1483"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1513" mass="164712" checksum="07D1720DF8B4A6B5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPT7</accession>
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        <submittedName>
            <fullName evidence="8">Similar to Probable ATP-dependent RNA helicase DHX36 acc. no. Q9H2U1</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCON_10613</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004386">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
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        <location>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="5">
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            <begin position="1501"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPZ2</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">PCON_03211</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPZ2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="5924" checksum="3B9913DE7EB37042" modified="2013-12-11" version="1">MQSNEQQRYNRKADPVPSEVPSSAGVQQISDTAIGIVTVSILSCGVAVASSLFTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ76</accession>
    <name>U4LQ76_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Similar to peroxin-20 Pex20-Penicillium chrysogenum [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002562574</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LQ76"/>
    <dbReference type="eggNOG" id="ENOG502S3XI">
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    </dbReference>
    <dbReference type="OMA" id="DHHWDEM"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="285" mass="31936" checksum="02B995FAE8DEACA5" modified="2013-12-11" version="1">MAALCGPSNALQNLQKHTSADRSFQQDRFRAGGSSQQNFRTSTPQSGWVDNEFDAFSSGKLAPGLQSPQQLQQQFGSPQQFGSPQLQQQPAWAMDFQNLNIGQQPMMQQQHNQTPSWGLEFSQRMQLQPQQSYTSQQSSYAANNYTPQFSGLGMEMGGMGMQQEPLQRAQGAQEFQFDESAFEQAFAEAAREVNAGPSFDQTFTPFEPAFEHPTPIVQDKGKEPEKESFIKDQDDLARTAGQLLDSVKSDTSTKFQNSNFLALMRRLRDHEVVVEGDKMVETNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ99</accession>
    <name>U4LQ99_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936171">
        <property type="protein sequence ID" value="CCX33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ99"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10801" checksum="CF4F4E5E57465B20" modified="2013-12-11" version="1">MNQVQRRREIAARVLEENVISDVRTALQASGRGYGEVVPSLGAHVFPISRIRMQRCLVLYDIYNDRKKLGELMHTIGETEHETTNFPITMSIICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQG1</accession>
    <name>U4LQG1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQG1"/>
    <dbReference type="STRING" id="1076935.U4LQG1"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="498"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="673"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="893"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="992" mass="106809" checksum="ECCA69F18EED6D56" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQN8</accession>
    <name>U4LQN8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQN8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="112" mass="12504" checksum="E37E7C1222CA8FEF" modified="2013-12-11" version="1">MSPSVDMRLIGIMHGLTLIQMIHSSRREGLDGGAFCCFAAQDAQAAQVHIISGKHILHTLKQPSNLHTFRRSSTQSTSSPNTALIRYNCQLILEYRYIRSDTYSYVGVPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR85</accession>
    <name>U4LR85_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR85"/>
    <dbReference type="STRING" id="1076935.U4LR85"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISKWIDL"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15540" checksum="FA2ED0BA24F5D494" modified="2013-12-11" version="1">MPVNAIRLVSKSQNGVGAFVLQCKRLEFNYCDWAGSSKGMNSFLKNVLPKFAKENPQIEITVAPRPHRHPIIRGEYINGREKVICVANLEHNQILQKADLLRNSSGLKLKRFNKPVKSENQSVRGIYSPFHGANWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRQ2</accession>
    <name>U4LRQ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935395">
        <property type="protein sequence ID" value="CCX29971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRQ2"/>
    <dbReference type="eggNOG" id="ENOG502SAWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SMENILH"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="702" mass="76166" checksum="FFDEA6F5DA9B189F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRR6</accession>
    <name>U4LRR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Beta-1,3-glucan-binding protein acc. no. Q8N0N3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936586">
        <property type="protein sequence ID" value="CCX34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRR6"/>
    <dbReference type="STRING" id="1076935.U4LRR6"/>
    <dbReference type="eggNOG" id="ENOG502QRX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWSQTGR"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000178">
        <property type="entry name" value="Glycoside hydrolase family 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF62">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="139"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="466" mass="52599" checksum="435F064629E07AA9" modified="2013-12-11" version="1">MSTSQPTDVGESESVKDTRPSTPSMPATPRTADFSDPISPITERAPYALSSSVPGSTSGFSARFSSQPNLRVPGRYFHSRRVKKGTVSKPWLAKKDPREKWVTIIPCVGLLIGVGICAILVWMGLNSVVNHKYCPVLMEDWSNGFDESIWTREAEVGGYGNGQFEYTTKDEENSYVKDGALYIRPTLQDEKLITTNGATIDLRKMGICSSDQWYNCISTTNTTNGTIVNPVKSARLSTKKGAHITYGRVEVTAKLPAGLWLWPAIWMMPVNETYGPWPASGEIDIAESRGNPSNHPQGGNNIISSTLHWGPDPANNGWWRTNVKHKALHTTFADKYHTFGLEWSENYIFTYVNSRLQTVLFTNFNQRLWERGQFPLTNANGTRYIDPWARTGNRNTPFDHPFYLILNLAVGSTNGWFENGKQGKPWVDGSKTERKDFWDKRDEWYPTWKDNSEMIVKSVKMWQQCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSJ0</accession>
    <name>U4LSJ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSJ0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3654" checksum="8E4BFFEC508C79C5" modified="2013-12-11" version="1">MLMDHSGALQVLAQPCGVRQRNSSLKPGRTAPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSS9</accession>
    <name>U4LSS9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSS9"/>
    <dbReference type="STRING" id="1076935.U4LSS9"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="28772" checksum="5CF15D0AF611EDC8" modified="2013-12-11" version="1">MSYNSQLRSAILQFSRVTASNERTAIGYLKSSNWNVEAAANLYFSSNNGSRSRASSDKTELESLFEQFRDSSDQPNTMTTEGAIRFMEEIGVELDEATVLVIAELLQAPVIGVFEKDKFVEGWSSINAMNLETIRSKIPILRSNLDNDTDFKKVYKYTFNLALPPGQRSLPLEIAIYYWCLLLKDRFKDHIDDWISFLENKDRNSITRDTWNCMYEFVQLAKNDPGLASYDVDGAWPSILDDFVRHQRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTM6</accession>
    <name>U4LTM6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTM6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="69" mass="7357" checksum="CA368523F09D53E8" modified="2013-12-11" version="1">MELEKTHSYLTFGLELAIAADLLPPCREGAQMFIELLGRSNAESPGESDPPTPPPADHDVVNLGIEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUF1</accession>
    <name>U4LUF1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="11" type="ORF">PCON_01583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUF1"/>
    <dbReference type="STRING" id="1076935.U4LUF1"/>
    <dbReference type="eggNOG" id="KOG2314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="728" mass="83470" checksum="B638CEFE44FF159C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUM3</accession>
    <name>U4LUM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUM3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="258" mass="28711" checksum="24B22362A9157CC3" modified="2013-12-11" version="1">MLRTFFSPGIKPALKTGMPMHNIALIKPGTLGGLRHMPYYRKWLPRNPPTPPPIYFSEAAPYNYLLDAAVISLLVHSPEQFPPEYDPQKVYVNVTGVTSYWCLPHSRGFPSDHPITDALESEALKPFKPLGVQPPPRPIIAAVKELGLQLVTGAEYFFDKTYLEINKPEHPASEIARIVGLASASGVSSMHRVQALEDLAKDATEWRILEDAADRGMVFLTNEDFGRRWGGIIKAMKANGQYRGLRFEVVAGVKGMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV80</accession>
    <name>U4LV80_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized transcriptional regulatory protein C530.05 acc. no. O59741</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV80"/>
    <dbReference type="STRING" id="1076935.U4LV80"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDDNKWM"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="872" mass="96474" checksum="E0BBCDB7174C1CF6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVD2</accession>
    <name>U4LVD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to N-terminal acetyltransferase B complex subunit arm1 acc. no. Q9Y809</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVD2"/>
    <dbReference type="STRING" id="1076935.U4LVD2"/>
    <dbReference type="eggNOG" id="KOG2053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKRREHQ"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="928" mass="102424" checksum="67B0539B9BA56ADE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVX8</accession>
    <name>U4LVX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVX8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="153" mass="17511" checksum="745CBBB3E5DEFDE4" modified="2013-12-11" version="1">MTFCSCGFSAAMPVKEGLFPSTPMKKNVAFPIEFLDLRPEGGEGDTWRVLGTELKWKHEEFWKNYPKVSDGLAVLVKNAWDTWINVKHDVERRRAEKLRIPADQGIVNTGRHGMDGGDVIGISNRQKIMVLLQEVLFWYSQPQFRSFLHNSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWP8</accession>
    <name>U4LWP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWP8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="10955" checksum="A7F72B4C4E688239" modified="2013-12-11" version="1">MSASSNSTPTPANIQPSKQKPLQPVEPIPLSELELRYLEQSSRELERGLAFRCNIDTRSLPAMPKRNSAPASVPLGRYLAETDKEEHWTRPVAGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LY74</accession>
    <name>U4LY74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LY74"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11245" checksum="648BBD5175CDC2C1" modified="2013-12-11" version="1">MVNTHPSPYDHGMMGIGVQLPTNLLLKERSDDISSLLSLNHSLVTSGSDRNSSLATESTLTPEKERKIISKRSRIQSALLKLGARMFGCMRGRKKSTGAMEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTS4</accession>
    <name>U4KTS4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTS4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8669" checksum="DB15AC0DED693A6B" modified="2013-12-11" version="1">MIITRCLFRPSKFIEIGRTINILHIMYSTDKFPVSMGSQDQDSPDPLKDPISAADRSPKPKVRIQLSFWNLCNSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTW7</accession>
    <name>U4KTW7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein sfi1 acc. no. O13652</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935207">
        <property type="protein sequence ID" value="CCX04518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTW7"/>
    <dbReference type="STRING" id="1076935.U4KTW7"/>
    <dbReference type="eggNOG" id="KOG4775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WDRATVR"/>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="3">
        <location>
            <begin position="246"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="607"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="922" mass="109554" checksum="9B03338C887D3346" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUR1</accession>
    <name>U4KUR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to D-amino-acid oxidase acc. no. Q99042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUR1"/>
    <dbReference type="STRING" id="1076935.U4KUR1"/>
    <dbReference type="eggNOG" id="ENOG502T2FY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="146" mass="15348" checksum="ED6E455D05058649" modified="2013-12-11" version="1">MGAEKKNTKPHIAVVGAGVIGLETSLQLLTLGHPVTIVAAHFPGSTSIDYASPSAGAHWRTQSDDLFIRHCDAITYLSWLSLFSPSPSSTHAEITAALSTPAALAVTAETGIFVTYSLNVNRSALQSSAGRSAPWVKFTPSQASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUT2</accession>
    <name>U4KUT2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUT2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="234" mass="26405" checksum="78BC5492360F2173" modified="2013-12-11" version="1">MSSAESIASEAIENFISAEQWNNMPSEEPMTPPTCHEGYGEALSNRLDNPVPIMYQPTLPKNGDSLSDILNKYPAPIEFQQYLESIDDRSHIIGLFMNVVYGPVVDLRHCVYCHQTYNEAYNHGCKIPHLGILESIPSPGGELINSTNQWTCCLRLASIKHFAGAYCYEGRHHDRWLKFNCHCVAIHEGKSLGWWNFVGNRLKEDAECMETTVCKMNECMQKTSGVGMGRLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV08</accession>
    <name>U4KV08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ribosome-associated complex subunit SSZ1 acc. no. P38788</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV08"/>
    <dbReference type="STRING" id="1076935.U4KV08"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAHNTIT"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="552" mass="59305" checksum="2F0D1542A6087DD5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV23</accession>
    <name>U4KV23_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV23"/>
    <dbReference type="STRING" id="1076935.U4KV23"/>
    <dbReference type="eggNOG" id="ENOG502RY8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAERAHT"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23867">
        <property type="entry name" value="Mmc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="2">
        <location>
            <begin position="262"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="482" mass="53312" checksum="BD92A05E5B795C49" modified="2013-12-11" version="1">MFPPLFLRRTLAALSAVEHGIPESRIELALRGIEQKDAPVRIAVVGEEILPVLLGGDEGWTAEIKDWVHQYSKPGRGVLLRWGATHKATTPTGSPLTILIAPIELLKTNNMELVVMSRISRDPLVPVFNASEIKGARVIEYPVHKTLVYGGSGAEGVARVMETVTPTEDKPEQILRLVSLPGEPVKKECFHIIDVEAGKGIEAVKSWLVAGTTTEGSIKPVVKTLLHDILSAANKEISVSTPAAGNTGATRIEGGDSPDSLAAAISTWSHTAHLELKSSVAESQEWRKLDWWKLLWRVDDVGHISRHAVTTSFLRHSEADSTFLAGRLYGAGYRDRSSLEPELELERPYYIAEQRNHIVTALIPGLQAAAQKYLLSSLSTSGLSAVFSTLLYLSDIPLYSAMTVAAVGTVGSARWLQSRWMKERRGFQENMREKGREAIVESERWAWNRLKEGIATETEEVDAEREKRLRLREELEEGIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV77</accession>
    <name>U4KV77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="8" mass="850" checksum="FE35A6D045A1ADD6" modified="2013-12-11" version="1">MATSIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVD0</accession>
    <name>U4KVD0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to DNA-damage-repair/toleration protein DRT111, chloroplastic acc. no. P42698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVD0"/>
    <dbReference type="STRING" id="1076935.U4KVD0"/>
    <dbReference type="eggNOG" id="KOG1996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPMSEVI"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="355"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="55844" checksum="5898CB01FC36BC76" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVG1</accession>
    <name>U4KVG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Trans-aconitate 2-methyltransferase acc. no. C5CSI6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935219">
        <property type="protein sequence ID" value="CCX04891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVG1"/>
    <dbReference type="STRING" id="1076935.U4KVG1"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAMEIAE"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="322" mass="36479" checksum="A882526E31127487" modified="2013-12-11" version="1">MIEVDPSVLAKPENEDYASSGYDTSTASLTSSLNEYVVENGRRYHSYYGTEKYLMPTDEKEQDRLDLHHEIFRLVWSDKLHSAPLAEPHRILDVGTGTGIWAMEIAEQYPMAEVVGTDISPIQPCWVPPNCRFEIDDAMQEWTFKDDNFDFIHARNISSGVSDWGHLISEMKRCTAPGGYVELCEKSLVIQCDDGTMKPDHGIKVFTEYLRDAMRKMGRPCPDLAFLKNLLETAGFEEVTTSQAKEPVGPWPKDPRLKRAGAMNLLNAETGFESYGMALFTRILGMDVDKARKICEKGLMDTRNKNYHVYDTGLRVYGKKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVI6</accession>
    <name>U4KVI6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Ubiquinone/menaquinone biosynthesis methyltransferase ubiE acc. no. Q3A209</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVI6"/>
    <dbReference type="STRING" id="1076935.U4KVI6"/>
    <dbReference type="OMA" id="ENTEADY"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18697" checksum="3ABA704DDC24A6D5" modified="2013-12-11" version="1">MQMHQSTTTTAITTTENTEADYGNISPIEVEPEDSYHSDASSSYGSYIQSIVSYSFSINEYRIEHGRKYHTYFGDEKYLMPIDETEQERLDLHHEVFFDLLHGKHHLAPLENPERILDIGTGTGIWAMDVAVDYPEAEVIGIDLSPIPHSGRYVNLVIPCIGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVR6</accession>
    <name>U4KVR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVR6"/>
    <dbReference type="OrthoDB" id="10654751at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650781" evidence="2">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="260" mass="30872" checksum="740EAD0BF57B13E6" modified="2013-12-11" version="1">MKFTLASVVALFAIQAVAIAAPAPEAAAVADGYDNSYKQHDKYKTVTTTEYKYKTVYSTVYKKKPYYVTSTVYNVKTEYKKVPYPVTQTEYKYKTIYKKQPYPVTQTEVKYKTVYKEKPYPVYTTIYKKKPYYVTATQTEYKYKTEYKYKTEYKTATATEYKWKVKTEVDYKYKTEIKTEWKYKTETVKVPYPTTVTATVTEYKKCDYKKDDSHKKDDSHKKDDSHKKDDSHKKEDSDKKEDSDKKDDSYKPVEEHKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW01</accession>
    <name>U4KW01_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_05425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW01"/>
    <dbReference type="STRING" id="1076935.U4KW01"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTIFVAM"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
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            <end position="128"/>
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            <end position="177"/>
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            <end position="205"/>
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            <end position="317"/>
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            <end position="374"/>
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            <end position="414"/>
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            <end position="480"/>
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            <end position="514"/>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        </source>
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    <dbReference type="Proteomes" id="UP000018144">
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            <begin position="185"/>
            <end position="263"/>
        </location>
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        <location>
            <begin position="1"/>
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            <end position="91"/>
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            <end position="200"/>
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<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
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        <property type="entry name" value="PNK3P"/>
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        <property type="entry name" value="Polynucleotide_phosphatase"/>
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            <dbReference type="EMBL" id="CCX05942.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    <sequence length="465" mass="52286" checksum="515700D52542BD17" modified="2013-12-11" version="1">MPPKRALETTTTRSVSPPSKKATKASTIETTETTVAVKKTTTKTVEEKTTQGSPKKRIKSTTTKSAVASFFTATSKKPPVEKSPTSWNVVEETLLVGKYTRAGEEGNRGERRKIAGFDLDGTLIATQSGNKFAKNDADWKWWRECVPSKLKELHEEGYQIIIFTNQGGIKAPKKNHANLPKFKSKVAAVLNALDIPLTVYAATEKDRFRKPRTGMWQEMIDDYNLDVHGVDLENSYLVGDAAGRKGDFADSDRHWALNVGIKFHTPEEFFLGEAAQEMSHRFDPENYIADKESGGDKLLFAPKAEKELVMFVGPPAAGKSTFFRKNLEPLGYERVNQDTLKTKEKCVKVARELLSQGKNVVIDNTNPEASTRLIWVTLAKEYGYKLRCLYFNSPIELCHHNDAVRAFGGDTFNPDKRTLLPGIAFNTFTGRFAKPSKDEGFDVEEITFEFNGTEEERKIWSKYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWW8</accession>
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        <submittedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935272">
        <property type="protein sequence ID" value="CCX05746.1"/>
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    <dbReference type="STRING" id="1076935.U4KWW8"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
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    </dbReference>
    <dbReference type="OMA" id="WNDPFCT"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650822" evidence="2">
        <location>
            <begin position="30"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="902"/>
        </location>
    </feature>
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        <location>
            <begin position="668"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="794"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="902" mass="99299" checksum="0087A524D7FC8B12" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4KXF1</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX06812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4781" checksum="4C1BCE54946B142C" modified="2013-12-11" version="1">MTEIRQSRRRMAYVRRRSDDIILSHHMYMLLKTLGVRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXK7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX06235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="146" mass="16922" checksum="25C60C4D8D9816F5" modified="2013-12-11" version="1">MATTQPKGTWWIMLTPRDDTKDKIDKALVQQWFSSIDGFNIYNLAENRLNGKWLIDGGPYERCLATLGALHNDYEILCQKKFRFVYIAYSEGKDSDQDIVVGDFWKKRRRLTLNRDGVLLSAVLNNDATTGPVMPIKVQRKWLPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXN4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX06270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX06270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2348" checksum="65E467831A83D2C6" modified="2013-12-11" version="1">MSSMWSTSCSSTGQICLSIAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXU4</accession>
    <name>U4KXU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ankyrin repeat-containing protein, putative [Penicillium marneffei ATCC 18224] acc. no. XP_002144344</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_01951</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
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        </source>
    </reference>
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        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="158" mass="18109" checksum="8860B8BF9C9DBD97" modified="2013-12-11" version="1">MQFLKKVLKQFERSFVCIDALDECKDETGRDLLKSLKILADELSFDGHSVRIFITGRNHIESLITRYLMEEAGNTFTTIHLEVNSSDIEKYVHGIENDVKDVPMDIDFKEKLVSKIVSSSGGIFLLPALQIQTVLEYTIVREREEALEINARRAPKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXW5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935310">
        <property type="protein sequence ID" value="CCX06766.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5567" checksum="7F7815802378E64F" modified="2013-12-11" version="1">MRKLSNGIKSTGDVSFPAEFFGPFGALEDKRFYALLGPHFSRYRASIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY63</accession>
    <name>U4KY63_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
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        <property type="protein sequence ID" value="CCX04524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY63"/>
    <dbReference type="STRING" id="1076935.U4KY63"/>
    <dbReference type="eggNOG" id="KOG4593">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="747" mass="85471" checksum="07C1999DDBBFAE19" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYA9</accession>
    <name>U4KYA9_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_06548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYA9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="18237" checksum="9796A6EAC2773F47" modified="2013-12-11" version="1">MTSPRVSRSKLRGIRPPWASRRPPRLTTAPPMESKPPHGKPLETIALINNTTITTERVSPPAPVTPDAVAITVKPTSGTSGTSEDERLTRTEREYQEVLSALQDLKREMKLEREAMRAERRRSRSRGRQLERKVREDQQAERGGSRDTVETVRWWLGDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYU6</accession>
    <name>U4KYU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="6492" checksum="D49D9F35AB41F93B" modified="2013-12-11" version="1">MYQLVSTFFQMIPPLFSNFQIFKIWFSLLGVTWFLFYGCFFLGILEYFNLFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ82</accession>
    <name>U4KZ82_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to 26S proteasome non-ATPase regulatory subunit 12 acc. no. Q5RBI3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ82"/>
    <dbReference type="STRING" id="1076935.U4KZ82"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="248"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="475" mass="55144" checksum="D46EF89F06C5470F" modified="2013-12-11" version="1">MAETGAEREVLKAEKDYTEELDKELPQIISIAKNDNLNKAIEKLMVLEKKTRQASDLPSTSRILETIITLCHEAKEWALMNENILILSKKHGQLKLAITKMVRLAIKYMYEAPGEPNFDVRLSIIEALRTVTEGKIFVEVERARVTRELSKIKKQQGHLAEAKTVLCELQVETFGSMDRKEKTDIILEQVGLCIEQGDFAQALILSRKISTKWFDADISKKDPEIMELKLRFYEQQVHLSKQDSKYLDTCKYYRAILDTPRIQENPEELQKTLERIVYYVILAPYDNEQSDLLHRIRTDTRIQKLIPEQAELLRLFTVIELMPWARVSQRFETLLRATEVFGVDDPKGPARWEDLRKRVIEHNVRVVAKYYTRITMDRLKMLLDLDEDETETYLSKLVCEKTVNAKIDRPARIITFGTSRDADDVLNEWSGNMKSLLGLLERIDHLITKEEMMANIAPKVKSKEVKGKGRRPQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L029</accession>
    <name>U4L029_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07453</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L029"/>
    <dbReference type="STRING" id="1076935.U4L029"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QMGMDHL"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="284"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX07864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="407" mass="42956" checksum="C18230B3F88C25C8" modified="2013-12-11" version="1">MSILKRGLANILQKNASDVVFVSALRTPVTRAKKGGFKDAYPEELLAHVLRSTLDKTKIDPTKIDDVTIGVVLSELGGAKAGRMAQLHAGFPYTTTFNTVNRQCSSGLQAIANVAAHINTGMINVGIGGGVESMTRNYGSRAIPVDLSPDLKASPNQDALDCIMPMGITSENVAERYGVTREDQDHFAAKSHQKASAAQKAGLFDQEIVAMETRWIDAETGAESRKVVNADDGIRHNASYENMAKLKPAFKETGSSTAGNSSQVSDGAAAALMMRRDVAESLGLKPIGKYVATAVAGVKPDEMGIGPALAIPRVLEMAGITTADVGIWELNEAFASQAIYCQRVLGLQEERVNPKGGAIALGHPLGATGARQLATLLPELERQGEKMGVISMCIGTGSGLASIIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0N0</accession>
    <name>U4L0N0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Structural maintenance of chromosomes protein 6 acc. no. P53692</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_07347</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935374">
        <property type="protein sequence ID" value="CCX07758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0N0"/>
    <dbReference type="STRING" id="1076935.U4L0N0"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MCHDHFY"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="83"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="15">
        <location>
            <begin position="536"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="264"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="695"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="861"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX07758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127814" checksum="84C06BB17F3C6DF8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L392</accession>
    <name>U4L392_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L392"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3636" checksum="377A6B34064E0A11" modified="2013-12-11" version="1">MSLELPFLKMMLKNLYHWTDRYPCSFNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L475</accession>
    <name>U4L475_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Major facilitator superfamily domain-containing protein 7 acc. no. Q503P5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L475"/>
    <dbReference type="STRING" id="1076935.U4L475"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="STICWTG"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="474" mass="51794" checksum="0B9DCDAFB040B3C1" modified="2013-12-11" version="1">MRPHIPLPAKLRPSLTSPSSIEAMPYPSPSRDIKELDDRQDALLSIPSSSSGYGTTQQYKVYKRRWLGIIMLIVMNIVVSWGWLTYAPVSNLSKEWFSLESETPINWLSTIIFFSYVVATPAVVYGLHHYSLKPTLLLASFLLLAGNWIRYGGTKTQSFPVVMLGQILIGFSQPFVLSAPPHYSDLWFTPNGRVSATAVVSLANPVGAALAQFLGPMLATTAEDIPFMVLVVSIIATVSVFGWLLFPSSPPTPPSASGSQRKASVAETKKVLENNRNFWLMLVLFSIYLGLFNAFTSLLNQIMFPRGYSPDQAGICGAILILSGLISTAVVSPVIDRTHAYFLAMRFFVPMIGAAYVAFIWAPEGGRILAPYIVGALLGAASFCLMPLALELSVEFTYPVAPEWSSSALWCGGQLMGAVLLLVMDRMKDEKGDMRTALIFQGVLAAAAVPGVFLFRKEGGLRRLEEDKRMGGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4A6</accession>
    <name>U4L4A6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935595">
        <property type="protein sequence ID" value="CCX11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4A6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="28" mass="3005" checksum="5AE20261AA29367D" modified="2013-12-11" version="1">MDDQSEPGGLQSERGETLALTTSRAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L575</accession>
    <name>U4L575_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L575"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13862" checksum="2117C358EF31A6A7" modified="2013-12-11" version="1">MTYENVITLHLHLTLHYFSLPCDIGLRVKNRCPYQDYVTGQGDQPAGKDPTTLVSSNGQSRQILLRISQNLQFSLVVVGYHVASTELDGPTCIDSRQIHSFFDFAMPMADSKKQIKHRFSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5I2</accession>
    <name>U4L5I2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Tryptophan dimethylallyltransferase 2 acc. no. Q6X2E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5I2"/>
    <dbReference type="eggNOG" id="ENOG502S2XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MHWKSHL"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="413" mass="46756" checksum="2369C9E2DF7E0AF9" modified="2013-12-11" version="1">MTIPIASSTQDTEYHSRLSLFRRNNKVLEKLLKVLDLSDKDRKFWWTVSSGILAVLLEKCSYDDNLQLKFLRLFHQILPAFGPRPNEQGDCIRWSPLTLDSSPIDFSWNYDGSNSIVRLAIDNYASPDDPFAQKATKTLLHSLPGMDFELFNVISEEVWIKPGSEAETRVLEQYSKSSYAGRPCHILSALDFLKDGSVTAKVYVTARTAACAKGTTVARLVSNLIQMLDAKIFQATPLMPAYQVIDAYNEGLPKSEKQSVCLISWDCVKPLQSRVKLYLSSRKTSLKVIRDMWTQRGRLTGPVIDKGLECIDELWPLLYCPPEGYRGEDELKNRDGRSQAVLMNLELKPGKSLPAPKLYIQPSYFCGNDMDVAKSLARWFDSKGWSLGKTYVDDLKYALSVFLQPMHNLRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5M9</accession>
    <name>U4L5M9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935364">
        <property type="protein sequence ID" value="CCX07721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5M9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8618" checksum="7109C3E5AFEB86EC" modified="2013-12-11" version="1">MMPFVFVFFGGSGPLFGSRNESLNSGWWRCRRLLVTKLPEWISWPDDIVSLSGPHHLFLYFTGQRVSSVVGVCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6K5</accession>
    <name>U4L6K5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to GTP-binding protein rhb1 acc. no. O94363</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_11704</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6K5"/>
    <dbReference type="STRING" id="1076935.U4L6K5"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="187" mass="20849" checksum="C0DAA6A7FD208780" modified="2013-12-11" version="1">MPAAHPKQRKIAIVGSRAVGKSSLTVQFVETRFVESYYPTIENTFSRTIKLKGQEYATEIIDTAGQDEYSILNSRHSIGIHGYMLVYSVANKQSFEMVKIIRDKVLNHLGADWVPIVVVGNKSDLHIQRQVTAEEGKALTTEWNCAWTEASARHNENVVKAFELMIAEVEKAQNPAQPTGGSKCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7B8</accession>
    <name>U4L7B8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935275">
        <property type="protein sequence ID" value="CCX05900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7B8"/>
    <dbReference type="STRING" id="1076935.U4L7B8"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="259" mass="29068" checksum="DD5CFB10FDFEA331" modified="2013-12-11" version="1">MTALIATSRTATFTNRLKGVGQYKQRAVLAIVTFFAPDIMVSIALHQLLVALQYRRFANNYRSDLYSKDEENSTITYIELRMAFFALMGVFSVELMAIGVSLQWETIEIQTHCRYEIIQKVLQYPLNAVPAGPPLEKIIAIFQAGAILLECLGRKLQNLHITILEIHTVIHVILAIVMYWIWKEKPFESTDPIAIDQLETHGDISVMAQYIESLLEVVDLAERQLAPCILELSPLVTTNTLPHDKTFNLPAALGAIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7N6</accession>
    <name>U4L7N6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7N6"/>
    <dbReference type="STRING" id="1076935.U4L7N6"/>
    <dbReference type="eggNOG" id="ENOG502SRND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNTGWND"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651986" evidence="2">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="262" mass="29147" checksum="42BC83AC95E98766" modified="2013-12-11" version="1">MKLSIPTLLGLLSLVSASDPTIPGSLFSSDPASAAKQSAPFWFFGRSLSREPCYPESAVTSSGGPNPGTAVSTSPGAGCPSPGPWTGTYSPGNSFPTYYMVRYCSGDDSWRISYNLYFSHDGMTPIGHRHDWEWVAAIWKKCDGSSDTWCRNRLVRSFHTTTQNNDWGAIQNTINDKGEIRNLGDKNKRHPLIYVGAFKHAMFDTRKTTYNVIGLDEMEFRSNDWWYFAQDNLVPGTVIDRSWNFGDATSSPPVVWDSICSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L855</accession>
    <name>U4L855_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L855"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="14729" checksum="A401E5BE56353DAF" modified="2013-12-11" version="1">MSAPNNNDNNDHNDNPNLVTTFSHSTPYVSQKKERVAPYEESITTLDDAPGNLPPKAHSQGTMNHAPPSSSHSSKDENKTRKHDEAATVRSMTRSGSIGGLGNAGHEDQSRTTEQTRRAQGYGGERSGRESSDLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L940</accession>
    <name>U4L940_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Demethylmenaquinone methyltransferase acc. no. Q9RRT0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936044">
        <property type="protein sequence ID" value="CCX14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L940"/>
    <dbReference type="STRING" id="1076935.U4L940"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWILMIT"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37761" checksum="E1E5B77B3ADD84B6" modified="2013-12-11" version="1">MASSSAKTTAADIEVDPAVLADLEVDSYDSSGFATSTQSLTSSINSYVFENGRRYHAYYGTEKNHLPTDEKEQDRMDMHHEIMLQLLEGKLHLAPIGNSPQRILDIGTGTGIWAVDCADTYPSAEVIGTDLSPIQPSWVPPNLKFEVDDMSEIWGYKDDSFDFIHVRNLSQSVEDWDHLLRQIYRCTKPGGYFELAECEFTIKSDDGTAGPDFQKYMKLLTEACVKLNRPTVTADMAKDLLDRGGFEDVKVVTLKQPFGPWAKDERMKKIGAMVMLTADAGAEGYGLAMFTRVLGMTAEDSLALCQKTSAEIRNKNYHVWEPFHVAYGRKPLKASEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L943</accession>
    <name>U4L943_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L943"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7289" checksum="7CEE23B5CA817EA8" modified="2013-12-11" version="1">MYKRTRRSQCSYSRILHPISPSDQHGTVPASVRTPLRHARCTLQLTPCKKFLSSGETGGRIMSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L954</accession>
    <name>U4L954_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_01833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936188">
        <property type="protein sequence ID" value="CCX15505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L954"/>
    <dbReference type="STRING" id="1076935.U4L954"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX15505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118677" checksum="83BBEDA610591470" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9I1</accession>
    <name>U4L9I1_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9I1"/>
    <dbReference type="OrthoDB" id="10471108at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651400" evidence="2">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="13436" checksum="882B569BBA6037E8" modified="2013-12-11" version="1">MLFNQLIAFLAFLGMAIAQSSAASEEVVYVTVRNTVYSTQIATVTATGIPPVSAVEQYSTAASAVYTSIHTSDGAPAPSGIAAPTGSYGNVNSTTPDNSTIPSLTPQQPQSGAGFNKVSTGLALIVVAAGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA02</accession>
    <name>U4LA02_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935330">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LA02"/>
    <dbReference type="OMA" id="TNTQQRE"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11347" checksum="C8F561098035D55C" modified="2013-12-11" version="1">MATSAPSRPRPQGNTVESDEDSDYDSEFDEVVPQQNQQLQQRQQRQQQQNQQQQPGQVQQQQPQKEKKGGAPSVRIDLNIELEVTLKARIHGDLTLALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA95</accession>
    <name>U4LA95_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA95"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="280" mass="30553" checksum="5A78003DB94DAA9D" modified="2013-12-11" version="1">MLSSIDVAVNISAGIACPLWAPLKYVLLVAIDYVRAAEEILRMMETLKRHTDRFNIYQKLHDSQSVQIALLRVYTDIVKFSVELSRYFQQSIPIRAFKLAIRPFKEAFGDLMSNLTENVVHVHDEVKATELVRQSQHRDEISSQVHSIDTNTKSLTTEVANIGVELSGVSIVVSNIDNIVTSLAPTVAEIDVEVCGVSTAVGNINKNIVSLVPAVGGIEVNLSNLATDVANMQVTFTAGISQLDARITNTRTATPRSDNTGSSTAEISTRVSSHIYSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAJ1</accession>
    <name>U4LAJ1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAJ1"/>
    <dbReference type="STRING" id="1076935.U4LAJ1"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="395" mass="43408" checksum="514E0AD6B7E9CF0D" modified="2013-12-11" version="1">MARSSRLTRLDAFSKTVEDARIKTTSGGIVTLISVLVVMYLIAGEVGDYRRIEVVPELIVDKSRGEQLPISLNITFPHMPCNLLTLDVMDVSGEQQSGVTHGIHLTRLSKFPESSPIDITALDLHADEAPHLAPDYCGECYGATPPDGKKCCNTCTEVREAYEKMGWAFGLGEGVTQCEREHYGEHIKAMSEEGCNISGHLQVNKVVGNFHFAPGKSFSTPQMHVHDLQQFFESPKEHKLSHTIHHLSFGPDLPVGEVSHNPLDGATHEAPERAYNYMYFIKVVSTSFLPLGVKPGQDGAIETHQYSVTSHERSLQGGSDKEHPDTLHARGGIPGVFFSYDISPMKVVNREVRQRTFVGLLTGICAIIGGTLTVATLVDRTVYEGLGKMKKMHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB43</accession>
    <name>U4LB43_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB43"/>
    <dbReference type="STRING" id="1076935.U4LB43"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SATWCAN"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="109" mass="12446" checksum="BA097429D8C90398" modified="2013-12-11" version="1">MPTEIHTQAEFNNIVQGAPDGQLTVIDCYATWCGPCRAISPRMVQFESEYPTVKFFKMDIDKFQEFANIMGIRAMPTFFFYIGSQKVDEVVGANVTEIKGKIEMYSRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBB6</accession>
    <name>U4LBB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBB6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="19" mass="2257" checksum="50456F85E79586D0" modified="2013-12-11" version="1">MDPMDGNHFFVYFNKHGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBE5</accession>
    <name>U4LBE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBE5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="15911" checksum="90D37CFB5D29D1E7" modified="2013-12-11" version="1">MSPKQSTMHSTTITDRYKNAATLKAELDQLTAEITLAEEKAKSVENRSFNKIWDGFLKVHDTLLNAKKNLEDLRATLLQKDKETAQAIKTVEDRYADFLDASAALIEYVETLKMEGFRDQFRDMLAGHMAMKHPNSQSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBN9</accession>
    <name>U4LBN9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
            <shortName evidence="5">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADK2</name>
        <name evidence="8" type="ORF">PCON_05600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="5"/>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBN9"/>
    <dbReference type="STRING" id="1076935.U4LBN9"/>
    <dbReference type="OMA" id="TIAHFST"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
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        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="41"/>
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        <ligand>
            <name>AMP</name>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <location>
            <begin position="67"/>
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        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>AMP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="167"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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            <position position="200"/>
        </location>
        <ligand>
            <name>AMP</name>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
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        <ligand>
            <name>AMP</name>
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        </ligand>
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        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX29529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="256" mass="28124" checksum="1B383627C465FB83" modified="2013-12-11" version="1">MNAVTKLRKAMRLILVGPPGSGKGTQSGRLLSHFQMSAISSGDLLRENIREKTPLGLEAEKIIRDGGLVADDIMVGLIIGELSKRGWVESRSNLSSGVTVSGAMEMLGGTPKTTRLQACEAPSSSFLLDGFPRTKCQAKRLDEQVHMNFVVNLDVPSDVILERIAGRMVHVPSGRVYNTGWNPPRVPGIDDVTGEPLTRRPDDCPEAFAHRLKVYYESTFPLLEHYDKVGLLWTVKGNSSDEITPVLDEEILKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCI0</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="1" type="ORF">PCON_07621</name>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21739" checksum="1AF4097996517315" modified="2013-12-11" version="1">MYGWNLFDYIHARNISSGVSNWKHLVAQMMRCTVPGGYVELSEMEIKAHCDDGSMKADNGLKIYVEHLRESMRKMGRQIVDANLLKNLLEEAGFEDIQTFKAVEPVGPWPKDPKLKKIGAMTLLHTDGVFESYGMAAFSRVLGMDNKQVRDICERARLDSLNKNSHIYCVYYRVYGRKPMTMSMATRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD46</accession>
    <name>U4LD46_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Anhydro-N-acetylmuramic acid kinase acc. no. B0CAA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08061</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX08468.1"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="14178" checksum="F1D4A569FBCB3B28" modified="2013-12-11" version="1">MPSEGQTRSALTMAEGSFLAARLGKTAVTDMRIAEQSVGRQGAPIIAFFDGLTLQHPTIPPCLPEHRRYRQRLLHPPYFPRERRNGRNLRLRHWPRKHVHRLRHASLHQRRDGVRPRRKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDL9</accession>
    <name>U4LDL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDL9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8744" checksum="EBF9E32DCE2B29E2" modified="2013-12-11" version="1">MAPRHDGADDPKTAFYTMPHLSSIPKAPRNPWIYRKAPSYGCSAKNWVAVGGMLRQAEYVVRSMKPAFARKRHLVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDU6</accession>
    <name>U4LDU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935447">
        <property type="protein sequence ID" value="CCX09254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDU6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7537" checksum="7046B115092DDBAC" modified="2013-12-11" version="1">MPIDTGRWRYEILLSLSHSEPKAKGTSVVPSVSQNLTDQRAVPQNERLFQATHICSSSLTTPLGEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE77</accession>
    <name>U4LE77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Aquaporin-2 acc. no. P0CD89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935469">
        <property type="protein sequence ID" value="CCX09528.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE77"/>
    <dbReference type="STRING" id="1076935.U4LE77"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GTMQANV"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX09528.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="322" mass="34083" checksum="3AB6FE053A25AD5F" modified="2014-03-19" version="2">MAGKNRSSTSTTPIADESGLSGRRMAHNSPAKNCMPFPLYVFSYDQGLTQICSDYRSCMFSAFRGQLQILTTEQTGEFIGTFMFLGMAYMAVQAVVNAYTAEQSISKLLYIAFAFAVSLTVNVWLFYRVSGGLFNPSLTLAFVLLRLMPPMKGALLIAAQLLGGIAAAGVAQAITPGTLNVETTLGTGVSTAQGFFIEAILTAELCMAVLMIAVEKHRATFMAPLVIGCALGIGHLVGISFTGASMNPARSFGPAVVSANFEKSHWIYWIAPSLGAAAAAGIYKLLLVVDYTTSNPGQDSDGSDIESRGTVFIDETAGEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LED1</accession>
    <name>U4LED1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to Probable ATP-dependent permease acc. no. P25371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_07684</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LED1"/>
    <dbReference type="STRING" id="1076935.U4LED1"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FNCQLDA"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651298" evidence="15">
        <location>
            <begin position="22"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="882"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="372"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX29887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117207" checksum="4956FFE4EAE89AAB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEU4</accession>
    <name>U4LEU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial acc. no. P40915</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEU4"/>
    <dbReference type="STRING" id="1076935.U4LEU4"/>
    <dbReference type="eggNOG" id="KOG3196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERTMHYL"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX30649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="304" mass="33189" checksum="0F9A12A276D5D255" modified="2013-12-11" version="1">MSFRLPSRLLFAGARRQIVAVPTQKSIVRSFSECGVRRSDALAVHRNTTDNNPSIPFKFNEQNQKLMDEILKRYPPQYKKAAIMPLLDLGQRQHGFCSISVMNEVARLLEVPPMRVYEVATFYTMYARDPVGKYHLQVCTTTPCMLCNSDEVMEAIQSHLGITPGHTTKDGIFTFSEVECLGACVNGPMVQINDDYYEDLTGPKMIQLLDALKAAADSLPAQLPMWDEPAPTGATSGKGTGPITGKDKGVKSGKGINTGNGQKVGGVRVPEPGPVSGRQTCENSAGLTNLTGPKWGPEVFRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEX1</accession>
    <name>U4LEX1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="HF935418">
        <property type="protein sequence ID" value="CCX30097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEX1"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHITLCH"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="6">
        <location>
            <begin position="71"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="5">
        <location>
            <begin position="387"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="4">
        <location>
            <begin position="553"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="815" mass="92867" checksum="6C46DD5F913EA268" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFG1</accession>
    <name>U4LFG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Translocation protein sec63 acc. no. Q9HGN7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="614"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="689" mass="76284" checksum="CFE7795F51CA3213" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFI7</accession>
    <name>U4LFI7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFI7"/>
    <dbReference type="STRING" id="1076935.U4LFI7"/>
    <dbReference type="eggNOG" id="ENOG502S247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WDSSANV"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="39017" checksum="81CD9A9AA3145476" modified="2013-12-11" version="1">MFSKSGSVSGKQKDPVRKNQNDDLPPPYSATPDDQQSRCFPDKKEKNQYEDRNPGEASGSSNNQYHHPTNLTPARSLGAADGYKQIKEKDAFAALAAYDIVLLLDDSDSMELTLDGNRLLVDEKNATGGQKTRWKHLEMVVHQIAERIIPYDDDGIDIYFLKYKTADGNDKFNINKADQVWKLFETVQPTGKGGTPTDDKICAITKAYLDTYKQYLLGNISIIKPMNISCITDGQPNDYINLTDIIKLTARKLKALEDEHRANIGNRELRQLGIQFVQVGSDDEATKFLQKLDTEFEKTPGNPYDIVDVFDYEQWLKNSSSGSTLSGEALAKLLMGGIDPKWDTADEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFZ9</accession>
    <name>U4LFZ9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_08666</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFZ9"/>
    <dbReference type="STRING" id="1076935.U4LFZ9"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GATEYCY"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651973" description="Crh-like protein" evidence="20">
        <location>
            <begin position="21"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="291"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX30467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="402" mass="43212" checksum="6EA458AEA945AD11" modified="2013-12-11" version="1">MHANFFKLAAILATSSMALAQTWTHCNPMKKTCPDDPALAGTYDWLYGGPAPDFKVLAGKDVLKYNDPAAGGAIYRVEKRLDAPTIVSNFYIMWGRLDVTLKAAPGGGVVSSVVLQSDNLDEIDWEWVGSHMDEAQSNYFGKGNTETYDRGGVHPCNATDFHTYSFDWTQEKLDWLIDGQVVRTLKPADVKGDFYPQTPMQVRIGSWAAGDEHNAKGTIEWSGGPINYAAGPYDMIVKEIKVIDYSNGTAYRYSDQTGSWKSIEAVGGTVGAGPQTGKGHQTGIVDPSAEVETFDPSSSAAKSKTGLLIPTTSDGSQALETGEPNQRDRDKSKDPADPLEFTPSPTSPSSPPTSGFKGEMKTSGYPTASETTVPLVVSSDARRIGSGLPLVGVAWLVIGWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG64</accession>
    <name>U4LG64_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Lysozyme acc. no. Q37896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG64"/>
    <dbReference type="eggNOG" id="ENOG502S6UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HLNENQY"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651423" evidence="7">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="28632" checksum="7858A19BF66507B9" modified="2013-12-11" version="1">MYSLTHLLTTSLLFLAVSAYPAKETLRCRTSPSTSASIHKTYPAGADIKITCQTTGTKVLTSNVWDKTSDGCYVSDYYVSTGHSGIFLSKCGTSGGPPSGGSGCVAPINAATISLIKSFEGFVPSPKPDPIGLPTVGYGHLCKKKGCAEVKYKFPLTEATAAQLLQDDAYTFRKCVAAAIKDSVTLTDNQYGALVSWAFNVGCGGVQTSTLVKRLNRGENKNIVASQELIKWNKAGNPPKPMNGLTRRRNAEIALFKKASSVQAHPPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG77</accession>
    <name>U4LG77_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_10213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG77"/>
    <dbReference type="STRING" id="1076935.U4LG77"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="189"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX10619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="581" mass="65039" checksum="03B0AD0A6C89C5F8" modified="2013-12-11" version="1"> </sequence>
</entry>
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</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
    <sequence length="182" mass="20593" checksum="362DB2CD31A4F9EF" modified="2013-12-11" version="1">MATSCPPGLDLTDVDSTALPQNLRTTDPLITALVNYKIGVETLFANFAEMETNLGSVGFHNESDASIAPTKYVIMAINYRNYRELPVSPQELQDAVLIEEMNEFLYKIVEATGVMSTFRYLRQDVEWELFQTNVQMFSENLKELEMAVRTEEAKGIWIRLFGKLGILRAEALKCITKRGALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI15</accession>
    <name>U4LI15_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI15"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8611" checksum="6FA139B1D58096B3" modified="2013-12-11" version="1">MAYYTRLAARNGAKQGEEPMYTPKKETPRKRGTTAGELKKKFAAQRTKASVFKGAMSPRKPWRRAKKGKKAGRVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI56</accession>
    <name>U4LI56_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI56"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="14707" checksum="4097EEAB506C094E" modified="2013-12-11" version="1">MEDIAMDDVAIGLISILWMEFPRIFFTSPFVLATDQYRNPLAPWYEQSSTTAHASQQRVNPFMRVGESSPISDMQVGILFSPDDAEIPTYTGWPNYPTFLTVLHRRKSTFDVFSLCQSEVNYERNSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJB4</accession>
    <name>U4LJB4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJB4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="7209" checksum="48A0120DEE679D30" modified="2013-12-11" version="1">MGNYFSFLCLFSESSQVSGFCWCPGQLSNRRKVFFSLIDVRGLWQFYRCCFSEFLCSVFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJD2</accession>
    <name>U4LJD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJD2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9246" checksum="7D3D44C812E1D170" modified="2013-12-11" version="1">MDHRGSQMTTVYVLGISHPISLSLTSFRLKNTSGSQKPKQTLNTVQTWNQHPFLRCSSCRSGGLSLDPKKQDIRHRYITGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK26</accession>
    <name>U4LK26_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Mitochondrial GTPase 1 acc. no. O74776</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935851">
        <property type="protein sequence ID" value="CCX32449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK26"/>
    <dbReference type="STRING" id="1076935.U4LK26"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPHANAP"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="281"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="507" mass="55133" checksum="E23A09D12DC9DFFE" modified="2013-12-11" version="1">MAAYNFRFSARLCTHISSLGRISQSIPNPSRTSPLRSWPDAGCGRGYAAIGGSTPNEQPHANAPEIIESLSAQTPTATSEAATLGASETGAAETLEATTSTSITETLAPAASTRASSSIPTTSPTSIPPFNSTPTPAPLPPTPAKGPARRDGFVPRDVFPVPASITTSYFLGHHKAGLDRMKELVGQVELIIECRDYRVPLSSRNPLFEETLQGKQRMIVYTKRDLAQRVLDDNTRKIMTKWHYPHTVAFSDTSNPKDIAFIVNHAKKVARDHDSLTGTRMLIVGMPNVGKSTLLNALRRVGTGNSTKAAITGGQPGITRKIGGTVKITGQDDPLVYVIDSPGVFVPYMSNGQTMLKLALVGSIKDSLIPIITLADFLLFHINRNNPGLYKDYCPPTNDVMTWLKAVARKTGKLVKGGEEDYEAAAIWLVGRYRKGMLGRFMLDEVKEGGYQEWLEGEGKAGESVTQARKRIKKERIEAGRKRNMETALPSPEQSSHNIPWSVTMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKZ4</accession>
    <name>U4LKZ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKZ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2317" checksum="1418E53C9ECAB9B7" modified="2013-12-11" version="1">MLDTPNVCRVRGREPLTKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL10</accession>
    <name>U4LL10_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13468</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL10"/>
    <dbReference type="STRING" id="1076935.U4LL10"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="734" mass="79873" checksum="0B743C0D3F3B000C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL23</accession>
    <name>U4LL23_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to GPI transamidase component PIG-S acc. no. Q5XI31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL23"/>
    <dbReference type="STRING" id="1076935.U4LL23"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="575" mass="62784" checksum="5B2A9E7599D7C234" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL83</accession>
    <name>U4LL83_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL83"/>
    <dbReference type="OrthoDB" id="10383034at2759"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652419" evidence="1">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="233" mass="27458" checksum="95C32878C8BA7367" modified="2013-12-11" version="1">MMSQGFLFFWLSFLQLFAPAMGFSFFGAEQRDASYKDISTRPYIRNDTMPRCIHLLANYTNIANRPDPEKHENMYDASGKAYDLIQTWCGHYKQENNTFIVKDWDKWWNNDDGITKFDREFMKDLEAQGDKDLVFELIDLAHNLGTRPLNVFLWKVLLNMYEDEPADTALWDFLASFELSIQVPTPPEVTDDWLEEVITEVMLPEEHTVNEEMEFLPVLSTFMWEMMMGRSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLK6</accession>
    <name>U4LLK6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLK6"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="27685" checksum="560031754B8CAE22" modified="2013-12-11" version="1">MTPKTPIHVSISWVRTRYPRPSQLWSFLEPIDKDFIIDNFLHIILFEGVPDEHLRHPGPLRNIVTTHKVPSKIRSYLQSIDKSHLIGHCVNLVFASAAKMNHCVYCHKTYMINWEESCRIRHWGELKVVHNHELELSCCGQRLSTKDYPSLANKPKHYNYSKSDYESFIRQKPFCYSGIHHSTPIITLAEADLIDDSHRWRIKPCYMPGIGGLCCEKMECEKATLGIGMSKKHTGNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM53</accession>
    <name>U4LM53_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM53"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652165" evidence="1">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="109" mass="12213" checksum="A66E9663E4590D2F" modified="2013-12-11" version="1">MILSFPHLLIPMSSISPFPLKFPALLSLLFWFPRSLCQDRAPSCHGDFHCLYVVLSNPNGSLLYLGIGIDDINLAITNRTRVHLSSLFRLHLSPSYDLSPSSQGDFQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM98</accession>
    <name>U4LM98_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM98"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652176" evidence="2">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="90" mass="9861" checksum="8D13B01A216535F9" modified="2013-12-11" version="1">MVRPSPNLHALALLISVIYALQLTPVNANNPRHTYDTLHYSTNDVGPPGQPQKISQKGIPSQESMHAAKIFFKPGLVGSSLIEAHFYLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMA9</accession>
    <name>U4LMA9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMA9"/>
    <dbReference type="OrthoDB" id="10448284at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="27654" checksum="9F4F5434B80A6C79" modified="2013-12-11" version="1">MSAPPTPRLRLSRPGDPSRPTQPLKSALSTPTKRKRPVLEDDLEEPPESLEDELESMSLDPEVSMGMGMEEDTDTDLVGYTQPTQQHLTVPGTGPGPAKRRREQRSASEPRRGLNGLQGLQGLRGLTPPRSPEQEQGMQRKRLRSPPPEPAQEELELEQEEEMTDAVLVKSTPLQKYARALRRKEQIQNYKSREIKESREKRTAERRRRRSQSNASRAVELEAINAAANARLVVDSPQKKVQFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMC9</accession>
    <name>U4LMC9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_14129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMC9"/>
    <dbReference type="STRING" id="1076935.U4LMC9"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCRGHFP"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13645" checksum="927D3A1567B59BC2" modified="2013-12-11" version="1">MMSSTRIPDAGVASEPAQTEPQRAPDGTLRLRGAPIQTRRVTWGEDVVDNEHLGKKKSKVCCIYHRPRDPDDSSSSEESEDDDDDDNSDSEKPKKNAYEKMPKQKKRHHHHHHDHTMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMD6</accession>
    <name>U4LMD6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMD6"/>
    <dbReference type="STRING" id="1076935.U4LMD6"/>
    <dbReference type="eggNOG" id="ENOG502QTVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPLAHIC"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="441" mass="49866" checksum="744CE66CBD38FCF5" modified="2013-12-11" version="1">MTQYVEYSRHDNESMTSSSASSSEYDSSSREGSVPNSVPSLDHRHNSVESSFTPLESIFDSDPHTSANTYCTTVASCDDDEDDHYNGRFGYIHQIQQTATPATPEEFAKLFPSGEKRLLIKHDDSTLDGHMNVRVDTMAPATTRMPERRLTLFHVRMYDIHDRDFSVRRYGRECGREVAHVKRKMQKTIARPNLQRSVSKALSSFMAKHDSDPECRKLERSDSGYGSVDEEEDSSSGTTTPANKKATNTCTLEFSNYAHVDLTRKGAKTAKKYDFEYWGKSYSWRRTIVGEHIHYSLTNNATANIVAQIRPDTLTPYMAAIEEAKGGFVPPSSMYIYNNKADPVNSSNADVADVIVTTGLVALIDDCIKRKSKTKRTVQLTLPTRGPTPLKMDMEYVGPKKFLEEMFHRKPKPLVRSSTMPEQHHQYQQSRPTPPTRTMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMV5</accession>
    <name>U4LMV5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Protein transport protein BET1 acc. no. P22804</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMV5"/>
    <dbReference type="STRING" id="1076935.U4LMV5"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFWVWIT"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="21190" checksum="50D74172B624B4BB" modified="2013-12-11" version="1">MPPRLLAPPTLVAHPQLISKFQSAVLFTRAMSSRYGPSTRRDETYAGSNSTQNDRYGSPAGYGYRQNTYSHDNLNTPPPFAGGYRAATPNRKGQYSAAVMEELESQNDAAVEGLSAKVKMLKDITVAIGEEVRQSNSLIETMNEQFAETRQKLGGTMKNMLRMARRTGVGWKAWVAFFAAVGMLFWWVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMZ6</accession>
    <name>U4LMZ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMZ6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6348" checksum="C5166EB10A217A4B" modified="2013-12-11" version="1">MLQSTCTCSAADSAATATHTRPPEYHLTKRMPSVNRCGWESTITEGVRLELRLGISVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN77</accession>
    <name>U4LN77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized protein P23A10.12 acc. no. Q9P7X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN77"/>
    <dbReference type="STRING" id="1076935.U4LN77"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACDVNGK"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX15870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="265" mass="29436" checksum="E965B28424019433" modified="2013-12-11" version="1">MVSALRFKGEKKKKRKRAVDDGDDTSAEPSAKAPKKAYDEDIEGWADAEVLEDLTGPIMLTLASNPPVALAADAAGSVFCSPLTLITGEDLSTAEPSDVQQVWICAKVYGSSIKYSLKSHLGKYLSCDKTGVLTATREAISAEEEFVPVRRDGRWAWTTVREKFLGVEETSKGVQVRGDRDDVGFREGWTVRLQKRNKVKVKEGASEEKGRVKDRVSRKELEELAGVPLDDDQVKMLRRAKREGGFHEALLDVRVKHGKHDKFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNB0</accession>
    <name>U4LNB0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936082">
        <property type="protein sequence ID" value="CCX33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNB0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651603" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="7544" checksum="52C1CB1C5226C802" modified="2013-12-11" version="1">MKLSLILSAVFAAAAIASAIPEAEAAPAPEIEKRDCYTTSCGGEGCKAGYTVKNIVYCNQRFGIIRRICCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LND7</accession>
    <name>U4LND7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Plectasin acc. no. Q53I06</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the invertebrate defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LND7"/>
    <dbReference type="eggNOG" id="ENOG502SVYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187789at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00107">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0211">Defensin</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651605" evidence="4">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="5">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10130" checksum="08D1FAA5D2204411" modified="2013-12-11" version="1">MQFTTILSVGITVFGLLNTGAFAAPQPLPEAHAVSDPEANADRLAGMDAAQLQKRGFGCNGPWDEDDMKCHNHCKTIKGYKGGYCASAGFVCKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNP1</accession>
    <name>U4LNP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936354">
        <property type="protein sequence ID" value="CCX16189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNP1"/>
    <dbReference type="OrthoDB" id="10662506at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="90" mass="10819" checksum="CA069B13B3C0B9E4" modified="2013-12-11" version="1">MDIDSSEYQNVDYYGNDYKDEEYEDEGYEDDGYKDKVLELDSRIMKWRDEVYELIPLPQLYMMQNDDSCPYPMTWESLPAGLRLFFISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ22</accession>
    <name>U4LQ22_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_03884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="HF936562">
        <property type="protein sequence ID" value="CCX16995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ22"/>
    <dbReference type="STRING" id="1076935.U4LQ22"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFVHTYE"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
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    </dbReference>
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        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="USP"/>
    </dbReference>
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        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="332"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
            <begin position="682"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="253"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
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            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX16995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116467" checksum="1A9C33D8BA90275C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ35</accession>
    <name>U4LQ35_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Similar to GTP-binding protein Di-Ras2 acc. no. Q95KD9</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_04061</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936578">
        <property type="protein sequence ID" value="CCX17132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502T21N">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="386" mass="44642" checksum="97636DC78CEF084C" modified="2013-12-11" version="1">MLVERLGQHNSSLSLLLTTLLCHSMVQVEQYMMELRAEVASLTRMNHRLLYFLERDNPSWSETDLEVRASSATRFDFDETLARSSAYRGSRIDVTAAQGSMITRSTNRTSWTELSGRSLAQVENVADILLPIYYDDIESSSQWFGSVETIEEEPETDIIDYEDWRQPQPRFLNFVSEDQYNQTRGRYPIPQKRISISLLGWTATGKSELLGRTKFAFSAPLEIFVTSILSNNVELRVHDVMGMEEHVRLHRAVISAGDAIILVYRIDLKHSWEVLKEYAGYILQTKPDRRKHPVVVFQNKFQDDADPNELLSFRDEGLPMIGQTEIHRAWAMMKQFQFVVGDSRDSAFVAEMLEGLAKRRMAWLSSAKRKLNYGRKWTWTQGILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQW5</accession>
    <name>U4LQW5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="12" mass="1333" checksum="D27F833AF165BEB9" modified="2013-12-11" version="1">MLNDFCSGFELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRD0</accession>
    <name>U4LRD0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1774-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936618">
        <property type="protein sequence ID" value="CCX34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRD0"/>
    <dbReference type="STRING" id="1076935.U4LRD0"/>
    <dbReference type="eggNOG" id="ENOG502REZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWSILVY"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31202" checksum="7C66E8C954E68177" modified="2013-12-11" version="1">MAFSNPFSRDVEGTRRNITAYRVLTLLSFLLQFITTLYYTRNAPTDDHTGHHTIFQYHSTPFTVSYIFVSIYWVVLWIMQMVYVWHLFRSDAEAVDSAAAVGSHFILYNVLHFAWVMLWTRGHTILSEMILVINFLQLTAVYFRHHTAPRLVHNAVSAMPLTFTFFMLLWNGAVMIHCYSLVCRVLANVAVWGLAAFAGFFLLAFRDYYVGFATAFLAAGLGVGQFFTKIIALQWPFAFAVMAIVFCASIFTAIPGSFGSNERSGERAPLLHESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS18</accession>
    <name>U4LS18_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_03556</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS18"/>
    <dbReference type="STRING" id="1076935.U4LS18"/>
    <dbReference type="eggNOG" id="KOG2090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="300"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="809" mass="90393" checksum="9D882665150FFF1D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSE9</accession>
    <name>U4LSE9_PYROM</name>
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        <submittedName>
            <fullName evidence="10">Similar to Inner centromere protein-related protein pic1 acc. no. Q1MTN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LSE9"/>
    <dbReference type="eggNOG" id="ENOG502S0AD">
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    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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        <location>
            <begin position="1391"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="763"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="635"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="905"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1115"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1167"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1496" mass="165124" checksum="E775831F5D6FACBC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT00</accession>
    <name>U4LT00_PYROM</name>
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        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651882" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36517" checksum="B9719C95D74899FF" modified="2013-12-11" version="1">MRPIILLSAILCSVFVNAQIVFVNAQSDQVNEAADIIYNNDYESWCSAWLPPVTRTRISTIRVNARTATVARSTATRNVGVTRTATAVTTTTITQTSTVTMTAPARIARRQAPAGRPVKPADLARFSDAILTEACLFLVEPRTATITQQTTQTFAARTVTIPVTTTTISSPTTVTRVATSTRTAAVTVTRTVSSDRNTPTPPPPPPPPSGGGSVDADNDRGNEESIAGKVVPSGASQCRDFTGNGQIAVGVHQYSFSRPVGRDAYVIDWNVKNAQDCCNRCFSSAMGCAFWRFADSCLIIANPTRANQCADIRPVVTVTTGGKDSDSMAGPGGCGWQIQRARL</sequence>
</entry>
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    </gene>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT09"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5747" checksum="4E9F145D9E7D53E2" modified="2013-12-11" version="1">MELFYARSVPDTWQWPPGQPAWRAPCTPTVVGSKLREVHLHSISLESAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTF0</accession>
    <name>U4LTF0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13641</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
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            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTF0"/>
    <dbReference type="STRING" id="1076935.U4LTF0"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="129"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="255"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="583"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1023"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
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            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
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            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="639"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="11">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117856" checksum="1B1D9A59B540BED7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTI5</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTI5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652368" evidence="2">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="12890" checksum="FB7D602CE7DB5459" modified="2013-12-11" version="1">MLPISLPILVPGALFTLFVWKLSAAPRNTSYHRFSMAAPETAARIRGDELYDIRQNHISLHGGTPVKPEPAISQIDVLSEVIKNRGQAGRRRGSGSARSGKGHRRSSSMPAMELGSKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTS3</accession>
    <name>U4LTS3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Anaphase-promoting complex subunit 8 acc. no. O94556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTS3"/>
    <dbReference type="STRING" id="1076935.U4LTS3"/>
    <dbReference type="eggNOG" id="KOG1155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERCLYHS"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="11"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="570" mass="65502" checksum="6BFD9246B850EA86" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU15</accession>
    <name>U4LU15_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU15"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6702" checksum="7F3203F562674DF3" modified="2013-12-11" version="1">MDTQPYGGCDHTKIPRYQGSEAARQRTEPRFLVLGSVLGSWTRTERLRFTLTAQIYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU85</accession>
    <name>U4LU85_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU85"/>
    <dbReference type="STRING" id="1076935.U4LU85"/>
    <dbReference type="eggNOG" id="ENOG502SCQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKGVAPF"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="586" mass="64629" checksum="CFC3872AE910704A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUE1</accession>
    <name>U4LUE1_PYROM</name>
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        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 27</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PCON_11017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX31576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34645" checksum="37F06622BAED3E80" modified="2013-12-11" version="1">MSRLPASPAANLPATNATENPDEAEAKLLEQLRELDELHTRLIGLRTIMPTLLWPIRANYPDPSRMFDDLSHRVVNASQDIKVFNTKWVNNAHIFENAQKSPKDTSSPENRLYPHDLFVPPETSNSDTEVVEIKVETPIKTEEEEEPQVQDTTFEEIEDVIEEFSGRLMHRNVKIDHTEDKIIVNLPLPANLSFTINLTPHSPTPFTVTSISTPPLKTSRGRSSMLQRHQTHLHRSIMRSISGRQWPGNLEVLLEMLASYKTIFTETCEKCKRLTTGQNLELATVRKAVLVKGERKWVAAHEGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUE3</accession>
    <name>U4LUE3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUE3"/>
    <dbReference type="OrthoDB" id="10407628at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="696" mass="78153" checksum="A2500B7422EBC55B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWU4</accession>
    <name>U4LWU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWU4"/>
    <dbReference type="OrthoDB" id="5489720at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="302" mass="35377" checksum="FF6DAD2CACDAC2B1" modified="2013-12-11" version="1">MASSPTSRNSALTPDPSEAPMEFQNIESPVDTHEKDGKEQEGSFEVPLFNFDEVMRYMRKLKEENVLLKEDNESLKEQLAIIKKEYEDKPQMDEDFEKLRQDKMELEMKLQKVLQYGTVKGMENVWEKCGGMEQKFREMKEEMKKELKQELEEEMKQELKKELQQQLKHTIEEPEENLASVSKKLKQVSKEMEVVKSQLTELNSEFLADAFTASGIKYISRRPIPDGNIEITGPYDAHLYYVERSFLGTYDDFAGLVFGLWALDLWDLGDELTRIIFNEKEMSYPEWSSKWASMIVKNISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTZ3</accession>
    <name>U4KTZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTZ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7290" checksum="E0AEE23C71EB1E7E" modified="2013-12-11" version="1">MFGVHQMIRLKTPFHSVDIDRAISVCRKFVKQNLTQNIQTAATSKPQELFYHDQGDTPQDSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU45</accession>
    <name>U4KU45_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">PCON_03639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU45"/>
    <dbReference type="STRING" id="1076935.U4KU45"/>
    <dbReference type="eggNOG" id="ENOG502S3SI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TNPHEYF"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21279" checksum="C76D883E100CF4C7" modified="2013-12-11" version="1">MASLKSWLPWGGSNTSTPAPPPLNASPPATPPAPAAPAPPSQNVAAAQPPMSEGKRILKQLALPAFGAAFLLLSVRMTRRSTARKLRETIPPYYHPNNAPPVNPPNGAMDALEALQLATLNVFSVAMLMIGGGAFAMDVSTIEDLRERFKATDMGEEWEKTNKAAEEEWEEWAVSILARKELKDKAKAVAEAEVAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUF3</accession>
    <name>U4KUF3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C211.03 acc. no. Q9P7R8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935219">
        <property type="protein sequence ID" value="CCX04903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KUF3"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CRDIRHH"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="630"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1588" mass="175427" checksum="3DE2E6EBF6968E3C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUV8</accession>
    <name>U4KUV8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Negative regulator of differentiation 1 acc. no. Q09702</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUV8"/>
    <dbReference type="STRING" id="1076935.U4KUV8"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIRWSER"/>
    <dbReference type="OrthoDB" id="2935572at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="215"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="475" mass="52184" checksum="FD4E401B6F9BC925" modified="2013-12-11" version="1">MPSNLHPTDTTVNSRYEDTFAAMATATGNGNDYEASYDHDTVLVAREEYQTLRTCYDEYHALRNTLLNGGVTEENLQILIITGLTAAAAANPPLSPQLPPTPRSDSTPLFAPPTRASVRLSKDPNTSTNGTHDGKHGNGIHGNRGHGHGYGNAVHSHHAADSYPSPERESSSRHGGGHGHGHTNNQSTSHANSHANSHANSNGNGGQVIESKARRTLFFCNLPKEATYADLVAVVKGGPLVDVWMKNQDRCASVSFVNPEDADNYLRWGKQNGVVVLGRRVEIRYREPSRQFTILRNVLRQIQNDGASRILRLRNVSLSITDQRLRDDLDHIANLRIEKLIRTSPTEIICNLNSVCAALFARTCLRSRAAYKGCKIEFGVDECAQPLPDQGAYYGKQEKQGRNTGDIRGRNRFDVFSEDMGFAEDGGRNCRRSSLRGGSETTETQEEDTEEDLQSWADETADHTDGGADLSGYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUX1</accession>
    <name>U4KUX1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_03899</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935219">
        <property type="protein sequence ID" value="CCX04902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUX1"/>
    <dbReference type="STRING" id="1076935.U4KUX1"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:translation elongation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IP08861P-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Med26"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc beta-ribbon"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_TFIIS_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 13" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="82"/>
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            <begin position="119"/>
            <end position="144"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX04902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="309" mass="34048" checksum="FC8C6F1DE40B2AFA" modified="2013-12-11" version="1">MDAKDVMTHVSNIDKAVRDKLPADHLIDLLKALQSGVVATEKLLRETKVGMSVNKLRANSDKNVAELAKEIVTKWKNDVHLAKNKASSARAAADKPRSAASPTTSQRPITPDTRAGSKPVQSNAKAASDPMQRNKSADNVNCSVTGDKARDSMVGILYDALCIGSNASPDLILSVAKDLENAVFANYKRKIDPMYKRRIQALFLNLKNKSNPNLRARVISGDISTARLATMETKEMASEEMKKENERLEQENLRESMVAKAEKSISDQLQCGKCGKKRVSYTQAQTRSADEPMTTFCTCENCGHMWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV94</accession>
    <name>U4KV94_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="167" mass="19837" checksum="27C0E230BEE717EC" modified="2013-12-11" version="1">MDRTKQIKRKASDIDENSEPALKKPDIDDEQIDEISDIIKKYPTRRDFRTYLESIDKKDVIAEFLGVVFGYGDRRHCLYCHQDYDALNNSGCVVKHFGEEQSLDEPDEEYNDVEMDCYGQRLNYIIDHEEFLQPPREQYPNCYEGRHWDTLIVWDPDEDDSNAEFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVA6</accession>
    <name>U4KVA6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_05015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVA6"/>
    <dbReference type="STRING" id="1076935.U4KVA6"/>
    <dbReference type="OrthoDB" id="5372266at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="525" mass="59992" checksum="B2EC75618CE1705A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWV6</accession>
    <name>U4KWV6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWV6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="19115" checksum="B6E1813591D3182B" modified="2013-12-11" version="1">MASSSPSSSDKMFADPTQFSDHPAVDIKPDEPANKPKISAADVPVPRSFILNLTGEINWLKKDIGFKEQEIETLRQENTEMQCDLDVLRQEMVEMQYEIEVLQQEKMKIHEKLQKITHYINTSVCGHAGHGKIDEAIMKQEFEKRLREMKKEMYTEIYERITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXE8</accession>
    <name>U4KXE8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935315">
        <property type="protein sequence ID" value="CCX06807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXE8"/>
    <dbReference type="STRING" id="1076935.U4KXE8"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="129"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX06807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="392" mass="44015" checksum="134CFD525FA80FED" modified="2013-12-11" version="1">MRGTKDAPTTTRSRPTRHASSDKENATPSTKLQQNAPITQQSCRPRDMNSTQVLHQQYLKQAGDLSKYDPDQPAEERRKVRRGYRDLQRRLDDNKSEFLRADNNGLLEIIQSSDQLYQNVKQTSDATLDSRLLVSATDLALKKVSNFVVGSSGVGLDVDEFVGKCISYMKNANAVPGRRGGRNEDGDDDDDDAMDWAAFGRAMSFKGNKRAPTKDFLLGPLSVQKKIRVVKARKMGLGRKKGEKAAQPTDVNASDIVDNEKETMRMVKQIYDLLKRTMEADDSIEFFSLFDVVVNPSSFGQTIENLFYLSFLVKEGKLAAFDDEETGLPMLALTEVATAEQVASGEAVRRQTIMSMTMWEWKQIVETFDIKQSIIPTREKENVTIGANGWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYC9</accession>
    <name>U4KYC9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYC9"/>
    <dbReference type="STRING" id="1076935.U4KYC9"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NLHRHAD"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="561" mass="59025" checksum="FAFBED5B3D2C9D77" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYD5</accession>
    <name>U4KYD5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935296">
        <property type="protein sequence ID" value="CCX06555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYD5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="52" mass="6002" checksum="6E5B2C5941F433B6" modified="2013-12-11" version="1">MQIAFAACGDFYDVDRLLLPKKLHTYIHTTGLPPRGYCRGSIRLTWEGIYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYU9</accession>
    <name>U4KYU9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="13" mass="1597" checksum="0F93119EC3CCAB50" modified="2013-12-11" version="1">MIENFIYSHSVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZG5</accession>
    <name>U4KZG5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZG5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="150" mass="16949" checksum="D5DBFECA4458307C" modified="2013-12-11" version="1">MKATLNVTDPPRNKSLEVRNRIISYPFFSIPPPGTPRRPGGPYLSPAQLVRGRLREILVFRRSLVSPQGFDSGNIGIYPANRGKTAPPRLDPHHRTPRKPSAEEYITEDDSYTRHVWRSGDWGLKIDPGLTSRDGPGPELCSRPRNSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZL1</accession>
    <name>U4KZL1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cytochrome b5 reductase 4 acc. no. Q502I6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZL1"/>
    <dbReference type="STRING" id="1076935.U4KZL1"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GECMVGI"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="32548" checksum="7597BCEAE3E4D8F9" modified="2013-12-11" version="1">MWPFVSNLLRSSQSNLDSSSPDHRVTPSLCVGNPSESSTTSVTSSSPDTTPKARATDHPTSIQAIPEISLLPEDEDDDDLPPMFPAMNSAQRAGVPSSLPVNNKAIPTNMPPPPLPNRNPRMQNPSSWATVPSGGARQNPAAAARAPPRSQLAVQGAGASGVAAGNGLTLPGRQGKSRKKVVLNPGHSPLDWARLQKSGINLRGLPHTSLLKVPPSELAKHKTAPDDVWMGLNGKVYNVSHYLPFHPGGERELMRAAGKDGTKLFNASHHWVNIDNMLEECLIGIMVSEEEATKKEGEGELDMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4L045</accession>
    <name>U4L045_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_07478</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L045"/>
    <dbReference type="STRING" id="1076935.U4L045"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="104"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX07889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="498" mass="55385" checksum="B579319E70A521AB" modified="2013-12-11" version="1">MAKLTGADVAQHADKNSCWVIVHGKAYDVTEFLPEHPGGQKIILKYAGKDATEEFDPIHPPDTLDKYLDKKFHMGEVDMRTVAIEEKQVDPDEADRLERVKNMPPLELCYNLSDFEYVAKQVMKRTAWGYYSSGADDEITMRENRTAFHKIWFKPKVLVDVENIDMSCTMLGSKSSIPFYITATALGKLGHPDGECCLTKAAARHGLIQMIPTLASCSFDEIVDAADGKQTQWFQLYVNKDRQITERIVKHAESRGMKGLFITVDAPQLGRREKDMRSKYAEDDTAVQKEGDTTTIDRSQGAARAISSFIDPSLSWKDIPFFQNITKMPIILKGVQRVDDVIKAVEHGVTGVVLSNHGGRQLDTAPTGIELLADVMAELRARNWQDKIEVYIDGGVRRASDVVKAVCLGAKGVGIGRPFLYAMSAYGVEGVCRAIQLLKDEFEMNMRLIGARNVSELTPDMVDAKGLAYHTIPSGPDMLHHTVYSPLTNPAFKAKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0N7</accession>
    <name>U4L0N7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_07357</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0N7"/>
    <dbReference type="STRING" id="1076935.U4L0N7"/>
    <dbReference type="eggNOG" id="ENOG502SD7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GMVWASM"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651209" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="91"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX07768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="192" mass="18298" checksum="3C549D723300AD3A" modified="2013-12-11" version="1">MKFSLVLAATVVGLASAQLPGLDKFPPCGLSCLTSNIGSTGCAITDFKCSCSNKAFIDTSTKCIQSSCAKADQDKALAAAKELCASQGVEIDPPVSDVPSSSAEPTASAPAPSSSAPASSSAAAPAPSSSAAASSSAAAPVPTASGSPSSSAAPSNGSYTPPVETQAPGSGAGRATAALSLVGLGMIAAIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0W2</accession>
    <name>U4L0W2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="4">CBS 100304</strain>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <end position="527"/>
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            <begin position="46"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="88"/>
            <end position="111"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07883.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="527" mass="59023" checksum="DD7A5045A190B087" modified="2013-12-11" version="1"> </sequence>
</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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            <dbReference type="EMBL" id="CCX07913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="16" mass="1941" checksum="565D3A5BB3A6039B" modified="2013-12-11" version="1">MPTIDEDRRVYACEKD</sequence>
</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 100304</strain>
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        </source>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="61"/>
            <end position="151"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX08365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
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    <accession>U4L1Y2</accession>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
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            <end position="52"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="10389" checksum="41F95A443BAA1442" modified="2013-12-11" version="1">MAWDCQCLFIYPEAVAVCFCEMVTAEGIAAEPSEHAQVKEESATDTTASEKPAEDAGFHCYASEGSSFKINGSCESIGCTAPTGEGAEGTTPSLVTAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2A1</accession>
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        <lineage>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="3">CBS 100304</strain>
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            <begin position="27"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="15149" checksum="2FBCB927D786F60E" modified="2013-12-11" version="1">MAELAIDNQRPMAEKRKRCEEEEVHEENENKKLKESKDEDEQRRRRKKTTRKVTKKNQDSLISSSASNRDAANMVAFSDSYYLTRFYEVLYNSAGTIDPYLLDYPSLSYYKDLPDCETEEELHRAIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2J3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Subtilisin-like protease 3 acc. no. P25036</fullName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935513">
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        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7218" checksum="A2725E090695247E" modified="2013-12-11" version="1">MAMDMGIAASTTFGIAKNAYIISVKVLPRDEADIVKGIDVILNRHKQRRKNSNFEGSVVDLSLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2R9</accession>
    <name>U4L2R9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Xenotropic and polytropic retrovirus receptor 1 homolog acc. no. Q28CY9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_10221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2R9"/>
    <dbReference type="STRING" id="1076935.U4L2R9"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETSHFYT"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="612"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX10627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="877" mass="101629" checksum="79E0B7E1351BAC81" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2U0</accession>
    <name>U4L2U0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2U0"/>
    <dbReference type="OrthoDB" id="10318483at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27584" checksum="5E8768FE43994831" modified="2013-12-11" version="1">MLRRIAIGIARRSGLQRKRPGPPQCEAPNSDAALPTSEYTHWFIKVLYGNNQVLNHVKFAGPLDKANLAARMYLEAQTGPEIKALCVNICDFGIYINPTERYPIGTGYVLAAWAEPCWHNCKLGGTKLYSDDQCFFASVNLLARAALTAEIVKATAVDGDYEIGYIFRGDRRQDVNKEKMKMVTATCTKEEVRQKVEAVFADACKTEIDFQTVDGVLDIWSRRDIGGVNPGELMVAWMIPNINFVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L306</accession>
    <name>U4L306_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Allantoinase acc. no. P32375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L306"/>
    <dbReference type="STRING" id="1076935.U4L306"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="25195" checksum="71647F1FC87C2FAB" modified="2013-12-11" version="1">MTSMSRLAVRWDRGMVEWMRKLVLFSLSFSSGLRGFKCFLIESGVRYPIPLSINSTTTIENFNEKLKAAENACWVDVGFYGGVIPGNEQELLPLVKAGVYGFKCFLIESSVDEFGIPLCHLRGRCKGHGETKGFLNRPHLLCPSHPLNADHYQTFLESCSQSFETYAIEQILAPDLELHSIHLAAGEGFDLVTKTHDNERRSGSKLSVENCFHYLTLAAEDIEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L426</accession>
    <name>U4L426_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Rhamnogalacturonan acetylesterase acc. no. Q00017</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L426"/>
    <dbReference type="STRING" id="1076935.U4L426"/>
    <dbReference type="eggNOG" id="ENOG502S0FZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QMGHNDA"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651274" evidence="3">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="26839" checksum="1D2E3DB3678FFD4C" modified="2013-12-11" version="1">MRFNTLLTVALASTASAVKILMAGDSTMAQSSTNIQGWGTPFAQYMNLSVTNLARGGRSARSYTREGLFIALLSQVSAGDYVIIEFGHNDGGSPSTSDRAPTAGTGNETTTVTLSDGTVEVVQTFVTYERNMVKAVLAKGGIPVLASQTPNGDAWNTEKTKISTPPRFVGYAELAAEDEGVAYVDHWNWVAVAYEDLGYDNVYPKLFPNDHTHTSPEGADIVARAFVNGLRCVGHPLANSLTAAGKAIPKVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L444</accession>
    <name>U4L444_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L444"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7302" checksum="CEEC96DD65174840" modified="2013-12-11" version="1">MFRPSPGYAVAQHALQLLSCALPHSQLGGKDTSCHLDFRHGTSHHTNNSCFLNLRLKMYNFNITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L498</accession>
    <name>U4L498_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Transcriptional regulator CRZ1 acc. no. P53968</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L498"/>
    <dbReference type="STRING" id="1076935.U4L498"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="25602" checksum="80B7530EA03CB02D" modified="2013-12-11" version="1">MPRRLPGKIFQYRGNFKAGGTWGCGKIFGRKYALNRHVRSDAGRVCFRPLLDGETAEREPQQRQHTAFPNVIIKKYPALANIAWDTASPEGDYDDNSALEMLENKFKDDLSDAGGIAGGSSGNSFDGGRPGGDRVYDGENRQQGSQQQGAGIGGTVEGEGDTSVTGEAGEDEDGGVDSVPNIFALGNRRIQKDEVGFGGTVEEEGDTSATGVTGADGDEIIASIIKPFGSFGYREQRDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4N2</accession>
    <name>U4L4N2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935346">
        <property type="protein sequence ID" value="CCX07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4N2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="279" mass="32468" checksum="85A63D644444D2C8" modified="2013-12-11" version="1">MPPPAPKLKNHTAYSSPLQFAAWTAIHWIDAGDASVKYPVLRESKLNYLIEAQKAASTSSPWDIIVLALGSSIVGYPRAIWVKFGVQSFATDRLRRYMVGIRGALCTILNEDYYTFRRKFWKHNDWLPATDDDVDAYRRIVITELFRILTFTSPLHRDAPKRRLKLNQCGEIIKYRSDMFQYALWMMVFNICVGILVEHDDAKMDCAVFEEPTLVVLELLNEYGMRVKEWPDKRTRPLKGWLKQNLDTEADKKILREVWLDYGVGIDILDEEDEMPVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5J3</accession>
    <name>U4L5J3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5J3"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3900" checksum="2E81DDCE6B777A9A" modified="2013-12-11" version="1">MCWKVNLTRIEPFYAVKCNGDPKLWREIGQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5R6</accession>
    <name>U4L5R6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5R6"/>
    <dbReference type="OrthoDB" id="5416180at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="437" mass="48406" checksum="4E20AD6D66389385" modified="2013-12-11" version="1">MTSFATAPTPPTARCSSVVANDNSSKLAQLPRFTTSPRKHSSTVPMTSIFGQETPPSSASSKAVIALLGGGGTSLHAVKRKRSKYTLRHDYPNSSHGIISNTSKSTMTPIPAFVAKKISIILDTLKDHEYEHKNAPSSDDSSTRPPLLPFTSQEVNNGNQQGELPLDQLPVWPGSDTLIPPVSPALSESDSPPSQFLDLLGLFETHPIASGIAAHLYGHDLRNLRFLNSDFRDLISLGTSEAGYPLYFKVLLSKTLPCPREGTATEPVGRSCKNTGGNVGPCILCSTIVCSTCVSPEVWTTKRYRYICPRCCASSSDEMCRCQEHPWLCRPCYRKHWIKDLEYNAITWFSAATANCMFCDEKYSCDTDSRLPKNPVNGIREFKKWLKQSRITTTDPRTEGNRRPAGCGWCKKRVHPLREGWSMRPSMVRRDGSLRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L665</accession>
    <name>U4L665_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935256">
        <property type="protein sequence ID" value="CCX05515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L665"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="141" mass="15588" checksum="16124785FBD610C7" modified="2013-12-11" version="1">MGPLSSSTWHDLSCVIGPHCQRCAPALSPSVIQFSASTPPLVSRLSFNSFRCLQQSLEIVERHVCLVNTHRQRFVIRCIRATARTNDVEAPPHTTSTPSFLYFLHANASSTWSSNLGPSFSTILGVWCRVPSLQPLHGRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6S0</accession>
    <name>U4L6S0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative alpha/beta hydrolase R526 acc. no. Q5UQ83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6S0"/>
    <dbReference type="STRING" id="1076935.U4L6S0"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEWDMLM"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="74"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="39788" checksum="4AFBE82762B41B96" modified="2013-12-11" version="1">MPRPRWALSLEANFWRNAMAAGMYLHKCASPVPPEPKFTISIPSTLSKFLGKIPLSFYVPDGYTRTSDTKYPVLVNYHGGGFTLGTASDDARWCATVNTLLNAVVISVDYRLAPEYPFPTAVEDGTDVLLWLHTHATEYAIDPARIGLSGFSAGGNMCFSVPLRLFSLQQPTPRLAAIAAFYPSTDFTSPREARRATNIRPDKELPKVFTDLFDASYLWPPKEVRMENPFLSPAMAGDADIHKALPKNVLIVLCEWDELRAEGERWRDRLTKLGLNVWSELVLGVAHGWDKAPNPVWEDRKAKEVYERVCKQLGKVFYGPDWKLPLDVKVKSELKDIPVVTASTQEKARVKPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7E8</accession>
    <name>U4L7E8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7E8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10722" checksum="2818228F08316BCD" modified="2013-12-11" version="1">MNLVYTCPLRKEEGGCDTFLWKDQAVLREPKELAAENENISTRIERQGMAAAALRRVPPTPTRVPPTPSRRDYQTLPTDPESDSDIEDNSTPPGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8N0</accession>
    <name>U4L8N0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8N0"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15245" checksum="FA510F638A53D9C9" modified="2013-12-11" version="1">MPPRNSPPRNHPPEKNADDEFNVTDNLYDDEINTDRGYLPTSRNPRDRVGPAIIADDDDNDEGMESHSRKENNSDEQLERDEKEVIDQHNILGGVDEPIQTRHASKNYKEPDDNEGLPDIEGTGASNIRGEPDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8X9</accession>
    <name>U4L8X9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8X9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3387" checksum="251CC6D9D5071C6A" modified="2013-12-11" version="1">MSELVLLIQNYCGSYSFAGLKSSDYPRQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9C5</accession>
    <name>U4L9C5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="15" type="ORF">PCON_01286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936124">
        <property type="protein sequence ID" value="CCX15022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9C5"/>
    <dbReference type="STRING" id="1076935.U4L9C5"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHVATKE"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="14">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX15022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="453" mass="50150" checksum="7018855C721FE591" modified="2013-12-11" version="1">MSTINILAPRQKDELHKSILAYLNSNGLPNTCAALREELDAGDDFLDETKLKKYEGLLEKKWTSVVRLQKKIMELESRINSLQTELDSSTPTSLMKKNSDPTAWLPRGPARHKLTSHRLPVTCVAFHPVFSVLASGSEDQMLKIWDWELGELEMTIKGHTKAVLDVDFGGPKNGILLASCSSDLTIKLWDPANDYKNIRTLTGHDHSVSAVRFIPSAAGEYLVSASRDKTLRIWEVATGYCIKTIQGHVDWIRDVTPSFDGRWLLSAGNDQTARLWDTATAEHKATFLGHEHVIECCVIAPPSAYPLLSKIAGLKKPPPSTSSLEFIATGSRDKTIKIWDARGTLLKTLTGHDNWVRGLVFHPGGKYLLSASDDKTIRCWDLEQDCRCVKVISDAHEHFVSCIRWAPAPAKEPLVNGDGKVNGINGAKEQGKVNVRCVIATGSVDYMVRVFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9T2</accession>
    <name>U4L9T2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized peptide chain release factor-like protein YLR281C, mitochondrial acc. no. Q05863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935324">
        <property type="protein sequence ID" value="CCX06944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9T2"/>
    <dbReference type="STRING" id="1076935.U4L9T2"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="33"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="49912" checksum="F099CCA183B2AA8A" modified="2013-12-11" version="1">MTLLRLLNFRRPFSVVAPLRQLPPRPVKPKASHIDESEITEVFLHGSGPGGQKINKTSSAVQLKHIPTGIVVKCQETRSRSQNRKLARELLAERLDQEAHGANSWANWKQEYEANLRARALKKTRRKHNKGKVPIEWETDTKPPREKPVSDKPDIVVEEDIVGEASELPPSQRIKVTSKDVRAMPWDSTFPLIQEVRYEGDINKFPGVKAGLDEELVLRYRGYGGTNYEDLINKTRLEQIAAGRDPTQWQQRTVEKPQYVKKEDGTWALEMTKITEWVDTVWERQHNLQVEAQDKIDAVKEPEREKREAEAAIRKAIKKAEIDEKREQKKKAKELEEQRRQQQSKEAMRNGLPPPGPSNQKSPPRRTITHDRNDRNHRPHGRRNDSQDDHQYNNRQHDEPQRNQRYERPQQDSHPREESSGFKVFRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9T6</accession>
    <name>U4L9T6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_06536</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935328">
        <property type="protein sequence ID" value="CCX06949.1"/>
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</entry>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07892.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="77" mass="8822" checksum="94C3CFC32870AA72" modified="2013-12-11" version="1">MRISLTIILTMFVHAFLQTLLYLPRVQSPFPCKIGSAWFGDPLLPYRRYLSKHPDPSLCVEAQEFSPALLSRVFSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC79</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
    <sequence length="30" mass="3690" checksum="B822CE5A917A11A9" modified="2013-12-11" version="1">MRFLERLDEAKSEYEGIKRRMMRMDTGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCK0</accession>
    <name>U4LCK0_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936491">
        <property type="protein sequence ID" value="CCX16631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCK0"/>
    <dbReference type="OrthoDB" id="5489790at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="239" mass="24871" checksum="01E3DEF60CF5FEBD" modified="2013-12-11" version="1">MLPSSSPNGDKNMIIMPKVNDPVSFYFGDAVPAVPGSGPGTVYFHGIPSASDPNSPHDPTILQPRNGSTSASTHPNDDGNNNITMPKDDDPVPCHLRSAGTTVPGAAPGTVYWHGIPSASDPNLPYDPMTLQPRNGSAQASTAATAATAPGSPASTASSTPWSWRSSSPITDTNPTGSGWSSPATWLSPSPSEPSLSPRERNLAPSGPSFTLKSEIENLSLLDTNTPNPNELHQRLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCL9</accession>
    <name>U4LCL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935358">
        <property type="protein sequence ID" value="CCX29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCL9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5662" checksum="4F3E903E24A0892D" modified="2013-12-11" version="1">MMSLLASPMLKYNPCINPPSPFVNPNRPQSSPADLSIVRQTSTAIDYVFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCP3</accession>
    <name>U4LCP3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCP3"/>
    <dbReference type="STRING" id="1076935.U4LCP3"/>
    <dbReference type="eggNOG" id="ENOG502QVAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX29643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="604" mass="67352" checksum="1EAA8DA029CC69E6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCU2</accession>
    <name>U4LCU2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C7orf50 acc. no. Q9BRJ6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCU2"/>
    <dbReference type="STRING" id="1076935.U4LCU2"/>
    <dbReference type="eggNOG" id="ENOG502S9T9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDRDNWK"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="434" mass="46915" checksum="8BB8F3680260565E" modified="2013-12-11" version="1">MSDSVHVPAWKKIGLKLKNDGAAPSAVTASKKRKHEDDSKAGAVGEKKKEKKEKKDKSEKKEKKEKKEKKDKSEKKEKKDKTEKPDKSTDAAPEVSTPSKPSPIKPILKRQETDSARRKSVIFAPDVKTEDGDSIKQMLIALDPFGKNASKGIVAPANPPAAVAALVAQKNEAASAAAAAVETPATSADPVAPTEKRAERKRDPTAPKGKLSVSKKTIFDEAAPATKEPPKKKVKLDNKPKHRGGSNNDGSSKPYLGYLSNFYLHKNLWKFEKAKQNWILRHVLDLEKIPEENDKALAAYIGGLQGAGAKDLLLKEVMKVLKEKDGEELARAKLVAKALGRRDLADESDSEDSDSSDSDSDSDSDSDSDSSDSDSSDSDSDSDSDSDDDEKPAKKDEISVGEPKAATENKKDESNSDSDDDSSSSDDSDDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCV3</accession>
    <name>U4LCV3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to mRNA export protein mlo3 acc. no. Q09330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCV3"/>
    <dbReference type="STRING" id="1076935.U4LCV3"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="285" mass="29309" checksum="EDD58195DA95FCEE" modified="2013-12-11" version="1">MSANLDHSLDEIIASRPRGAPRRGGKPATASPAGGVRKRSSRVAAQKANVSVAANAAKAAPKSAPTGPSSKSTKIIVSNLPKDVSEHMIKVRRLLEIANAFSVLKEYFQSVVGPIKRALLTYGPDGKSRGVATIEFQKASDATLAASKYNGVDVDNRPMKVELVVDPNAPATFAERVGQPNKLQNNRQKAENNRPKPAAKAAPKPAANARGGRRGPAAAGAAPNQRGAKGGRSGSGRAKPKTAEELDQEMSDYFGGAGDNSATAAPAATNGAATGGDVGMDDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD35</accession>
    <name>U4LD35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Tubulin-specific chaperone D acc. no. Q28205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD35"/>
    <dbReference type="STRING" id="1076935.U4LD35"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPHEAWH"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="339"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="417"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="888"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123962" checksum="6098212125320611" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDR0</accession>
    <name>U4LDR0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935444">
        <property type="protein sequence ID" value="CCX09219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDR0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="14358" checksum="90430082A7A36111" modified="2013-12-11" version="1">MRRIIDKCRYYLSETANDYPCFAPCHECPTFSDFEKASLVECEAQQRRTPTLVPTPNGGRLVIHGLNSTRRRHKYRCHGAGWNINLPSFHCLFKTLYHTNLIFFNTHSSNNGNFPKAVRARNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDY2</accession>
    <name>U4LDY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDY2"/>
    <dbReference type="OrthoDB" id="5209158at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14088" checksum="2AE71C80CC2EDABC" modified="2013-12-11" version="1">MSGATDIGTHEPSTRVAALRDTGFPEPLSEERNTTIPHPDAAPYSELPEALIEEHKRRRLSRMMPGKHRNKSPTDIENEMYSGLETEENYDGQGGVEDWGRTKEKKHRHEGLVKKVLHKLSCGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE49</accession>
    <name>U4LE49_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to UPF0382 membrane protein C1782.12c acc. no. Q9P7G8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_08576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE49"/>
    <dbReference type="eggNOG" id="KOG3472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEYQFYH"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="126" mass="13149" checksum="DBEEAF93520DC8C4" modified="2013-12-11" version="1">MPTSPSLWTIGCLYGASAVAFGAFGAHGLRARIADPARIKSWETAAHYQLIHSVAVLLSSANPVAAGLFTAGMTMFSGSIYAMTLIGPEKLKSTGWGKVLGPMTPVGGVFLIAGWVMLARKGKIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE65</accession>
    <name>U4LE65_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Chaperone protein DnaJ acc. no. B9JZ89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE65"/>
    <dbReference type="STRING" id="1076935.U4LE65"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652189" evidence="3">
        <location>
            <begin position="23"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="489"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="747" mass="84637" checksum="F70D513D68E80E81" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEB6</accession>
    <name>U4LEB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Glutathione S-transferase U1 acc. no. Q9ZW30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEB6"/>
    <dbReference type="STRING" id="1076935.U4LEB6"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWISLEY"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="405"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="641" mass="71066" checksum="FBBABBECD58EE92F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEJ9</accession>
    <name>U4LEJ9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_08758</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEJ9"/>
    <dbReference type="STRING" id="1076935.U4LEJ9"/>
    <dbReference type="eggNOG" id="KOG3791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSTVNNR"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="240"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX30559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="616" mass="66025" checksum="34E57A36141F7ADC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEU8</accession>
    <name>U4LEU8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_12858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935793">
        <property type="protein sequence ID" value="CCX13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEU8"/>
    <dbReference type="STRING" id="1076935.U4LEU8"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="537" mass="58949" checksum="39968F430607E0B2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFG5</accession>
    <name>U4LFG5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_13317</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFG5"/>
    <dbReference type="STRING" id="1076935.U4LFG5"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="36864" checksum="B5FF7D105AA7DBA3" modified="2013-12-11" version="1">MSTQDLITRLDAIAGPYALHTLAFFGAFTLVVGALKYTNAFLSLFILSGTNLRKYGPKGSWAVITGASDGIGKEFAIQLAQKGFNIVLVSRTASKLEALATEISTKFAGIETKTLAMDFAKDNNDDYKRLSELVNGLDVAILINNVGKSHDMPVSFLETTDVEMEDIITINVKGTLKVTKVVAPGMVTRRRGLILTMGSFGGFLPSPLLATYSGSKAFLQHWSTALGSELKPHGVTTQLVIGYLITSAMSKVRKPSMMIPTPKQFVRATLGKIGLKGTAGGMTGTITPFWSHGVMHWAIQELLGVWNGFVLDKNRVMHEDIRKRALRKKEREAAAGKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFH7</accession>
    <name>U4LFH7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFH7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17893" checksum="189BD563866E93DA" modified="2013-12-11" version="1">MSYIRPLEPIEPPTPTWLLGPPNNPYEWRQGPIPTLPPISIPMISGDEGRDLPLLHPPRPPGPPAQNHFITRKQFQSREQNLRDLGLLRNPGELIDEPDTAKLRQAVKRWERCYRPQYNSLSSGQGHSRAQERIAELIIHAIKSYNEVLMVWEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFI5</accession>
    <name>U4LFI5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFI5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="111" mass="13002" checksum="82997462E70A7A4E" modified="2013-12-11" version="1">MYRKMGRVRTKIKYENKICLRDIFESEKYRNKPVEYEYDFGIGYTMQIECVEHQAVEDPESIVLLGGQGGKCGWWEDCGKPSTRSDAITWDKAKVREELDGVEIELLEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFR7</accession>
    <name>U4LFR7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Transmembrane protein 184 homolog C30D11.06c acc. no. Q09906</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFR7"/>
    <dbReference type="STRING" id="1076935.U4LFR7"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TEDECFY"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="711" mass="79991" checksum="279485EC737650E5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGA3</accession>
    <name>U4LGA3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Siderophore iron transporter mirC acc. no. Q870L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX15014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGA3"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWKGKGL"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX15014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="579" mass="62972" checksum="69EEA0153DC28923" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGL9</accession>
    <name>U4LGL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGL9"/>
    <dbReference type="OrthoDB" id="5402392at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="48578" checksum="9C2FB5F9B769B2D3" modified="2013-12-11" version="1">MAPEELPKSPVDATVHRDLAPYIRSPSHTHQTRQLLSAHLASLTSQPRITSASGSTDEFTRFLDLELGRGDGVRRQYLTALRAHAQAQRDHAAAVTVLQAATADDSDDEDGGDSGEGQDEQAWKESYLRTLRIRRAHNRLLILREGVAALSSTVPERDLKSAYTSPAPEAPPSLTTTHQEVTTNSADSDALRLELEKRIVSVASSIGGSPLPKRQGTKMQALQAVLEQLSSWLEKKLSIPEPGEAGDQNISGEQNISARILLAYREYLAARKELLMVVGDTDASPPPLEEEEDMRPLGRLDTTPPEAMPVVLRLLAAAEHLVPLVRSQKALLSAGNQFSGAVAKGRGRVADLLQDGGGLAMEDPVSKAREKGEESVRTMAVAEKQAQGFTEEARKKLEEARKTAEEVDTLCGNKERRSAIPTRGGKKEEEEPKGLWGGLGGNVGVIGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGN2</accession>
    <name>U4LGN2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HF935574">
        <property type="protein sequence ID" value="CCX10899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGN2"/>
    <dbReference type="STRING" id="1076935.U4LGN2"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIGPCGR"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="81"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="540" mass="59099" checksum="1F7C52089BA4BE2B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGN3</accession>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5389" checksum="7782BEA88DB5081A" modified="2013-12-11" version="1">MKPWNFSRLRGFEASVTRILMSQRSQSPRIPKEVQSAASLKLTSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHV5</accession>
    <name>U4LHV5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LHV5"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652040" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="9682" checksum="B9A308DA706A70B3" modified="2013-12-11" version="1">MQFTTLISVLAFSATVFGAAIEKRSGPVGVCPTYREDAHFLLADSSDCTVFYKCDRNGPVKLSCPEGLLYAPQHQWCDFPERSTCKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHX8</accession>
    <name>U4LHX8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_02864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHX8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3616" checksum="472F7F25E6EA8290" modified="2013-12-11" version="1">MEHPLRIRFGIFGCEVISHDGAVKCMCRHCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LID0</accession>
    <name>U4LID0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LID0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="10153" checksum="43D54F247BFD214E" modified="2013-12-11" version="1">MRILLRGKRSKGDFNSRVKEKHDILTTPKTPILLLEHFSSPAEVRSALATYDYFFKLSSFFFHRSMSLRPRTGREFVWEYLISALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LID5</accession>
    <name>U4LID5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_11524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LID5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2501" checksum="F14FC241FEA3D258" modified="2013-12-11" version="1">MKSYTAKTTTQSIWRLKPGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LID7</accession>
    <name>U4LID7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Chitin synthase regulatory factor 4 acc. no. O94614</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LID7"/>
    <dbReference type="STRING" id="1076935.U4LID7"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CCX16484.1"/>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
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            <dbReference type="EMBL" id="CCX12279.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX32078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJP5</accession>
    <name>U4LJP5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to transcription factor Rap1 [Ajellomyces dermatitidis ATCC 18188] acc. no. EGE82813</fullName>
        </submittedName>
    </protein>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="2">CBS 100304</strain>
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        <source>
            <dbReference type="EMBL" id="CCX32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9241" checksum="4ABFE3834A14A6AC" modified="2013-12-11" version="1">MVVITQEGNLSAPLTTGLFHDLSFWVSLTVPGRGKLIEDIKKNGGTVSQAERHATYLLVDDRKPPLPDQLHDPKRFGLLRYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJT5</accession>
    <name>U4LJT5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJT5"/>
    <dbReference type="STRING" id="1076935.U4LJT5"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRTIWPL"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="502" mass="56718" checksum="B4BEC0F5EA391767" modified="2013-12-11" version="1">MAEGHNLIMVSNRLPITIKKKDAGNYQYSMSSGGLVSGLSGMTKTTTFSWFGWPGLELPEGDVPKVEEELKEQYNAVPIWLPDEMADRHYNGFSNSILWPLFHYHPGEISFDENAWVAYRDANRIFAKEVAKSVKDNDLVWVHDYHLMLMPGMLREELGDRVKNVKIGFFLHTPFPSSEIYRILPVRNEILEGVLHCDLLGFHTFDYARHFLSCCSRILGLTTTPNGVEYKGRLRTVGAFPIGIDPEKFAEGLQKPSVQERIAQLEKKFQGVKLIVGVDRLDYIKGVPQKLHALEVFLNEHPEWIGKVVLVQVAVPSRGDVEEYQNLRQVVNELVGRINGRFGSVEFMPIHFMHKSVAFEELIALYAVSDVCLVSSTRDGMNLVSYEYIATQQKRHGTMILSEFTGAAQSLNGSIVVNPWNTEELADAIHEAITLPEDIRRANHEKLYSYVTKYTSAFWGQSFVGQLRNISDDAMKAKGETKKEVQVPLVAPDAVEQQTVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK51</accession>
    <name>U4LK51_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK51"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6132" checksum="70BCB2124F8AA5E8" modified="2013-12-11" version="1">MPGALGLGAGSGRGLNAENPKRQASSVRHTFRCFGRWQILFSFVQMIYAQRFESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK68</accession>
    <name>U4LK68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to 40S ribosomal protein S27 acc. no. Q7RVN2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK68"/>
    <dbReference type="STRING" id="1076935.U4LK68"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERINMPL"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9033" checksum="2D7471BCE626AA63" modified="2013-12-11" version="1">MVLAEDILNPSVAAEARKHKLKTLVPQPDSYFMDVKCPGCFAITTVFSHADSSVICTNCNTVLCQPTGGKARLTEGCSFRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKU0</accession>
    <name>U4LKU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935395">
        <property type="protein sequence ID" value="CCX29980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKU0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="4145" checksum="40D7D3267E481AFC" modified="2013-12-11" version="1">MLLTTAIARWIGMVITLLGRNAILLEEILRWLMYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL07</accession>
    <name>U4LL07_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL07"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4108" checksum="6323DAF3053E4CF8" modified="2013-12-11" version="1">MFYPPSLPHYLHRSPDCLCLLPPSCSQPLAISLVVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLI1</accession>
    <name>U4LLI1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLI1"/>
    <dbReference type="STRING" id="1076935.U4LLI1"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FIAERHE"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="260"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="616"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="742" mass="85234" checksum="DF6E7DB54B8E9FF9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMN2</accession>
    <name>U4LMN2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_14248</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMN2"/>
    <dbReference type="STRING" id="1076935.U4LMN2"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="45"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="385" mass="42463" checksum="28918F14E072C92E" modified="2013-12-11" version="1">MASPLRLFRSAPRIANLTCYQRRHVSAFGYTQAKALVYSAYGEPSTVLKLHSHSLRPAYDEEILIKFLASPINPADINQIEGVYPAKPELTIALGTPEKSAVGGNEGVVEVVSVGANVKGYKPGDRAIMKHTSFGTWRTHALAKDENLLRIPDEFKDISPLSAATISVNPCTAYRMLKDFADLEEGDWFIQNGANSGVGRAAIQLGKIWGLKSVNVIRERPDVDALKKELMDLGADIVVTDAELQSRGFYWEMQEKTQGKGIKLGLNCVGGKATHYLIKCLGEGGHVVTYGAMSKQPLNLNASSLIFKDIHAHGFWVSRWSDRNPEAKAEMVAEIFRFIQQGKFKEVPFEKTIWNSDSTEEQLVGAVAKSGQAFGNKKQVFVFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNF0</accession>
    <name>U4LNF0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein ERD1 homolog 2 acc. no. Q10151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_14158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936022">
        <property type="protein sequence ID" value="CCX33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNF0"/>
    <dbReference type="STRING" id="1076935.U4LNF0"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRRWIWI"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="182"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="396" mass="45735" checksum="B370A1445B4091A4" modified="2013-12-11" version="1">MEEEKVAYESISLWLPLPYRVLLLFIIGLWLFSLNLHLFHSVQIDISPFLRYTRSSTESPLHHSVYLFAGILSTIFSLNLLLFWSLTHQSPDLVRQWQILPISLYSIFLLVFLWPTSFLRRGRLRFLRTLRRILIGGIDRDTRFADVLLADALTSYSKVLSDFATVLCMFFSGYSATDPIPDRSCGGAFLVPCVISIPYLIRFRQCITEYQRGAGKMQLLNALKYASAFPVIILGALEKNYMMQEYVTRRELAAGWYIAVVCNSGFAFWWDVSMDWNLSIFSGGSNAEDGPKPWGLRKRLHYKDKGFYYTAILLDLVMRCAWSVKLSVHLDFLNEMEGGIFMLELLEVCRRWVWVFFRVEKEWVAREGGGYEMVNIEEGVGKVEGHVGVNKEARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNS9</accession>
    <name>U4LNS9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNS9"/>
    <dbReference type="STRING" id="1076935.U4LNS9"/>
    <dbReference type="eggNOG" id="ENOG502RBCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FPLYVCI"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36000" checksum="6094221BB5CC0CC8" modified="2013-12-11" version="1">MSSQSDDSLPESETLSLCSTYKETIEIGGRVYQQLALEQEITFTPVDEIERESLDKQHRIFQYIFDERLIFPPIENPERILDCGYGSAAWAFDVAEKYPDCQVIGIDITPHMKPEEMPRNLWLQIDDLNEPFTFQDKFDLVHSRNVAQGIDKGRWRSYIGDCARVVKPGGWLQFIEPYHVVQSDNGTLTDDHAVRQFSMQYSDVLEGKKDVRAAMHLEAWFREAGLVDVEYTMIPIPLNAWSTNPRDRHIGELANGAYKEAIGSHCIYLFQEYLSMTTDEIHVLLARARQDADNPSLRPYIPMYVCVGRKPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ12</accession>
    <name>U4LQ12_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936546">
        <property type="protein sequence ID" value="CCX16981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ12"/>
    <dbReference type="STRING" id="1076935.U4LQ12"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="361" mass="41365" checksum="7CFBF12FDABD52AB" modified="2013-12-11" version="1">MIPTTDPTQVRRGANGSEESEENKDEHSEEDEEDEEDEEDEEDEEDEEDEEGEEDEEDEEDEEGEEDEEDEEDEEGEEDEEDEEDEAVSTAKPEEVRERLGVTHEVFKGYCEWVLPRTRWLVLPNEGNTKYPLEWKLSNEELLSTEIKHKMQDWGIECDPSFLLIALINACRTLYNCKIEAPPKVGDQKATLMWNLMKISNEPSKKAVARSAIRVYKHYRKFKFPNVNALKEKGKMVKRLKRTLDYPFDLDDRFYVWMLYYTANLQRKSIAKKRQAAGKEQAAGKEQAAGKEQAAGKKQAEGLLSAGRSTKRKQSAGLLSAGRSTTRKRLKLGEQSGEGEGGEGVHIHFISYDPLSVQPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ24</accession>
    <name>U4LQ24_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ24"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="26" mass="2801" checksum="7DB281A4B59ABD0E" modified="2013-12-11" version="1">MSEASMEIDPRGLEETASSLASRECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ65</accession>
    <name>U4LQ65_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Oxysterol-binding protein-like protein OBPa acc. no. Q9UW25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ65"/>
    <dbReference type="STRING" id="1076935.U4LQ65"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHTHKKD"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="49520" checksum="1F785682B4BE1210" modified="2013-12-11" version="1">MISGNKSDADGTTAGVKEEEETVVDENEKSMLMSIISQLRPGADLSRITLPTFILEPRSMLERITNFMQHPETLLPMSKVDDPEKRFISVVKFYLSGWHIKPAGVKKPLNPILGEWFTCHWDFVDAPGTQAFYISEQTSHHPPKSSYFYMSPHHHIRIDGTLKPQSRFLGNSAASMMNTSIVVLRLMNRGATAGKQGGGEKYILTQPNMYVRGILFGKMKYELGDHSYVRCSELDLVADIEFKVKGFFTGGYNVIGGVIKRESTGEVLYEISGSWNGEMHITDKKTGHRELLFDATYARPTPPSVRPITQQEPRESQRLWKQVVAALKERNQETATDEKFKIEDRQREEARAREADGVEWVPRYFRPVDLARGEEEQLDFVLNTNIDETASAQDQIRQILGIAPIVAGQSRRPSTYEIPPHAGKSTIDDHDEFVDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR34</accession>
    <name>U4LR34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR34"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2750" checksum="C6628F6E9CB1A945" modified="2013-12-11" version="1">MEMQKPDLKPHFRLQASALVSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR66</accession>
    <name>U4LR66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1 acc. no. O13826</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR66"/>
    <dbReference type="STRING" id="1076935.U4LR66"/>
    <dbReference type="eggNOG" id="ENOG502SDJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32445" checksum="920DD90624846648" modified="2013-12-11" version="1">MSGPPIIDLTGSSPPPRPSRRPAPHEIIDIDDLPDPLPARNAAGDEVQLLYSRPGPQRRGRFNNRELPRPPGSLASFGSLFAAPRSRAMPEDPILGNGSRIGQRSEDMGVNRNHYYPAPPPPPPHQNNYHQRAPTSGSRMYINVGVGGMAMGFGGVISMHNFRAPGLMDYSQQAPGIFEPQTAPGEAARRRQAEYKKPPPPRAGFTRSPKETDILVCAQCDQELGVECVEDPKASEVWTGKCGHCYCGRCAMIFRGLVGGPIQEVGKKRPRPKSGKKICVISGCSNVLTAKMGMIKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRB1</accession>
    <name>U4LRB1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_03759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRB1"/>
    <dbReference type="STRING" id="1076935.U4LRB1"/>
    <dbReference type="eggNOG" id="KOG3372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWDDGHG"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23807" checksum="3CF325CB850BBDE6" modified="2013-12-11" version="1">MHSTSVRVQNVFGFFTTVAFVVAFLTALTAVLYPATPTATVDVVSLKVIKGRPQYYSSKQQEYSFIDFDLEADLDSLYNWNTKQVFCWLSVVYGGAKGSKHTENEVIIWDAILPSKRTSRLHLRNERAKYQINDISGRFLERNATVRFGWNVQPHVGALTWGTVEADNVVEEVDLEKAKGKRRGEGWSFTFPPVGGRKKTPVAEKTKANVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS80</accession>
    <name>U4LS80_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Ubiquitin-conjugating enzyme E2 8 acc. no. Q9P7R4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935728">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UQ_con"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13565" checksum="9C4507225EBFC5EE" modified="2013-12-11" version="1">MNRIFHPNIDELSGSVCLDVINQTWSPMYDMINIFEVFLPQLLRYPNPTDPLNGEAAALLMREPSLYETKVREYVQRYANSDTTANEGDGEDDEDEMSDAGSYDEDDDEEEEATGKMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSC3</accession>
    <name>U4LSC3_PYROM</name>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSC3"/>
    <dbReference type="OrthoDB" id="10398877at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="394" mass="43465" checksum="1FB3E7D8B98DB5BA" modified="2013-12-11" version="1">MHLHSFSRKCSHYHEIKKLKRGCGKIYRAIGGFLHTYGCVTREHQFIDDYGTVQTRYYVTRAEYKADKARDFGRSNATPIHEVAEALTPPPPAEEVVIHRSLQSYRQAQAATAALKLKLESRSSTESHPEAHSDSCYDSGHDSSRSTLASHSRQPSPGPGAAPTETEFETYSRVKRYLESQSRLGADSQTSSPHEGAPALHHEGYNEPPQLDSGYNSSATSEAGDSRIPSSCLEVNQLGVLHSNERHEIESQLDSGYSSPVFREAGDSEEASPRFDAQQLSLRLSNELESHGKVVQHDSGYNSVTSSEVGHSRVSSPCFEEHQLCLHPSDEIHHEAPQLDSGHNSPAPSLSSESHKELPVIDSIDIPYSIHRYICYAARRGAFSGGYSIRPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSD9</accession>
    <name>U4LSD9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PCON_04393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LSD9"/>
    <dbReference type="eggNOG" id="ENOG502SA4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERKERWA"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="33780" checksum="711632611550C3A8" modified="2013-12-11" version="1">MSHAEWLALNGGKLLGTNVKPPETPEEIAAWIAERKKKFPSAARRAQAEKEDAERKERWAKMAGEKKEAELREREKQLEARERQLKEKEESLKRKREEADDGNEDRELEDGEDEDDDEPPEEASAKERTVVRDDRKAGEAQQKKKRKACRSWEKTGECGRGEACSFWHDEKKKGKGRDKREKTQQKPKEEVNRVSLYQRLVEREMDSQNETLLQVIKYLVETGVLKPEEAPKDIVNDDEEEDVIEAASALVQELDDDAEDIVDATEAVTVVEAIDAGEPMDLEAKAALELAKAGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSK8</accession>
    <name>U4LSK8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSK8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17423" checksum="1F0EFB3AE9AC3BFB" modified="2013-12-11" version="1">MADPLSVSANVAGLIGLANEVGKIPVNYASNVKSAHEDAHCLQKELTALCHVLEQMRSLLREEKLQGTRFEETAALVSVLGFTNHQVNELYKKLDKLSIQANKNKLADFWERIRWPLKKDECDKAMEEMRRLAQYFQFSLTAANRLDFLSQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSW0</accession>
    <name>U4LSW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSW0"/>
    <dbReference type="OrthoDB" id="5331246at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="194" mass="21816" checksum="B1BE1C5D2839F1AD" modified="2013-12-11" version="1">MSKTRQIDGPSVPKPLKPNSHHPAHRIFKHQGSKQRKRPTSFTTPENKKAANKKRLPDHPLVNDFNNSLNRSTSSITAKLASTLQDSHQIRISRFAAATAQSQSYIDNARELTGNLGATPILSEESDKQVQEFNNFVDQKKIRIRALWDEWESITKEIIGIRSQVIAINPLRNTDQKGDHGDDEDGDEDDGEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU78</accession>
    <name>U4LU78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Dual specificity protein phosphatase PPS1 acc. no. P38148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936097">
        <property type="protein sequence ID" value="CCX33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU78"/>
    <dbReference type="STRING" id="1076935.U4LU78"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKPYSRQ"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000110">
        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="525"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="593"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="703" mass="79490" checksum="E97869CA7E2D36DE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVK2</accession>
    <name>U4LVK2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_13456</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVK2"/>
    <dbReference type="STRING" id="1076935.U4LVK2"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX32616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="15004" checksum="26A0D81DF3414EFA" modified="2013-12-11" version="1">MSGGKGKSHGGKAGHKVGAEGRTQVSHSAKAGLQFPCGRVKRFLKNNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKNANKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVQ7</accession>
    <name>U4LVQ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein ybiU acc. no. P75791</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVQ7"/>
    <dbReference type="STRING" id="1076935.U4LVQ7"/>
    <dbReference type="eggNOG" id="ENOG502QUAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KLSMAYV"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="491" mass="54184" checksum="F57C7606033D73C1" modified="2013-12-11" version="1">MLQTLQRILSRRARTSVQSASRPIATTSLHVPTPPPPPPPLPRSRPVGDISSIFPSLSGRAASTLPARFAEIKQSIISGHEPSLQASWNRLLPVLRNEVDKIVAHGPSIIPSIPFSSLSSITPAQLASIRQRGCVVVRDVLPKDVALELKHQAQTYVSLNRARVRAFPADDPAVYELYWSPPQVAARSHPNVLATQKFLQSLWHSSDQRAPLATDIPVTYADRFRIRHPGDAKFALGPHVDGGSLERWEDPEYRAVYNRIFSGDWERYDPYDAAHRVTANMDLYEGPGACSMFRMFQGWLSLSSTAPGEGTLRLLPAIRESTAYFLLRPFFENGRLQLPPTTTLHGAAIAAAQEFTTELHPELRLDQSMVSIPKVEPGDYVAWHCDMLHSVDKEHHGESDSSVFYIPATPLSEGNVRALVHQRDAATSGIPPPDFPGHGEGERGFVGGINWNVEGTREMGMGSKGWKVEEGMSVGAKRIVQMANKELGFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW47</accession>
    <name>U4LW47_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_14206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW47"/>
    <dbReference type="STRING" id="1076935.U4LW47"/>
    <dbReference type="eggNOG" id="ENOG502SRV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMIGHEM"/>
    <dbReference type="OrthoDB" id="5378430at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="733" mass="80682" checksum="FD7816CBF9E2EF03" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXI0</accession>
    <name>U4LXI0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXI0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="3985" checksum="0C4350548A768596" modified="2013-12-11" version="1">MEIASPASMTLLQTSASPMNITSPSTIVYHFCGRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYI7</accession>
    <name>U4LYI7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYI7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="10529" checksum="B081BD7ACD30A33A" modified="2013-12-11" version="1">MPSKPNKPSQPSKDQLHNLAHDCERDLNSSEAQNSSRDNISDSKTSSGFDKSTADKHAGSGSHKHGSEPGGRRAPEDEGAGSKRSGRFPKGEVNDWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU21</accession>
    <name>U4KU21_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU21"/>
    <dbReference type="STRING" id="1076935.U4KU21"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWERNDQ"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57658" checksum="46E7BAF99BC37E31" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUL3</accession>
    <name>U4KUL3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Metacaspase-1 acc. no. O74477</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935203">
        <property type="protein sequence ID" value="CCX04421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUL3"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5099668at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="6858" checksum="28B6194B680947C5" modified="2013-12-11" version="1">MAQLQPTRKNILSAMKWLVDDAQPNDSLFLFYSGHGSQVIDRDGDQVHGKDEAICPLDTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUU6</accession>
    <name>U4KUU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUU6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="194" mass="21811" checksum="775BEE6723130120" modified="2013-12-11" version="1">MNKKEVKPEKGEPSASEELAKFLKASIKKYLEEFGGSNQAIPIVVIPMKHSLRLYRNFLHLTIVSSSCRQTWKQSHSGLRNNTQKLWIPQGSNATLFRLSGKKASVTTPLYTLAISRLLIPKLLPRTSCLDQHLRIETQARPENPNPPTQKNHSKTSSSISKEQVLLRDPRALSAFDPTCLYVVNRYALGPGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV10</accession>
    <name>U4KV10_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized membrane protein YDL133W acc. no. Q12516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935244">
        <property type="protein sequence ID" value="CCX05298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV10"/>
    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EHEWTIT"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="718" mass="78512" checksum="5AB58D5ECAC04246" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX66</accession>
    <name>U4KX66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SAGA-associated factor 73 acc. no. O94397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935286">
        <property type="protein sequence ID" value="CCX06366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX66"/>
    <dbReference type="STRING" id="1076935.U4KX66"/>
    <dbReference type="eggNOG" id="KOG4140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GNWMDGS"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="212"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="392" mass="42437" checksum="B4B84939D396F13F" modified="2013-12-11" version="1">MTLSGSSKNNDVMGAFKDSELGGTIKLKNATIRNGKKPTSNWKERAKQLEEKEKEATSSPSRSPGPVVTQLDDKDVATFATGRPLQDDPDYKVCKHCKKPVLKTVAAEHVRACYKAKTERNKERKKQREEAAAVAAGKGKEDDTKSKAEEDKEVKEKDEPSAEAKKKVTGAKKMAKKDTESGAKGKKRKADTAATPKEPKAKKKKEKPAKPEPKPKAPVDVERQCGVQLPNGALCARSLTCKSHSMGSKRGVLGRSQPYDVLLAAYQKKNQAKQQKAAINAGGPPPEEIEANALPVDSDEETELVMTAITTHAPQPFEHHIVVPLRKKAQYIRMRDAMASALRPVGTPHPLSATGMPDGILGGAFGRGPPPKAFQPPPPPIQRKSSINMTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXN5</accession>
    <name>U4KXN5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935198">
        <property type="protein sequence ID" value="CCX04309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXN5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20880" checksum="F7EC2925702E377C" modified="2013-12-11" version="1">MSRQQTDSGAGNPPNSNPDPFTSALQSGQPPTTPPDQPPRPTNSNIGQQSAGNAQAAQIPQPVPFWEQDFETEEEFQRAALMDRIGKDARSFLMYMPRMREQEATATKFAQWLVSVKGTPENLGIDDVGKMFRIWKSAASRCTCNTENQRALCEHQRICRRQMLNQYTASLPPQPQQPQQPPPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXY9</accession>
    <name>U4KXY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin-2 acc. no. Q01484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXY9"/>
    <dbReference type="STRING" id="1076935.U4KXY9"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="484" mass="53444" checksum="0E5419D759B6B577" modified="2013-12-11" version="1">MPYKSEHSFDPEDLPPIARINPAGKNMQLSAYPTAGYTNTETSPCNVPQDQATLFRLPIELILLIGEESNDCTVASLRLTCRFFNDILTPLFYKGVIKAFSLPANVQSGGRIFKLFLLAVKRDDIETLETLLQYGLKLDTRLRYYQSLLAFTLGEMRGPGAPGLPMKMLKLLIGKSEIDAMEFTAAVRSGFIEPVQMMIERVSPDTICEFITENKNILSDGIFRGGQSAACINLLLEHGALKSLNQPGDDGYTPLLKSLIFQEDANLAMILLEKGAVPYITVPFRTVTALHVAAGFLFGPIRRYENVVREPAGFTSLDVVKKILDSEYKDTLLDAVDRRGETPLMYAIRASKLETVKVLLQHKASPNIANADGLTPLKLAIDMANPTLVELLLEHGANLLLAHGACTRVKDAKGNSVLHLTLNRFESGSRVVLLEPLIRHGAEVDWPNQAGMKPLEMAKNRQIQKAVKILSTHGANEKATRYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYB8</accession>
    <name>U4KYB8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935343">
        <property type="protein sequence ID" value="CCX07217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYB8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="33" mass="3766" checksum="508FC47F9D2F40C8" modified="2013-12-11" version="1">MHYAHKMSPNPDPIEIQNLEVRTGDLSNLLQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZH4</accession>
    <name>U4KZH4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein RBE_0317 acc. no. Q1RJR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZH4"/>
    <dbReference type="STRING" id="1076935.U4KZH4"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="13118" checksum="72AC5CA96696073D" modified="2013-12-11" version="1">MLACQSGNLTIVEELLEREDTDVNLTDNLGWNAFFYAIQARQYVIAKLLLKRKDIDVNIKDKNGTSALQLALNHEATSIVTMLLARDDFKFKTEDPIANNEHLSPIPEEEMPGQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZJ0</accession>
    <name>U4KZJ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5166" checksum="D98FA157ACB2AB7F" modified="2013-12-11" version="1">MVLTVCVTKSHGISLYTLIHRCVGRLVMLMVLSYSYRFTSRSNDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0I8</accession>
    <name>U4L0I8_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935426">
        <property type="protein sequence ID" value="CCX08623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0I8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="23074" checksum="1C24E3543CCBE541" modified="2013-12-11" version="1">MAKSLCVTVSGINVYVNPTATATNNNSHNAFGEKNIYVNPVAAQTLQNEEQVIAAWVEPCFSGLSLRSSRYNDGECFLSFRLLAQAMLMASKLTKDVSADSTATTAKYCQYNGEWKILYIFAGVQGWDCNKTKPKEIKITGTKNDVRNMIESIFGAQGCRQDELEFQTVDGMLDVWARPDMERLNRGDLMVALAMPHIENGEVQNGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0S6</accession>
    <name>U4L0S6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935444">
        <property type="protein sequence ID" value="CCX09217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0S6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="7991" checksum="1A6F1C5A9B005A3E" modified="2013-12-11" version="1">MKKIGAMVMFTADAGTEGYGLAMFTCVLEMSTEDSLEVCRKASAEIENKNHHVWEPFHVAYGRKPSNAPKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L109</accession>
    <name>U4L109_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative uracil phosphoribosyltransferase urg2 acc. no. Q9US43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935419">
        <property type="protein sequence ID" value="CCX08562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L109"/>
    <dbReference type="STRING" id="1076935.U4L109"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="155"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="382"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="603" mass="65116" checksum="730E4268E4FF79F4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1D5</accession>
    <name>U4L1D5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to WD repeat-containing protein 7 acc. no. Q9Y4E6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07870</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4L1D5"/>
    <dbReference type="STRING" id="1076935.U4L1D5"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFHRPTQ"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1145" mass="124062" checksum="C56BBF02FF12623C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1M0</accession>
    <name>U4L1M0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial acc. no. P22142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_05705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1M0"/>
    <dbReference type="STRING" id="1076935.U4L1M0"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="7">
        <location>
            <begin position="188"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX06118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="51728" checksum="14925CE9D08513BE" modified="2013-12-11" version="1">MVLPFVRLASRSSAKFLPRFAAAPSAARRFTTSPIQKAQPEYQRTTLTEDAPRSWGAQADAPTELKPENRKIRHYTVNFGPQHPAAHGVLRLILELKGEEILRSDPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMTNEQCFALAVEKLLNIEIPDRAKYIRTMFGEITRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVHQDLPLGLLDDIYQWATQFGDRIDEVEELLTDNRIWVGRTKGVGVVTAAEALNYGFTGVMLRGSGIAWDIRKSSPYDAYDKVEFDVPVGVNGDCYDRYLCRMEEFRQSLRIIHQCLNQMPAGPIRVEDYKISPPPRAAMKENMEALIHHFLLYTKGYAVPPGETYSAIEAPKGEMGVFLVSDGSERPYRCKIRAPGFAHLGCFDQVAKGHMLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L215</accession>
    <name>U4L215_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ribosomal protein S16, mitochondrial acc. no. P08580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935436">
        <property type="protein sequence ID" value="CCX08896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L215"/>
    <dbReference type="STRING" id="1076935.U4L215"/>
    <dbReference type="eggNOG" id="KOG3419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="123" mass="13681" checksum="30FA4CE3B3DA5B9F" modified="2013-12-11" version="1">MVVRLRLARFGKRHAPIYNIVVQHARTARNARPIEVIGTYDPIPKPAPEGDGKPIKDIQLDTVRAKYWLGVGAQPSDPVWRLLAMFGMIEPKWQVQRAKALHGAEAMKPKVPRAAAKKADAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2X7</accession>
    <name>U4L2X7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935302">
        <property type="protein sequence ID" value="CCX06608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2X7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8865" checksum="DEE505C9E3CF214B" modified="2013-12-11" version="1">MVDLVYVQIKSGSEVLRGNVSTVTAYKTDVVNFLMIWIAVKELICLLLLIGNIMSYRQYIAVRHRVISVIIGRVLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4R9</accession>
    <name>U4L4R9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized membrane protein C6F6.13c acc. no. O14244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4R9"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEVGWEV"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="658"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116142" checksum="018FC5A781B987D6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L509</accession>
    <name>U4L509_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L509"/>
    <dbReference type="OrthoDB" id="10467850at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="18106" checksum="A9BF3AD3282E7CD4" modified="2013-12-11" version="1">MPVLPRALVFLGALITLTTTTYLIRPIRPWETPFPSQHVPPPRPRGESAKTNIPLPFRKRRELILNGNEDVKRFLKRVDVLWWLELHFGPWRPVNHRDPRVNLRVMDISAVMETSQPWWMNRRERRRREKEEAAEEKRVNDPTEEMGDVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L530</accession>
    <name>U4L530_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to DNA polymerase delta subunit 4 acc. no. O59835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L530"/>
    <dbReference type="STRING" id="1076935.U4L530"/>
    <dbReference type="eggNOG" id="ENOG502SC9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYGPCTG"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="201" mass="22287" checksum="D0A81DD67B218628" modified="2013-12-11" version="1">MPPKRTATKPARQSTLSFNTKVTKPARSPSKKLNGKHEGVKATKSRTVTADIFRDSQDSDVVKIEPPKTSPKKVEVTKKDARELKTPAKEDKLMAEKQEEDKIEAPKISQAKIKAYYTAILSSRLVAPVHQSDLSTTEKILRHFDLSSQYGPCIGISRVARWRRAEVLGLKPPMEVLAVALEKDAETMAEIDGFFEGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L546</accession>
    <name>U4L546_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L546"/>
    <dbReference type="STRING" id="1076935.U4L546"/>
    <dbReference type="eggNOG" id="ENOG502S19W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DSARIWA"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1012" mass="117540" checksum="849C3C16B9993713" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L561</accession>
    <name>U4L561_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L561"/>
    <dbReference type="OrthoDB" id="10426680at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="406" mass="46569" checksum="96064C1D64F558B1" modified="2013-12-11" version="1">MVSDTNSQALTAPDLDVSTSVSLVQCPSAKAPSANISAATILTESSPQSPTITPHKEVIAQDPASYLGLVELSQRLQEAVAASEQEKSMLKDKNYQLQLQIKEESDFETRYKILEEENTRLKAELENAFQYGPSDLTKDMTRLLRKNDELEERVAKQTDYFEKHLAENKKQLQEYIGQQLAENARLLKRNDELEERLIGNKKEMQEYIQQRLAEVMQKTENYSEETTMSPKSVDAKIENMEQKMETYSQETTKSLQSVDTRIEKMEQKLDQKIASLNGYNLDLIKAKVLELDKILLPTEFHQLSYFSRPTQMVPTPEGVIKVSRHISGPYIYINRAEMINHDFQDFLFIPMCVWGVDLSRVKTILIVGRGRITTGDWHKFVPRIAVINLKLLPSPFDWEVSCILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5A3</accession>
    <name>U4L5A3_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4582" checksum="89CF67090DE18E0E" modified="2013-12-11" version="1">MPRRVISRNSNVFSNRAERRHMCSSSRQVTQMHEAEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5T5</accession>
    <name>U4L5T5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized RNA-binding protein C126.11c acc. no. O94403</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_11251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5T5"/>
    <dbReference type="STRING" id="1076935.U4L5T5"/>
    <dbReference type="eggNOG" id="ENOG502SBWH">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="208"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="342" mass="39027" checksum="006CE42D226C7574" modified="2013-12-11" version="1">MAPTSLRDEITLDDILARERHARASKLASEILGKARFDKDGKPKRLSSIGSIVKPTSIPGISFSNATARALQGNKLFEALHPEYRHIISLLPPPRENQDHQDYHDYRDHRGDHYVGRRNRDYRGDRYVGTGNRDNRDHRDSRDYRDNKVQRDNREHQDNSDSRDSMDNKNNWENRENIFENTPRVKIRGVSREDEINIKGVAVPTQPVIQASNFAPGTTQEDIKHAMMAYGTVLSCLILTTEPVIVVELILETIEQCQRIVEKFNGVTADGKKLSVSFKTTPAVGLMNLQDRKPILDPYAERAEVDRQRRVENMSYTDGSYGMAAPPIYSDALLRKGRGFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L649</accession>
    <name>U4L649_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF935382">
        <property type="protein sequence ID" value="CCX07916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L649"/>
    <dbReference type="STRING" id="1076935.U4L649"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="399"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="723"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="765"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="807"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="898"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX07916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="967" mass="108271" checksum="6AADA29505861DBA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6K9</accession>
    <name>U4L6K9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_11709</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6K9"/>
    <dbReference type="STRING" id="1076935.U4L6K9"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGCAVEL"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="148"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="34965" checksum="57224A378F862146" modified="2013-12-11" version="1">MVKAAVLGAAGGIGQPLSLLLKISPLVDELSLYDVVNSPGVAADLSHIATPAETKGFLAADDGLEKALTGCDIVVIPAGIPRKPGMTRQDLFTINAGIVRTLIQGVAKFCPKAYVLIISNPVNSTVPIAVETLKEAGVFDAKKVFGVTTLDVVRASTFTAAVTGEVDPRKITIPVVGGHSGETIVPLLSAATPAVSIPEDKYAALIKRIQFGGDEVVQAKAGAGSATLSMAYAGFRFAEAVLKAHKGEKNIVEPAFVYLPGVPGGQEVQAAIGGQLEYFAVPIELGTEGVAKATNPIPNVTEAEKKLLEVAYTGLADNIKNGIAFAQEKAVAEKEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6S8</accession>
    <name>U4L6S8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13319" checksum="936B693FD13A6FE0" modified="2013-12-11" version="1">MTSDTIINTTVEDIATDTAGLSNPFSTDTIQNSTLTNTGGPEARTKELAPGVDAKPEDLNTRPESEQLNNNSGSNEDEAEHQDIVVDELQELKEVQELTEWLDTELGWDNNTGVYEGLPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6W4</accession>
    <name>U4L6W4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935781">
        <property type="protein sequence ID" value="CCX13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10510254at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="44464" checksum="712C41F4A540448B" modified="2013-12-11" version="1">MATPDAYYAELAAKKRADAQGQVQQSATSPYGGQQSLSPAPYGQPGRSPSPAPVYGGNGGSGSYGGGYPGQGGYGAGAQGGYGGNGGYGQQQTYAPSPPMYQSPQFPASPVYSPQPGMERGMGGPMGYEKPPLSAEEYVNQSPHLQQQAAHRRGEASEYLSSVDGSVAGYTPTTSTSGFSYPGEDDRQLTYPGGPGYPEHDGGVSLGPDGPTGERGLAATLVGAAGGAYLGKQAGHGVLGALTGAVAANVIEHKMKKKKEKKSSSGDKEKKKKKEKKEKGDGHHHHHHHHSHGDKKDKKDKKYKEDKKRRKEEKRRRKERELAPPVYVQGHSYSTGGGSTFSSLHTPSVVYSDDERSVYSSSRGHREFREGHKHRHRSMKGHEKRHRKRSSSSSSSSSSSSSSSSSSSSDSSSSSSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6Y4</accession>
    <name>U4L6Y4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6Y4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4916" checksum="9F04BEE5EB484DC5" modified="2013-12-11" version="1">MLRLSFKIMTYPIRLFGKMLETLEAFFWNGQSNHAKQVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L724</accession>
    <name>U4L724_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935693">
        <property type="protein sequence ID" value="CCX12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9111" checksum="4F2F61ECE73AC4C8" modified="2013-12-11" version="1">METVVSSIAAVDQDPLYPSPAWIYRYLSYPSAFSKPCLSFQRSSTLHHTSCCQLAHIMPQPFSFYTRPALQLTQPSGSRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L747</accession>
    <name>U4L747_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="30468" checksum="3D0E20D907F8429F" modified="2013-12-11" version="1">MASDKEQSPAPAEAGASTSSAPATASNTPEPTSSDPVKARMDRWKALQNRAKKSSATNLQEVYAERRRQAIDPSTTSKLERKKATAEFKLAKAEASEAGEDFERKRAWDWTVEEAERWDRRQEKKRRHVADVAFQDYTQTARKMYKKQMRELAPDVEGYAAEKAKLLKDGSVVETEDGELVVVDRDGAFYADADSLAFVENKPKKEAVDRLVADLRKAEDARMARKRGGEDEDVTYINDKNKNFNQKLARAYGKYTKEIRDSFERGTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7A7</accession>
    <name>U4L7A7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_12072</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935704">
        <property type="protein sequence ID" value="CCX12478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7A7"/>
    <dbReference type="STRING" id="1076935.U4L7A7"/>
    <dbReference type="eggNOG" id="KOG0995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSHKFQK"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="102"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="370"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="553"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX12478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="683" mass="76934" checksum="EB85613AF5C519D7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8B4</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_09211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX09618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="352" mass="38051" checksum="957403FB3D34086F" modified="2013-12-11" version="1">MRLPFPRPSTVVGQASRKLKIIPYLIILSFLLASIIINAIMVNGCKLPSPVMRGFYLISITYNPDSQLAKLGESIASSKSEIKGKAKDIGNAITSKVSGKKAEEEVPESQDRFLASVRVGYSALCIQSKGAKDKDLSWACGKQAVADQKFQGDIMQLALVGKLIEKMSWSPIIWAVMGSLIVGWIMSLLGLINSVMPLMFKFTEKIWFQNVNFYCIAGGTLGWLGAMLLQHAMGSMVQKVIELVGNIGDGAIVVKRGSQMIVFGWIQLGLLVAATVLMCWVWCMGFSERTTVDAESAMVDRAMSAKDEMMEKAGGSLPGSLRGVDAAKLKDGKSMVNGLVRAGGAFLGRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8B9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_13260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8B9"/>
    <dbReference type="STRING" id="1076935.U4L8B9"/>
    <dbReference type="eggNOG" id="ENOG502SBHE">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="16313" checksum="C6B36E36C5C0F153" modified="2013-12-11" version="1">MSADSTPTGSPQMTPSSSIYTPSDLSFSQASFLDAPTPAMSDLGHQEHNHDHDHGNLQHADTESLTGTETDDEAEQEWQESLQQLNLLVSLVVLPFFGKWVGRRCAYWAWTKFMTWKHPTMEVVVKSKAAWNAAGVVGALSGSRALPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9J5</accession>
    <name>U4L9J5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9J5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4796" checksum="6D69527A22BB2355" modified="2013-12-11" version="1">MYYPKGTKLISILNGNFRYRSLVPTRARYQVSEASDLASELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9P9</accession>
    <name>U4L9P9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7824" checksum="E5D9B059B04D37F1" modified="2013-12-11" version="1">MMAHVHVRLLEESNEDDDDRSEIKKEVEEEYEEEHHAEDGRMSKKRWNGMHRMQMGKGSSEDVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9S2</accession>
    <name>U4L9S2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_10061</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9S2"/>
    <dbReference type="STRING" id="1076935.U4L9S2"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TVHQPLW"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651795" description="alpha-glucosidase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="15">
        <location>
            <begin position="92"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="14">
        <location>
            <begin position="378"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="16">
        <location>
            <begin position="716"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX10467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="951" mass="108547" checksum="71D86A2E7A36A7B7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9W7</accession>
    <name>U4L9W7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936198">
        <property type="protein sequence ID" value="CCX15556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9W7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4284" checksum="1C47AAFA38BF206C" modified="2013-12-11" version="1">MVALSIKTTDTRKTINAAELVFPPSARIHIEIQKRGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAD7</accession>
    <name>U4LAD7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Formin-binding protein 4 acc. no. Q8N3X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LAD7"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="357" mass="39081" checksum="5726376F8C4E54E5" modified="2013-12-11" version="1">MDTTVQNPIHQTQLPQQGISNPDAASVGQEQLAIQQNVPRYTDTRPPGSDLSSMGPEYHQSQQNYRLQNSQVMTSQTTNMQTVSTQQQVTTEHIQQLPQGWSAHWDQSQQRYYYHNRASGETTWEIPHVQVQLQQPVQPTPPPACEQKQNPQSHITHANTFPQAAQGYIIPQSSQDGSHEQLQRLMSPIQFNPNTLQGSQSPSQPMSPVSPGGISRPQSVMSPVSSLGTPAPVKRVPVPSSIAPAELYGDFHPIQQVSSPVQQKASTPGPTRSASGTPGSASGIHPYPQRTPSLPPQTPSNPNSTTPVSYNQLPTPRMNLKLSLILHLQPKLPHPAPNTKMCIHHKPSPRSPPQTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAK0</accession>
    <name>U4LAK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Vegetative incompatibility protein HET-E-1 acc. no. Q00808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAK0"/>
    <dbReference type="STRING" id="1076935.U4LAK0"/>
    <dbReference type="eggNOG" id="ENOG502STBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WISTIDF"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="246" mass="27830" checksum="784931CBD7032730" modified="2013-12-11" version="1">MTGQAKKSPRPGQASKKFGRAHCNHYQEMESLLLWISPLEEQRKHQKIASKRLPNTGCWFLDTKTFRTWHDEDQGPSLLGCYGIPGAGKSIISSLVIDHLSAKSTGENVCVAFAYCDYGNQEQQSMRNMIGGPFKQVITASNNVTEEIINPLLKINKDRKNLELNDAFEPLLKVLKSFKKTYVCIDALDECSEKHRKEIICYINQLSTLSFTDSTAVPVKIFFTGRPHIKNTSIHIHPLRPQGHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAR8</accession>
    <name>U4LAR8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAR8"/>
    <dbReference type="OrthoDB" id="5458089at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="673" mass="75772" checksum="BE457ADB5D70FCDE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB45</accession>
    <name>U4LB45_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Alcohol oxidase acc. no. Q00922</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936498">
        <property type="protein sequence ID" value="CCX16668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB45"/>
    <dbReference type="STRING" id="1076935.U4LB45"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWNGHDA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="532"/>
            <end position="533"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX16668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="608" mass="65747" checksum="3EE32DFB5EBACE15" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBJ1</accession>
    <name>U4LBJ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935362">
        <property type="protein sequence ID" value="CCX07682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBJ1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="11283" checksum="2DCCDCB28F2D9F93" modified="2013-12-11" version="1">MKSVHRSIPTQRPPSEDCHDFRKPINGSPNAELSTRPRNWFSIRTFRVEASTNAFGKSIPSVNLVCNPPLFPTRRHILHVTFEDELLHLGPGHISVFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBS3</accession>
    <name>U4LBS3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936498">
        <property type="protein sequence ID" value="CCX16677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBS3"/>
    <dbReference type="STRING" id="1076935.U4LBS3"/>
    <dbReference type="OMA" id="PYESTIA"/>
    <dbReference type="OrthoDB" id="5412335at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="625" mass="69247" checksum="44C636A980145696" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBU6</accession>
    <name>U4LBU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBU6"/>
    <dbReference type="OMA" id="WHEADSS"/>
    <dbReference type="OrthoDB" id="5427843at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="895" mass="97385" checksum="AB3E737E5A082C4D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBY0</accession>
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        <submittedName>
            <fullName evidence="4">Similar to Thioredoxin acc. no. P29429</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 100304</strain>
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        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="Thioredoxin_CS"/>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
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        <property type="entry name" value="thioredoxin"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX16789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15519" checksum="89EA5B373E7D885B" modified="2013-12-11" version="1">MTFFRLATTSFRQSTATAAFTAKRSFHATTFKMVHQIQNHEEFKTKVQTAGTGRLAVVDFFATWCGPCKVIAPQLEKMSEEFKDVDFYKLDVDENAAVAGELAVRAMPTFMFFKDGQKLDEVIGANIKAVRSAIEKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCC1</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_07556</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935384">
        <property type="protein sequence ID" value="CCX07967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCC1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6568" checksum="6E3B66D13ED53F0D" modified="2013-12-11" version="1">MLGLFHSIYRGNPRERQNFLPSKILLLHSSISLHNLDPNSFTHLFLQFKYTINSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCC8</accession>
    <name>U4LCC8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCC8"/>
    <dbReference type="STRING" id="1076935.U4LCC8"/>
    <dbReference type="eggNOG" id="KOG2929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="237"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="38459" checksum="10D22C57632B9AB3" modified="2013-12-11" version="1">MFTSRLLRPGVANPPLQTPNYITCLRTSNPCRSYSTPAASHVASLPHRHLLRLSGPDTQKFLHSLTTANILTFSGCLLHTAFLSPQGRVLFDTFIYPRGDNEYLLETDRPVELLQHLKRYKMRSKFTMEAVGDISVRATWGSGVPTTAAEFADPRAEGFGLREVIEAPATEDQEALKSYKLHRILHGLPEGAEEIIPGSALPMESNFDLSKGGIDFRKGCYVGQELTIRTKHTGVVRKRVVPVQLYREGEEVPGELSFAERDFGKIEGGSNIKKVDGKGRPVGRWLTGVGNMGLALVRLEGMTDVKLPGGEEGGLPRWQGEEFAVQDTGVRVKAFVTERMRNYIDGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCU3</accession>
    <name>U4LCU3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Putative fungistatic metabolite acc. no. P84675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936502">
        <property type="protein sequence ID" value="CCX16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LCU3"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMCRAHC"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651248" evidence="8">
        <location>
            <begin position="20"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="918"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1300"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1431"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1568"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1704"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1862"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1405"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1530"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1668"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1802"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1977"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1530"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1542"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1668"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1679"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1804"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1985"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2043"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2062"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2073"/>
            <end position="2085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2098" mass="218207" checksum="4A5139E355890227" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDJ6</accession>
    <name>U4LDJ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDJ6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="28" mass="3504" checksum="615E57A286C122D9" modified="2013-12-11" version="1">MRWFKEHSQFRSEILIDNNLHKHLQQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEH4</accession>
    <name>U4LEH4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEH4"/>
    <dbReference type="STRING" id="1076935.U4LEH4"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWIFWGY"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="34"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX30273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="475" mass="50917" checksum="27631AC115B2E203" modified="2013-12-11" version="1">MSIPTYNETLGSAGGDPHKMDVNAIYQNTGYHMVWVMACTAVVWPIIPGIGLLYGGLARRKASLALLWQSFLVSGVISFQWWFIGYTLTYSRSAGPFIGNFDNIGLRGVAAAPSIGSGYIPEVLFAIFQCFFCVATVQIMIGGALERGRLVPSLVFAFIWATVVYAPVACWTWNASGWLYNLPSLDYAGGGPVHVASGFGALAYAVVLGKRTDKQHKQKHRPHNVTMVFIGTCFIWFGWLCFNGGSTLNATVRAMYAMFNTNIAASTGILGWVITDYFKKGGKFSVVSACEGAIAGLVGITPAAGYVPYWAAALIGFVTASCCAALEEVTEWIKIDESLDVFKLHGLGGLVGSFLTGIFATSDVSLLDGFTEASGAIDGNAIQIAHQLADMVAISAYSFVVSAIILFAMKYIPGLSLRVDESVEIGGLDSHEFYQEEVGDWSVMNKTDNNMLGSMMISQPSTPPQGTSVAEKTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEL9</accession>
    <name>U4LEL9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEL9"/>
    <dbReference type="STRING" id="1076935.U4LEL9"/>
    <dbReference type="OrthoDB" id="5405583at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652211" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20109" checksum="F4D18BE60CF8FFEE" modified="2013-12-11" version="1">MKFSLSTFIIATLASVSFAAPLEARQATPTRVNPSVVAKAYESAPTMAVTVDGYGQTSRYGSGSNSVSSLVYFSQPPGSPWSGKRCNLRFSDPVVLSGSKTFAVFEFIPSNGVTFDISKATWNQRTGYRNRELATFKVGEGSDLVYSYPCPTDGKGLNFELTSSNGDSEIQWNSNWNQGLWLQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF03</accession>
    <name>U4LF03_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Guanine deaminase acc. no. O34598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF03"/>
    <dbReference type="STRING" id="1076935.U4LF03"/>
    <dbReference type="eggNOG" id="ENOG502S6ZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651942" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="214" mass="23788" checksum="30A1520FD6C24021" modified="2013-12-11" version="1">MHFSTLSNIVLFLQICFVLASNAPMEISQEMREHFMRETFTALGSPCPRYPFGTVIVNHTATPPKIICKGHNMNNIHNAYPQLHGEMAAIIECTKVLGTSGGWKDLSLYTNAEACPMCASAIRWAGFKEYIYGTSIKTLIDHNWVQIEISSHEVFQKSETLKSETAIIGSVLTSETDPLFAWQFSAHGQCPHGCMEVPRPGRGRCVPEDIGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF99</accession>
    <name>U4LF99_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Probable alpha-1,6-mannosyltransferase MNN10 acc. no. P50108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_08747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF99"/>
    <dbReference type="STRING" id="1076935.U4LF99"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651957" evidence="5">
        <location>
            <begin position="27"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="42946" checksum="47E14AAC73303D4D" modified="2013-12-11" version="1">MIRPGQTPLQITILLLVLYILHLHWTQPDSVYHTSLQPITVVPASAPVPVSSAAHTPAIPIAAPVPKKNVITLSTDKANWSKSKGGVANGIFQRPHSPQRKGMRIAIATMNTDETSYDHISLRNKFGYANKHNYALKFDLEMPKGLVPMAVWHKLNMIEYLIRTEEFDWIWWIDYDTVITNTETKLEDVILDALRSAEKADEIDFILTADCWPLNAGSMLIRSSSRVLPFLSAVWDCGDPSKSLDEPSEQDCIRDMLLKEPYSKTWGDRALWVPQTKINAFPSEVPCYDKYDKGWSPGDFVVHFAGAWAHLPQHLKKDSYGVLMRKYSEWIDKKELTGGERMQDLDKQDPHWGEEPVVLGTIPPPEKKTDTTTTDKAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFF9</accession>
    <name>U4LFF9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935530">
        <property type="protein sequence ID" value="CCX10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFF9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8300" checksum="FB7B41470A613620" modified="2013-12-11" version="1">MARQESLFPWFLWFAHRGIIARRRRRCCISLRMLVIITLFAASIGETGQLAKTGDLNLIAQFMVGSMCTTDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG31</accession>
    <name>U4LG31_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG31"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8676" checksum="968CC14BA2D319E7" modified="2013-12-11" version="1">MCSFTITANQPFKTPFGVYRFYIAFFSPTYREPCSGLVLPCFLEYLTYACSLVKLGVWRWQLYVAWCGVQQLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGG9</accession>
    <name>U4LGG9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGG9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="4795" checksum="DEBF0955A7354E1C" modified="2013-12-11" version="1">MGIGIGRGLNTTIPESANKLQTLHEFDSQHLRVPFPIFCNIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHL5</accession>
    <name>U4LHL5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative tartrate transporter acc. no. P70786</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935627">
        <property type="protein sequence ID" value="CCX11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHL5"/>
    <dbReference type="STRING" id="1076935.U4LHL5"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WILPNFP"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="484" mass="53153" checksum="1E36C7DA24594A59" modified="2013-12-11" version="1">MDKDTTTTALENASTKSNQQHVEHVPPESLRGISPEEHERLEQVLVRKIDMRLMPMLVIMYIMNYLDRNNIAAARLAGLEQELKLTSTQYQLSVSILFVGYILMQVPSNMFLDKIGRPSLYLPTAMVIWGIISGATAGVTTFGGLIACRFVLGIIEAAYFPGCLFFLSSWYTRKELGFRTAILYSGSLISGAFSGLITAGITDGMNGLKGLLAWRWLFIVEGAATVVIAVTAYWVLPDFPKSTKWLTTQERDLAVWRLEQDVGEADWEGGAKENIFHGLKLAFTDGKTYVLGAILFGEVSSGSVTNFFPTVVLTLGYNPIISLLLTAPPYVVAVITTFLNSYHADKTGERYYHVTLPLWVSIAAFILAAATTATGPRYLAMMLMVPSVYSGYVVSLAWISNTLPRPPAKRAAALAAINAFSNASSIWTAFAYPRSSGPRYIEAMAMNCATAALSILAATGLRWHLARKNKKLDNEGVDGYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI86</accession>
    <name>U4LI86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to extracellular protein, putative [Metarhizium acridum CQMa 102] acc. no. EFY86242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI86"/>
    <dbReference type="STRING" id="1076935.U4LI86"/>
    <dbReference type="eggNOG" id="ENOG502S5ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651479" evidence="2">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="408" mass="42825" checksum="3267C658CBC94443" modified="2013-12-11" version="1">MKPLILSAFISALSLMAPVSAHMALISPPPLRHKVNPHTTNPDYSYTSPITAAQFPCKGYHSLMGTAEGASVASYSPGGTYQIQLEGSATHNGGSCQISLSYDKGKSFQVIKSIIGGCVRPNPGQNQQFSFTIPKNAGGGEALLAWSWINNTGNREFYMNCAVVTIGGKKKRSISGTAGRVEEEVEKRGEKVEGDETMHIWKREGSNPKVEVEDGVMHIWKTRDHSEEPAEAKKLPGEKRVAEASASDSEAPKESELAQLPDHADHEEITDSQSAEGYSSTSSNSTSSDYGSEDYESLSTPLSSISGISKRALGPNLFVANLGNGCTTLGGTDVDYPDPGPNVERGPSQKVAAPVGTCGAVKAGGGGGSSSCDYYRGMGMYCVSGAAGRTMGLGAGLLMAIAASAMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIW2</accession>
    <name>U4LIW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935693">
        <property type="protein sequence ID" value="CCX12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="9" mass="1011" checksum="541E34176AB76877" modified="2013-12-11" version="1">MLGPDPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ42</accession>
    <name>U4LJ42_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935699">
        <property type="protein sequence ID" value="CCX12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ42"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="209" mass="23143" checksum="35B3FD10AB997A82" modified="2013-12-11" version="1">MVGPGVPYNNIVRLDAKDCGAEYEGKDLKYPHQSNGARNKAARDRGKTVPKGRPRKERDVALVSAHDERLEKSAIGTGYNPEEQRQEEVSNPETGSPEGPDHITAGAVARRHDSEEDDPSQDSGTERNDDDSGTEPDPRPPDDGRKHNDESDAGKHKSLAVVVDAPKLARQVDSEIINWLCRDTRVEASQSATNTKQKLIEVYRLHYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ86</accession>
    <name>U4LJ86_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ86"/>
    <dbReference type="STRING" id="1076935.U4LJ86"/>
    <dbReference type="eggNOG" id="ENOG502RYMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RLWSYRN"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47827" checksum="A951F977291EDE1F" modified="2013-12-11" version="1">MENHNHILPLHHERSQQPHPHEAIAYSPPQTEANQLSDLDIGRSPFRLFLRDMMLVIRLLRHLPSMFTPIRTTNPLAELYLGSRRNVQELLLHFFLGILGLLLVLITIPLMIAAPLLVFFLFLVICNCFLCLLSLPLNRGARTLTSKPLPGSPETPEERWIFVNGVCVGNYWLQANINMLSEIFQRPVLGIHNRSYGVIADLVECIAQRCFSYTTNDIRLTYAHLKKDLMDPRIQRVVAIAHSQGGIILSVALDLLFAELACENLAKLEVYTFGCAANHFNNPRRRLAGHEKAEPIIRHMEHFCNENDFVARFGALHFKDPENGRFAGEVFEHKGYSGHLLNQHYLEAMFRAEAATFWDQVVETDQSNPESALSEKTSAVVSNVPLEGDIESLTAAAAQGKSVKELSRLWTYRSGGNPVSRSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJK8</accession>
    <name>U4LJK8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Peroxisome biogenesis protein 19-1 acc. no. Q9SRQ3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJK8"/>
    <dbReference type="STRING" id="1076935.U4LJK8"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASKEVMY"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="312" mass="33459" checksum="B394BCB73AC7B978" modified="2013-12-11" version="1">MADVPHTPAAAAAAATPAATTPAPTPAQQPPPVDLDSDDDFDDDDLLGEFQLGDVPGASAATAPGVAPGVGVAGAAGAAQAPPEVDDEWARMLQEGMRDLLKDVDENPEMHGQFEALAKELNEAMAASSASGEARPGTSSSTTAPTGSFQDQIRQTMERMKSSSAEVDAGLAEDADDDFLAQMLKSMGGGEAGEEDFSNMLVNMMEQLTSKEILYEPMKELNDKYPAWMQENEGKTKKEDLERYRMQMGIVREIVERFDRPGYKDENDEDREYIVERMQRMQSAGAPPAELMGDMAEGMQPPDMSAGDCGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJM5</accession>
    <name>U4LJM5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJM5"/>
    <dbReference type="STRING" id="1076935.U4LJM5"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="59"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="218" mass="24281" checksum="FDF200557BB51ABA" modified="2013-12-11" version="1">MASFRTFTPLLRRPFSTCASSTPILPKTSFFLKPTSSFTQVRLNSTSNTMSNTYFDITHVDNQGNRANWGRIVFKLYDDVVPKTARNFRELCENTNVGQGYIGSKFHRVIAGFMAQGGDFTRGNGTGGRSIYGEKFQDENFIKHHDRPFLLSMANAGPNTNGSQFFITFVKTPHLDGKHVVFGEVVEGEDIIKKMESKSLDNTGRTSGTIIIEKCGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKB2</accession>
    <name>U4LKB2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX32012.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKB2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32012.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="1957" checksum="5CA6A84407E2FFC8" modified="2014-03-19" version="2">MYITLTTLLETCAIRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKD8</accession>
    <name>U4LKD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Heat shock factor protein 2 acc. no. P38533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKD8"/>
    <dbReference type="STRING" id="1076935.U4LKD8"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEYENPY"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="181"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="798" mass="85496" checksum="6855A8221262CC7C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKL4</accession>
    <name>U4LKL4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKL4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9715" checksum="75958857FA441CCD" modified="2013-12-11" version="1">MPVQRLGGVCSDERLRSRDIISIRDSIRCIRAVGEEANMLSQHKWNPSSVQTNCAIISILPTYTLRRKPADSAWKNGTQFPRSSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL05</accession>
    <name>U4LL05_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL05"/>
    <dbReference type="STRING" id="1076935.U4LL05"/>
    <dbReference type="eggNOG" id="KOG4122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MNRISPF"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="97" mass="10823" checksum="336F50E5514BBB15" modified="2013-12-11" version="1">MLSATSSALRGTFLRFAALSRPALTRTFTSFPNTLSSRLPVTRTLGATTPLFQQTTQRGMKVRSSVKKLCDGCMSVRRKGRVYIICSKNQKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLM2</accession>
    <name>U4LLM2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935431">
        <property type="protein sequence ID" value="CCX30250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLM2"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34207" checksum="C5631E270FDCBB65" modified="2013-12-11" version="1">MSGRTISDAKFTYSPDLGLLYDAEPRDTQTTITERVKSGDINLKWLKAQLAHYQLRVSGNKQDLAVRLTKAASSGKLKNQPKDNKELEKSLKAAYEARLSTPGKVTNGGITKATKSAASDTPSTSSTSSKSDRGENQPRGKRKESAALHAAIIAGSKKAYNLASLYSPELRNFKVLGTGKSLASKPPWVSDESVLGHYALTCEEFPEAESSLFLKRHPTGPRIIGEFIFNFEAGKFSTTAMLDWPKKREERFFTVEGIRGEIQFRYCNGQMEVEGRLETATYGDVDWNGTKSKVETAVSIEPKRNEVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLT4</accession>
    <name>U4LLT4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_14135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLT4"/>
    <dbReference type="STRING" id="1076935.U4LLT4"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HFHVEGP"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="26056" checksum="C68498A01181C7D4" modified="2013-12-11" version="1">MPPLTGARSLSAAVLSATLRRRLPHACQLRLASTSSTASTASTSSNGSKPQQVTVRGDVSSRRWADLSGGQKIVRSTSVGFNSLTILLGLAVTGSIVTFVYLEVIAPDSVTNWFNRAADRVNSDSRCKALLGDGKIKAYGEETYNRWARNRPIAATANTDKYGVEHLRMRFYVEGDLEKGTVHLHCAKRPGEDEYEYRYLYLDVPGRSRVYLENADDTRQYGESKRGFLGVRWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLT9</accession>
    <name>U4LLT9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLT9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="7869" checksum="4364C1F0580AE430" modified="2013-12-11" version="1">MMTRAPGILLNSIILCHSNPNPHRNFYHDRHNLASITLPSHFQLLAHGKVIFLARNPETTPTGNEDRVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLV5</accession>
    <name>U4LLV5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLV5"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14333" checksum="742B25762372F6EE" modified="2013-12-11" version="1">MLRTNVTRRLVITRNFSTTRVVLAPNSQPSQVIGHVKWVKGMGEEMIGTVFSSKLKEAGLADKKAGIEEMRAAKAIGDKIVEEKVAHEGPVRLAAEGRTEGMLGKMFCCEGMKERGEFKVETAKEKIDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMF8</accession>
    <name>U4LMF8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMF8"/>
    <dbReference type="STRING" id="1076935.U4LMF8"/>
    <dbReference type="eggNOG" id="KOG1261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHLPERH"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="165"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="416"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="541" mass="60793" checksum="C7953F37A5467BAF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMV2</accession>
    <name>U4LMV2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33268.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMV2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33268.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="1975" checksum="235D1481D822CAAF" modified="2014-03-19" version="2">MLQSPFLSSNTNWYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNA2</accession>
    <name>U4LNA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Zinc finger FYVE domain-containing protein 19 acc. no. Q96K21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNA2"/>
    <dbReference type="STRING" id="1076935.U4LNA2"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="479" mass="52388" checksum="34152E7F9C1DACB7" modified="2013-12-11" version="1">MPTHDASLAARLAALRGPPKPPPSDTDLNSRFEKLFSHAPGDKTVTTKPDGARAAAVASSGTGEEGETEGDEEMKTEGLGEGDEEDYEVKARDLLKLTKEWDEEAGKDIKTLVGEAEEAGRQFHGRGVGEKGDEEEMRRLLKQAEEEGWSTTEELGFGYDDDWEGEPSWLVDAATEKEDREGGWDGEKPREEIQRDEERCYRSSAPSPEPVAARYGEGGGYNEKRADDKMGLELPSVPTLPAVPKELRTMEEKQEITELGQILPDAPVDDEEADAIVRRIKEEIEWETRHGIKDADDEDDEDSDDKEPKGSDSDNHDSGDEAPGKRKPKTSEKTATKASKEDDDTILSKLSARFAALGGMGKKSSATTSKSITPTDSTSPPSGGLLDLPSVPTGLSLPSAPSSAPGTSTPKKNKKKQEEEVDEVDTWCCICTEDAEWRCEGCEGDIYCATCIYEAHTGAEEKRHRWGRYVRPGRRLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNI2</accession>
    <name>U4LNI2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Origin recognition complex subunit 3 acc. no. Q5DJU3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNI2"/>
    <dbReference type="STRING" id="1076935.U4LNI2"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CPTFMFF"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="616" mass="68576" checksum="3997E24699A9687E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNJ2</accession>
    <name>U4LNJ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_14197</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNJ2"/>
    <dbReference type="STRING" id="1076935.U4LNJ2"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="61"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="331"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="554" mass="61963" checksum="00C78187B0A48611" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNL8</accession>
    <name>U4LNL8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative lipase ROG1 acc. no. P53118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_14222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
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        <property type="protein sequence ID" value="CCX33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="DUF676_lipase-like"/>
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    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
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            <begin position="286"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
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            <end position="274"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="1030"/>
            <end position="1088"/>
        </location>
    </feature>
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        <location>
            <begin position="1138"/>
            <end position="1162"/>
        </location>
    </feature>
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        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
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        <location>
            <begin position="959"/>
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        </location>
    </feature>
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        <location>
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            <end position="1054"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
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        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
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            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
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            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
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            <end position="694"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
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        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
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        <location>
            <begin position="788"/>
            <end position="806"/>
        </location>
    </feature>
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        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX33618.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936082">
        <property type="protein sequence ID" value="CCX33437.1"/>
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    <dbReference type="AlphaFoldDB" id="U4LPD3"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651539" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="111" mass="12288" checksum="9D9E9E36B36BFBCB" modified="2013-12-11" version="1">MKFATLLLIAGALMATAMPTDVEGNALMSRRADLNLAVESSSSIISTSDRQGDSADEKAITILRRNHGDKCFWSKCGRGCQNKEFYGAFKKQCGFLNFQETWFCCPNAHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ49</accession>
    <name>U4LQ49_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Laccase-2 acc. no. Q96WM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_10802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ49"/>
    <dbReference type="STRING" id="1076935.U4LQ49"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DHSKMAM"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651662" evidence="7">
        <location>
            <begin position="21"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="88"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="213"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="444"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX31455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="596" mass="66740" checksum="01F6578EE556C27E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQF0</accession>
    <name>U4LQF0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Mitochondrial import inner membrane translocase subunit tim23 acc. no. Q9USM7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQF0"/>
    <dbReference type="STRING" id="1076935.U4LQF0"/>
    <dbReference type="eggNOG" id="KOG3324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQPTPFD"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="22806" checksum="A250CBC382D0FA1D" modified="2013-12-11" version="1">MASFWNALTGKSRKNTEDNAPADSGDIAPTTTFAAPAFDPSTAADVSAFLKPVGTAGFDPSALHPLAGLGSDLTYLDVDDAALSAIPGGQSLLPSRGWSDDLCYGTGATYLVGLSLGGAWGFVEGLRKVAPEAPPRLKLNGVLNAVTRRGPFMGNSAGVVAMVYNGINSTIGYYRGKHDTANSVLSGAIAGAIFKSTRGVKPMAISAGIVGSLAGAWSVGSKALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRL9</accession>
    <name>U4LRL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRL9"/>
    <dbReference type="OrthoDB" id="5459133at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="333" mass="37836" checksum="60A401ACFCACE66E" modified="2013-12-11" version="1">MSPHQWPLPVELGLDANDPFYNLYTVLYDSYQASSTATTALRNDIHILRCANSEFLAKLENQESHIKLLEQFTKTQRSVEQERDDALDELRRTNLAKKEIQEQLVNFAKRNVILLNEITQKNKENHHLVIKFENAKDYALEELEELRKEVEDAKNLAMEKQDELENLRRTLSTALFRRNQSSTNNSDTGSILSSSTIGRELAYPADDNTEDDFDNESTLVASTLRSRQTSSTLSRKMSQDTIRTPTASVYSAVTSPSNGTQSSIPKDLHPLRRRGSMSVFSLSLNRNEPTPAVNTPDENDGIAKNKPATCQRFAKKSHNSLKFWRRNKEEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS84</accession>
    <name>U4LS84_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Increased recombination centers protein 22-2 acc. no. C5M501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_03713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS84"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652345" evidence="10">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="176" mass="19426" checksum="C54EBF7ED74AB5C3" modified="2013-12-11" version="1">MKFTAPILSALSLIGSAAALNLNHTVTAPDAATCTNGIPSRISIKITNNEPNTVTLQSLSAALVKEDGTVLRNFTDMKIGKAVKKGQNIEKHFVFTTHFDPQFATLELYAAVQDSDKVQTVIPAYKGQVQIVEPEAGIFDPQMWFLYLLLLTGFSTAGWYAYNTWFVTVTPKRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSN4</accession>
    <name>U4LSN4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSN4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7471" checksum="8899DAEF73109363" modified="2013-12-11" version="1">MRHHDSNPSFPSNKQQRVFELLPPCPFAHLSIPIHVFHFHSTPIQTTNTFEQSCTLVEICSNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSR9</accession>
    <name>U4LSR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSR9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="111" mass="12546" checksum="A91A872F277301CE" modified="2013-12-11" version="1">MIIGNPVVHDSIPITTAKNFSTTATDRILLRPPHAYFSCSASYANHGAFIRLLSKAYQRCTRGIPFCTRNYFTRFSLLVSLVLPTSASTYIAGGFRHPPRQYGMIVPHRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT24</accession>
    <name>U4LT24_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT24"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10179" checksum="399A5E8E10038C29" modified="2013-12-11" version="1">MLLGNNRSEAGRRRDRRVLLLTPAAARLRASRQTAQEQIPLCMGREASSSVAPGQLKLPRGGPGAKGADQRVQGPQILFHRLRASPTSLKNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT82</accession>
    <name>U4LT82_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT82"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15529" checksum="6D085D89655E84B9" modified="2013-12-11" version="1">MTGCPKSARDKRAARRNGGGCQVQPSLTGLTPVCGTVGVNKVYHPPETPISEDFETEEELHEYLYQRGMDPATKISAMQNRTHPLAKKYAQWTKGGVSTLTQRIFIAEEKAQWEMFQQKMLDQLRREGSTSGKNVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTQ3</accession>
    <name>U4LTQ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Monothiol glutaredoxin-4 acc. no. O74790</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_14049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTQ3"/>
    <dbReference type="STRING" id="1076935.U4LTQ3"/>
    <dbReference type="eggNOG" id="KOG0911">
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    </dbReference>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="25446" checksum="BA2DEC2350825481" modified="2013-12-11" version="1">MATVQDITSVEQFNELISNAPETSLVVLNFHAPWAAPCAQMNQVFSTLASQSTASTLFLAIDAEEHPDISETYEVSAVPYFVLLRNNTSLDTISGADPAKLTAAVTKHSNGATFALPPAQSAVASASEGPQEEEDINTRLGKLVAAAPVMLFMKGTPASPQCGFSKKLVALLREKEVRYGFFNILADDEVRQGLKVYSDWPTYPQLYVKGELVGGLDIVREEMENDPSFLQDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTW6</accession>
    <name>U4LTW6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTW6"/>
    <dbReference type="STRING" id="1076935.U4LTW6"/>
    <dbReference type="eggNOG" id="ENOG502S01X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CIWHSIG"/>
    <dbReference type="OrthoDB" id="5395343at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="226"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="948" mass="103117" checksum="079906C1A500647B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU79</accession>
    <name>U4LU79_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU79"/>
    <dbReference type="STRING" id="1076935.U4LU79"/>
    <dbReference type="eggNOG" id="KOG4031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYENYNT"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="26322" checksum="8C07E3FAA6D8BA4F" modified="2013-12-11" version="1">MASRFPSIEEFDDGQTGIPDLSSGVDALDLGLDSDPTADFLSREKATLGADADLFASENDNNLLGGADEHAAATSAFESSFPSLESTNEMDGPGGTITGGAEPYMPGHNTYTGMPNETEEEPEVVRQWRERQQLEIAKRTEVSEKRKAETIKQAQQDIDDFYENYNTKRDKAVAETRREAQEFLDNRENTVAGGTAWERIAKLVDLSDKGVRAGKSDKTQFRAMLLSLRKDEKAPGASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUN3</accession>
    <name>U4LUN3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protein SAP1 acc. no. P39955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <text evidence="1">Belongs to the AAA ATPase family.</text>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="557"/>
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        </location>
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            <begin position="122"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="204"/>
            <end position="240"/>
        </location>
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            <begin position="254"/>
            <end position="484"/>
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            <begin position="282"/>
            <end position="296"/>
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            <begin position="381"/>
            <end position="391"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="426"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX31796.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <begin position="188"/>
            <end position="207"/>
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            <begin position="1"/>
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            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
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            <end position="97"/>
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    </feature>
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        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX31881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="573" mass="63483" checksum="B3A9A63CB9150247" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV49</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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            <strain evidence="2">CBS 100304</strain>
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        <source>
            <dbReference type="EMBL" id="CCX32216.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="19" mass="2193" checksum="625B59E6762965EA" modified="2013-12-11" version="1">MKPTVPSQKTVNLKSNTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVA1</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <source>
            <dbReference type="EMBL" id="CCX32351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9121" checksum="134344FF3D9CD3A9" modified="2013-12-11" version="1">MSSRLMLDEFQIAGYTASTNPTDCRFLVSVCLFSRPPRDLVFLAVRRNCPARHLGCLVRQSRFGPVNDGGLWAFTTVSIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW74</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <source>
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        </source>
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    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
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        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="624" mass="70382" checksum="0AF5F7D93F30B9FC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWW2</accession>
    <name>U4LWW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Choline/Carnitine o-acyltransferase [Saccharomonospora xinjiangensis XJ-54] acc. no. ZP_09986069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWW2"/>
    <dbReference type="STRING" id="1076935.U4LWW2"/>
    <dbReference type="OrthoDB" id="5367651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="3">
        <location>
            <begin position="100"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="616" mass="67172" checksum="DFC711F4062DCC84" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXQ1</accession>
    <name>U4LXQ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936570">
        <property type="protein sequence ID" value="CCX34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXQ1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="7026" checksum="E2072B7A9CFACE36" modified="2013-12-11" version="1">MKQNSIKQRHPHRNVSANCAPFHAALCRLRVSYHRADSSQDTSCHLASRMIPKPKCRCRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYD0</accession>
    <name>U4LYD0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein L93 acc. no. Q5UPG5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYD0"/>
    <dbReference type="STRING" id="1076935.U4LYD0"/>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETEDMAC"/>
    <dbReference type="OrthoDB" id="4837942at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="561" mass="62338" checksum="06EFF8C73EE090C6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYK7</accession>
    <name>U4LYK7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C15A10.09c acc. no. O13729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYK7"/>
    <dbReference type="STRING" id="1076935.U4LYK7"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="19542" checksum="FD660AFD9E6CE8EF" modified="2013-12-11" version="1">MFDRTRPSSSQSGIGSGSGTATSERSHKPDETPSASTIAGSPPSTGCDNAAASQLRQPRAKSLLTIIAQCCSFASIIFMILVLVGNTRKVKALTNIYFLSIDVSNVIPRSYPNAVLVNSIAQTLGLRGFYQVGLWNHCEGYPNEGVTYCAPTKSMYSFDPVTILLSQLLEGATSKTSLTRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU35</accession>
    <name>U4KU35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU35"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12945" checksum="DF2417DA503F0E18" modified="2013-12-11" version="1">MRCRFWTPLDTGVKFLNRLSAVVERGKPTFPPIPNIDKPITSPDHHPASSSPISRSRLRCSFRDFMRFRCDFGVLHLDRYRLGGLDAGTVGWRGFFRETGGCSLQWCSCGCCSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUW6</accession>
    <name>U4KUW6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUW6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="83" mass="9678" checksum="687CD893892CBDF3" modified="2013-12-11" version="1">MYDSDEDVYRFETKVDCDCPAEEYGGLSSVTLENLLDYVAQKVPYLRDGQFSLHESRFSILHPTSYYGICRASCFICHFRNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVX3</accession>
    <name>U4KVX3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Glutathione S-transferase GST-6.0 acc. no. P15214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVX3"/>
    <dbReference type="STRING" id="1076935.U4KVX3"/>
    <dbReference type="eggNOG" id="ENOG502S500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRCPWAH"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="27023" checksum="B341C975F1D545B4" modified="2013-12-11" version="1">MSANLTFYTNRYCPWASRAHIALQELGLEFKEEFVDLTKPRTEEYLKINPRGLVPALQYKDTILIESGIITQFLADLPGNSKSILPAPTTPEACLFRARLTLFVDTFISKVGSQLYQIMLNSKDEAEKETKIANALEAIKKDIVPMLEIKDAEKPNGPFFGGSEEFTLAEVNCASFLIRIYKLGQEKHGLIPASFVKGLEQIEVFNNWAQACIKRESVSSIFDEEANVARWNEKIAAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXX5</accession>
    <name>U4KXX5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935287">
        <property type="protein sequence ID" value="CCX06385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXX5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="20754" checksum="DAEDFE3B6B8C9F9F" modified="2013-12-11" version="1">MPRHPKRREHKRDYRVIGNLSRRKMPSLISFLRIGSLKSKPTDTSSTTTTAAPAAAALTTPVPVRSSVGTVSGRRRVSSSPAQPQLATTQQSRDRNSLPVSIPQRAVSQSLHSQGHETIEERVMRKSHDTAPLWRSPANFSVSNGGGAQGSTKGGDGGGYRSGTTGGGGGMVDTGVNQQNAQGAAFAAAGAVMMSGAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYB5</accession>
    <name>U4KYB5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYB5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7618" checksum="0497253386E3CB17" modified="2013-12-11" version="1">MDGKMATGNGIHINCSLPHHHNLGLHSIVMADECVNLRLEVFPRESSTALRYGYRRFRYLQATMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYF5</accession>
    <name>U4KYF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935346">
        <property type="protein sequence ID" value="CCX07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYF5"/>
    <dbReference type="OrthoDB" id="5471747at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="310" mass="34482" checksum="B29F60062FDDDB39" modified="2013-12-11" version="1">MNSVMYPAMYTLHPAAAHQVSSSVYTTSNYSGYTDDSGYASNLSEYYDYTSHPPSPSSFSAFYSPSLVPPAPAPPPQPAKRPLFPAQNPRACFPLTQPWPYTYCSTCHKDFRMARKAHTAVSGYALLKPPADGREFCVAFLPEGDRSLLFWLAVCRGWVVTERSGLPGDARGRMDMGDGDDGGKGKGRAKEQDAEEELGWVVYIYSCSPLGPYTNAVDLSIAFTGDPDIQGIGIPKGAMWFKASPEDTEMRRKRGAEERITRGKFTEWIRRGECRHAWERLGMLKVAWLDQMGEEGWKRTDVVSTEFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYU8</accession>
    <name>U4KYU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Malonate--CoA ligase acc. no. Q8H151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYU8"/>
    <dbReference type="STRING" id="1076935.U4KYU8"/>
    <dbReference type="eggNOG" id="ENOG502SJHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MGSLCHM"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="47929" checksum="7F2044ECECA50C14" modified="2013-12-11" version="1">MSRLTGFTYTDYVHFFALFRAGYIPQPFSLHPRFPHLVSGMMKKSNALTILLDPSVSDIIPGHLIPTLEAISATELPLIDEETVKGAFYMTSGSTSDLPKLVHHNLKAFQTLVYKTSTATNHGIINALGSICYVGQLGVLMANMHHCCPIILPTGIPFQKDELLAMFHQLSMRRLILFPTHITTFFRQSKIDPELLEVLKQFHQVAYTGAPLPSSDISYALENGIKLQSVAGQTELFGTLRSPIGDPESSRPVPGVKYHFTEQGELVVLKDSIDIPSQREFLAEDGCFYTGDIFEKKGDGWRFVGRNDDRIKAEYGGYYWPRYIEDEVIRVCSDVVTSCIVLGAGRISPTLVVEVEDINSEEAKSIPKLVVQRLKGWMEKRYSHESIVEEKFVVVVKKGELPRTANKGNVRRAAAEKQFKELLDGIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYX0</accession>
    <name>U4KYX0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935340">
        <property type="protein sequence ID" value="CCX07196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYX0"/>
    <dbReference type="STRING" id="1076935.U4KYX0"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LIVLWTW"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="709" mass="78023" checksum="19635C2C9F411831" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYY7</accession>
    <name>U4KYY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Salicylaldehyde dehydrogenase acc. no. P0A390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935343">
        <property type="protein sequence ID" value="CCX07221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYY7"/>
    <dbReference type="STRING" id="1076935.U4KYY7"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFGGEKH"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="471" mass="50497" checksum="244EB2446D430B3F" modified="2013-12-11" version="1">MTSDFISPLIINGVERVGPKTGPVISPATGKQIWSHTSASVKDVDDAVSAATAAFPAWKATQLKDRRNLILKAADALEASYDEIAEAMKQETASDDGWAAFNINTSLEVMRGVAQRLPSIEGRIPQCDDPNMTAMVVKEPYGVVLAIAPWNAPIILAIRAIVFPLAAGNTVVFKSSELSPRTHYLTARIFAQAGFPAGTVNLLGHVREDAETITTAIISSPMVRKVNFTGSTPIGRKIAEISGRHLTPATLELGGKAPMIVCEDADLEAAAIGGAFGAMHHAGQICMSTEKILVHESVAEKFTEGLKAAVQKMYGTSQYLIQSSGVDRVDGLAKDAARLGAGVFPEAQKQQNLNEYNNTVVCNANDKMKLWQTESFGPVVMVSKWTDEEEAIKMANDTEYGLSAAVWTKDIGRGIRIARRIESGAVHINGATVHDEVALPHGGVKNSGYGRFGGTWGLEEFMTTKTITFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ69</accession>
    <name>U4KZ69_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Guanine nucleotide-binding protein subunit alpha acc. no. O74227</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935364">
        <property type="protein sequence ID" value="CCX07725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ69"/>
    <dbReference type="STRING" id="1076935.U4KZ69"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="353" mass="40885" checksum="D9921274463252F7" modified="2013-12-11" version="1">MGCGMSTEEKEGKLRNEEIENTLKKDRMMQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIFSNTVQSMRVILEAMESLELPLDDNRGEYHVQTIFMQPTQIEGDSLPPEVGNAIRSLWQDRGVQQCFGRSREYQLNDSARYYFDSIDRIAAADYTPSDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFREKLPVSPMKNYFSDYEGGDDYTAACDYILNRFVSLNQSETKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRQCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZI4</accession>
    <name>U4KZI4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZI4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6235" checksum="BE23AB22614235B2" modified="2013-12-11" version="1">MQTLFLNRSIYLPNYRLACLLYPSAFVFHPFSFPSSLSSPSTTTSIERTSSITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZJ6</accession>
    <name>U4KZJ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Uncharacterized protein C26F1.02 acc. no. Q10492</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_04706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZJ6"/>
    <dbReference type="STRING" id="1076935.U4KZJ6"/>
    <dbReference type="eggNOG" id="KOG3756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYYLPYR"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="58"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX05119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37877" checksum="B06CC5227AF09E82" modified="2013-12-11" version="1">MSDAAEPITVASAVVLPESTKRRASLDTPESSKRARLSPGPEDSHAPERSERRKHGLEEEKKRGKRLFGALLGTIGKFQKDSSSVRARNSAVKRKEVEAKLQEKLKQQDEELDEKRRKEQDDYTLRKRVESRDFEERAVGGPSAMDYTVGGSRLMNKQMQIKNATITAQANMLATTTEPKLYFLPWKLLPAEEETIAQQKETALQTVADNEAAFRDMRKQIEEELQAAGVDATGEGFPGGDNKGHDGHDEHNGHDGHDRHDEHKVKQEDHEMKDEPQDEPDISIHSPSPQDDVAEVPEVAETEAQPKQEPQPEVKTEDLDVVDTDMVIEEGGEDTVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZL7</accession>
    <name>U4KZL7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZL7"/>
    <dbReference type="STRING" id="1076935.U4KZL7"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VFRRCVA"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="97"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="30504" checksum="99CC70ED09E577D4" modified="2013-12-11" version="1">MANNAGYDVVVDVDDDDGDLGHTDLADLEFHQSNYNADQASGKIPSNQNRGFFNSGSGSGTARSEPTGKRYLWSLDFYAQFFDVDTNEVMKRCWAALWPKAMFLDVLEDRPDLYGPFWITTTVVLILFLTSTLSHYFARMKDEPYSYDFGLLSGAAGLMYGYTAFIPVALWGVLKWYGSESAKLLECLCLYGYANLIWVPVAIASASPITILNWVFVGIGFGVSALFLLRNLYPVVSATDAKTAKILLIVVVVLHAALALTVKILFFQHGSPVKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L062</accession>
    <name>U4L062_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="HF935382">
        <property type="protein sequence ID" value="CCX07914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L062"/>
    <dbReference type="STRING" id="1076935.U4L062"/>
    <dbReference type="eggNOG" id="ENOG502S3AW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKEIAVP"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005147624" description="Cutinase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX07914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="25307" checksum="7D07DFF6D3F777A5" modified="2013-12-11" version="1">MQFTSLALLALSALAIAAPSPVPANAAVSSTTQSVEMDSAIYSRLEKAFQDAAVGKQTSTVSARAGSDVRNDVINGQCNDIILIFARGTYGSGNIGTGIGVAFADNLIAQRPGKVAVQGVQPYAALISGYLAGGDEEGANSMASLTAKAVSQCPNSKIIWGGYSQGAQVTHKAAARISTSLHSKIYAIALFGDPNDGQAFPGALNGKVRTWCHSNDPICDGIPLPIDGHLTYEADAPAAAAWAASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0B7</accession>
    <name>U4L0B7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935414">
        <property type="protein sequence ID" value="CCX08412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0B7"/>
    <dbReference type="STRING" id="1076935.U4L0B7"/>
    <dbReference type="OMA" id="EAPCDEN"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX08412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="553" mass="64288" checksum="03B6C391F191106F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0S5</accession>
    <name>U4L0S5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935263">
        <property type="protein sequence ID" value="CCX05649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0S5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8314" checksum="A89DE795D1A910FB" modified="2013-12-11" version="1">MHSCTSRSSGSLADERKTKMMSRRIKKKVMANDLRIHLENSLNRQGLDARHAAIICMNFLGAKVLRNPAEYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L108</accession>
    <name>U4L108_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative ankyrin repeat protein FPV162 acc. no. Q9J569</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935457">
        <property type="protein sequence ID" value="CCX09322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L108"/>
    <dbReference type="STRING" id="1076935.U4L108"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="710" mass="79682" checksum="59115BC1E7457827" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L125</accession>
    <name>U4L125_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to GTP-binding protein ryh1 acc. no. P17608</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_05356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L125"/>
    <dbReference type="STRING" id="1076935.U4L125"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="210" mass="23628" checksum="A3EBEBDD36F8E680" modified="2013-12-11" version="1">MASPSQPVSSYANPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLDDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDITNRASFMNTSKWVDDVRGERGNDVIIVLVGNKTDLNDKRQVTTEEGEKKAKEFKVMFIETSAKAGHNVKPLFKKIAQALPGMEGTMPEQNTEMINVDIKNQEGSQQEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1A5</accession>
    <name>U4L1A5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Esterase acc. no. P18773</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935402">
        <property type="protein sequence ID" value="CCX08237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1A5"/>
    <dbReference type="STRING" id="1076935.U4L1A5"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DMACVEP"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="42279" checksum="2625ED84B2258212" modified="2013-12-11" version="1">MEVASKPSLSLREKISLLVRILIVYPYSLVSFILRNLLVRDRWWFRVKNAGSRCLTGSMTVKQLQYLFPSTPTVYKKWTRAKGLLSNTEEFPAENDGEVGARIMWVGEAWKPGQKLLLYFHGGGYVLSMMKGHLEFLNYVKRTAVDSELKDSLAIAVLEYTTAPAQKYPFQIREATQALSRLLARGIPPSDITISGDSAGGHLALSVVSHILHPRPTIPRLSLDSPLAGLALLSPATCLSSTKASSFQKYGSIDVLDPAICQHWTSQLTDNSEFSADLASGNYWGEAAPAPESWWKGIRSVAKKMLITAGEEEVLIDDIRVFIKTMEGVFEKEGGSFQLETLVAKGEVHDAPLMDFIINFKRSETTRRTAEFIVETFRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1E9</accession>
    <name>U4L1E9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935275">
        <property type="protein sequence ID" value="CCX05904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1E9"/>
    <dbReference type="OrthoDB" id="5428674at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="325" mass="36249" checksum="B2708B293EC9DD83" modified="2013-12-11" version="1">MSTTTTTTINNNNTACISLTGIGGSSDAQNLITAPCTRCGHHEEIKSILRVVAAAKPSTSVPATEAAAEDEDLTSTLTTLTTVLRRHGEDLNAITLLKPSTPNDVAPGNPLVHDPEDLKHLTSGVTRLMCTLHDKVTRLDVAEREMKRKAERLEEEKRRFEEERREFRRLTMVSPMGRKSGQSFDSDDEKRPNLANRLSFYEAAVWDDEKEAQLQAAEKKLSWANRNWSPEQEDVLPMVEALREEKRRAKKYSTLLLSTSPSAPKTRRSFSMSKSSKKDLKLRKSASSVVEIRDKEGKRRGSEGDEGKKGSSFLRFFGRKSASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1I0</accession>
    <name>U4L1I0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1I0"/>
    <dbReference type="OrthoDB" id="10456610at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="443" mass="50536" checksum="F7654C8824FE2784" modified="2013-12-11" version="1">MTDLFDIFSNPWCDSVSERDILSRERSTEASPTVPRTVTVAANKYDRDPASTASIASQPEHEETEELPETETGTEEDGFAKEKETAELSGNETVAKEDGFNEEEEELARQLQKELLLEEVLSDTHVLTPPGTPPREGPREPNDDEAEEERALLEFELCKLRIDAYVLEDELKEVRREKRILEVQNQDLTERILREVTESQRLREELESTKVQLRKALYLGVRARVPPHKPSKPQFGFPGPLRTKLPPVDPPPFKEYVGLQQVAFDQLAQKVTVPIKSFGEALKEAHEGRVSEKKPETFGIPVNTNTAVVPAKSIFEVQRNLPSATFYYEPHLDVGSSSLYSHISAVALYRNMSAEELRLADYQRGYRYPIAGVPAVPVPALVQPKVHFLKERGPKPEEFMQVRWRESGLLVMLNNIVFMPCYVHKSQEELRLEHYEQGWRYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1R8</accession>
    <name>U4L1R8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935417">
        <property type="protein sequence ID" value="CCX08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1R8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6473" checksum="A12B8F0C170DE006" modified="2013-12-11" version="1">MSSATVRICKSHVQKNGQNVPEDLAVALQKLSEEGKIPVGFYNATSFLHSRKVITDPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L268</accession>
    <name>U4L268_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized hydroxylase C887.15c acc. no. O94298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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    </evidence>
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</entry>
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    <accession>U4L2T4</accession>
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            <end position="248"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="743" mass="79318" checksum="14DA1A0E08FE7EB5" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4L3M9</accession>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="62" mass="6737" checksum="E88E0FB15F3D11A8" modified="2013-12-11" version="1">MICTRPESGCMQISATLIMISSPTRWFSANTGPSAFPKLSLSPAWQTRPNLTVHGFDAKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3N8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="262" mass="28606" checksum="4BAA90498DDA1131" modified="2013-12-11" version="1">MVHPELNQCLSCIANIQEAANSAHPEANSVHSASIVARHVKGYHDHKCSSMIHLCRACDDPDNYGAAFKNCREKLFSMRSKARKQTITATPVTIMQSDATVTVTAYTSIIPSDIYFTTLEPTPLSSVTANMAANQTFNTNSGYQTDYSSDGYNQAAKTQMTRAQVTGLAAVLVATVFMGLSALITFLVIRYRRQNPRVSGKKLELPESTAELPGSSEILEAPIDRPVIQIVYEAPDTAKCITRTNTDFSEDPWLGPPLSQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L496</accession>
    <name>U4L496_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L496"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="19807" checksum="F9A618F06F07EF35" modified="2013-12-11" version="1">MRRSKIKGPGPENLLLNIAEVAEILSDLEVAHQFQLQFMKSLNGAGMKLFLYEGLDSDLASCVDALKRMDHIGKAIQTTNSSKIDTLFQRASNMITIDEAARARKQGASIKRLTWITSLYGMNIDIIQKKNALDKRFMDIDSCIYHGYDCCQYPQRSETVIRLHCKNFPQNQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Z8</accession>
    <name>U4L4Z8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Epoxide hydrolase 2 acc. no. P80299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Z8"/>
    <dbReference type="STRING" id="1076935.U4L4Z8"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQIPMLV"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="40"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="38639" checksum="99DCBA88369345F5" modified="2013-12-11" version="1">MAPKPIDPYNDDRVTHEFANVRGKKYHYVHGMPKGRVRATVLTIHGFPDLWYSWRFIIPALLDMGLRVITPDMIGYGQTDAPRCAANKMEPYGWKSIADDMAELLRQLDVPKVILLGHDWGGVIVSRIYLHHPDIVTHVASVCTPYYGLTREYIPIEEYIKKVPTFTYQVAFADPQTEKDLEKRSEIDRFFRAVHRGLGDGPSGEIQVTKNFMMSLGDSPRGKLLTQQDLEYYVDQYSRNGFHGPLNYYRTRYQNYLDEKDMARSSIIDVPYLYIAATHDIATPPSLANTVGQARNIPNLMVREVKSSHWALVECPDEVIGILDEWINTVCLGNKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L500</accession>
    <name>U4L500_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935679">
        <property type="protein sequence ID" value="CCX12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L500"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="121" mass="14110" checksum="2BE12794C551D042" modified="2013-12-11" version="1">MARFSAAPLNKCLIPSEEEEHDEFLAKVAKEEEEMGEPIISREDIKGSFFLVHCLVIVCFLFCGSALELSHDRDECILKTVDDPFWLFGMLVLLTPRYLANNSIEIQKMLDYWHFRKNDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5N2</accession>
    <name>U4L5N2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Ferric reductase transmembrane component 3 acc. no. Q08905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_11956</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935701">
        <property type="protein sequence ID" value="CCX12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5N2"/>
    <dbReference type="STRING" id="1076935.U4L5N2"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDGWTRH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="269"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="602" mass="68500" checksum="C6575DD772CC47BF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5N7</accession>
    <name>U4L5N7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935704">
        <property type="protein sequence ID" value="CCX12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5N7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8837" checksum="22158DE511317A57" modified="2013-12-11" version="1">MKREEAKTYSFFEYNTDYWKIRLGSPTLVYIADKSAKRKPFKLEEWSIHVEKSRHIKITWLDSEQVYEVACFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L696</accession>
    <name>U4L696_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative 12-oxophytodienoate reductase 4 acc. no. Q69TH8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935661">
        <property type="protein sequence ID" value="CCX11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L696"/>
    <dbReference type="STRING" id="1076935.U4L696"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PEKRCKF"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="398" mass="44782" checksum="33829B778F01DFD2" modified="2013-12-11" version="1">MASTIDRESSALFKPLTIGNGTLTIGHRVVHAPLTRLRGVAVREGTPEDPCREWMVDDMVIDYYTQRATEGGLMITEGVAVNVEAGSLPGIPGLFVPEQVQAWKKLVDAVHAKGAKIYAQLWHAGRTSVSLLIGSDALCASAVALEDEMCWAAGVKFEDYPPKEMTQEDINRTIEAFAKCAVSAVEEAGFDGVEIHGGNGYIIDQFLNSNTNQRTDKYGGSPENRCRFPLEIMESVIKAIGQDKVALRLTPFGLYNGTRGEQRLETWGYLCKEIKRQWELSYIHFIEPRYEQIIVPEEKEKFLASWGMPDITLAPFREIFGKTPFFAAGGYNDTNSWGVIESGTYDAIVYGRYFLANPDFVYRLRNGIKFNKYNRDRFYGPFPDRHVGYVDYPRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7J9</accession>
    <name>U4L7J9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Ribonuclease H1 acc. no. O60930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935434">
        <property type="protein sequence ID" value="CCX08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7J9"/>
    <dbReference type="STRING" id="1076935.U4L7J9"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="267" mass="30144" checksum="A655FED459A85127" modified="2013-12-11" version="1">MSLLRNVLTFGSTWPRPAAVKVPKSTNTVFDSRDWLRHFNPQSQLSDEPYENMEDVLFDCGTFIKVYTQPPFMPKYIDDDILMVKIGGAFVTPGIYDGPNPTPPRAGVGVYFGFGNFLNVSQPIDNIFEMIPGGIHTQLHIDIQAAVSAIDVVSNAWWIKNKMKNINRVVFGTLNAELINAICYNVTEWRKNNWVDQQGNKVQDWEQLNELDISIRNLGLEVQFWLIEGWNFEGPNLALNAVGLGQEVPNAPNPKLVANYDSVLSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7V5</accession>
    <name>U4L7V5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7V5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10141" checksum="C808C1827B0E02BA" modified="2013-12-11" version="1">MNKTGLHPLAERVEELEELCDQLLEENDRLHERVRQLEWAMVPADDGENQLEWVIDPVGDEMEIESDGVEMGNHGEGVSGKEAATNGENGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8A5</accession>
    <name>U4L8A5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935287">
        <property type="protein sequence ID" value="CCX06379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8A5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14954" checksum="6F9A2116E2CCA62E" modified="2013-12-11" version="1">MAVDKVVHVSYCLLLLRTPPRDELGKAQVESLTMRGEPLERPRLEPRLVCTMGTGKVKKGYGRRGEAKAGVRELCFMSCCGEASGLWSTSTDETSVRNGTRYDEQENQESEELRWLKLKSTSQIAKTQINSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8P1</accession>
    <name>U4L8P1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8P1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5901" checksum="32B8DD920A524981" modified="2013-12-11" version="1">MYHFRESLIERSRTKIMVSVGYWMPAYLRMLARRIRTLQMAYNRFISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L989</accession>
    <name>U4L989_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Diacylglycerol pyrophosphate phosphatase 1 acc. no. Q05521</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L989"/>
    <dbReference type="STRING" id="1076935.U4L989"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WFSYRRY"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="113"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="300" mass="33353" checksum="2E59530BD747CA22" modified="2013-12-11" version="1">MPATTRLKSKERAPEPGFTGAIRRMYTRAYGADWFGVLLLVLQNLALLFVVPFKRLFSLDDRRISFPHADPERVPVPQLLFYAAALPAIVITLYIIVAPSATAKSHKLHVALLGLTTSLLLAAFITDLIKNTVGRGRPDLLARCKAAEGTPLHELVDWTVCTETDHHTLHDGFRSFPSGHSSFSWAGLGYLGLFLAGQMAALKRGRGIGRLVVAGLPAVGAALITISRTEDYRHDVFDVSVGTWIGMGCAWFMYRRYFRALGDVKCEMPYEREEEEGEKDEDGFERLREVEMGVRTGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9I4</accession>
    <name>U4L9I4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9I4"/>
    <dbReference type="STRING" id="1076935.U4L9I4"/>
    <dbReference type="OMA" id="HNMERED"/>
    <dbReference type="OrthoDB" id="10382818at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="315" mass="34170" checksum="CCF0F61934797314" modified="2013-12-11" version="1">MGFFKRSKPAEKEKEAAQDANPYVAPPPPYQPPTAQQQAPPQQYGGYGSSSGPSNYGAPAAGSAPRPPAYQGGGGYGAPAGPSGGYGGQSSYGNQPSYGQQGGSNYEADEDEEVEEIKGHIRRTNQESLSSLQNSNANLDRMIGIGEKTLETLDEGNARIAETGQKVLDSSRMVDSSRKKTAEVHNLQGMMTFKRVYAGNTADPDREKNAEFLRQTKYNAQHRMPHIPSASDNQRPKYGASKYSEWDEEGDKAVNDQLDQTLAKMQGLNRLAKNINQSLDTSNQVIDNVTGLVQHTDRKIGGATNFLTNPKARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9Q1</accession>
    <name>U4L9Q1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX10417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9Q1"/>
    <dbReference type="eggNOG" id="ENOG502SV5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIPTKGD"/>
    <dbReference type="OrthoDB" id="4537670at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="18036" checksum="8D747738F2335EFA" modified="2013-12-11" version="1">MVVVVNAGDEILVPLYESGTKASTVQWSQNLSQRTAQYASVICDNMSTGEQVTLFIAAEYYKDSTIANANHISKIAEKIEGEGYKLKIDGRIQYGQKNAAGELRFIVYHDKERKPFQHRFVETAMASAAAGKASEIAKTLGGATGTAAEMAATVAKNFVGDYLRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9T5</accession>
    <name>U4L9T5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9T5"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651252" evidence="1">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="8491" checksum="41FAA68F4B1C355D" modified="2013-12-11" version="1">MRVSLAILSFLAAVASAYPADTKPSAAPANGRITMSPDGIPILSIPPEIKLKHAILSRSEVSALGLPPVPEMPGHLHDAIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAB9</accession>
    <name>U4LAB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAB9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651183" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8918" checksum="8DD9909537B694BD" modified="2013-12-11" version="1">MKFSILPFSLSFIFPSIVNGDELGMKIWMTTKAREAKAMKWTIWEDRCKPISEPMDNSITFVRPSSNTCCTFYKADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAE3</accession>
    <name>U4LAE3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935333">
        <property type="protein sequence ID" value="CCX07129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAE3"/>
    <dbReference type="OrthoDB" id="5395491at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651186" evidence="2">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="168" mass="16683" checksum="8AFE80B9AB0DF3B4" modified="2013-12-11" version="1">MKLVAALAFVLPVALAADFGSCAQENQCGYICCAEHEKCIMDYCIAPDFVKSALAGDAAASIYPSLADDNYRSSVMSAIASAPSGVESAYSKFVDVMTGAPSPTPLGTDIPSGYTIPSSLSVPAPTGSPNGTNSTGPAPIETSTGGSAQITIAMGAIAAAVVGAIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAU2</accession>
    <name>U4LAU2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAU2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="5121" checksum="ACF7F5E73FD19BFE" modified="2013-12-11" version="1">MLIRCISVPPPKVSEVKLVGCGDESLKPNEDNRGLEKRSREVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAX6</accession>
    <name>U4LAX6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935591">
        <property type="protein sequence ID" value="CCX11092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAX6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6720" checksum="20F73788A6E56C5B" modified="2013-12-11" version="1">MIGYRPNLSTNSFPISARHELLPAPRLLTDAGNLNSTSFSYLHREESLLRRSCDDRSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB21</accession>
    <name>U4LB21_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized transporter C1529.01 acc. no. Q9USN4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB21"/>
    <dbReference type="STRING" id="1076935.U4LB21"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SQVNWTV"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="72"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="530" mass="59087" checksum="39CC71B6F93DFACF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBB1</accession>
    <name>U4LBB1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBB1"/>
    <dbReference type="STRING" id="1076935.U4LBB1"/>
    <dbReference type="eggNOG" id="KOG0525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEAYYMA"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="405" mass="44158" checksum="15500D75DF4067F4" modified="2013-12-11" version="1">MNSARHILPRLKLPPAPLRGALIAIPSSQPYRSYSSHHHDTSKRKLNLPINYNDSTYLSHTPSSALAHPELPAGFASKTKRMNLYSAINDALATILSTDSKSLIFGEDVSFGGVFRCTMGLLDQFGAQRVFNTPLTEQGIMGFAIGLSSSGYTALPEIQFADYLFPAFDQIHNEASKWRYRSGGAKVFNSGNLVIRMPTGAVGHGGLYHSQSPEGFFLGMQGVKVVIPRGPAQAKGLLIAAARCGDPVVFMEPKILYRGAVEEVPVGDYELPLGKAQVVKEGKDVTLISWGTMLYTCEMAAKAAKERLGVDVEVIDLRTVHPWDKETVTNSVLKTGRCVIVHEASRAGGVGESVGAEVQERCFTRLEAPIERVTGWDVPMPLVFEPFIVPDVARVFHGIKKTVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBL8</accession>
    <name>U4LBL8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to UPF0554 protein C2orf43 homolog acc. no. Q5F477</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBL8"/>
    <dbReference type="eggNOG" id="KOG3975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LIGYYHT"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX16652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="321" mass="35958" checksum="2890995740B2A319" modified="2013-12-11" version="1">MSPKPEQFPLPENFPPTETLYFPPITPTVSSPLLFFLPGNPGLVNYYTSFLAQLSIAHPNLHILAASHAGFHPDEPQLHKGYSWKWGPQPWGLDAQVKMKTELLQFAVEKLGDKNRRVLLVAHSMGAYLSLEMITGLKKATKEGSKILGGIMLFPTVLEIADSPQGRLLMPLLGSRIVRGAASWAAWGFSWLKEWQVKMLVKILTGQDPEAAETTRQLVTTPHVVEQALVLAEEEMRRITTDRWEEEVWGCEGRMVYVFGQKDHWVAEKTREGIMAKARGGGKYVLEETGLKHGFCVSQGERMAEVVKVKGWINDIVGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBU4</accession>
    <name>U4LBU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936499">
        <property type="protein sequence ID" value="CCX16697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBU4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652121" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="121" mass="13454" checksum="0881C0CFAD2BC4BD" modified="2013-12-11" version="1">MKFISALLTLCILLLSSTTAVSATPVPEPLPSPLPPSGVTVAPNDAPRIQLTKVELYTYWNFQGAKMIREFEKMDDSGCQTLRKEFRRLTMSYKVSNGCCTFFEDDSCAAKMFTAKSREDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC75</accession>
    <name>U4LC75_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC75"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="27901" checksum="E575C8425A310167" modified="2013-12-11" version="1">MVSRRAKANRKVEGTETPTTEEFRKFFGCTPEEYQKFCEKADPVVLRDEGLLHDEGLKNQTNAAKQENTKMGRSIFKECFPEKEKRLPGNQREQDHMLRCFDIRRMRLVRRRKMWLNSKKPTPPTKAQEETLESPSARPLTRSGILVLAFPVNDASVTVPLNALAFPVVSDSFAVPPWVSASPARIMSGPIFPNASPTPLRPGQSLVNALDIEIRVTRPETPARWLGETAFTARMLLRQLYRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCE3</accession>
    <name>U4LCE3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ankyrin repeat-containing protein, putative [Penicillium marneffei ATCC 18224] acc. no. XP_002144344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCE3"/>
    <dbReference type="STRING" id="1076935.U4LCE3"/>
    <dbReference type="OMA" id="HERHHDI"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="19771" checksum="B5A4D0157CB70713" modified="2013-12-11" version="1">MSTLQQMSISVPGQLSQQSEKLSEIVSIVTEISTTSAEISKISTGVQELQSKFKEGELDKLLSWISPINPHERHHDILSKRLNGTGQWFIQMSLFQDWMGNEKSANSRNGSQVFGCYGKPGAGKSVLCSIVIDHLSQMLKNRSEKACVIWLYCDYQDEAQQTAEKLIGALLKQILHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCS7</accession>
    <name>U4LCS7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCS7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10529" checksum="889EE623C4775F59" modified="2013-12-11" version="1">MSHSILSIRLLQFPPIFPDWYVRLHTQPSGVRSLGCHRQVLYDLRRGPMGMLMEPFHSQLHLANHLDTGEYGPATTSRHISSPSMELQRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDC8</accession>
    <name>U4LDC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Mediator of DNA damage checkpoint protein 1 acc. no. Q767L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDC8"/>
    <dbReference type="STRING" id="1076935.U4LDC8"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17744">
        <property type="entry name" value="BRCT_MDC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="767"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="842"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="963" mass="105266" checksum="9A17A46D2507079E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDR2</accession>
    <name>U4LDR2_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935409">
        <property type="protein sequence ID" value="CCX29998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDR2"/>
    <dbReference type="STRING" id="1076935.U4LDR2"/>
    <dbReference type="eggNOG" id="ENOG502S71G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMMVMAS"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23118" checksum="241BAEB910C9E767" modified="2013-12-11" version="1">MALHTSDITTTTSTSYTSVEAGQRVVITRRAFRWPEISLSLILFALLCTGAITLGTYSYFASVQDRLHITNPWYYFFLIATGAMTVVFVLVSVILYYIHMLLPIPIIFCSFVLFVFWLTGLVKSSIELWGPMGSVNDNCVRYVYGDNTWGGATRETLARIQQEGMCNLWKTVFAMEMIACFCCLWLCLMAWQVNNAASIRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDW4</accession>
    <name>U4LDW4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDW4"/>
    <dbReference type="STRING" id="1076935.U4LDW4"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GTYAINW"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="559" mass="60859" checksum="A86CA8C4EA3F9DF8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LER3</accession>
    <name>U4LER3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LER3"/>
    <dbReference type="OrthoDB" id="5301632at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="847" mass="93222" checksum="C591EAE0AE030F57" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF07</accession>
    <name>U4LF07_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_08642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF07"/>
    <dbReference type="STRING" id="1076935.U4LF07"/>
    <dbReference type="eggNOG" id="ENOG502QSJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HKYVSQR"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="444" mass="48076" checksum="AF403CF5BEB1EA3F" modified="2013-12-11" version="1">MTHSDTETANSGGNGEAKYILSINAGSSSVKLSLYLTNHNCEPKTIITASISSLTSSPAKFTYQDHSSPKDPVTSDLDSVDSHESAFRHFLCQLEEQSFNPPISFICHRIVHGGSFTKPTILSSSTISELNSLSSFAPLHNAPALSLVHASLKALPDATQIAYFDTLFHSTIPTAVSTYAISRDVTGGVDQSQKDQDDPRPSLRKYGFHGISYIWILNSVAEYLHQPVSETSIIALHLGSGASACAIQDGKSIDTTMGLTPASGLPGATRAGDLDPTLVFHLMKPKETGKQKDVGEGLKITEAEEVLNMECGWAGMTGTKEFGEIAEGWIKGDKDMGLAFEVFVDRVVGYVGNYWTKMGGRCDALVFSGGIGEKSNVLRREVVRRLSCLGFRIDERRNGKLRDGTVVGIGGERVSDDGGRVLVVRTDEERMMARECARDGRFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFJ5</accession>
    <name>U4LFJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935539">
        <property type="protein sequence ID" value="CCX10393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFJ5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="16540" checksum="A1E6084004B50E18" modified="2013-12-11" version="1">MKTKTSIKPRVKNSHETHNTLTFLTLFTTTRSPLPNPKANTSPHHPVPNASHLHPSQYNPHQVYPTSYFQARIFPSPQTFFSLFPLPGVTTYFAPPHHDTSGTYPQTSSHSSTSHLYPSPPPPSAIFQHHVQRVIPVACKRVCVSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGG8</accession>
    <name>U4LGG8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to 60S ribosomal protein L6-B acc. no. P05739</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935567">
        <property type="protein sequence ID" value="CCX10829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGG8"/>
    <dbReference type="STRING" id="1076935.U4LGG8"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="193" mass="21348" checksum="00C1EA0FA62F99A3" modified="2013-12-11" version="1">MSAATKNVTFGSGSREVALNKAAKWYPSEEDAAPKKVRKTIRPTTLRPTLQPGAVLIILAGRFRGKRVVYLKALSNGVLLVTGPFKVNGVPLRRVNARYVIATSTIVDLTGVNTEKFDDKYFAREKETKKTKEEKLFKGDKVAKKETPEVRKADQKEVDAALLANIKKVPQLAGYIASSFSLSKGDRPHLMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH26</accession>
    <name>U4LH26_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Transcriptional repressor rco-1 acc. no. P78706</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH26"/>
    <dbReference type="STRING" id="1076935.U4LH26"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTPDANW"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
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            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="512"/>
        </location>
    </feature>
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            <end position="564"/>
        </location>
    </feature>
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            <begin position="565"/>
            <end position="600"/>
        </location>
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            <begin position="86"/>
            <end position="174"/>
        </location>
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            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
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            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
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            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX11327.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="606" mass="66418" checksum="393D79E2EBF61E6C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHN9</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9384" checksum="05BAB337A52E67AA" modified="2013-12-11" version="1">MTVPDTLLPHVPAVQCPVSLCSPPTSALFTVGFTDSKPRVVRAPRALRRAYKVTTSRFSSCQLSLCLFSGRCQHGKCLFFVCQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHU7</accession>
    <name>U4LHU7_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX16238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9856" checksum="1734054433F049DA" modified="2013-12-11" version="1">MLCCRGKEPSPSQEQHSKRRYARLSENVLEHRYHIHSFGDRQPRPPIESCEIKWGTTPVRFDGGTTLLVEILAIGLMVRWNDARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIC1</accession>
    <name>U4LIC1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LIC1"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="29084" checksum="106E4AF814C06B86" modified="2013-12-11" version="1">MFRNNYDNDSVTFSPQGRIFQVEYALEAIKQGSAAVGLVSNTHAVLIALKRNAEELGSYQKKIIGIDTHLGVALAGLAPDARVLSNFMRQQSMSSRFLYNRPVPVARVVNAIADKAQVNTQHYGRRPYGVGLLVAGVDETGPHLWEFQPSGMVLEYRGAAIGARSQSAKTYLERNYESFGDATREELVLHGLTALRDTLAQDKELTTANVSLAIVGKDEKFKLYDGDEVAEWLEKLGNTQSSRGSRGAAAAPPAPEAAAPAGDSMDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ07</accession>
    <name>U4LJ07_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ07"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10069" checksum="6CB72FB01E06E360" modified="2013-12-11" version="1">MSSSESKKSTAEGSNPAKEEQPAAEKDPGKTKDSGADKDATEETTTEDKDMRTEGWRETMEAAKKADPSTLTKGQSKGPDDDEDDDGPDVVPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJA4</accession>
    <name>U4LJA4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RNA polymerase I-specific transcription initiation factor rrn11 acc. no. O94332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJA4"/>
    <dbReference type="STRING" id="1076935.U4LJA4"/>
    <dbReference type="eggNOG" id="ENOG502SC4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHNERSA"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="309" mass="34876" checksum="CE6139EAED2E21FF" modified="2013-12-11" version="1">MDIPAPAFYNIPTRFTVDYRVPKRRRSNSDSSNASNAANSEDEFFTPAPSIASSFISPGALAPGEAPPPESPKKRHSRPRLQRELLAAHNLVPLPTTANKTMRQRNISVVTAILHRSLSDRNYAQAERAYGCLIRSKEIDICRIWGIGVQLLLHRSEDGHKIAAEFLEWLIVTFPYSQRLHGYHPALGKQRKDGKTTKWNKRDMAVDFMPELYSVMIQGGERPEKIREKLEALMLQPPWGDIHGLILLKGMVFLWSADCEEDEKAARRFRREARKCFKSLRDKGGDIPEGLEEAARAGEGEGDGGDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJE3</accession>
    <name>U4LJE3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_11200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJE3"/>
    <dbReference type="STRING" id="1076935.U4LJE3"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACRDWHA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="351"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX31677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="594" mass="63434" checksum="4D4E5F51A2525BB1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJL8</accession>
    <name>U4LJL8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJL8"/>
    <dbReference type="OrthoDB" id="5301262at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="953" mass="104744" checksum="6E13DF4469D987A0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJU3</accession>
    <name>U4LJU3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Transcription factor prr1 acc. no. O14283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJU3"/>
    <dbReference type="STRING" id="1076935.U4LJU3"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TNVDPGW"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="358"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="626" mass="68981" checksum="C018E6E413BEB368" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK46</accession>
    <name>U4LK46_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_13237</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK46"/>
    <dbReference type="STRING" id="1076935.U4LK46"/>
    <dbReference type="eggNOG" id="KOG2508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCILEQF"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="899"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118496" checksum="97B5CB0F58C403B6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK49</accession>
    <name>U4LK49_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Checkpoint protein rad17 acc. no. P50531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935806">
        <property type="protein sequence ID" value="CCX32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK49"/>
    <dbReference type="STRING" id="1076935.U4LK49"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PAMESEW"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="509"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="810" mass="89245" checksum="2E32330C8B227618" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKE9</accession>
    <name>U4LKE9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_13062</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKE9"/>
    <dbReference type="STRING" id="1076935.U4LKE9"/>
    <dbReference type="eggNOG" id="ENOG502QSD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNVKGCW"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="211"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="259"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="560"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX32413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="715" mass="78270" checksum="03EC014D86007C52" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKH6</accession>
    <name>U4LKH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein RF_0381 acc. no. Q4UMH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="5">CBS 100304</strain>
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            <end position="439"/>
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        <location>
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            <end position="943"/>
        </location>
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        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1171" mass="135588" checksum="2237E1CE19C3AEDB" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="2995" checksum="25FD9E1CDADB4188" modified="2013-12-11" version="1">MLHLTLLVTTSIMECMASPVFNKLCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLA8</accession>
    <name>U4LLA8_PYROM</name>
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        <submittedName>
            <fullName evidence="5">Similar to RNA and export factor-binding protein 2 acc. no. Q9JJW6</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
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            <end position="287"/>
        </location>
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        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
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            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
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            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="250"/>
            <end position="277"/>
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        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="324" mass="35367" checksum="C7C90D2EABD71882" modified="2013-12-11" version="1">MDKALDDAVRERHNNGRNNRNNQQRRGTPRGGVRKPGRNTNGSYDDSRLWVHDKFNDGDSNDRSRKPMARDFPIKGMAPSTGAKVKVENIHYELGEEELMDLFRRQGPVVKLDLLYDRAGRSEGTAFVTYAHEADALSAIKAYDGANANGQPITLTLVARDRVERGPSSVNSAQSRPRSLFDRIVPQDGPGGPRERRRSLDDRRDPTRKPTPPGIDRYVPPERRRERERGGGERTQAGPRPAVGHRDGGRGQGRRGGPGGHGGPGGNGERGGRGGNMGRPKKTVEELDAEMNDYFAESADAAAAPAVAPPAQAAAVDEDEDMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMM7</accession>
    <name>U4LMM7_PYROM</name>
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        <submittedName>
            <fullName evidence="6">Similar to Pachytene checkpoint protein 2 homolog acc. no. Q6P4W8</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">PCON_08937</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
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    <dbReference type="eggNOG" id="KOG0744">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
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        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="209"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="474" mass="53308" checksum="C180AE522605D06A" modified="2013-12-11" version="1">MRSTSLISRVFLFHVHAPCSSISKFSHQKRLRSQQHHLRQLANMTTHRTLSQTRVLVHLEALLLSDCPRYSHETLTSAILQYIHANFETLSLDDEFYSFDDDYLETHISKLTVADLVGNDSEDIVSLSNCQIEVHIYKLHTLAGTGVLRLEGEDKPTPVFRATDLPAESLAGLWDGLVYEGNIKGRLLAFMMTALRFSGREREMRTMSFNRLVLLHGPPGTGKTSLARSLAHKVAIRMSKQYQRIQLFEINSHSLFSKYFSESAKRLGQVFDHFVKQLADSGLFLVILIDEIETLAVSRNANGSGAEPKDAMRVVNVLLTSLDKLKAKENVIVFTTSNLIQHTDSAFLDRCDIKQFIDTPCIPAAYSILRNCLDDMIQAEIITPIEEPLPCATEASLYLHALPDAPQTKLWRIATKCAGLSARTLGKLPFLMHAAYIQRENCNMEEALEALEKTVDDVLEDKKGSSETRHPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMN5</accession>
    <name>U4LMN5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Syntaxin-like protein psy1 acc. no. Q9USH7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_08942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935458">
        <property type="protein sequence ID" value="CCX30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMN5"/>
    <dbReference type="STRING" id="1076935.U4LMN5"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VLHASHY"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="327" mass="36272" checksum="B45DFF55E31404F8" modified="2013-12-11" version="1">MGNMNAGADQGYAAAPAGNDTQDFYQEVDDIRSGIDNANANIARIEQLHGRSLNDIDEAAQQQTQRQLEQAVAETSALNKDLVMRIRVLKGKAVNDPSMAPQINVLDRNCKEMLRKYQLVEKTFVDRTRDQMARQYRIVKPDASDEEVQAACDDAAGTQIFSQALLNGNRRGEARSALREVQARHNEILRIERTIMELAELFEQMEQMVMEQHVMVEAIAERAEAVHRDVVKADEELGQAVDKARSARRKKWWCLLIIIAIIVVIVIIVVIVVLLNQRNNNNATAPAATVTATPTPTVTAAADGAAAPTATKTPEPQVARRGYYLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN13</accession>
    <name>U4LN13_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized transcriptional regulatory protein C11D3.07c acc. no. Q10086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_14002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN13"/>
    <dbReference type="eggNOG" id="ENOG502S2DS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFGRSTC"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="748" mass="82738" checksum="CB2CD71BB8B01ED0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN19</accession>
    <name>U4LN19_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_14007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
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    <dbReference type="Proteomes" id="UP000018144">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="18"/>
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            <end position="214"/>
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            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24556" checksum="BA6E69D61D8A7794" modified="2013-12-11" version="1">MKINTPLLLLFIPPTIYANNLENTFANETMKKIDINCRHEGAVKVNCTGLDSTTTCICSHKNLYKEAFTHFCEEKYDIPDHLAREEREYTEWRCNRYHTDDELWFDPLLEVEPIESEQEVDIVGVILGVVFGVMVVVVIGLWCFWLRIKKQRKEAEGLVAHLKASSGDIEMNGMSSEILGREYFATIVTREESPWNVQAELAPARGENEEEAGR</sequence>
</entry>
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            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="8" mass="888" checksum="FE2731B76735B446" modified="2013-12-11" version="1">MNSLPTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LN52"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="126" mass="14317" checksum="7103CC9DAA6B0D44" modified="2013-12-11" version="1">MANEAPEVTIEQLPRHLHKALKALERIIGAYRILKTGSYASDSMIENYENEEIIGSIEKLGLTWDDKYMNPACTPSSHPSVKPILFQEILKDVKAKLDAEQAAKPVWMSTMFSFYTLHRSRHGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPC0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03123</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LPC0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6721" checksum="44DE9A683235BB51" modified="2013-12-11" version="1">MGLVFRNCREFGISCLASVTVAISSLLWICMREPQQPVQGLAMHPTLTAPSLVCESLDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPI2</accession>
    <name>U4LPI2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized WD repeat-containing protein C9G1.05 acc. no. O14301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01329</name>
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    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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            <begin position="54"/>
            <end position="95"/>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="189"/>
            <end position="230"/>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="232"/>
            <end position="274"/>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="577"/>
            <end position="615"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="615" mass="65889" checksum="FF5C22A6C207C827" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized transporter C1039.04 acc. no. Q9US37</fullName>
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        <name evidence="9" type="ORF">PCON_01339</name>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LPJ2"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="509" mass="56181" checksum="717C6FBFF9F8AF18" modified="2013-12-11" version="1">MEAKDQDLMHLENGMEKNLAALDAQDLQGELDSLDREMEAVMRKKFDYTILPVVTLIYLMAFIDRSNMGNAKIMGMEEDLHLKGYDFNIALTGFFVTYVLFEVKELSTDILWDNFVRPANVLCKHFGPRVWLSLITLMFGIITLCIAFVDNKKGLIAARVCLGVAEAGIMPGITYTLSTFYRRHELVTRVGIYASVASVAGGFGGLLATGFSLIPQWGMVHSWRNIFFFEGVMTIGAAIVCYCALPNSPGEARFLNKEQQVLGVRRIQLEALALATEKMQKRHFTAAILNFNTWLMSIGLFCSLLCMNSVALFMPSLLRAMHFTSIKAQLMTVPPYVLGSIVCISAAITSDRFKTRGTVLLALACPTIVIGFALLLSVNIIAVKYFALFLVTMGAFTGSPVFISWTVDNSAGPTVRAIASGFAVSLGSTGGLVATWTYLPSEAPGYTTGHIINLCAGIVFFLVTAITTTYLRWENRMRDQGKRDYRVEGKSEEEIATLGHSHPAFRYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPS8</accession>
    <name>U4LPS8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized protein YOL098C acc. no. Q12496</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPS8"/>
    <dbReference type="STRING" id="1076935.U4LPS8"/>
    <dbReference type="MEROPS" id="M16.A04"/>
    <dbReference type="eggNOG" id="KOG0961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CVEGPFW"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118983" checksum="4A04D77D620FB03B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQD0</accession>
    <name>U4LQD0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936658">
        <property type="protein sequence ID" value="CCX17486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQD0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="255" mass="26485" checksum="F2B45BEC5104A0C8" modified="2013-12-11" version="1">MNQILRSSPLDFPPFDSTCGTTTDPTAYLFSTYHYSTPMPPGAVIPAIAAHATALRKPRRKLLSKNVAASASAAVDSSAAASAEGSLPAADSRKCRWNINPVLLNLNFVPAPVSSALPPIPTSVPAAVTAFQAPGQAYVASGLSGAPAAAQEKPKRKHSSKEPASLTAYTAPDSNASTARAAPATAPKRLKSATNTSISSAADQSAGNDDDYDSPMAPEDPDWDMWIWLPSTTKGGPSAKQILVAGKLYWKAPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQL6</accession>
    <name>U4LQL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQL6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="7118" checksum="4FC85650D0E515DA" modified="2013-12-11" version="1">MCVCRFSFFEPLISSIVNSRFLFYRPVLLSSRRAAGYCKVFGEWSSCDSSQKDKTSSCNYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQN2</accession>
    <name>U4LQN2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_02101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQN2"/>
    <dbReference type="STRING" id="1076935.U4LQN2"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KKWIMRA"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="209"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1063"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1101" mass="118022" checksum="61817710155D3C17" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQZ2</accession>
    <name>U4LQZ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936526">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S5M8">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <dbReference type="GO" id="GO:0005681">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
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            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
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            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
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            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="308"/>
            <end position="321"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41271" checksum="B83C853FDA419C63" modified="2013-12-11" version="1">MSDEIQTPDVTTPTVDTPMNEAEAPTTTAEPPSTEPPTAAAEIPTAETPVADAEPLPTFTAPRRRNLAKFRRRKSLSASPEPDTKPSTTDAAAESTTAETSQQSALQRPRRPARRLGLEVSAPKTLPTSEAPSDPDSEARQAELEALAVVNRFTHQTGQIENVDKHMMAYVEFEMLKRRGEPLPTRSSPTDDDSAGGREGGSGGQGSYWVPTRPEARGATLGKLHEVDLGQEARERNIALTAAALNGEPLPSSSDPSATSNSKRSRKRRSSQDVERDRLVEEVLKETRLDLYPEESEQGESEEEEGAADDKIAEKFRREFLDAILSKRRRRGQDSKAGAKTGAGKKEDKKRPKGPKLGGSRMARAQMREQQGGAAGQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT47</accession>
    <name>U4LT47_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="5313" checksum="814FB542BB517126" modified="2013-12-11" version="1">MESKQSMADSNRSRTYNITRFDSGVRESNCLEVLLRGAISRRAENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT61</accession>
    <name>U4LT61_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_08933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935458">
        <property type="protein sequence ID" value="CCX30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT61"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5733" checksum="4A84F027B206C240" modified="2013-12-11" version="1">MPLRFNIRRSVRYQKKSFVVRHDHNASVNGATELRLILRNYRAAAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTT2</accession>
    <name>U4LTT2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTT2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8851" checksum="B20CB9D28969DE53" modified="2013-12-11" version="1">MHALSGSKDALEDADAFKHAALDLFEWYSILYHHLYWIHCTAVPKKGNTDLLRSRLPPASVPCISCTKKKTVVVLNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTZ4</accession>
    <name>U4LTZ4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTZ4"/>
    <dbReference type="STRING" id="1076935.U4LTZ4"/>
    <dbReference type="eggNOG" id="KOG2896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYRFEYG"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="595" mass="65108" checksum="204CFACE79DBB7DD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU23</accession>
    <name>U4LU23_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative nuclease HARBI1 acc. no. Q8BR93</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU23"/>
    <dbReference type="STRING" id="1076935.U4LU23"/>
    <dbReference type="eggNOG" id="KOG4585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRIWENS"/>
    <dbReference type="OrthoDB" id="5340790at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="111"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="259" mass="29500" checksum="EA19E985C632F9AB" modified="2013-12-11" version="1">MDRENFERLLELIVDHEVFKNRSPVAAAQQTHPRYQLAVFLLRMGGGSKSGSMTLVLAATAAGVGEGSIVNISRRVPIAILSLHDTFTHWPTREEKAVLKQCYAPLENWWYYFSRKSTYALNAMVVYSDQRKILYVKASDNSASHDARIFDGFLLHQRHQDFFEHGEYLIGDSAYTATDRMVSLYKQPYPSAAHAVFNSTLCAQRIAIEHTFGILKARFPSITNMSIRIQGHESHKACVDWFIGACILHNFLRDVDDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU81</accession>
    <name>U4LU81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Zinc finger protein 567 acc. no. Q8N184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936097">
        <property type="protein sequence ID" value="CCX33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU81"/>
    <dbReference type="eggNOG" id="KOG2462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNMFARK"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="40810" checksum="B87E095B02FBF512" modified="2013-12-11" version="1">MSNCRSIEYISPQHSPDIRHNSDPCYPESHRTECDRPSEPPLHPDYHSYSVQYPAFHPNNAPLSPPASDGIMSPPLPGLEFAKTQMTPHMHWNHQNSFPIKDDPTYASSRQTPPTMFIEDIFQQDPNVMEQSYIDAQGVKRRVRDIRDVYLGMAPGSGSEYSSGASMGLSPSPSLYHGSQGMQETPRRKKRHLTEPAEANYECNECGKLFSRVWNYNAHLDTHRPDRPRPHVCPEQDCGKAFVRRTDLTRHTQCVHQREKRYRCELCNNMFARKDTLRRHEDDGCSKRVDIVSRHAKNRPMTIQSTALNACLAEMGQKQQPQQQLFYSQYDQLPQGYDNGLPPLSDMVRIEKTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUG1</accession>
    <name>U4LUG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Plectasin acc. no. Q53I06</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the invertebrate defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUG1"/>
    <dbReference type="eggNOG" id="ENOG502SVYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187789at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00107">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0211">Defensin</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652391" evidence="4">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="5">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10308" checksum="FC52374580C4D919" modified="2013-12-11" version="1">MQFPTILTVAIFGLLNISALAAPQPVEEAHGEIFNPDVQLDADTNADDSSHLAKRGFGCNGPWDEDDMKCHNHCKSIKGYKGGYCAKAGFVCKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUK9</accession>
    <name>U4LUK9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUK9"/>
    <dbReference type="STRING" id="1076935.U4LUK9"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIRGETW"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000049">
        <property type="entry name" value="RNA Polymerase II CTD phosphatase Fcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="155"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="479"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="575"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="640"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="925" mass="102110" checksum="802580F0F7E1263A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUZ2</accession>
    <name>U4LUZ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUZ2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8429" checksum="6987B56AB4650394" modified="2013-12-11" version="1">MAPYLLYTNAKSALGPQVPTAQTHISRLWILQYHTTTKKCCQKCCHFMLTLRYTYPVHSRYHSSQYSAHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVR5</accession>
    <name>U4LVR5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVR5"/>
    <dbReference type="OrthoDB" id="10352061at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13226" checksum="FCA40A8F3F0D6A3F" modified="2013-12-11" version="1">MAPPFDITPSLQHNIAPPPPPSAFTRFLFKLLNLFLYVSFYALIWVFWVNGFTDAAILWAMGPILGTLWASGVMRLADKVICGVIKPRPMLAMMKRDETGFLAALRRRREEMSGVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWT1</accession>
    <name>U4LWT1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWT1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9768" checksum="EEC3E7175FBCD029" modified="2013-12-11" version="1">MRPQFLQWSNPQNLEFTARIKSPIAGCDSKRSSFYLEQSLAAQFPFIFTPSKRAAVDRRRGGFEVQEDAEDSTWGKKTVRQRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUU1</accession>
    <name>U4KUU1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to DNA-3-methyladenine glycosylase acc. no. P22134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUU1"/>
    <dbReference type="STRING" id="1076935.U4KUU1"/>
    <dbReference type="eggNOG" id="KOG1918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TSELICI"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="174"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="342" mass="36536" checksum="C86D3AD0BEDD118A" modified="2013-12-11" version="1">MAPTTRRAAAGALTHLKASKSRGVTKKSSTSKLHTTTASTNASNAGLANASTSRSPMPRSISTEDIRSDFAIPQTIPISELETLPASSRKIVPTATTVPLLISNDATTATIAEPIASSSATASTDNILSKALSHLIQIDPRFAPLIEKHPCPLFTPGGLAEVQDPFASLCSGVISQQVSGAAAKSIKAKFIALFTDELHGGLFPSPEMVLRKDIPTLRTAGLSERKAEYVLAVAQAFVSKQITAELLAAGTDSEVTSALTAIRGIGQWSAEMFLMFCLRRWDVFSTGDLGIARGMAAFAGMDVAKLKKGKGKWKYMPEKEMKEMAERYRPYRSFVLLVYVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUW2</accession>
    <name>U4KUW2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUW2"/>
    <dbReference type="OrthoDB" id="7791461at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651647" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9109" checksum="B0D302569A88B393" modified="2013-12-11" version="1">MQFSTIAVVLACASSALGAAVGVCPPWRDDAHTLLPDAEDCTVFWKCNPWGPVKIECPKGLYYATQHNWCDFKENAICYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUW8</accession>
    <name>U4KUW8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Ring assembly protein 3 acc. no. O74994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935219">
        <property type="protein sequence ID" value="CCX04897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUW8"/>
    <dbReference type="STRING" id="1076935.U4KUW8"/>
    <dbReference type="eggNOG" id="KOG4151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCNLMTC"/>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="5">
        <location>
            <begin position="223"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="808" mass="87962" checksum="E323758818950FAA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVD6</accession>
    <name>U4KVD6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Transcriptional repressor XBP1 acc. no. P40489</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVD6"/>
    <dbReference type="STRING" id="1076935.U4KVD6"/>
    <dbReference type="eggNOG" id="ENOG502S1IW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="78"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="526" mass="59920" checksum="3B2053D72FCDF039" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVP9</accession>
    <name>U4KVP9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVP9"/>
    <dbReference type="STRING" id="1076935.U4KVP9"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYKHDEA"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="113"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="580" mass="64550" checksum="D3AC783012C40641" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX46</accession>
    <name>U4KX46_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX46"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13152" checksum="C9E1B5F3FE12E993" modified="2013-12-11" version="1">MQNLSYRLTLAGIHWAAPFRSFGAARLDSCPLSRGSGRGTQKLPIFSFPDLKGAQPQATLRAHSTLTGLRAPLHPIWPSGASMNFNKAARPSFSVPQDPYSGRFLGSSLPPFFEAAPGLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXF5</accession>
    <name>U4KXF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CEN-like protein 1 acc. no. Q9XH44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4KXF5"/>
    <dbReference type="OMA" id="CTSKIAP"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650929" evidence="1">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="441" mass="45745" checksum="5DB7CA3E8EFCD1E5" modified="2013-12-11" version="1">MMFPNYSVLATTLLWISSALATNHKGIPQAFSTGFDPQSGLQISYDTVGTAAVKDGQDLSGKDLSKVPKFALGESSGINTNAKFIVLMIDPDVNGNPDVVAPQTLHYMRTDFQPSGQAVSIVSESAPAVKYVGPEATTGGNGTAHRYVFLLYSQPKNFKLQGVDANQRMGFDVKKWRDLNGLQPAIAGVHFVATPGVASVVPPATTTCTSKIAPVPSAPAVEVPTVEKPSVGGSGPQTIIHTVTVTADCACATAPAPPVGGVTLTAAPPTATAVTPPAAAVTHKVIVGGPSGLVYTPEFVQASPGDKVVFDFLARNHTVTQSTLENPCVLMPGGMKSGFRANPQSILGKETFEVTVTDTKPTWWFCAQAQHCQQGMVFAINPAEKFPTFKQNAMTGTNVTTPIGANATTPNLPVFTGAAAGLNAKVVSLVMGLAAAMVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXH0</accession>
    <name>U4KXH0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXH0"/>
    <dbReference type="STRING" id="1076935.U4KXH0"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YANVRTN"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="888"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="352"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX06185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125453" checksum="A7A27F19FA0B5A0E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXH2</accession>
    <name>U4KXH2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXH2"/>
    <dbReference type="STRING" id="1076935.U4KXH2"/>
    <dbReference type="eggNOG" id="KOG4844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="18736" checksum="EB6E19BB222D06DB" modified="2013-12-11" version="1">MASVARSRLLELKKVTASIFGTTFNPTGARTGNKILRQRLKGEALKDYYLPKLVSIKMLRKQWPDMDFVDEDEEMRLENVERAKSRGKGAPKKLRNEVTPPYLLSTVETTMAYQYLISRVADPIFAVFIGGSAAVLRIKREEQEAGRDMTQVVEIFKRRVGSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXQ9</accession>
    <name>U4KXQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935328">
        <property type="protein sequence ID" value="CCX06952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXQ9"/>
    <dbReference type="STRING" id="1076935.U4KXQ9"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="127" mass="14210" checksum="7AFE7D4650222A3D" modified="2013-12-11" version="1">MKLSINRQNLTIASLENRVAILTLVPEEYDLLRQRFLSKCKQKVGNAVAHGGDAVADSRLYLKSKRLDGEIFRELYGLDVLVVPLLSTEIISVLNLFFFFTICSTSLFNSSWSRNLAKPFSPLAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYA6</accession>
    <name>U4KYA6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYA6"/>
    <dbReference type="OrthoDB" id="10350785at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="287" mass="32366" checksum="977A98AEED501BAE" modified="2013-12-11" version="1">MTIADIKPTFIMTISNTKKPNSTWTPVFSRLLNRWIPPFILFIISDQNLIQLALLIQKQDLESKATKLHPLDAAYLTIIAREFQFLYAEAHHANQLIDTSHATCSSILQLLSDVLKDERNTFFQTLAGLFGYRFPYSFVEHGVPPKVMELYPKVTELRDCFIKAITLKAVAGVLLMAEDKAVVSDDAFEEIGSVTVDTRHLLLGELVANNMGVYEQMSTGAYDGVEVMEALKGAESLVEEKLGVFWWLKESSKPEVPKFNEKAVEEAILEETEVLGQVWALKRVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYE2</accession>
    <name>U4KYE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Oxalate decarboxylase oxdC acc. no. O34714</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF935296">
        <property type="protein sequence ID" value="CCX06565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYE2"/>
    <dbReference type="STRING" id="1076935.U4KYE2"/>
    <dbReference type="eggNOG" id="ENOG502QQ0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWHPNND"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651170" evidence="5">
        <location>
            <begin position="18"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="143"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="317"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="551" mass="58522" checksum="836A2482144ED16E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYY0</accession>
    <name>U4KYY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Uncharacterized mitochondrial carrier C27B12.09c acc. no. O13660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_06800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935341">
        <property type="protein sequence ID" value="CCX07211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYY0"/>
    <dbReference type="STRING" id="1076935.U4KYY0"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX07211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="32149" checksum="2B539BC5D8CE365C" modified="2013-12-11" version="1">MSKPPETVKKKGLGYPSSVVEPCAGLTAGLLSTLVVHPLDVIKIRLQIDRTPGVNKFGTSYRLLKNIHKLEGSLYRGLGINVIGNMSSWGLFFFLYADFKKRIAAKDGSVSDIGYWFTSAAAGVTTAVITNPLWVIKTRMLSTAASTPGAYPSMMQGFETIYKSEGARGFMRGLIPSLVGVTHGSFQITFYEKLKDWRMRNLAEGEELTKLDTICFSASSKIGAGMVTYPAKIIQSRIQAERGAIGPLEVCRQLYRVEGPQAFFKGLAPNTFRVLPATCITFLTYETVRNHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ06</accession>
    <name>U4KZ06_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ06"/>
    <dbReference type="OrthoDB" id="10326329at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="209" mass="24493" checksum="900A5BA667291163" modified="2013-12-11" version="1">MSQFSYDKAMRAYNAVKASKGDRPPTPDPAPAMKNIPFIAKSDILDLVEEGLLTWTELIELKVLIWLCHAGLYESVAPDYNTKAFELEQVLESLDNTMSTRSLKERAEDQCAFIKIQEEQEGLYKMAINTEDSKKRLRELIKLYDMDENEDRAYRIVEMFDNCVFKCMSKQDWMDWMEDYKLDTEKKLKKVREGKMDPEIEYALNQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ64</accession>
    <name>U4KZ64_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Protein MAK11 acc. no. P20484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935330">
        <property type="protein sequence ID" value="CCX07005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ64"/>
    <dbReference type="STRING" id="1076935.U4KZ64"/>
    <dbReference type="eggNOG" id="KOG0294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KLHQMKY"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="490" mass="53207" checksum="2390CFA1D747E010" modified="2013-12-11" version="1">MVKRKRGDVTGTTPALLPSANVTPMHPDTIHLQIITGTYEKTLHGFIASIPPLSSDSTTGDISLPTTFTDTFLFSAHTSPLKTLAISPAAPNTKKRILATSSADERINLYNLSTYLPPISNSSLAPLSGRNRHLGTLHNHLNTPTALLFTPSRNKLLSAGADGQIQILRTRDWGVLSTLKVPKPNPKPINYAKDYGEGYGPRVPTFGSEGYGGGAGAVNDIALHPSQKILLSVGSGERAVRMWNLMTARKAGVLAFDRETVPSKFGNEGQHIEFSGDGESYAVAFERGVVVFGMDSKPRVRIETKPRATKIHMIRYVSLPKQLLGQEEEEVLVVSTEDGRVLFFAPNAEVVDEPKLLGTLGGRRMGMMGRVKDFSVVQTGGRVFVITAGSDGVVRIFDLCGEGSGIEVEEGETETAKKTKEEKPTEEVKVAGDRQVGKIVGIYETTRRITCMATMIMEEGQEVEQEDEEMGEAGQEESSEEESTDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZH1</accession>
    <name>U4KZH1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_04676</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZH1"/>
    <dbReference type="STRING" id="1076935.U4KZH1"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="211"/>
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            <end position="369"/>
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            <end position="433"/>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2V7</accession>
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    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
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            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        </location>
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            <end position="334"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <source>
            <dbReference type="EMBL" id="CCX06583.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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    <protein>
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        </recommendedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
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        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
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        </reaction>
    </comment>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
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    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:GTP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:UTP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside diphosphate kinase B"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
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            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9371" checksum="7FB243F9F042E563" modified="2013-12-11" version="1">MNSGPICAMVWEGRDAVKTGRVLLGATNPAASAPGTIRGDFAIDVGRNVCHGSDSVENAKKEIALWFKPEELVSWKQASHNWVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L379</accession>
    <name>U4L379_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L379"/>
    <dbReference type="STRING" id="1076935.U4L379"/>
    <dbReference type="eggNOG" id="ENOG502SSFP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VICVCIP"/>
    <dbReference type="OrthoDB" id="5273647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="59"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX04500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="41794" checksum="CA2135F151E37251" modified="2013-12-11" version="1">MATPAASGVPAPPPQFPPGWIFAGSNISQPIPADQLAKSEGMEAGCYVSFAIAVLFVAARIYARCFIVGTFGFDDFFLILATLMSLAIIVCVPVMFNYGIGKHLIYVREADYFIGRKWAWISQIFYYAALGCVKCAIVALYHRLASQKLHKFLLKIMGALVLFHGIAAVITTAHMCNPVSIIWGPTFPNGCIDLLSFNYFNAAFHIATDIMLALIPIPILKGLQINRRKKIGLVIVFGVGALTILGTIARQVTNAMALGNFDFTWYWSAAELCTCIEVNMALICTSVPALRPLVKGFLKSTNGSSDPDNSYQMKKRSKFTLGSKLENGELKNQSNGGYSARIFSSAGKKTELNSTHTGNGSEEHIVPPSGMVKNVDYSVEYSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3R5</accession>
    <name>U4L3R5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3R5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9472" checksum="3A0C14808C27197C" modified="2013-12-11" version="1">MTANFDTPASFDSCTNIARISYCFEFMRPRLCVQKMIVVRFSEFRIDEFNRRFNKFLSNLYLCATFCGSHPQLKAEIPQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Y7</accession>
    <name>U4L3Y7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Y7"/>
    <dbReference type="STRING" id="1076935.U4L3Y7"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="447" mass="49186" checksum="C2ED273FB63FB07A" modified="2013-12-11" version="1">MTSQMVDIHTPGLKWWLTHLETEFHSTDSVDRYIDVLKRRSIRNPTPAAVGTAQLCLRLIGSHKFTTIGNLVEYVLNIEAKLSTARPKEMSIRNMVRRVLGIIREEAENNGQLAMFNAAMEASEAREEAPKTPSSASRPTILTSHASFAGTNQAAMTSLFNIFNVHSPQVLSTATTPLHSGVNTPVQHLPPGTSPHITKDIKPAVMQDIRELVDELESSDSAIAEFGPQLLPRNEIVMTYGLPPLIHKLLLKAAHKKDHDFTVVVVEGSPNIMKQTHAAFMNMGSLSDEDEEAEEQTAARKSLQDRGVQMILIPDSNIYNFIPRVNKVLLAANYVLADGSVVTTSGALNLARAAKAYSKPVVVLAGSHTLCPVTTYNPENFVEYGPPPTISSDDDDLLSMADFPNPLQDFIKPDFVTMFVTNNGINPKETINRTTLDLYHMTEPDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Z6</accession>
    <name>U4L3Z6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1348-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935543">
        <property type="protein sequence ID" value="CCX10454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Z6"/>
    <dbReference type="STRING" id="1076935.U4L3Z6"/>
    <dbReference type="eggNOG" id="ENOG502S04W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRFQYEC"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18849" checksum="A83DF28B4524C399" modified="2013-12-11" version="1">MSHIFPPFTAETAKAKVKAAQNLWNTKDPARVALAYTPGSIWRNRDSFLKGHDEIISFLSKKWEKENGYRLRKELFAFTDNKIAVQFWYEFYVDSEGDNEDKKGRKWFRCYGLEDWTFCEDGRMEKRQMSGNDVEITEEERWFKEGVDVDSVEIGAEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Z9</accession>
    <name>U4L3Z9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Z9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651017" evidence="1">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="14685" checksum="56C2D3366FC78406" modified="2013-12-11" version="1">MGFLLLLIPFGTKKSATLPLAGAALSAIAGSGATVRPRLMQDLPAAPSKKTIQSNQASVAESRGILASTATAKESRTSVTAQAMDKLLFRYGEHRGEWESIITAASEMFEVLAKADVFLRYRGGALEGKWSWNQVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L414</accession>
    <name>U4L414_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_06635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L414"/>
    <dbReference type="STRING" id="1076935.U4L414"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHLTYIK"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX07048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="889" mass="99825" checksum="52AAFA4D3043481C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L460</accession>
    <name>U4L460_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L460"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="6961" checksum="802924C2BFF296F7" modified="2013-12-11" version="1">MKHKKMKACGKSGSYSEMDLSQQSSQARELPGHGTLSPHPRTILHSAGRTPGEIEDAFVKEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4L470</accession>
    <name>U4L470_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Chromatin remodeling factor mit1 acc. no. Q9P793</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_06670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L470"/>
    <dbReference type="eggNOG" id="KOG0383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWATEDG"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4R3</accession>
    <name>U4L4R3_PYROM</name>
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        </recommendedName>
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        <name evidence="8" type="ORF">PCON_11107</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX11513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="315" mass="36855" checksum="ACF2D9BEAAC1DCA8" modified="2013-12-11" version="1">MKPHLLLPLLLLWLSPAIASRGDDLQEFKDCVSNCITTNCDSPTPTTIPLHLRLLLWTCPQECDYACQRLITSSRITSGLPVEQFHGKWPFRRLLGVQEPFSVLFSILNGLAHYRGLQSLRSELPRKYPLMTYYTWFSYIGMICWFFSALFHTRDFIATERLDYFGAGANVMYGLFYCPIRIFRLYRPSYRHLIKPWAYLCLACYLAHVYYLQFVTWDYTYNMAANVVVGSISNLLWTWFSIRQYGKMKKVWAAWPGLIVTWLILAMSLELLDFPPWGDALDAHALWHAMTILPAVWWYRFLVRDGRGNVEWGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5B9</accession>
    <name>U4L5B9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Isotrichodermin C-15 hydroxylase acc. no. O13317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935661">
        <property type="protein sequence ID" value="CCX11986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5B9"/>
    <dbReference type="STRING" id="1076935.U4L5B9"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HETTACG"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX11986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="526" mass="59464" checksum="F7A0DA36B2B9360D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5Q1</accession>
    <name>U4L5Q1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5Q1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5406" checksum="38AECEA3CD82FB99" modified="2013-12-11" version="1">MAGNIVQPTMATAHPPGALLLLHVFSRTPSILHPHQHALHPTSLRLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6E2</accession>
    <name>U4L6E2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6E2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14248" checksum="C0DA52D088C9C608" modified="2013-12-11" version="1">MLLLGNNSIYNPDQSTIEGFLMDLDGSNAVFQQGNPDALFPNASNPWPLDSRNQQIYCGGRSMYDQVSAHDSYVHHSGPHKPAGAFSPAADQQDYREFSDSCDCTLHHYTNANSGHASPHGYSLDEDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6T7</accession>
    <name>U4L6T7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6T7"/>
    <dbReference type="STRING" id="1076935.U4L6T7"/>
    <dbReference type="eggNOG" id="KOG2846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PKWYDRI"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="274"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="395" mass="43689" checksum="00EC8792C5A3EC1D" modified="2013-12-11" version="1">MLRFWPFGDDNSPDSFERILSQLSTKIERTSTKLTILRQAWRRFKALFTLYSVIGYIIYVIIVLLVIGRQNVGLYELGGLISSPIVIYSVRSLLDLYYGKRIAAAESRLEDLQMEQRTTIEKLKAATKYSTTQSLIEKYGGAPASPSFSDMNVSRRPSVASPAGPIGRPQTPQNPPQAPRGSVSPSQPQQPLPANAPVLSPEQIRIQQQLLAQQKAGIPPQFGGQSPVTPPQQLKPSTIGAPQQPQGLGIVPLPTTQPPSQQHIQPEEATAPKWYDRILDVVLGEDETSAKNRFALICRNCRMVNGLAPPGTRSLDDMEQWGCARCGKMNGGKKKKIVLSETESEAEPVRRAPRITRSRVKREDNEDEGEESDDESVRIDGEEEGGGVRRRARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6Y9</accession>
    <name>U4L6Y9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Glutathione S-transferase 1 acc. no. Q9Y7Q2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6Y9"/>
    <dbReference type="STRING" id="1076935.U4L6Y9"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KDPEYTS"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="27277" checksum="19A65BB5520AC4A5" modified="2013-12-11" version="1">MADTAAIQTFTEENPQFTLYSHDTGPNGFKVAELLSELGLTYKTVFLDFGNGPNGMKTPFFENLNPNGRIPAIVDHANGDFVLWESIAIILYILKKYDTEYKFWAKSIEDQALIEQWMLYQATGQGPYLGQAMWFTHYHPEKVQSAMTRYTDETRRVLGIVEKQLSREGSNGWIVLGRITAADISFLHWWCLAFRIGIEIETEFPVVHAWMEKLKAREGVAKGMTGAQFPKGEVEIKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7W1</accession>
    <name>U4L7W1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7W1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20586" checksum="DF695518694AC35C" modified="2013-12-11" version="1">MDSIIIATPTTLVLPTIYTNINPIATTSIIDTPIWPKKLPPDPEILYGTEVTPSSPPHTHIPPVAWFIFALITLVLFLAIYHIIKRRINTARQKRHDQTSVIDIEIEAGSYPQGPVFNAKSKQKLKDKILKKASAARVRDRAPTMVEGMEYNVTGAGNGKEPDVEGVRRPERAYTGSGGESSMRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7X0</accession>
    <name>U4L7X0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7X0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="11557" checksum="A667D4C6A4815ECA" modified="2013-12-11" version="1">MPPRLQPTFLHRLGSVFRRVCTNPNHPTWPIIFNISIQVAAASYIIWDSCRCNQKLWEDLRENLEDLEDLEDLEKRVHDMTIDMSKSILKILEDQGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8X0</accession>
    <name>U4L8X0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8X0"/>
    <dbReference type="OrthoDB" id="10320994at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="456" mass="53225" checksum="8F47D576CECFD648" modified="2013-12-11" version="1">MLHHSQLSPAEIQALLPGRREMAVVQRIREVRRKVVAECLERNDWTEKELKKLQDWFHIGRDRKLNTEELRKIKADFPLRSLLEKKINEFVWTPEEIAVLEKHYDTPPSNWSQEVIDEITAAMEPDKCFSNMKSKAYEMRRGVKLAGIWRKDELELLKTLDSVGLYVNRVSTALKEKIAEMFPGRTISAVQSKLSEIKGGGSCGKSGTRVWTNEQLDIIAEYRDRIEKTIERGQRITPLVDEICDRLPAISRLDIKRVLKASAQLDPSTTKEPITTESGFKTWRQEEFDTFMSHPTLFITSTPQEKKQAFPDRSLGAIRVKLCYWRKMITPEDWRKRVPEHLWDYREQTEMRRGKHNQWTDDDYKIYLAHPTRFYHTTTEQKCAAFPGKSASAVNRMISLWRHLERLKYMNSLGVTTKDDLPAQKIADMLIRDVEVEENIEEEAEQNGMPRMAYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L971</accession>
    <name>U4L971_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized lipoprotein ybbD acc. no. P40406</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935305">
        <property type="protein sequence ID" value="CCX06674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L971"/>
    <dbReference type="STRING" id="1076935.U4L971"/>
    <dbReference type="eggNOG" id="ENOG502QTNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMLCQSH"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="6">
        <location>
            <begin position="103"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="986" mass="109240" checksum="F91EB55B9538E80E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAP7</accession>
    <name>U4LAP7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAP7"/>
    <dbReference type="OrthoDB" id="10644586at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56103" checksum="F28F599CC1A5D456" modified="2013-12-11" version="1">MSLDAMPCELLLMIIQSLSDEAIRNHTHPYDIYAFRLVCKRFSKLAYSYLFRQFGLWPSSCRDIRPVQQFMRILNEEPTLAVYTESVAVVWPHTPQVQCLDPSIIGIGDSSGSGGGRGSGSGSVSMNGPLPARLDIRTSSEIALDTSIWEASLSLLPQPYPRLTTQLNGAYVPISTPLYNSLALTLLLPKFTNLKSLCIKPHPAILDPDLLFTATEYMVLNTRFPQLEYLEWDEGAKIEFCFHILLTAPKLRVFKGDFWRGSSELHEIASDLEPWETAYWTGLKSNVEEIHLTNSWMPAEYIPWLLSRTPRLTTFTYNYTHRSIPWDIASLNQGLRIVTNTLENLTILPDYENITPAFTGTHVLCPFVDFPRLKALATDLCWMIHPNYLFERQLDKILPRGLNYLELQNVFPSSSPEMLLRRVTRYVESLDLEQELLVRLWDTNQVGIAGIMYGDEQLLEYMQRLRRVVERREGRVRVERLPGGGTYFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBN7</accession>
    <name>U4LBN7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pre-mRNA-splicing factor srp1 acc. no. Q10193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBN7"/>
    <dbReference type="STRING" id="1076935.U4LBN7"/>
    <dbReference type="eggNOG" id="ENOG502S4TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLIRCDV"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX16210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="20620" checksum="E826B435129517B3" modified="2013-12-11" version="1">MSSRGGTTLYVTGFSHGTRARDLAYEFERFAFVEYESRRDADDAYYEMHGRRIGRDDYLKIEWARTPPSASWRFDGGRDPPPRRSRAGSPPRRGRSRSRGARDSPRRRSADRRDSRDRSRSPAARKDDDLDRPRRDRSVDRDRSRSPLPTNGDDREMRKETPPPHHEDDLDTADLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBP8</accession>
    <name>U4LBP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935365">
        <property type="protein sequence ID" value="CCX07727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBP8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17793" checksum="575E1A7B6196DCEE" modified="2013-12-11" version="1">MQDNLRARANCAFYADLPMVLADDRLSDRQTQSGPPSLTISGGINAEKAFEDIFDILLRNADPIIFDPYDGIRRLLRYVDVDGSFAVFQRIVDENEQELFHLGQIRFDLYFPAVRMKTDIILMKLLGQRRYLPAAGHQIKFLKDDIFVLLGGGQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCQ3</accession>
    <name>U4LCQ3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCQ3"/>
    <dbReference type="eggNOG" id="KOG3021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RECDIAM"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX29869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="300" mass="33031" checksum="4BC0F2A38329A86C" modified="2013-12-11" version="1">MQPDPALLRALSLSSADDISLHPHGGSNFTNTYSLSCPSGKYFVKTSTAPIAASMFLGEFTSLQNISRVAPELSSIPIAHGALENGGHFLITSFLDLPTGKGDAKQLAEGLWKMHNAELPDEVQGKGYGFGVPTCCGDTELDNTWASSWQEFLVERRMKPIARACKDLELEKMVDELCDKVIPKLLEGRKSKPALIHGDLWSGNASGGKVFDPASFYADAEFETGIMELFGGFGEVLGEYWKLVDEGADWVQGEKERRKDRVKCYSLWHTLNHVRIFGGSYRTGAVEAMAELKRKYNDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD78</accession>
    <name>U4LD78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Phosphatidylinositol glycan anchor biosynthesis class U protein acc. no. Q8CHJ0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935704">
        <property type="protein sequence ID" value="CCX12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD78"/>
    <dbReference type="STRING" id="1076935.U4LD78"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ALWHLWI"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="414" mass="45739" checksum="B00E4A4F98B7D234" modified="2013-12-11" version="1">MDRRSLLIIIFAVVLRLSLFTFFPSLPDLLTNRVELSTPVTSFKRLQEGLFLYTHGVSPYDGGIFHQAPLLLAFFTSLPSSSLLVHLIYTLCDVLSALSLITIASSKVPAITPLHTSSRAAALCPPWAAAAAFLLNPFTIATCLSRSTIVFSNTVILASIAKAVSGDAIPAMLALSMASYLSLYPVLILPAVVLLCYDMSGSKMPLSSYATQQGGVFFAAVAGLLGLSWMVTGGSWEFLKSTYGVHLLLPDLTPNVGLWWYFFIEMFDSFRNFFLCVFQLHLVIYLGGLCIRLRKQPLFVCTTMLGIMSIFKSYPSIGDTALYLSLLACYRHVFPVMRYTFFATSTLLYATLLGPAFYYLWIYAGSGNANFFYAITLVWCLAVTVIVADALFAVIRDEWETERPDMKGKDIVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDV7</accession>
    <name>U4LDV7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pentatricopeptide repeat-containing protein At5g46580, chloroplastic acc. no. Q9LS25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDV7"/>
    <dbReference type="STRING" id="1076935.U4LDV7"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="637" mass="71707" checksum="0A1F3D60E9EB30D9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE23</accession>
    <name>U4LE23_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE23"/>
    <dbReference type="STRING" id="1076935.U4LE23"/>
    <dbReference type="eggNOG" id="KOG2790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFVYFCD"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="7"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="405" mass="43517" checksum="B15F7E2401BACD8A" modified="2013-12-11" version="1">MPSRSDVYYFGAGPAALPQVVLERASASVLNHDNSGVGLIEQSHRSASSTQIVASACQHLETLLGVPKDGSYTTLWMQGGGTTQFSAVAYNLLGYWVQKSLDANNGDLEAVKAALANAKADYLVTGSWSKKAAEEAQRLLGDELVNVATNSKAATKKFGSIAPEETWNLTPKENNIFSYFCDNETVDGVEFPAFPASLEGTLVAADMSSNILSRRVDVSKYAIIFAGAQKNVGGAGVTLVVIRSDILKTQPTVDTLRKLGLPIPPIMCHYPTLTGASSLYNTLPIFEVFICREVMAGIIARGGLEAQEKVANEKAEELYSSLDQGGIYNVVPEKNVRSRMNICFRIEGGEDVEKAFLKGAEERGLTGLKGHRSVGGLRISNYNSIPQEAAAKLAGWIREFAASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE30</accession>
    <name>U4LE30_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935465">
        <property type="protein sequence ID" value="CCX09440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE30"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9113" checksum="93615AC41C1E6B51" modified="2013-12-11" version="1">MAKDDHDAVFVDSLMQEPSPILWALRALSNTSLYLEISDSTYEFPPPVSQPSRHQSVKFEIGPLFFSFCFSSSSAKIRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE85</accession>
    <name>U4LE85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE85"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="8777" checksum="5AF503F154B499A4" modified="2013-12-11" version="1">MHPRMALRCSRLNLGTAMKLNGNIKGPLYQHREGAQGGHIQIPRSLDAARSSEHLNAFGSNNISSKYISSLLHTCFTVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LET3</accession>
    <name>U4LET3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Ubiquitin-60S ribosomal protein L40 acc. no. P0CH08</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_08976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LET3"/>
    <dbReference type="STRING" id="1076935.U4LET3"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="168" mass="18504" checksum="E2F3A8B6F9E0BC4A" modified="2013-12-11" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKVYTTPKKIKHKRKKCTGPSWLSLSTTRSTVTERSSVSAASAPRRDVVPVSSWPPWPTVSTVDAATLPTSSSRTKLLVDGGGTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF08</accession>
    <name>U4LF08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein transport protein SEC7 acc. no. P11075</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <subcellularLocation>
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    <dbReference type="GO" id="GO:0030663">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032012">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
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        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
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    <dbReference type="InterPro" id="IPR032691">
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        <property type="entry name" value="Sec7/BIG1-like_C"/>
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        <property type="entry name" value="Sec7_C_sf"/>
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        <property type="entry name" value="Sec7_dom"/>
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    </dbReference>
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        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="829"/>
            <end position="1020"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="815"/>
        </location>
    </feature>
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        <location>
            <begin position="1236"/>
            <end position="1257"/>
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        <location>
            <begin position="1756"/>
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        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
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        <location>
            <begin position="722"/>
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        <location>
            <begin position="1236"/>
            <end position="1250"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX13531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2038" mass="226541" checksum="4B07E0C9D247CE7E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFB1</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935519">
        <property type="protein sequence ID" value="CCX10182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="26332" checksum="08CC02D1C728A3F8" modified="2013-12-11" version="1">MGGNLEPEGAGMTAMPVLEEAGNGIPLIVVLLDDVPVPMGSAGISAEFDGRIPLDTGMKDPEADGTTTDLETDPVALTRLLVDAPSAEETGSGLAVVMTGTLNVTSVGEAPQPVLQVATVVVMITVIVDGVKVTGTAVVMWVVAVEIPTQFISPGRRWICTYVLTFRAESLVLSLDNRGVDSLSRLGLRSVDGCYAHLRLGGHERHKTGEYKRFHDSVHATGSERKTSSLEKECHATLRVRKRMKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFV7</accession>
    <name>U4LFV7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LFV7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3790" checksum="B123CE9622E443D7" modified="2013-12-11" version="1">MVTAPQRSRDRSLALWHFFKSLRLKICLQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFY5</accession>
    <name>U4LFY5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Importin beta-like protein kap113 acc. no. O94545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX31029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFY5"/>
    <dbReference type="STRING" id="1076935.U4LFY5"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1046" mass="119670" checksum="30EA35B20AFB3AF9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG04</accession>
    <name>U4LG04_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG04"/>
    <dbReference type="OrthoDB" id="5430777at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16808" checksum="2FA3CCF9ADD044DD" modified="2013-12-11" version="1">MQQSLPSSVFETTTILKPQATGSDSMGSGNPNLGMDLLSLSVFAAGFLGLAIQITQILQTYVDSVRSTHEEAQKLLTDVAALAYVLEDIVKFLGSEDLKGRSFDKTSLLLVSIEVGRSCLERLFAKLTKIRDSFLIEKWNHGNCYADKVAFSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG59</accession>
    <name>U4LG59_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG59"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8772" checksum="A770BEF6DD450E54" modified="2013-12-11" version="1">MFSRVIGGNVSADGSPREVEMEIVMKSWKILDARKRYLTPSPPSSVPSRHLTTTTRIRKPKRDTTQDTRIRSLTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGP1</accession>
    <name>U4LGP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935531">
        <property type="protein sequence ID" value="CCX31078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGP1"/>
    <dbReference type="OMA" id="YITIYNT"/>
    <dbReference type="OrthoDB" id="10485764at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651357" evidence="1">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="30446" checksum="C8CEADA935DC14F3" modified="2013-12-11" version="1">MVSFKLLVAAVAAFSSVAAADGNVHRRMINKRYGYGNDTMDAPIGTGTAGVPYGTGLPVGTGVPAYTVEPTTYATSSTKCVTLTYTLGDGRAITKTITKTVEYETTAYETHAVPTAAPTPAEEQPVSIMPISESTAVPAQTEAPAQYEAPAVSAAPVANEAPVASAPSEKTTSTTTVTEYVTIPYGTTTVTVYPTAESAAPSGVSPAPQEDNHMVTVTDCSTSTTTLYVTSTLTPEAPAYTVQPAPAGPPYANYTTSKVVEGEHTYITTLYSSTAANPAGPTGTGVASASVGYMGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGR1</accession>
    <name>U4LGR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGR1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="69" mass="7968" checksum="5F3CFA8108E02B33" modified="2013-12-11" version="1">MKDANICFHLEAPFDRKVTSYIVSLGCCIFYDQRGCKGNPMFSALNRSHSRLGPEHDDRMRSFYCVKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH12</accession>
    <name>U4LH12_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized protein C4D7.11 acc. no. O14175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH12"/>
    <dbReference type="eggNOG" id="ENOG502S4TY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YLYFLDI"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="25464" checksum="E199984DB28644AA" modified="2013-12-11" version="1">MPNEIQEKRKDFLSHMLRSCDVIVYLNLTYLYFLDNSFLRLLLRGAMHFLFLTPKLIAVPFPPSQRMPILGLFGVTGLCILQHLWEPAPRAGELTHGYLHGGMIVDFIGQRPTSKFRLLFMDLFILFLQTCMLSLLIVKQELAPSSSSGPTGLTGLVGLAAGLRGDAQPRSDEEVEAEERGEVGVEEPTRSEEFLVTAGELQVARVDMVGVVQRQWGSTEATQGQTTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH72</accession>
    <name>U4LH72_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_10394</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH72"/>
    <dbReference type="STRING" id="1076935.U4LH72"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VPVKYCK"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="424"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX31263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="629" mass="69734" checksum="0E003076E3120050" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK35</accession>
    <name>U4LK35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C63.05 acc. no. Q9Y7T1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK35"/>
    <dbReference type="STRING" id="1076935.U4LK35"/>
    <dbReference type="eggNOG" id="KOG2830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYELCEA"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="349" mass="39327" checksum="8AEFB15EC791192B" modified="2013-12-11" version="1">MSEAPTLRQLLKSSSSLISSLSTHPSSNTPEYQSSVRDAISQLTTALDLVARASVFSLNESLDDVSTGDLPCLKITFSLADLYTKLSISTPFERKAALLRALQYYKDFITLLDAYDLVSATDRAAASNAGTGRPVSQLPTDPGQRRLAKIAQFKQEKELKGKIQQLEQGARLDEEEARELHIASLRLAVMQTTQQLEMITMELEMLKQAPPPEERERLREEQDERARQTKDDGYNERLDKIPNDIKGGALLNKDGKPLRPFTLLDKRQQLKDGVFRPGHSLPTMTIDEYLEEERRRGGIIEGGGEKSGEKPEMDLDDEEAVDKEMYKQREWDEFKEANPRETGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKB8</accession>
    <name>U4LKB8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Swi5-dependent recombination DNA repair protein 1 acc. no. Q9USV1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935722">
        <property type="protein sequence ID" value="CCX32022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKB8"/>
    <dbReference type="STRING" id="1076935.U4LKB8"/>
    <dbReference type="eggNOG" id="ENOG502SAMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTMAMML"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527">
        <property type="entry name" value="MATING-TYPE SWITCHING PROTEIN SWI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="311" mass="34380" checksum="997126C760C2778D" modified="2013-12-11" version="1">MSEPPATPVPPSKKRRLETAASTLKKPFRSPLISRTPGSTPKFTLPTPTSSVKSTLSSSFDCNESFDDNGKDNDEDYEPVRKFPATPAPRFAPKPKLPDTPDDSPTKPTTTVNSNRVATSVKNNFSLTHSTTRTPRQLFATPSFSNPELLAAQKKHTYLLMELKALKDSMETVTQALALEANPEKDTDLEASIKKWRLAGRYAADTLFGIAGDKVNMLGGPGNGGWRELVGGKKGWQDWEEENKEKGSDDEREDDRDEGIGGEDQEEQQGGIGKDEEWGMRLMLKSMGVPESMLGWDEDTATWKNIEEMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKE2</accession>
    <name>U4LKE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKE2"/>
    <dbReference type="STRING" id="1076935.U4LKE2"/>
    <dbReference type="OMA" id="RTENMET"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="362" mass="41624" checksum="DF54377114DF2661" modified="2013-12-11" version="1">MAPKPVLNVQIPTSDKMKFTEHDICIDIHGLGEIMQIMFRCHSDLIHSSFLSALDESGFDANNFDFSYAVNGEAGTESYKFEDEQAWKDFTIKVEEGKAWRNHRNGTIVIYGEEKKPEVADEENMENIGIKEQPEVTEQVEEQTEIQEQSEVTEEAEEQTEIDEQSGVSEEAEELTEIEEQSEVTEEAEESMENMEIQEQSEVSEQVEEQTEDMGIEEQSEVSEQAEEQTEIEEQSEVVEEAKEKMEIEEQPEITEEAEEQTEVAEEVEESMEIEEQPEITEEVEENMEIEEVSNPAEEQAEDIKTEEQSTVTKEAKERIENIGIEEQSEATEEAEERTENMETEEQSEVTEEADEKTEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKR0</accession>
    <name>U4LKR0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ABC1 family protein C15C4.02 acc. no. O60111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKR0"/>
    <dbReference type="STRING" id="1076935.U4LKR0"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCNPEDI"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="173"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="587" mass="66298" checksum="E13A9927AA2E1214" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL81</accession>
    <name>U4LL81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RCC1 repeat-containing protein C10F6.04 acc. no. O42645</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL81"/>
    <dbReference type="STRING" id="1076935.U4LL81"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWGNCRK"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="343" mass="36204" checksum="04FFD367FFB37BE3" modified="2013-12-11" version="1">MLFSFGSNGGGQLSLGHTEDTHIPHRCKIPPSFPSVPPKQIVAGGNHTLLLFPCGTLFVTGSNIYGQCGLRVSEGTTFTSFQLIPPPAETKWKLVSAGWDFSVLVAEDGGVYVCGMGSKGELGLGEGVTQTELRQVWQWSPESKVMDIASGMSHTIAILEDGSVYGWGAARKGQLGPGDEKVVNMPKKTKVDFKAAKAVCGREFSFVISGDGERHEVFGGDRFGIKSEMPGQGALKGWKSVGSCWGSVVVLMKDGSIKAWGRNDKGQLLPEGLKDVRSLAIGSEHGVAVAGDKLVAWGWGEHGNCGNEGGGDVKGEVHEVQVDGEGELVMVGAGCATSWVWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLB6</accession>
    <name>U4LLB6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_08257</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LLB6"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
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    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="Condensation_dom"/>
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        <property type="entry name" value="FAR_NAD-bd"/>
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        <property type="entry name" value="Lys2"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="PKS_PP-bd"/>
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        <property type="entry name" value="Thioester_reductase-like_dom"/>
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        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1366"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="20">
        <location>
            <begin position="872"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX30155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1420" mass="155650" checksum="6BE0217D2CF08E4D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLK1</accession>
    <name>U4LLK1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein SNA4 acc. no. Q07549</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLK1"/>
    <dbReference type="STRING" id="1076935.U4LLK1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="18147" checksum="46F3BEC9A27FE42D" modified="2013-12-11" version="1">MCSPDILLACIAIIFPPVAVWVKSGICSADSIINIALCMLGFLPGLLHAWYIISIHPSDEPERPHDAESGRDPRVRYNRTQSQQPQRQGIHYGQHHPPPADNYGSFGVTPRDQPYGHPQQQPYYGPPRGQNGGSSRAPEQGTPGEPPSYADVLKDQLKDHKIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLL7</accession>
    <name>U4LLL7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLL7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="37" mass="4391" checksum="14C4BD3449232239" modified="2013-12-11" version="1">MYPVYEMIDVTKKRYFAFILNTGVVGPDKAGRVWRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM20</accession>
    <name>U4LM20_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <end position="1062"/>
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                <person name="Gabaldon T."/>
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        </source>
    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <begin position="30"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX15408.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="73" mass="8701" checksum="C30ADFAD1E5E9E5B" modified="2013-12-11" version="1">MWGVLVVLMFCNLRREMLLPAAVLDVVSARWMGCRRWSWHGWPATSGCFTTWDGWRISSYHILHFRFAFPDLR</sequence>
</entry>
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            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN35"/>
    <dbReference type="STRING" id="1076935.U4LN35"/>
    <dbReference type="eggNOG" id="KOG2212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVNFVWQ"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="12">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="793" mass="85647" checksum="CCEC629D960C0FEC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP64</accession>
    <name>U4LP64_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_01038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP64"/>
    <dbReference type="STRING" id="1076935.U4LP64"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GGCKWQH"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="505" mass="55883" checksum="B9318585FA12FFA1" modified="2013-12-11" version="1">MEAVGPAGPDNQQRIEKRKFPNRPGGGQKRMRREKKKPVKEGGAEEVLEIDIKNLLASQPETPETASVQLPAPFTELELEVIQLSSIGDGLAVHEGRAYVVPFSLPGDRVAVKVIRHADTHTVVDFLKVVRPSPDRDDSLIGCKYFATCSGCQFQMLAYEKQLEHKKQVIVNAYKHFGDFPEGLLPTVGETIGSPLKYNYRTKLTPHFDGPRRGGFNPDMPVPEIGFNIKGQRKVLDIEDCPIGVDSVRSGITDQRKYVHENLTKYKRGATILLRENTVRTVDEQDPTKFTEEKTFITDSNAVSTEYIGNFKFTSPAGAFFQNNNSILPTFTAYIRDNLSLPVSADNSASEPPKYLVDAYCGSGLFTVTCGSTVQKAIGVDISADSIAYASKNAEANGITNASFIAGNAEKIFADIDFPGSETSCIIDPPRKGCDQLFLDQLLEFKPKRIVYVSCNVHTQARDMEYILKAEKGKGYRVDSIRGFDFFPQTHHVESVAVLTWVGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP72</accession>
    <name>U4LP72_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Probable mitochondrial 2-oxodicarboxylate carrier acc. no. Q9P3T7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_10020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP72"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="33194" checksum="ABF319A387E64993" modified="2013-12-11" version="1">MAAAADKKNMPIPFKVTFVGGAIAGISEILTMYPLDVVKTRIQLQDNNAKGADRYNNMFDCFKKIVKQEGFSRLYRGISAPILMEAPKRATKFAANDEWGKFYRKAFGVDKQTQALSVLTGATAGATESFVVVPFELVKIRLQDKASAGKYNGMIDVVKKIVAQEGPLAMYNGLESTMWRHITWNAGYFGCIHQVKSMLPKQETKKGLMLNDLIAGSVGGAVGTILNTPFDVVKSRIQNTTRVPGVVPKYNWTLPSVALVAKEEGFAALYKGFVPKVLRLGPGGGILLVVFTTVVDYWKSMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPL9</accession>
    <name>U4LPL9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPL9"/>
    <dbReference type="eggNOG" id="ENOG502T2F6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="217" mass="24089" checksum="9B127A5775372B8C" modified="2013-12-11" version="1">MDTLSLSTGAAGLLSLAIEVTRILHNYISGVRSAPQDASELNTEDSALCHVLVTLVEDLRNNDINTKGKAFDDQSILRAVITECQKLIAAVYKKISKLKSTDKTAVLIARITWPFQKEEYQEAVRTLHRYVQTLQVLLIASNGSLLSESFTTVIAAMEEQHKRAMGSIEMMNENLIAVPEGMFQISEKLENAITLVSDLASSSAEIRNISKEWQNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPY9</accession>
    <name>U4LPY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein SERAC1 acc. no. Q5SNQ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936514">
        <property type="protein sequence ID" value="CCX16768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPY9"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX16768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27987" checksum="B8D1A60FCE3A4C31" modified="2013-12-11" version="1">MLRDYLDTLNIGNRFVIRDYLDTLNIDNRCMKGNSQVLSLAMYGSWQVASVSFEYHEPDIFRGCKPDQNIYLQFPKRRIEGRAVPVNVTVDCDFYGMTPFYESPEDMIKYDIIAVTGLSAHAFGSWKSPDQAHVMWLRDFLKIDLADSRVLTWGYHSDIKNDQSTTSIAAISRDFLQDIKFARRKSASDRPLILIGHSLGGLVLQQALADAGKETDEENGTLLRSCIGILFFGVPNLGLNPQASRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ14</accession>
    <name>U4LQ14_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ14"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="20610" checksum="77E3F8762F1A5A23" modified="2013-12-11" version="1">MSPASEYSVPGSIYRYNRQKWLENHLLSIPLEDQQILHRSVHADHGWDPKPLQPDPTNRVNQGPERRASQLTHHKRSHSIPIEASDNRYHLVFPDQRRASESHSTPVIYENPNANLKVLRSSLHRPKPIQRNPVVREFDAPPPQSPLWGSDISDTIIEKEDFEENRYFIGALVFWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ50</accession>
    <name>U4LQ50_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ50"/>
    <dbReference type="STRING" id="1076935.U4LQ50"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX17396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="393" mass="43910" checksum="B96B03D97DF53CDF" modified="2013-12-11" version="1">MRRFFKSFTSSSDSGPVQTISGNNASDPMREKDVVNVKHTSKNFQFAFKKDGIANNEVTLGEVKRLVAEKTGVKAGKVKITCNGRRLEEDDKALQQLGVEHNAWLVAVTPTAKASAQEGVAGGIAAEIAKKNLSPEQEKIQKMDTVLLRIEKELVPGVIDFITEKQMVRIRGVEKKWEDAFAILDEYLLQEQLSGLDGVYPGKTEKLARQKKRQATAFTQGHQTAMDFVRKLKKAVTPAEVEEIAKDWDLGRRKAVMKEAVKVVIDDSTVEEGLKKSKWGRRVEREQREALVADGIEGDDLREMVENRWEKEVDRGLFNALGGTKDDKEIDGALKKLLKDPAGEQMLKEAIMKVLENGEIEKAVKVARRGEEIRGQIEKYRVKLGNPGNQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ94</accession>
    <name>U4LQ94_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ94"/>
    <dbReference type="STRING" id="1076935.U4LQ94"/>
    <dbReference type="eggNOG" id="ENOG502S57E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2142213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651668" evidence="1">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21305" checksum="8E926354635674B3" modified="2013-12-11" version="1">MLTKQILLSAIILGSCAQAAQIKPLLFDEYTSNMDDHFLSRDIRDNQQPAKVIKYNEWTESIPFACYVYGKAMDCPAKNIQVWETTYEDCQQPWTFCRCKDSTVTQHEMVEEFGRIPVALRENVVNVMAGPAGALASSAHVGPGTDITFQGPKASMSPLLVMRRYTLSKLHEKEVILRLFPERSAPCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQC8</accession>
    <name>U4LQC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Probable prefoldin subunit 5 acc. no. O94307</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQC8"/>
    <dbReference type="STRING" id="1076935.U4LQC8"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="16521" checksum="37AE1E1BF384B1D9" modified="2013-12-11" version="1">MAAPQQQQIDLNSLTIDNLAAVKKQLDDEIEHLMGASTKLKKAQDRFREYINAVKAGIKPETSDKPLLIPLTTSLFVPAKLSDPEHVLVDVGTGYFVEKTAPEAVKFYTAKIKTIETNMADIQKVMTQKLQNVRVVESVIVQKQTQGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQJ2</accession>
    <name>U4LQJ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pentafunctional AROM polypeptide acc. no. A1CP85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LQJ2"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENDSFWA"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046565">
        <property type="term" value="F:3-dehydroshikimate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02238">
        <property type="entry name" value="DSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043700">
        <property type="entry name" value="DSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14696">
        <property type="entry name" value="Glyoxalase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01028">
        <property type="entry name" value="DEHYDROQUINASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="301"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143703" checksum="E564275386A43875" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQL1</accession>
    <name>U4LQL1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQL1"/>
    <dbReference type="OMA" id="CKWKIAM"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="11650" checksum="323C8529515BCD13" modified="2013-12-11" version="1">MRSKWGLCKWKIAMGRGGMDMGGRWKRKEEEEEEEEEKKKEKKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKVHRRLMQERIGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQZ1</accession>
    <name>U4LQZ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to NADH-ubiquinone oxidoreductase 9.5 kDa subunit acc. no. P42117</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQZ1"/>
    <dbReference type="STRING" id="1076935.U4LQZ1"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="8936" checksum="BCDE69C10F625AD2" modified="2013-12-11" version="1">MPVAAAPSLVSQPMRYCRWAARNYPARFYSVVLGAFALAVPVAIPVRRALGYKDHSPVPTTWPIPNRKREAVPTEFDDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRK9</accession>
    <name>U4LRK9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRK9"/>
    <dbReference type="STRING" id="1076935.U4LRK9"/>
    <dbReference type="eggNOG" id="ENOG502SQJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HGSFTDY"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="42849" checksum="C37AF2F70EF5A78D" modified="2013-12-11" version="1">MYLITLIQAAAIAFHILPVFADLAKIPIIRPTGHYKVGALDIKLEDKSRHDYFSPSESRKIVVTFHYPTDKTTAFLRPYIPFTIQPIVEADYTIPPGELSRLVSNSYQYAIPAKLPSPAAIIFSPGFRSSRYLYTSLCEDLASHGFVVISIDHPYDALAVEYPGTNKTVLMHPSAGNATLDTIHPFHTQRAEDMTFLAGVLKDWLRRLEVHTESVNALKIGAFGHSLGGATSAGAMQRTKLIQAGLNMDGFFVNGTTTDDAIKNVERPFVIMGAGKHNSTSEKTWREWKKYQSWWYKELNLVDSGHLSYGDFGAFVEQLGLRDKMDKQFLEGYLGGLNGERAVKVQREYIRDFFDWQLRGGKGEFFKQAQKDFPEMVFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRM1</accession>
    <name>U4LRM1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Putative mannose 6-phosphate receptor-like protein C530.09c acc. no. O59745</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_03033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936394">
        <property type="protein sequence ID" value="CCX34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRM1"/>
    <dbReference type="STRING" id="1076935.U4LRM1"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTKSTIM"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651604" evidence="10">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="33057" checksum="5D2613A89E07B18D" modified="2013-12-11" version="1">MRISTALSLFLFCFSSALADSASGDSKKLYKPKDAECTITSPYSENFFDLNKLKRTPGAAPPQMDWQVKGLDYGANFSINICAPVLADTSKVEGIDEAGRANVGAYYEKNGTIYSIGSVSTTPQFRGRKLILAYENGSPCPNAPELRKAALMSLMCDHEQFHKPSIAFVGQFNDCAYFFEVRTAAACPTLNQAQALGPGAVFGAIMGVFVLVYLIGGIFYQRTVMHARGWRQIPHYHAWAATLNFFWVRLFVAPILFILRILSFITCGRLGSSGRRSTSIRRSSSSIEQAGWKRHDEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRQ8</accession>
    <name>U4LRQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRQ8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="10121" checksum="EA31906ED2A6AE42" modified="2013-12-11" version="1">MPRWKWSVAHKRHLPKAVSRTVQVAQGSSKIKDCQGLSETDKGKAVYLRDPSCAGCRQSGTKFRRMKRPGARGLQDTRAPPLSALCAKPAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRW0</accession>
    <name>U4LRW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat and SOCS box protein 8 acc. no. Q4R544</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRW0"/>
    <dbReference type="STRING" id="1076935.U4LRW0"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="194" mass="21444" checksum="A8856D9E3EE6664B" modified="2013-12-11" version="1">MGAKKSAEEEDENKNPAALAIWRNQLSLFEKFLSHGLPVETRVVKLSYPRTDAVTFLHPSFSSLKSRKLGDTTITKMPLDRGADVNNRGNCSASMLHYIIDPDPGFEHALPSNLWLTLFLEHGAVVDERDIIGQTPLHIAAFSNSADAIEVLLKYGADINARSHNCDHTALKMAIVAEMPDSERVLREHGATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTU4</accession>
    <name>U4LTU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to mRNA 3&amp;apos acc. no. Q4IPA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33120.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTU4"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33120.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="121" mass="13767" checksum="CF2449D0F1260EE0" modified="2014-03-19" version="2">MDPIPVDDTLSVDSDLEATSEDIEYDEYDYENTQDDDDEDASSGNDVSVASLASSIHEYVDKHGRTYHTYFGMEKYPVPADELEQDRCVYSYLPLLDLSDQATKSIVEIYDFRNLCVNDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTW0</accession>
    <name>U4LTW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Probable tRNA-splicing endonuclease subunit sen-15 acc. no. Q7RY78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_14200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTW0"/>
    <dbReference type="STRING" id="1076935.U4LTW0"/>
    <dbReference type="eggNOG" id="ENOG502SC4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYYFVYK"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15676" checksum="74B0899AA1B948A8" modified="2013-12-11" version="1">MSYSDLAVSSHPHLIRIVENHLLNHADWRSVTQHAFTPRPLLSGIPPEPVYVDPDVDPSKPPTEAALEQVEWLLPVDLREKWSPRKMAEVFDSLPEGVWGENAKGEKRTKRMLLAVVAEDSTVSYYFVHDGIVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUA5</accession>
    <name>U4LUA5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUA5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="20956" checksum="2CF6E706E9F5D464" modified="2013-12-11" version="1">MRTITDPLSDHASAGLAEINGSSTGAKIAQHRKAHDQSTTTRGEIMYKTPLCLLPFSTSSNKQSHLLFQQQQTNQPTQPTQSTCSSPPLPPSSPSLPPLSVPPSEPAPSGARTPTPSSLTTPTALSSGSATPGDPSRLTALRDSSSPPSTTGVTTRRTPSATRTRYWSSDRLSITLWSLGALGGLEYRKHIGGYYNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUM8</accession>
    <name>U4LUM8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUM8"/>
    <dbReference type="STRING" id="1076935.U4LUM8"/>
    <dbReference type="eggNOG" id="ENOG502S5JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWMSAGG"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="80"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="508" mass="53937" checksum="7159281BB63CABD7" modified="2013-12-11" version="1">MVHPQYVQQQMPQQQQQQQQQQQPQFVHQQPMQYHPQQQQPPQQFQQQQQPPPQQQQQQAMNSMPPPTAPASKPTDPTDLADALTSAGIDLKEEEARLAQFSNTGFQHGYNVDPYTGQPLSAEDAMRIEHRRRAALKANHLNDPFLHPNVLAGILANKTRTENCNQFVFDASGAGHDIVTLLSLAASERLKTLLTRSTALAKVRRRPQTTITGEWADKIAGATTEGGTNAASSSPKNNLKSEKKTSFALSFAESLLTRPPTGSFSATGLGSPPPPGSLATSTATLGGPSATLGAGAPEQPTATLQNATARALRQLKQTEYERDQARQRKRAKREASLLASGGAPSTPGTPSAPGADTAPGTPTMEPKVSLKESRKQQASKIEEAASHRAANATANMMMGGFGGAFGLGGKKKKKTYSWMNAGGGPGGGMVGARAGPVLGGPGLGGIMEGQGQAQGDLGGLNWTGQRLGVWREDGERGKGIQIRDWVGALEGDGRTGGKSVVRAYLRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV10</accession>
    <name>U4LV10_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936379">
        <property type="protein sequence ID" value="CCX34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV10"/>
    <dbReference type="STRING" id="1076935.U4LV10"/>
    <dbReference type="eggNOG" id="ENOG502S2FQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SGIAVCY"/>
    <dbReference type="OrthoDB" id="2596908at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651938" evidence="2">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="328" mass="35496" checksum="81F1476E99524351" modified="2013-12-11" version="1">MRRSNILRALLGVAALCTGVSAIENAGDAAGAIHFPGPSILSTPATPAIPAPEAPESDPLIALIKRSSDLVSDLSSLFKRGGIRNEADTKNLDLESWSRDTVKLCADKLNKTVIPNNPSGVAGCWNLPLLVDSTGIFAADLRIFRIADPTGDWKDVEVSSYNISVQYDGSAAIQPRNMTVMERRASLEGMKGSNLTKLVDTQFIGNLDKSLISGQLNDSELKVMVTPTISIYAKTKTGKAVNTTVSIESSKFLNGVFAETKDLNQKEKDEIKKEPFELPGTKIEIVPAGLYFYAAYTFVGLTIFGFGTLERAKFRDQYRSRLAGQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVH7</accession>
    <name>U4LVH7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVH7"/>
    <dbReference type="STRING" id="1076935.U4LVH7"/>
    <dbReference type="eggNOG" id="ENOG502S1ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YNSHEQK"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
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            <begin position="48"/>
            <end position="74"/>
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    <sequence length="564" mass="63273" checksum="3B5CCD229B776F55" modified="2013-12-11" version="1"> </sequence>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="343" mass="39393" checksum="0C6718C5862C5B27" modified="2013-12-11" version="1">MEPELSLAAVKGKRVADLMDDEHESQEEQHRPLKQQKSGDLRGTAEAATAAIAAAEIGFAQQAQHIPALTVDLRSELTATSDSDSQNVLNKLFEEILKYLQIQQLVAEYFCAIKRGVANLPYQNWTIHYLAANGMHEKMKTEWFSIWDTIRQSHVQKRFQELEQCIKRRAGRVEKLGELLSLAHGAGIGTAAVVSATLQQKITPEKFRFNWEKQVLYISKIFDNMQDLLRAYWEMTDGDRQSYNPVYAWHQFVKFKAQGSRDFLRDGVKEGLTRFFTNASRWHPSQSYAFLQYGKGFINDIRTTLESFGAWEDLNKFIQEEEERLRITEADALWGRPVVPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWM5</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <begin position="239"/>
            <end position="332"/>
        </location>
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            <begin position="420"/>
            <end position="606"/>
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    </feature>
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        <location>
            <begin position="676"/>
            <end position="799"/>
        </location>
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            <end position="267"/>
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        <source>
            <dbReference type="EMBL" id="CCX33898.1"/>
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        <source>
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    <sequence length="861" mass="95904" checksum="B4CA3EFE76CEA4AE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWR0</accession>
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        <submittedName>
            <fullName evidence="4">Similar to Actin-related protein 4 acc. no. Q5AW89</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_02481</name>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWR0"/>
    <dbReference type="STRING" id="1076935.U4LWR0"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000184">
        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ACTINS_2"/>
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        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000487"/>
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        <source>
            <dbReference type="EMBL" id="CCX34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="435" mass="47181" checksum="2F69973F17BF7002" modified="2013-12-11" version="1">MSGPSTLPTSQAPSALEYGGDEISALVLDPGQCWTRAGFAGEDTPKTVIPSHYGYVNGGDEGKKYYFGDNDVHALRPGMEIANPMADGIVADWDVAPQLWKYALTSRLTTELSEHPLLITEPVWNTPKNREKTAEIAFEDFDVPAFYLAKSAVCAGFASGKPTALVIDIGASNISVTPIHDGIVLKKGSVRTPLGGDFISNQIRSHFAANGIPLSAHYQVQSKMPVEVGKPAEATLRQFKSGEEPTESWKAFQEERVLTEFKECTAQVWAGPGPVPAQGTEGIGGRTFEFPDGYNLVFGAERFRITEGIFAPRQMLIHGEIPHPDPETTQGFGGMVFSAVRDVDIEIKPHILNNTVVTGSGSLLYGLNDRINNEMANVFPGPRVRLTASGNSTERSYASWLGGSILASLGSFHQLWVSKKEYEEHGPGIVEKRCK</sequence>
</entry>
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    <accession>U4LXB1</accession>
    <name>U4LXB1_PYROM</name>
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        <submittedName>
            <fullName evidence="5">Similar to R3H domain-containing protein 2 acc. no. Q80TM6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03519</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LXB1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFCRVPP"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H_dom"/>
    </dbReference>
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        <property type="entry name" value="R3H_dom_sf"/>
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        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
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        <property type="entry name" value="SUZ"/>
    </dbReference>
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        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
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            <end position="201"/>
        </location>
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        <location>
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            <end position="294"/>
        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
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        <location>
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            <end position="82"/>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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            <end position="446"/>
        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="644" mass="70718" checksum="AB52C0E841DB3C00" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXZ1</accession>
    <name>U4LXZ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to SWM histone demethylase complex subunit phf1 acc. no. P87233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04173</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LXZ1"/>
    <dbReference type="eggNOG" id="KOG4323">
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    </dbReference>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
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            <end position="193"/>
        </location>
    </feature>
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            <end position="342"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="113"/>
        </location>
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            <end position="145"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <end position="178"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="484" mass="53764" checksum="8DD455D7FFA22FFC" modified="2013-12-11" version="1">MTEDFEQNMAANDPELLIRQQLAPQVSMAPQDLPPELALQQWHHQQQVPQQQQIMPQQQPQQYQQITSPSQQLFQQQLQAQQAVMAPPPPPQQVADIAPMAHIDTTHTPTPTISEAPTPAPKTSRSARPKPATKPPARKPGRRKSSVVIKDDSDGSMSEEFTMEGIKTKSGRKVHRPTHFNPAQKTPSRRRGPYRRNYDARICKLCQRGHSPQSNMIVFCDGCNTPYHQLCHDPPIDDLVIQVESAEWFCAGCAKSREQRPLTMGLTGQSLSDEEKRMYLASLPMSSLVELVFFAEKQHPDLPIYDPQTKEIVAAQKAARAKDTTPGGTEEVATEEGDGQGPNWEEMIVRAITAQDIGKGVQPKWIFEWISQNFPALEGRDVRAEAQSTLQATLRKERLLREGHAYRLNPAWVGSPTFAKPQLEPGHLPPGGGIKLPLETEEEGAASMLCDDDSIGFSHLWGDAIQLSGGVEDSLMMDGIMATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU95</accession>
    <name>U4KU95_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_01281</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU95"/>
    <dbReference type="STRING" id="1076935.U4KU95"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="189"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX04261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="520" mass="56006" checksum="A4B387DDB1D0382D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWE2</accession>
    <name>U4KWE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein YJL213W acc. no. P40896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWE2"/>
    <dbReference type="STRING" id="1076935.U4KWE2"/>
    <dbReference type="eggNOG" id="ENOG502R71Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPGPRCL"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="98"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="488" mass="53868" checksum="DC606E7DC959FB3F" modified="2013-12-11" version="1">MSPVPIHVEGSASDKKPVHYPKFDNKLKPKNYTIQGTHPDSKVLFLDVNIIDGSGEEPYRGDVLLEGEKITKVGKVPNADELKTNPRVRIIQGRGRTLMSGLGDAHTHFTWNGGDLGGLGDLGIEEHTLLTMRSAQCYIDSGYTMCFGAASAKDRLDVVIRDAINAGDIPGPRYLANGKEMARRGGDLVASISAFADGPDEMRKVINEHIDIGVDQIKLSMSGEEITETRSAQDCYFTDEETAACVEEAHSKGIRLCSHARARDSVAQCVKHGVDVIYHASYIDNETMDLLEERKDKHVVAPGLNWLYATIYEAEAFGYTQEKAEKVGYKKELDIAIKGLKEMHKRGIAVLPGGDYGFAWTPHGTYARDLEHFVKLLDFTPMEAILSATRGVANLFMRGDELGQIKEGYFADVILVDGNPLEDITVLQDHDKLNVIVINGRVHKCGYREFVPPPVAGTTEGKQSVMVPGFPEIKRVMQKPLKADRWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX12</accession>
    <name>U4KX12_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX12"/>
    <dbReference type="STRING" id="1076935.U4KX12"/>
    <dbReference type="eggNOG" id="ENOG502S0WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EICHAHP"/>
    <dbReference type="OrthoDB" id="9987011at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="35649" checksum="9D24E980C427E086" modified="2013-12-11" version="1">MEFFISRHGPNRTTATLNRSFLSEAGSRLFVLPRLHPELIPVALALAIPTLILFAYFVYQDYLAFLALGPGGTPSTPLGYLRICLLKVFALRNTLKCSPIPDHLRNTGFLRDPLPARRSARPVVVGIAPHRQKSQNPSATIYETLSNRIKQLAVDFPEKLEIKVSAFEKHCAALFSRASGLEGTKGRGEVCHAHDSDGSMHMTLHPEDIKRVVEAGWGERHPLARGGFFCRFVPQEFIMVYAPRTEEEVEIVMQIIYAGIGWISGEEFPPVPRSCCGANVSISVNTGRNGTSASVNVNKGPVAAASFVAPGPPHPEVDERVQATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXM2</accession>
    <name>U4KXM2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXM2"/>
    <dbReference type="OrthoDB" id="10509792at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="447" mass="50694" checksum="368EF29169D6607C" modified="2013-12-11" version="1">MSERPVSSRELRRHISRSNNRQEDSEWVALGHEESDSIIFGSHGSSSLLAGPLHFRHVGNQPPLRRVHGHRNLSALVPRPPTPIPRDVLPLRPRAGTVPATRISSSSSGLQIRGSASPRAQGHAPRRERNIFAPSSNGSSERLATLSVENPRSPENFDGILRPASDNRAVSGSPVAPAVNTAPSPGNYDWLELNREPARPLCLLGMSVPVLPPQRVMSTRVPSPQYEYDPRKFQVYLEQEDIERILEWLDSVRYSPPPTYNCPDLLSPPPGQEFRRSASHRGEQYREQRLPQHADDIHHSAVVITPPTSVETRMGMQRQQMQSYVPDNPAAYTRGDHHHDSFQRRAEYERQRVERERQLQHFEWLDRQARLRREFDERARIAEEARIRATQPEVQHLLSGDVENHIAEAINDAMSEGEAEDDGAVGVPGRPFVEQNEGLFRRFFRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYW6</accession>
    <name>U4KYW6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Uncharacterized mitochondrial carrier C227.03c acc. no. Q9UTD6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_03811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYW6"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="71"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="193"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX04829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="320" mass="35142" checksum="66CA79BBB8A38482" modified="2013-12-11" version="1">MKGLSSSASSLSDIRSFLQAAPPRFPSPESVSSQRTSTTHPEAHPQSPFAELPKSFAKYRIGATQHGLLADKATPRASIQPSVVEYCDRKQLPERFWRMKISAREMEIIESGGATILLSVHGGSRYPSAFHYTNTLDAFRKMYNDEGLRSFYSSLTPALLGLTHIGVPFPVYEYLKGKFTGVALGKQGKDGKTNFGGILLAGCLSKICASSATYPHEFLRMRVQTQRILNDATSAAAAGSGSATSTQVRYQGVMNSVRTIYREEGCRAFYSGMGTNMVRAVPSSAMTLLTYELVNGFITRLREESIVHYGHDREEGERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ02</accession>
    <name>U4KZ02_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ02"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="178" mass="19682" checksum="A13F5F21EEE533FB" modified="2013-12-11" version="1">MDFYMKNRWEMHTIHPCNVIYNHTSLPDMEQSMNTAFSVSPQNSVSIVEDYTLLLPAPAKINTDYLASTFGMHSSCRLASKACGLYTTGQNATFNCSTTDGWPGPTKFAMDLMSSEQYLPDMWSNATDSKGKETIQKPFNFGFAKRFSLASGDLINSGEVVTDFHSGLSAVILCELAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZD0</accession>
    <name>U4KZD0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C557.02c acc. no. Q9USS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZD0"/>
    <dbReference type="OMA" id="YNAKVYR"/>
    <dbReference type="OrthoDB" id="5363415at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="220" mass="25403" checksum="327F68C38A018BAB" modified="2013-12-11" version="1">MSDPQADLFRVLAQLNPAITQQLQQFQQPQPQFHPPDAPPPQSLQFPLQPPPQQQPLDPRLTAKPPPPARPDPRTIVTLPAANRYVSRYIASSAETLTALRALKRWQHAKESSWYAARQALIKRHKERSESDAKLASLLQSLTQAPTVKPPDSEKELRDYDRSVYEKQRLMQKEIFSEMNRLQIPLFYQTVNYGVDETTLNIWRRRLMDLLEDLCDDEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZD9</accession>
    <name>U4KZD9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZD9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6291" checksum="5E74DE701893D9B9" modified="2013-12-11" version="1">MLSSSLSTSCEAYAESDTVESVITFGITVKSRVPVRTLPQLFLGHHETMNHSLVRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZN6</accession>
    <name>U4KZN6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Altered inheritance of mitochondria protein 9, mitochondrial acc. no. C4QYL7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZN6"/>
    <dbReference type="STRING" id="1076935.U4KZN6"/>
    <dbReference type="eggNOG" id="ENOG502S3GD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYCETSS"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF51">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="232" mass="25734" checksum="77AAA9DC43DBE4D5" modified="2013-12-11" version="1">MSMGVMESETGSLNDAANTIVTHSSPVSSIAASRTSAESDDTFSPVASVLSTINSKLVESLDIRARREQSQGLRGPGVDQELRCTIEQPPNSGSYNLVHTLKFSDGAKWILRIPCLGANGSFMPERSRMLRSEAMTMSFIRRNTSMPVPEIYDYCETSSNKIEVLYLLMEFAEGFSVFEKWFDDTGPTPKEERQMRILDTTAAAMSQLRKFEFDKIGSLQFEPGNMDATGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZP2</accession>
    <name>U4KZP2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_07278</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="HF935363">
        <property type="protein sequence ID" value="CCX07689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZP2"/>
    <dbReference type="STRING" id="1076935.U4KZP2"/>
    <dbReference type="eggNOG" id="KOG2589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="112"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="501"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX07689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="652" mass="73474" checksum="17E9547B7560B52F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZQ7</accession>
    <name>U4KZQ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935343">
        <property type="protein sequence ID" value="CCX07230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZQ7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="203" mass="21474" checksum="0C686CF203546FAD" modified="2013-12-11" version="1">MEKMKQFLKRKHSKGKDPEQTAPQEENLTQRQHEWMLPAKPGQKCPRHNDIIDFGGYYGITGATAKALGLLRDSATGSSANVKSASRSSTSASSASMTPLSATSKTTPAPAAPNASNTQHLMSVTIPPRISSITTGKMPSRAGPSTPAIAKALPPSSVNDNKASTETKSVKPVKPVKPPVLGNEYIRQMDAKLQAQNSAGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L016</accession>
    <name>U4L016_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SAM50-like protein SpAC17C9.06 acc. no. Q10478</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L016"/>
    <dbReference type="STRING" id="1076935.U4L016"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SGIWRQI"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="166"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="507" mass="54425" checksum="8C83D1C5E4B5C84C" modified="2013-12-11" version="1">MASTLRNDEDVFDRLASAIDPVVTSEREKAVQERVRAQYEKAQKRLSELIDSNSTLPVTISDIRIHGIKKTREGFLQSVFKEALSAEKQADYTLKTALEALQKTTDKLHRFGIFHPTINMYLDRGDAPGVISADLSVSERGRLMLNTGTEIGNAEGGGYLNGTIRNVFGGAETLYASASSATSTADIGSRARSAYEVTFATPLFANPDTVADIGAFSSTRSNHHVSSHEEASKGVKAGLKFLSKCGNHELNYNGVWRQVTNLSADASTSVRADAGDSVKSSITHTFTRDYRDSTLLPTSGYLLKNSTEIAGFGPLGGDVAFVKNEAEVQHAIQLNHGMSFTAGLRAGVMCPLPLGFGENQQAPKASRINDRFFLGGATDIRGFRENGLGPRDGNDSVGGDLYVAGGASMFIPLPRLGAQSPFRFQAFVNGGRLVGMQSTGEKGDVKTSLLDAVREIGIGYPSMAAGVGLVYAHPVARFELNFALPVVKREEEKGRKGLQFGVGINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1B2</accession>
    <name>U4L1B2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Adenosine deaminase-like protein A acc. no. Q4V831</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935403">
        <property type="protein sequence ID" value="CCX08247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1B2"/>
    <dbReference type="STRING" id="1076935.U4L1B2"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RPQFKPY"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX08247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="351" mass="39802" checksum="5A74D581D79D14C4" modified="2013-12-11" version="1">MKEFCKRLPKIELHAHLSGSIRRDTLHHIWQQKKSESPELTLEDPLLVIPEEGVKDINAFFPLFSKYIYALINTVSTVEFSTRAVLNDFCADGVVYLELRTTPRDFPETGLTKQKYVETVLNTISEFNASNGEMKARLILSIDRRDDVEKAWETVELAKRYKKEGVSGVDLCGDPLKGDPSIFAPHFDAAKSAGLGLTIHFAELPQSSSDSELFTLLSYNPDRLGHVIHCSEEVKKKLVEKKVALELCISCNVQIKMNPAVTTHKEHHFGEWWREGNCTVALSTDDVGVFYSELSNEYWIVHEHFGLGKRQLWELAKGVVDATFAEKEEKERLKGVMDKFGAAEGLWQIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1X8</accession>
    <name>U4L1X8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1X8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8276" checksum="2B778764EC2FAD70" modified="2013-12-11" version="1">MSHSPPTFTTLSLPIHTEILERLTGTRYSRGRKREFYAAVKAREALTPLSRELVQEKLWADLLVPIKRLGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Z3</accession>
    <name>U4L2Z3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935567">
        <property type="protein sequence ID" value="CCX10837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2Z3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="98" mass="10473" checksum="27C129E4C833ADC0" modified="2013-12-11" version="1">MPCFGSHPKCAVNPAAVDPPSLGRSTKIKSPGHPTIAPKASRYNTSVSKPSIPRVYTELSATVCEDPTIAKASQRSQDAEPLWLMFAMKTGVRHLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L319</accession>
    <name>U4L319_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_09348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935495">
        <property type="protein sequence ID" value="CCX09755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L319"/>
    <dbReference type="STRING" id="1076935.U4L319"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GREQKMT"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX09755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="662" mass="71706" checksum="1A35B12D28126608" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L354</accession>
    <name>U4L354_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polynucleotide 5'-hydroxyl-kinase NOL9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_09388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L354"/>
    <dbReference type="STRING" id="1076935.U4L354"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EHVWKVR"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057573">
        <property type="entry name" value="NOL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24419">
        <property type="entry name" value="Cupin_NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NOL9 N-terminal" evidence="12">
        <location>
            <begin position="224"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="361"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX09795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="711" mass="76053" checksum="DB19822D7C675DB0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L398</accession>
    <name>U4L398_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935313">
        <property type="protein sequence ID" value="CCX06788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L398"/>
    <dbReference type="OMA" id="GYEIHSH"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651618" evidence="2">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="26948" checksum="E7F720ECF93669B7" modified="2013-12-11" version="1">MKFTTLAISFLVAFAAAAPHGGRGQNQNQNAGTDVDTTYGAGNAAGTGAATGTGADVANGTGPATGSYTSNNSGANAGTNTDTTGNGTATGADNSTNVAVPDASSSDAADSSNNSNTNTGAGAAVGDVTNLVGGLLGGVTGAAGGAGGAGQAPDISNLLNGVKTLLGNAGNAAGGVASGAGNAVDGAVGDATGAVGGLGQLLGGLTGGAGGAQGGLGQLLQGLQGAAGGAGGAAGLGQLLQGLKGAAGANGGAAGGAGGLGQLLQGLKGAAGNGAAAAGAANGGEAGNGAAAATGVATGVATGAATYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3A2</accession>
    <name>U4L3A2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_02601</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="HF935207">
        <property type="protein sequence ID" value="CCX04525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3A2"/>
    <dbReference type="STRING" id="1076935.U4L3A2"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITHDMVV"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="411"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="518"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="843"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1011"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX04525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114877" checksum="0EC760A5844053D4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3D5</accession>
    <name>U4L3D5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3D5"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="123" mass="13753" checksum="E6FE8CF943B6A747" modified="2013-12-11" version="1">MYEAAGYGREEIGGKVALVVFGYTTDMPYTAFLLCFHLFSRPELLEKVREKVKGKEVEGLQDCRLMKAAWLETLRVCTSAHSVREVVSDTVVDGFLFKKGAMVMGVSRTPQTAPEMWGAEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3E4</accession>
    <name>U4L3E4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935591">
        <property type="protein sequence ID" value="CCX11096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3E4"/>
    <dbReference type="OrthoDB" id="5427804at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="12116" checksum="968D028B97FAD483" modified="2013-12-11" version="1">MLCGAIMAPSRLDDRNKAPDVREAWRKFFHEKRELIIRSFEKTGIALPMDGSMGSDIPISSFTPDKISKLSFGRYCTHYESQKKADRPRTKRQLRLKRQRVYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Q8</accession>
    <name>U4L3Q8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ribosomal RNA-processing protein 7 acc. no. O94683</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935214">
        <property type="protein sequence ID" value="CCX04690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Q8"/>
    <dbReference type="STRING" id="1076935.U4L3Q8"/>
    <dbReference type="eggNOG" id="KOG4008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GIHKWIA"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="161"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="278" mass="30769" checksum="DC8B903810152F85" modified="2013-12-11" version="1">MTKQPSDYTSLYLQLDSGVQHTLHLRRHSPRVPSAEDARSLFAVNLPVDATEAQLRSLFTSIGGGRVETVVWDTELLATSTPAPPISNKKRKLELEAPPVPALPSVNALHSTGSTAVIRFIDAASATASLQAASKATAKKPAVLPDATPLGLARYTQLHRARFPSTAVLQANLDAFIMGFEASEEAARIAAKKRAVADEDGFVTVTRGGRNGAASMEEAKRMLEEKRKQEEENKAAGFYRFQLREERKQKQVELVRRFEEDRKRVEERKQRRGRVVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4G3</accession>
    <name>U4L4G3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4G3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8805" checksum="25A5E2767E9600DE" modified="2013-12-11" version="1">MSDSAGCQAGSSDRYNEYGQEVSTYDSGNCGSYAQKEGRRDLPHTGRGEGGLRLSAIIELMIFWRFNTGMRCWRRCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4K4</accession>
    <name>U4L4K4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4K4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="3889" checksum="52F19812B689D911" modified="2013-12-11" version="1">MEASCDVLPGSKMSKVPKTLQKLQSFVLLPFVRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L545</accession>
    <name>U4L545_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <taxon>Pezizomycetes</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <end position="408"/>
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            <end position="23"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6L6</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
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        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
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        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
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    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="514" mass="57105" checksum="200F188364FC1684" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6W0</accession>
    <name>U4L6W0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6W0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="22939" checksum="8A49CF0677D4B21C" modified="2013-12-11" version="1">MSSGSMGSLSSLPLSHLVLSSAGGYCRRKLKLKLVKRLSRIQGLLYFRCRHIRALSHRRPTAIGSSPTPHNEAWALQLCSFTASRLCELRIRYSPSGFRLVSPELLTHTLDAPCYIQFCTLKQHSNANHRSDTFAVSHRSTLSQHCCPVRTLSTVTSGSIGSFSSLSASFCSARNRPSTRLTSVSSYIYSLLISNNRFSRASAGIEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L712</accession>
    <name>U4L712_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Protein SERAC1 acc. no. Q2TBM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L712"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="8">
        <location>
            <begin position="321"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX13199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="433" mass="48884" checksum="63B948C7C6C891B1" modified="2013-12-11" version="1">MKYIYGRAMGKLRHDQYRIIAITGLSAHAFGSWKSPDQADTMWLRDFLHLDFPDIWVLTWGYHSGIKDDRSTNSITALSRKFLVDIKQVRDKEVIVLRILHLGGLVLQKALVDASMGDSAEDKAFHQSCVGVLFFGVPNQGLNQKSIDYLVQGKGNKSFLQQLSSGSDYLFELGKDFKICHENINSIIVSFYESEDTCSVENIPDCGRERRGAPIRMVAGESAVCSASKDYNIIEICADHFRMVKFRPKYDKNYQRVIIKINKMMMVNHEAKLSKTSLTPVETVSTKHYKMCKVQERLQGGSSDSKPHKKHQDIQQERLEGTGNRFLLQPQFQQWCDSESNDDNVGSAVLACSGIPGAGKSVICSFVFDTLYTKFSPEERVCVVCLYCDYRDDKNLTAVNMIGVLLKQVLARLNKSGLLPPDTISALREHLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L748</accession>
    <name>U4L748_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L748"/>
    <dbReference type="STRING" id="1076935.U4L748"/>
    <dbReference type="eggNOG" id="ENOG502QS3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="250" mass="27107" checksum="797A1F3E1F499CDA" modified="2013-12-11" version="1">MRPTLRLLAARIAIPTNTLFPRVPSVPCPPPSTPPCACNPEGLDIDRETPLMGTMPRYGKHLVVATGVSDWPSKIEMDPKNELAGKIKAVMRSKGDPFNPTLVTNSSLPGGGVYEFPAGRFYPADELSSLLSTGELSPDAHTLKHATVLICSHNSRDTRCGSYYPILKKEFETVLKREGIEGVKVEGTSHLSGHKFAGNVVVYLPQGWGVWYGRVGVGEVEGIVRETIMGGRVLKGLTRGVVGREMEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L763</accession>
    <name>U4L763_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_08070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX08477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L763"/>
    <dbReference type="STRING" id="1076935.U4L763"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX08477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="163" mass="17654" checksum="71D3439FDCBB4956" modified="2013-12-11" version="1">MSIKAGDNFPEGVTFSYIPYMGDDITTCGRPIQLKASEDWANKKVVLFSVPGAFTPTCSEQHLPGYIAKLKELKAKGVDVVAVIAYNDAFVMSAWSKANGIKNDEILFLSDDEAKFSKQIGWTAGLRTARYALVVDNGKIVYAGRDEPGKLEASSAEAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L773</accession>
    <name>U4L773_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_05467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L773"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5202" checksum="E370625D005CBC68" modified="2013-12-11" version="1">MSSLAVPAWYLPGFCFGGAPLQAFSGLGRRWRVIVDECPDGLNWMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7V7</accession>
    <name>U4L7V7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651727" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8536" checksum="1E3BB0607FED9902" modified="2013-12-11" version="1">MPCSRCIVFRVVVLVAAAGGSTGVPLRWQHVLHLYRRPRALGTLGRDEKRGTQESGMLRNSNLMADQHKSTMHSHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7W0</accession>
    <name>U4L7W0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to PHO85 cyclin-7 acc. no. P40186</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L7W0"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDRQHDH"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="386" mass="42237" checksum="247D0FD7CE83FB01" modified="2013-12-11" version="1">MLQVGLRSENIMITHPEPREHHRPPLPHTSSTPVSEQWPRSTTSSSSVTPNPQNPSTRQQPATVVRHHGTGTSARPQNPTPTTLLPEGSTAASTPAVAVSTAPSAAPAPATIPTSPAPSVTSLASRDPRSGSLSPSRKSDVPSVPPRSPPTVLRNLDHIVQLAKEDAAASLPSSPTRRRSVVNDTRRYEISSMPVGDVIEMVAALLTKITTTNDKQHDSLRLPSADGGHTMNQTTNSVLAFHGKNVPSITILSYLSRIHKYCPTTYEVFISLLVYFDRMTERVNKRNAEGDQQQDGRHVFVVDSYNIHRLVIAGVTCASKFFSDVFYTNSRYAKVGGLPLQELNHLELQFLILNDFRLSVPVEELEAYGTMLVQFYAREALAKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8P0</accession>
    <name>U4L8P0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <dbReference type="EMBL" id="CCX09718.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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        <location>
            <begin position="1119"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM01272"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX10457.1"/>
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</entry>
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    <accession>U4LA35</accession>
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            <fullName evidence="3">Similar to Putative aryl-alcohol dehydrogenase C977.14c acc. no. Q9P7U2</fullName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="226"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="304" mass="33961" checksum="27EC268B4A74E487" modified="2013-12-11" version="1">MSSRLPVSLANAFSTLRITPTVPAVRNFSTTPAQLKRKIVRVTFNPHALAASKKRREANVSRQRVLQKERDAAAVDPVLGRETEFLKSLAVVPPPLPSVDAVQNHSAKLPSPEEQRLNHFLANREFSEFMSQSRTLTDPYSGVGDKFQDKDNQAAFQAQHEHSVEAIRRIISLSNGNSGDRTRANKQMVINMFGRHTTDSILPKDPSAPATSNKTPRAGPDTGSSEVQAAILTVKIRALAKAINREDGFETKDKHNKRNLRLMVHRRQKLLKYLKRKEKGGIRYRNVMDALGLDDAAVENELFL</sequence>
</entry>
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            </authorList>
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            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX16185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8972" checksum="5A0E1CE1BB9E7046" modified="2013-12-11" version="1">MRGKDRYGEIRSTIINNPVHYAGHSELDKYRNSSNAIIFWLSLHGLRESRSISRQSIRNSRTTLGILTLHLRIIHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBM9</accession>
    <name>U4LBM9_PYROM</name>
    <protein>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16200.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="451" mass="49782" checksum="40FB5E0E00A2CF1D" modified="2013-12-11" version="1">MESPTHQVQRERHLERETLTDSLTTLKSLLRLEADGIGDREDLLDELERARQTIERFSITLRRQTMMISTTPPNGGFEVIHGNLNGGGITGLGGIGGLGGLSGLEEIRGDLMNGRRESLRDSIRARSLSQSSSKSSWRSSASSVSTAPTSVSSRDSMGGNRRDSLHNRRFTGSPSPYLSKLREEEFRFTDDVVVEEEEEMEARDQFAEVDLNEQDEEVYEEDEEEEEEQEEDYHDESFERLSNILASLQKQAETAISSPTVFDGAPSPSPSPTPSEFWGDASGVSGGVSHSAHHSTSSFDRIACRRVASTPGLRSQALAALTRKSPSPTPLDFNSITSHPRHRKSGSASPHIPHSSTFPTSTRIPSNPNQPPTPGVLKKRNSRPPSGIEMIKKWEDLEGLLGELLEERMGRQGDWVFGVVWIWLVSGGFLWWCVGMMLGWGCDTCAVPTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBN8</accession>
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        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBN8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
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            <end position="101"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="520" mass="55138" checksum="1DF20F19A6E0EB88" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBP3</accession>
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    </protein>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBP3"/>
    <dbReference type="STRING" id="1076935.U4LBP3"/>
    <dbReference type="eggNOG" id="ENOG502S7AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WIPAKRD"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="324" mass="35667" checksum="EBBDADE1FE14DB03" modified="2013-12-11" version="1">MPLSLTSLNGDSAFLLTFTPSSNNGATITVLLDPWLHSPASIIHPRFASQSLIAVPVISSLSSLASAKLKSAESVESATEPAAESGECKSPPDAILLSQADSDHCSPATLSEYPWSLTPTEVFCSSESAGRIRSWPWWREAGLDGRLRILKQKKPLALTKVGFTTAGESTSGESKLEVELLEAKYPWQIPSVHSAIAITFSSREEVIRVLFSPHGSPWGCVKSWVGNKKLDLLLWPWHHVNNPWWLGGEVAAGFECGRKVCEATEVSHWVASHDDDKEVSGWVTRWMVTRFWGEEKVREHLRERVGLWRLKAGEVMTVGGKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBZ7</accession>
    <name>U4LBZ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBZ7"/>
    <dbReference type="STRING" id="1076935.U4LBZ7"/>
    <dbReference type="OMA" id="AWINECE"/>
    <dbReference type="OrthoDB" id="4160836at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="38025" checksum="B3BB83F232C9B3EF" modified="2013-12-11" version="1">MSSSPSLPRRTIASSKKPFHDARQQPYPPRQAREELRRTPPARPSQQSKEPSDEVLRPVLESINSEIAALQREIALLEREERAQTKKPTDTEELISRLLAANDSHLTVPKPPKFSITAEADIPSALPLPTDKPLPQLKMFSSITYTSCNTTIEPSDSSILRRQSIRGYVGKFGVSMLDFHLDLRILGDQVVDLSAKVPIWARKDLGAWINECEETLNPSYLLYALNSYHPLAVKRAATFAAMSKRYTELTRQLKKAAWMGVDTMVFRWGKEGPEVVVRWQLEVGDMGDVESKLTAGVRVPGVYAEDGEWVRIAGWFSEMVEEVGVRKAIEATVQAVLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCB6</accession>
    <name>U4LCB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5429968at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1582"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1838"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1845"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1879"/>
            <end position="1890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1912" mass="214087" checksum="75322A8EEA571E9D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCK4</accession>
    <name>U4LCK4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PCON_07782</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CBS 100304</strain>
            <tissue evidence="26">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="HF935394">
        <property type="protein sequence ID" value="CCX08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCK4"/>
    <dbReference type="STRING" id="1076935.U4LCK4"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISWEWAL"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
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</entry>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29913.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="170" mass="19224" checksum="FB933EC3850D8EDA" modified="2013-12-11" version="1">MDQSIELSESQLGHYVDYLLACFEDVDGVVKLDNPDAQDTSNQIRNVPTPIDFSGLNLKIPEFTTSPSAHNSTNNSDTTTIVENVQGKIDQIMNGLLTGDELLLLLDVRSHIHALEHLIHVERKRIEELQAESFQLKCQVDSYQKLFAIAMEDMDMINYQPVPAESYEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDS2</accession>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
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        </location>
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    </feature>
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            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX09244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="42738" checksum="11BE401BDD5F33D1" modified="2013-12-11" version="1">MFRPVAATLPDAVANTMPLNPKTHVSFRITLPVTTHANRVDVVGSWDQFRTSVQLEQDKRVGMDVWKGILSHNGGLEMGSEHYYYFLIDQTRPIPDPHSPPTSLVMDHRTGRLMSLLYVPIELPPSRSAPSTPSSLLETSISPCTPVTSSIFTDFSDLEFEFPREAPSATPSFSGSTSAANITTLQRKGTFRDRLRQRLEEPRRRGLLSVSTSFLRRAYKQGEEEAMLPPPRAPSDSSRLSREEEMREMAGYLRSGASSRRSHYSPPNPHLPPHQPVHAPQSSIPEPDMYSSFYSSEDDDEDADVEGEDTGMEEEEEEEELATPVDDTEAEQLPRYYNFDEVKPLGHGESLSCLREHVQGEVKWRREMESELGYLGSVVV</sequence>
</entry>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="4">CBS 100304</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="917"/>
        </location>
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            <dbReference type="PROSITE" id="PS50882"/>
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    </evidence>
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    <sequence length="931" mass="106317" checksum="888567E26CAFC9DC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEW8</accession>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="54"/>
            <end position="74"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="108" mass="11519" checksum="E5E85703C1518F42" modified="2013-12-11" version="1">MQFQSLHKRSESSGNDNALTPDGTSAIVIGILGLALTAISIYVGVRISRTVSTGHGIDIERNPSDPDFTADQSPLPSQLLRTARSANVESSFAPVVNENRALTWPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX10042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF21"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5751" checksum="0E0F457888DE13EE" modified="2013-12-11" version="1">MACQIFPFSPVVTLSVSNYVSLRKFAHAFAISFLFSRWFLCPSNSASCRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFD3</accession>
    <name>U4LFD3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Polarized growth protein rax2 acc. no. O14239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_09187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651959" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="223"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="377"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="904"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1232" mass="131200" checksum="5700C8FED1D606BF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFF6</accession>
    <name>U4LFF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to KIN17-like protein acc. no. Q9Y7X9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFF6"/>
    <dbReference type="STRING" id="1076935.U4LFF6"/>
    <dbReference type="eggNOG" id="KOG2837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QVCERQM"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="307" mass="35605" checksum="E202608030A8F94E" modified="2013-12-11" version="1">MPRAEVGSTKHLANKMKAKGLQRLRWYCQVCERQMRDENGFKCHTSSESHVRQMLLVGEDPKKHIENYSNQFKRDFLSLLRTSHGEKKIDANRFYQEYIGNKEHTHMNSTKWVTLSEFVKHLGREGTCRVEDGERGLMVAWIDNSPDALKRQEIVKRKERMEKGDEVREQKAIKEMIERAQQQKREEEDAGPRELVREEGEKVKLELNLKKAESPKAEEAEGKKGGEVEVKAVETKAPARVSMKIEMKPKKNVFASMGKKDKKDDKKRPAESSDKPKRPMSEAERIMKEEMEKRGGVGGVFKRPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFG8</accession>
    <name>U4LFG8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFG8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="16" mass="1884" checksum="4F625350ED8DE06E" modified="2013-12-11" version="1">MAKVTAKDRLEYSRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFL5</accession>
    <name>U4LFL5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935433">
        <property type="protein sequence ID" value="CCX30302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFL5"/>
    <dbReference type="STRING" id="1076935.U4LFL5"/>
    <dbReference type="eggNOG" id="ENOG502S4EU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QCIHEPF"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="38586" checksum="6DFF36918BD42165" modified="2013-12-11" version="1">MAATACYPDPPITPSPSPPQTYPTNDRPIFMATHPRACSTAFERVMMTRKELNCVHEPFGEPFYYSNTESMGKRFNGDGMKETREKTGHAESTFGSVWGGIEKEKASKRVFIKDIAHYLIAPSSYEGEMSLSPSLQLIANLTKRQTKSSLPNPTVVPLPLLRSFQWTFLIRSPLRSIPSYYRCTQPPLSNMTGFTYFMPEEAGYRELRMLFDYLRSEGIVNDSNMFVLDADDLLENPEEAIRRYCDVVDIEYKKEMLSWGDNDGCEKFEKWKGFHEDAIGSSGLKRREKKERKGLEEEYIGWVQKWGKEAAEVIKATCLECWEDYEHLKGFKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGE5</accession>
    <name>U4LGE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein RF_0381 acc. no. Q4UMH6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935458">
        <property type="protein sequence ID" value="CCX30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGE5"/>
    <dbReference type="STRING" id="1076935.U4LGE5"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMQDGCT"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="336" mass="35524" checksum="265968289261E4C6" modified="2013-12-11" version="1">MMKWLTSTPAQSNARNRDEWAALQVASRIGNVDIISRLLNSGADINVWSSRHNGRTALQAAAGNGHVAAVNLLLERGADVNAPPSEKSGRTALQAASETGIMEIVDQLLKLNANVNSDPSVFDGRTALQAAAESGHRDIVTHLLERGADVNASPSDNSGRTALQAAAGSGFLEIVDQLWRSGADINAPPASQNGRTALQAAAESELGAVITVPDGSTFERTALDYAKLNSHDNIVDRLHAYRRHGWTALQLAARDGRLDIVDRLLEAGFDVNAEAFEQDGRTALQAAFEGAHWGIIDRLLAAKADINAEAAAESGNLDLINKALGLGADVNNRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGE9</accession>
    <name>U4LGE9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ubiquitin-conjugating enzyme E2 J1 acc. no. Q9JJZ4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGE9"/>
    <dbReference type="STRING" id="1076935.U4LGE9"/>
    <dbReference type="eggNOG" id="KOG0428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YAQPLEH"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="33708" checksum="A32333121CA71EA2" modified="2013-12-11" version="1">MTSSEAPSYNKKSPTVKRILREAAELASSPSPDYYAAPLESNIFEWHFTLRGPPDTPYANGIYHGKITLPPTYPMRPPSFRFLSPSGRFEINREICLSISEHHEDTWQPAWGIRTAVVALRGFMETEAGGQLGGLECGEEQRKTMATESRDWTCDTCGKRSVDILKESEEAAKELNMDGRVEDEVPKELKFKVKQENGETVAQTNSAETLAPTIPQSLQTSFEAGAQSSANTGTPTTSQPPVHILVPQPPAMPPNFDQNFAPRPHQQPDTSEDNFWLDRLIVVLVGFFIAVVLQKFMGLPRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGF6</accession>
    <name>U4LGF6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936136">
        <property type="protein sequence ID" value="CCX15150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGF6"/>
    <dbReference type="STRING" id="1076935.U4LGF6"/>
    <dbReference type="OrthoDB" id="5373954at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60469" checksum="F653F683ECE2EAA7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV7</accession>
    <name>U4LGV7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Kumar A."/>
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            <begin position="1"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCX11108.1"/>
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    </evidence>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <end position="149"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="364"/>
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            <dbReference type="EMBL" id="CCX31248.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="810" mass="90043" checksum="E36750113AF120B4" modified="2013-12-11" version="1"> </sequence>
</entry>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TRP_N"/>
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        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
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        <source>
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    </evidence>
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</entry>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI12"/>
    <dbReference type="STRING" id="1076935.U4LI12"/>
    <dbReference type="eggNOG" id="KOG4555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEISKCM"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="231" mass="25500" checksum="E5E945B7F09DED2D" modified="2013-12-11" version="1">MSSATILPTGAPSLSTRDATTLTVLFDSESATALHPTIPINPSLPSNPQYPSSILSHIKSLEHSAIEISLTNPSLALEPFNTLLVAYPLYASGYNNRAQLKRILKHPSADIKRDLQLAIKIATGTIVDNEISKCMQKVLQNAWSQMGIVFMAENDTEKAVQAWMEGAKYESTWCRRMAARHNPVARLCGMIVKDAMRREMGQGEERRVEVRDNDGRAELNVQCGYTLVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIP8</accession>
    <name>U4LIP8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="6">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_11813</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="19">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="6"/>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIP8"/>
    <dbReference type="STRING" id="1076935.U4LIP8"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KAMMPDY"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="584"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="696"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCX12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="940" mass="104055" checksum="3458520705D72D2D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIS0</accession>
    <name>U4LIS0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neutral protease 2</fullName>
            <ecNumber evidence="13">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_11462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="13"/>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIS0"/>
    <dbReference type="STRING" id="1076935.U4LIS0"/>
    <dbReference type="eggNOG" id="ENOG502SGF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEIANCD"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005147620" description="Neutral protease 2" evidence="13">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX31818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="360" mass="37566" checksum="77F9AF0ACB1130AF" modified="2013-12-11" version="1">MVAFFSLGLALLAAFAAATPIEKRSSPLKVELASTSENAVVQATITNTGSSDLKVLKHGSILSDAPIRKLEVSAGESALEFKGITMSYALDKLTAEDYVTIPAGQSVTTTVELAGLYDLSSADSYSISATGAFQTTHDTGSEVSIMSLSGPAAIEFESNKLDLKVDRAAAAKVESLAQKLSKRVILSGCSGSRLSAVQTALSNTVKRAQAASSAASSGSATKFNEYFKTTSSSTRSNVASRFNAIASAASTTNSGRVTYYCTDPYGYCSSNVLAWTLPSSNIMANCDIYYSYLPSSTGSCHAQDQWSTTLHEMTHAPGVFSPGTNDNAYGYSACMGLSASAALNNADTYALYANAIYLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJG1</accession>
    <name>U4LJG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJG1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="16568" checksum="94A58BDFDE633618" modified="2013-12-11" version="1">MLFSCPTPTRSGNLVVYYFYSHFRSPCRFHVSYSSIWEASIAALWHFDYGVGNISADGTSLVGNKLLPSVTTNDYGYPTYAIPHGTPGEMIPLGENCEFVKSWVQHVDWDPRLMVAEIENDDDEPSGVILENWEQWSEFYFGFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJJ9</accession>
    <name>U4LJJ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJJ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="9248" checksum="E8CF4E2624B166BE" modified="2013-12-11" version="1">MCSGLTPPNPTRHSLSSSSTFPRFVLPRRVTHLLRLSRLRQPTSAYSVRCFRHERRRNQLLVLLCRNQSFPRLTLSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKQ3</accession>
    <name>U4LKQ3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">PCON_07737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKQ3"/>
    <dbReference type="STRING" id="1076935.U4LKQ3"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MGKCERC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="63"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="431" mass="47934" checksum="E7C8E2F54A733476" modified="2013-12-11" version="1">MTSSTPPTLDPKRACAHCKTERAKIKRAKTDERLCIPCFITIFETEVHETILANKLFHRGQRVAIGASGGKDSTVLAAVLKTLNERYDYGVEFVLLSIDEGIKGYRDDSLETVKRNAEQYGMELKIVGYNELYGWTMDQVVSQIGKKGNCTVCGVFRRQALDRGSGMLGVSHVVTGHNADDMAETVLMNLLRGDLPRLHRCTCIVTESSSSPVSRSKPLKYAYEKEIVLYAHHRKLDYFSTECIYSPEAFRGSARSLIKSLERVRPSAILDIVRSGEAFAEMVPEEIRGSACAGEKKIVDATGKEEEQTGCGKGLSQGGEMSQFEKQLQENEKAQDREVEIKISPPSITLKEKKKTPTPTKATKVTKKQQLGQCRKCGYMSSQELCKACVILDDLNKNRPKIEVVLDEEDEDASSSVRKKMEAIDMSGVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKR4</accession>
    <name>U4LKR4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKR4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="15387" checksum="7C82415A75F96BF5" modified="2013-12-11" version="1">MASTRRNRGISYADASIVQHHRYCNTSAGGPIYRKIRDAYPEDTETARSSVAAERAILRLALISILNLEFVGAEYEGRLLPLRIVVDFGHHEIFIMRAVRLVNMYETPDAIKSLYEQFQIGAQSYLNPQRWRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLG5</accession>
    <name>U4LLG5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to 6-hydroxynicotinate 3-monooxygenase acc. no. P86491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLG5"/>
    <dbReference type="STRING" id="1076935.U4LLG5"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MYTERET"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="412" mass="45848" checksum="CE37241587A3B78C" modified="2013-12-11" version="1">MPTPESAIIIGSGIGGPLCALALYRKQIPVCLYESRSSPETLGGAINLTPNAIRILAKFDLLPKLLSLGCSVTKLQFFSAHSGAALGTISFGSIEQYGFESLRVCRSDLQRVLLESIAEKGIEVRYNKKLVGVEEDAVGGEHITAVFSDGSKETADLLIGADGIHSTVRRSFVNPGCDATYSGICSAYGFASWDKVAKEGIEFDTTALAVGRKGSFLMSFCNPEKTRVFWAVVMAVAEGEVPEREDAGWRVRDEGRTKSEIVTRFDDSEKWRETVRTAVMAEDETFFFPVNELPAEGRWWRGRCVLIGDAAHAMPPQGQSIGLAFEDAVILARVLGEMKDEATVEERLRRYDELRRPRVAAARKEAAKSRESLKEVHWFVQWCREWLYWFFLAVFAKHSETAFMYDAEKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM92</accession>
    <name>U4LM92_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized membrane protein YMR155W acc. no. Q03795</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX15005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM92"/>
    <dbReference type="STRING" id="1076935.U4LM92"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PQDNETH"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="522" mass="57121" checksum="9F2DC7D8E0B793DC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMJ3</accession>
    <name>U4LMJ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein vip1 acc. no. P87216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMJ3"/>
    <dbReference type="STRING" id="1076935.U4LMJ3"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQEMKPR"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="292" mass="30965" checksum="1238C4FE90EAE214" modified="2013-12-11" version="1">MTGSTVHVKNIASSTTETELTNFFSFCGKITAHTLTPESGAPDSPLSATITFNSPSAASTAVLLDGTPLNHVPLQVTAAHSIEEIAGSHLAPTAAIGPDGEIPQEAKPRSTIFAEYLASGYLIGDTALHKGIELDKKHQITPKFAGALTSAFNFVENKLGATQRARAVNEQYHVTEKAWGFTGGLARYFEKALDNPTGQKVRHFYESSEKQILDIHTEAKRLAELKKEKRRSRSGSQEAGFACSCPGITGECSCEPGSCKCEGCSNKMAAAAAAKEPTPAKPAVDEKPPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMS3</accession>
    <name>U4LMS3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to ISWI chromatin-remodeling complex ATPase ISW1 acc. no. P38144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_01728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMS3"/>
    <dbReference type="STRING" id="1076935.U4LMS3"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="178"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="474"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="839"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX15453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126905" checksum="7698D29546E2ADF8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMT8</accession>
    <name>U4LMT8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized mannosyltransferase C1773.08c acc. no. O94565</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936188">
        <property type="protein sequence ID" value="CCX15507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMT8"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YNDFFEM"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="496" mass="57849" checksum="F541F1116867B48A" modified="2013-12-11" version="1">MGLVRQIVQLLPSRKKLDEIAQYHRLSPRLAFLRRRIRLKGSSTVTMPLGAVLMLPFTILILVLFLLVRHPDSPGRKLMPSSSPPAIRKISEKFDKPFVTGCSVPQTDQPRENAVIVVLARNKELEGVLSSMRYMERHFNRHFNYPYVFLNDGIFNETFKEAIRNYTQSEVEFGQIEPEHWGFPDWADLGEAQEAIAKQGDQAIMYGGMASYHHMCRFYSGFFYKHELLAKYEWYWRLEPDIKFYCDMTYDPFVEMKKNNKTYGFTIAVKELRETVPNLFRYSSAYMRNNNITSQGMWEMFAEPKPAKKEEEKNKDNLPEDVLKLEPGRGKPVEVDPTAMEGEDYNMCHFWSNFEIARLDFYRSKEYEDFFQMLDKSGGFWNERWGDAPVHSIAAGILLSPAQIHYFRDVGYRHTTIHHCPANAPAKQLPRQKWYEPYFDDKKAKEEDSYWDNWDAEKENGVGCRCRCDTDIVDIEGKKGSCLAEWVKVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN21</accession>
    <name>U4LN21_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936252">
        <property type="protein sequence ID" value="CCX15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN21"/>
    <dbReference type="OrthoDB" id="10564849at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="301" mass="33726" checksum="9E9338D1A6D9E708" modified="2013-12-11" version="1">MAFSSSVANAAFQASMNLHKISMGMVSMQIDTAASEPTLPDSLVPLTQSFTRSCAIEERCHKFLPKDYPPRAPPADPLDELKALVHRMQSRVKKSNNPPAIPIHPAPHSAKYSVPVEPLEPGTYITAANIRVVRLPYIRRGIARLLPAGRIQLLFYNDNGNCKEVYVNVSDIEDLGLRKTRDPPEGKTFTVKELSCLYHVGRAVPKVHTVDRKAQLDERRRKIKAKENALPRAATNKLNAELLAMGVNADWSVKEWYFGKTFRGEDGNKYTNPEMAMAERVRLCLCYDTTADFTNEEISDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNA5</accession>
    <name>U4LNA5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNA5"/>
    <dbReference type="STRING" id="1076935.U4LNA5"/>
    <dbReference type="eggNOG" id="ENOG502QRKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="492" mass="57617" checksum="403BF514561E478B" modified="2013-12-11" version="1">MDSPLVSSLFRSLRHHRSCLTRSQLQHIRAPRRTIVSLRPDAKRAAKEGEWFAKTPFLNNDMSEEFQRYPMVTAADLARRIERPKRVKMLVRDYVDEGAEDVDALYNPHYGYFSKHAVIFETERPFDFTSMKDEMEFHHKLAEEYTRFEDKLDAVEFNPIRQLWHTPTELFKPYYGEAIARYLVTNYKLSLYPYNDLIIYEMGAGNGSMMVNILDYIRRSDPDVYARTKYKVIEISTALATLQKKRAASHNHLDKIEIVNKSVFDYDLYDPSPCFFLALEVFDNFAHDMIRYDPETETPYQGIVLCDQDGDFHDFYVPQLDPIAERFLRVRQHVVRGAYNHPLGTPKLLRKMRGMLPGASNLTIPEYIPTKAMLFFDVLREYFPAHRLVMSDFSSLPDSVQGVNAPVVQTRFERETVPVTTPFVQQGYFDILFPTDFEVMDDMYKALTGKLTRVMQHEDFMQRWAYLEETETRCGENPMLGWYKNVAMLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNC2</accession>
    <name>U4LNC2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936091">
        <property type="protein sequence ID" value="CCX33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNC2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7097" checksum="FF15D55B08BA24B9" modified="2013-12-11" version="1">MVIFARLRPESPKIIIPYSALMSYLAMETTILHEPHVVVEPCSSRPNPSVLGMGIKAATSSGISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNH5</accession>
    <name>U4LNH5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNH5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="12325" checksum="39F09AA6E0EA9A94" modified="2013-12-11" version="1">MRGSHQRRFHPSLLHPCHGFKEKVVTVKCYETVILTPSFCFCLGLVGVEIRPFCIYPEIAHMPTTRTGVTVKATKSYAPSRKMSDEHRRRPRSHHPKSEPLWKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNP9</accession>
    <name>U4LNP9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ankyrin repeat domain-containing protein 29 acc. no. Q8N6D5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNP9"/>
    <dbReference type="STRING" id="1076935.U4LNP9"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047184">
        <property type="entry name" value="KANK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168:SF21">
        <property type="entry name" value="KANK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="192" mass="21078" checksum="9D7640C9E3FBDCC3" modified="2013-12-11" version="1">MPPYKMRERGRPALIYASKHGYADFVRLILQRTEIEINLQDRGGKSALLVATKKGHIDVVRLLLEREDINTSLKDGKGYTALLCASHNGHQEIGNDGDPALMCAALAVHTDIVRLLLGRAEINTSLKNKKDDTALSIAIEERHTEIINLLKEHEQALQAKENETTASAGTEVSETAPATSVPPSDKTIHPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNT5</accession>
    <name>U4LNT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNT5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652511" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14336" checksum="B6A133B50A096C9D" modified="2013-12-11" version="1">MYLPTFFLLLLLLLHFQLTTAVPSLMNPHVLPTSCRPGHTPIEKILPMAYALQNRRGEYCCVKDFCTPAARNKGALVLLCTKTSEELCIRCEKVGMAVMQAVAHCHKDGKVDGRVVFREMGLEVAVSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP19</accession>
    <name>U4LP19_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Altered inheritance of mitochondria protein 6 acc. no. Q75E59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP19"/>
    <dbReference type="STRING" id="1076935.U4LP19"/>
    <dbReference type="eggNOG" id="ENOG502RXNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRVRFWA"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651531" evidence="2">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="314" mass="34267" checksum="85C5B84463803227" modified="2013-12-11" version="1">MKFTTLLTLAAAALVSAEYSQSSKHVPGIQHVLENWNKSPLASYPTDFTRGIIPKRLHSHNDYWRDVPLYSALSVGAISVEADVWLYGDTLYIGHDTSSLTPARTFSSLYIDPIVSILEKANPNHRFAHDTKNGVFDTSVGQTLYLWVDMKTSGPETLPAMIKALEPLRQKGLLTTLEDGVVKQGPVTVIGTGNTPMDLVQKETKRDYFFDGPLKTLKEQNVTKELSPIASAQLSAVTGEVGVDGLTATQIDAVKAVVAEANGRGIEVRFWDLPGWPISTRNKIWLQLFEAGVYLLNVDDLEAGAGLGGIGAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPD8</accession>
    <name>U4LPD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPD8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11674" checksum="5875A8FAA1C293FF" modified="2013-12-11" version="1">MTWPVQIVRLGYGLPSLHVYRFVQCFRVSPLLILVAIPRADEHEMRPTRDYCPRLWDVTLKTGILISTVHNITRPLFTAIISNIPDRSLVTKLHEEPEITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ31</accession>
    <name>U4LQ31_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ31"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="2230" checksum="1AB5F8BAFB77A9BE" modified="2013-12-11" version="1">MDLKRHPRRIPYGISNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR33</accession>
    <name>U4LR33_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR33"/>
    <dbReference type="STRING" id="1076935.U4LR33"/>
    <dbReference type="eggNOG" id="ENOG502S5ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDCHTIE"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651707" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="31934" checksum="0923DF96743EA662" modified="2013-12-11" version="1">MRLSTIMTAVAVIFPCVSAHGRLKYPTPLNAVSDDVASNIPYNSPLKPDGSDFPCKGLHKTADLTKGTEWKAGQDTYFEILGNGPGGSDTNIGTLAAHSGGSCQASISFDNGKTFKLLQSFMGGCPRGVKLNSNYASNPDQKFHFKIPEDAKAGPALFSWTWIAVTGNRDEFYQNCAAVTITGSGTSTLQDAPDMFLGDMSIGQIKAGECRSTAGSNVEYPNPGPNPIKDTTSGIPFKAPTAGQCFAPGSTSGSPPAPGAPSAPTPPGGAAPSTTVPSPERPPTKTASIRPTISLDVTGDQCKCQCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR94</accession>
    <name>U4LR94_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative 37S ribosomal protein S26A, mitochondrial acc. no. O42919</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR94"/>
    <dbReference type="STRING" id="1076935.U4LR94"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="266" mass="29874" checksum="08D0F5671D8D6339" modified="2013-12-11" version="1">MSFSSSLLRRMPRAVSGVPKLTRNLHSVPLLNHKETFTNNGIPGAFSPKAFKTSWTEYQEGLVGNLNRLVAETEFAHKPAMDIAILTARQADLAATFNYSSQAHNNHFFFEALSPVPTKMPEEFLALIPWTWSSPEALKTEFLTTAKKMFGNGWVWLVLDQTKYLRIVCTYNAGTPYGAAYRRQETDMNTTPDLSIRETTNAVKNSSVAGANWAVPLLNINVWEHAWVEDFGVNGKELYLEAVWDVIDWSVVSARFASTSARTLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRJ1</accession>
    <name>U4LRJ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936389">
        <property type="protein sequence ID" value="CCX34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRJ1"/>
    <dbReference type="eggNOG" id="ENOG502SAQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DRMGGLK"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="176" mass="19736" checksum="345E4C9A977C24B6" modified="2013-12-11" version="1">MPALYRRSSDTNDKKPHSGGPSDESMRNLLITLVILVAFCLILGVSLYILRRHRRAAKEAGTLPTYDAATRTGNRLTIQTNRDSTFIYSEKQNLIDNGSPMPISPESVPEIRITFPEEEDKDGRRISGRVVVVQVGEAGVGFVRPLEQDLPPYQRQGQERFDSVDIDRIGGLKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRL7</accession>
    <name>U4LRL7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRL7"/>
    <dbReference type="STRING" id="1076935.U4LRL7"/>
    <dbReference type="eggNOG" id="KOG4763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTCNDRV"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX29936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13511" checksum="62613FF1D3F4EAEE" modified="2013-12-11" version="1">MTVASFFADLYESLTVSDVHAEAPPAEPEAEEPAQEKEEEAEAEEEEEEEPEDPMPALLEECEKTAACAPAKHHFDECVERVTAAADDENAKGPKEDCVEEFFHLMHCTTQCAAPKLFAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRM7</accession>
    <name>U4LRM7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRM7"/>
    <dbReference type="OrthoDB" id="5338805at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="41195" checksum="F58D68E82C5E94C3" modified="2013-12-11" version="1">MADTLSRKRIIHAVGATALVPTVAAVAFFIINALSTYPHHLTLTALSIVSAALNFTSCISILLFTFLPPQKLLHRLLGAIPSVLSATVSALTLGWLVLEYNDLPPKTLGANTFHLLLAGFGTYSLLLIAQSVFWTFINISHKPAIDLETSPTFFCRSNRRTVDLSFPSTDNSCSQSVSSLTSTIHDTKNPYITRIYHTTASATSSKPTLVHKPSPTTTGFAPLQPIPDAEMPLSAGWERNHFDDWETSDISMTERVTATLAAAEREVLEEEKQYNRGRSTHRNGNGNGNGKARKARPKPLDLGLPNATHLSANFRPESGESGLSGVSQAISTATSLPERRMSPPLPLSPRNKDFGQVETGYTIAPGGTGRWLMRSRSQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LST3</accession>
    <name>U4LST3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="10" mass="1278" checksum="4BCF7FC5A2D1A1E7" modified="2013-12-11" version="1">MWLHTVSQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSX3</accession>
    <name>U4LSX3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSX3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7408" checksum="B3EC52CCF482AEE3" modified="2013-12-11" version="1">MEVWTLEAKGQRAPWVFYAIAALAKDPMLYECFDLKASQKTVTSGEVHRYLHDKAGIACVSGTETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT06</accession>
    <name>U4LT06_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT06"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="254" mass="28712" checksum="465D57841A9DDF56" modified="2013-12-11" version="1">MVTTRSQVALATSATTELQPLKPTPTLPLEFQEALAAAVQEEVLTKLLVNSVDAHAPKDPRITALSPESVTVSYKQPVREYWFKPLDQAVIIRIAPELPEVPKSCNEKWAKDVAAALKAFVEKDEVPITTFIAPSHWQEFTTLGLFLGFTFLIIAHLIGVSIVGDWIFTTEKRFNIAVAVHCAVLVKRSQDVRRLGDLLGKHWKGGRKGHMEWIMSSWLEGWRAVDRFRREVARVRFQLSTDEKKSGKETKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTD1</accession>
    <name>U4LTD1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTD1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="12329" checksum="1DF1C4727E26E52C" modified="2013-12-11" version="1">MLETSYWETMFRSYNPGTMLDADLQLEELDIPGSEGQKKLSARKNYFNTIAPNFLKHPSIFYQTYNRKEIVEIAYKDAVYLLGVGGDDNLDQESPKLQEFRPKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUR3</accession>
    <name>U4LUR3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUR3"/>
    <dbReference type="STRING" id="1076935.U4LUR3"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVNARIY"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="464" mass="49676" checksum="B3049F1D470DC253" modified="2013-12-11" version="1">MLTETLLLATTRTPTDNVDAPSISLYNLHTSTLTTSLKRSQTSSSGLAITKTHIFAQQSDKPVINIYSLFTSLLETSVSFPEPFTVLSASPCGLYLAAGTATGRVYIWELASARFVATPPLHLQKITALAWDRTGAILAVGSEDTNVSIWSVAALLDIRQAAREPLRVLDRHIHAVTALAIGPAGSGPSELLVTAGRDKNVICWELHTGTHLRTYMIQGVPLCLAMDPAERAVYTGLEEGGVQMVEFQATQSGKSDMYEGEFRDMPVQVTGEVWGGGAKVLTAQVGYEGNVLVTGDEKGECAVWDVASGGMVKSLCQMKAPLSNLLILPPTGFATTAEPTITVPTLPKPKYESILAASSSTTYDPSSYTLTISLPTSTPETTTSSLSTSSFTTSSRSTFGPENDMEEILKGAREMKAVKPALAGKQKVEALEAELAGLYQSYERLAEVQKKTWQGMVELAGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV46</accession>
    <name>U4LV46_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_03237</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV46"/>
    <dbReference type="STRING" id="1076935.U4LV46"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="381"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="446" mass="49258" checksum="FD00A3E2757EF621" modified="2013-12-11" version="1">MPPPSRANNVYGPPFPQQGAMHVGHSFDRYQQHINPQHQHPHQAQIYQHAQQVSAAARSLQEKSLLSILNQNAQSTVNRIHGGGVSAAGLGGVVTRNIGVADPRQQASMAAAMGRSSTDHDNVIRDVWADNLEREMEVLRGLVEAYPYIAMDTEFPGIVARPIGKFPSKADYHYQTLRCNVDMLKIIQLGITLANENGELAKVDGQVSTWQFNFRFSLEDDMYAQDSIDLLTKSGIDFTRHSNNGIDVYKFGELLITSGLVLLDEVKWISFHSGYDFGYLVKIMSCESLPKEEANFRTKLRTFFPSLYDIKFLMKSCRNLKGGLQDIADEMGIQRIGPQHQAGSDSLLTGTIFFRMRSQYFENKIDDSVFLGQVWGLNGNGQSQQPNGVPLDPDAQIDATGAPQPPKTPVQNGSETQGTPDHTSTPMRNATPGTPGYTPSFGRMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVE8</accession>
    <name>U4LVE8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935878">
        <property type="protein sequence ID" value="CCX32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVE8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="395" mass="43450" checksum="0E663CE03EA29FCF" modified="2013-12-11" version="1">MRAIGKEEENGILRFHKSAGFAVEKYSIITQASVRKLQQIAMDTPTTNSQENFNFLSGMATPSAEELESFCEFVLANDIPVDIESLDQLPVDLSPTDLAPPDPIAPLNFNLLPGLVHSGSLFPDMQLYPDMSLFNIPLFDAEMPNILPPPARSPDHDHVIYTHGTIPLIAVDDIQEAYGMTPVDVAPSQRTHSTRMRPCTSDLDEQNILLGSVGQTTDLESEPTRKRHKGTMEGREGPLSSSEYMDASLNEFEVPYAPDHTYSFPNIISSSPLFGSLKLLESATHCHNDTPLGRYFSEASDDEGVDKNAVELTAMEFRQSTFPDAERPSSPKYLEQADLERCPSDKSSSSAASSVCSAGSDIPLDERRKRKRTTNKALGILESQEIGNDTKTVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW86</accession>
    <name>U4LW86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 acc. no. Q6NS38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW86"/>
    <dbReference type="STRING" id="1076935.U4LW86"/>
    <dbReference type="eggNOG" id="ENOG502QRZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VITKSHY"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="752"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="945"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130399" checksum="84552DAA2266B792" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWF3</accession>
    <name>U4LWF3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Alkaline ceramidase YPC1 acc. no. P38298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWF3"/>
    <dbReference type="STRING" id="1076935.U4LWF3"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WACEYLI"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
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                <person name="Marcet-Houben M."/>
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    <sequence length="314" mass="35104" checksum="B8A0E94A335701F7" modified="2013-12-11" version="1">MLQPPSTRANKFLVLEFLSPYLAAPKKLKHLKKKIKSASKSKRKRSPRVPATPNPPALPASDQPSPPEPEALEYPGLDELGFHAPDQFGLPPYTARDQLEPRIPLPAQSDLSKQEPNQPTSSPLPALDQQDPPSLAPSEPASEPPSTPQIVPGQLMAEFKIFPHDGNPLDASGICQKSSWDDNDDVGVTVNLGLVLQKTKKKRTSMIGVGWLGQKKEKEKKGKREKEEKGKKLKGKRKETVKEEEEEEEKRDDKGKGKGREEAEEEDKKGKGKKTEDKEKENGKGKQMEEEMEEDSEEEEKGKHRGEEEEEDEE</sequence>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW28</accession>
    <name>U4KW28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW28"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="3987" checksum="E23F26BCC89BA7B7" modified="2013-12-11" version="1">MQCSGNSRVRRAIIRSRERKQARGLKIAPGMPMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW55</accession>
    <name>U4KW55_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein transport protein SEC24 acc. no. P0CR40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935275">
        <property type="protein sequence ID" value="CCX05898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW55"/>
    <dbReference type="eggNOG" id="ENOG502S4HG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YYVQLAT"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="494" mass="47689" checksum="FDABAC90A38C2ED1" modified="2013-12-11" version="1">MSSHQQPAPPQPTGSPNASGPNKAPPPLPHGWIAQWDPQSQNYYYVQPSTGTIQWQVPTKSADDSRPGTPASSNPPYQPSVYQPATPHYDSNQMSNNNNQNTGSPEQGTRGGLGSLAGGIANNFLSGGGKKPHGGSSSSSGLVGSLASGLLGGGKQGKHGSSGSHGSSGGLLGTAAGLAGGLLNSGKKPSSSGGHGGSSGHGSSGSSGGLTGSLGGLIGGVLGGSAASKFTGGHGSGSNNNGHGSSGGYPGAGASSHSNPPYGGSNNSYSGAPPPASYGGSGYGGSNPSTPSYGAPPQQQQYGAPPQYGAPPQQYGAPPQQYGGPPQQQYGAPQQGYTGQYGAQSPGYPPQQTGQYGTPQGGYPPSSGPGGPNQYGAPPQSYQGGPGTPGGYTPSSGPGGPGTYPPTSGPGGPPYPTNNGPSGPGGYPSTSGPGGPGGYNPTNGPGGPGGYTPTSGPPSGYSPAPGANAGYQGTPPPMQYQPPGYAAPPNHQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX09</accession>
    <name>U4KX09_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX09"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6610" checksum="6DF4FA8F9CA1FE51" modified="2013-12-11" version="1">MISRWKAEIPGSSSARLPWHPGARPNAESTALKPRQLSYSTDGFAKCLISHIANISNQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY13</accession>
    <name>U4KY13_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935289">
        <property type="protein sequence ID" value="CCX06435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY13"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="19878" checksum="33B02D0C3C82E603" modified="2013-12-11" version="1">MNSHLGNIPSRPTGPKNLCGQWYLDSRVTRREWLKMLRDRIMIFDFISGNKLQDREDRESRNKVAGKIENELYYMSVLESKQKQVQIIEWQAQDNEGMYEWALHKIHDQDRLERAACNGINHEEDFDTWLDKLEFQVSMNQDKLFIPEIPDKYNEFVALIDPHFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY81</accession>
    <name>U4KY81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Pumilio domain-containing protein P35G2.14 acc. no. Q9P789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY81"/>
    <dbReference type="STRING" id="1076935.U4KY81"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MWEISQG"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="461"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="610"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="674"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="747"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="955"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="976"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1186" mass="127291" checksum="301D728A945F7E4A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ08</accession>
    <name>U4KZ08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Mannosyl phosphorylinositol ceramide synthase SUR1 acc. no. P33300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ08"/>
    <dbReference type="STRING" id="1076935.U4KZ08"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRHSWSF"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="328" mass="38518" checksum="7820AC354EF7B076" modified="2013-12-11" version="1">MRRGVALFLLINFLILGYILNSVFTLITLLFEDCKADAILSSEIPAPGSELIGKGPQYIPRIIHQTWANESIPEKWQKAQKSCLDLHGDYEYKLWTNEKSRDFIEKEYPWFLETYDNYPYPIMRADAIRYFILSHYGGIYLDLDDGCERRLDPLLSYHAWLRKTVPTGISNDAMGSVPQHPFFLKVISELQRYNRNWQIPYVTVMYNTGPLFLSVVWKQYIKTVSSEEQRVRILMPDEYGNKPWKFFGVYKGSSWHRDDAKAIFWMGQHWGWVTFAGFALGLSGYAAIYLIYRRLHLKRSGEYRTGAAGTAWSFWPWRSGYRRVKHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ12</accession>
    <name>U4KZ12_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ12"/>
    <dbReference type="STRING" id="1076935.U4KZ12"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="375" mass="41611" checksum="E6C8ED231E5C33B6" modified="2013-12-11" version="1">MEDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAISRVDMAGRDLTDYLMKILAERGYTFNTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHATTFTSIMKCDVDVRKDLYGNIVMSGGTTMYPGIADRMQKEITSLAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZA4</accession>
    <name>U4KZA4_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_04207</name>
        <name evidence="2" type="ORF">PCON_10928</name>
    </gene>
    <organism evidence="1 3">
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <strain evidence="1">CBS100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935224">
        <property type="protein sequence ID" value="CCX04994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZA4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="9004" checksum="6EE443A87733724B" modified="2013-12-11" version="1">MMRRLYEVALKRDPVKTESTNKGSLGYFVGERSICKADWKVHVYSTYEAKICNIISEDNLVRPVYPINSVTGTSCRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0A1</accession>
    <name>U4L0A1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX07979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0A1"/>
    <dbReference type="OrthoDB" id="10566068at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32709" checksum="E459BEBE910E69EA" modified="2013-12-11" version="1">MPCFLTHTTHLPCLHVTPSPQHSCLYPSRCVSVRELFFTSQNLCSSCLSAPATSSSSSLGDWSDWSRTLGSYTRCQGSGSVIGESGAKWTSGTGWGSGCGVGWRSVAGNASMPMGNRPPLEMLGCHAEGRGVYEIDVSEKGKRRVLQQQAQAQQARRAGKAGQDRQAGRAGQAAEGKQQGWGGWFKSILSASTNVQATPRSMPSSTTRNSSTPRSYNTKLATSIEADDWEVEEAELAESRRGNSSWTNEKWLESWVELEIPVVDLDLKEDLDLDLEEDLEEDLEGDAEMEMVEREVECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0M5</accession>
    <name>U4L0M5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to N-acetyltransferase eso1 acc. no. O42917</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0M5"/>
    <dbReference type="STRING" id="1076935.U4L0M5"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWPCSNL"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="10">
        <location>
            <begin position="40"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="11">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="573"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX05589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="626" mass="69710" checksum="1C16C08A59B1EC93" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1X2</accession>
    <name>U4L1X2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to MAP-homologous protein 1 acc. no. P43638</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935478">
        <property type="protein sequence ID" value="CCX09651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L1X2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949">
        <property type="entry name" value="GASTRIC MUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949:SF2">
        <property type="entry name" value="OS05G0480600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1292" mass="138974" checksum="EC267EBCE0D1FB3A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L295</accession>
    <name>U4L295_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935540">
        <property type="protein sequence ID" value="CCX10396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="29" mass="3284" checksum="AE95000B63E3DCA4" modified="2013-12-11" version="1">MGFASFWSPLVLWMSFAYGTTATTRPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2J0</accession>
    <name>U4L2J0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to LON peptidase N-terminal domain and RING finger protein 1 acc. no. Q17RB8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935468">
        <property type="protein sequence ID" value="CCX09509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L2J0"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="236" mass="27073" checksum="331E4F66199BC791" modified="2013-12-11" version="1">MSRLIPSQLAARADAAIAEAEELSRTQSINTPIFVCAASFPDMPTPLFIFEPRYRLMIERAWHGNRLFGMVLPNLGTDEGLGNVHFNRHGTMLYIETLHLQEDGRSHLFCRGTSRFIINEWGWKDEYLVASTKRISDIPPSMEENMEMRRVAAGAPSTRALMEEAFEFAQYWAVGLHPGAMAAYGEPPRNERTLAYWLAVILPIARRNQYQMIKAQSVRERLEIAVGWTRTMERNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L314</accession>
    <name>U4L314_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="HF935204">
        <property type="protein sequence ID" value="CCX04430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L314"/>
    <dbReference type="STRING" id="1076935.U4L314"/>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRAAYHN"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
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        <location>
            <begin position="13"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
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            <end position="219"/>
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        <ligand>
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        </ligand>
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            <begin position="234"/>
            <end position="243"/>
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        <ligand>
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        <ligand>
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        </ligand>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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</entry>
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            <begin position="78"/>
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        </location>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="104" mass="11122" checksum="F2B4FF6D56E4D2B5" modified="2013-12-11" version="1">MPSTAVPENSPTLGDVTDTIINKIKPTLKGIAESRAVSYATNWVENTITAENIDAVKNLVPTITVETLVPDVETVKNLVPTAYGYVKNLIWGGEKQGKGGPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5Y2</accession>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="9301" checksum="388AEDB3ACF562AE" modified="2013-12-11" version="1">MIRPLQLWRRLRHKQPAQTPHPPVGSRGQARSSHSELRTNPTNPTNLGRIYQANDRMYPTFAYICVYPPRKYRNNSNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L710</accession>
    <name>U4L710_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L710"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="181" mass="21003" checksum="A48E8889A7B4183D" modified="2013-12-11" version="1">MSELRKPTDATVDYNFYSCENADLRDGTFETGRLEPIAVDDNDTGDDYTMPDFPSPAQLRRERHSAMAKVYRVPRQRRSKRSSHLRDCDAKMDWEQENGSHKRTRIKRKSKRESKREKHKEKMAELKENRHRGREEYISKSFQQPPPWKDVSGLQPTSSLSCDTSPEISQQNLDATSAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L711</accession>
    <name>U4L711_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L711"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="302" mass="33824" checksum="B4CCFC9833E057C7" modified="2013-12-11" version="1">MPSFTPINVPSLKRQRVDSSTPRLPKAPPLQRSNTLAPIREASIKPNRLPSIRDLLRTLNIDSLSATPPRSTEPKHHNPAGHYFSPHHPHHPQPTAALSPSSTPIGLPAKTRAQVTAHIVATEAPAAPKCPKRGTATALGTKIVKLPAVRNQPIRCPSHQVHRVDPRAARQYRYPPSDKAATAKTTYILMSENPVLKSSHSRKRISGGLSKPKPAIREWCVERTIPFERRDMGRRHSVVYGAEVAMKGMARGATQVRIQRAERREAERQAVEMLTSMKHRRGKAWCVGGEVLERRWREKWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7A1</accession>
    <name>U4L7A1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to N-acetyltransferase ats1 acc. no. P79081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935701">
        <property type="protein sequence ID" value="CCX12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7A1"/>
    <dbReference type="STRING" id="1076935.U4L7A1"/>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IAVKCRC"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19379" checksum="6E065E90C430C776" modified="2013-12-11" version="1">MAPVVILRKAEAADASLILELIHALAAYEREPPSTVQATVETLTATLFPSSGTPYARVILAFTPENEPAGMALYFNNYSTWRAAPGVYLEDLFVYEKFRNRGYGKALLAALAQETQRIGGKRLEWSVLKWNEPSIKFYESIGAQNLGLEWQVMRVTDEALVKLAERGPEVKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7F3</accession>
    <name>U4L7F3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935426">
        <property type="protein sequence ID" value="CCX08629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7F3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="11609" checksum="688EF36AC96B0634" modified="2013-12-11" version="1">MTVSSPDVHLARQVRLHLVVVGYQSILAIDYSTVSGYQLTSSSLMITVPSPGPRRGLKSHLLSIGYQCICWLESYKTVPEASDPQAPRKLPKPPNGPPNASSEGPPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7H8</accession>
    <name>U4L7H8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7H8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12720" checksum="1D7994388131ED02" modified="2013-12-11" version="1">MSNNISITQSISGTGAIRIAGASQTTHRVFALDVCSGRLGSEILNTAVWIHKGQFDGLRKMLKLITKPVPQQADEFSTIPNQLDQREILHITMSLSPLLLLEELKQPTSNRCQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L864</accession>
    <name>U4L864_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L864"/>
    <dbReference type="STRING" id="1076935.U4L864"/>
    <dbReference type="eggNOG" id="ENOG502SD2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFRECFF"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="946"/>
        </location>
    </feature>
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        <location>
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            <end position="109"/>
        </location>
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            <begin position="352"/>
            <end position="376"/>
        </location>
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            <begin position="411"/>
            <end position="648"/>
        </location>
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        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
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            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="980" mass="109284" checksum="E987B1B273114FC1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L895</accession>
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        </submittedName>
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        <name evidence="2" type="ORF">PCON_13934</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14341.1"/>
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    </dbReference>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="196" mass="22077" checksum="1B0135AFD77B1305" modified="2013-12-11" version="1">MVLIKADTDTSKPEIGQNDADAGSTTSSNPSEQETALAKPLPDAPLRRLHSTVVPSIALTKPQPSRLPGESKDYSILSRPLADDDKKKIEKKTFYLEYTKPRLIENALPEIAIPFPDDAHLNDNSLIDYKAAVESHRIKLQQRQIDHEYAFEERFKSEDWYQGTSSKTKTAKRGPMDMEWRRSPGIPQSLQIVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8B7</accession>
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        <submittedName>
            <fullName evidence="4">Similar to Choline dehydrogenase acc. no. Q6LGH5</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <name>FAD</name>
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        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <position position="91"/>
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        <location>
            <position position="226"/>
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        <ligand>
            <name>FAD</name>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX13087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="531" mass="58446" checksum="E2E64076016D39D8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8R9</accession>
    <name>U4L8R9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to THP3 homolog C2A9.11c acc. no. Q1MTP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935495">
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    <dbReference type="STRING" id="1076935.U4L8R9"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="305"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="491" mass="55568" checksum="182CB34D7470C72F" modified="2013-12-11" version="1">MAAPPPWRSGAASNGYTSVEARRSFAAPRTVGSSTTTTTAAATSPTGGGAAKTTFPDPLKQYVARTFENIAEADKKDVEIELKRIITDAFNEKVVWSINWDEMPLPQVILQKRRNSQGQQVTNSDKSPPLKSFGKFSISDTKKRKSAGDDTTITNKYTERSDKKARQQSPYTGFSDKLSQRDKEKRATRFAKELRAVTPPIERNINSTTHMDIDVAQPLVGRCMTLEKRYLRLTSAPDPDNVRPLHVLEKTLELLKKKWREEQNYAYICDQFKSLRQDLTVQHIKTEFTVSVYEIHARIALEKGDLGEYNQCQSQLANLYAEGFTGQEEEFKAYRILYLLHTCNRADMNELLAILTPTDKQHPNIQHSLQVRSALAAGNYHKFFRLYLDAPSMGGYLMDSFAGRERIAALACICRAYRPDIDIRFLTEELGFESDKECVEFLCDHGAEELIQQKVLDNGTTSIRLNTQKASPIFEQAKQNAFKKVDIKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8T0</accession>
    <name>U4L8T0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
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                <person name="Kumar A."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX15416.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L938</accession>
    <name>U4L938_PYROM</name>
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        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">PCON_06226</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
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        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
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    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
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        <property type="reaction ID" value="UER00653"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
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        <property type="entry name" value="Dihydroorotase_CS"/>
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        <property type="entry name" value="DNase_TatD-rel_CS"/>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
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    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
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    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="85"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX06639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="502" mass="54197" checksum="ECA70CA3AB28D5AB" modified="2013-12-11" version="1">MAPLLDTPIVSLTTLPVQPDSPITPLEETPIVLVSNNVILPNRIQTAGTIVISPTTGKIINVLPEIVPAERFPPGTEYTDYSPKFLMPGLVDAHVHLNEPGWRTEWEGFDTGTKAAAFGGVTTVIDMPLNAIPPTTTIENFNEKLKAADNACWVDVGFYGGVIPGNEEELLPLVKAGVRGFKCFLIESGVDEFPCVTSEDVAKAMEKLKDSSTVLMFHAEMIPPIAASVGDAVLHSEPPAAPTGPLNAYQTFLESRPQSFETYAIEQILALAPYAPDLQLHVVHLSAGEGVDLVKKAHANGIKLSAETCFHYLTLAAEDIEDGDTRHKCCPPIREGSNREFLWDALKDGTITTVVSDHSPCTPDLKMLPNNGGSGDFFEAWGGVSTVGLGLSVLYTEGRKRGVDLPTMAEWTSYNTAKQVGLLGQKGALADGYDADICVFDPEATFTVTTADMHFKNKVTPYEGKELHGRVCETWLRGKRIYSAETGFEKGGPMGELLLAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L992</accession>
    <name>U4L992_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HF936202">
        <property type="protein sequence ID" value="CCX15567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L992"/>
    <dbReference type="STRING" id="1076935.U4L992"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSTIDFI"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="184"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="420"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX15567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="577" mass="64781" checksum="D21B47954C3B3068" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9A4</accession>
    <name>U4L9A4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_13254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9A4"/>
    <dbReference type="STRING" id="1076935.U4L9A4"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001105">
        <property type="entry name" value="WD40-repeat-containing domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="355"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="445" mass="50760" checksum="5E3F750B0541BBDE" modified="2013-12-11" version="1">MKIKALSRSAETYNPLGTTAVVQPRNLNPEMHPFEKAREYTRALTAVKMERMFAKPFIAQLGNGHIDGVYSFAKDLKRLDTVASGSGDGEVKIWDLADRKEIISVKAHEGIVKGLCFTSVGGSRRLLSCATDKTVKLWDPELNRDGNNAPVATYFGEQGFNAVSHHRNDRNFATASGVVDIWDWDRQKPITTLQWGADTINTVKFNQSETSVLASAGGDRTLILYDLRTSSPLAKLVTTLRNNQICWNPMEPFNFATANEDHNVYIFDMRKMNRALNVLKDHVAAVMDVDYSPTGEELVTGSYDRTVRIFKAREGHSRDVYHTKRMQRVFSVAFTTDTRYVLSGSDDGNVRLWRAEASARSHVRSAKERTKLEYDAALKERYKHLPEIKRIARHRHVPQPIKKAGEIKKEEEASIKRKEENRRRHSRKKDMRRIPQREAMIVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9H5</accession>
    <name>U4L9H5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UPF0400 protein C337.03 acc. no. O74814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9H5"/>
    <dbReference type="STRING" id="1076935.U4L9H5"/>
    <dbReference type="eggNOG" id="KOG2669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWMQRLK"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="423" mass="46441" checksum="A16DC2C2E6A68E76" modified="2013-12-11" version="1">MAGSYNDETVRAKLSALNDSQDSIVAVAQWVMFHRRQAKRSTELWFERLKESSPHRKLMLIYLANEIVQQSKVKNRVEFGNAFTVLIVDGAETAYKGCPADIQNRIRRVVEVWRQRSIFKPEVQAEIEQRLDSIDKGKSSGAAKGGLGGGLKLGGSFLGGKASDVPLEIVPLLKTRKEIEEKASSVTISTGSANTEFAKQFDTEHLPSPPVYAARLSTLLKTLDTADIAIKGAIDARKAHIRNIERILEQNKAALAKDEQIAADLAQKKEKAETTKASVEQLILEGMEENNGHGDNAGSSGDKTPDGPRSPEIEALTPPAQIQYEAEPPVSASELHHQHSMAPSAPPHLPEFHAGASELLASLSAPLINGTGLKRTQPEETNMFEGVDEDLMNMFKNEAQQQQQPQKKPKFEPPQDDDDEYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9U5</accession>
    <name>U4L9U5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Stage V sporulation protein AD acc. no. P40869</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936177">
        <property type="protein sequence ID" value="CCX15491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9U5"/>
    <dbReference type="OMA" id="QDTHAGG"/>
    <dbReference type="OrthoDB" id="10536317at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.40">
        <property type="entry name" value="Stage V sporulation protein AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010894">
        <property type="entry name" value="SpoVAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038369">
        <property type="entry name" value="SpoVAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07451">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="24049" checksum="7A06F09E04A3E5CE" modified="2013-12-11" version="1">MESLALAANLVNSGSAKFVLAGTCSHDSGAEKQFRYPTEYGSQKPPTAQYTVTGAGAAIVSMEGDGPVVTSATIGRVIDMGIKDPFNMGAAMAPAAVDTIEAHVRDLGIEPGYYDLIVTGDLAKVGYEIACKLFKKHNFPIEQTEYSDCGMMIYDYETQMVQAGASGCGCSAVVTYGHLLNRMRRGELKRILVVATGALLSPISFQQGESIPCIAHAVSIEAGREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAG7</accession>
    <name>U4LAG7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAG7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3529" checksum="F53FDECBAA43FD87" modified="2013-12-11" version="1">MPFQSISTHPITQHIHPDPDSPLFYFHHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAH3</accession>
    <name>U4LAH3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAH3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="7158" checksum="A1EA06E6597104B0" modified="2013-12-11" version="1">MRAISTDWNDGIPAYTQWLQDMAKQLYDTWSTEMSYNKDDRSLLGASRCQKDSALSTLFANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBC7</accession>
    <name>U4LBC7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936576">
        <property type="protein sequence ID" value="CCX17125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBC7"/>
    <dbReference type="eggNOG" id="ENOG502SY31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEGHRPG"/>
    <dbReference type="OrthoDB" id="5367079at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="141" mass="15080" checksum="44EBA0274B1A8A52" modified="2013-12-11" version="1">MILNLPSTPSEFGSESGPPTPMSCISTIAIKDGHEGHRPGFDGAAERISRLSALSAGGYFDVNKRPDTPSSDADELRKKRMDTAADSPASSVTTESAREQRKEARMIDGMTYDDDVVDTTDRSPMVAGTPVEGMSTVELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBK3</accession>
    <name>U4LBK3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936658">
        <property type="protein sequence ID" value="CCX17459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="92" mass="9967" checksum="981D24C6B1E6BA13" modified="2013-12-11" version="1">MSAPSTPRSSLRIRTDMSSTNSTATSPITPPSTRHHSRSTTFTPREGMQLPATLKMSQYTGEYLAEILSGVAYSRGHGHKRGGLEGVFGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBL0</accession>
    <name>U4LBL0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBL0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4453" checksum="1E55E1969E03883E" modified="2013-12-11" version="1">MEIGFTPCKHRSLIAAPKQTQRQDPAVETMLPNPIPMFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBM8</accession>
    <name>U4LBM8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936674">
        <property type="protein sequence ID" value="CCX17586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBM8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10452" checksum="3B7A7D8D422C329B" modified="2013-12-11" version="1">MESPPVSTDTEMDLTLDNTDSLTPAANPNDPTDPAWLHHDHNSINPIRDSTNNDDTLQHATPDQPTGHDNQPADPVTPFHGHLPIPPLPPCRLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBW2</accession>
    <name>U4LBW2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBW2"/>
    <dbReference type="STRING" id="1076935.U4LBW2"/>
    <dbReference type="eggNOG" id="KOG2346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YNLKPPG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX11755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="271" mass="30320" checksum="5BB6C5CAF93A4CD5" modified="2013-12-11" version="1">MPPPSQPPSRTPSISISSPPPTHSYPVSTTSNHSSRNNSLDIPCDSPRRPPNKRNRSALRQFYGLSASGEVLEELDRKDFTEKEYLDRLLATKSVKELLVGENDLVNDIRGLDGERKALVYDNYSKLIAATDTIRRMRASMEPLTPTTSTLEPAVSHIEGVSRELVAGMKAAGLADSREVVQARAVKWALAAPERIRKLRREGKQERAQEVWERLQGLCDKWGSAKGTEELRRRGEEAVKEELNTETGDGKREEERKKEGEITTKDTNEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC22</accession>
    <name>U4LC22_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC22"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17315" checksum="5D81B9E981003153" modified="2013-12-11" version="1">MCGCEGGGVVEGGISLRGGRSTRLQWRDVQVAGMLTTPNRIRLVLNNSSRCPAVNALRSKGSKGTKKETLGSTSDRPANGCRQIKRHFPGWYNRACERTKGLKPRKQNAFENNEETQKLKTEKHVTSSQSSKKKPALPVANEILFRLCSEENALAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCI3</accession>
    <name>U4LCI3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935394">
        <property type="protein sequence ID" value="CCX08173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCI3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5659" checksum="1EAC60F84119C1FD" modified="2013-12-11" version="1">MKHDKVSLLLTKFRSPGSSTPLTAHVHVHSYIFKPIEAIKFMVSRVIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCT4</accession>
    <name>U4LCT4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936499">
        <property type="protein sequence ID" value="CCX16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCT4"/>
    <dbReference type="STRING" id="1076935.U4LCT4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2432" checksum="4CBAA01B76B6F5B4" modified="2013-12-11" version="1">MFGIQSSLDLLVSHCCPDRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDU8</accession>
    <name>U4LDU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDU8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="151" mass="17667" checksum="DCBD08F74125A039" modified="2013-12-11" version="1">MSHPEFPNAKHPDFITQEDFDRYIRSHHVEMDENPSELMYSHWLQGRSLEEAAGLRGNNALRAMLQRRERQMRQREREMIQIRALVRRAQKRLLRLRSYMAAMEREMGRLDRTRRNAEATLASLEGGQEDAGQGEAEQEEAEQQENSNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEJ8</accession>
    <name>U4LEJ8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_07796</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="HF935395">
        <property type="protein sequence ID" value="CCX29977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LEJ8"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HACSVIR"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="2426"/>
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            <end position="994"/>
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            <end position="2843"/>
        </location>
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            <begin position="769"/>
            <end position="779"/>
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    </feature>
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            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
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            <begin position="970"/>
            <end position="983"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
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            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX29977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2891" mass="325311" checksum="EEBF733C156C09A4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 100304</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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</entry>
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            <taxon>Pezizomycetes</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="12" mass="1561" checksum="434A16358D541B53" modified="2013-12-11" version="1">MSRTKYRNSDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFM8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Kinesin light chain acc. no. P46825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09065</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30698.1"/>
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    <dbReference type="OrthoDB" id="1658288at2759"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="702" mass="79641" checksum="E013456CEFF7001A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFY3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_09201</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHW0"/>
    <dbReference type="eggNOG" id="ENOG502SABV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DKMCKDT"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651384" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="17"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="285" mass="32289" checksum="E3E3C70BC9BBD954" modified="2013-12-11" version="1">MLSYYIFTVLAFVSLALGHSWIDELTVVGVTGNQGVNEKGYPRNYKGHFDDYTSKILDFTAPRPLCMKDQTTPNTNTQQFPPLSAAPGSIIQAQYTENGHITGPEERDNETIPGYSSGLMYWYGWTDPAYQPTMQEVFLWTADGKGGNGKGRLLKDKVPYDNGVCAEANVKPISFQRIPQLYEKLENGTDILDAPLPRVNIPCTTQFQLPEDLAGPTYTVAWVWDYSTKAGHVAADPYARKTNEWYTTCMDIKIKTPEPAPKFRRRHVRDRRHPRGFAGRWTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI04</accession>
    <name>U4LI04_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935546">
        <property type="protein sequence ID" value="CCX31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI04"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5805" checksum="687935F1752ABD68" modified="2013-12-11" version="1">MFSRTFSACLKTLPAYQCGTTSDTAEFTLHPRQVLTNYLREASYGIMLCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI60</accession>
    <name>U4LI60_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI60"/>
    <dbReference type="STRING" id="1076935.U4LI60"/>
    <dbReference type="eggNOG" id="ENOG502S0Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAMTLFN"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="722" mass="81731" checksum="845383A39612002C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIA0</accession>
    <name>U4LIA0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIA0"/>
    <dbReference type="STRING" id="1076935.U4LIA0"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX31307.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5371" checksum="B3856395AB4EEE41" modified="2013-12-11" version="1">MAPLNQISWTLPVVTTLEAFGALDVPNPQLRPNLQSHHQQQAKPVTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIG8</accession>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="13154" checksum="92B4642A225F18FF" modified="2013-12-11" version="1">MSSETPISIPQPASATSKRSSSPVSLTINTTNLQPPISHNRSTSNTLTIGSHDTTISGASTLVPNSPVILTAENKAFRNVEDISARISVLSLRDTATDTAADILPSTYPDRYSLQYCTHAGPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJD8</accession>
    <name>U4LJD8_PYROM</name>
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        <submittedName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LJD8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="501"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1091"/>
        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="879"/>
            <end position="905"/>
        </location>
    </feature>
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            <begin position="1024"/>
            <end position="1084"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="821"/>
            <end position="831"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004267"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1118" mass="126676" checksum="9FDA271A159BB941" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJR7</accession>
    <name>U4LJR7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29625.1"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMK1"/>
    <dbReference type="STRING" id="1076935.U4LMK1"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YIVQENS"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="310"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="658"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX15289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="687" mass="75685" checksum="D7FDE7E2B7C2BE11" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LML4</accession>
    <name>U4LML4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LML4"/>
    <dbReference type="STRING" id="1076935.U4LML4"/>
    <dbReference type="eggNOG" id="ENOG502S1FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GGWLFND"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053881">
        <property type="entry name" value="Utp8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22542">
        <property type="entry name" value="Utp8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="2">
        <location>
            <begin position="57"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Utp8 C-terminal" evidence="3">
        <location>
            <begin position="432"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="946" mass="102872" checksum="FD9EAC2023D13435" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMN9</accession>
    <name>U4LMN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Cyanovirin-N homolog acc. no. Q5MK11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMN9"/>
    <dbReference type="eggNOG" id="ENOG502SE9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSFHNSC"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="12532" checksum="FE044587C9560A3A" modified="2013-12-11" version="1">MSFHISAKEIELKDGHWLKATLKNRNGDWVHSKLDLDQCIGNTDGWFIWGGKNYSHTARNFRLEEGGAKLVAELLTADQRYRELQGIDLHHRIENRDGKLHFLDDSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMP8</accession>
    <name>U4LMP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to LIM domain-containing protein C4F6.12 acc. no. O74398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMP8"/>
    <dbReference type="STRING" id="1076935.U4LMP8"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MVHFEER"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="617"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="678"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX15428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="740" mass="81070" checksum="D61CBAFA3FA7A9ED" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMS0</accession>
    <name>U4LMS0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936058">
        <property type="protein sequence ID" value="CCX33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMS0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="162" mass="18381" checksum="3CFD02E2657F2C52" modified="2013-12-11" version="1">MARQNQRPKHKTRKEKKRESGASSHSPPADSSRAKKRYELEQMLLHPQIEEPAEKGRVVFELQVIRPVIKEPPTAKALALPGKARDPRDVVPKFANSGDQSVTDSRENASSSRSIRIQNLKKELALLNAQIEHQKRFCAILAEKTKSITSMYREISSMLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMT9</accession>
    <name>U4LMT9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_13743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMT9"/>
    <dbReference type="STRING" id="1076935.U4LMT9"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PNHIRIE"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="371" mass="40895" checksum="4DD02534F763CB3C" modified="2013-12-11" version="1">MTSLTRAFSTTCRKAASAAAAATAAKLPTPRVVFSGIQPTGVPHLGNYLGALRNWETLQTEAAPGDKLLFSIVDLHAITIRQDPEQLRRHKRECLASLLAIGLDPKKSIIFEQSSCRQHAELMWILSCGASMGYLSRMTQWKSKIGVGETEDALGKKAGKTLKLGLFSYPVLQAADILVHRATEVPVGEDQSQHLEFTREIASGFAALYKDVFPLPKTVLSPAKRVMSIRNPSVKMSKSDPDATSRILLTDTPEEIQNKFKKAVTDSLGTVTYDLKERPGVSNLIQIYSHMQRRDDFEAVAKEFEGCNMTQLKTRVSECVIEKLGGFRKEYERIMNESDGYLNAIAEEGAKKANESAEGTMLQVKKAMGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMW6</accession>
    <name>U4LMW6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13777</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="174" mass="20014" checksum="E00B8AF68638E255" modified="2013-12-11" version="1">MDATSYTISLRHTLLNSLKSHLQIRFSRPGHREVLYQVSLTKHDHKGIEMTECFWEVYRRQPVAMFMMVKRLGDSGCCKGCEDLAERLNAFMDMHDEHMKNAQEGLPEAAAQLFEDDLTIEDPEDPKGHWSGFWCSLECTIDELLSPAVDNEVPPAYTSLFPANFVACLRIWNF</sequence>
</entry>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="123" mass="13707" checksum="8F29DEA4739AA4CB" modified="2013-12-11" version="1">MSRSSVGNPQTYEAGDMRDSKSTSKTNHDMSYREGKKNSHLDNDSKDQRSIANRMASAEKKGKEHNDDHNDDHKSKDPRDAALKHGNQPSKGAKIDAELQAEDELRLQEKGMKGKDGMPGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN82</accession>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652197" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="15318" checksum="E97B27A2A8BCF214" modified="2013-12-11" version="1">MSALALYFYILTAFAPPGVALELSRAIMNYQHHLYDLFKRNTFRSVLVYHFTFHGKRARLDVYDPAGWEPQEIGFFNLLETNEQAALDQFTNEYKPAPKCQATGAKFTGGAPCNKNNDGECNHKNCRYPHVCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNH4</accession>
    <name>U4LNH4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized transcriptional regulatory protein C3C7.04 acc. no. O14130</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCON_01340</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
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    <dbReference type="OrthoDB" id="424974at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="842" mass="94843" checksum="40444DA0B4959F8B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNN1</accession>
    <name>U4LNN1_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNN1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="22755" checksum="231E9919ED70013C" modified="2013-12-11" version="1">MRCTNLMVQAKDLALPLAASRNRLGVQFQDTFIVSPSRLPEKQSYNCTSAPIEHETSYSWANYCSGPLMPPDNGACGLNHGIPIFVRRLCQWSSLFHGFASLLFLLQIPGVVCAPMPTDSTGGVPNAAAAQNGGFSEPDKWNVSLNAVAVLLTFVTFLTGLPCWNNRKACGFGPSAWENIVRQDSPASGSPQDIYICNGTVSFGHNGNNDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNV5</accession>
    <name>U4LNV5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNV5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="221" mass="26199" checksum="56F64D99558CA858" modified="2013-12-11" version="1">MSLLQKIPKIRPAPRLLVYRPKSIIFFASKNFSSKSHKPHDPTQQQKAFPYHAPPYSCNLLDALDKQLQKYLGSRLYQILVTLCITDGGLVPRDIRPNESAFAFFLDNHKRVIKRIGLRFYLPLIVRFYFYLICNYRLIQKYNMEREEQYLQAVRCAELLRYMKKAKKVKKVKKVKKVKKVKKVEKVEKFEKVEKAEEVEEVEKVENVEKVKKGNNYANKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP50</accession>
    <name>U4LP50_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP50"/>
    <dbReference type="STRING" id="1076935.U4LP50"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WWTAFEV"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="540" mass="58382" checksum="565793483DE7C0EA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPK7</accession>
    <name>U4LPK7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Uncharacterized WD repeat-containing protein C577.09 acc. no. Q9USR0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPK7"/>
    <dbReference type="STRING" id="1076935.U4LPK7"/>
    <dbReference type="eggNOG" id="KOG4283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEIFMFE"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="399" mass="44367" checksum="FC85C83EAB309F85" modified="2013-12-11" version="1">MLNQYLFARELGNPVSRQLEMYENNRLWHCLTRDEHTSFQTKELEKGVNCMDIERQQRRFLLSGQANGSVCMWDLEKSTSTDAGQDVDPDEKFLSPTATVTASKDTHTHSLTSLHYYPIDAGMFLTTAFDRRLLVWDTSTLEPAFSTTFAHAPTSISISPMGHHTLVAVASPGPEVRLVDLASGSSVRSLGTGGTASVRWSERDGWLLMAGSTEGEVSIWDVRMARGCLGMLGERRGRVTRGHEGPVNGITFSEDGRYVVTSGRDKKIKVWDLATGADTLIAYPPLHRPHRIFSSNPILTPQITSDPQLLFVPSIDEVIGFDFLRGDVLVKSRAVTQKHTINALIARPNHCELYFGCSGGEIGIMKAPELRLNEDGEEKEENVLNRIYKSLVQEPITFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ36</accession>
    <name>U4LQ36_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ36"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="50" mass="5907" checksum="3F78A1AB4BA47E75" modified="2013-12-11" version="1">MSLSMPLLSHFHCTVREKMHKVRCNLFHLPNAIYKQNPNQHDGRSGKIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ41</accession>
    <name>U4LQ41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Probable 4-coumarate--CoA ligase 1 acc. no. Q54P77</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ41"/>
    <dbReference type="STRING" id="1076935.U4LQ41"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPINPIY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="402"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="502" mass="55907" checksum="8828943A81562D6C" modified="2013-12-11" version="1">MPVQSKYPPIEVPTVDLWKLMFERKDRPFPDNQGNPNNIDVPPLSLGVIWASGTVTPANPTYTADELTYQLKDSGAKAIATQADFLPLVLEATAKAGIPKDRIILLGDKRAEGFMHWKEIRDDSQATKWRRTKIDSKKDVAFLVYSSGTTGLPKGVMLSHTNIGSDVRMLMAGEGDNLTWQNDSILAFLPFFHIYGLTCLIMHNVYSGKKTVVMDRFEIEKFCKLVQEYRITYSYVVPPVVLLLAKSPVVTKYDLSSLKMLNSGAAPLTSELVQAVWDRIKVPVKQGYGLSETSPVTHTQQWHLWQTTIGSVGYMLPNLTAKYCDEEGNEVPVGQTGELWLKGPTIMLGYLNNPTATKNSITEDGYFKTGDVGHQDKDGNVFITDRVKELIKYKGFQVPPAELEGKLAAHPKIDDAAVIGVYDEALASEVPRAYIVSKPGISREGLAEEIIKYIHDSVAQHKRLRGGVRFIDAIPKSVSGKILRRVLKEQAKKEQLEFKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR10</accession>
    <name>U4LR10_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Transport protein particle subunit trs85-1 acc. no. O94731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR10"/>
    <dbReference type="STRING" id="1076935.U4LR10"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHMENRV"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="659" mass="72544" checksum="6A20B8DE8FB1FA44" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR23</accession>
    <name>U4LR23_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR23"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11349" checksum="85D2176E5D1FCB0E" modified="2013-12-11" version="1">MIIIITNERMAQQTIFRDAAKRRNRKGFIRHGGFLFIAIELSFVGHVLEVPFVGACVHSAIRSGVGFIPQMSISRSPAPPVAIFAPNGVLATTGRRFATHCVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRH1</accession>
    <name>U4LRH1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRH1"/>
    <dbReference type="STRING" id="1076935.U4LRH1"/>
    <dbReference type="eggNOG" id="ENOG502SPZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DCSCCTT"/>
    <dbReference type="OrthoDB" id="5393404at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
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            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
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            <end position="322"/>
        </location>
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            <end position="359"/>
        </location>
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            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="441" mass="48822" checksum="73ECECB0EADE6634" modified="2013-12-11" version="1">MAPIPTNAFGAGPHTISKRASDATAALGSLLRRSLEPRRPSEGNYTRPGKMNGGVLVVFCLIGASLGLLAWWLFIRRSGFIWRKYDWADYKASVLRRPQDRPDDAITVFSDGTARRGGSGSSVGRSVVLGELDTTYQKSYVAGEKPWNARDLPPAPKQPSLISAAYRDVKDSVWGKIRGGDRSENDTVVQRERSLRRERSKRRRRENRDRERGKKHQEEQSPIEMRKQNYRPYDSQQYRNDETETEISTSYVDNQRPAPPLTDMSHSSVQPPPLHRPRGSRSQPTRTQTRGPRVQRPERASTRAGKAPAREPSYRPGDDHANARYHRAHNRNNSQAVSESESDTDTDTDTESSDDDDSTIDQSQLGMAKGNKTYKHTISPEQTFWGNARPVERNGGGAGGTYGGGAPALMPSSSKAPRGYRAASVGSLSSDGSVRSSNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRV0</accession>
    <name>U4LRV0_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Similar to Meiotically up-regulated gene 80 protein acc. no. O14336</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_04180</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34685.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="445" mass="50591" checksum="35C6E84EBA1DCCB8" modified="2013-12-11" version="1">MPCIFQNQSHPLTPPEYQYNSGCFPVSQHPHVLGAQAFPEKGVYEINCDVYGRKMAPSFIRSMPPHQQHVQQHYNNMFTGHSGPPGITHPGNHYGQYAPVGHRGRIRQQPEIPVEQPVVEEKPPTGGVSAHLDYEMEEMTDFVGNVAQQLVLGGYRPTENLLPSYRKFVYQILSSTRLPSSTILLGLAYLKERMDIINRGPATEQNVYRLLTISLLLASKFLDDNTFQNKSWSEVTNIPVTELNALEKEWLRAINWNLHIDPKGDKGFKRYKEMWDSWVRKKAAPSALAPIDTNLRRPSHASIQNYVPQQQQQNHYQVFTPPHSAIMSDRSLPQFQLPPPRAVQQSNEAPVYGWEFHYRGDYSPPSAPETGPTTPEGHFGWSAASVPYSMHTGHQQSNFSRLPPIATYNHNGWHQHHPSAANCYQCRMQSTEQFFNTNYGQPITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRV9</accession>
    <name>U4LRV9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_04587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRV9"/>
    <dbReference type="STRING" id="1076935.U4LRV9"/>
    <dbReference type="eggNOG" id="ENOG502S0G7">
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    </dbReference>
    <dbReference type="OMA" id="AADMMRT"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="517" mass="56938" checksum="A267B1EEFEF9E118" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRZ2</accession>
    <name>U4LRZ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936512">
        <property type="protein sequence ID" value="CCX34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRZ2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="19" mass="2504" checksum="293DD5449A83F09A" modified="2013-12-11" version="1">MRRYSISHHRSYEMRMLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSJ3</accession>
    <name>U4LSJ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Polyadenylate-binding protein 2 acc. no. O14327</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSJ3"/>
    <dbReference type="STRING" id="1076935.U4LSJ3"/>
    <dbReference type="eggNOG" id="KOG4209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YRGRATY"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <end position="45"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19640" checksum="76A9B723A2291738" modified="2013-12-11" version="1">MAKKCSMNLGFKHNFGIKTLLRKFRNLFRRKKEKKERDLKDEKNDTAVPAENCTNVEGAASDASCNAEKRKSRRSSLFFFKDKMRERYEDPYEAYGLQEEPVFDDEDEPSNPAIVRRQTQAKGLEPVRGFGYGFESLVPSMAGKGSQRGLKPPEQKAKRHSFLAIPLPKMF</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kumar A."/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX33295.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="695" mass="77039" checksum="8556B81DFE2AF9BE" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4LU20</accession>
    <name>U4LU20_PYROM</name>
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        </submittedName>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <end position="82"/>
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            <end position="25"/>
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    </feature>
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        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="10890" checksum="95BF45D41C0D58ED" modified="2013-12-11" version="1">MPALQSRPWNIQSPSPKDSDQSSSKLTYFRELSTSSGGSQQWWARQLPRHGKAPTSPPQSSPQGPKGYKGNGASVRVARNPESIRDAVPASILRVRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU33</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="150" mass="17467" checksum="4AB688BCADD9A9E1" modified="2013-12-11" version="1">MTQNTKKSNFLTAHSRRKSRRIAEHWSNVHSPISKETADNIQAVAPLLKVPVIIMTTSDEEVSAVHLTPRCWSLLEKEIEKKREDKIRKNKELSLDCSKPLESYKKEIEELMRVKEELEVSEEIFRLLGDKLATFRVCETKFDPERKNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUF4</accession>
    <name>U4LUF4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUF4"/>
    <dbReference type="STRING" id="1076935.U4LUF4"/>
    <dbReference type="eggNOG" id="ENOG502SIX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANDNEGM"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651680" evidence="4">
        <location>
            <begin position="20"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="696" mass="76718" checksum="B5DD7EB55425B157" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUP6</accession>
    <name>U4LUP6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative glutamine amidotransferase-like protein C13C5.04 acc. no. Q09686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935652">
        <property type="protein sequence ID" value="CCX31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUP6"/>
    <dbReference type="STRING" id="1076935.U4LUP6"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="294" mass="32574" checksum="D6FFB7D81681C205" modified="2013-12-11" version="1">MAPLRIAILEADRPLPETTAKYGSYGGVFSSLLHKAASSTAEPSNLRISSLDTEGSTKGSTGTPASFSSEETYFSQPSTPPELELDIKKYDISYERNFPKSLDEIDAILITGSKHNAYDDTPWIVELVEYVQKVLFEQTRVKVLGICFGHQIIARALGVEVQRSPNWEASVMPIKLSEDGKALFGVEELRIFQMHRDVVTSIPSVSPFPDNASTHILGSSDRCDIQGMYSPGHFISVQGHPEFTPDIVTELLTTRKKAGVFTEEEYNDMMGRVKNEHDGVKIARRMLKFVGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUU2</accession>
    <name>U4LUU2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUU2"/>
    <dbReference type="STRING" id="1076935.U4LUU2"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="314" mass="33606" checksum="9C8493BCF5548641" modified="2013-12-11" version="1">MGVKANKQEYFEKLKSYLEDYKSIFIVTVDNVSSQQMHEIRKALRGRGVVLMGKNTMVRRAVRILMAEFPEYERLIPHIKGNVGFVFTNEDLNEIREVILSNKIAAPARAGAIAPADVFVPAGNTGMEPGKTAFFQALGVPTKIARGTIEITTDLKLVEAGGKVGPSEATLLNMLNISPFTYGMGISQIYDDGQCFAPSVLDISEDDLLKTFLGAVTQIAAISLAASYPTLPSVVHSIVNSYKKVLAVALATEISWEAIEQLKDRIANPDAYASAAPVAAASSDAPAAAAAAAAEEKDEDEESEEDGGFGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWY1</accession>
    <name>U4LWY1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Meiotic expression up-regulated protein 6 acc. no. O94356</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWY1"/>
    <dbReference type="STRING" id="1076935.U4LWY1"/>
    <dbReference type="eggNOG" id="ENOG502S2JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAAHTGK"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotic expression up-regulated protein 6 PH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="612" mass="65075" checksum="D5F8C916B0861F80" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU19</accession>
    <name>U4KU19_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ubiquitin domain-containing protein DSK2 acc. no. P48510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU19"/>
    <dbReference type="STRING" id="1076935.U4KU19"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="375"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="419" mass="42457" checksum="725E8DCAD9EA1D37" modified="2013-12-11" version="1">MADSTAPAETPVDTPEDGIQFIVKQQENKYSLTLPLTTTIADVKAKIAEHCPIPAGSQRLIYSGRVMKDEETLATYSVKAGNTIHLVRAATSSQAAAASSATTGTPPAIPRLSTSTGTGIASQLTGAQYTGVPLPSTSMFGPDGGMNPPDPETFAAALENPMFQSHISEMLRNPDMLDFIIRSNPMLQALGPQAREMMQSDAFRRMMTDPNMMRQATQMRGASTGASFPAPGATDNTPAEAAATPQSGAAAAPGADPAANPFASLFGGAGSPFGSAGNPFAGAAPGGASPFGSFPQPSPQELARAMEALGMPAPGGAGAGGTAALQQMLQAMGMPPPAGGEGAGAGAGGAAANPFAGLFSGGMPPFSQAPADNRPPEERYAEQLRQLNDMGFFDFDANVAALRRSGGSVQGAINQLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUK3</accession>
    <name>U4KUK3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TBC1 domain family member 5 acc. no. Q92609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUK3"/>
    <dbReference type="STRING" id="1076935.U4KUK3"/>
    <dbReference type="eggNOG" id="KOG1091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SPWQTLR"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
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        <location>
            <begin position="462"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="531" mass="60820" checksum="B8298F181D463B35" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUL7</accession>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="23" mass="2377" checksum="31021ECD82D8735A" modified="2013-12-11" version="1">MGLGGETDGAKEDVINWQGKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUZ2</accession>
    <name>U4KUZ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="15" mass="1740" checksum="48FA8F2A1C1EDE8A" modified="2013-12-11" version="1">MDHTVLEKSVKNHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV22</accession>
    <name>U4KV22_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX05002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4KV22"/>
    <dbReference type="eggNOG" id="ENOG502QV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KECRSSM"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="224"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="538" mass="58004" checksum="817134F0360C6688" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVE9</accession>
    <name>U4KVE9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVE9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9388" checksum="64ECBF72D18C2A34" modified="2013-12-11" version="1">MSRQLWLPSTYAQCTLLRIGSLKSQCLHPLPMRPQTSMMITRSSVHQSRDYGHRCGRRVELNKVQRVFRASLRAHSLGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVG9</accession>
    <name>U4KVG9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="9034" checksum="5B4494CB1E4E32E3" modified="2013-12-11" version="1">MSSTADGNPLSYLLSVRNRKTLRDLFIELTMKEQACKPLNNVQEGIRHLVQYVNEEKRVIGFVFWKLSGDNFAKVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVV3</accession>
    <name>U4KVV3_PYROM</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17085" checksum="0C397E25F1A78C92" modified="2013-12-11" version="1">MNKEGILMHTVLYAASIDGMPGRGCLEIRTFDVADDFDSFSRHSISRHVTDDLHPSSNLRSRQTSDLVKLAEDRGTLDDVHLRDYPALSSFVQLWIFCQASSSSGAAGITAGQRHTETRLKKGEKEAPSISDLKFVLPHAEPPFSALPSGSLAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWV5</accession>
    <name>U4KWV5_PYROM</name>
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        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PCON_06024</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 100304</strain>
            <tissue evidence="21">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
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        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="HF935289">
        <property type="protein sequence ID" value="CCX06437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWV5"/>
    <dbReference type="STRING" id="1076935.U4KWV5"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="64"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="310"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
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            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="592"/>
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        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCX06437.1"/>
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    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="666" mass="74457" checksum="A618DFB7FC0AF0F2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWZ0</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">PCON_05803</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWZ0"/>
    <dbReference type="STRING" id="1076935.U4KWZ0"/>
    <dbReference type="eggNOG" id="ENOG502S4G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHANFVE"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="17216" checksum="FBF883C36E2F0C41" modified="2013-12-11" version="1">MSASRSFDFTPTGSSIAGALGLKLAPTTAIFALPFSLYLLLLSGRVVSQRQKTGITLGTNASINTETDPLHKAIRAHANYLENVPVAMMLSLVAEINGGSRRCLAWAGAILFALRVANVEFGLRAKDSKGIGRLIGYFGTNAWLAGMAGYCVLLTRDYWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY38</accession>
    <name>U4KY38_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY38"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7523" checksum="D04B5602E0CC5A16" modified="2013-12-11" version="1">MFIIIDYLDIVKPTLQAMTLLYSRAMYTIDVQPSTTETAESSRTSPGFRVLVPGHLVVKRPPPSFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYI4</accession>
    <name>U4KYI4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYI4"/>
    <dbReference type="STRING" id="1076935.U4KYI4"/>
    <dbReference type="eggNOG" id="KOG4336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="8">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="25471" checksum="B92B211C9A085558" modified="2013-12-11" version="1">MLQTVGLFAIAQRRTKPTVLDFEEMLRQNHISLNGLEDEMQRMPSKATVDSLPPPSPPPLPEPDLSELLGAELDGSRDNRCQIYDHLPPFPSRHTYQETPVFSERPTDPRMIREKATAESRLAEQALRKLLAVSATKKDATKETDQRLGKKRKDRHERWNKAFEGLDKGRKEVNGYSDGGGLNGMRNELATTNSAKKQDEDGYLEVVVNADSQFWRKSKGTLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYM2</accession>
    <name>U4KYM2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Arginine metabolism regulation protein II acc. no. P05085</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935308">
        <property type="protein sequence ID" value="CCX06690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYM2"/>
    <dbReference type="STRING" id="1076935.U4KYM2"/>
    <dbReference type="eggNOG" id="ENOG502QPY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TAQAYRW"/>
    <dbReference type="OrthoDB" id="3886144at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
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</entry>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L078"/>
    <dbReference type="OrthoDB" id="10489462at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="178" mass="19845" checksum="CFBB3C211804CF73" modified="2013-12-11" version="1">MFSTLTDLFVTSPPRNFCCIVRPDGQSTQSTTQSRVANAPNTKSKNGRSHKKSRVRGPFAIEKVNIDDVSERPIFRPARKMERAVILEVNEDDESSTKPTAGSNPNGPAVQITGLRQGHRRDESMKSGLSFSATVRKSKHSRQMSCDSITSVLGEEMVHWYVRAIWLLEGDGQNEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0A7</accession>
    <name>U4L0A7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX07989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0A7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651206" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11119" checksum="8375C60BBF32B78E" modified="2013-12-11" version="1">MQLPTLVILAFSAIAIAAPAENKAQTPAQSTDTCYWMAAGNKEAKGNIIKGVIGCCWQGAVCKAVTPGQQCNPKWTTICCPKKGGVTLKGLKDGICRDKNFTRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0J2</accession>
    <name>U4L0J2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935364">
        <property type="protein sequence ID" value="CCX07713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0J2"/>
    <dbReference type="STRING" id="1076935.U4L0J2"/>
    <dbReference type="eggNOG" id="KOG3083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="281" mass="30901" checksum="33B50C0DEB2249AD" modified="2013-12-11" version="1">MAASRGLDFLSKLAVPAAAAIGLAQASIYDVKGGNRAVIFDRLSGVKETVVNEGTHFLVPWLQRAIVYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPDVKNLPKIYQNLGQDYDERVLPSIGNEVLKAIVARFDAAELITQREQVSNLIRSELLKRAQEFNIMLEDVSITHMTFGREFTRAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESAETISRAVDKVGDGLIQIRRIEAAKEIAQTLAANPNVSYLPGGARGDGNGGGSNILLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0K9</accession>
    <name>U4L0K9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to DNA repair protein RAD5 acc. no. Q6C2R8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935429">
        <property type="protein sequence ID" value="CCX08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L0K9"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SMIPYIT"/>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
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            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
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            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8175" checksum="1D5626E37078C338" modified="2013-12-11" version="1">MLVRSYPDGTGNSATRARADGVASLRNQGAGTRSKEEAHGAGYRQGGPPRGPVDAKIRKPQACRDGRDRSETNTAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3D9</accession>
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        <submittedName>
            <fullName evidence="8">Similar to PARP-type zinc finger-containing protein C2A9.07c acc. no. Q9Y7K9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02752</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="OrthoDB" id="429950at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="579" mass="61064" checksum="8A271A9B3B6C87C9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Z2</accession>
    <name>U4L3Z2_PYROM</name>
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        <submittedName>
            <fullName evidence="6">Similar to 60S ribosomal protein L24 acc. no. Q7SDU2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4L3Z2"/>
    <dbReference type="eggNOG" id="KOG1722">
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    </dbReference>
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    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17600" checksum="751005147F199EEB" modified="2013-12-11" version="1">MKVELDSFSGRKIYPSKGKVFVRGDSKVFRFVNGKSESLFLQRKNPRRIAWTVLFRRQHKKGVSEEVAKKRTRRTVKAQRAIVGLSLDVIKEKRSLRPEARQAARAQAIKEGKEKKAEAESKKKAEKAKNAAGAARGQKVSKQGAKGSAPKVQARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L434</accession>
    <name>U4L434_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Anaphase-promoting complex subunit cut9 acc. no. P41889</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L434"/>
    <dbReference type="STRING" id="1076935.U4L434"/>
    <dbReference type="eggNOG" id="KOG1173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DPFHNNA"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX10494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="625" mass="69743" checksum="AFB87A54A0BD0DD3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4B9</accession>
    <name>U4L4B9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ankyrin repeat-containing protein, putative [Penicillium marneffei ATCC 18224] acc. no. XP_002144344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935605">
        <property type="protein sequence ID" value="CCX11324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4B9"/>
    <dbReference type="STRING" id="1076935.U4L4B9"/>
    <dbReference type="OrthoDB" id="2146628at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="24178" checksum="566A4E325C15A518" modified="2013-12-11" version="1">MASYQFLDFRYSDAMDNEVLENPSYGDNITLDEACQLLREALRKFDLVYLCLDALDECQEHRTPFLSSLKDLFKDFGLSRCLKLFLTGRPQVDQYVNMHITGPFLFSMTLSANKDDMLTYIKYQIEHDDSGIIMGADFMNEIVETNFYGRSNAVAYSRFLLHALQIQHVLEQLTIRSWQEALKAMPKMLDQAFEVTIQRIQNQSVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Q5</accession>
    <name>U4L4Q5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Probable T-complex protein 1 subunit theta acc. no. P78921</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935568">
        <property type="protein sequence ID" value="CCX10845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Q5"/>
    <dbReference type="STRING" id="1076935.U4L4Q5"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="547" mass="58949" checksum="8DEDC3878695F608" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5S1</accession>
    <name>U4L5S1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Pantothenate transporter liz1 acc. no. O43000</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_04977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5S1"/>
    <dbReference type="STRING" id="1076935.U4L5S1"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYANNAW"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="66"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX05390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="503" mass="56484" checksum="EF4F4CF58F5F6956" modified="2013-12-11" version="1">MNQEDEADEDTALMMHYRQLHGDEGNNSSKGDADVNIDIGTPGEDIETEEEKREEKRFLRRLDCILITYVWISYCIKQIDASNYKTAYVSGMKEDLSLHGNELNYIDSLFRIGYAISIIPSSLLLSTYRPSLLLPSLELIWGLTTALMSLATSPTLIYISRLIIGLCEASSYPGTITILMNWYTPSELSTRMALFGTSYPAANIFVGSMQAALWKGLHGTGGMAGWRWLFLLNGVMTIVVALAGYAVIPDSPMDTRAWWIGPRGREISKRRMSRAGKVVGRSGAILGFREWGRLARRLLGEWRIWAFGSAYAAWSWGQNANAWYPLYLKWCKLQDGSPRFTVEQVNLIPIPAFLLHGAAMLVFSYLSDKKQQRGRWVLAQLIPHLIGCLILAVWPPSFWAQMMAIHLLFISNAAGPIILAWMADETGRAPEERTVMVAVMVTVVYAVDCWANLLLWPAKEAPRYRLGYWAAAGWTLVSMFMAGWVKYKVSGGGPVAWVRGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L623</accession>
    <name>U4L623_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L623"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="4123" checksum="715A4BBB5B1E53C1" modified="2013-12-11" version="1">MKIISIYLLPQHTTFQLHAAVTQVRRTIRNCIVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L683</accession>
    <name>U4L683_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Phenylalanine ammonia-lyase acc. no. O93967</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_05122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935259">
        <property type="protein sequence ID" value="CCX05535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L683"/>
    <dbReference type="SMR" id="U4L683"/>
    <dbReference type="STRING" id="1076935.U4L683"/>
    <dbReference type="eggNOG" id="KOG0222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GNFHGDY"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="737" mass="79842" checksum="36D71921A39ED939" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6D2</accession>
    <name>U4L6D2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Inositol-1,4,5-trisphosphate 5-phosphatase 2 acc. no. Q9USQ6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935732">
        <property type="protein sequence ID" value="CCX12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6D2"/>
    <dbReference type="STRING" id="1076935.U4L6D2"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKPDNHI"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651157" evidence="2">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="354" mass="39025" checksum="5353AC80D48BC39B" modified="2013-12-11" version="1">MAPTTPLTLFLLTLNCERLVQPELATALPGMLPTPAPSLLLLSLQELAPLSASFIGGTSLDPYVTTVTESVTTATEALYQTAFPLVGFHNLGMTALLVFQNPTAEVANVSWASVGLGVVGLGNKGAVAVRLEVEGRPITAVAAHLAPDEWNSEQRDHMWKKIVKECIFPDGGQVYPRDEGAMFVMGDLNYRTGESRPEQTAEERVDLDTLWEREQLQNRMKKGLTMQGLGEEEVTFPPTYKFVKNGYSKNRWPSWTDRILFLPNDGTKFKKYDAAMDYTGSDHKPVFAVVELDGTLEKNVETPFLVEPGWKSKKEFSRKGEVIVGLLWAYGIPGVLVSFALLMATTLWLAGKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6F3</accession>
    <name>U4L6F3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6F3"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="10789" checksum="34920A530CE07F94" modified="2013-12-11" version="1">MKHPGNGNPQHPSHSAVAAEGVPSIAKPLEPNAKDMRYVPGTANIQGGKRSNNHCAEILIRGSEIYKHKKQSEKEEAAKKEKKTGSSNKRRPGIDVPAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6Y1</accession>
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        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized transcriptional regulatory protein C139.03 acc. no. Q9UTN0</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">PCON_05382</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6Y1"/>
    <dbReference type="STRING" id="1076935.U4L6Y1"/>
    <dbReference type="eggNOG" id="ENOG502RY77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AISMGCH"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="163"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="736" mass="81302" checksum="60EC377FB2D82E79" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L740</accession>
    <name>U4L740_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Brefeldin A resistance protein acc. no. Q09146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_05442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L740"/>
    <dbReference type="STRING" id="1076935.U4L740"/>
    <dbReference type="eggNOG" id="KOG0866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LFKGMRC"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="345"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="501" mass="53472" checksum="D6CAF98D3E8A176C" modified="2013-12-11" version="1">MNGIEDDVRSVSSDNDNERVREKLKKTTIAPHSRPSSRLAGEDEVMDNTTQRSVPTRKRSHDESDGDDEGRTGRDGKQAHERKRSREVRDEDRKRVGSGLERVKTPPTCQEEDEAAEVLAERLASPGRGERKRALKELDDDAEDDKKSKISKTDEEKKKESASGEGEATTKLPENSGFSNTSSASPFASASGTGVNLFGSSSGSSMFANSKFGAMSGSSASPFGTLGGSSGGASPFATPSTTASPFASSSGTATASPFGGFGGGAKPVSSGTFGGGSAFASSPFGSAKPLGSFGSGGGISGLSALKSPVKKPFGAPDSDEEDDEEDDSEDEDEEVRETKPGFGEEEEETLGLQEQEVMTGEEGETTIHKVMGKVFFFDTETKSWKERGRGTLKVNYKSIPDPENQDNKDDQENATDLPPQKKTSARLIMRTEGTYVVILNTPIYEAMNLGKEPTGNSVTLLAMEAGAVVTTTIRVKSQAAAKELWNHIKDLKEEIYPEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7C1</accession>
    <name>U4L7C1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935276">
        <property type="protein sequence ID" value="CCX05905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="14" mass="1358" checksum="80BAE1041BFCFD15" modified="2013-12-11" version="1">MVVGGRSRALAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7F6</accession>
    <name>U4L7F6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Translation initiation factor eIF2B subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_13173</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
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    </reference>
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        <text evidence="11">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cytoplasmic translational initiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
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        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
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        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
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    </dbReference>
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        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 17" id="KW-0396">Initiation factor</keyword>
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    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
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            <begin position="590"/>
            <end position="609"/>
        </location>
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        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
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            <end position="473"/>
        </location>
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            <end position="317"/>
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            <begin position="482"/>
            <end position="530"/>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX13580.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="611" mass="67540" checksum="E36D446AAAE04B32" modified="2013-12-11" version="1"> </sequence>
</entry>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <begin position="491"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06249.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="1178" mass="132144" checksum="D4A063D6EF72083F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8H4</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kumar A."/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX09673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="75" mass="8532" checksum="3799E36D87375A35" modified="2013-12-11" version="1">MITSTLVERYMRSSITRLSIQDFTPVSTSSTTSSLDTKTFDVHAIQKLHLRSRMLQIFGTYSSKSQKGMFVESVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L944</accession>
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        <name type="synonym">Pyronema confluens</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <location>
            <begin position="68"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="102"/>
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        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="23659" checksum="1BF9208F7A654DA6" modified="2013-12-11" version="1">MTLLPTDDNRNPALKNGNPGLTTPLLSSSSSSTKLGASATPFDATSSQNTIDISQPGSDSPPAKKTQIAPIVGGVIGGVFGLSLLIGLLIFFLRRQRRANTHHESAPVLDKSRASSPTSHASPVYSAPPATTTWNPSSDHNLQSGVPLQETYIPNQQHAQQQGVPVLQPPEAPGAPASQIRAGPVELHSREVDVDGVSINSFDMERPSQPEVPRLPVYQRGSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9B8</accession>
    <name>U4L9B8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935312">
        <property type="protein sequence ID" value="CCX06779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9B8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6899" checksum="69BCC2A0B0F85093" modified="2013-12-11" version="1">MESKYPPCVFAIMLMLSYCRPDKSFSVGNSTAGLTEYRTPQTPLSIPLEYPRIDLLQVVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9P6</accession>
    <name>U4L9P6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9P6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15537" checksum="B7C907E6FBEA303F" modified="2013-12-11" version="1">MSVLIDLFGYIMMWPYISCALLMQPKRGIPGSNDIHIIPKPKLRTRPASNTSIPAPLLLPATTNVHDAFASLRQRYPRTGPHKLPFNTLNLVMISSIQLPVEFYFLQTLRMGIGLSKCHLPPEASLNMSPRFPSREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9Q9</accession>
    <name>U4L9Q9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9Q9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="237" mass="26753" checksum="1A126CDC9E3AC609" modified="2013-12-11" version="1">MAINPDIPFREKLRFYAGKGGILVNDELVTELNALSTRVMAQEQCMLDGFYKYRKHREQSSAAKLDKGFTANDIPSITQVYTTKDGDSSQRIGYLVRGEKAHCDIILSPLELRHAEFAITLPQQLNRDYNDALAPSTAIVPTQVILCNVNHILAVFYGYDEPGDECLRKTCNMLFDVTGVPRSGYWLYTERPSVHIPREYGVGDEEEAIETVMEMEREEKRRGVSALTVVDVEVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA43</accession>
    <name>U4LA43_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Pre-mRNA branch site p14-like protein acc. no. Q8ITY4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_10177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA43"/>
    <dbReference type="STRING" id="1076935.U4LA43"/>
    <dbReference type="eggNOG" id="KOG0114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HQPDKMV"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX10583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="13150" checksum="67C09798F57892F7" modified="2013-12-11" version="1">MNRGKLAPEVQRALFVKNLSYNVSSEELFDLFGKFGPIRQIRQGIANNTKGTAFVVYEDVMDAKTACDKLNGFNFQNRYLVVLYHQPEKMVRAEGDLQKRQENLEKLKKQHGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA57</accession>
    <name>U4LA57_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA57"/>
    <dbReference type="STRING" id="1076935.U4LA57"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YTRYFHA"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX16267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="451" mass="50521" checksum="01FC2AF2D70AD827" modified="2013-12-11" version="1">MTITSFPVYDLVCVGFGPASLAIAIALSESRPNARVLFLERQSKFAWHSGMLLPGTRMQISFLKDLATMRNPRSHFTFTNYLHEQGRLVNFTNLGTFLPLREEFNDYLSWCADHFVDVVRYSHSVEEIVPVDGQRQIREWDITATNEATGTVEKFTTRNVVIAIGGRPSIPDGLSSDPRIIHSSRYSSAIPALLSDSSAPYKIAVIGAGQSSAEIFQNLGSKYPNAKTSLFIRSHALKPSDDSPFVNEIFNPERVDEVFAMDAETRRKFKAENAPTNYSVVRLELIEEIYNEMYLQRLRSPDERTWKHKIHALREVVGQEWVGEEGRVRLKLRNTRTGEMEVTEDTYDAVVCGTGYKRDVHERLMAGSTHLLRDGSWAVGRDYAVLFKEGAVAQGSGVYLQGCCEKTHGLSDSLLSILAVRAGEMVNNIFGEPAKANGVSKKRFRTDEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAP1</accession>
    <name>U4LAP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Mitochondrial metalloendopeptidase OMA1 acc. no. Q9P7G4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936339">
        <property type="protein sequence ID" value="CCX16186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAP1"/>
    <dbReference type="STRING" id="1076935.U4LAP1"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="127"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX16186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="38082" checksum="61C22F06139C8B52" modified="2013-12-11" version="1">MFARSARTTLRTFRHIPHPVLRPSQITTRNAHIRFNLPQQGGNYQRFNNRRPFTQLWGNPNFKKVVGVGTAGAVTFYVYNLETVPVSGRRRFNVVSIESEMQLSQQMYEETVRQFHGRILPPNHPTTRRVRRVLERLIPASGLQDLDWEVNVIADNSIKNAFVIPGGKVFVFSGILPICGNDDGLAAVMSHEIAHTVAHHFGERMSSNLLVFVALILGGIALGDVDSVSRVGNTLLDLAYLRPGSRKQESEADYIGLMMMAEACYNPDAAVTLWQRMDAAEKVAVPQFLSTHPTNSRRIEDITKWLPEAREKQQISQCGSEMPKYANEFTRVMSGGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB49</accession>
    <name>U4LB49_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB49"/>
    <dbReference type="STRING" id="1076935.U4LB49"/>
    <dbReference type="OrthoDB" id="5337208at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="298" mass="33415" checksum="F4C4186D4406AA82" modified="2013-12-11" version="1">MNGQTVGTRHLNQLSSLNDTVSSFIKNTVIPAYFKSPSLIKMHGILSSQVFISNFKFDEDGVFSSTDNFAQNDISRLIRASYISSRNFLVDMIRAPPEPSPFRGNVTEDDRASFASAGFVLATRDVSTLSATVLIAVPSVLLLLSFILLSLEVKMRLAVTKDSSDQSSHKGRPLKDILISRLRYLEATQLYHFLNDSNCKQVDYDLQWRPVLNKPELELRTPYCLGASHPGLLPLSNIDDNNERSESKTGFEYTQLEKTASENALSMDMVSNTIPEDERPLIETLIRIKMQNRAFNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBE0</accession>
    <name>U4LBE0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936585">
        <property type="protein sequence ID" value="CCX17141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBE0"/>
    <dbReference type="STRING" id="1076935.U4LBE0"/>
    <dbReference type="eggNOG" id="ENOG502QVK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MGSCWLA"/>
    <dbReference type="OrthoDB" id="5406275at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="551"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX17141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="839" mass="94007" checksum="3EBF0A26D6B41173" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBI6</accession>
    <name>U4LBI6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBI6"/>
    <dbReference type="STRING" id="1076935.U4LBI6"/>
    <dbReference type="eggNOG" id="KOG2531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSCALGG"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="562" mass="61412" checksum="2E84C31255071CEE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBI7</accession>
    <name>U4LBI7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Putative diaminopropionate ammonia-lyase acc. no. P66900</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936318">
        <property type="protein sequence ID" value="CCX16150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBI7"/>
    <dbReference type="STRING" id="1076935.U4LBI7"/>
    <dbReference type="eggNOG" id="ENOG502RXDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQDTAWE"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="45"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="379" mass="40750" checksum="3A9430D2D968BDFC" modified="2013-12-11" version="1">MPLEIHPDLPGGIYANGIYTNPEAAEWTSEFLSSSNALEFHQRLPGYSPTPLLSLPSIASSLGLRHVLIKTETSRFGLPAFKILGASFATFRTLCAHFNLPDDATLEDIAVTADGKITLVATTDGNHGRAVAWMAKNLRVECQVFVPDFVNQPARDAIAGEGAVVNVVDGDYDAAVMVARTFTERAENAFLIQDAAWDGYRVIPKFIVDGYMTMLVELDLQAQEQIGRPVDVVLVPVGVGSLAEAVTIYYKRKGGSATTIISVEPETAACLQHSLRNGLESIETRSTIMAGLCCGTVSDSAWPVLSRGVDVSTVVSDMEAHKAVEDLKDLGFNVGPCGGATLAGLRRVAGLKLLRERLGEDFVVAMLCTEGARYYEKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBV4</accession>
    <name>U4LBV4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_03448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="HF936502">
        <property type="protein sequence ID" value="CCX16707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBV4"/>
    <dbReference type="STRING" id="1076935.U4LBV4"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENYHMIS"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="9">
        <location>
            <begin position="123"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="218"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="318"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="399"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX16707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="49136" checksum="E0F65AFD1E141726" modified="2013-12-11" version="1">MRCIGVPSVECGFKLIDRQTPRNTQLNTPPTTNTPGMEVSNTKDPDDDDDDAQRSIDFKLIASPGVLSFGSSTFQIIANTVSDTILKMVKVLAVLYDGREHAKQVPGLLGTTENELGLRQWLESQGHTLVTTSDKDGENSVFDRELVDAEIIITTPFHPGYLTAERLAKAKNLKLAVTAGIGSDHVDLNAANKTNGGVTVAEVTGSNVVSVAEHVILTILALVRNFVPAHEQVMAGDWDVAAVAKDSYDLEGKVVGTVAVGRIGERVLRRLKAFDCKELLYYDYQPLAPAVEAEIGCRRVEKLEDMLAQCDVVTINCPLHESTYGLFNKDLISKMKKGSWLINTARGAIIVKEDVAEALKSGHLRGYGGDVWFPQPAPQDHCLRYARNIYGGGNAMVPHMSGTTIDAQKRYADGTKAIIDSYLSGRHDYRAQDLIVYAGDWATKSYGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC32</accession>
    <name>U4LC32_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Similar to External scaffolding protein D acc. no. P69486</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_04241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="entry name" value="gpD"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="16937" checksum="E8C912DCBA48D5E4" modified="2013-12-11" version="1">MSQVTEQSVRFQTALASIKLIQASAVLDLTEDDFDFLTSNKVWIATDRSRARRCVEACVYGTLDFVGYPRFPAPVEFIAAVIAYYVHPVNIQTACLIMEGAEFTENIINGVERPVKAAELFAFTLRVRAGNTDVLTDAEENVRQKLRAEGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDK9</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">PCON_08296</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="CCX30194.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="9" mass="1040" checksum="C900D415A5A1A72D" modified="2013-12-11" version="1">MALTSSRFK</sequence>
</entry>
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    <accession>U4LDM3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">PCON_06288</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDM3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9237" checksum="A23E11D598238626" modified="2013-12-11" version="1">MSVSCSPTREEKSSVSPRLRPTRSAWPDSDSRSKHLSYDSPGSDDGGLKILVGGKLVRLWMQWYADKLLEGYKKALSTFFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF44</accession>
    <name>U4LF44_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF44"/>
    <dbReference type="eggNOG" id="ENOG502TFPW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3789824at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="298" mass="34293" checksum="ECB1B8BACB4AFCE0" modified="2013-12-11" version="1">MNTPHQWKEISRRGFRLLTITAIVIMNGIPIIRMFNIYVRDLQVKLDSKITPIESGCVTVFLWKINSWSTEVLIAIASWIICVVSLLISIIRQLRYELRKPESRCSTLLQLLRIPNPVKDRTTTTPPEVDTEAQSSTQPPTLPTKILKILSLTVYTIIYIYLQALPLYYLWRIRWMRRHVRSIIQPPSPSNILYPPFADLQSSLAEELNNWDNDDWSFGQILTLSLWSPALLEFFYILIAGEDCVLTGRLPENWKAVEDLNSKAKHDIENDDEREEVASQATPKTTPEKTPGQTTAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFH2</accession>
    <name>U4LFH2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Carboxypeptidase Y inhibitor acc. no. P14306</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFH2"/>
    <dbReference type="STRING" id="1076935.U4LFH2"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNPQEPN"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651325" evidence="2">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="331" mass="34353" checksum="B0A260297EE0FDDA" modified="2013-12-11" version="1">MLPLLLLLPALARFALGQIPTEFSATFDKTSGIQLVVSLGGKEIKNGQLVPLAETKQVPTFALGQSSPINTSSKYIIVAIDPDAPSRANPTVAQVLHYMNTDFSPMSGTATNITSSNEQETVKYMPPGPPKGSGEHRYVWLLYQQPQGFEAKDVPTRNRTGFDVAKWAEENGLKPAVAGIFWVSEFGDGKAGGGNSTDSPSTPKPSGGRGRGNGTASDVPKPSGVRGGGRGNSTATLIGSGNSTRTATQSRGRADTATPVITDAPTGSEDTGPTMTMTAIVTLPPLSGADGSNSTGNGTIVSKLPGSDAVGIFEEKVWWLLVAVLGAHFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFW6</accession>
    <name>U4LFW6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFW6"/>
    <dbReference type="OrthoDB" id="5459985at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="334" mass="38595" checksum="B76D5A8C52A9EEFE" modified="2013-12-11" version="1">MSTENSYEQSVDSSTQASSTPGPDTPSVSEIMSTTPTAELQVASPAYENMFRSFLDTFENLRAEMTRLEIENKRLVDYNTVIEKELETLNEENVKLSRANDDAMKKLAESDEKNARLQKEFSELEELKEVLGWKKRCEELENRTTENQERTEKLLEDYQQKTEKWIAEVQQQSQRNLGQAINRIKALRALQMQGLNSVMAFMGLEDLKDGYIFREKPLKMIPNGMIQVSRAKAASANQLSDDPLYENEGSGFLYVVRDQYKDFEKFTKIAESVFRLGAGHLWWLQGTKSDFPMCCRPGGMFHFDKAGLINKWQKVASQKDRIYISRFTLYYVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGF0</accession>
    <name>U4LGF0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Sterol esterase 2 acc. no. Q07950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935555">
        <property type="protein sequence ID" value="CCX10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGF0"/>
    <dbReference type="STRING" id="1076935.U4LGF0"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYCTNDD"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="211"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="620" mass="70453" checksum="942B042DEE568648" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGJ3</accession>
    <name>U4LGJ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Probable tocopherol cyclase, chloroplastic acc. no. Q6K7V6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGJ3"/>
    <dbReference type="eggNOG" id="ENOG502RXN0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIHQEKN"/>
    <dbReference type="OrthoDB" id="5421239at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009976">
        <property type="term" value="F:tocopherol cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025893">
        <property type="entry name" value="Tocopherol_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309:SF4">
        <property type="entry name" value="TOCOPHEROL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14249">
        <property type="entry name" value="Tocopherol_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="387" mass="43308" checksum="51949CCDC3207D4F" modified="2013-12-11" version="1">MPLPPIYSILTEPVKFLIALTPLERFVAKKDHFAPHPNAPFEGYYTRILTTTGSTILLIFSSVFKAAEHPHFVHFSLLPRNGSSEHRIVVNKFPRITDANGTKHPNSVHEFSRVAKGDGVEGTYRICKDEQRYRLELDTEEFGKLEVSVDLTDRKAWIPGNDTSTPEGIFAKLIFLLPLHWNVWSTASTAKYTVTSNGKQLEAGEGIAHIEKNWGASFPDGWTWVQGFSQSPDSGVARHATRTFVMTGGKTTGSKAYLCGYRSEKVEFSFKPLWTLMPFSFQTMFIKESFDSKQGTGRWEFCGLWQRLVVEAQAPSDHEGWIGLNCPISSGHNNCLAYESFDGSVRVQAYKRGWTMGWELVEETVFDGAAVEFGGDYSFKASMSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGW4</accession>
    <name>U4LGW4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_10612</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG0970">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA replication origin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:leading strand elongation"/>
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        <property type="term" value="P:mitotic DNA replication initiation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="480"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="791"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1276"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="68"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1467" mass="165364" checksum="10C1DF6C7FF272D0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHA7</accession>
    <name>U4LHA7_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31288.1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="14879" checksum="959970730E8FD33F" modified="2013-12-11" version="1">MMQQFCRTYAFKNSWKEMADVPEKLEDRWDWWYNNYREKIETLDEQGSPLQFYDVRKPDFGVICQLLLAEGDCDLKEYWENCRLHPGHVEDWLDDYFVDDPAAIKDAALEFPILNIAISDFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHW6</accession>
    <name>U4LHW6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHW6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4843" checksum="0D65A4B8A6211A45" modified="2013-12-11" version="1">METLNNSTYRMYEFLTTLGNTTEDAVRIRVGLCEYASPLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LID9</accession>
    <name>U4LID9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LID9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="16697" checksum="8A0F257702F72FB0" modified="2013-12-11" version="1">MADRKGKASETPKKWGKFSSFFSPLKNFASSFKPHKNVKRYKISAPIEIAQTKQVVTTLISLEDAESLPPSAIPSGAIVVISLDAARKKFTGVLPYILDDTFTISGGGIDSGSSTSSGSSMGSFQWSFLETRPDSGFGDGTVRESMDQDSLGWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIS8</accession>
    <name>U4LIS8_PYROM</name>
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        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935652">
        <property type="protein sequence ID" value="CCX31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIS8"/>
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    <dbReference type="eggNOG" id="KOG1897">
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    <dbReference type="OrthoDB" id="433457at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
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        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="13"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="424"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="775"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="919"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="875"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1241" mass="134703" checksum="33BC9F347D9F5920" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ31</accession>
    <name>U4LJ31_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCON_12379</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 100304</strain>
            <tissue evidence="24">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ31"/>
    <dbReference type="STRING" id="1076935.U4LJ31"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="76"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="223"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="481"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="581"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="710"/>
            <end position="1087"/>
        </location>
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            <begin position="1089"/>
            <end position="1173"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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            <begin position="1069"/>
            <end position="1089"/>
        </location>
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            <end position="28"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCX32109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1182" mass="132399" checksum="022003C5AEF40100" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJI0</accession>
    <name>U4LJI0_PYROM</name>
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        </submittedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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            <begin position="24"/>
            <end position="67"/>
        </location>
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            <begin position="88"/>
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        </location>
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            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21204" checksum="7447F6C93627189A" modified="2013-12-11" version="1">MTKRIAFCNTPLFTHVAQNFSHHINAPQPTEDNSSSLFNKDSSPIAKSPESTTSSIKPTGPLDTIGKGRIELTPLTRDPLFMQSGANTSYLNTTIPDPPPQFSSSSPTQHGLLRTESLGEGSPQRPESGTLQSDKLNGTLTPDTDKANRIAQYEAMGGFPSYGGGQDAGFIVKRTNWAGRALGDTPISKYPNGRILGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJM0</accession>
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        </submittedName>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF06985">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="565"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="611" mass="68369" checksum="FCB67383917C66F7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK81</accession>
    <name>U4LK81_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_12054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK81"/>
    <dbReference type="STRING" id="1076935.U4LK81"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDMKVLA"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="545"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="639" mass="69735" checksum="755D11E49C953647" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKI7</accession>
    <name>U4LKI7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKI7"/>
    <dbReference type="OMA" id="TPDPHRN"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="452"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="533" mass="59640" checksum="CA72B0A0B6B4B76D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKU3</accession>
    <name>U4LKU3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Peptide transporter PTR2 acc. no. P32901</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935728">
        <property type="protein sequence ID" value="CCX32197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKU3"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMQDMSD"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="566" mass="62587" checksum="F99A3371FB8A64C5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLQ3</accession>
    <name>U4LLQ3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">PCON_14095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLQ3"/>
    <dbReference type="STRING" id="1076935.U4LLQ3"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="287" mass="31890" checksum="B70FDE721D687C4E" modified="2013-12-11" version="1">MHVTLHGPTLNIPHYIPNSLVNFWQLHAQLSSIQLSTNSSSAPPSSQAPCTLTQPIMDLFGDGSFVGDDLVAPAPIMEAKITSADFGLLEKPILIHEDLAKGCGGMIWPAGEVLTKWVLKKYMGTTELRGKRIVELGAGGGITSLAVAVGCDLEGADLYMTDMKAMYELMKDNVKLNKLEDKIKVELLDWANPVPDAIAEKPVDIILAADCVYFEPAFPLLEKTLVDMVGENTVVFFCFKRRRRADLHFVKAIRKRLHIVEVDINNDPDYEAFKRENLFLYIMTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM80</accession>
    <name>U4LM80_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to 54S ribosomal protein L15, mitochondrial acc. no. P36523</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM80"/>
    <dbReference type="STRING" id="1076935.U4LM80"/>
    <dbReference type="eggNOG" id="ENOG502RXWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AHTMYAV"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="107"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="266" mass="29770" checksum="DECB6708E4B02B65" modified="2013-12-11" version="1">MASNTTRQASSLLSISLRPRSVGLVSKRAIAPAAQRYVHENSENASKYERQPTRLPYSNPEYIQNARPQPRAPVAPRARKHFQVNDDPAVLNRMYLKLFGKEMGLSEEVKWQAVTHKSFDHGRQPFNSKLRFFGKRLLQMHASLSLLNSQPTNSTEEAKPTVYKSLEGAHYQNPEPFVHEDFKNIDAVTQENIEKALDSGLLMPIIKESGLADVMRWKPADGNDLLRSGQGIIAIECFHAIVGALALQKGGEVAAQFIKEKVLKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMT3</accession>
    <name>U4LMT3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMT3"/>
    <dbReference type="STRING" id="1076935.U4LMT3"/>
    <dbReference type="eggNOG" id="ENOG502QRX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETIHYTL"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1158" mass="125349" checksum="587279182D453AC3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMV9</accession>
    <name>U4LMV9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMV9"/>
    <dbReference type="STRING" id="1076935.U4LMV9"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="319" mass="34791" checksum="608204B37BBFA6C3" modified="2013-12-11" version="1">MPFRFFAADPDSDDESSVAAPTTNENTSDPGDAAPFLPPVLHPLSTLLPTLPPNIAYNFAPTVPLLPRRAVFDTEMQLKTSDTQLSDLGDHDIRRRIYEGGLKSWECSIDLATYLSDTITTIPSKTLELGCGSALPSLMLFRKMLEEKKGGTIVLADYNLDVLKLVTLPNLVLVWGVHKGLIKGEEKGDFDAHELFSAEAFEKELKEAGIEVVFMEGAWGGDMNQLLGETVEGGKFDLVLGSETIYEPETAGRFTDVVLEAVVENGKALVAAKKIYFGVGGGVDDFVKDVEGRGSYSCHMVRDFKSAGVNREIVEVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP82</accession>
    <name>U4LP82_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP82"/>
    <dbReference type="STRING" id="1076935.U4LP82"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRSYFHY"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="316" mass="36605" checksum="36BD4FAAA27B65D7" modified="2013-12-11" version="1">MLLLDYHNPLLKTILKERFVKPAAIDQIISDFDGVTYHIFTPEVKTKILISISIKCYQDLLQHGAEEVLKREYGSYITETEQGYNFSILIDLTALPEDPEERNDLITRVSLLRRHTMAAPFEKAISIQQSLSAEAATDPSVTTKTSEVMTIRYRDEEAIYVQASYDRVTVIFSIVFREETDRVLAKTFMQEFVDARKQIQMAPHVMYRSDPPLEIRGLPGVPEAGVAVKKGDIVYITFVFFPMHIENKAKREHAIEHIQTFRDYFHYHIKAAKAYIHSRMRHRVAHNLKVLNRAKPENEMEEKEKKTASGRTFKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPB7</accession>
    <name>U4LPB7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to WD repeat-containing protein 5 acc. no. P61964</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPB7"/>
    <dbReference type="STRING" id="1076935.U4LPB7"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKGHDTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="48"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="350" mass="38084" checksum="ADC53C04CB580F4D" modified="2013-12-11" version="1">MTTPPTPNSSLPPRRTRFDQTSPPLRSTPSTTQESPPPVRPEYALKFTLKGHSAGISAVKFSPDGKWLATSCNPPPPLYAKLANRLTLTTAADSTLKIWHSLSGAHEHTLTGHQAGISDLSWSPDSLLLCSGSDDKTVRLWDTLSGKLWKTLKGHHNAVYCVSYSPRGTIIASGSYDEAVRLWDVRSGRCLKTLPAHSDPVSGVGFNRDGTIVVSCAHDGLIRIWDVGTGQCLRTMVEEGNVPVASVRFAPNGRYLLAGTLDSSVRLWDYVQGKTLKTYQDHRNEKWAVAADMCGSEDSDVFLWDVNSKEPAQILVGHEDVVLGCSAHPTEKVLATGGLDKTVKIWVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPI1</accession>
    <name>U4LPI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Membrane protein PTM1 acc. no. P32857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_10361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPI1"/>
    <dbReference type="STRING" id="1076935.U4LPI1"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651635" evidence="9">
        <location>
            <begin position="22"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="179"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX31230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="548" mass="60879" checksum="EED5672357937947" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPN4</accession>
    <name>U4LPN4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_01384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651787" evidence="1">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="14534" checksum="5384FAA0A173A11F" modified="2013-12-11" version="1">MYASSLLPIGLFLLSGSPVILASTTVPMKNEVRVTLFSKPNFEFAPPYWYGSHDLTKRLCVNLPREHHGHVESYLVEGGCCTFYEKKDCKKALFSANRKADRKLGPNHRNKIESYQCGKPGCKLRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQS7</accession>
    <name>U4LQS7_PYROM</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_02177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2139606at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7219" checksum="B1208CC63E8ABBA3" modified="2013-12-11" version="1">MCLCSLGGGGGNYGGVFATIVRLFSVNAINAYITSWALTLIGENDSRMLFPAWIFVASIDHLPQQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRN6</accession>
    <name>U4LRN6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX34625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="9974" checksum="425B8CBCE3A11325" modified="2013-12-11" version="1">MVDFKKRSTSANGNSGVLGSPILLKTSGNSLKTWSVHISGSRLFGRVISAMDTDTASPPVAFLMTPAMILTVPAVKSGPPFGRDLPSTGNNLASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRZ4</accession>
    <name>U4LRZ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRZ4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8919" checksum="C59240333974E344" modified="2013-12-11" version="1">MSRIRRAPKQITVTTEEGWELMTDPNAVPTAEDIEELEEILGKPSNNTRAWLRNNAGFIARTGFQVALGIIEVVIRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS54</accession>
    <name>U4LS54_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS54"/>
    <dbReference type="STRING" id="1076935.U4LS54"/>
    <dbReference type="eggNOG" id="ENOG502RZ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWGFEDP"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="358" mass="39135" checksum="712D0E1CE38C66C2" modified="2013-12-11" version="1">MRVLTTLPRTARAFTTTIPSFKDAAAAATAPAPPSPFKAHLTDFNSLSSSINTHLISSPDTSLPEFAVLDALVSLRAHVEHVLSLNKPGSTSSPTSKSKKLLFTENSADFTGITNLAYELLADPRVFLTIELLSAFVSLQTLTRDPTPIPAVFSIYANKPYVPEGGGAPKTPNHKQAKYAIPTGISEAALDVAIDTRNMETALDIVDTSYAAPAWKRNKMIRQALPVATMAAVSPAVLWIAADQLAAFQDTVEHTLAKKYAFSGLLAYTGFTAFTALLVVGTRNDQMVRVRYIKGTPLRERWLREEERAALDRIAMAWGFEDPHKHGEEVGEEWEMLREVVGRKGMILDDPELLEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS67</accession>
    <name>U4LS67_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to pH-response regulator protein palH/RIM21 acc. no. Q9P904</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS67"/>
    <dbReference type="STRING" id="1076935.U4LS67"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMAYSIS"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="519" mass="57007" checksum="7B8C242EE8D0E8F4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT78</accession>
    <name>U4LT78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Putative methyltransferase C2C4.06c acc. no. O14039</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT78"/>
    <dbReference type="STRING" id="1076935.U4LT78"/>
    <dbReference type="eggNOG" id="KOG2360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFKSRIY"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="628" mass="68667" checksum="432BCE12C62E5B0E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTD6</accession>
    <name>U4LTD6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized protein YMR185W acc. no. Q12751</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTD6"/>
    <dbReference type="eggNOG" id="KOG4653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KRAYGAP"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="4">
        <location>
            <begin position="262"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="769"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119700" checksum="4FB68395752A9F97" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU42</accession>
    <name>U4LU42_PYROM</name>
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        <submittedName>
            <fullName evidence="13">Similar to Serine/threonine-protein kinase ppk15 acc. no. Q9P6P3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_10614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX31331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU42"/>
    <dbReference type="STRING" id="1076935.U4LU42"/>
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    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="445"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="995"/>
            <end position="1039"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
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            <end position="150"/>
        </location>
    </feature>
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        </location>
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            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="811"/>
        </location>
    </feature>
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        <location>
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            <end position="902"/>
        </location>
    </feature>
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        <location>
            <begin position="903"/>
            <end position="938"/>
        </location>
    </feature>
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        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
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        <location>
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            <end position="1025"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118447" checksum="6F8E6D8FD6BF04C7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUI2</accession>
    <name>U4LUI2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="104"/>
        </location>
    </feature>
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        <location>
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            <end position="145"/>
        </location>
    </feature>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23563" checksum="1B25AF32E483AADC" modified="2013-12-11" version="1">MSPTTQNNKPFRSYYGHESRYYTAQTPATVFTQTSSVVVFSSGTSSVVVFSSGSSSSQQLSPFTTPESTSTQDTANTTLERGSYAEAATQTVQSQGYANACTQTTPPPPDHRYRRSTTPYSPAPGYLSRAPSSRPGGSSNSSARGHPLARTPPWRKPNNEGYYRRWERPADFGESSRGLLGPPYERDSNRERDRNRERDGDWNELRRWRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUK7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="7886" checksum="51DE2B3AE51D6409" modified="2013-12-11" version="1">MNDRWTMALRYIQAPGHSNGVINCEWDPKTVLHCTTAIPEPRPDFSATAAFVSRFLSQEEAALLDLASSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUL7</accession>
    <name>U4LUL7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11415</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUL7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6727" checksum="DA525EEC6159D376" modified="2013-12-11" version="1">MLQYCYTGKYSKECNDVLNKEGEQLYSAHIEVFLLADMLNIGDLMELASWSYSQLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUU9</accession>
    <name>U4LUU9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUU9"/>
    <dbReference type="eggNOG" id="ENOG502S0Y4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYITTAF"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651929" description="Beta-xylanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="8">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="331" mass="37139" checksum="7C0805C0C5747E6B" modified="2013-12-11" version="1">MKLLTLLLTLATTSLVHGCLDQKMKAHKRVYIGAATDPNTFNDTLVAQHLKTEFGCVTPENSMKWESTEPSRNTFTFSDSDKLVQFASSNKKLIRGHTLVWHSQLPQWVHDITDKAVLTEVIINHIKKVAGRYRGKVYAWDVVNEVLSEDGTLRPSVFSTVLGESFIDLAFRTAHAVDPHAKLYINDYNLDGPGPKIDAMIALIKRLQRRGVPVHGVGTQCHLILGQVGAVPAQLQRLGGLNVDVAITELDIRIPKPLTPELWRQQQEDFHTVFKGCLKVERCVGITAWGVSDKYSWVDTYFPTFDSPLLFDDYMNRKPAYDGAYAALSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUY5</accession>
    <name>U4LUY5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_02617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUY5"/>
    <dbReference type="STRING" id="1076935.U4LUY5"/>
    <dbReference type="eggNOG" id="KOG1706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="179"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="414" mass="46517" checksum="470C4B9724B25F5D" modified="2013-12-11" version="1">MANKEKVCLAYSGGLDTSCILAWLLEEGYEVICFMADVGQEEDFEAAKEKALKIGASKVYVEDIRKEFVEELCYPAIQCNAIYENVYLLGTSLARPVIARAQIAVAQREGCVAVSHGCTGKGNDQVRFELAFYALQPDIKVIAPWRMPVFYERFAGRADLLEYAEKVGIPVTQTKSKPWSMDENLAHCSYEAGILEDPDMEAPKDMWKLTVDPRDAPDAPEDFTIKFEKGLPVKLEYENGKSVSEPLDLFLVANAIARRNGVGRIDIVENRFIGLKSRGCYETPGLTILRSAHVDLEGLVLDREVRALRDQFVTYNYSKILYNGLYFSPEREFLEDSIRASQKSVNGTVRCRVYKGNFQVLGRSSETEKLYDMSESSMDEIGAFAPQDTTGFISVQAIRLKKYGNSKLEKGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV84</accession>
    <name>U4LV84_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="8"/>
    <dbReference type="EMBL" id="HF935806">
        <property type="protein sequence ID" value="CCX32301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV84"/>
    <dbReference type="STRING" id="1076935.U4LV84"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SQPCESG"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="32625" checksum="406C25B3DA74BC96" modified="2013-12-11" version="1">MGKSSKDKRDSYYRLAKESGYRARSAYKLLQLHDVFGLLSIPSDAPRVVDLCAAPGSWSQVLSRTLPNTSRIISLDLQPMTPIQGVVTLQADITHPSTLPLVLNHLGGEKAHLVISDGAPDVTGLHDLDEYVQASLLLAALNLAVCVLQPGGNFVAKIFRGRDVDVLFAQLRTLFTRVTCAKPRSSRGSSIEAFVVCEVYAPPKGFEPSLERPLALGMLDDGLGEGATVELADDGEIVEQTENGEVVRYVVPFVACGDLSAYDSDATYHLQEGRESIDPVQPPTAPPYKRAVELRKALGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW43</accession>
    <name>U4LW43_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Translin-1 acc. no. Q9P7V3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_14186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW43"/>
    <dbReference type="STRING" id="1076935.U4LW43"/>
    <dbReference type="eggNOG" id="KOG3067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DAFHFTI"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="31036" checksum="20D067062D13C17D" modified="2013-12-11" version="1">MAEQVYSAIDQDIFATVTEQIEQDLVIRESIKEVLKNLDKQLKQISATLSRVHSVPPSEVPNLITKTQPIFEAAKSDLHELVEKTKPYPYYKYNGMWQREMQNLIFLILFETWLSRSYLPTTVPVNALATIEEVGARLSIPINLKTEDAFHLTIEEYLHAIISLVEELTRLMTNAVTQRDFKRPMLISTFVKDIHSAFQVLNLKNDGLRRRGDGLKYHVKRAEDIGYDLIVRNLVDMGVEEKAEEKAEEKAEEKAEEKAEEKAEDKMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWB9</accession>
    <name>U4LWB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="9" mass="1133" checksum="0638F5B325A6D9C0" modified="2013-12-11" version="1">MIFQSKSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWK4</accession>
    <name>U4LWK4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Signal recognition particle SEC65 subunit acc. no. O13475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWK4"/>
    <dbReference type="STRING" id="1076935.U4LWK4"/>
    <dbReference type="eggNOG" id="KOG3198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="32469" checksum="EA314E01B0998170" modified="2013-12-11" version="1">MSHHAYIEDADSDPEEIDISVNPDALDLNLSSNTYSTAPRFDRPQFSSRSAHPVGSTPPAPQGNPFLDPNLLASLTGGRGLEGLGGAGGFGGLGGQGGQGGPQYLSEKQAQEFKHYQCLYPVYFDADRSRQEGRKVAKSLAVKNPIAREIADACASLGLKAVYEMAKSHPKDWANPGRVKVLLKEDGEPLVKGIPNKFVLYQKVALYLIAHPTQPETPLKVPVPGMPFDGKVPKPPVVPRGWKMGEILPLHSPALSGPGVTEDVFSQMMEGMGMGGLTGGPSGAPTGAPQIAEKKEKKEKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LY19</accession>
    <name>U4LY19_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Cell division control protein 48 acc. no. Q5AWS6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LY19"/>
    <dbReference type="STRING" id="1076935.U4LY19"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="525"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="817" mass="89010" checksum="9160322F7B22FDAD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LY64</accession>
    <name>U4LY64_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LY64"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7176" checksum="6600B0971DE45A6C" modified="2013-12-11" version="1">MSMLDEVRSFLRFYYDEILLNGQGRQITPMSPSPINTILLYISPPASTFGETSDTSLRSYAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTR6</accession>
    <name>U4KTR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Alcohol oxidase acc. no. Q00922</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935197">
        <property type="protein sequence ID" value="CCX04293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTR6"/>
    <dbReference type="STRING" id="1076935.U4KTR6"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="590" mass="64458" checksum="C1D97DAAACA03A9B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU24</accession>
    <name>U4KU24_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to KN motif and ankyrin repeat domain-containing protein 2 acc. no. Q1LZH7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935200">
        <property type="protein sequence ID" value="CCX04372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU24"/>
    <dbReference type="OrthoDB" id="6600467at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="144" mass="16314" checksum="05E8EB2C1C8CCFAC" modified="2013-12-11" version="1">MALPHSFGQPRMDMPILYVYLYHEPKSVLADYDGNTAPMRAASRGYGEIVSLLLSRPDIDCGLKETKSGFRAIELAAHNGHTEVFSFLKEHERTNNCPIHVEHDDSTLEPQFLQKTYSKPVSRLSIPIAKLSWYYPFRSSAEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUE9</accession>
    <name>U4KUE9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUE9"/>
    <dbReference type="STRING" id="1076935.U4KUE9"/>
    <dbReference type="eggNOG" id="ENOG502S6P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67669" checksum="33C8F72F3D70C076" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUG8</accession>
    <name>U4KUG8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Eukaryotic translation initiation factor eIF-1 acc. no. P32911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUG8"/>
    <dbReference type="STRING" id="1076935.U4KUG8"/>
    <dbReference type="eggNOG" id="KOG1770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="192" mass="21634" checksum="4172E3C99342F86E" modified="2013-12-11" version="1">MSTMEKLFGKKFNTPILRPMAPFFIAGVVVAYGINSFANLLASTDEFKNDPRNPAAKKNADVQSEHTLSPLTPRTKKFMSIENLKVNDPFADDVGDTQPKNYVHIRIQQRNGRKTLTTVQGLSKEYSPKALLKAFKKEYACNGTVIIDPDMGEVIQLQGDHRTKVMDFLTDKDKSKMGKYALQKDHIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUI3</accession>
    <name>U4KUI3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUI3"/>
    <dbReference type="OrthoDB" id="10685377at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="259" mass="28559" checksum="827288438AD6D744" modified="2013-12-11" version="1">MVIKETTYYTVEPPVRGSSLGKTTVTHTEEDTLRQAYLPPDGRRGLKERVITTPPVKYVSASAKVAREAIPVDTSKPRSITRALHNISTPAAAGGPSPVATVESSSAETPDSLSMLYSNDNLPRLGTMDSLHLTNSYASSSYRQATPRNYRNTKGIPTTLLNLDPDDPSNRFYSKALNAYLPFPTEVPDEVEQQRPGTRKMIADQAKRFVSIIRSKKRGISKNIIGIPRGGEEVVDSWRRSVLERKAKQDAKVRMDSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUZ6</accession>
    <name>U4KUZ6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUZ6"/>
    <dbReference type="eggNOG" id="ENOG502SDVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5222339at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="176"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="380" mass="42062" checksum="DAE0BC49ECB8EAB2" modified="2013-12-11" version="1">MSSATDLFASLDLDSGLDLNALCSINEFRKQEPISNDIDPVPHPVVSGEPIPVSASITTTYVKDLHELLQSSEYWNYNITPVFDYELVTTEKIHGYQSVLKLECKNTNTLVREFRNEGSAPSKKRAKEEVASMGYNWVFSKEGKEVIGNLPTRSTDAIALNGKGHQQETLETENWVGMLQDFCQQRCALPKYTFYARAMDQPQGFSCDITQIPGLEEQVFGNKTLFYRNKKLAKVQAAKHAMQFINATNPPLPESALKTKLGRRTAAASAGGNFVGGAQLLPSGSIINIPFRAGPVESVTIICPKLGMALPEYDITQDPTAPAIYDVTASIRRQQGKTLRIGPMKGIYGRRNAKERMAESLMILLKNQAEQLGITIRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV29</accession>
    <name>U4KV29_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV29"/>
    <dbReference type="OrthoDB" id="5429853at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="237"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="650" mass="73019" checksum="DB9ECB55144E39C5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVP2</accession>
    <name>U4KVP2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVP2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="272" mass="30707" checksum="7F6D1BA22DA87EFA" modified="2013-12-11" version="1">MAPLNNQLSRRSLHKAQRRDTASAVMNIPEDTSKCEEPVVAAPQSAFQSLESVHVNYKSLRKECNDFLFLHKRIDKSDDSSSIESLVNAAKSLPAPFDPSRPEVHNRFQADQSKLSKQLEAIYTSIERFLPEYINTQAECDLWGAHLTAIEEYLKAQSEHQSLLLLMSPDRVSLDSAAKKRLEAQWSRANLYSRITQFISKDKFSNDFRAIFTQVLDDCRAQFEKPSRKSNAPVPIELLAEETGLEQLEPGSFIGISPNEDPYMPLPGPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW21</accession>
    <name>U4KW21_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935239">
        <property type="protein sequence ID" value="CCX05236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW21"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="21642" checksum="51572FC950B8F5FD" modified="2013-12-11" version="1">MMAMQAKDNYKLPQLLDQLNNDSEFLGNQTEDCIPMWQQFTGKICSFYETEKTETVTGGTAKRGGPKVPKVMRFSAVVRVRQEESVPINSNHTDMVYFANAEGKFLTVVRNMTEWLAVTKSENEELRCSQKYIDCRKSLKPSDYEGYRDELWRKRHGNYCKWLLHDKRYKAWAEENHQPILWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW91</accession>
    <name>U4KW91_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935267">
        <property type="protein sequence ID" value="CCX05707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW91"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="10095" checksum="A06184D106490B20" modified="2013-12-11" version="1">MKRNGKDIQEQVGDMSRNHLVHQRNAAMESNNLGIRRMSCRSILGLRKPRPRRQILLSSVGRLGVGKRRRCMNWVSMCSRPYGFQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWX2</accession>
    <name>U4KWX2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWX2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13416" checksum="51B79B275BDB1B82" modified="2013-12-11" version="1">MAVTSKRKNRRDDARSRKRRRRQFDSPRALPSIDSGLSTTMPSTAKSPVVPAPSTSDEPSTPTQPSIPVGPSTESTPPAASLNSDGISYFATEQEFHQYFAEHKVTATDLAQKSFQCWNQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX86</accession>
    <name>U4KX86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935276">
        <property type="protein sequence ID" value="CCX05916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX86"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2065" checksum="8A152F689A122C9F" modified="2013-12-11" version="1">MDLGGSFALSRTPRTPQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXI8</accession>
    <name>U4KXI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to L-amino-acid oxidase acc. no. P23623</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXI8"/>
    <dbReference type="STRING" id="1076935.U4KXI8"/>
    <dbReference type="eggNOG" id="ENOG502QWMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTHAWIE"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651716" evidence="1">
        <location>
            <begin position="28"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="677" mass="76279" checksum="9208660A93F16179" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY34</accession>
    <name>U4KY34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Sugar transporter STL1 acc. no. P39932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX06871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY34"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
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    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="10"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX06871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="573" mass="64117" checksum="FE7BE85A594DC80B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYS8</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="16715" checksum="9301084E719E60CD" modified="2013-12-11" version="1">MCTQSYAPTAMSRNHLFAACIRIPNRSCSTGWRTLTSCNPGFQVFRVYDHARVGIEFIPLPRRRTSLSTRTDGRHLPSGSGKENVVVPSRANKHKRHENEQAVILPRTTKRKLQDNEKAAEWQNFAPHIRVIVLYLKQRPGGHSSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYU1</accession>
    <name>U4KYU1_PYROM</name>
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            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PCON_06738</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
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    </dbReference>
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        <property type="entry name" value="AZUL_sf"/>
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    </dbReference>
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        <property type="entry name" value="HECT_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="703"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="981"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1283" mass="144318" checksum="C763C1211409EFEF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ29</accession>
    <name>U4KZ29_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Phosphoethanolamine N-methyltransferase 3 acc. no. Q9C6B9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935364">
        <property type="protein sequence ID" value="CCX07700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ29"/>
    <dbReference type="STRING" id="1076935.U4KZ29"/>
    <dbReference type="OMA" id="ICNDAIN"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="366" mass="41457" checksum="E7A98EC1DA58BAE1" modified="2013-12-11" version="1">MSAPLDEDGANMTSTGRNSTDNATIHNVAAITVDPQIQYDIDNDVDTDYSDRELNDATFSVTSTIYNYREENGRTYHRYKDGAYLMPNDEMEKDRLDIVHHMYLVLLEGHLTLAPIDTEKPLKVLDVGTGTGIWAMAMADHLSEDSEAIGTDLSPIQPGWVPANCRFEIDDAENEWTYDTNHFDFIHTRHLSQSIRDWPAYISRLYDHLRPGGWIEIAEHGLRCYSDDGSFPLDSPLALYTEKLCEFGRREGFLVSSNPGNKLKEMVIQAGFTDVRHVPYNLPWGPWAEDERLKELGRWAFITFKTGAAAYGLALLTRVGGITGEDAQRICNDAINTLNDWRLHVYNFHHFIIARKPMPGEVVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZF9</accession>
    <name>U4KZF9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935232">
        <property type="protein sequence ID" value="CCX05074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZF9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8852" checksum="196B1A8704943FBF" modified="2013-12-11" version="1">MKLRMQHAPSLPTIISRAFRRHCHTTLQLTIANKTSPTHMCYQQQPLHPQSPPIQLDFRSDLSMMLQNPSFAVGVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZQ4</accession>
    <name>U4KZQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Translation machinery-associated protein 64 acc. no. Q04600</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF2D family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935343">
        <property type="protein sequence ID" value="CCX07225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZQ4"/>
    <dbReference type="STRING" id="1076935.U4KZQ4"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFLKPYR"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="4">
        <location>
            <begin position="401"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="516"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="606" mass="65806" checksum="F78E1208C4804B5C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZT8</accession>
    <name>U4KZT8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Potassium transporter 5 acc. no. Q9M7K4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_04821</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935239">
        <property type="protein sequence ID" value="CCX05234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZT8"/>
    <dbReference type="STRING" id="1076935.U4KZT8"/>
    <dbReference type="eggNOG" id="ENOG502QPSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VTFITTC"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="157"/>
        </location>
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            <end position="281"/>
        </location>
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            <end position="308"/>
        </location>
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            <end position="370"/>
        </location>
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            <end position="416"/>
        </location>
    </feature>
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            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="565"/>
        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="815"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="692"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX05234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="815" mass="90464" checksum="29B556E3E3C896ED" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L066</accession>
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        <submittedName>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="48125" checksum="6EFC5DAD7978768B" modified="2013-12-11" version="1">MNLQLLSLALVASLTSLANASLQIVSGGSWTASNGAHLQAHGPGVTKVGNTYYLIGENKLNGSSFQSINCYSSTNLVEWTYVGELLTLQSSGDLGPNRVVERPKVIYNDATEQYVMYMHIDSSNYGEAKVGVATGTSVCGKFTYRGSWRPLGFESRDMGLFKDDDGTAYLMTEDRSNGLRIDRLSSDYLNVTSNVYTWAEKYESPAILKRNGVYFMFGSHLTGWNTNDNIYSTATSLSGPWSAWKTFAPVGSNTFTSQTSFILPVSNSFAMFMGDRWTPSNLMASTYIWLPLTVSGTTASLTWYDNWIPNVAAGTWSTAPTDTSYEAESGTISGGSQKLSCSGCSGGTSVGYLGGSSGGALTINNIVTDITGLTTVRIRYANGDSTQRFADVTVNGVKQRVAFVPSGGGQMVFTASFTAGLVKGSGNTMKIEGVNGGWAPDVDVVIVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0F0</accession>
    <name>U4L0F0_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_07272</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935362">
        <property type="protein sequence ID" value="CCX07683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="15138" checksum="F1829DA2B5E81F05" modified="2013-12-11" version="1">MPEGWAKPRSKKDLKMNHLSGLVSEVRTRVADVGIWGKLSSVFPVGAARSIESPVSWMWMRRIHIGASTAQETERWTDKQSRKLKSKAVMMAGGAGAFPGFTTLRYASSLRHRYAGQNGYTVPQTYPVEDNWLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0R6</accession>
    <name>U4L0R6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935376">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="28060" checksum="8646773223D8AB9F" modified="2013-12-11" version="1">MVPTISISKRDPMDLRWPQWLQHGYKQLTGNDIVDNIDTSEISNSIDETNVTGNVDAEPISDNDILPGWPHDGDNCDEDMPTFTKQGAEENDNEDMPTFTNHVAEGKDNENMPHIPTPEDVAEYEIVKRDASAWEWPSFIKTPYAKWMASKMPDFVTDIAPSIGDVEDDEAEEPAKSLNNLAGDKMAENEVKKADKKKDEQEKEKKKEEKEKKEKKEKKDRKDKKDKKSNKKKNDEDEETHPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L172</accession>
    <name>U4L172_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="48" mass="5548" checksum="A58AB10BD5D814D7" modified="2013-12-11" version="1">MCQKWPSGFWITLASFLEYGHHATRRGSIEYGQPKVLISTLLVQNNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1C3</accession>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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            <end position="163"/>
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            <begin position="36"/>
            <end position="45"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="29576" checksum="D2445163362C57FB" modified="2013-12-11" version="1">MHIPRHTPGLSFSGRFSRRHTSSSYSSSNDGDNDDIWSTTATAGGSRSRFSRRQSSSSSSSPSASSTSSKSSTSSSSTSSSSTSSSDDDSSDDLWSTAATAGRGKKNRKPSPSSPSSDILDYCPVCDSYEPRSGHDPRKAKSQPIMGRRNSLPNTNDGSRKVRFEQETVRREVDRNIHSVPESWPSSVYYLGDPWTIPLSRGNRGTGSRCLPLVERERRVLKERVKECRLYGNGHCECWERVTVNVPGRLRRVRSFWGDGVVKVSVATA</sequence>
</entry>
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    <accession>U4L1V1</accession>
    <name>U4L1V1_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C1A6.01c acc. no. O13855</fullName>
        </submittedName>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
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        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="246"/>
            <end position="297"/>
        </location>
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        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
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        <location>
            <begin position="426"/>
            <end position="474"/>
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        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
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            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX08596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="543" mass="59227" checksum="E9981B44CD85332B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L212</accession>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="17146" checksum="68209CEA8FCB6395" modified="2013-12-11" version="1">MAPPPFSTTLTDNQTITLQSQESSHYTQATSRPPVRASRIVKTPTHQIIRSILQRLPDFSTEEELHRFLFSSEENLGANGISIILHLHKHQHWLSYDSEARYRKVPIMKIVHAMEANWETENQVKRFQSMEERCKAFFAAVEEVEGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L249</accession>
    <name>U4L249_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05930</name>
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    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21508" checksum="49F6118E27BAACFA" modified="2013-12-11" version="1">MQLPHLLVYITAFIGLASAVPSPQRKYSRISDLSDPAVQAELARATFCCDGTVITSACKERGINTLCGLRGAVPEIAFQTPRGSTKVVRRSEGNESDESDEAKEADVASSILNSRRIDWPHSSNMPQPTGNPQYPGFPPGWEPPTVSTSACLWGKQECWYINAEITCCSGSCLRQANGDSVCLPRVMAPRYRLGEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2I5</accession>
    <name>U4L2I5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Transcriptional coactivator HFI1/ADA1 acc. no. Q12060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_09054</name>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 100304</strain>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>U4L4C4</accession>
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    </evidence>
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</entry>
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    <accession>U4L4W8</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="698" mass="77663" checksum="A24251551C5137F3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7S5</accession>
    <name>U4L7S5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to WD repeat-containing protein slp1 acc. no. P78972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7S5"/>
    <dbReference type="STRING" id="1076935.U4L7S5"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CSGACLN"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="240"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="559" mass="60902" checksum="BD762A33DB0A289F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L866</accession>
    <name>U4L866_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_05921</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L866"/>
    <dbReference type="STRING" id="1076935.U4L866"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX06334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14022" checksum="DA2E2DF13AF613B6" modified="2013-12-11" version="1">MSSGGKGGKAASGKPSQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKSGKGGKAGASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L868</accession>
    <name>U4L868_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L868"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="144" mass="15565" checksum="C7753076B41D2BC9" modified="2013-12-11" version="1">MDKIKKEFHLEALAYTGLYDLNFDRLTRFATVAPKEDALASPRSQTYNTFLDFFAQHRAHFDNNVDAALTAFATRYEVNVAVYDNGAPAMPATPAILDAPAAPAALDVAATTNAQVIPDLEAPAGRMLLVTLPAPSRHGAMMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8L7</accession>
    <name>U4L8L7_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8L7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="275" mass="31646" checksum="D9CAE3A3F997E172" modified="2013-12-11" version="1">MGQDFSRVQIVEDIDPDQEGEPDCTPYIEYQKRRTDEMGKRFDENIRKNIKLFRDISDAASNSNTSRSNDDIIKLEQRVNDAIRKVWFYTLCDAFTKDLDPTKNALAISDIKEKTYGYWPNPSLRVLLRSPPGVNPPIDQDIVMFYNYSIFAKGVPSTGDISKDNAILLLEKKKGHFVIITIGLFAKIYYRQVEVAQPNMNSSGSVKLTLFIGLDEQDSFTDNILHLENVEDKNYISFKLKEMTRILPMTNVDEFTKLKRVNTSEDDAIIMSFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8M2</accession>
    <name>U4L8M2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8M2"/>
    <dbReference type="OrthoDB" id="10438540at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22520" checksum="EE20EEB736CFCC50" modified="2013-12-11" version="1">MSRRSHMQRRSSYSSNRSSSASDDYTSETETEHAEYNTYSNPIRVNRTVAITVEVSTKSSSDHDKDPEPTRVRTFCYSPTSISPTEGLRGGKMQFGPDSLTPRISDYTYNPYQPTYHLGVLVNKGADLSTAMSTYDSTASHEIDMDMDCYSKEELTAEEGILNGRVENAAYRSAPNKKKIARERISREDQFRASRRGLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L951</accession>
    <name>U4L951_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935511">
        <property type="protein sequence ID" value="CCX10096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L951"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="84" mass="9440" checksum="3DE747E940C3D546" modified="2013-12-11" version="1">MLTNIRIEAHIDDVLDNDAVLAAWDSDIQNKIRSTLKFKACGIERVHAAAEEQPVAFPMVNMETCNNRQPITFFRAGLSGFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L985</accession>
    <name>U4L985_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936105">
        <property type="protein sequence ID" value="CCX14977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L985"/>
    <dbReference type="OrthoDB" id="5428817at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="346" mass="37068" checksum="B09B9763DEC21BE5" modified="2013-12-11" version="1">MSPTNPPPSSTQQQFAALANLHTHYRQLLNTERAALHLERQLWEQERSVYLSRIAELEGSTPPVFKNPNPFSPPPTANPENLEDDDVAPPTAGGVEVEQDLAEGVAEGVAPEQNVALEDENPEDSNPSPEVPPPTGEQIRSHLSAAAAQSETSQPWQPPPPSLPEPAVLVADSAQQHGFPPPSISPPNPSPPRIITDPRLSISQHLPMISENRRASISLPPAAEEGEEEDDDDDCGSISSQEMAALLKEATRIVYPLSHSRPRGQSLADPSAGQRPLGGMRPGGRGPGLEGLPRFAGARDDEEEGPLKQEPVVELRLKKTSNFGFEFGDGGKWGAGFGGGGEGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9F3</accession>
    <name>U4L9F3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935315">
        <property type="protein sequence ID" value="CCX06814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9F3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="3130" checksum="7C4A24D1AD7806F1" modified="2013-12-11" version="1">MHHKQDFIQTARYFSSQPPTAPPPFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9N1</accession>
    <name>U4L9N1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to period circadian protein [Aspergillus niger CBS 513.88] acc. no. XP_001401130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935320">
        <property type="protein sequence ID" value="CCX06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9N1"/>
    <dbReference type="STRING" id="1076935.U4L9N1"/>
    <dbReference type="eggNOG" id="ENOG502S5EQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DSHMANK"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="382" mass="38660" checksum="3FADAF3C66408553" modified="2013-12-11" version="1">MSNTAGPHASDVANKMDPRVDSDLDGSRNAGLRRDDNFGSTTAGPHSSNVANKLDPTVDSDRDGSRNLGARDTTLGSGTTTGYGGSTNVGPHASNIGNKMDPRIDSDRDHRGTHTTSGAFGSSHTAGSTNVGPHSSNLANKLDPRVDSDLDNRGTTGYTSTSGGHGSTTAGPHSSNVANKLDPRVDSDLDHRGTTTGTHTTGTHAGGIGSTARTTGTGTHTTTTGPHQSNIANKLDPRVDSDRDHRSTGTSGAFGSSHTAGSSGAAYVAPGPGHTTAATHGGSTLNAGHGTHTTGTHTTSGPHRSDAANKADPRVDSDRDHRANAGVHSTGPAPNTAGPHKSDLLNKLDPRVDSDLDGSKTVGGDKTFAGANTTSTTGTHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB08</accession>
    <name>U4LB08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Uncharacterized protein AN7484 acc. no. Q5AW46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB08"/>
    <dbReference type="STRING" id="1076935.U4LB08"/>
    <dbReference type="eggNOG" id="ENOG502S2TB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TVSADWE"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF3">
        <property type="entry name" value="FUCOSE-SPECIFIC LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="215" mass="24180" checksum="715AB3B2491E4FFD" modified="2013-12-11" version="1">MPPDSSNFRYFNTPADTPVPSWLGNFVLKAHCGTDLWRKPSRETFTAPVLYTSSPQHFFRAEVTVHIRLQSAFEWDQGGLVIFAGPTPVTTTSTALPSYDQPPAGKWVKAGIEYYDGRTTASSVSASSDGADWSLVELPHGVSELKVRFERVDQALWVWFDDGCEWKKLREVTWFFYGVDEKNVRIGVYASRPANFVSGGPLEELVVEFEGLEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBD5</accession>
    <name>U4LBD5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="HF935619">
        <property type="protein sequence ID" value="CCX11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBD5"/>
    <dbReference type="STRING" id="1076935.U4LBD5"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKCTIQP"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="98"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="280" mass="30661" checksum="B5F79881EE8CF2B0" modified="2013-12-11" version="1">MASLFLLIPASILGLIMVLSIFGTVFKSCRFYARILTAYVLLATCATYGVVASAALRIVGKASIAQWATARAMKTLGCPIMGIDFDVEGEELLDTRPAVFVSNHQSELDILFLGRAFPKHCSVTAKKSLKYLPFLGWFMALSGTVFIDRANRQTALKAFDGAVKEIKSNKQSVWIFPEGTRSYFGKPDLLPFKKGAFHLALQAGVPIVPVVVQNYAHVLHLQDRTFEPGTIKVKVLEPIPTKDLTPEDVEGLVTSTREAMLKEILAMGSPKPNGDLKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBG6</accession>
    <name>U4LBG6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBG6"/>
    <dbReference type="STRING" id="1076935.U4LBG6"/>
    <dbReference type="eggNOG" id="ENOG502S712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5417068at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="18569" checksum="98A4C541EE543C72" modified="2013-12-11" version="1">MTKRVTNHSSNKEWPSLSIYERCKIRLATQPLRGWDIGSAILIAARFASACGTTYKYPTFPLSPLQRYNTSTIPPPPSNLSTKTSNPLNLISEMPKDNHGNSYNVTGHGTNSQGNHYCSRDFSSSSGSAGGSSGYHYSNANGSYYYSNPNGSTYYNNGQGGSTYTSPPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC17</accession>
    <name>U4LC17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Probable catabolite repression protein creC acc. no. A2QVV2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935656">
        <property type="protein sequence ID" value="CCX11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC17"/>
    <dbReference type="STRING" id="1076935.U4LC17"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="576" mass="65681" checksum="0AA0C291ADA2EAE4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCP6</accession>
    <name>U4LCP6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCP6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="4850" checksum="7D71516B2AD197CF" modified="2013-12-11" version="1">MSVHDRNSNGTLSKPRSASACNGTLHSTITPSDIKNHRCSPLTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCU6</accession>
    <name>U4LCU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCU6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3693" checksum="547CD26768FABFDC" modified="2013-12-11" version="1">MRLRFSKSLDGLMLYLLVLGVASIYEEGSVAASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCU7</accession>
    <name>U4LCU7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Spindle pole body component alp6 acc. no. Q9USQ2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCU7"/>
    <dbReference type="STRING" id="1076935.U4LCU7"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSCGEND"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="248"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="557"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="923"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="938"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="976" mass="110154" checksum="F69066105B125485" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDC3</accession>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30114.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="223" mass="23499" checksum="FE69DDB0BA3CF93C" modified="2013-12-11" version="1">MADIVYTIGIVLAIILLLVFMRGVFVRKAQMAQLTNQRNQALLAAHMPDDRSGNPSTNPAVPGGRAARFVTRTGPDGERVAFVVVGGGWRDGGVGGIGNGRDYHQSGPQWPPAAAIPGRTSVEEQLPMYEAAPPTYDALYKNGPPQPGSGTIPVVQNDGGSSAANAMEEGRVQRDVLLVTRPEAAVVADGGHPTYPPAGSEVTPQQQGVTGRVWSRITRGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>U4LE15_PYROM</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="15" mass="1734" checksum="CFBC33CC39F0B390" modified="2013-12-11" version="1">MILQSQSFTQVLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEQ0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_09347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7567" checksum="D5A186E68B04430E" modified="2013-12-11" version="1">MSLINYYRSLHPRTRMLLGAGVIVYGTLGLYLSDVAEEKLGFTPTAEDKRKLDEIVPKIRTVERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEZ0</accession>
    <name>U4LEZ0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_09028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCX30689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LEZ0"/>
    <dbReference type="eggNOG" id="KOG1831">
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    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="624"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="818"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1925"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="980"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2282" mass="257944" checksum="28802A3EE859CE41" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF55</accession>
    <name>U4LF55_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Similar to Uba3-binding protein but1 acc. no. O42666</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_08697</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LF55"/>
    <dbReference type="eggNOG" id="ENOG502SFSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MESIGAC"/>
    <dbReference type="OrthoDB" id="5390017at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="27017" checksum="DA71A39948B213BD" modified="2013-12-11" version="1">MYSACPPPQFLRPATTDQQAMSVLSPAPISLSRKRSPAVAFDADATPPSSRPPSRTHTKRVRSLKHAQERPAWVLERANSTRVDSRIDGNMSVDVRYPNHSMAAVSVGKLLREGGFTVLCFLGMGGETTMESIGACTGLLEGLGATCYGVSLQAAHMGRAVPIIHDAQRTLTKNLGLLHPLGGGRVALDAIVVLDAESRARMVLPIGWGVRGASEDGANLWENVMGRVVRGVEWLRGEVVETAMEVDMLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFH1</accession>
    <name>U4LFH1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935891">
        <property type="protein sequence ID" value="CCX13883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="10565" checksum="51F103F796BE0C86" modified="2013-12-11" version="1">MLIAIPSPHLRISIPGKMSSLLKKMFKKSDAKKKEEPPKAPQPGPVAKRNDPDGHLWKVLERGSGSLPAEVVKKKQEDLVKREPDLTTPPGTPVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGI5</accession>
    <name>U4LGI5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to SCF-associated factor 1 acc. no. P38352</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGI5"/>
    <dbReference type="STRING" id="1076935.U4LGI5"/>
    <dbReference type="eggNOG" id="ENOG502QUVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DFRIAPQ"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="594" mass="64681" checksum="EDEF07EAEC221520" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGU8</accession>
    <name>U4LGU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936188">
        <property type="protein sequence ID" value="CCX15511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGU8"/>
    <dbReference type="STRING" id="1076935.U4LGU8"/>
    <dbReference type="OrthoDB" id="2890403at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="376" mass="38503" checksum="62EED0A849D6204C" modified="2013-12-11" version="1">MLHTVSGDVLLRRFLNRAEQWNMTLGRSLSPGGGMVFSEKTGLYGVYFGISAPGASGGKEVNGTQIKMLSIDSNSVTSAGASGARTKALTVSTLLSTSSSSSKPACVINTDIITSGNGSFESTCLDINNGLWMGDTNLAAKTVPGDVEGNFNKLARFPGEGELYVMAYLVGTGDGTSDSSSTSSAALGLANVGISLLSPANSLHISTLLTSASLSASETNLNPRVCPITSTQALVTYETFSNGRFLGTNLQILNASGEKIGSAKLMKGMRISGDIVSTGGNGQSAKLCWPYVMMPSGASDAAEPRVQFMCAVLGGGNTNNPPNIPPIKSGEPPATDSGRSPAPTGIPTQPTKVTSTPTTKATPTSETEKTTVIANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV0</accession>
    <name>U4LGV0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NAD-dependent protein deacetylase hst4 acc. no. Q5BE04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGV0"/>
    <dbReference type="STRING" id="1076935.U4LGV0"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="503" mass="53960" checksum="21B44E2A43CD6F4B" modified="2013-12-11" version="1">MSKDAAPAATAPAPKRQRSPPKPRETQFLDLPFRESTGQKAALDSLLKLLRKKKKIVVIAGAGISVNAGIPDFRGSDGLFATLKTSKNSGKDLFDASVYKDNFLTASFHDMVRDLHGLASRAQPTQFHHLLATLATEGRLLRLYSQNVDCIETRLEPLNTVVPLQTKGPWPRTIQVHGGLEKMNCQKCGWVGPLEPGLFIGAEPPDCPECKEMESIRGIAGKRSLGIGKLRPRIVLYNEFHPDADAIGAVSSADIKARPDAVIVVGTSLKVPGVKRIVSEMCKTVRDFRGGLCVWVNKNDPPPAKDYAFDLVIRGDCEELAVLMKAQPEEGSDQEMSSVESFIEIDAEEPCRDSSMLEVVIPTQLPSPALSAASSTLFRDSTTQAKPRKRAPAPTKVEKPPPKPRARKPASEKPPAKKKAAASKPPTVGLISNAFKATKAPTAAAAKAKAKAAEAKAAPVKMEPVVLIPESMFMGSSLSPPPSSIPSPITSTRSSIPVSSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHC7</accession>
    <name>U4LHC7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHC7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="7274" checksum="95449D393B4E05DD" modified="2013-12-11" version="1">MPPDYQFAAWFEGCYVELFKMWSTRVHDTIAYRTSPYLMRSPCVPIIKVSDEVRFHDDNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHT6</accession>
    <name>U4LHT6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LHT6"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYFERTY"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI54</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="261"/>
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            <end position="381"/>
        </location>
    </feature>
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    </feature>
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            <end position="576"/>
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            <end position="119"/>
        </location>
    </feature>
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            <end position="146"/>
        </location>
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        <source>
            <dbReference type="EMBL" id="CCX31212.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="576" mass="62057" checksum="7E91DBEFA999CBC6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIN2</accession>
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            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
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        <property type="term" value="C:spindle pole body"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="797"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="952"/>
            <end position="1040"/>
        </location>
    </feature>
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        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="570"/>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Gabaldon T."/>
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                <person name="Marcet-Houben M."/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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</entry>
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    <accession>U4LJK6</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="EMBL" id="CCX12666.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    <accession>U4LJR1</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJR1"/>
    <dbReference type="STRING" id="1076935.U4LJR1"/>
    <dbReference type="eggNOG" id="KOG4198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWKCGEN"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="600" mass="64187" checksum="95DBA76CEC9BD902" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKG0</accession>
    <name>U4LKG0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4238 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKG0"/>
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    </dbReference>
    <dbReference type="OrthoDB" id="5340163at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="83462" checksum="A454AB4317CE05D2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKS7</accession>
    <name>U4LKS7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="HF935395">
        <property type="protein sequence ID" value="CCX29965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKS7"/>
    <dbReference type="STRING" id="1076935.U4LKS7"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTMFAYA"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651683" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="11">
        <location>
            <begin position="232"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="12">
        <location>
            <begin position="574"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX29965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="939" mass="102859" checksum="3A428E009D33C551" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLI3</accession>
    <name>U4LLI3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Late endosome and vacuole interface protein 10 acc. no. Q99382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_14014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLI3"/>
    <dbReference type="STRING" id="1076935.U4LLI3"/>
    <dbReference type="eggNOG" id="KOG3269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRPKYDA"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="175" mass="19717" checksum="59C2121F8C5210BC" modified="2013-12-11" version="1">MANKASKSLARQNSATLNRTHLTTLCIHLIFILYRLLFRRGSIIKYILLSLPSLLIEFYLERLGRPVYRGTEMIKPGEDLAAKGLTEYLWDIVYSTWIVLGLVAVVGEWAWWAGLVVPAYAAYLAWGLYKGFMGGQMPGMPQMGGAEGQEQQGEKSKRQAKMEGRGDRGGKVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMR1</accession>
    <name>U4LMR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized RNA-binding protein C22E12.02 acc. no. Q10355</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMR1"/>
    <dbReference type="STRING" id="1076935.U4LMR1"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTAFQPR"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="31461" checksum="87430FB2A576DD3E" modified="2013-12-11" version="1">MSYPPPPGTNNSLPPRPPPTMNSFARFAPRQVASTPHLSAPPQHTYAAPAVPAADYSYQAPTAYPGYAAPAPAAYSAAPSASAAPHIVNPFPLPGQRKTGDSRYADLDPELQAQIAQQQSIYDPSNAENLKARNAPRPATVEAGPKNAAAAKVPTVVRQGGGQTWTDSTLLEWDPSHFRLFVGNLAGEVTDDSLLKAFSKYPSVKKARVVRDKRTTKSKGYGFVAFADGDEYFRAAREMQGKYIGSHPVLLKRSNTEIKPVVVGGNKTKGGRIDKNKNKKNKGKNAETRKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNH0</accession>
    <name>U4LNH0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized GTP-binding protein YGR210C acc. no. P42942</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_14177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNH0"/>
    <dbReference type="STRING" id="1076935.U4LNH0"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WILGNLM"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000030">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="415" mass="44842" checksum="7525290BDE0AC39F" modified="2013-12-11" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDASSKVGTSFTTIDPQRAIGYLQIDCACARVGKQENCKPNYGGCKAGKRSVPIELLDVAGLVPGAHEGRGLGNKFLDDLRHADALVHVVDVSGTTDAEGKATRGYDPSSDIVWLRGEIVRWIQGNLMEKWGSIRRRHIALKANAVDTLQGQFSGYGSTSAVVARCLDKLGLKQPLEDWDNATIERVVNAFTDEKFPTVIALNKIDHPDADQNIAKIAKKQDPESIVLTSAMSEVFLRKLAKQGYVRYEEGSEFVDTRDDLIEDGDPEGGGLKEMDDKLKQRIENLKDMVLYRFGSTGVVEVLSRAAKLLGLVPVFPVRNIHSFGSGAAGNTAVFRDCVLVGKGSTVRDAAKKIMGDVTIAYIEGIGGVRVAEDELVEVGKNDILSFKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNJ7</accession>
    <name>U4LNJ7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNJ7"/>
    <dbReference type="STRING" id="1076935.U4LNJ7"/>
    <dbReference type="eggNOG" id="ENOG502QVPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEWVINK"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002646">
        <property type="entry name" value="PRK02318.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002647">
        <property type="entry name" value="PRK02318.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002650">
        <property type="entry name" value="PRK02318.2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="208"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="387" mass="42709" checksum="4260B32849BE3219" modified="2013-12-11" version="1">MKTALHFGAGNIGRGFIGALLSDSGYHVVFADVVEKLINALNEYKSYNITILDVAPDEPIKHISNVSGIFSNNPEQLNAAILDAEIITTAVGPNVLRIISRSLAAGISERKKQGKEYLNIIACENMTGASGHLRDEILKHLPEEDQEYMDTYVGFPNCAVDRIVPPFNPGPNGNVLSVGVEAFFEWIVEEPAFKGPRPEIKGMKLTDNLVAYVQRKLFTLNCGHATTAYLGYLKGYKTVDEALKDKSIESTVHAAMKESGAALCKKHGFDEEEHGKYIEKIMNRFRNPYIKDDVARVGREPLRKLGPADRLVGPAKMADEFGLPKDNLLKAIAACLLYDNKDDPQSVTLKKDIESKGLEEVLEDVVGFKKGSKESRQVLQAYNELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPY0</accession>
    <name>U4LPY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Aminoglycoside 3&amp;apos acc. no. P13250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936505">
        <property type="protein sequence ID" value="CCX16725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPY0"/>
    <dbReference type="STRING" id="1076935.U4LPY0"/>
    <dbReference type="eggNOG" id="ENOG502SP8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSAKMES"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="345" mass="38635" checksum="6087C6B6494CD9C1" modified="2013-12-11" version="1">MPPSRDPSTPAPASEEPGSPHPPTAAASSPSTTWSILPSFKTYESGVSLLARSCSRRTWSLGTDVIMKESPYDSPSETPFDEQDIVDFLSSNTNIPVNSIIAEWTDDNATHFIIKEKLPGESLQSLWPTMSWEEKGKIADQVAEMLRELRKLTSDKMERVKEMPFCDQMLFNHLHPHLVGPLENDQQLWAKMVESLKGVIPAPASRTLGRMMPPCQPYTFTHGDLSMGNIIVDKGKVTGIIDWEWSFFAPVWWEYVKFRAGTPRWIDPEWFELLDERMDQHPAAVEFYSKFQSLVSKVESHDPKKIRSGHALIQELMADDEENLGGSSGSNTAEGGTPISTHSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ01</accession>
    <name>U4LQ01_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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    <dbReference type="OrthoDB" id="38531at2759"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="715"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="498"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="881" mass="99216" checksum="C9CB107C534882C1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR52</accession>
    <name>U4LR52_PYROM</name>
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        <recommendedName>
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        </recommendedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:29969"/>
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            <dbReference type="ChEBI" id="CHEBI:61930"/>
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            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
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            <end position="55"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
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        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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        <location>
            <position position="260"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="356" mass="40303" checksum="30B344FE50758AC9" modified="2013-12-11" version="1">MGQEASTESFDPSIPPRKLAGRNLAAIAEYIKKCEKVVFMVGAGISTAAGIPDFRSPETGLYSNLARLELPRPEAVFDICYFREDPRPFYALAQELWPGKYKPTLTHIFMRMFSTHSKLLRVFTQNIDTLELAAGIPREQIVFAHGSFAGQHCIECKKEYDRVELEDHVRKAEPAFCECGGLVKPDITFFGEALPAEFHESLDLVEEADLVVVMGSSLSVYPFAALPQRVLDDTPRLLINMEKVGEIGSRREDVVWLGECDDGVRELAENLGWWEEMEAIWKESRGDMDLAEPVLNDDTLEDEVNRLTKQVADVLNVADEHNKRVLTKLQQEQKKAEEKKEVAEEKVEAEVEEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRA9</accession>
    <name>U4LRA9_PYROM</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38922" checksum="70E5809077126D3A" modified="2013-12-11" version="1">MTTLTDCPDLVLYEIFTHLDGFNSAARLARICRTIFSFWKGWEKCICRRLLQSAPRIVGQTNRRFIYNLGNEVVQLLDAQHERQTGLIHKRKRFAEMVAKRAGDLRTIRLISQQSQEIVKHGKNQDLDNNHYQIQWCVKRNIGRSRRRRLIFNCGRIELPAYEERNNFDEFYPMSIDIERAWKEHGMYIIQKGLYQLWMRSLLPKDPRSPFPSLEQDPAASNEMAHCLLQQRDENQVQLFGVVYLGNLHGYLTSVCGFPNMRRCVDFRALKGVTIRQRTGQALIETASKAACPNRLEGFDVILQPDEVCGESKLDEWEKLDMAFGWAFHPREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSA8</accession>
    <name>U4LSA8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein PXR1 acc. no. A7TG30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSA8"/>
    <dbReference type="STRING" id="1076935.U4LSA8"/>
    <dbReference type="eggNOG" id="KOG2809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PCWDQSS"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="350" mass="39396" checksum="7537FBD109E4A095" modified="2013-12-11" version="1">MGLAGPKESKKIGKDPRNTFWSNDTSRFGHQYLANLGWTPGQTLGDSNSSYHKSGHITAASSTGVKIQVKDDNLGIGARKGAQEDECVGLLGLQGLLGRLNGNTEQVDRVQEMQDRKKNELIESKFGMRFVRGEVWVADDLTKLRERMLKDKAAREKAQKKLEAGDKEDSDEEDGGKRKKRKRDDVEEGEAKEKKKSSKKSKDKKKLKSEESDKNSRTLLEVRETKSKSKSASTSATTSEDELDSAARKRRKEERRLKREAKEARRKEKKEKKEKKKEKKERKQKKKKASSDSDSSSDSESEAEKTTTKTPTPAYNALNGRHAIRARFIAAKKSAMMDAASLNEIFMIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSF9</accession>
    <name>U4LSF9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Trichodiene synthase acc. no. Q6A1B7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935431">
        <property type="protein sequence ID" value="CCX30236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSF9"/>
    <dbReference type="eggNOG" id="ENOG502SQ3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SYYKEFC"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="389" mass="44039" checksum="24CADBE0EED8C620" modified="2013-12-11" version="1">MNPLPSAFSQVASGFTRADKIFRNLYPSLFASFAPTSMSPPPSPPPERAEITAPKTEIIPSPNRPLGVDIDGNLLRQFLASMDFDLTAPAIPRNRELESALLDVFTAENLPEKYIRHIEKMLLYTTAATEMSYFIHSFEFKVFIGTYITLLLFIDDLCERDPDSMVPYLRTFVAKLGSNSDISDQHPSLRHFQRLVTDDAPKFFGPIGCGMVMKSSIDYYLGCLLEAQFPDGVKCSSSCTRFPRFLRLKSGNSETFAHMIFPATEFPEDKYLEIYLPAIPDIIELTDMINDILSFYKESVIGTEKNTFFMVLAKANNVHPVDVLIQTGTRQGQLARDVRQTLSKCPELLKAFNTYLNGYTMYHCTQKRYKLWELGMEMICPGEEGQNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT72</accession>
    <name>U4LT72_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Subtilisin-like protease CPC735_015300 acc. no. C5PCX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT72"/>
    <dbReference type="STRING" id="1076935.U4LT72"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WIAQINE"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652359" evidence="8">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="153"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="402" mass="40925" checksum="8A959117DEC9CD75" modified="2013-12-11" version="1">MQFFKNIVLAAVALLPLTGVLAAPAAISQLKDGDVIQGSYIVVLKSDASSADLQSHQAWAGRLHAEAKSKRASTSSGFKHTYEFGKLKGYSGEFDKATINEISTRPEVAFVEPDRVVKLAAQVTQANAPSWGLGRVSRRARGATSYVYDSSAGSGVTAYIIDTGIQITHNEFGGRARWGYNAIDTSNSDGNGHGTHVAGTVGGTNYGIAKLVNLVAVKVLDASGSGSYSAVIAGIQWATKDSAGKRAVANMSLGGTYSAAVNSAVTEAVNAGISFVVAAGNSNTNAGNTSPASTPTAITVGATDNTDSRASYSNYGSVLDVFAPGSSITSSWIGSNSATNTISGTSMASPHVCGMAAYLISKEGLSSPAAVTSRIIALASTGYVANAGSGSPNRLLYNGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTA1</accession>
    <name>U4LTA1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Uncharacterized mitochondrial carrier C29A3.11c acc. no. O59674</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTA1"/>
    <dbReference type="STRING" id="1076935.U4LTA1"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRRMYRG"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="133"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="242"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="332" mass="37416" checksum="AAF645AD18B3B190" modified="2013-12-11" version="1">MPDSHDVSMTNTILTSNRILSPGQQYAKKYRTEIAASASSCVSTFIAFPLDSVKTRMQAYKFRSFWDCVTQTKQNEGMRGFWRGSLAPLVSVTVVRTISFSIYSKSKSIYAGMLKPVFGDKLISMPHAPFMPLNPMYWFMSGATAGGLITFIACPFEFTKLSAQIELLMQRSRRSSLDDPSHIRQYKRKGTFGQAVDIVKSRGPLGLYSGFHYHFLRDSLGTAMYFTFYEGGKAFLSPPEGPNTLGVAVSGGLCGLLSWVLIYPIDSMKSIYQRDILTHQPGQPLPVRPIQLFNRRMYRGLGVSMLRSCILNSVFFSSYEHIKRRINDFVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTQ8</accession>
    <name>U4LTQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Pisatin demethylase acc. no. P38364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_09677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX31001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTQ8"/>
    <dbReference type="STRING" id="1076935.U4LTQ8"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIAMMEV"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF85">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="520" mass="59265" checksum="1AB7A90362CD03C1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTT0</accession>
    <name>U4LTT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTT0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6640" checksum="9AF4A18BCDBFF929" modified="2013-12-11" version="1">MIQLWLRKSPRPIDNGECHKLQRKSSLIVCANYVLALCSPSTFSSLSSLCLAFASRVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTU6</accession>
    <name>U4LTU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936022">
        <property type="protein sequence ID" value="CCX33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTU6"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9127" checksum="9F8E5F059F7BB109" modified="2013-12-11" version="1">MLNAVLITNDKRTMETDAAKKMTVLKAEEARWEEIAGTYLMDYGSASIAPGTANRLMVRGVNDFIIPAAAGDASDKCTNISTASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTU8</accession>
    <name>U4LTU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936022">
        <property type="protein sequence ID" value="CCX33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTU8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2488" checksum="62744654C5F91BDE" modified="2013-12-11" version="1">MFRIESIWLWRVNIGYGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVF5</accession>
    <name>U4LVF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVF5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11751" checksum="B48DD8C5D33692B8" modified="2013-12-11" version="1">MNGRDSSVVCLHPDATELRKFAGAVMCCDDRPELGGGAIDGRRIRCRSPDARRRDLRKLPASAGICERKLMTEQPRRSEIQQKESSGWYRFGKASVQASVEDNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVR9</accession>
    <name>U4LVR9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVR9"/>
    <dbReference type="STRING" id="1076935.U4LVR9"/>
    <dbReference type="eggNOG" id="KOG4414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LRAVWQT"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="215" mass="24183" checksum="1361D0C14C04C75E" modified="2013-12-11" version="1">MSDLSQPQFTLEYLSALSAAGIHPATLVDVLSEFESELHIETNTRPSAPELFSAFFTIYLLSLILEHDLNEARFLLQRIPQTRQKDPQIETATKLVKALYTRSYPEIYATLALPEWSAAAIPLVNRVEQDFKKSTFSLLSKAYTTITPGSVNLYLGLDTPEEETIKNLVSEGWSYDAERKLLKPSVKYNSGVSRVGQMDDRIERLTSLVTHLADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW09</accession>
    <name>U4LW09_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to GTP-binding protein rhoC acc. no. Q96WY0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_14070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW09"/>
    <dbReference type="STRING" id="1076935.U4LW09"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTKRTCI"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="26761" checksum="8789B42F641E89B3" modified="2013-12-11" version="1">MKSSTISSTLSNSRTSTPISMDSAHSTLNTRSTGLSTPAPVAAYSKKLVVVGDGGCGKTCLLIAYSQGIFPEKYVPTVFENYIAHKLHPGSGKTVELALWDTAGQEEYDRLRPLSYPETDVLFVCFAVDSPHSLENVLDKWYPEVLHFCPHTPVVLVGLKTDLRKNRNVIELLRTHGMTPVSVEQGRDVAKRMNATYSECSSKEMNGVNELFDLAMDMAIGVNGKGPAPGIGGKRKKKKKDCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWF0</accession>
    <name>U4LWF0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pc21g21910 [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002569162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWF0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="126" mass="14548" checksum="F7A35037AC488430" modified="2013-12-11" version="1">MEKIDLSHFENSNISHVRDKFQLKKEGDYISERLGKANTKRRQLLTYNENHHEKLVGRRPDDMRAERNDSDFDGKGKGNDRDLQSDSAEDVLGFGQKDYMSQTASRSWGTTASTVHEEGFTIIFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWI0</accession>
    <name>U4LWI0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Protein GMH1 homolog acc. no. P87155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWI0"/>
    <dbReference type="STRING" id="1076935.U4LWI0"/>
    <dbReference type="eggNOG" id="KOG3012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YRNFMYR"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="269" mass="30866" checksum="1FD28600D811AFEA" modified="2013-12-11" version="1">MASRYSPPPSRAGFPHITAPRYTSAGARAERSTMRLPVFFKRIWKYPQMDFEMAIWEMINLIIAPKKVFRSIYYHKQTKNSWSRDDPSFIVLLTFFLTLTAIAWGLAYTPSFASIVRLVFSLVFLHFLATSLICATAGYYLCGKFLKVPQQGGLGRAGIVAGGGDLEFMYCFEIGVRAFFPVWVFLYVIQYFMMPLLSQNYWISKFVGNSLYLIAFTFYSVITFLGYNALPFLHHTEVILFPIIILVVLWAVSLLGFNVAKHVVELWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXW9</accession>
    <name>U4LXW9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936586">
        <property type="protein sequence ID" value="CCX34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXW9"/>
    <dbReference type="eggNOG" id="ENOG502S4VS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="7990" checksum="B7724F28DFE21C1B" modified="2013-12-11" version="1">MLAWVKEHPFYTAFIVLGLILDINPFAATGFGALGPQAGTFAAAWQSHIGATVAKGSSFALLLKLGMVGANTIPAAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTS6</accession>
    <name>U4KTS6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTS6"/>
    <dbReference type="OrthoDB" id="5475763at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="322" mass="37242" checksum="ED301E4C5EB8E05B" modified="2013-12-11" version="1">MRISMPGSTLIPSPNGSGNRLLDSYAMDDISQSITPLNPSAFEIVSYFDYPEKLTSFIVSATITGGKRETRERKFSDSTVIRSIRTTQTIRNVETSRTTETNRTALPVRKGLIDIVSDEPRPEIVSVVHMHGYQPFAVGDPNLQYADPFAFIHESTMRDAMYLTPGVPAETDISIKRLVDKRLPLPQESEKKKSLIKLPELKLPAIDVEQLPKKIPKKWQRYLTMSREKRTLCKELDERWESLLKRTEEYQIHVKLVDREYNIVSSSFPKTKLIRDCGKDLIDTKGKFEKFRGYVLGRTRIFYNSDWEFDRPDFETRRINDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU37</accession>
    <name>U4KU37_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU37"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11712" checksum="2EEA9584A4A4DEB1" modified="2013-12-11" version="1">MDPLTLASISESSRTNKDLNNNTDKLEPFYNLSQGDMKEHAQSKKAAKGKWAKIKNLIAAGKKSKKEIYVEHGIGIEDEKEMDSFFGSDQWRTKKSAALEADDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUD4</accession>
    <name>U4KUD4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Acyl-CoA-binding protein homolog acc. no. P31824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935198">
        <property type="protein sequence ID" value="CCX04321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUD4"/>
    <dbReference type="STRING" id="1076935.U4KUD4"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYKFEAW"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10151" checksum="82A7551FC74B8A6F" modified="2013-12-11" version="1">MPSEGSAEFQAAAAKIQQLQKMPDTETLKEIYALFKQVTVGDVTPADKPGFTDFQGKAKYAAREKIKGMSAEEAEQKYIAIVDRLVAEIGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUH6</accession>
    <name>U4KUH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein NipSnap homolog 2 acc. no. Q9PU58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUH6"/>
    <dbReference type="STRING" id="1076935.U4KUH6"/>
    <dbReference type="eggNOG" id="KOG2883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REKSWSV"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="145"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="224"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="323" mass="37184" checksum="02CE04ACBF8A39FF" modified="2013-12-11" version="1">MFTTTTSARQLRLGLRSISTTRMLKNKLPALGDIVHTPENSAGYKERLRAFRAKLEEQKKAQFAALHGKSYDDEPKAGIVKSILYGSEKGQREDAELEQSYSKVLARGKYVHAIEIHNVKPDKQQEYSDLVGNMYPDIANDPNNSCHLVGSWKTEIGDPDTFIHIWEYKGYAGYHDTLNQLQNSAKYRDYSKKLPQLLYARRTDLMQEFSFWPTTSPRSLGGIFELRSYTLHPGNLLEWETHWRAGLAARRNVMEGVGAWFTQVGALNMVHYLWQFQDLRDRQLAREHSWSEQGWSSTVHKTVPLIQKMESRILVPLPWSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV66</accession>
    <name>U4KV66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV66"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="402" mass="43918" checksum="8FCA67EC6B6D22AF" modified="2013-12-11" version="1">MMGQYVEGLQQPSRAEPSETYQKPPQPICVPPALPITKKEMVHSYPEAQEQQARVVASNAHSFTTAPPDVDSHSPPQASAGSSNPPPAPIKEQTQRLQKDLPEHIVTSNTHGSNARDLGSIGILQATPKANATMMPLRVLEEQVQARGLDTGSTAGAPSSLLCKPANSKSRDEIKSLYPEEHNAQTQGECYESNPHRAKSASSDSNCVRPVPPERIEATLPPYSEAQDETHPMRLNTEPIASASSPVVSIPVTSDMEEEMVPRCPDEQERQEPVYEDSDTESISSASSAVDSGPATPTDMQMPRMYPDIDLITSVEQPEVRNFGAEIVAIHSQEKKIRFKDDYGKLEPIKGSSSSMYPPSEYPSVEDLGLMYNHRGQEVIDPTLLGQKVRLAGQHMSGIWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVC9</accession>
    <name>U4KVC9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_04799</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVC9"/>
    <dbReference type="STRING" id="1076935.U4KVC9"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFNKAMH"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="14">
        <location>
            <begin position="83"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX05212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="381" mass="42627" checksum="B6E66B0943412764" modified="2013-12-11" version="1">MAVNKVQLEREDHERDAAFKQAMHGKTAAQDAGFMAMLKKNKEGQQMAVDEYFKFWDGKGAGQETDADMKERVESYATLTRHYYNLATDLYENGWGQSFHFCRFYPGEGFYQAIARHEHFLAHMMGLKEGMTVLDVGCGVGGPAREMTRFAGVNIVGLNNNDYQIERATNYAIKAGLQDKQKFVKGDFMQMSFEPNSFDAVYAIEATVHAPSLEGVYSEIFKVLKPGGVFGVYEWLMTDDYDPNNAKHREICHGIEIGDGISQMVKISEGLRAIKAAGFELEYHEDLAQRPDVIPWYYPLAGDLKHVRSLSDLFTVFRMTKLGRSAVHKFVGGLEMLGVAPKGTQKTADTLAVAADCLVAGAKENLFTPMYMMIARKPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVY2</accession>
    <name>U4KVY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVY2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="254" mass="28774" checksum="341912C0D0647F39" modified="2013-12-11" version="1">MSTLTKFTIESFIFTLKSSFKLPSIFRSNGKVKPEPIDEDIELFEPHPQEPGILVRKSDRRRFRKAGSYHGTYNNAERNQDQQLSTSRNHSYSEVYSRYVAEHGSNYSIYAEREIFERLMIAGGSGGSDGSAGTNTADSDMKRKRGVREKLAVKTPFSTVEEETASEISEDNRRAEVEADRIRDQYLVEEKNFGDSVPEWLDSLEEADKSDVIMGVKVSMEDLVWDSVVEAYSLVPPKGVISPLVEVRMLNDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW00</accession>
    <name>U4KW00_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW00"/>
    <dbReference type="OrthoDB" id="5487549at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="175" mass="19716" checksum="12E8352F7D61E7E9" modified="2013-12-11" version="1">MVQVHQLATPHSPTPTANSGDQTMEPKSSADATVNPKQDTQHSSAFTHLAEMLTVAMDWPKNAQNFQQQIDQLTKEKDLLVKENDRLVLGHHQLEEKNNQHTEGNKQLAKENGQLKEQLATVNEQPNTPETQKLIDRLTIENGQLKEAREAAIEQFKAQPIVQGMINKLVEEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWQ2</accession>
    <name>U4KWQ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_05228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935262">
        <property type="protein sequence ID" value="CCX05641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KWQ2"/>
    <dbReference type="eggNOG" id="KOG1808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ILEQWHR"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="6"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="4781"/>
            <end position="4982"/>
        </location>
    </feature>
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        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="4128"/>
            <end position="4684"/>
        </location>
    </feature>
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        <location>
            <begin position="2832"/>
            <end position="2859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="4140"/>
            <end position="4149"/>
        </location>
    </feature>
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            <begin position="4150"/>
            <end position="4160"/>
        </location>
    </feature>
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            <end position="4198"/>
        </location>
    </feature>
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            <begin position="4207"/>
            <end position="4236"/>
        </location>
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            <begin position="4252"/>
            <end position="4280"/>
        </location>
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            <begin position="4286"/>
            <end position="4301"/>
        </location>
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        </location>
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            <end position="4377"/>
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        </location>
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        </location>
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        <location>
            <begin position="4435"/>
            <end position="4447"/>
        </location>
    </feature>
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        <location>
            <begin position="4476"/>
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        </location>
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            <end position="4502"/>
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            <end position="4541"/>
        </location>
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    </feature>
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        <location>
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        </location>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX05641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="4985" mass="555235" checksum="9312C539D4AEED83" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWT7</accession>
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        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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            <end position="368"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="408" mass="46372" checksum="1597A9A1BD63FADE" modified="2013-12-11" version="1">MDPMEEVFKDIPKSMLSHLSKVVLQPSHTFIKIFKKDWDEHFPRREVDGKKAFHYLEGKLEPEEIIRLGQDALQFIEEWYHHRLNVFTPVGTDKYRRFKRERLMQDKAIYDEVGALKQSERLDFQRAVILLNREFRSPILDQVIFDAYIAGGSDEAGGNSSRIIKKPSRPVTWASLHETDMNPGLIDQTLIPRSGSHSMLPAQYTFAPGAFKEQAKSVQAVSQGTHGLPGYNFSTTSGEIAKVEYHQFTNGITIRTIGGGEVAFCVEVSKDKWLCTACAKEYKSQPICARHVKEHTNGKVECPFVATGRCGKATLFSRYDKIREHAEVHHPEVSLDDPIMAAVYTLLRRGERSKPGSLKQNRASSMSTYKPDMSALVDDDSMDLDMVDYYESEGEDNEHFDNEDDNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWW4</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="9941" checksum="5BF4F60E2F1E260B" modified="2013-12-11" version="1">MLSIGRIVRFSNPWKTELEQAFQSRAVCVLVKFEKGEVVAPTALRGLKNWEVGTILRPELNYVYGSILGQYQNTRNPNRLEGASMQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX70</accession>
    <name>U4KX70_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Bifunctional xylanase/deacetylase acc. no. P54865</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935287">
        <property type="protein sequence ID" value="CCX06376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX70"/>
    <dbReference type="STRING" id="1076935.U4KX70"/>
    <dbReference type="eggNOG" id="ENOG502S2CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSHADLC"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
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    </dbReference>
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        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
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    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651713" evidence="9">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="118"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX06376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="327" mass="35434" checksum="F83B71E92C1E488D" modified="2013-12-11" version="1">MVSVSSLLLALLPATSVLACAMHRATTTQDSVERRDSSTGQCGAANGNLSCNGTTVNRCCSQAGWCGDSTDHCGTGCQAAFGYCSPPAPAPTIPAISTRAKLGSVPYGSEIYACTKANTIALTFDDGPYLYTAALLDLLKTKGVKATFFVTGSNLDKGDIDSTAAWTSVIQRAYNEGHQIASHTWTHADLSAVDEATRKYEMVRNEQAFLKIIGKYPTYMRPPYISCNAACQATMGTLGYHVILWDLDTDDYNQDAAGLIQNSKNNVKTAYDQRWDAYMSIAHDIHYQTVYNLTSYQIDAGRAAGYTHTTLGECLQDPAANWYRTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXB0</accession>
    <name>U4KXB0_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05553</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX05966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="69" mass="8200" checksum="99F319ED9D4ACE2F" modified="2013-12-11" version="1">MEQLKAQAVLQTMIVKLVMEKKDLKEQLYAQNENPESTTEMEKRIQKLEKENDQLKRQLLQLLAIKEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXQ5</accession>
    <name>U4KXQ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXQ5"/>
    <dbReference type="OrthoDB" id="10432573at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="35056" checksum="C73E9071BEB3879C" modified="2013-12-11" version="1">MVHSQWAQKMYNIAWNKAAQKLNEWTAEKTGEIEELRSVLSEAHYAINRFCHSKRLYQDIDYAKFDTFLQALRDFLPKCKDVYPGVFETYEVGVIMIERYGLDGQRLQPFWFHAIERSEQRNREMVADSDTILMTVPEFYKHRGYKEDDEETQRLFRDVIAFGEEFVRKVADDNDGVIESLELLFSENESLLKRVAIHCCVEERLFHPIYPIFLNGSVYIDLIGPHPVVAEGYTSLVQNDVNRLKDILKAKESGEMVQKGSDKRDDLKRKRVEDLDRDKDMVKLVKVVHGESMDEMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXT0</accession>
    <name>U4KXT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Poly(A) RNA polymerase cid14 acc. no. Q9UTN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935303">
        <property type="protein sequence ID" value="CCX06651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXT0"/>
    <dbReference type="STRING" id="1076935.U4KXT0"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="358"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="764" mass="86304" checksum="1FD07C8528E517EB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY24</accession>
    <name>U4KY24_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_02426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="HF935205">
        <property type="protein sequence ID" value="CCX04469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY24"/>
    <dbReference type="STRING" id="1076935.U4KY24"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GATCNQN"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX04469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="360" mass="41236" checksum="65533C14F2D51B37" modified="2013-12-11" version="1">MTATTTTTTTAQAGSGSHDWLWTYQEEPHRTRRMQIIKAHPEVTKLCGPEPLTKWTVLLVVSIQIAAAYAVRNTPVFSWPFFLTAYIIGATANQNLFLAIHEISHNLAFRSPAANRILAIFANLPIGIPYSASFRPYHLIHHKSLGVEGVDTDLPTKFEALFLDSILGKAFFCTFQILFYALRPMMIFQVAFTPVHAANIASQVFFDMVIVHYFGWNAFYYFIASSFLAGSLHPTAGHFISEHYVFEKTDKSPREKMSAVAAPETFSYYGPLNFFTYNVGLHNEHHDFPAIPWTRLHKLNEMAKEFYDPLPVHKSWTWIFVQFIFDGEISLWSRVKRENNKKVQAKWTKEEIEGEDVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYE3</accession>
    <name>U4KYE3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935346">
        <property type="protein sequence ID" value="CCX07252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYE3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="28" mass="3526" checksum="BF506F6B6AB4D4A2" modified="2013-12-11" version="1">MCMTANQRKENISNYNDLFLFFQLWRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ65</accession>
    <name>U4KZ65_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ65"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8262" checksum="05DF8110C5B88F05" modified="2013-12-11" version="1">MHVRFLMKKFSAKTQLGRCKPHITGSVAAGEINFGPASHTAVLTRQKGDYSRQNSSHMEHMGCGSDHSSEPPIGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ70</accession>
    <name>U4KZ70_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Transcriptional activator of proteases prtT acc. no. Q5B8L0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935330">
        <property type="protein sequence ID" value="CCX07010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ70"/>
    <dbReference type="STRING" id="1076935.U4KZ70"/>
    <dbReference type="eggNOG" id="ENOG502QW6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="283" mass="31401" checksum="7EF881B509A88C44" modified="2013-12-11" version="1">MDHHPQRPASTTSNTMKRSYDDANGSATSSVNGSPPSCDISPSYGRKRRSNSPPPIPNPLPPVPSVFTDAHGRIARIPTISRKVRACSACKKQKIRCDFDDGQTTCVRCKKMKLECVVNRSLQTILDEDVEWKHKMRDDTIQLQRAVGHLLSTLNMRPLAAYSPHSPPVSRTSSEPPGPKGPVAPNHHRGTSQPFPEHNSEHFKMEDDDHVRSAPMARDHSTHEEHEGQLFSNPMGSLYEVTKLRGLRGNDGERSGAPQEEIDMDFISRGLISLSEAQELFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ77</accession>
    <name>U4KZ77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935369">
        <property type="protein sequence ID" value="CCX07735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ77"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="121" mass="13583" checksum="825B07D85C41C2CC" modified="2013-12-11" version="1">MLGKSALMPHLPYSIMVSRELSALLYFCLGLPSKEVPGSVKLCIVQLRTRSHPNTNTEPRSMVQHLFIASECRMRLRLSRGVSGVLRSEYSNTNPVFLWKGLHLRTILACSPASHEIFNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZH2</accession>
    <name>U4KZH2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Phenol 2-monooxygenase acc. no. P15245</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZH2"/>
    <dbReference type="STRING" id="1076935.U4KZH2"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WEVAFWN"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="38"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="445"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="625" mass="69029" checksum="AD29CFF01BB6F600" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Y0</accession>
    <name>U4L0Y0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Heterokaryon incompatibility protein 6, OR allele acc. no. Q9UV10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Y0"/>
    <dbReference type="STRING" id="1076935.U4L0Y0"/>
    <dbReference type="eggNOG" id="ENOG502SPND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RKIWIDQ"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="77"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="840" mass="96898" checksum="0E4EAE69988663A4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L126</accession>
    <name>U4L126_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935421">
        <property type="protein sequence ID" value="CCX08587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L126"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="19533" checksum="B71D396970675A59" modified="2013-12-11" version="1">MPSDRSHLAPGCPKGLPRTILAVRQQIQDVSDELDTVITNLERTRRLSDVNLEYLHPNLPEYDSPEPSLTRRFRRQDRSSGNRLEYRRRPSSVDLEYLHPNLPEYDSPEPSPTRRSRRRDGNRLEYPRRPSSVNLEYLHPNLPERDRNKRTRTRPEIDKNTGLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L163</accession>
    <name>U4L163_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to conserved glutamic acid-rich protein [Aspergillus kawachii IFO 4308] acc. no. GAA86825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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</entry>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="HF935536">
        <property type="protein sequence ID" value="CCX10365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2W1"/>
    <dbReference type="STRING" id="1076935.U4L2W1"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="417"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX10365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="505" mass="55834" checksum="63DE3B81F2CC6F6E" modified="2013-12-11" version="1">MNILRRCLRVPGIRQYSTITEQAQRTDRPLRLAVIGAGPAGFYTSYRVLSKLTNAHVDMYESLPVPYGLVRFGVAPDHPEVKKCQEKFDEVASSDRFNYIGNIAIGTSSPNLPFNPLPLSHITPHYDAVLLSYGAAKDKKLGIDSEDTLKGVYSARAFVGWYNGLPEYAGFESQMLLDSAEEAVIIGQGNVALDVARILLTPVDDLRKTDITEQAIEALSKSRVRSVRVMGRRGPLQAAFTVKELRELLSIDGLGFGGVDPSFFPAELKTLPRTQKRVSEILQRGSKSPYVPGGKTWDLGFCRSPAAFLPSESDSTTLCAVRFEKTTLSDPIFSDKAKVTGTGEFVDVKAQMAFRSIGYLPESLPGFEEAGIPFNTKWCFIPNENGRVVKPAKDDGSAAERIPGVYTSGWVKRGPVGVIASTMFDAFETGDAIVEDWVAGREFMGGKEEKHGWEAVQSEVKNRGLRPVNWEEWQKIDKAERERGQKVGKEREKFVTYSDMLSVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4C6</accession>
    <name>U4L4C6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to GDSL esterase/lipase At1g29660 acc. no. Q9C7N5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4C6"/>
    <dbReference type="eggNOG" id="ENOG502RY46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KYFVIMN"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="295" mass="33221" checksum="2B80DC3BBD005375" modified="2013-12-11" version="1">MIANNGSYPPDGYISPDTAVTASGGRSWARYAAYYTGATLYNYAVSGAVCSNEITPRHTDWLHGNFPSVREYEVPQFTKDLKAGDVQVDWKNTVSALWIGTNDLGGDLLLGHSQVPGKTMVDYTRCVWEQLETLYKMGARKFVLINVASLELSPLYIAGGVPGPNRFWTLKGDNTTDISSRMIENIAAVNEIFSLRAETHKMKGAKVAILNANGLFRDIWHHPENYLNGTEPLNVKSWTNHCDINFENCWQEQPENRDAYMWFDELHPSEQVGRVIAKEFTKVVEGKKSAWATWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4W9</accession>
    <name>U4L4W9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_04677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="HF935234">
        <property type="protein sequence ID" value="CCX05090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4W9"/>
    <dbReference type="STRING" id="1076935.U4L4W9"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMNDFEC"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15609" checksum="CD5900C71097465B" modified="2013-12-11" version="1">MGRKTWLSIPPRFRPLPDRLNVVLSRDTSLDLGENVITATSFDDALQKLAERDVGRVYVIGGGEIYKTALQHPATENVLLTRIFSPFDCDTFFPALDGWEEAGREKLSEFVGERVEEGNQKEGDVEFKYELWQKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5B6</accession>
    <name>U4L5B6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935239">
        <property type="protein sequence ID" value="CCX05240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5B6"/>
    <dbReference type="OrthoDB" id="5483320at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="109" mass="11880" checksum="4AB31853B0666938" modified="2013-12-11" version="1">MKNDHKDNNKNKKAEALKLPVRETANQPAPKPDSPGPSPPPPPPSPAEEAILGSSSRPANAATTKPGSVNKKDLSGMSRYEKQRFWGWLCDEDGRVDVTHPAFTGFRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5J9</accession>
    <name>U4L5J9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935619">
        <property type="protein sequence ID" value="CCX11453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5J9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8673" checksum="7674C9D38E0CD3E8" modified="2013-12-11" version="1">MMEPRTAVRTIDLVRPVLNWAHQSFYNLDRPLRDCRHRRTVQSTGSSAQFDSTCDSRVLAALELLEVDRQVSLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5K1</accession>
    <name>U4L5K1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized WD repeat-containing protein C27B12.05 acc. no. O42996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5K1"/>
    <dbReference type="STRING" id="1076935.U4L5K1"/>
    <dbReference type="eggNOG" id="ENOG502S49J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADNIPNV"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="751" mass="84171" checksum="08BDAD2D053C2120" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5M8</accession>
    <name>U4L5M8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935700">
        <property type="protein sequence ID" value="CCX12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5M8"/>
    <dbReference type="STRING" id="1076935.U4L5M8"/>
    <dbReference type="eggNOG" id="ENOG502SPRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="24266" checksum="EF60E6D9A6393979" modified="2013-12-11" version="1">MRVINLRRLKCLKKTCQNSGTCLSRVKINFVNYRGIFRRYSMHSTLGVILLHRHFLLNQDEKLIEYPGVSTPWTVGISSSSIVGGRITPRCWSISSDKQLQPTEFRFVIPGDDLFEPDFPEDFIDDFYGFLLRRGLAALMGLTMFNATDAISGNREVERTIRRISVTIPVQEAQFEGVEAAWTFGCQENLSDSQFLNARVWWVCQECKPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L672</accession>
    <name>U4L672_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to GTP-binding protein ypt5 acc. no. P36586</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L672"/>
    <dbReference type="STRING" id="1076935.U4L672"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX07936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="215" mass="23386" checksum="DBE7017FFE7B2040" modified="2013-12-11" version="1">MSHPRASTQSQRFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTIALDETTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQSSSLDKAKAWVKELQRQANENIVIALAGNKLDIVTGDPSKRAVETVEAEAYAKEAGLLFFETSAKTAQNVKDLFTAIAKKLPLDQPGPRGARPGAGGRGVDLKGGMAAQQQGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L689</accession>
    <name>U4L689_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L689"/>
    <dbReference type="STRING" id="1076935.U4L689"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VKPYHNE"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="26308" checksum="9FE54B07DE400A8C" modified="2013-12-11" version="1">MPPASQTKRIKGISVFRPIVYGNSAQPVDPDNRPRGMPADHTHTWTVSFAGNDGQDITHFIKKVQFKLHADSYANPVRTIEQPPFEVTESGWGEFEIPIKIFFHPESNEKPLTMFHYLKLHPYIGTEAEMEQQRVQRKPITSYIYDELVFNEPTEAFYDVLTSKGNVRIPTKSSARGRGEFVRETEEMEVERIGEALRVVDEEVAKAKEKMKAKEKEIAEMQKALEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6F7</accession>
    <name>U4L6F7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6F7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="234" mass="26994" checksum="DE13A87198E403CC" modified="2013-12-11" version="1">MPLPQLDHNLRWQNNPNAKHFNDQEKALLDGLHEVSQSQPPLTKSAAGILLSRQLTLDTAISEREITLIPGHAPITSSGELHPEIFDYLYGDSDTARQVWHTMFCISHLYGANDKEFEWYLEREKELWLLDVEGPYLYRTLGAWWEDYNRLLLKIKRDLGRSYSQLVNKVSTGGLRAFNIDALEHILVISHSPKKERTKRLCRLSRKIEYSLRVAEKAGVVPITVVSDKFESRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6J5</accession>
    <name>U4L6J5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ankyrin repeat domain-containing protein 50 acc. no. Q9ULJ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6J5"/>
    <dbReference type="STRING" id="1076935.U4L6J5"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNPEKEI"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="255"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="546"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
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        <location>
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    <feature type="repeat" description="ANK" evidence="2">
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            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114448" checksum="E9121FEE405D1E5A" modified="2013-12-11" version="1"> </sequence>
</entry>
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        </submittedName>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="358" mass="40365" checksum="C744CBE326E3E75B" modified="2013-12-11" version="1">MLGSKLSSFLLLALSVVSLASPTPDPSGRSAGKRCEDPVERKNWNKLSKSERKSFTKAVLCLANKPAKYRKHIPGATSRYDEFHGVHVQQGGEIHFVGHFIIWHRYFLLAYEKALREECGWKQGLPYWDWIADVASGDKMDDWEIFDSEYGFGGNGPWMEIPEGQEVFPVPGRTGGGCVPDGPFTTKNFHVGLGPGANASVSNPHCLRRDFSPEIVEYNLVQETWDEVVGQSDYGRFAKRLEAEPSWGMKNIHGGGHFGVGGSLGDMGDAYNSPGDPLFYLHHNNLDRVYWEWQKKDLKKRLWDVSGPIHMFDYANQKGGNVTLDFEINLGPLSGTRKLWELLDIRREGMCYEFEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L752</accession>
    <name>U4L752_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08011</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="HF935414">
        <property type="protein sequence ID" value="CCX08418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L752"/>
    <dbReference type="STRING" id="1076935.U4L752"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX08418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="704" mass="76968" checksum="7408905FD915ED2A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7G0</accession>
    <name>U4L7G0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7G0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="12876" checksum="0AE43C2D2E9DF585" modified="2013-12-11" version="1">MEKTPQILEESLVPAIAKEDPDQIENRESETLKDRLIRANYLLAVHFISYVGISAIAFFVIPDKLVSNNDYYVFRDKGDKGRISGVTSKLGVAGINACVTAALVVTRLASSSWSSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7Q7</accession>
    <name>U4L7Q7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ankyrin repeat domain-containing protein 50 acc. no. Q9ULJ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_05756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7Q7"/>
    <dbReference type="STRING" id="1076935.U4L7Q7"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4063909at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX06169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="494" mass="53748" checksum="18DB2FF982588655" modified="2013-12-11" version="1">MAGRQSIPLFNKPKPTANKSKPALQPSKPQHSETTPLFQAVHDNDIHTVLQLLSEGVDIESRNPHSQTPLISAAASGHTLLVQSLLSHGASIDAKTTDGHAALHKACFAMHEPVINLLLSSGADWTRSPPSPLFAAIEENDTSIVRRLITSGVSIESRNCHTRTPLIAAAAYGYTSLVQHLITRGADINAKTVLGRSALHEACFGWYIREDLRGDQLSVIKVLIENGADKEAREPHYGGTALTIAVMERNIEMVRLLLEKGADVEVKDHNKKTPLVLANPCPGIRDLLLQFGAKYPEPEVIEVKKARAERVMRSVHLPRLPPPSTPSPAPSPPPSPVSPPDGPVAGRDTGVVDMDKWCALCVRDGHNSGDCPFETDNLAAETEKKMTVHELSSSPELPANGGPVAGKECGEVDIECWCAWCWRYGHDSADCPFETDNPFAEKTGSVRLPQVRPSPALPIEETVVENDSDGMEVDRWCSWCDKDGHDTVHCPFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7R8</accession>
    <name>U4L7R8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_12781</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7R8"/>
    <dbReference type="STRING" id="1076935.U4L7R8"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KRQWKGP"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="236"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="722"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="901" mass="101193" checksum="E3231C0A7D203E40" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8K3</accession>
    <name>U4L8K3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8K3"/>
    <dbReference type="STRING" id="1076935.U4L8K3"/>
    <dbReference type="OMA" id="DRYGYNN"/>
    <dbReference type="OrthoDB" id="5396078at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="230" mass="25041" checksum="37E4F81C14905266" modified="2013-12-11" version="1">MCLIRVKPELDPSEPPIPTRVATSHRNGRTSNRSSVIETIQIPPPPPPGASLAIANGHGARLSVDGRSAHGRNSFNRSRETQVIQHRPPSAISHTGSYRGEGHRSTHGDRDLLGYQGSVGGSRASVISTQSRERGYYVDGTIAGGRSPRSSYRYIDGRSSAQRLEVEDAERSRGGDRYGYNNYHGRRSGSVSYVNPRHSHRSVRSTGGGRVSREKVVVVDSYGEKEGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8W1</accession>
    <name>U4L8W1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 4-hydroxyacetophenone monooxygenase acc. no. Q93TJ5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8W1"/>
    <dbReference type="STRING" id="1076935.U4L8W1"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHASEWP"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX15282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="509" mass="58621" checksum="9DA1F2A8702B87EE" modified="2013-12-11" version="1">MSTDPKKPTQKFVAIIGAGISGIIQGSEVHRQKVCRRPEEEMVIFEKASGFGGVWHVNTYPGAACDIVSHIYSVSWFPKHDWSRRYSPQDEIRRYYNTIAHHYSLEKSTQFRTFVKSAHWSDSDLLWHICAVRDDIEYFYTSSILISCIGQLNRPKRAPIPGASLFTGPQFHTADWDHSIDLTSKRVAVIGTGPSAGQVVPSIAPIVKELHVFQRSPPHILPRDDYIFSPLVKNLFRYVPGAQWLHHLYLYYDQEMGPYRSVHYGTKEHIGAAQASQDHMERQIPPERQDLRDKFTPDYPFGCKRPLFLDNYYPTFLRSNVHLHTMPPIEISETAVQGKEVDIIIWATGFQTQDLLGHVDVRGHGGVRLKEQWGDTAQAYLGTTVHGFPNLFFVYGAGTGLLWGSLTFMFETQALWNVKMMKAVYAAGRKGIRVGYAVREEREEEYNQQVQEKFEQLALGSSKCTSFYKNSKGMVTTNFPWRLADYWWRLLWIKWGEYEKWEKTIPMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L927</accession>
    <name>U4L927_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Vegetative incompatibility protein HET-E-1 acc. no. Q00808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L927"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGHFVRI"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="366"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="994" mass="110556" checksum="F589EF3138F2D401" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9P1</accession>
    <name>U4L9P1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9P1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="15469" checksum="B78D38B1F971DA4B" modified="2013-12-11" version="1">MVLRRLGLIVCSSRLVGGGRRGVGSPTTVPDGGCCGSLLRSPRYARDGEWDWMIRMGKATGREWDGKGRFSWCDFGFLVFFGFFALGIGYELVIHRICSYHTHEGLKWLRRLFCFGELYHDCIVHFWDTVTRPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9S7</accession>
    <name>U4L9S7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Putative ankyrin repeat protein MM_0045 acc. no. Q8Q0U0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9S7"/>
    <dbReference type="STRING" id="1076935.U4L9S7"/>
    <dbReference type="eggNOG" id="KOG4369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="30505" checksum="D181B560FDD41477" modified="2013-12-11" version="1">MRGFSALVCYVGRLSASRTALVEKGADINAENMDGDTALFRAIRYNWHHLHLKNGKLAKLLIKKGADMLAQDCAGRSILSLAAMARLDKIVDLALYKGADIELECHQGRMALSYTASEAQEAVVELLLRCGANVYSRCKMGKHPVAWAAESGYRGITVILLATVACYRFAEDTTPNVNKMLVDSGADLQKLRAIYSISAQESLKKTLRRCLDKYSHVDSNDRLRGKASLLWNYARLEEAGWRVGIGRDEDVHLDSTARVLPSQVAIYEGDKVVQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAH2</accession>
    <name>U4LAH2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936415">
        <property type="protein sequence ID" value="CCX16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAH2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652081" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11150" checksum="2FC3E45FC75C6F33" modified="2013-12-11" version="1">MNFILLKSLFIVMPLAVIGLPAQSPAAGTAEASDGTVVVQQFAYLQYCRAKDYQPREWCQFRSPPFLECQNLSGMWDNSQLGPAHNDQISSYKCNGDCSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAN4</accession>
    <name>U4LAN4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to UDP-glucose:glycoprotein glucosyltransferase acc. no. Q09140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_03131</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LAN4"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651819" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="269"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="406"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="663"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1200"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1472"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1478"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1522" mass="170779" checksum="E24BC8C63B903709" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAY0</accession>
    <name>U4LAY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C29B5.04c acc. no. Q9HGP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAY0"/>
    <dbReference type="STRING" id="1076935.U4LAY0"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RGPMTRK"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="314"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="720" mass="77846" checksum="4F7ADBDBB6A55399" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCF5</accession>
    <name>U4LCF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UBX domain-containing protein 10 acc. no. O74498</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX08002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCF5"/>
    <dbReference type="STRING" id="1076935.U4LCF5"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYAFVEC"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="399"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX08002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="500" mass="55491" checksum="C58EAD1CF005C9DC" modified="2013-12-11" version="1">MSTSSSTDHLTEPQREALAQFTAITSQPESSAIPLLTRSQWNVELAITRFFDGEASTTTAEALQAEEYALAAAAPPAAAPAARPPGPTAAIASASGFGLPRRPTISPAPRIVPQPNSLARRPPLLLSILLFPFSLLYRLTSGTWSLLHLLFPFLPRFRPLPKRSHDPRDTAARFIRAFEEEAGTEAVKLPWHEGSYASALDLSKSSLRFLLVVLQSDEHDDTAAFNRNILLSPEVAGFIQQNEIILWGGSVQESEAYQVSTALGCTKFPFAALITHAPNTPPGASSQGMSVVARLAGVTTAQGFVQKMQAAVERYRPALERIRGERAARDFDRRMREEQESAYEQSLALDRQRAQERRAAEEAERRKVEEAEKARVEKEIRAGKREQWRKWRAGRIEAEPTEGARVSIRTAEGERIVRKFPKEARLEEVYAFVECMGVDADGAEEPSGYKHEYSFRLCSMMPRKVYEPEVGTVGEVLWPSGNLVVESLGEDDDEEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDE4</accession>
    <name>U4LDE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDE4"/>
    <dbReference type="STRING" id="1076935.U4LDE4"/>
    <dbReference type="eggNOG" id="ENOG502RXTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIHMIHG"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32376" checksum="A2A8FFE54000076F" modified="2013-12-11" version="1">MQSHSLNSKGFHEDSFLSIHLHLEMTVDVLILGAGWSSQFLLPLLEKRQLTYAATTRDGRSGTIPFTYDPEAENHTAYRALPKATTVLITFPIKTPGGSKRLLELYRSAHGIEAGQDASKWIQLGSTGVWEGEGVCDRHSTIDLTNARALEEEALLKEGGCVLNLAGLWGGARCPPNWLSRVAPTKEKLADKDMLHLIHGDDVAAAVLAVSEKWDAAKGQRWMVTDMRSYDWWELALAWGDEDTHKKWVLELLGDLTLPRAASGRVLRSTDFWKTFGKTPSRSLLDMPKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDH9</accession>
    <name>U4LDH9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDH9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="4136" checksum="09388BCCFF4DFFED" modified="2013-12-11" version="1">MQIGMKNSAKFEEKFLSSRLFLAKNYRSCTSSDGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDP8</accession>
    <name>U4LDP8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDP8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="15920" checksum="A868178E9921B54C" modified="2013-12-11" version="1">MLEYCLSVSNSSQCRHLRNGTTRHRATRITFPSKQNTTTILDTGPSEATPTHSSSAAPGAWRHSLLRPQALWHLRQPTVSFPTRHSRRIDSRIPSDYAELSRSTLLPLSSEMRGRRYSSRSDLIVEYMPSSMSRIFYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE67</accession>
    <name>U4LE67_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_08270</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE67"/>
    <dbReference type="STRING" id="1076935.U4LE67"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="60"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX30168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="433" mass="46921" checksum="E17712F9819B6965" modified="2013-12-11" version="1">MDRNTTITIATAGALLGVGATLAAQHLLSTPTTTSKSKSSKIKTEDEVELKEDIRNGLEECIGDTPLILLKSLSAATGCEILGKAEFLNPGGSVKDRVALHLLTTAERDGLLTPHSGDKIYEGTVGSTGVSLAYLARARGYLAHIVMPSDQSIEKSSLLEKLGAEVSRVPPASIVDQSQFVNKARSLALEHTMREDIPGRGYFADQFENDGNWRAHYASTAPEIYRQTGGRVDAFVAGAGTGGTISGCARYLKERLPEMRVVLADPPGSGLFNRVKYGVMFDIKEREGTRRRHQVDTIVEGIGINRVTHNFEAGRELVDDAVRVTDEEAMAMARFLVEKEGLFVGSSSAVNCVAAVRAAKKLGEGHRVVTILCDSGARHLSKFWAKAGNVGGGWEMTLDDVLDAGIQKKGMDKKEEELRKEEEKAEFVEFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEE2</accession>
    <name>U4LEE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Adaptin ear-binding coat-associated protein 2 acc. no. Q6P756</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEE2"/>
    <dbReference type="STRING" id="1076935.U4LEE2"/>
    <dbReference type="eggNOG" id="KOG2500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEGHRAQ"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="25238" checksum="DC6015DB648E63F8" modified="2013-12-11" version="1">MTDEVQRVLHTFSKVHIYAIPPLGSNQGYRASQWNVDNEEARIFTARIRIIETYNSETVRTDVRLEDPNSGDLFANCPYEAAFCVEQVVDSSRFFAVRVVDGNNKAILGIGFEQRDDAFNFGVALQDIRRQQDAEKAAKNRTPPVVEKKDYSLKEGETISITIGNKGRRRGPSSNSTSSSDNSGLPLPFLPPPPSAEDVKRRQSRNLDEEEVKFGFDDDAFGDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF88</accession>
    <name>U4LF88_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF88"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4360" checksum="8192C462534CC4C1" modified="2013-12-11" version="1">MKVHSRSVRGCCSSSTSCQYNAQDPPASASMRLSHQAKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFP5</accession>
    <name>U4LFP5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFP5"/>
    <dbReference type="OrthoDB" id="5326422at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="447" mass="48930" checksum="28E8D496BE918BD8" modified="2013-12-11" version="1">MSYNHEPKYPDQVHDVERDSQADISAVDNNVNESQYELRTPLASPGTPGSYVIVSRTNTNPVKEKRPPCGIRSRWLRWALGLFILSVVLVLAIGLPVALGGNKTNKIEGPQAPSNNHPDVMAPVPRISVYKNSALGVLASSRNSKLAFQGPDGQLDIQEFTVSDDGRHATLGTSYALSVITEPKEKTPIASIPFEDNQAAIIYIAKNNTIQSREGILAIEELRSSSSLSTSAIDVHEQSQIAALSYSALQTAGVFFQFPNGSIVSYHIVNNLWVFDQVLPITGLNGTALAVVDYKPISGANETRLFYQDVNSTVVDICGNGELGSKMKWAPCQIKSPTMKAMPFTSIAATAAGVNGYLRILYHSSDNSGMYLMDTWYDGNKWHGPVAIEFIIDPSAQIVADPYPYGYGDTSVWYSNGTRVEQLIWRSNVQMWDPVEEFGLSPENSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFW3</accession>
    <name>U4LFW3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Probable O-acetyltransferase CAS1 acc. no. Q8X226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_08621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX30422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFW3"/>
    <dbReference type="eggNOG" id="KOG1699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSAREWA"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="10">
        <location>
            <begin position="307"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="757"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX30422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="829" mass="95369" checksum="CE36F4139C623552" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG73</accession>
    <name>U4LG73_PYROM</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="151" mass="17295" checksum="5480BE68D3B3A47D" modified="2013-12-11" version="1">MVTADVAPSGLNPSQSRNDAIQIFLNSASLIIAIIMLLLKVIKRSGKHRRPGPGRCDIFPNIILHRYQLCYPIQLLITTGPENVVPIVESIRHNRTLFYKIIYGLKICFDTFFRLARGVLEFTIVQPTLRLLRFMYIDEVRTFEPFACDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGB5</accession>
    <name>U4LGB5_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Similar to Eukaryotic translation initiation factor 3 subunit A acc. no. A4II09</fullName>
        </submittedName>
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        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30943.1"/>
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    </dbReference>
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            <begin position="55"/>
            <end position="426"/>
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        <location>
            <begin position="153"/>
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        </location>
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        </location>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="426" mass="49772" checksum="FADF93E89C18D358" modified="2013-12-11" version="1">METSTWTYKSPGSQYNGLKLSDFIKIAEYRNINFNPRITGEKFVTKIESDDSWRRKLGQPWGLKASPFSERTGPRTKWAPRKEDRDNKDKSSESSERPSNGNFFEGRRYDTGLPARPRHSTGFPDREGSERSFDRPERPYSAYRQENSGPRELNPERQSSDRREYNSDRPPREGFNSDRPPRREYNSDRPPREGFNSDRPPRREYNSDRPPRREYNSDRPYTPRDFNSDRPQHYPSRDFSRPAYDPTNRPSYNSDRPSKYFSPNSSRPHDSSGERSLNRTSNPNSSERSLKLSSSPPSSDPDSSSAAQGSQSSQDDSNSSPSESSERTPQLDPHQRFSYQGTGQRSYPPHRPNPYARDFPDGQSKKPWSPMVRPLPRGLQKWQKQELAWTPRGEWTDKMDRYRGDKDRGYGGDRDRRDRKKGEWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGD4</accession>
    <name>U4LGD4_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09639</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX30963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGD4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7201" checksum="0E65E0245D67EA4F" modified="2013-12-11" version="1">MQQIKQELVHISDILVKISNPVRIEEFQDGWKSTLSTLASPDGPLEPLKQTLQEIENRMKNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGH3</accession>
    <name>U4LGH3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGH3"/>
    <dbReference type="eggNOG" id="ENOG502S9VS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NICGREM"/>
    <dbReference type="OrthoDB" id="5414338at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="766" mass="79552" checksum="7E46DA2387F83932" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGN9</accession>
    <name>U4LGN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Pre-mRNA-splicing factor cwf19 acc. no. Q09909</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935574">
        <property type="protein sequence ID" value="CCX10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGN9"/>
    <dbReference type="STRING" id="1076935.U4LGN9"/>
    <dbReference type="eggNOG" id="KOG2477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMKCLTR"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="489"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="621"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="726" mass="84857" checksum="1151B63EA5D47003" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH53</accession>
    <name>U4LH53_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH53"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="169" mass="20190" checksum="964433995C970FF1" modified="2013-12-11" version="1">MSRTEASQFPEYHEIRELQDDMYRYVVVQEFGWKPRANHDFLSLERQMEILHKDLKPETKKPVIGEPYTDHVEAKLVKIYEIDSLILNLGKDDCPFYAKRTIPLFKECKKVIFRNLVHGVNLEWDEDYMNYTADQRRELIKTHRVLENGYTVTLSLEIQLLYLYTRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHM9</accession>
    <name>U4LHM9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHM9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="27" mass="3110" checksum="E976D9B1A8837322" modified="2013-12-11" version="1">MILFVYNFSDAVRMQVVSLGFTRRAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHN7</accession>
    <name>U4LHN7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHN7"/>
    <dbReference type="OrthoDB" id="10359335at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="329" mass="38595" checksum="C916E81A01DC6D4C" modified="2013-12-11" version="1">MPIWEPLDPSSSSLTFHKIPLRLTHSNQHRVELSLLTTDLSSLQFHDLLLSYNGVFTHLQHAPKLTLRYGSIGIPNQTSPDRISPYDRGHTSTFIPFYSVSSFPSAWQEALTRSNGMIKFISLTFEYSFSEWQDIFAANKAEREICLTYRTTTAERAYRLTWAREGNWKQKFKGHEMAWTRPATLREGSRWKGGDTKEQPWMEGYTLVAPVGYDNSEPEVMWPELKHYDGVVDRKALEEENKRCGYGLKVKETPYTKFWRRQQENKSLVNRMKMDRTVDRDTERLIDDLELNGMKVWVYFPEKKGAPLEFYPRYHVKVLEFQPEAQYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI19</accession>
    <name>U4LI19_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to HECT-type ubiquitin ligase-interacting protein creD acc. no. Q6SIF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935656">
        <property type="protein sequence ID" value="CCX11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI19"/>
    <dbReference type="STRING" id="1076935.U4LI19"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GMATPFH"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="179"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX11964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="573" mass="63138" checksum="6BEE2BD8E379B4CF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ73</accession>
    <name>U4LJ73_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX31998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ73"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="13313" checksum="9DC56782E9EA3CA4" modified="2013-12-11" version="1">MQKRTASDLRNMHCFHFRRGNKQLLIKITHLGTTLTPEHKSSISADVSVSNWRSEFNSETFSDKLAQRVSGANLWTGNARSALQIVVRCSAQFISVKLREDFGFIRRFFKDNSSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJH6</accession>
    <name>U4LJH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Regulator of drug sensitivity 2 acc. no. P19541</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_12373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LJH6"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRCVKRN"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="535" mass="58823" checksum="64E8DA7D4CB4C107" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJI1</accession>
    <name>U4LJI1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJI1"/>
    <dbReference type="STRING" id="1076935.U4LJI1"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="236" mass="26127" checksum="71A9194915C2EBFB" modified="2013-12-11" version="1">MSSSSSTPLLYSCIAHGTTILCEHSSPGTASVNASSLAAIVLPKIPHDEAKKLTYTHGPHNIHFIATASSSVLPQGLSFIVISPSSVTRKLPFGFLIEIQKLFLARYTQSSLADAPPYGCAEFNSVLKSTMARFSQGGEDEDVVIKAQREIESVRGIMTENIERVLERGERIDLLVDKTAGLQTGSREFRVRSRGLRRRMWWKNTKLMMLLVFVCIFLLYLFVGFGCGLPGWQRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJI3</accession>
    <name>U4LJI3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJI3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20046" checksum="674957020C3A5A11" modified="2013-12-11" version="1">MKMRKRRYMKKMMETMKNKCVRNILIKALRFRTPLVLPVNPGVDVSGPPALTGPDGPDEDVQPEPDKTSFPSACNTLKYSTPIVDCTNKSADATADTSAPAAGIAPHFSQMEPNSTTQPDYQNFDLASGVVELFTFYETPVPTVEDVHSHILKNFPMLIPAIRAVADPDLTAPAVMAANGGIAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKU6</accession>
    <name>U4LKU6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKU6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="10184" checksum="A994F609756108FC" modified="2013-12-11" version="1">MGTTQNFERCVLKMTFSKEPHLRMNHVASPTKYIGDLAKDPHGLSRPRRLYPAPTQRSVVISREEDSLHNHDYAPATWDEILYFSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL87</accession>
    <name>U4LL87_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_13273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL87"/>
    <dbReference type="STRING" id="1076935.U4LL87"/>
    <dbReference type="eggNOG" id="ENOG502S7VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGKQWHD"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX13680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="146" mass="17343" checksum="40DB3C2941EDB394" modified="2013-12-11" version="1">MKFHKLVALSRIPRKKVTTKPRNTKMSEVAAATPIAVAVPEIKGARVNGKQWKQTKTQFRPGMASGRKTFEERQVERQAYAAMKAREKEMKDEKIQKKKELSEKLKERREKKEEKERYEKLAAKMHQKKIDRLKRREKRNKALKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLM0</accession>
    <name>U4LLM0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein L509 acc. no. Q5UQ73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLM0"/>
    <dbReference type="eggNOG" id="ENOG502RZN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFTHHAP"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="256" mass="30019" checksum="05549DCD27B551DE" modified="2013-12-11" version="1">MRFQILSDLHLESPQAYDLYEFPVTAPNLALLGDIGNVRDPGYFLFLRKQLGRYERVFVVLGNHEPYYTDFSTARRKLGEFEKEWKGRLVFMDRTRCDVDERVTVLGCTLFSAVPKDQKENVGVGLNDFYKIEGWTVEHHDQAHREDLAWLNNEVKKIAGKEPHREVVIFTHHSPTAADIANNPRHKGSLISAGFMTDLTNERCWTERCVKLWGFGHTHWNCEYKDEKTRKLVVANQRGYYFNQSLEYRPERVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMD8</accession>
    <name>U4LMD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMD8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5382" checksum="F1B4F36272F1F9AC" modified="2013-12-11" version="1">MTKVAPGEIYAALMKEDRLNRIGYRYLSRTLLVWSSVFTDGDMTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LML9</accession>
    <name>U4LML9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936048">
        <property type="protein sequence ID" value="CCX33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LML9"/>
    <dbReference type="OrthoDB" id="10554416at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651587" description="Hydrophobin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="12836" checksum="EACD8578287F220D" modified="2013-12-11" version="1">MQFTTAILAIFVASAVAVPTFGSGDGQCNFRQNNQVQQGSVICCIKGDHTSSGSTQSGSGLIGNVLGLATGDLLSDISCAVNLCGTQALNNVGVLANNNNAICCKNVNSQGVINVNVLSTSCGKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMR7</accession>
    <name>U4LMR7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA ligase</fullName>
            <ecNumber evidence="9">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_14278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="9"/>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMR7"/>
    <dbReference type="STRING" id="1076935.U4LMR7"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHTIGNA"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="12">
        <location>
            <begin position="629"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="718"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="834"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="973"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="842"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111246" checksum="E94377EDD4DD1D47" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP26</accession>
    <name>U4LP26_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02935</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX16339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="480" mass="54868" checksum="F9746BFC0DC0A861" modified="2013-12-11" version="1">MPVGLESAFEITINRIRSQNSQRAEQAMNVLMWTFQGERNLTISELQHALSVTITEDDTPEMEEELDWDSFPTEKSLVDWCLGLVIIDEETSTVRLVHKSFHDYLTRRHKQGSLFPNCHGTMAHICLKYMYFLDDNQLDPSNAESTAGILKSRWEKYCFLDYAVDNWGHHARQQTTPKVLLLGTGLFLGTTKLNRISVYLHALGHVEPLSVLRSSHYLCERIAHCIKGNPELYSCLGLSHAAYFGLDQFFLIMIERLPHYLNRTDSPRDITPLRMAYLEGHEGILRILLNQKNINLRIRDERGDTVFHMAARYGRVSLVRLFLEMNPANLDFNSTDLANRTPLITAIVTATRRLRGVDVNFRDEYGWTPLMGVARRGHKAIVRLLLEREDIDINLGDKYGCTPLMRAASIVHEAIVRLLLDREDIDVKEDGPNVLRGVLKGEGEDTEAIVKLLRTKLESEGVRENLILLSELIPESDMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPE8</accession>
    <name>U4LPE8_PYROM</name>
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        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936091">
        <property type="protein sequence ID" value="CCX33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPE8"/>
    <dbReference type="STRING" id="1076935.U4LPE8"/>
    <dbReference type="eggNOG" id="ENOG502SNJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="552" mass="61791" checksum="D876A595BA29C827" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPK6</accession>
    <name>U4LPK6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936491">
        <property type="protein sequence ID" value="CCX16625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPK6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="116" mass="13157" checksum="48F62D6BE9C3ED7E" modified="2013-12-11" version="1">MKCHVAPQACAEFRSSGRWIKATWRRGDCQVTSSHSPPSLVLRYLLNKSFQQLISNYHHSGFFPHNLTITSFQILKVSTSRIQHRGAQSTDSSSKYSAHHIRPESSRARVSSPSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ16</accession>
    <name>U4LQ16_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ16"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2279" checksum="780F5AEE93CCED51" modified="2013-12-11" version="1">MFAKDELSLRSQRRAGKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ56</accession>
    <name>U4LQ56_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_02568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ56"/>
    <dbReference type="STRING" id="1076935.U4LQ56"/>
    <dbReference type="eggNOG" id="KOG3463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QYYELYR"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="13178" checksum="0F4591173D8D5F23" modified="2013-12-11" version="1">MATPANPYYELYRRSSIGMALTDALDDLISEGRIAPQLAMKILNNFDKHVTEVLSEKVKANLTFKGNLDTYRFCDEVWTFLIKNVTFKFQQQGGATPAVTTDKIKIVSCNSKRPGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQE8</accession>
    <name>U4LQE8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQE8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9918" checksum="43E5C56F7E706AB9" modified="2013-12-11" version="1">MALVGDCVIHFPSPSPYLKLHAMSRPFKTLLNTLEDSFGFMIRRYFYSVSEDLRCPATRDIGFRVGIDDYSYHMATITTAMGLARFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQJ6</accession>
    <name>U4LQJ6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_03034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF936394">
        <property type="protein sequence ID" value="CCX34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQJ6"/>
    <dbReference type="STRING" id="1076935.U4LQJ6"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EWCELRP"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="48971" checksum="7479A3FD4D7084AB" modified="2013-12-11" version="1">MSTPKKHISYQFGGPIGALGVTLGTPFVTYALYFLCNENGCPSQSFLDAPLQHLAAQWPGWDKVFSSKVFGYYCAWYFGIAAAQFILPGKTYEGVELPDKTRLKYKLNVLQTAITIFGYLGLMTYREGFSFGIWSWIWENLLYLQTAALTFSIILAFYTYISSFFTGEILAEHGDTGNPLYDWFIGRPLNPRIGSWDLKCFSELRPGMILWPILNFTFLVHQYQTVGRITDSMILVNVFQFWYVIDSFINEPAVLTTMDIATDGFGFMLTFGDLCWLPFTYSLQARYLAMYPVDLGLLGVGGVLLVQAIGYFIFRGANGQKNKFRTNPNDPACAHLKVMHTKSGSKLLITGWWGIARHINYLGDWIMAWAWCLPTGFGTPITYFYVAYFAVLLIHRDRRDEEKCVKKYGEDWEKYKKLVPYRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <taxon>Pyronema</taxon>
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                <person name="Kumar A."/>
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</entry>
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</entry>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="2716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2716" mass="295388" checksum="3FC5AB19CA3C73B6" modified="2013-12-11" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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            <dbReference type="EMBL" id="CCX32850.1"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="59" mass="6796" checksum="31DC12926C55CA77" modified="2013-12-11" version="1">MDIPKQAAGGPYLPMFTYRFDMIVRPVQQRWEYRKAKLDQVASQAPVDSLIAELKRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTJ6</accession>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="28400" checksum="F1A8EFCA7E380B4F" modified="2013-12-11" version="1">MVLHNDKWHRKAKRTYIRKGGEIEPKKGTVDPTKPAIPTAAADPKPGEAPGAPIKDGEAGSEEEQEEEEEEEDGDYRRRKVGSNAWRYEEEEPEFPLEANPDEPQEPEIDYVALTLERTKGQLKDEAEVSTSIDHEFLAESWGAPKKKPTVQKVKIDEGILNIREKIEIRNNAEAFKARFGSKAKARAPKGIQKEKEEGVDDIDDFLEELSLIEKEKKPVVQKETQVPKPKTISTTKDEDDEWLDSMLGGR</sequence>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="6204" checksum="19D88C8389DE2B77" modified="2013-12-11" version="1">MTIMKKLPTKFAKSLFVFYAAAVNMADTYDITRLSNDRKSRQQSITSENRATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUB8</accession>
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="21" mass="2476" checksum="F5AC5DF21C2C9E54" modified="2013-12-11" version="1">MHVHGPTRIHNINSRPPPRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV13</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LV13"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3557" checksum="815D8320DF8F4C49" modified="2013-12-11" version="1">MLCYGTRVSGWDNEEEAKMKRSGAWWVIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV77</accession>
    <name>U4LV77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV77"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="12154" checksum="08B4E5EDCD83DF49" modified="2013-12-11" version="1">MSPRLPARTRRNELQNDFSRSSQLQPRTVVACLDVSQLGALGPFLTAQRPGKIRCFRNSQSSSDCFEQREHRCWGTGSRTPRNRTNVSTEFQDESNKHRMFPSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVD5</accession>
    <name>U4LVD5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ADP-ribosylation factor GTPase-activating protein glo3 acc. no. Q10367</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVD5"/>
    <dbReference type="STRING" id="1076935.U4LVD5"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="426" mass="45526" checksum="DBB10A8A2AC8E00A" modified="2013-12-11" version="1">MSLASKTESQKLFEKLKSQRANKVCFDCNSKNPTWASVPFGIYLCLDCSAHHRNLGVHISFVRSTVLDQWQWEQLRIMKVGGNESATKFFQSHGGAAALASKDPKVKYGSNAATKYKDELKRRAAEDAKVHPEEVVVDSIEGDADTAASTPKVDEDDFFASWDKPAIKRPTPPPSRTATPPVIGRVPSPLTPNGSTPATPAATTTTTTSTTSRIITSKKTLTSSTTKRLGATKTKDILKAKPAAAKIVDFDELEREAKLGYVEPAEEKEDIPAFSSNSTAAEKKNDSYGSSSYGSKSSTPAAPKVQAPRLGFGQISNTPVDPAVVAEKKYAPKSMSSADFERKAEDPAVKAQRDARLAQFSGMSGFSSDDYNGGGPGTGSSSSGGYAGNDYGVNADKIAQTVDEVVDMTRQVALGAARTLKQYGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW56</accession>
    <name>U4LW56_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_14251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW56"/>
    <dbReference type="STRING" id="1076935.U4LW56"/>
    <dbReference type="eggNOG" id="ENOG502S6EF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KYKLRIH"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="10">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="113" mass="12336" checksum="9246B2A0BF81B2B4" modified="2013-12-11" version="1">MSALSAYRHLLRSARIAFEGDAMMFNAAQQESRKAFEQNKAVAGEAAEALVKHAKEVAIILRTNVIQGKKEGDEVYKLNIHDEIERGDNESIKKGRKTQLEMGGGCCGGSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWG1</accession>
    <name>U4LWG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936171">
        <property type="protein sequence ID" value="CCX33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWG1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3132" checksum="B0074C1339053A6C" modified="2013-12-11" version="1">MAAVDAVAGDDSSGCTRGCNDTGSCSVGNRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXU8</accession>
    <name>U4LXU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein SMG7 acc. no. Q92540</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXU8"/>
    <dbReference type="STRING" id="1076935.U4LXU8"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACENTIF"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="1">
        <location>
            <begin position="199"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="626" mass="70853" checksum="C732C2F1B16B39EE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU41</accession>
    <name>U4KU41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935215">
        <property type="protein sequence ID" value="CCX04738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU41"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="232" mass="27130" checksum="310C70A0F7283B4F" modified="2013-12-11" version="1">MPYKINYKQTFPCNFERTSHGALWRQIIGESNHPTSPRPLYRPFEDSRALTGHVSNRLHNSRYGHYDGHHERQVFGLLIDYYELWKTPVIASGILDEIANATRSASKDGMNLDQLKTLEAVLGGWLEDCEIVMGWDEDTMYVQAAWFWTLQERILDYEGSRYGNHDGCRILKEEDLEAARGLERIMDGCRAKEDRNVFMVMWMFMDVLCQKIQIMQEEENRCLTEFLSDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUG5</accession>
    <name>U4KUG5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935220">
        <property type="protein sequence ID" value="CCX04928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUG5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="478" mass="50434" checksum="CFF8D4138B9B1B25" modified="2013-12-11" version="1">MDPADHDFDAASVEPLLEHADEHAQNDPVATDAVDKTSDSPPPPSGSQLPVSQLPPIGTFFPTLLPQIPSASPAPLPPPATSTPSSAVGSGNAVAATPSLTRRAMGYPMQKACLAQCGLPLDGLLSWTELPQAVQEAAINRFLLLENIPSTTREFAIDHLWTQMGKYKDEKKRQAKRAAEKAVKANGTLGGTVMPGQSLTDSTISCAVTPVGSMNPTAQGRNSGFPTVAAERPVLPDNVFAGFGNRPTGTASTFTPAAGTSSQPAAATPSAAAGAATETSTPVPRKRGRPLGSKNRPKAPASDSATPTLILRPQNPTSTTGSTSAAASPHLPQSEYQPILWRPGTIPVDHKGHIYLSRESLSEFSESARRYYEGRYTIHIRDSTPERITGEQVVATNEGQNVLMGIVTDSNDEVEEGEIVEVQGLAPAETGAEPPVVVTNERGEQNASMGIVIDSDDEVEEGEIVEERTPVVKRRRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUH2</accession>
    <name>U4KUH2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935214">
        <property type="protein sequence ID" value="CCX04687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUH2"/>
    <dbReference type="STRING" id="1076935.U4KUH2"/>
    <dbReference type="eggNOG" id="ENOG502S7RA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="332" mass="35961" checksum="D9A833F299DF1DA6" modified="2013-12-11" version="1">MARHSHTHPAARSPTHQSSAQNGTSGGAPRRRIPVACARCRKRKIRCSGDPGDNSGCLNCKGASVQPGQCQFLRVASSTIEMAPLQSSSSPAVNHVNATGLPPNSMGSLSGGHTSAPMLSMQNGFTSIDHNRVYRPEPVTTTYDSAPSYITSEMPQTSTSYAHHYLPSTPHAGNYDSSDSTLRSQNSEYRQQQQWDMTPKTMPVPGSSPYSYSDANSSQLGYNSTPVRSSSYSDSTPSSSLETSNYTNFPALGSLTNNLPKGEGGSRSLPEGNLFNNLTLPFPSTLPPPTVTSREYNFNANKLSQQLRFIISCDAYKQPEILISIRFSKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUM3</accession>
    <name>U4KUM3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_03668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUM3"/>
    <dbReference type="STRING" id="1076935.U4KUM3"/>
    <dbReference type="eggNOG" id="KOG3790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IREPNIN"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX04777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="491" mass="54952" checksum="D56E1D048F63A212" modified="2013-12-11" version="1">MSEFPAHPPSLHALDHSNNQQTWQPILTEPFPFAPSSFLAALEQMSQHPEHNTSWILRSDTLYDSTDPSSVPGDSDIRKIQTPGYAITRTLTRRFIPRNPQRDAYAEQTIHFLTGTDLSGEIRELIVYLNHCDTAEGTPYYLPKVRGVAWLLTPLEAGEEEGEGEERRKYKITLLYSLFTSPPDERLKRTALHLLARATKLAAGIESGYIKRVHHDLVVKREGFQDRYLALKAKHAARLVEGWRERTDPKKHVFEDILIATFLVCLWEGMYPDKKGWVGFADIGCGNGVLVDILIREGWSGCGFDLRARKSWGGFCEETQAVLKERILVPFLLGDEAEEGDHDGRFQEGTFIISNHADELTPWTPLLAAANRCPFLAIPCCSHDLSGAKKRFPPPKELEGTEAKGDLRLNMNLSKSTYASLCAYVEGIAKKCGWAVEREILRIPSTRNLGIIGRKLVDEEVDIAEVLQSEGGGDGWRIAVAALKKKEAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUU0</accession>
    <name>U4KUU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="9" mass="1200" checksum="9F39440ABB42C9D1" modified="2013-12-11" version="1">MTFVYDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVG6</accession>
    <name>U4KVG6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="343" mass="39796" checksum="47425F0027017341" modified="2013-12-11" version="1">MKTQPGCPPDCDCINTHPGFRRYRPVSRHESPVYLFRKGLDHPWAINHEDEEEYYRYDEDMDSDSDQTVTGSSCSSTGVRPGSPYPQADDADEYYNVDNNNYLQQESHGASVRYRTPTPHPHKGELRTQRKKHAVEIDEDNYESEEEDSFVLESCLSTLPVKDGVRGHYSRVKSATKTKSKKSKDRIKKYAVEVDEENYDHEVDDGYHFGVDSCFSTLPLKDGVRGHYSRNKSDSKAKSRKSKDKRHSRYGNIDVNNPTTERRGNSICDSLKNSRFAREFMEAYDAQKTEQEMVYWKRESLRKCKAEDAKRGSVHDDDLWRMLGGREPRRRRITIIEAAKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW33</accession>
    <name>U4KW33_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935243">
        <property type="protein sequence ID" value="CCX05256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW33"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6524" checksum="8A1CC082C7D48BDB" modified="2013-12-11" version="1">MAHSAQRLLRCNLCWYRVARVAVVECSSALLHSVHRSQRRMLCICGGVFLEQHWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW50</accession>
    <name>U4KW50_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_04878</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935244">
        <property type="protein sequence ID" value="CCX05291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW50"/>
    <dbReference type="STRING" id="1076935.U4KW50"/>
    <dbReference type="eggNOG" id="ENOG502RZQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIQFHIP"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX05291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="443" mass="48389" checksum="1B5858DAE3DDFF3D" modified="2013-12-11" version="1">MAQRPQSLTAELERIEMQITLAMQEIDANFARAHRIITNSIIPVVERYQTHSDAVSEGTKFWRQFFETSAGITLNTVKETNETTIADETTMRADNTGVSSPGNYREGGDGSMGMRVPLNDDSELLEDPMEDDTIMASLQMQSTPQPRQSWKEEETDSSYQMLAQELTAKYDLPAPGAANPQQMLEDESSLGIPPPSTPRTSKPRGGYQGSESPESSMMQPATTRPPPTTTPGRLLHQTATKCWRIQATPGTAPMSKYRSTAASMIPSVTTPARPNQPKFNVDDDSPLSSPIQFPEFQTQVLNTPGPAHARTPARLMMTRDWGFTGGPPGTVKAKTPAKTPAKNTYGGYDFGDSDDDDIFLPPGFSPPKTMQFSIPASKLIATPAREASRRIVKDILQTAGADDTMTTTDTGEQRSFVGEESSFLEDLRGGPKKAVKEEDPFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWI7</accession>
    <name>U4KWI7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWI7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="167" mass="19692" checksum="4567153E3186BF2B" modified="2013-12-11" version="1">MTTNSARPQALTPSSYHARKIQDLKDIHAEYHYFYRNVFQTNSVDWLTRGIWRSIENARSLRVRRIDEQMTFQATVAAIGQYEDMLQRCFSDTKLWQPESRCTWHKLKLPNPKGSTESSAAKNFKQRVVKFEETEYQNIVQNWKGVCDLCLTERLQRLRAARESSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX96</accession>
    <name>U4KX96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Survival motor neuron-like protein 1 acc. no. Q09808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_05523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935277">
        <property type="protein sequence ID" value="CCX05936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX96"/>
    <dbReference type="STRING" id="1076935.U4KX96"/>
    <dbReference type="eggNOG" id="KOG4327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMSWYFA"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX05936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="178" mass="19462" checksum="98F87511054BD038" modified="2013-12-11" version="1">MATAPSFNEKETNLTHAEIWDDSSLVEAWDDALKEYKKYHSIAAKGEDPEAVMKATESGVVATADQQTETEMRDAPAVKTAEPVIEDNSTHKAVLEVEIEDVKATDAPSVQTPHMPTPQQAQVEMPSFPFAQPHPAGPAAGFAIGGNDEAMRNLMMAWYWAGYYTGLQEGQQKAQQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXE5</accession>
    <name>U4KXE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXE5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8819" checksum="02E980034F246708" modified="2013-12-11" version="1">MTTARHIKGEQKRAKTRLRAEQALSIEEFTPLLPLPRGLATYRIHTCHQPFSALVTRSVSTLASISNYPLRSCIKRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXV4</accession>
    <name>U4KXV4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935201">
        <property type="protein sequence ID" value="CCX04384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXV4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="5885" checksum="169AB46BABBCD16A" modified="2013-12-11" version="1">MMAPSAASPNNHEHAMVLASVRTIILHGQKFTEMRYVKSKTTSAQRLRLDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ36</accession>
    <name>U4KZ36_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ36"/>
    <dbReference type="STRING" id="1076935.U4KZ36"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YENGQHC"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
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        <property type="entry name" value="PRKCSH"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="162"/>
            <end position="263"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX06965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="544" mass="59967" checksum="3F5B422EDEFC0C28" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZF5</accession>
    <name>U4KZF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein AHC1 acc. no. Q12433</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_04656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935232">
        <property type="protein sequence ID" value="CCX05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZF5"/>
    <dbReference type="STRING" id="1076935.U4KZF5"/>
    <dbReference type="eggNOG" id="ENOG502S5YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="647" mass="69999" checksum="691BC59068E85E81" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZG2</accession>
    <name>U4KZG2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to E3 ubiquitin-protein ligase RBX1 acc. no. P62877</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_06682</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZG2"/>
    <dbReference type="STRING" id="1076935.U4KZG2"/>
    <dbReference type="eggNOG" id="KOG2930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTCVECQ"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX07095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="12263" checksum="A6F235D2886588FD" modified="2013-12-11" version="1">MADVDMKDAAPSKSDAPSGSKPRFEWNAVALWSWDIVVENCAICRNHIMDLCIECQANQASAVSEECTVAWGNCNHAFHFHCISRWLKTRQVCPLDNRDWEFQRYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZJ2</accession>
    <name>U4KZJ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Carboxylic acid transporter protein homolog acc. no. P36035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZJ2"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SDITWGI"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX07610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="488" mass="53919" checksum="87B56F0A5B7C5641" modified="2013-12-11" version="1">MSMSAGRYALTRFTSLAPKGIEAPPNPFTTLRTVNWKQWKFFLIAFWAWTLDALDFFTVSMTVTSLATEFKVSKKDITWGITLVLMLRSVGAIIFGVAADKWGRKWPFIINNLLFIILELITGFTTTYKGFLAVRALFGIAMGGIYGNCAATALEDAPPAARGILSGMMQQGYAFGYLLAVVFAKALAHDPVHHWRPLFWFAACPPALLIIWRFFLPETDAFIARQELRRQEEVEGVANVFIKEAKAGFKKEWLMLLYLVLLMAGFNFMSHGSQDLYPVLLESQLGFSVNKVTVTQVVANLGAMTGGTLVGYWSQAFGRRLTIIVACIVGGALVYPYSYTRTGNNIMAAAFFEQFMVQGAWGVIPIHLMELSPPAMRTFVVGTAYQLGNLVSSASSTIEATIGERFPLPDGHDGEKRYDYGKVMAIFMGAVFAYVAILTFVGPEKLGRDLQKITEDDVVAPKGKLEGDVEHGENVTGEVEKQEVRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZW8</accession>
    <name>U4KZW8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07832</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF935402">
        <property type="protein sequence ID" value="CCX08239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZW8"/>
    <dbReference type="STRING" id="1076935.U4KZW8"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACHEPHV"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="591"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="595"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX08239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="811" mass="89930" checksum="ACFABDA15B7B3458" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZY4</accession>
    <name>U4KZY4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935243">
        <property type="protein sequence ID" value="CCX05284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZY4"/>
    <dbReference type="STRING" id="1076935.U4KZY4"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="264" mass="29408" checksum="A894A2C4E050633F" modified="2013-12-11" version="1">MNHLPEAWGRPRDDIYGAYDHQYVSASNPNQHTTSPVVTGTSVVALKYNGGVVIAADNLASYGSLARFTNVERLKQVGSHTVVGASGDVSDMQFLFDEQLEQLIISEEYQNDGHHLRAKHIYSYLSRVMYHRRSKFNPLWNVLLVAGWDDGKPFLASTDLLGTTFSGPALASGFGAHLAIPLLRRVCPDEAAVANITREQAISVIEECMKVLFYRDARSMNKYSMSIISGEGDKVEIEHRKDIQLKQQSWKFAESIRGYGAQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZZ0</accession>
    <name>U4KZZ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZZ0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5370" checksum="22B9254989F65C5E" modified="2013-12-11" version="1">MLHFLNTSGCVRQAAMVYLESDIRGMQEDIPCCDRCIARDGYIRCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L051</accession>
    <name>U4L051_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L051"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="13126" checksum="46BF0F9A6A68C470" modified="2013-12-11" version="1">MAQSGDASESSKKRNFLDPRRLLRRNNNDSKNMPMVPVDIPTLLTDLELDSSPDMEKLMAIVPGIRAAVSSYGEQSCKWEFTAQKRLENLVGQLKLHNTNLEQLRSMHIQHKVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1S1</accession>
    <name>U4L1S1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Calcium-independent phospholipase A2-gamma acc. no. Q8K1N1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_09118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935469">
        <property type="protein sequence ID" value="CCX09525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DRHWPCE"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="816"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="885"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="923"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="925"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX09525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1387" mass="155857" checksum="A8ADF4C11CA86B56" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L264</accession>
    <name>U4L264_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Periodic tryptophan protein 2 homolog acc. no. Q9C270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935494">
        <property type="protein sequence ID" value="CCX09741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L264"/>
    <dbReference type="STRING" id="1076935.U4L264"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="738"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="843"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX09741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="887" mass="99247" checksum="462510F54C396052" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L370</accession>
    <name>U4L370_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L370"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5480" checksum="7B4BDB5061758300" modified="2013-12-11" version="1">MKVSGNSEDHINTCANPHAVLRSPELFIVTHRRMKGVFEGISSKSIAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3K7</accession>
    <name>U4L3K7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_03071</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3K7"/>
    <dbReference type="STRING" id="1076935.U4L3K7"/>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQDKWAA"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="565"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="922"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX04640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122523" checksum="BC6927AF10380E4F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4Q4</accession>
    <name>U4L4Q4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SUN-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_11636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4Q4"/>
    <dbReference type="STRING" id="1076935.U4L4Q4"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EFFCPVS"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="12">
        <location>
            <begin position="214"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="741"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="885" mass="95767" checksum="C8D9A1FCAF9C241A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L569</accession>
    <name>U4L569_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04777</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L569"/>
    <dbReference type="STRING" id="1076935.U4L569"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="288"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX05190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="344" mass="35383" checksum="7F6DE2DD3BDBE956" modified="2013-12-11" version="1">MLANRTVLRALRTSRSNATYATVSRLLSTLAVLEHRGGKVSAGSLPSISAAVAIGGPVTAFVAGADSAAVAAEAAKLEGVSKVLHVPNGAYDKGMPENFAPLLAENIKAGGFTHVVCAHSAFGKNIMPRVSALLDVQQISDITAVKDQNTFVRPIYAGNAIATVKSSQATNVITVRGTAFAPAAEGSNAAPVEQSTVDPNAPQLCEWVEENLAKSERPDLATASKVVSGGRGLKDKENFDKYMPPLADALGAAIGASRAAVDAGFADNSLQVGQTGKVVAPQLYMAVGISGAIQHLAGMKDSKVIAAINKDADAPIFQVADVGLVADLFTAVPELTTKLEAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5I7</accession>
    <name>U4L5I7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protein LOT5 acc. no. A5DN53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5I7"/>
    <dbReference type="eggNOG" id="ENOG502S43V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMHEYFD"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="275" mass="30009" checksum="AD0E9216848A359D" modified="2013-12-11" version="1">MPLTIIRSPPSADSYEPLSSFQAATPASFSTPVLHHHEVNAKVLLSRDQASLIPIFLPADSKQGDADTESTDEIIVDGIDLWVTNENLIFFNTPLSVGAVIPYLSLTLHAVTTASLGTGLYLQISLTPDISTTSNADNYDDEELLELTLIPTGTEDKTQKQISDIIFKELSVCTSLHSAASGSEDEDDGDRIMFEGDNEEGDAPYARLEGFPGEGGWITAENVDQFRFEDVDVEVPFTILGPGAGVVRQREDEEEEVEEEGEEGGKGETKWRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6B4</accession>
    <name>U4L6B4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935699">
        <property type="protein sequence ID" value="CCX12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6B4"/>
    <dbReference type="STRING" id="1076935.U4L6B4"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="643" mass="69696" checksum="9C62D9E82E081CB8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6D1</accession>
    <name>U4L6D1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Uncharacterized ABC transporter ATP-binding protein/permease YOL075C acc. no. Q08234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935700">
        <property type="protein sequence ID" value="CCX12351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L6D1"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACGYFVQ"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001433">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
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        <location>
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            <end position="431"/>
        </location>
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            <begin position="443"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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            <begin position="560"/>
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        </location>
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        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
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        <location>
            <begin position="1048"/>
            <end position="1069"/>
        </location>
    </feature>
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        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
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        <location>
            <begin position="1159"/>
            <end position="1181"/>
        </location>
    </feature>
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        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1278"/>
            <end position="1299"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="314"/>
        </location>
    </feature>
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        <location>
            <begin position="698"/>
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        </location>
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        <location>
            <begin position="361"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1310" mass="144904" checksum="6941047E85DCB139" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6J6</accession>
    <name>U4L6J6_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="chain" id="PRO_5004651704" evidence="1">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="267" mass="29274" checksum="4D08259493CCA704" modified="2013-12-11" version="1">MVRVTSLLLQIAVTASVANAQLGGFFKNAFGGAIAQVPLVKQAPETVVAAKSQQLTSENWKSSVNVTIDENASEEDIQEWLLYFTTHPTNGTAQRNVTYWDAVYNDTVVTASKSSPKTRFGKIDCFLADSKDLCHSFFLTNNIPTFYHVATYYQNASVEIRRVPMYRNVTELNEQPAFMSKFLSEKEWKEIAPWTGIFHPFTGAAKGIAPLAGQALVYYEMVPQWVFMIGISLIGRTITSRIVGRNLATLDSPAAAAAPAPAAAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6M7</accession>
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        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX05680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="421" mass="45872" checksum="3C8168EE4DE20908" modified="2013-12-11" version="1">MPSSTFADHPATFKFSTTNGLTITPKGGDAATELSLEDLICVVPSYDQNSYTLCYLARNDSNNPETLMTSPISNPPKPLLDQFLISKLPAHLTNPPTVLVSSASGSNDAESYYNNFVSPLLSALYDTHDLGPPSPIHTTSATTISDTVRDLSKNSEQQTVLLLAGDTAITEAINAAKDHVTLAIFPLGTGNALSTSYHSIKGHPLVAPLKALLHGNAKPLPTFSVSFSEGAKWSNGKPAEPTTGAIVVSWGVHAAVVADAEELRATIKSRERFGVAFQEIAKEMHNFLGQVSIRVDGEWKQVGSGEHFYVLATMCAELEPKFRISPDSRPGEKKMRLIYFRVETPEEVGGMMLKAFDGGKHLDDERVRYEAVEGIRIEVQEKEERYRRVCIDGGIVTLPENGWVEAVVNDKDEGVKLVWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L705</accession>
    <name>U4L705_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L705"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="4769" checksum="DB96693BC09F0EFF" modified="2013-12-11" version="1">MVNTNSFNAAQCGAKIEPWTTEGNINLCFIFLESGTNCNLHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L751</accession>
    <name>U4L751_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Protein bimA acc. no. P17885</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L751"/>
    <dbReference type="STRING" id="1076935.U4L751"/>
    <dbReference type="eggNOG" id="KOG1126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHSPQAW"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
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        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="498"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="668"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="736"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="801" mass="89617" checksum="C9C168D4CD991D16" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7J1</accession>
    <name>U4L7J1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_12188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7J1"/>
    <dbReference type="STRING" id="1076935.U4L7J1"/>
    <dbReference type="eggNOG" id="KOG2450">
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    </dbReference>
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    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07078">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="520" mass="56451" checksum="17A157E58ED7777C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8A9</accession>
    <name>U4L8A9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8A9"/>
    <dbReference type="STRING" id="1076935.U4L8A9"/>
    <dbReference type="eggNOG" id="KOG4013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRAFDQC"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="248" mass="27229" checksum="C41D5C40EA7622A5" modified="2013-12-11" version="1">MAYMPPLLEVCVDNLTDLNSAIDGGADRIELCSSLSVGGLTPTYGLMRHASRLQIPVYAMIRPRNGSFVYSEPEVDMMLAEIGHIINNQDLEGVVLGANLDDGTLDRATLSKLTERAKDCGLRMTLHRAFDLVPDSMVEKEVEFAIQAGFERILSSGGERTAIAGENRLRRMVAAAKGRIEIMPGAGITLENVKDVVKIADFEWIHSSCSESLWSEEGQLRKLGFVDDKVRFTSKAVVSRMKAALKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8T4</accession>
    <name>U4L8T4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8T4"/>
    <dbReference type="STRING" id="1076935.U4L8T4"/>
    <dbReference type="eggNOG" id="ENOG502SY9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5368716at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="28585" checksum="24D8B0CF3B808B56" modified="2013-12-11" version="1">MGSHTPQPSSVGTYSFMPYPAEYAFSPGMTYPPMPPMDHPGSPYSPHPHFPSNLAFHMGHPPPSPITSHSHLPPSPPAPSSPGRSDRERDREHDRERERERERDRVSTETKMIRQLCTTIAKMQGTMKDLAERQTEILDRMSLLEQRSERANESIERILENTEMAMEDSKSIRTRVEDNESQDAFETRLTDLMDNVVEKLIGGIGQELKEIKKMVNNVDRYNSLRDPFALAQRVSDADLLGEEEQEEVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8W6</accession>
    <name>U4L8W6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935839">
        <property type="protein sequence ID" value="CCX13415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8W6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="29" mass="3276" checksum="3DB64314EA24447D" modified="2013-12-11" version="1">MHLRLSSSSGRSTTSWVFFELAEDVGYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Y3</accession>
    <name>U4L8Y3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_01676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Y3"/>
    <dbReference type="STRING" id="1076935.U4L8Y3"/>
    <dbReference type="eggNOG" id="ENOG502S5Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLTIINY"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX15401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9901" checksum="8A6E2A239BA76EC1" modified="2013-12-11" version="1">MALHSAGAVREKKQSMAELKLRRLTELNARLREDLDRPRIKVSDACQSMINYTRTTKDFMVPSTWGNVDKREDPYAPQQTGGCCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9B0</accession>
    <name>U4L9B0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9B0"/>
    <dbReference type="STRING" id="1076935.U4L9B0"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="207"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX15582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="379" mass="41162" checksum="66FEF8D327180EA0" modified="2013-12-11" version="1">MPPTRKQSNRTRSPPPTPRRTKRVKLSKPVPNTEETPAQTEVPEAPPAAHNEPDSIEQAADPETNKEKTDNEELPTVESIPEPTTDTTNTSFNVVVGNTQAEPTLTSTEDEQRKDEPKPEADEQKDEQKDKQPKPSAKAPQEPSLLRPLEFDDGLSSELSSLPDTPAPEPAPESKPESATAPAPTESKAESNVDSKPDPTSSPAWPGWCTIESEPAVFNHLLHSIGVSGAQVTELYSLDVSSLLALGRCYGIIFLFRYLPSSASYADLPCPPGIWFANQVTANACATLALLNIVFNSPVTLSPSIKAFKEFSADLTPPLRGLAVANNERIRDIHNGFGKKMEMVDADIELAEAAGTRLAKGAWKEEETEEGGRSILWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9S5</accession>
    <name>U4L9S5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Suppressor protein SRP40 acc. no. P32583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9S5"/>
    <dbReference type="STRING" id="1076935.U4L9S5"/>
    <dbReference type="eggNOG" id="ENOG502S112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENNSGME"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="321"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="396" mass="42850" checksum="5F598861ABD9D819" modified="2013-12-11" version="1">MVKDKKTTKATKASEPKVDARLYTLVGSFLKDAGLSSTVKIFEAETSSRKVEKSSKLPAPKSLEEALVAWEKTAEKPAAEDSGDESDSESSDSDSSDSDSDDDTDSTATLAEEKKEEKVEKKDDKKTEQKAEKKEDSSDDSSSDSDSDSSSSSDSSSDSSSDSSSDSSSSSDSDSSDSSDSDSSDSGDEKKDKKKAEKKEEKKAEVKKAGKKQEKKEDSDSSSSDSSSDSSSDSDSDSSSSSSSSSDSDSSSSSDSDSSSDDDKKKTKKSDKKGKKTEKKEEPKVEEKKRKRDPSPAPAEKKAKVDDEEESEKPKNSTAKRFSRIDLKKISYEDESLMNNGYEAAGFAENHYAARAHADLIVTKGKGFTKEKNKKKRGSYRGGAIDFETKSYKFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA07</accession>
    <name>U4LA07_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Pre-mRNA-splicing factor prp1 acc. no. Q12381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935331">
        <property type="protein sequence ID" value="CCX07019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA07"/>
    <dbReference type="STRING" id="1076935.U4LA07"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="834"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="933" mass="104992" checksum="4CF282C31286FA8B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB14</accession>
    <name>U4LB14_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase, mitochondrial</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_06943</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LB14"/>
    <dbReference type="eggNOG" id="KOG1038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWFEVDM"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.260:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="342"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1266"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1309"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1284"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1309"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1386" mass="155882" checksum="AEDC2DA606C5DC9A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBT6</accession>
    <name>U4LBT6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to ABC transporter B family member 5 acc. no. Q9SYI3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_02861</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LBT6"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFVAYAT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF18">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="802"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="120"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="442"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="762"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1096"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1335" mass="144229" checksum="E34E4570C51FC292" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD05</accession>
    <name>U4LD05_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935398">
        <property type="protein sequence ID" value="CCX29989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD05"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="10734" checksum="34F88676E954151A" modified="2013-12-11" version="1">MEEHEERVQEGDTKALAPPPKQGPYSEESRRHQKRATWAEVVATGGVNIPAVFGLLGLNLGGKGAHRSRNRRTGRPQKARMEKGGMEEGGTEGGATGGKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD20</accession>
    <name>U4LD20_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD20"/>
    <dbReference type="OrthoDB" id="5476607at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="313" mass="34407" checksum="6A202244ACBBC4DD" modified="2013-12-11" version="1">MSPKAASLLYSPPTCPSADLFDLRLPFIKTESSRLHPTTSILSLPKMTLANITNRGNRRAAVPRVNINVNNASSEVNTPVPSSENAAASLPSSPIAVHQNPVDLYHLALSLLQATHSLSSDDMKVTWYRPLEGVKCWGDNYNVPAGEINEVVSSGSAIGKLVMKNLNIVVDVCMEQIKRKVGDAVGPRVLELQDAEEDRINRLKGVTRELFCATGDIEDEQDRLKYNETTDDEQEEEVGDISSSDISEAGSSSDEESDGEILRRMQKVQEYKPAPTVPSSPMKRKAPKKGSKRAPKRRVRFQEPKKKAAGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD62</accession>
    <name>U4LD62_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cell growth-regulated gene 1 protein acc. no. P56553</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_08051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD62"/>
    <dbReference type="STRING" id="1076935.U4LD62"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAGTMRY"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX30059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="315" mass="34469" checksum="BEF9B39CF4E70528" modified="2013-12-11" version="1">MSDEHVETISINEPYLNITCALGEGPFYDAKSNTLRFVDIIRKELHTVNLEQGPGSHAVLKLKDSVGVTANIAGAEHPDNVIMVAAKYGFAKLNTGTGELEYLKRVYEGEKAERMRFNDGICDSRGRFWAGSMNDFHVGEPQPEGTIYRYDPSGTLQVMIDNVTIPNGMGWSPDERTMYITDSPTRCIHAYDYEPIVGSISNRRVFYSLPEEEKDTVLDGCTVDTDGNVWAAVHEGGRVIKISPEGKVVKQVKLGAWRITCPAFGRGGEMFVTTAGVEEGENAPEGSVGHGAVWRFETGAKGGHERNMFGVGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD68</accession>
    <name>U4LD68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Cytochrome c oxidase subunit 6B-like protein new16 acc. no. G2TRP6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935700">
        <property type="protein sequence ID" value="CCX12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD68"/>
    <dbReference type="STRING" id="1076935.U4LD68"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="168" mass="18997" checksum="E9264F044DF1AFB5" modified="2013-12-11" version="1">MAGFWHRRRSSIIRVRASPFLTTNEPTAQPTTPKPSNPKLLKRSQSSDQLAAMGLFGTSTTKSTEPETKIAPNRSQRAKCWEARDAFFECLDRNSIIDSVKEDKKAKEVCGGENVKFEKECVASWVEYFKKRRVMEYNRDQMMKGLQNEGAQQVAIPDPVGQAQVSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDK4</accession>
    <name>U4LDK4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935434">
        <property type="protein sequence ID" value="CCX08890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDK4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7227" checksum="F4F735833EDEDF5B" modified="2013-12-11" version="1">MGFIDSKKVHCSFKRRIPARLGSPMQLRSLSRPDGLLEMSRPYDNDHLDAKHIISGPKPMAYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEI9</accession>
    <name>U4LEI9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Aminopeptidase N acc. no. O57579</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935395">
        <property type="protein sequence ID" value="CCX29967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEI9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="96" mass="11233" checksum="76D7BF27C6026E1D" modified="2013-12-11" version="1">MEGWNWRMGIRRAMVYCVCVGAGGETIWSLFWNRFNRINFHAEHTSSTRTTDICGIMVLQQYAQLEIAVTFIVKELQVHPNELYRRLQNISLTVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEQ4</accession>
    <name>U4LEQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Benzoate 4-monooxygenase acc. no. P17549</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEQ4"/>
    <dbReference type="STRING" id="1076935.U4LEQ4"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="562" mass="64004" checksum="3F54FC4C14C18A97" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFA1</accession>
    <name>U4LFA1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFA1"/>
    <dbReference type="OrthoDB" id="10308346at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="430" mass="49224" checksum="048AC18251AB94B4" modified="2013-12-11" version="1">MTRSISTASSVYSRCFSPPHPRQTETPPTPLGFFSLENSNIEHPFQFPSSKHRTTEVGNDYDSGYGRSYPASPTFASPKFSEYYACNGNPWNENPWEDIHTESCKLEIPLVAPRVPRPVVQKGKTTKPRFLIDGTRAPPSKNCIPWLANWDYSYRQLDTYEANRNVEHLSNGWCYPEEQDSECEIEEWEETQQEEISAKNTGSDRSESALIHGPKMTLARRWMKAANLTPRRPSLESSLPPPLELAKAKDWELRRHLRNRPKPRTGEEVFREVVLQMDWTHLPISEQDLGLTSASCLAVADRICHMLSEPSDLDRLSGDAIFDAVHASVKRLVASRPGFDFVSRYNYEYDERIPDMKFNLGRYVDFKGFPFGINDEVVGQRVWVNPGWTDVGLSDAARKTLGPEWWIDRSTGKVRPSRIGRRRKGDDLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFD8</accession>
    <name>U4LFD8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <ecNumber evidence="4">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PCON_09192</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 100304</strain>
            <tissue evidence="24">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4"/>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFD8"/>
    <dbReference type="STRING" id="1076935.U4LFD8"/>
    <dbReference type="eggNOG" id="KOG0637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="22">
        <location>
            <begin position="623"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="23">
        <location>
            <begin position="813"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCX30789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="907" mass="97946" checksum="AB9F6083D13D8900" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFP1</accession>
    <name>U4LFP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to WD repeat-containing protein wat1 acc. no. O74184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935543">
        <property type="protein sequence ID" value="CCX10463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFP1"/>
    <dbReference type="STRING" id="1076935.U4LFP1"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX10463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="307" mass="34442" checksum="4B0E37B9148F5B75" modified="2013-12-11" version="1">MSVIMATAGYDHTIRFWEALSGICSRTIQHTDSQVNRLCISPDKRFLAAAGHTTVRLYDIKSSNPNPILQFEGHTNNVTGVGFHCEGKWMVTSSEDGSVKIWDTRTGAVQRDYQHGSPVNDVVIHPNQGELISCDQAGNVRIWDLGENKCTHQLIPEDDVPVRSVTVATDGSMLVAGNNLGNCYVWRMIQNRDVTQLLPVTKFQAHQKYITRVLLSPDVRHLATCSADHTAKIWSVDDKKFSLETTLAAHQRWVWDCAFSADSAYLVTACSDHYARLWELSSQQIIRQYNGHHRGAVCVALNDYSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG50</accession>
    <name>U4LG50_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="290"/>
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            <end position="56"/>
        </location>
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            <end position="176"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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            <dbReference type="PubMed" id="24068976"/>
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            <strain evidence="4">CBS 100304</strain>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="246" mass="27719" checksum="ADDDAD6DF19977E3" modified="2013-12-11" version="1">MAASSAGFQQRISDDVEKIHVMIKEDELEKIIEWISPLDPQKRHDDIKSKRLHGTGAWYLKKPEFIDWCNESQGENSGDESKPILGCYGIPGPGKSVMARPQVKASIEAAFQDLSYDITVEANDDDIRIYVLHQLDMDVNYRDMDEAFKKAIIDKIVETADGIFLLPALQIQTVLEKTSISKRRLALNEMPKKLHKAFAATIERIARQATAKSIPGMEVLKWTFLAKRQLSIIELRHALAATNSTA</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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            <begin position="46"/>
            <end position="82"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9616" checksum="83CB325C8B7FC461" modified="2013-12-11" version="1">MPQWAKYLQLQLQLQLQLQLFFNSFLSIRRNDKFDKFPRRIVMRTLKAAGPAPHHSAHNTKNNSTGNQLNQPAWLPQSETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGN5</accession>
    <name>U4LGN5_PYROM</name>
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        <submittedName>
            <fullName evidence="12">Similar to Histone-lysine N-methyltransferase ASH1L acc. no. Q99MY8</fullName>
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        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="238"/>
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        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="654"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX31264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="786" mass="86810" checksum="1D73A03BDD3A5FFF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV8</accession>
    <name>U4LGV8_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX15548.1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="223" mass="25941" checksum="8836112575135C91" modified="2013-12-11" version="1">MESEENKHNEHTDHSEEGEESEEGEEGEEGEEVSTAEPEKVRELLGVTDEEFEDYCKCAWEKVIWRVKDKTPPLEWEIRNIEELSTQIQGKIEQGRGKLDVPHQWFLLVALISACRTLYNYTIKAPLLVKDQTPSVMWDLMKIDVANTLSKKAVKKAAKTVYKSYGHGDFPNVNKLKEKNEMVKMLKTSLNYPLDLDDRFYAWILFYTANLQRKAIVKEKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH02</accession>
    <name>U4LH02_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PANTHER" id="PTHR42339:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="295"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="392"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="523" mass="57036" checksum="9576105823C0FD87" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH27</accession>
    <name>U4LH27_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_10761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH27"/>
    <dbReference type="STRING" id="1076935.U4LH27"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNMERER"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="456"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX31414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="740" mass="85305" checksum="9F375FEB5153885B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHF6</accession>
    <name>U4LHF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UPF0308 protein C9orf21 homolog acc. no. Q148E0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935626">
        <property type="protein sequence ID" value="CCX11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHF6"/>
    <dbReference type="STRING" id="1076935.U4LHF6"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIAHEQI"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="346" mass="35715" checksum="77E8E17F012831A0" modified="2013-12-11" version="1">MAAPNTPPAPPASTPVTSLPTDTLPSADAISRALSLALYPSAPGTSSSSHRPSSHSKRASVAGPIPGAEIQPAQPILGATTMEPPIGTANNGAGVAPAVPKAAAETTLSALTTSSPIVLTVFIRHFYCTSCHNFLEAMAATQELSQAALAARGVKLVIVGCGQPEVIEEYRKSLASAMGRRGANGNPQPTKTVQGEQNGAGVAAETPQAATKASSTGPEWEFYTDPEGAVYDSLGMTRTMSLGKKPGYIRDGMLAGIIKGVIASLKGGVTKGGNPTRNGGEFLWVNGNLVYAHFMQNTRDHLEVGQVLKLLDDHTVHTQQQQGESVIAHEQIVPEGQTVGVVAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI69</accession>
    <name>U4LI69_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI69"/>
    <dbReference type="STRING" id="1076935.U4LI69"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="511"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="833" mass="94548" checksum="11483627FC7CDB03" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJH8</accession>
    <name>U4LJH8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJH8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="44" mass="5133" checksum="692B9160A8965E59" modified="2013-12-11" version="1">MEIEFQVHTYPSFHRLLRSQNGGTRFLTLASTLYPKALSFTPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJJ2</accession>
    <name>U4LJJ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TPR repeat-containing protein C19B12.01 acc. no. O36033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJJ2"/>
    <dbReference type="STRING" id="1076935.U4LJJ2"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNRYARA"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="921" mass="102788" checksum="CBDE3FECF1A61343" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJS2</accession>
    <name>U4LJS2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJS2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="120" mass="13216" checksum="78652B5A0526B88D" modified="2013-12-11" version="1">MVVPLASTAARFFDQASIPTSISYTSVFSSSFIFSCPYTPSYSESLACPRSSKSGAMFVFPTPIVVNIFAQCGEGGKSTQVISGLFRKPVQGRQIISNWSSRYCAHLSDIHKLHRPYHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJS4</accession>
    <name>U4LJS4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to SVP1-like protein 2 acc. no. Q5B464</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJS4"/>
    <dbReference type="STRING" id="1076935.U4LJS4"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEMLHRT"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="365" mass="39983" checksum="22FB7BE9AB3CC168" modified="2013-12-11" version="1">MNTRPQLATADRRIALCANFNQDSTCFSVGVDNGFHIYSSDPCELQVTRELGGGIAVAAMLGRANFLALVGGGRDPKYAQNKVIIWDDAKKKAVISLEFHSAVRQVRLTRTRIIVVLIGHVHVYQFSSPPTRQHVFDTYDNPLGLVAISARTLVFPGRTPGHVQLCDLASGNISIIPAHTSPLAALCISPQGDLIATASEKGTIIRLYSTDTCSLITEFRRGMDKAVVYSLAISPNSQKLAVTSDKHTLHIFELPTRPHSSPRFSNPQDQHHVNGENKRWSLLGRLPLLPKYFSSEWSACHAEFEGGGVANIGWVAEDTVVVVSIGGGKDGLGEARWEKFVLVEAMNGNGEEVVREGWRRYLDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKG5</accession>
    <name>U4LKG5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKG5"/>
    <dbReference type="eggNOG" id="ENOG502S5TP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5340163at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="777" mass="89635" checksum="BAFFC701E5E66A9D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKL8</accession>
    <name>U4LKL8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_13323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKL8"/>
    <dbReference type="STRING" id="1076935.U4LKL8"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMYVIHA"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651679" description="C-8 sterol isomerase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX32483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23624" checksum="362C7D50E44AD8C4" modified="2013-12-11" version="1">MKTLHLILLVLPVIFYYLDALLPKGYIFDPVKLQELSKISIETGNGNTTQVMSNLVALLQEEYGSQHVNGMEMDKWFFNNAGGAMGSMLILHASISEYLILFGTPLGTEGHSGVHLAHDYFTILSGEQMRLAPGEIEPTVFRPGDQNYLPRGEATQYVLNGWALELAQGWIPSMLPFGFLDTFTSTLDFYNLWKTVYLTGVNMVGQLLIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLJ8</accession>
    <name>U4LLJ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Laccase-4 acc. no. Q02081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLJ8"/>
    <dbReference type="STRING" id="1076935.U4LLJ8"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFWLYHC"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="84"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="207"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="444"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="617" mass="70163" checksum="CB5DF297BD6801E5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLM5</accession>
    <name>U4LLM5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to FMN-dependent NADPH-azoreductase acc. no. O07529</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLM5"/>
    <dbReference type="STRING" id="1076935.U4LLM5"/>
    <dbReference type="eggNOG" id="ENOG502QQY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNSHAGR"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="79"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="321" mass="36475" checksum="47D975982E7551C5" modified="2013-12-11" version="1">MFFPLRTASTLLRPLSRTMTTLTNGASTPAMDPYYDPEISAKYRPFILPAEISEKDWISELELDSVTELSKTTENNRLKFLVLYGSLRHRSFSRLMAYEASRILYKLGADVRVFDPTGLPIKDDDQHDHPKVQELRKLSAWSDGHVWCSPEQHGNLTAVFKNQIDWIPLQTGSVRPTQGRTLGVIQVNGGSQSFNTVNSLRILGRWMRMWTIPNQSSLPAAWTQFTEPDAEFGGNRLMPSGNRDRLVDCMEELVRFTTYYRPYAEGLVDRFSERKERKQKEEKLAKAKAEAAKEAEEKAAKELEEAQKVAGQEKEAVVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNB9</accession>
    <name>U4LNB9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UPF0586 protein C9orf41 homolog acc. no. Q80UY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNB9"/>
    <dbReference type="STRING" id="1076935.U4LNB9"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSHHATE"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="414" mass="46041" checksum="8779ECB40B888280" modified="2013-12-11" version="1">MSTSTPPDPMPPATSSPNRLPLLLACIVLIAAFQYPLLINWVSSRGDNATAGEITSAVGQRGKALAALAGFSRYKQRSQNTIHEKRSKFNKLPWAQKKLTNYPHKLSLALQTVEENSLLAKDIVTFGLEAYNISAYELRAYMKMNRTAGDHSSVVQALKHYVRDWAAGGAHERDAVFPQILKAMEDRGGRVLVPGAGLGRLAYELAAQGAEVTANEFSVYVSMAYQYMMSLNGSNPRAEAGMYKFHPNVNWWSHQRDTAGLLKGVEVPDILPDEKVLKRMKMVDGDFVTMFLPQESEAFDTVVTLFFIDTARNIVAYLETIHKLLKPGGWWINLGPLLYGTNPSIELGLDEVLEVTKKLGFELLPIGEEWGTETFPDDERWAGKVRGTLAGYSWDPDNLSRNAYQAQGWIAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNU4</accession>
    <name>U4LNU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Exocyst complex component 3 acc. no. Q6KAR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936189">
        <property type="protein sequence ID" value="CCX33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNU4"/>
    <dbReference type="STRING" id="1076935.U4LNU4"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6197" checksum="D1B462A0DB3EE316" modified="2013-12-11" version="1">MDETDAIAVRLPDILRHPEDLDKVAALKADFARKKAHVDTQLRAGLESQLEVTEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNX2</accession>
    <name>U4LNX2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNX2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7474" checksum="92CBD8845D403E86" modified="2013-12-11" version="1">MSSGRTVPEHRGVSTNSALVFPRHLPHLTIIQADIDLDCNDNPSSGSVYKVRSQSLATKSSRFDNKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP59</accession>
    <name>U4LP59_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP59"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="10673" checksum="57F51909E5024AFD" modified="2013-12-11" version="1">MKHSLTDVNGAGRASYPMVKKSDKFIIEIRKDTDPVKNQRISQGLKKHNTLDSIVNPLKICTISLAEVAGHATGHVISGGLLEDAGNKYAEGITSTQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPC1</accession>
    <name>U4LPC1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="HF936058">
        <property type="protein sequence ID" value="CCX33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPC1"/>
    <dbReference type="STRING" id="1076935.U4LPC1"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="12">
        <location>
            <begin position="907"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="790"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1041" mass="115946" checksum="0097AE70AC736BC2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPK1</accession>
    <name>U4LPK1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPK1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="21" mass="2383" checksum="BC0ADC5B9C7851E2" modified="2013-12-11" version="1">MFNSTFPEGQAEKRSLLNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPK5</accession>
    <name>U4LPK5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Transcriptional protein SWT1 acc. no. Q12104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPK5"/>
    <dbReference type="STRING" id="1076935.U4LPK5"/>
    <dbReference type="eggNOG" id="KOG4689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="230"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="585" mass="64116" checksum="E980E457201638E5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR45</accession>
    <name>U4LR45_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to GATA factor SREP acc. no. Q92259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR45"/>
    <dbReference type="STRING" id="1076935.U4LR45"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX29771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="551" mass="56755" checksum="CE9FD4DD0CE0BE82" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR56</accession>
    <name>U4LR56_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to L-sorbose 1-dehydrogenase acc. no. Q47944</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR56"/>
    <dbReference type="STRING" id="1076935.U4LR56"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVTATHE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="658" mass="72061" checksum="DA5F973465EC8EEB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRF7</accession>
    <name>U4LRF7_PYROM</name>
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        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_02654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRF7"/>
    <dbReference type="STRING" id="1076935.U4LRF7"/>
    <dbReference type="eggNOG" id="KOG3134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAVERCF"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
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    </dbReference>
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        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="343" mass="37088" checksum="9F94373208EE0123" modified="2013-12-11" version="1">MSPSTSAPAPTPAPGLVQAPSIPIPSANLSSAAPLASSTTSHSAAHSAAPPTSTAPPTSQTNPSTQTQADPLFICIECSYPVQSLYTAYSSADDKSLGRGVRLTQCPRCKRFADKYVEHDFVVLFIDMVLIKPQVYRHLLFNHLGRTDDKLDGSIKRLGVLLLLFDVYLTWARIEKSIPTSHPQILSQPIVVQYLFFRTPPPFSPLLRALRFCFCLTESLLFHATIRFLSFYLLRFPRPNAVSTALLVSSCTKLFPILMVIWKYDVPAAARSVGWAVVVNNVEALRILLNVDYVRAAALTGAGAVVRAGVSGAVLRAAGLGGEETGGGWEGWGEWVGGMMGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRM2</accession>
    <name>U4LRM2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_04319</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRM2"/>
    <dbReference type="STRING" id="1076935.U4LRM2"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="461"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="759" mass="85741" checksum="19B8A26CCE3CA647" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRQ3</accession>
    <name>U4LRQ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRQ3"/>
    <dbReference type="eggNOG" id="ENOG502S8Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5406607at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652605" evidence="3">
        <location>
            <begin position="23"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="692" mass="77227" checksum="CBD8042C1685D2C9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRS3</accession>
    <name>U4LRS3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to PREDICTED: uncharacterized protein LOC100778909 [Glycine max] acc. no. XP_003528986</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRS3"/>
    <dbReference type="STRING" id="1076935.U4LRS3"/>
    <dbReference type="eggNOG" id="KOG4585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWRAIFF"/>
    <dbReference type="OrthoDB" id="5421058at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF273">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="37"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="249" mass="28389" checksum="A401323B02D6D850" modified="2013-12-11" version="1">MIRLPKPDKPKPNFFPPEIKGNPEFWPFFKDAIGVADGIHIPVKKVPTDHLNRFRNPSGGLSQNVLGICNFNFLFDFVLPGWEGFATDHQVLKFALDHGGLKVPDGKYYLVKSVDARYGGQKELLPPYPGVSTLCVKKTLHHTLRMVIDRRFGVMKKRFKILMTGGGYDINTQAKLVYALAGLNNFILVYCGKEDMEGWKEEDDDDDTRVRRENAVDEQPVHQGPEDAAMMAMRDRMARDMWDAVYEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS71</accession>
    <name>U4LS71_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c acc. no. O13899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS71"/>
    <dbReference type="STRING" id="1076935.U4LS71"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HDKRMLV"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="365" mass="40221" checksum="99AEB09EBD251105" modified="2013-12-11" version="1">MSLLATSLRPCGQMRLVSSSLRRFKTTVNTPKAPPAFAFAFDIDGVLLHGSTPLPGAKKTLDYLNHNKIEYLLLTNGGGLSEAHRVQELSRLLDVPLSTQQFVQSHTPFQRHASSIPRVLVVGGKKDNCRHVASGYGFKDVIIPADVIHTHPAASPFSEAGAYENIGRTLKGGEKVDAIMVYNDPRDWGSDLQVVVDVLLSKDGEIGTRRSTKEVLEQGHVPIYFSNPDLWWANEYSLPRLGQGGFRAALEGVWRAVTGGELKAETIGKPHTETYRYAEEVLMRWRKERTGDAEIKRVYMVGDNPASDIRGANGFTQGKAEWVSCLLRTGVFRDGEDDAGAHHIADNVANAVMWAVEREKNMGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSS1</accession>
    <name>U4LSS1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSS1"/>
    <dbReference type="STRING" id="1076935.U4LSS1"/>
    <dbReference type="eggNOG" id="ENOG502S8GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFYGEWG"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="15305" checksum="C4D218971294C08E" modified="2013-12-11" version="1">MTEPMIDPEITGASHDATASDGATKSTPKVTPYQEKVYNLLRQIPSGKVSTYKQLSDVLDSSPRAVGGALRKNPFAPEVPCHRVIATTGYIGGFMGDWEKVPSGVNCDKKRQLLSDEGVEFDEKGMLKDKSQLWGEFKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT45</accession>
    <name>U4LT45_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT45"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30557" checksum="FABD4E7FACE4606B" modified="2013-12-11" version="1">MGMAQIADHIVAKGNVKFGSQAAIKAVINQSQGLATKFLTDRDKKDFQNWFIERYRILMDLGAIITTSAGNWGDTSDISSTELVPQAWAGEKMLLIVVGNAGPDEKRTGNSQPGEQVTVYAAGTDIYCAKGSVDSGIFRGGTGTSQASAITAGLSAYFLGLPYDLVDPTNNKNPFDSLVGVKLQNKMIEVLKELAAERQTGSEKQVHNGYHRDRKCPNPLHKTLQDCKTSVRKCVKALIGKQGPKKRSADDVVVSKDSVKEINNFCDAINNKSMSPKQEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT75</accession>
    <name>U4LT75_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT75"/>
    <dbReference type="STRING" id="1076935.U4LT75"/>
    <dbReference type="eggNOG" id="ENOG502SKZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5413829at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="29338" checksum="02DB6F2C12C70BA5" modified="2013-12-11" version="1">MAATSTNPHLTDPLLAPFLIPTFTPTSYLNSILPPLLPPSIPTTSHPPTQAQSQHPLATSLSASALPLSDLSSSTTTLLSTLSHQLTRLLTTLSSLTDDLLRLSPRLSYSIDLLRSDVLSLAEELNGPIAATVAGSGHRPEGLERLEISGGGFWGAMDWSLDVPEGSQSLQSSQTLSSKDKGKKDVVGEVVYLLAAGDVKGAREKVEGLRLLASVFEGTVEGPARVAVVERLDERVRMEEEKGMPRKLGREVKRETAGEAGGFNGLIESLKGLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU05</accession>
    <name>U4LU05_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_14310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU05"/>
    <dbReference type="eggNOG" id="ENOG502S3BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFREANL"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="185" mass="20392" checksum="95A1019AE7B0F7F2" modified="2013-12-11" version="1">MSDSAPTEPTPTPAAPAAEQPKRYLTPPTDAPANNFAREGQVGLDDAVKTITLDDFKKVHLQPCFREANLYGMGAGFGVGGLRFVFGGNVARSCNWAVGGFILTTIGCYERCQYQRRKEKDGMRRAAEIIEKKRIEREAKIAEIRARKAAGLSGSSAVPEHTQVTVQPEGMEKIQGSQRAWYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU32</accession>
    <name>U4LU32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU32"/>
    <dbReference type="OrthoDB" id="10669116at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="498" mass="53649" checksum="987BA1E1C15FE9AC" modified="2013-12-11" version="1">MSTAQQTKPRSAHLSPTPPHKRARSPVAQSTRRKLSPLLPQPGAPRTALDRTVSFDHNSHTTTTTMITPTTTTSFSIAPQQQQHPAISSQHSFPPPMTAASSFTSTLPPSLRAESSFSSAIPSLSAESSFTSTIPSLSTSHSFASGFTAPYPPPYPAASPPTYTPLPATVISTASPAILADSLTQAQALISHLQTLTSHQRLLQHFLQLDLAELRARLKVEEDIAGAQVRVLRGRAQTGSPGRGTAERSLKNLRDARDARLRISRGTRRVPGEPGAATNTGEPGEPGGHRGVRVSRGDPLETSHLKQKLKKAMAENRELRRVLSHPHPGPSLQNHNHNPTVSLVSDLSVPLVPASLVPLRPLSPLVHTPPASRNTGGMTSSSVMSSGARAARERQHIMSAAIAGYVVDQNMRIKERDSTIELDEVDEGDEGDEGGEGKRDRDRESTPTPGKRGAGPGRKAKAKTNVKERGKGRERKEFKEKEKEKERQRVIGTPVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU38</accession>
    <name>U4LU38_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_10604</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU38"/>
    <dbReference type="STRING" id="1076935.U4LU38"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPGDKFV"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="341" mass="38252" checksum="6DA4AEAEE82F2F14" modified="2013-12-11" version="1">MEEYNDTHRALVQAFLARSSMTGEELLGVVTAIHGVENPEEPTETTLEVCKLLISRINTALAPFDFEIRSTRDQITRTEIFAFVNINPDTIIQGATHHSADEIAFFRRLLDAMFETNNQYKAEVMAVSSNEALNLNKNPRVQATQATQADGGEDGEQTAQTGEGQGPGLTMKQAQEALEMFVDEEWLRKSRGGWYTLAPRGLLELSYYLQQTYNDEADPEESEDPDTPPIKRIKDCFACREMITVGQRCDKLDCPIRLHDPCAASFFKVNKNGKCPGCKVPWTGKELVGEKAAAKLKRRAGGADRMRSTQSNRRQSGVSRRDSEDEEEEEEETTMVNDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU46</accession>
    <name>U4LU46_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU46"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8512" checksum="8D52D61F0906207B" modified="2013-12-11" version="1">MSSAQRRFVAHLLELRDCETSAKTTGSRMRLCLYRASVGLLPHLETFSSTSIEPPLLPHCLMYASMKFNHEPCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV65</accession>
    <name>U4LV65_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Protein stu-1 acc. no. Q7S9L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
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        <property type="protein sequence ID" value="CCX34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV65"/>
    <dbReference type="STRING" id="1076935.U4LV65"/>
    <dbReference type="eggNOG" id="ENOG502QT5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHGCLLW"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="13"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="292"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1278" mass="139763" checksum="44A7F6EB50906201" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV83</accession>
    <name>U4LV83_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Zinc finger transcription factor ace1 acc. no. Q9P8W3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935806">
        <property type="protein sequence ID" value="CCX32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV83"/>
    <dbReference type="STRING" id="1076935.U4LV83"/>
    <dbReference type="eggNOG" id="ENOG502S2AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="900" mass="99374" checksum="886DB0B8E7AEC4AB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVV9</accession>
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        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04593</name>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVV9"/>
    <dbReference type="STRING" id="1076935.U4LVV9"/>
    <dbReference type="eggNOG" id="ENOG502QVRG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCPFVGQ"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55175" checksum="B68B5CC57FED46D4" modified="2013-12-11" version="1">MLLSLDPASGDSNSAWKESIKTTSVFTSAAGKAVDLHDGLSGYKEFGLLGQQLEVVDPVTCTIEITPADEDGRVFLNGDAPLSAFICGVQGAGKSNSLAVMLENFLLANPDINSLPVPLTGLVFHYDRHAPFACEAAYLCSHLPVTVLVPPSSLRSATALYSSLPGASANLKIRALRLREIDLNITRMLSLMAVDQSNDNPPLYLEIVRKILRFMANSDSGFRYGVFKTMLGNEKLSPAQKGPLNLRLEILESFMEGRAPSEKAGDLWGQEGGLVIVDLTDPFVDEATACLLFEICLNLFLQRHVKGSVIALDEAHKYMTATPSALKFTDTLLSTIRQQRHMGARILIATQEPTISPKLLDLCSFTLVHRFTSPEWLTFLKSHIAAAGQAQDRAELMKRIVELDCGEALLFVPGGVMVGKEQMKEESREILGDIRNISGMKTFGKEMEEALEKKKEMGVLEKLGMRYLKVKIRKRVTADGGRSVMAVAEVELKKVFSGRQKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWF1</accession>
    <name>U4LWF1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWF1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="18012" checksum="83A4548B52CD430B" modified="2013-12-11" version="1">MDLILLHLFILSRTRPGSRVHEAKSTGLQRINFDNANYFEIPHGNLHSESVYNKIARYPPFNPSIHDNNKRPSYFRRIHFPCCASGDFKHRRSVQLHHGDSPLSSPLFSQPRQFFGPEHHQEYMIIVASPQAPHSSAHKGPYTRPGVCYRLRPGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWJ5</accession>
    <name>U4LWJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Metaxin-1 acc. no. Q9HE00</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWJ5"/>
    <dbReference type="STRING" id="1076935.U4LWJ5"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNAWLYT"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03054">
        <property type="entry name" value="GST_N_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="79"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="318" mass="35228" checksum="ADEFE45931BF10AC" modified="2013-12-11" version="1">MATLEKQHSQSGPAQSQSKSWLPIPEPVKKLFDSFPVVTYPAQQLPAGCPRNEKLPTLWIFTKGDGLDANGRELMSFNPSCLKWQTYLRLSSLPYRAVPSSNHSSPSGALPFLIAPENSETIPSNKLMQWIKKHGNPPEEDLEDPEIKALLALVETKLRDAWLYTLYLTPVFWSLTQDLYTSTSSSLARLYLSHELQQAARQELANTRPLLAHSLLTAPLSYTASYSSSIAPSATGATSPAEEIYADLESALQALETILGDDNWFHGADRPGYFDAAVFGYVELMGMEGLRETRLGEVVAGCRGLQRWREGVRGRAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWL5</accession>
    <name>U4LWL5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ankyrin repeat-containing protein, putative [Penicillium marneffei ATCC 18224] acc. no. XP_002144344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWL5"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="141" mass="16602" checksum="9B9EF6705ED0C4A9" modified="2013-12-11" version="1">MMRELLKQSIIALPDVSDEIRGHLLNKKQKQTPLDLNEAQQLLERVLGNIAKSRTIYVCIDTLDEFEDMNRRDFLQSIRRILTSIDRQVLVFVTRRLHIENVNDIRKYVTIKVDQDNNKDCMNEALRQEILNEIVASLHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXA6</accession>
    <name>U4LXA6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936512">
        <property type="protein sequence ID" value="CCX34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LXA6"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MQAFCIA"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34313.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="607" mass="65130" checksum="56800746F5861F7C" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4LY98</accession>
    <name>U4LY98_PYROM</name>
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    </protein>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="20"/>
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            <end position="16"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="11407" checksum="5EBA23C3272E2274" modified="2013-12-11" version="1">MPNELSSVTPNGTNKPSEVRMPNGTVLITLKTLDLNQDLGEICMYVCTCTLKTPVRNKKCLKPRLPRAPGILPLKKIFFFFWFRKIQKSHQNSSGCKLGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYG6</accession>
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        </recommendedName>
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            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04564</name>
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    <organism evidence="14 15">
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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            <tissue evidence="14">Vegetative mycelium</tissue>
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        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="120"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
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            <end position="570"/>
        </location>
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        <location>
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        </location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="627" mass="68688" checksum="023E34D7B321961B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU54</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S5P0">
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    </dbReference>
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        <location>
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            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="524" mass="57470" checksum="62209DA37F7D5717" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUQ0</accession>
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        <submittedName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUQ0"/>
    <dbReference type="STRING" id="1076935.U4KUQ0"/>
    <dbReference type="eggNOG" id="ENOG502SRAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGFWIER"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32994" checksum="FF2ADD4F4E1E1D84" modified="2013-12-11" version="1">MATLTFAHTTNDNSAPWLISTHIFTIITSYLQPSPADTAVLSASDAAQKLDSLFPTNRSGIDGDEEKKESPGSFLAEFWDVIIMVVQQIPASHPLQDKLIALLKALSELPTETVVDIWEGESRVWQDLPLMGPNLVEAENYISQDQEPEKWRNFNAFCARLTRGDVCDMSLIGTHTLSKTLEDEPDPRARAYHAYREVFKKQVPVAALWIEISGEAMWKRCKGDISTEGLEDGCRGRLWKGKPLGLSMERWEFWKDRWAVIGEHPVADEETKEQARRMHEVMVRVEREAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV44</accession>
    <name>U4KV44_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV44"/>
    <dbReference type="STRING" id="1076935.U4KV44"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="16275" checksum="71EA7590AFFC88B1" modified="2013-12-11" version="1">MSDAGEEVPQVEVSEEIEVAADAPKGQMSVEDALKGVLRHALVHDGLARGLREASKALDRRQAHMCVLNENCDEEAYKKLVEALCAEHNIPLIKVADGKKLGEWAGLCVLDREGNARKVVNCSCCVVKDWGEESQERNVLLQYFETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV49</accession>
    <name>U4KV49_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV49"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4613" checksum="FCB16A196DEBA023" modified="2013-12-11" version="1">MMVLLDLHEFYNGSNTLVLLDLHEFYSGSHTPVIKSGMAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVC1</accession>
    <name>U4KVC1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">PCON_05045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935254">
        <property type="protein sequence ID" value="CCX05458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVC1"/>
    <dbReference type="STRING" id="1076935.U4KVC1"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX05458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="95" mass="10702" checksum="82CD68EBD80BD53E" modified="2013-12-11" version="1">MADNDNVNPISEPLDLVRLSLDEQVFVKLRGDRELRGRLHAYDSHCNLVLGEVEETIYIVSDDEEDDSVQIVKKSSEMLFVRGDSVVLISPQAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVP7</accession>
    <name>U4KVP7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="26"/>
        </location>
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            <end position="378"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="41847" checksum="EE7B921399C97B61" modified="2013-12-11" version="1">MRPLTIFPQLLLSILPLLCLLRPVTPSPLFAPLEDPLIFLDFDGTIATTDAFELLPETAYKTLSYSQSFPHWSYFSEAYLSDYSAAVASSPPKPRSIAEELSHQSSPSLRQVEIDSFTRVKESGILNTTSPRLLHSAAKGVSIRHGFYDFIQAAQSRNVPVSIISRNWSAKWIRTILRQNAPTGICGHVGCVFDAIDRMDIFCPEILPEGCVSCHERNHDTPIFSGEDKREVMKGFAQRGQVVFVGDENSDLAPILLEPTMMGVVAGKEAEAAKTIGRERELWDAGKGWRGYTRRGEGVYVMEDYKELMTLFGWGGIAVGQDKVDMGVEWTPLDPKEIYNGPGDVLDEVGQCDDAVVDMVGLEVAPYRKRAYPPVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVY0</accession>
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        <submittedName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="247" mass="28289" checksum="55CDA9A19E45ED88" modified="2013-12-11" version="1">MSIPPPFLPVCIPLGTRHVHRSWQLHDGRLHPLIEFPEETAELEALLSHFTLYCDVVLSHMIFPQNVEQVQMGYYVFVPECSFFEVAINRKGHRPLEMQQAALALLSLESMRFRLTQGEVMGILYVYSLAKGIRLPQSREERRVDLKEKRELLVSIAGEFWRLPYEYSWGATIEPYFRLIKKVLDLYEKWNEAFVQPMSPETKVQKKKTQKGQKGQKKSTAGMAANATANATTNATINATATDVEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWA6</accession>
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        <submittedName>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935269">
        <property type="protein sequence ID" value="CCX05732.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="95"/>
        </location>
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        <location>
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        <location>
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            <end position="685"/>
        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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            <end position="540"/>
        </location>
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        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="973" mass="106210" checksum="0B217FAD8201887A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWF1</accession>
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        <submittedName>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="4906" checksum="D6F6EDAD28466B25" modified="2013-12-11" version="1">MLVHSKFKQNLTLDTLHKTSKDHRALAPHAMICNLHNQKPGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWK4</accession>
    <name>U4KWK4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWK4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6167" checksum="A7DC93978779DCF5" modified="2013-12-11" version="1">MDDVKSPPSATQSSTDKNFFLLTPFRTFFPSRKSQVTTTTTSAHSLDIIVSVYPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX59</accession>
    <name>U4KX59_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LSM1</name>
        <name evidence="5" type="ORF">PCON_06174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX59"/>
    <dbReference type="STRING" id="1076935.U4KX59"/>
    <dbReference type="eggNOG" id="KOG1782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX06587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="14865" checksum="42F9131A9506F324" modified="2013-12-11" version="1">MDATDPPTLPPQMFTTSAQLLDLTDKKLMVALRDGRKLIGVLRAWDQRIYTDEMYADVPRGVFIVRGENVLLLGEIDLDKEDDVPLPQGTFNEAFTHQKREATETKRRERVQRRKLRALGFEDEGEVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXJ8</accession>
    <name>U4KXJ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935294">
        <property type="protein sequence ID" value="CCX06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXJ8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="66" mass="7435" checksum="E92D0DC37C640B4D" modified="2013-12-11" version="1">MMMIPTSTLRRSFGSVTRALIWGPSLWNILQVPSTYIGVHLTYITDQRDLKRSKLGPGSLLGLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXP7</accession>
    <name>U4KXP7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Protein BRE4 acc. no. Q07660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXP7"/>
    <dbReference type="STRING" id="1076935.U4KXP7"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWGWAAN"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="714"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="851"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX06601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1139" mass="127682" checksum="0B101D9F9B2743F8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXU7</accession>
    <name>U4KXU7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized transporter C1683.12 acc. no. Q9P6J0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXU7"/>
    <dbReference type="STRING" id="1076935.U4KXU7"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWGICMT"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX06997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="492" mass="55317" checksum="48140AEA462EE8BA" modified="2013-12-11" version="1">MGDHSSEDEKMEVQEIEDPDAGLSFEEREKIDRDLVRKLDFKLIPWLCLLYLVSFLDRTNIGNAKIEGLVDDLRMTQGQYNACLTIFFVSYSVFEPLSNMLLKLMRPRIYIPIIMVIWGACMIGMGFCKNYPQMMTARWFLGLAEAGLFPGVNYYLSCWYKRREFGIRAAIFFSAAAVSGSFGGLLAAAISKMNGIGGIRGWAWIFILEGLATVVIGLISFWMVHDFPDDAKFLSEQDRQRVLRRLRDDQQSSGGASEDFKMVYFWQSVKDWKTWTGALIYMGVDGALYAFSLFLPSILKELGYSTTRAQLLSVPPYAAACILTIVIGFWSDRTNKRGVFNICTSVIGILGFSILLGSKGHNPVLSYVATFLGALGIYPCISNTITWVSNNVEGVYKRGVTIGFVIGWGNLNGVMSSNVYRGRDAPHYTLGHSIVLGYLTVGLFGGSILNYFLLNRENNKRRNGERDHWVEGKTAKEIELLGDMRPDFLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY60</accession>
    <name>U4KY60_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935320">
        <property type="protein sequence ID" value="CCX06901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY60"/>
    <dbReference type="OrthoDB" id="5352771at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="196" mass="21496" checksum="BDDED5FC7DD0757F" modified="2013-12-11" version="1">MMAIEKPEDQENDAHLLDTSIDSGIWALGISDNHISTSLSSSSGDSTPNSASGESEAQSQFDFIHIRYRSGKITPRVWRVAFEQTKPGGWIEVVESENTNTPRPRIKSDLVRAGFVEVEDRIGGRVTGGTMWQRLAGLVRGVLSMGMGAADCGGNGDNRLVAPVVPIVVSIISLEINFWRIELTKLQCFRYCKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYN0</accession>
    <name>U4KYN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935310">
        <property type="protein sequence ID" value="CCX06760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYN0"/>
    <dbReference type="OrthoDB" id="5425163at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="242" mass="27240" checksum="74275F581BD3C58F" modified="2013-12-11" version="1">MDKTAGPSPQPTPTVTPARSPNLQPIDTVTTDENAARLESLIRSVDAGTLRRILVSALSGHVAQLHPPISESTTPTSTRPPTAKLHSSNGGTHPESPLVQALRTRYPAIDPALFVMIQKNRFRPDHIFKLSTSFRPQRPDYREGLSCLMQPLNLYTQILAHFAAADVKLELAAALADYMDHLFELNHTHTFESVKEFHLTFHQKRIVVGVWDPAGWREKDQQMEFLNLVKRKAPAELWWESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYZ0</accession>
    <name>U4KYZ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to D-alanyl-D-alanine carboxypeptidase acc. no. P15555</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYZ0"/>
    <dbReference type="STRING" id="1076935.U4KYZ0"/>
    <dbReference type="eggNOG" id="ENOG502QQBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WWMPYDE"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="21"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="3">
        <location>
            <begin position="418"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="552" mass="60595" checksum="A0A696E23BC174EF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ67</accession>
    <name>U4KZ67_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_06935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ67"/>
    <dbReference type="STRING" id="1076935.U4KZ67"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX07346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="254" mass="28508" checksum="8B1AD6637CA21DD6" modified="2013-12-11" version="1">MSGAGNREAVFATRQSLGIMKAKLKGAEVGHSLLKRKSEALTKRFREITRRIDEAKRKMGRVMQIAAFSLAEVAYATGGAGNMNYEITQAVRSARFRLRTRQENVSGVLLPAFESYTTEGLGDFAMTGLGRGGQQVQKAREVYEKAVETLVELASLQTAFVILDDVIKVVNRRVNAIEHVIIPRTANTISYINSELDELDREEFYRLKKVQGKKQEESAALELEEKNRKTAMPEVRDVTVPHNAEEDDEKDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ86</accession>
    <name>U4KZ86_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ86"/>
    <dbReference type="OrthoDB" id="5372118at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36316" checksum="8B086AA4C5BDE719" modified="2013-12-11" version="1">MASQPETVPANVTATIYPSIIEFLSIATEPLYQREWPNSIPLGIYPSYLSASTAPPRQYPLKPGESPETFILISSNEGLDHHICLVATKTPSYGALSVYSAVPPEFLDISAHITVLVDALFSERDVENIPRAYNGDSRLSLPMANSVAARLGLKVKIEERYTAAVLTAETISPDIPRQPLPVDHDIRRMLPGEQTGRLIEMYRGMFQETRGIIVSEEAAKGVVEKAVGRGEVWGYFVAGEVVSSALLGRATRTGKSVTNVFCRQEFRRRRLTQALMDEIGRRLVLDEGLGYLGIFFLEGGTASRIYRRTGFCGEEWGIMDFVLAVDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ87</accession>
    <name>U4KZ87_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935371">
        <property type="protein sequence ID" value="CCX07750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ87"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="136" mass="14882" checksum="A612FE2AFE6D1C1F" modified="2013-12-11" version="1">MAKESLKSCCSLFEKLGRRSGTRISYDTVTSCVNVCGNTFEDVVKGRKLLLDVIQIASYNVWPFRAIHTTSILGSAFGLEQAIEFVPYKGPLSYIKESNGSRCGLFVINPTDLDVDKVLAGGRGISNMSTSRMMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ98</accession>
    <name>U4KZ98_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ98"/>
    <dbReference type="STRING" id="1076935.U4KZ98"/>
    <dbReference type="eggNOG" id="ENOG502SX2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="477" mass="50782" checksum="105D54F30F24DD3B" modified="2013-12-11" version="1">MPAKAPVDENVRFLYSCLIRSDYHCIDFHRVANDFGINPAAARMRWSRLRKNIAVNSNFKNDPNIPGGYVAQTDKKKRKNDGSSGPAVKKGKMKSDGQDDDDDGLLPDNWIKREMKTEDVGFAGDFGIGAFPDAAVYGNYDMMSHGVPLGVAYDGQVGLAGSIEGAGIGTGQGLLNDMNNAEHTMQLDLLDPRLFATGIMPNESCSTGQGQISFPLAPMATSAADAAGYQNHTILPQHQTPPTYPVARVRNLIPAAPHPNSNGSETEVPSSTADPRTINSNSVPDYQLTLTAGREKAPSARKDAEVNNGIEVLSSSANEVAGTGNETCRMDKEGASTAPTADMFAGPGSSDKASESKVAYDDILNNAKEVSSETVLVKSVVKPHSTSGTVHLPFRNGTGKDDTKCNDAESIAADISGRLLRSARKLKKSQSGERVKTVQGQDGSVEGGSADSEAMTGDEQEEEEYDAEDSDGSWMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZI8</accession>
    <name>U4KZI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to GDSL esterase/lipase At5g45920 acc. no. Q6NMR9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX05109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="11"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="263" mass="29724" checksum="CDC873173AC44BE6" modified="2013-12-11" version="1">MAFADYNKILLFGDSITEQSFEQARGFGFGAEFTNVYRRKLDVVARGFSGYNTSHALHILPKVIPPPTETIFFGANDAVLSPQLQHIPLSSYTSNLRALCTHPLILSHSPSLILITPPPICEYITQESDAAKGKNYIQRLAAQTKQYRDAAIAVGKELNVPVVDLWGAFVEYAEPGYQWREGGDKEIPGCKERERNPKMGELLRDGLHFNPKGYKIMYDEVIKCIKTHYPELDPEQLEFDQKFPYWEVAPKHDEEETTGQSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZT6</accession>
    <name>U4KZT6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX07275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="6808" checksum="0DC8DFBC062B8E96" modified="2013-12-11" version="1">MATDIRAACPEITLQSPGGPKSPPQVFRAPAERLLNMFSCAGCAAGNLYPSDPFDRRSGVWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L094</accession>
    <name>U4L094_PYROM</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_07558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935384">
        <property type="protein sequence ID" value="CCX07969.1"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RG5A">
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    </dbReference>
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    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="599" mass="66860" checksum="0294C4F0AE72E971" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0C9</accession>
    <name>U4L0C9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0C9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11433" checksum="2D757008C9EDA304" modified="2013-12-11" version="1">MRSSLRKIGRQCNNSNKITLTVEFLLCGLHINLSLEMMSMWQKMLNPLGSTSLGCFVDTWTLLFMNLERARVENFQKRNGIPYTTKMPLCTVSMANAFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0N5</accession>
    <name>U4L0N5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF935375">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0N5"/>
    <dbReference type="STRING" id="1076935.U4L0N5"/>
    <dbReference type="ESTHER" id="pyrom-u4l0n5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EWSKGGF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005147608" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="528" mass="57811" checksum="81EB3A583CBA410E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4L119</accession>
    <name>U4L119_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L119"/>
    <dbReference type="STRING" id="1076935.U4L119"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="609" mass="66873" checksum="903060A27BEECC61" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1G3</accession>
    <name>U4L1G3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1G3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="10133" checksum="6B9D95D27346708D" modified="2013-12-11" version="1">MVTLREAEFGGRNPDLRGIGVLWPLTVLVCTTTFGCWVVILIYHIEQHEWYRKLKAKKPDNWRVALVLAFKDAFTTALTSILDLVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1V4</accession>
    <name>U4L1V4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_09223</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1V4"/>
    <dbReference type="STRING" id="1076935.U4L1V4"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
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            <end position="462"/>
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            <end position="20"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00021796"/>
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    </evidence>
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        </source>
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        </source>
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        </source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047995"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX09631.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="635" mass="71332" checksum="9A8D8FC83807942A" modified="2013-12-11" version="1"> </sequence>
</entry>
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    <accession>U4L2F1</accession>
    <name>U4L2F1_PYROM</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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                <person name="Nowrousian M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <end position="43"/>
        </location>
    </feature>
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            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX09330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="8675" checksum="3068A41E1796C47B" modified="2013-12-11" version="1">MLAIHNAANISAERPPQPLYQSYRPTAAAPPAPPPRYPNQYFSTQNCTAAGTRSSYVGHGLRMGMRKSKNGEGQMSVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2P9</accession>
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        <submittedName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
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            <begin position="164"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="519"/>
            <end position="769"/>
        </location>
    </feature>
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        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
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        <location>
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            <end position="784"/>
        </location>
    </feature>
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            <begin position="827"/>
            <end position="843"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX06518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="901" mass="99547" checksum="C6C6258B95EDBBEE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2S9</accession>
    <name>U4L2S9_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="163" mass="17953" checksum="0C93CA50EA1A1272" modified="2013-12-11" version="1">MRPSIVVQPTKRPGVAISIHLSLCSPSDLFLTPTYTPETSNITKIINMPTTKRANAECTTLGCTKTTPINILASEVEARPQLCTTCKIAGHESKAKEPQKATQATSNIRLNSAYTKRRDVACRENPDHDLKAGIQKALEDSQNQQPKQVYVIQSLPSSHSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3E8</accession>
    <name>U4L3E8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Putative ATP-dependent helicase HRQ1 acc. no. Q05549</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3E8"/>
    <dbReference type="STRING" id="1076935.U4L3E8"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GAVHLHQ"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="331"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="547"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124260" checksum="E6CC960ECB9F5EE7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4A8</accession>
    <name>U4L4A8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Peritrophin-1 acc. no. O76217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935333">
        <property type="protein sequence ID" value="CCX07133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4A8"/>
    <dbReference type="STRING" id="1076935.U4L4A8"/>
    <dbReference type="OrthoDB" id="2304619at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651890" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="9971" checksum="3A90D40DBF81F9E9" modified="2013-12-11" version="1">MQFSTIVSVLALTATALGAAVEKRSPVGTCPQWRDDAHWLLEDANDCTVFYKCDRSGPVKIACPQGLHFDIRQNWCDYPERAQCNKAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4H6</accession>
    <name>U4L4H6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Nuclear cap-binding protein subunit 1 acc. no. O14253</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935341">
        <property type="protein sequence ID" value="CCX07208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4H6"/>
    <dbReference type="STRING" id="1076935.U4L4H6"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CAAEGLM"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="327"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="539"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="801" mass="90573" checksum="512A52958471996A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4T1</accession>
    <name>U4L4T1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_11666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12072.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4T1"/>
    <dbReference type="STRING" id="1076935.U4L4T1"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHFFATC"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX12072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="18655" checksum="CB727F730EC048AF" modified="2014-03-19" version="2">MAIEYLLLVSRQGKVRLAKWFNAYTHTQKEKLIRDVTSLVLSSKKGSCSFIDYKDSTITHRRYASLHIIVSSSPSDNPLLTLEILHRYIESLDQYFGDVCELDIIFGIEAAYAILDELLMAGELQETEKERVVKTVKRMDRKVRDENDAELERHLRESGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L536</accession>
    <name>U4L536_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L536"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="7033" checksum="2C19B3B2004D9833" modified="2013-12-11" version="1">MHAFAALKTNFMPPPRVNHKIRGLHLSGVKEKKRYTVYYWPHRIIDTRMVEINASAAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5T7</accession>
    <name>U4L5T7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5T7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8069" checksum="68251AEF863EA36F" modified="2013-12-11" version="1">MKDGRMVHRGSPKAAVEDKQTIQFPKPGQVMSSSQAPGDRKKYKELITIAEDNCKLVLGFTESVGGCTCNKTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6H3</accession>
    <name>U4L6H3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to GTP-binding protein 1 acc. no. O00178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6H3"/>
    <dbReference type="STRING" id="1076935.U4L6H3"/>
    <dbReference type="eggNOG" id="KOG0463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRFIQRP"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12075.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="652" mass="71383" checksum="93112D401BFB318A" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
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            <begin position="1"/>
            <end position="24"/>
        </location>
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            <begin position="8"/>
            <end position="18"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24684" checksum="0B25FEDD41836918" modified="2013-12-11" version="1">MLEVDPTVLEKPDEKDYESAGYDTSTASLSSSIHQYIFEEGRRYHAYYGHDKYLMPNDEKEQDRLDLHHEIIRLAWDNKLHEAPITNSPNRILDIATGTGDMGCRHGGSVSDGRRSRFEVDDAMKDWTFTGEVLEKAGFKNVTTLKVKEPMGPWAKDPKLRKFGAMTLLHSDGVFESYGMAAFTRLLEMDVEKAHGICQAAHRAARNKNYGKSLKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX14770.1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="15215" checksum="A74BC053D1ED5597" modified="2013-12-11" version="1">MRRSGSGAPDNLRGTRPPVLGVLDPIVSGQKSDGDGAATAWVLRPFSIMKFLTNGKKRFALYRLRISAPSQLPLPRCLVRRRLFETTPQPLIQRLDLSCFDPGIKNYYDHHQEKANIREPAIGFRSRNRSVGYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9N8</accession>
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    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX06904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13657" checksum="12DCAD233741CA2D" modified="2013-12-11" version="1">MSDDETKRNDAALDGIVSFALNPPSTHLRAKDRYNVLNKHLHVLFDDNRAQRILAMWKKDDAEDTTTLSKNVLRWFIRIRNGAPISTTFETTTSFFGFYYFPHAHPMRFHSPFGAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA04</accession>
    <name>U4LA04_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_01977</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LA04"/>
    <dbReference type="eggNOG" id="KOG0723">
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    </dbReference>
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    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX15596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="126" mass="13765" checksum="6A2C88B677895751" modified="2013-12-11" version="1">MSNSAYSEPATQETKESGIDMSTAILIGVGVAGAAIAGRVGLQAFKRYKAGGGATLGKQFYKGGFEHRMNRREAALILQMSERNLTKPNIRKRHRELMLLNHPDRGGSPYLAGKVNEAKEFLEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBT0</accession>
    <name>U4LBT0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_02856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBT0"/>
    <dbReference type="STRING" id="1076935.U4LBT0"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000016">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX16260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="289" mass="31212" checksum="8BEEDDABAB67595B" modified="2013-12-11" version="1">MVRQDPIQQISNAADRIKMVHEMLTPMNQKAPTRTFFIGGNFKSNLNKDSLKELVPVIAKHQTAADVVIAPPALYLLEAQSIVEANNSKVKVAAQNISGKSLGAYTGEIAAEHVLDAGIEWTLLGHSERRSIYCESDEVVAAKTVDALQKGLSVILCCGETEHQRFVENRTKEVVTGQLGAVHKALEAANLVDKWSKIVIAYEPVWAIGTGKTASTQQAQDTHLEIRNWLTTISQSVADATRILYGGSVSAANSDELAKQADIDGFLVGGASLSAQKFLPIIDSAKYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBV3</accession>
    <name>U4LBV3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Putative nicotinamide N-methyltransferase acc. no. Q4I2X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBV3"/>
    <dbReference type="STRING" id="1076935.U4LBV3"/>
    <dbReference type="eggNOG" id="ENOG502RXJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFARCYF"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="301" mass="33817" checksum="905F74709AF7814C" modified="2013-12-11" version="1">MTTSSPTREEILISLSTNGYVILPSLIPPALLSPLREAAARTIAKARLDWPHVRVVGKQFPPWPTGARDDVWGVQHIMHPDLQEPVFAEWYGCDELVEAVTTILQCEEKDIQLELCNLLINPHKTPFSLAWHRDAIPPATSDAEEIELLKAPRGGTQWNTALLDDECLLVVPGSHRRARTAEERRITIDDPRAPIPGELVVKLKAGDTVFYDNNILHRAVYPTNPERVTLHACMGTVGAGWERARNILQHGMEWVKEVKYDGRLEEMRGRLVRMEDEVVGKEVGYSLPEETAETIVTMVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBZ4</accession>
    <name>U4LBZ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
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        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7690" checksum="717B5CDD3B6B752D" modified="2013-12-11" version="1">MSPSPLLPIQQPSQLTINRYKLDEDKDDKPIWELWVMLVGVSACVGLGLWNLAQFVLEMKNYRSAGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC98</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="437" mass="48736" checksum="803DDC99B672C97F" modified="2013-12-11" version="1">MSQPRIVAWRSSSELLQLKSDFFPSSDSADTRPAAISKVTTWQTRVRIPHSIESTSQITSAVLLDHPHSHPLTVRLAYSTAIIRFVNGLLDPAQQSQFALPMHLLARNLNLPASFVELRHAATHESLPSLAVLRAMAHRALDWLWNDYWAALGTEEEVEEEPAMVERARTAVKTWRRLRREAPMAVVKADHEVVKVVKECVDISRADAEALVAALLEEKVLIPAGKKKAAKMKGARMLWMPLLLEIEAAVPGFIAGLVGAMEEVLKGGEELAAALLRETRGGELEGDEDYLAAVYAWMEFLTAKQQTVSGRIGVGINVEELAKQALITPNEWNIQLLKHILVEYPALKPKYQALVDLAAMHVQTQGGKKGKKANDEKRSLEDIDAEIDAFEAQLDRIQQKRTKPTTTLLVKEDKKAQVAGKWRRWEGEWTPKPFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCR3</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_07681</name>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10678536at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="178" mass="18978" checksum="478036201C305249" modified="2013-12-11" version="1">MLCTEPAYSVTVNVPVAKCKPRPSGSTKHLHQPRQRVTSVRLYRPTPAVADPPAPAPLPVPEIVFQDPAQIATDVVERPAAAAKPRGNRVQQALTAGTNRSGRVQKHINYNETVLSDQALKVAKKVQLANLLTQVPAPQPEPAPTPEPEPKPAPVKPAAKGKGAKAQPVPKKKPAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCS3</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_07691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S1M0">
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    </dbReference>
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    <dbReference type="OrthoDB" id="3596604at2759"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="634" mass="70122" checksum="6AE4F55CEADCD9F9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDS9</accession>
    <name>U4LDS9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935725">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="4753" checksum="3C89C2FF55FD37E2" modified="2013-12-11" version="1">MLCKFQRLRVSYLHFLIGNSTLIAIGAVSSVKEPGRKGVLDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDU4</accession>
    <name>U4LDU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Amyloid beta A4 protein-binding family B member 1-interacting protein acc. no. Q7Z5R6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDU4"/>
    <dbReference type="STRING" id="1076935.U4LDU4"/>
    <dbReference type="eggNOG" id="ENOG502S2MX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTWRSWY"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
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</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="138" mass="15989" checksum="9A10594810F164FB" modified="2013-12-11" version="1">MHLPGGQVGHLLSHQQTCQGIIQLQLINYHCHISLRKIQHFETRPKNNIQIIESLDKMSNGNMNHLKPTLSNLNIIKTLTKLTKLTRLANFTLHQILKATNRNLNTRKQIANITRTPRRETTLPYHHPANFQPTEPRQ</sequence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="735" mass="79357" checksum="912447BFD2857CBC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kumar A."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="238" mass="26096" checksum="ABED9CC7B5E96ED3" modified="2013-12-11" version="1">MESPTAQQHPQTPIMTDVDEQSMAPAPSPPTHGWFVELRGHITLSSITDWFYMTHHFRQGILHTSETSWLIDYPDKERCEKAMEYAKSCRCYGGWLRPSSRTGIPRITSRILHLELSSITTIHEPLEPSFLQRPTPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPPLTPAPSVTIPPPVHVEVPFRRGVPLMGMRLEWFVQEMLVTEESVMRDIERRSTGKYQLHIAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEC1</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX29877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="50" mass="5700" checksum="4E5F02BE07628FE7" modified="2013-12-11" version="1">MFSLESNPALYSRSTIMQHYDSRHSTAGPSRIPMIHTTLMRGIYAKNARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEW7</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7421" checksum="B0563BBC0B6AC5E4" modified="2013-12-11" version="1">MIWSGTSRWGNRMTLSALPKLSNSDYSVFQSSLISAPIGSPQPLGFLELSEITLCMRAALYRLSGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFR1</accession>
    <name>U4LFR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="OMA" id="MESSVWP"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="278" mass="29271" checksum="65BDF229C43E29A5" modified="2013-12-11" version="1">MSSTSATPADPQAAISPTSAPTSTPAQELQQSTPIPIAPRPLRPDSSSASISSPNLVSSRPHSPSSPHGSVTTRSHPHIRRPSSSMSSSSWRAYLTPDPSLPQRLPPSPPTNAAGVFQELEAEQEFHVNRLLHMIRIQSMQAGTSTDGESNAATVDSASTRGGRPRSPMSHKSSNRLSRDGSFYRQASISRASSPGFASTAADSASEVSAWNGSRDANFYIAENTMVKRENEMLRMRIRELEKAVAELSKGGVATTAPATSATPATVPEEAVAPSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGY5</accession>
    <name>U4LGY5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGY5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13281" checksum="6A92E4BDF0046943" modified="2013-12-11" version="1">MVNDSILEMLFNVKPRTLTMFYNSSLKTTGVLSSENERNTKSQRKVFSVDIRDEPRQFPENREKSNDHELIAWTNRPRISAIDYPTRRSGPGIEQKQPNSCFTVGLCNNGGAGSGAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI29</accession>
    <name>U4LI29_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935659">
        <property type="protein sequence ID" value="CCX11974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI29"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6303" checksum="6F56FE910EFB6E68" modified="2013-12-11" version="1">MGSSGGSDRSSNSLDAHHSELGIKKTDASCSPRRLCHLGVTRQRLRGSIGIDMPTRTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIK0</accession>
    <name>U4LIK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Magnesium transporter NIPA4 acc. no. Q0D2K0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIK0"/>
    <dbReference type="STRING" id="1076935.U4LIK0"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="733" mass="79200" checksum="8E5836198581E3EF" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIV2</accession>
    <name>U4LIV2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Fatty-acid amide hydrolase 1 acc. no. Q9TUI8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIV2"/>
    <dbReference type="STRING" id="1076935.U4LIV2"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GMQPWKY"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="113"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="542" mass="59057" checksum="19B89CDAB3FD08DE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ46</accession>
    <name>U4LJ46_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_03883</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936562">
        <property type="protein sequence ID" value="CCX16994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ46"/>
    <dbReference type="STRING" id="1076935.U4LJ46"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQQCSAK"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="457"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="490"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="597"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="660" mass="72394" checksum="350CB6C71DC1187A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJC2</accession>
    <name>U4LJC2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="325" mass="35092" checksum="E9DBE79AC2A11D0D" modified="2013-12-11" version="1">MSDLAPPSYPHETVPTYASTGGSDAFLESGGPALGDKKISPAESDANDPSSTTGPKFYFQRETIRPFRSSLILPFSPNPQDCRPIYLQKHHPQHISFLPGTNHPDITLYRGGDDEGQVVATAAVKSSLLGKTVGEVKMFNTGVELLQLRKEGSKAVFEFGGRKLCWSIVVTQKPPMNAAEHRGSVGGEEETGEVKGFKGKMKEVMDKKPETLFLCYSAKLEEVVSGEARASQGSQGTAEAKPLAEYEDIMPNNRPMTRDLIYKNGHVGVLEFKQGATAEFVDAATAMLVLVIERAKRGISTRKSGPGYAFSPFTGMALSGGMWGV</sequence>
</entry>
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        <submittedName>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039553">
        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12927">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="586"/>
            <end position="659"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="405"/>
        </location>
    </feature>
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        <location>
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            <end position="519"/>
        </location>
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        <location>
            <begin position="571"/>
            <end position="610"/>
        </location>
    </feature>
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            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
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            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
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            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="242"/>
            <end position="252"/>
        </location>
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            <begin position="317"/>
            <end position="338"/>
        </location>
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            <begin position="347"/>
            <end position="364"/>
        </location>
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        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
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            <end position="519"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12573.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="665" mass="73159" checksum="2C7F9DEE84A8A9FB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJQ1</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935725">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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    <feature type="chain" id="PRO_5004651422" evidence="2">
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            <begin position="18"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="320" mass="36220" checksum="66C21D480A23AFCE" modified="2013-12-11" version="1">MIIGILTLLYLLHGVESASTDGIWLPPLKNLTALNEEHAPTWVAQPPYRETWGIIYNFTITLGLCVYTAIHINIPAPTDSPMKIWFRKLKWMLIALIAPEIVLYTAWAQFYSARSLCKELNEHVHAHNEKVKEIFGKPFNTSTAVLELAPTDEQPVNTTPNMRPEIEIEKHVNEHNEEHETTSAKRPITFSSAVQSPIEEGIIKRGKGEQPAILTSEVQQETEKKLELDDYDLMMGCDIAMGGFVTGQPDTPAQGDNDRNSYQTLDPYDVTYLVNKGEFLRVEQKQIEDKSKADILAKFLLEVVADDVNRPRLESSRVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJR0</accession>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="14357" checksum="753B91C23C92046D" modified="2013-12-11" version="1">MHELRAKPFDRMLVGTQYSAEGADSDAISKTKDKVYEILGYLDIECYPSEADANFKVANVNDLVYATISPILIDFKRRVGRNSIQLLREKEIISTDGEPGGVEEFIVVDFISVMEENIVLIIEAKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK01</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6344" checksum="DFC2BF26D6AA6401" modified="2013-12-11" version="1">MGPSPIRALRASPSLSSLRQSSIPYGGMGMLLIDGDVVHAAADLRTANARVYRVCWMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLN2</accession>
    <name>U4LLN2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935997">
        <property type="protein sequence ID" value="CCX33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLN2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="78" mass="9009" checksum="BF6E69B3202EF026" modified="2013-12-11" version="1">MSRTGRAVLQLMPFSPLDVLREPLQQTSAALINFRSPLASFYERVGSFVFYCFATKTDALRDRDLLYFSKLERLSELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLN9</accession>
    <name>U4LLN9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Pc20g02940 [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002562847</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935431">
        <property type="protein sequence ID" value="CCX30265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLN9"/>
    <dbReference type="STRING" id="1076935.U4LLN9"/>
    <dbReference type="eggNOG" id="ENOG502QYKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5332870at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="659"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1095" mass="123044" checksum="9DFF5874B30623FC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM05</accession>
    <name>U4LM05_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Sugar transporter STL1 acc. no. P39932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM05"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVFVYYM"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="22"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="540" mass="59141" checksum="CAB16818AF48C64F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LML7</accession>
    <name>U4LML7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Calcium-binding mitochondrial carrier protein Aralar1 acc. no. Q9VA73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LML7"/>
    <dbReference type="STRING" id="1076935.U4LML7"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="91"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX15398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="223" mass="24410" checksum="81E8705F437ED140" modified="2013-12-11" version="1">MVATAPVPNPGNHRYNYYSGGGYDSNVDTVVKSAIAKSKDGKITRAEFLNKAARIPRFSHFTPLEADILFHFAGLNQETDCLSWEDFNRDLESAYKFGLGAIAGAFGATMVYPIDLIKTRMQNQRLVGEKLYKNSIDCFRKVIKNEGFKGLYSGLGPQLIGVAPEKAIKLTVNDFVRTKLTDKNDKIASPLEMLAGRTAGACQAVFSVHQVSFLNLATSGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMM0</accession>
    <name>U4LMM0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMM0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652183" evidence="1">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="113" mass="12465" checksum="A47AFC0AC0E99167" modified="2013-12-11" version="1">MRPLPTTILLAYLLACVLALPTADYKIPSSEIALPVHRTSNHELEAPTKLDIKANSTESISPRNAKLVLLICKAPDYADCGQYRPTPNECKNLKDQDGDMNNAVDFGKELRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMQ8</accession>
    <name>U4LMQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ankyrin repeat-containing protein, putative [Penicillium marneffei ATCC 18224] acc. no. XP_002144344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMQ8"/>
    <dbReference type="STRING" id="1076935.U4LMQ8"/>
    <dbReference type="eggNOG" id="ENOG502SAX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWAECQI"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="230"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="618" mass="69758" checksum="77782954748A9502" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN81</accession>
    <name>U4LN81_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_02334</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cytoplasmic vesicle</location>
            <location evidence="1 16">COPII-coated vesicle membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
            <orientation evidence="2 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936264">
        <property type="protein sequence ID" value="CCX15875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN81"/>
    <dbReference type="STRING" id="1076935.U4LN81"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="126"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="404"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="522"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="634"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX15875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="770" mass="86447" checksum="46F6DC4BD7FACA02" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN87</accession>
    <name>U4LN87_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Protoporphyrin uptake protein 1 acc. no. P40100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN87"/>
    <dbReference type="STRING" id="1076935.U4LN87"/>
    <dbReference type="eggNOG" id="ENOG502RZA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WECLGLI"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="289" mass="32870" checksum="D0612FFCB57DF6B0" modified="2013-12-11" version="1">MADNQSNHDSVWEYNPSKAAAILFTILYGLTTFGHFFQMFQHRKWYCWVLVMGCSWEFLGFLLRNLSITNPTSVPLYAPMQTFIILAPLWIAAFLYMSLGRLIHAFLPSRRCLGLSARRITLMFVLGDIFSFIVQLSGSMFLTGSNPTPEKFHLGTSILIGGQCLQLLLFSFFIVLGIRFEVNYKQEFGSTSTSGRERWIKMMRVMNFSCACIVVRSIFRIAEFASEYPGPLVSHEVAFYVLDAVMMLFAVVGFHLVHPGMVLGEEGSFRAEKKRAQNSRSEVEMGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNJ3</accession>
    <name>U4LNJ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNJ3"/>
    <dbReference type="OrthoDB" id="10462178at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="315" mass="35928" checksum="1694038EA66C18AC" modified="2013-12-11" version="1">MCYIIKHSRTSYPSNTLFLLCQITPLSSSPSRRPSLAKRIHIYVAGADRVSHDNSQQTNHYIFRLPPSVYIFDFIELFFFYFCNEKMRTRYPNILNACDTDPKTGAIIPRSPIAPQSQATPEAAPIHAHAPAIGPVRALSFTPVITPASIEGPSPIHKPRIPVWRACEPCRKSRACAHKNAMLLPLKSDGPDATLTVIQDCLLSQPPFGRVKQPPKKRVRVRRKPEHLQQKRGPKPGWKVKKREEEERRRLAGGEEEKEEEEDYDEDYDEDYDEDDEMDIDQDYTAARRRPSPRNQKQRYRAGATTGSTDAASVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNS3</accession>
    <name>U4LNS3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="4">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_01469</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="4"/>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LNS3"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFGIWVA"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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</entry>
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        <source>
            <dbReference type="EMBL" id="CCX33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="12455" checksum="B46F2EB9CBCD2A6A" modified="2013-12-11" version="1">MGELLDLSLEILTVCQCKRGIERLGRTFKIFNRPEVEMLEKLTKKLAVFAWPVLEYTKRGMVKGQSNRWSLILESYDKKKARKSGTEICGDPEKKMAWSIVVSAKDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPN8</accession>
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    </protein>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="CCX33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="314" mass="36312" checksum="B16148903327D489" modified="2013-12-11" version="1">MESRPLFRGVPARHKQPRGIIDDFKGVSQPKKPNVWSKFYRRGPNIEMTPPGPSPSSSNVTIFDSEVKALKFYFQQIEDLLRAFRLIAYVVEDPRCYKDMDNWHQWMKENVMSHWRALWLDTEWAVNELVPEEKVSRQTRTGIIVEAEHSAKKEELEAVGKASSAVDTPVGYNYYRVSWLSLTKFIGIVFSDIQDMLRVLRLSQSQQDKAVVAWHSDLMNKYCDMRNKMREYMRKQLRTFYNLGGTIGDCSDHLTPIEIFKGKINNASKDLENHNASDELSFLLKEDARRIREELQKLNSATAPAPLVAPEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPX9</accession>
    <name>U4LPX9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652262" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="110" mass="11949" checksum="17292E7A81959B61" modified="2013-12-11" version="1">MQLSSIVTLLSTASLCLAISTGSAADPLQIWKPVDLTLEDTTPSSLANSISALLCRKWDFKMCSHTFNDPDVCYGLVGSEIDTKYVPPWKLGCSWAFADEDDIKDPIGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">DUF1446-domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">PCON_01632</name>
    </gene>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="498"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68311" checksum="7D55ACBD1E72F924" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQH2</accession>
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        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936392">
        <property type="protein sequence ID" value="CCX34200.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="21442" checksum="918A2AA641F05AE7" modified="2013-12-11" version="1">MAPGAPRGKRKPTRGGPKSFSRNLSRLDADEGIPDSIVDNNAADSSEEESSEEEAQELTREERRAAAKAKKEAAKAKAAALAGGASGSEDEDEEEDAPKPAAAAAAPKKMIKTSNPNDPANAASGGPSRREREAMEAAAAKERYWKLHQQGKTDQAKADLERLAKIRAEREEKAKQRLAEAEERKKEAEAKADAKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQM4</accession>
    <name>U4LQM4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
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        <name evidence="16" type="ORF">PCON_02091</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQM4"/>
    <dbReference type="STRING" id="1076935.U4LQM4"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000666">
        <property type="entry name" value="DNA repair and transcription protein (Xab2)"/>
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    </dbReference>
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        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000182">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
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    </dbReference>
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        <property type="entry name" value="HAT"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
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    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="213"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="423"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="846" mass="98794" checksum="17C659BD2347CC02" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQY2</accession>
    <name>U4LQY2_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQY2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="3841" checksum="087152376B5FFE68" modified="2013-12-11" version="1">MNFNGTKGFCLTAPRFCFRAQSTRRSVDSAMLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT97</accession>
    <name>U4LT97_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT97"/>
    <dbReference type="OrthoDB" id="3945378at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="7665" checksum="52DE297B7FF46A79" modified="2013-12-11" version="1">MSEGVVAGGSDIFGFGVRIGFYLTGLSLILSKIFCPSRLSGIATSIGLLELSTKTTLAVSMLRGSGALFFSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU52</accession>
    <name>U4LU52_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Complex I intermediate-associated protein 84, mitochondrial acc. no. O42637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU52"/>
    <dbReference type="STRING" id="1076935.U4LU52"/>
    <dbReference type="eggNOG" id="ENOG502S2J3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENIPEVW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="893" mass="103247" checksum="4F7F3011BB88CB50" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU53</accession>
    <name>U4LU53_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Nitrogen assimilation transcription factor nit-4 acc. no. P28349</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU53"/>
    <dbReference type="STRING" id="1076935.U4LU53"/>
    <dbReference type="eggNOG" id="ENOG502QSDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LNAECIY"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000008">
        <property type="entry name" value="C6 zinc finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="684" mass="75663" checksum="6F0AF5F6D8426E52" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUR9</accession>
    <name>U4LUR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to RNA polymerase I-specific transcription initiation factor rrn3 acc. no. Q10110</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUR9"/>
    <dbReference type="STRING" id="1076935.U4LUR9"/>
    <dbReference type="eggNOG" id="KOG2434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCSPAIV"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="699" mass="80325" checksum="4CE4ED3464575076" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV15</accession>
    <name>U4LV15_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV15"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="144" mass="16965" checksum="FCD3041E006D8A63" modified="2013-12-11" version="1">MDRVKKLIQRRLELAGFSANVADILPKIFHSINDQYDFIKNHYKYGRPIQEMQSILRIKPYLTQAKTSERDGDKARIYIRAKEVDVDLAEEVIQVFARMYTDERSTRWSTECLNAIRKTREEGTKLHLSIHGARKGFYVWDTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVZ9</accession>
    <name>U4LVZ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVZ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="7967" checksum="94E1F296E0FBF461" modified="2013-12-11" version="1">MSSRKSRDKIKFYYQKGVPIRAIGQHLMKHHQSLVSASRERDNASCILGEPCLRHGVECALCYVHSRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWD1</accession>
    <name>U4LWD1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_01457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="HF936139">
        <property type="protein sequence ID" value="CCX33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWD1"/>
    <dbReference type="STRING" id="1076935.U4LWD1"/>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARRCPIM"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="211"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="647" mass="69906" checksum="DF259EEC96B1A852" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWR6</accession>
    <name>U4LWR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWR6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="127" mass="13846" checksum="27F4EC6A89DAD778" modified="2013-12-11" version="1">MVSVNVVAAQSSLCIAGDLPCGSDQHQYVVSPSFLFKLFLTPRKSRTSSWETIRLVNIPGDIPSGNMCTPIILHKGGIALSWSHKKIALNPTGNRSIEVCGFEIPRVTYLLYGSLVHGDFCQILFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWS2</accession>
    <name>U4LWS2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Uncharacterized protein YNL108C acc. no. P53929</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936296">
        <property type="protein sequence ID" value="CCX34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWS2"/>
    <dbReference type="STRING" id="1076935.U4LWS2"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICAHAAP"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="292" mass="32184" checksum="5AEE17292FC952A7" modified="2013-12-11" version="1">MLEIIYVARHGFRSNWTTDNNGNYSTSIVSPTGIASDPPLAAYGVTQAHELAEHASKLSPGIDRIYSSPFYRCLETINPLAEKLDLPILCDNGIGEWYGVARFDHPQPAAPEILHKFFPRVETGYNPTIIPSTKGETLQEIHDRTAYAVAKIINDIDREWKDQERGPKAILLIAHAATNIALGRALTGDKDADIRTGTCSLSTYKRRDKPAAPINLPLPSTEHPIPDTNWMNGNGVMGGWEQLTNGDCEFLAGKEERNWWFTGDESWDFPLKTDTKAVDVGGPGTVLEAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYD4</accession>
    <name>U4LYD4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYD4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="81" mass="9699" checksum="96D049170ED0ACE2" modified="2013-12-11" version="1">MLYSMHKQPQSWRSPDFLIDGHIRQTADVSCIGRKYLYDSPLGLRWVSVPLHLVFLFLVYVCRRSNHFQEKDGRPKITFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTY9</accession>
    <name>U4KTY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935209">
        <property type="protein sequence ID" value="CCX04583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTY9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="154" mass="16983" checksum="318E1B8416A7E742" modified="2013-12-11" version="1">MTSQTTSFVLTPSHIPTLATKIHDFCLYTLPYGVPGYLFLDFASFTSIKLPWLDTKRRLLGINHEGFHIELLSVLRDFVESMSGDLSGGEEKEQEGIVGCIVRNRDWYGRCLVKEFGNLFSTDDLGVGLIDADNWVISGALAEGSLALPPTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU28</accession>
    <name>U4KU28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935214">
        <property type="protein sequence ID" value="CCX04693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU28"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="145" mass="16249" checksum="5EB6ACCB8B485C33" modified="2013-12-11" version="1">MRNKDVISGLPLAPLVARPWFAERPGVRCMMSEQAKRDARLDISFSTFATSSRYIRNLIGGEGRDRSAVHIGGTRFDISIPRVTLLLRTVPYRQLNHIVTVCEVESTGTKAPRVDKSSAMQPIITTRQLSIFTFPLTPQVFLDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUY0</accession>
    <name>U4KUY0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935220">
        <property type="protein sequence ID" value="CCX04917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUY0"/>
    <dbReference type="STRING" id="1076935.U4KUY0"/>
    <dbReference type="eggNOG" id="ENOG502S8AN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="286" mass="32697" checksum="057FBFA1552FAEA5" modified="2013-12-11" version="1">MSRSKTPIRFIGCSKLSCFLCNMFLHYFGKFRARGTHRKLYTSLEQSLVKLTKRQYIQRKPLQPDSVSGISATVLDDTLPEDVTTFISNEEISRMTHGLLNKSKTSQRQMDKRLASQWHTVCPEDSGDEDSCDQDSATANQHCHPAFASRRICAGNSCELDEAEAQYPCPHCGNVWYCSEKCMRNNWSHKFSCTVPLKSADYLIKACLNDMFPEENALRDCGFESASAEERSKFLGLYQGCTMQGIDAEVLHEWWSKDILAETPSGKPWGLLQMVLEQQRYRFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW14</accession>
    <name>U4KW14_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW14"/>
    <dbReference type="OrthoDB" id="10404304at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="389" mass="43822" checksum="5DDD441E60105F37" modified="2013-12-11" version="1">MCQWRCNFFTKCGHQPAYVETLCSHQKSERDTWTRGIIMQACGTFNIPEVQNLDDICPDCTDLKYSGSASYEDPSDEHVSHKPSLSELEAAITARHMKEKREARESSHTSAPSEKSMFYRPGSYFERPTQSNRQPTFSTQGEGSSSRQYRPSESSKLSMQQVPQVGRGGIPKQTPNKPSQGSGSSFIDQHLRAQREPKLQSFSASHSTSTYDRTSIPMPYVQLSHLSTQHNSQRPSFSSFSESSERTRTPTTPEGRQQQRTTTRDRTPESWEKSASAYFQARQRTATRESILRDPAYWARASEITNREQMSKGLSPSELGMRSITPAEWRAIQMQFIAQSLPEKQGIWQQPHSRAITTPSNDLDSRAMAAAIDGASPKKTGKGRMYPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW65</accession>
    <name>U4KW65_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW65"/>
    <dbReference type="OrthoDB" id="10486608at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="25623" checksum="D3A05103F5E865CA" modified="2013-12-11" version="1">MAPRTISSASALALYQPPRLPTAPPLSVRSGIQKRRRLRNRTQPQKLSRGKGYTWRPVEAVPSSSLGKQPSVWKSVPSLGSDDVVPMEVCIEEDWNEVPEFYILDGDKKLGPEMWPVCMEVDGSEDWDLDEMILDECEAAMEELRNGVEDMDLDNIPPCQENQIFGFGYCPMEGVELEVQGQSFRHITSRQFKGNITMQIQLSIEMQLQEGPIVQETVRLNLITGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWE8</accession>
    <name>U4KWE8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Protein adg3 acc. no. O74851</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWE8"/>
    <dbReference type="STRING" id="1076935.U4KWE8"/>
    <dbReference type="eggNOG" id="ENOG502QWHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="290" mass="31282" checksum="9B3057DC811EB15E" modified="2013-12-11" version="1">MPEVPHPPPSLLLYVPSPTRAVYAFSQNGQGIVPVQVHGKNRGWALPPDRTCLPDMWCPYACPSGMVSTQWDPAATLAHPSRQNGGLFCNSQGVVVKPFPNQPLCKPGVGNVSVLNKASAGVSFCQTTYPGDKSPVIPTWIPANAKVGLGVNGPDYWMSTGTAYYVNYPGIPPEEACMWGTKPVQVAKGNWAPIQFSAQKDATGMTYLTLVHNLITWEPDFHAPLRNNFGVRIRCQGKCVTDGGLPCEINPKKHGLNHLNHEIPGGAGWANYCITTLHPGSTAVVEVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWQ9</accession>
    <name>U4KWQ9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_05238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935264">
        <property type="protein sequence ID" value="CCX05651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWQ9"/>
    <dbReference type="STRING" id="1076935.U4KWQ9"/>
    <dbReference type="eggNOG" id="ENOG502S7IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX05651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="317" mass="36353" checksum="4F01906C9BAB6452" modified="2013-12-11" version="1">MKVATDDDYIPFVGLTPTSDNDSQLSASQARVTYKPPPPSIFGGSEPEIRLRVEEDTTEEISARKHEATSETVEPTPAPFAVKYAHRNVRNKRSEVFDLLLKKKAATVKDKTKRTEQTEKYEKTEKAERPKYNEVKAAAETEDADEPLIQQRAGKWTLPSLDLDLEGPITKVQYQVLTLPTKDMAAWKIQKAALQKKFGVEGWNPIKKLSPDAMDGIRTLHAQDKEQFSTENLADLFKMSPEAIRRILRSKWKPSEQEQESRQERWNKRGEEIFTSMIDRGIIKTKSMKKKERKQRTARANWESVTDNAINISDKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX69</accession>
    <name>U4KX69_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
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                <person name="Gabaldon T."/>
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</entry>
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                <person name="Gabaldon T."/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXF2</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <comment type="function">
        <text evidence="9">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="2 11">Belongs to the polyadenylate-binding protein type-1 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyadenylate-binding protein"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
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        <property type="entry name" value="PABP_RRM1"/>
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    <dbReference type="InterPro" id="IPR035979">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
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        </location>
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            <end position="308"/>
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            <end position="705"/>
        </location>
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            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
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            <end position="405"/>
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    </feature>
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            <end position="633"/>
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        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
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            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
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            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX06155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="728" mass="79210" checksum="530672072A851254" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXF4</accession>
    <name>U4KXF4_PYROM</name>
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        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_06404</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
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    <dbReference type="eggNOG" id="KOG1315">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
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    </dbReference>
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    </dbReference>
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            <end position="37"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX06817.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="519" mass="57009" checksum="23E9AE47A7A037CC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXZ4</accession>
    <name>U4KXZ4_PYROM</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5480592at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="313" mass="34115" checksum="4270C4588C2C2410" modified="2013-12-11" version="1">MYTTSQWQKNLKKGQYCKISCPFALSSQRCAERRLYFPCRSVFLLRSSTSSPDESQKMNPFKYSGRPIPKFPHFAGELVAIKQEPLDEDDDQLDDGLTVQKDAEALAAVKQEQQETNALPPILYESHNAGIFSSSALGPQVSPVQVPALPEVQEPKASGESGAGAYVLPQWTAINKPRPTLTGPSASAVVTARPSVPTVPAKRAPAKKPSRARVDAVGISRPAPATGYQSSPPSQQRQEVPVPGSSVAPTPMEVQTAPQQEAKPTRASKRPRGPSIDDDASEPAPKKPAKKSSFGEMIAKQYREGERYDYWDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY07</accession>
    <name>U4KY07_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_06644</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY07"/>
    <dbReference type="STRING" id="1076935.U4KY07"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENYETKW"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="51"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="136"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="351"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX07057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="451" mass="50810" checksum="C490109A618CD0DD" modified="2013-12-11" version="1">MAATLSSRCLFRGLYTTPRVIPKSSTQYQTYFLKRGFASTMAFQKIKVKNPVVELDGDEMTRVIWDSIKQKFIHPYLDIDLKYYDLGIEYRDQTDDKVTVDAAEAILKYQVGVKCATITPDEARVKEFNLKKMWLSPNGTIRNILGGTVFREPIVIDAIPRLVPGWKKPITIGRHAHGDQYKAQDFVVPAAGTVELVYTPKDGGEPERIKVFDYKDGGVALAMYNTDESIRGFAHASFKMALDRGIPLYMSTKNTILKKYDGRFKDIFQEIYEATYKADFEAKKIWYEHRLIDDMVAYMLKSEGGYAIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHWRQHQAGQETSTNPIASIFAWTRGLIQRGKLDDTPELIKFAEALEQACIDTVNDGIMTKDLALSCGRTDRASWVTTQGYMDAVEKKLKTLVEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY56</accession>
    <name>U4KY56_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized protein C4C5.03 acc. no. O14166</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY56"/>
    <dbReference type="eggNOG" id="ENOG502QV5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FVIYFPR"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX06480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="32670" checksum="66D64A4A50860720" modified="2013-12-11" version="1">MESPLSAPAAECTSLLNPSVLNLVFSFVILFGILVSYLPQHIRIISRGTSEGISPLFLLLGVTSGTCAFLNILILSWGVLGCCSKGIGPFNCFAASMGVAQVGTQWLCFAIILALYLIFLPQPTGIPGGPQPATKKTAVAVSIGSIVHLAAMGAITLYLGALKGAPEDGAGDDPTRALHPSAALVNWANFLGVQSTVLASIQYIPQLFTTWRLKHVGSLSIPMMCIQTPGSFVWAISLATREGTRWSSWATYVVTGCLQGALLAMCITWEIADRKARRKAEVVAEAVAARGQGERQPLLQAQRTGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYD7</accession>
    <name>U4KYD7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYD7"/>
    <dbReference type="STRING" id="1076935.U4KYD7"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKTEGQW"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX04619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="447" mass="48828" checksum="16B82501F3A30F33" modified="2013-12-11" version="1">MRIHGLSSVLRTTLITASRPPRRIPHNAASASASASQARTFFNFGTSKPRLPTHLQQIRNRSNNSSTTSSSLPTQPPNPTSPSPFHFIPSHSLFAKRPPRPFPPPFHTPPTTSFSDPLTSHSLPGRSSRGGSQGARDLDPPEGGRHLRGTTNGDDAILTSPHYLAVADGVGAWNTKSHGHAPLWSRLMLHFWSLELCGGKFGFQRPAEEGGVDPVMSLQEAYHETFMATTNAGARRDQIWQGTTTVCGAVLEGNTVRVVNLGDSVGMVYRPKKAPTAQEIQEKEGAAKRTRWGRKVVEEKEEPGWLLRTKEQWHWFDCPRQLGTNSPDTPAGQAVVQEVEVQDGDILLLATDGLVDNMWDAEILQVIEEVLGEPEEVIEREAGTGGDAGRMKVLASRIVEQAKKTAMDMFAESPYMERSIDEGLGIEGGKWDDISVVAAVCRKGNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYF2</accession>
    <name>U4KYF2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYF2"/>
    <dbReference type="eggNOG" id="KOG3783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNGYNRM"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="698" mass="77565" checksum="3560E34EBE4EC71D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYG9</accession>
    <name>U4KYG9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to N-alpha-acetyltransferase 50 acc. no. Q6DBY2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_06608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935331">
        <property type="protein sequence ID" value="CCX07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYG9"/>
    <dbReference type="STRING" id="1076935.U4KYG9"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICCRLET"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="206" mass="22070" checksum="587373082AB49443" modified="2013-12-11" version="1">MPPSKLTTAPSSSGNNIAALKRLNSLLLPVAYKDSFYKEIVSSPSLSALSRVASWGETVVGGICARYEADTTPSRPLTTTSGNGLASSASSTSSSTSSSGASSPGEGMISPTGIVYNDGKIYIMTLCVLSPFRNLGAASALLKDVVETAKSWGIREVYAHVWTENHEALEWYGKRGFVVEEEVIKGYYRKLRPDGARIVKLMIPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYK9</accession>
    <name>U4KYK9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYK9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5404" checksum="039C6999D7EE4F63" modified="2013-12-11" version="1">MISIRVLPTAFTCKLHILRQLLHFPQDIMHMTLGARGFSPRDTRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ22</accession>
    <name>U4KZ22_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ22"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="3851" checksum="3958FB34D74EF88E" modified="2013-12-11" version="1">MLVLVSVGDRPCSVDVGPFLGREQAGWMDRSDGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ61</accession>
    <name>U4KZ61_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ61"/>
    <dbReference type="STRING" id="1076935.U4KZ61"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DCCEEAH"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX04934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="19321" checksum="E35B39A68089C7A0" modified="2013-12-11" version="1">MSSSNNSLALCVQSLQKCTSLLDSSIDIIDNGVRDFPRTAKVIQVSRYFECISEPALFEAQTALHDEIGPEVEHLLKRAEDYITKLDRREKGLISKAELQEGRIRQYQRDKPAPMPIDDDGKQERQEKMKALKIKRERLQHTIDRLSLQVVHKERQLRMRMNYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZA8</accession>
    <name>U4KZA8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935225">
        <property type="protein sequence ID" value="CCX04999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZA8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="536" mass="61166" checksum="7199FF096ACAE84C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZS6</accession>
    <name>U4KZS6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to S-phase delaying protein 1 acc. no. Q10585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX08020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZS6"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX08020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="188" mass="20497" checksum="6332E66A3D0F570B" modified="2013-12-11" version="1">MAPKPTPRKRQNIITADQAPITSFFKPAEKLRPELPEAIQSSLISVGMRVRKSVPEGYKSGSYAYNKHLPDVGGAPLTPPSESEMFSSQESNVSSLDASTTTTATANKKRALDYDDEKVAIDTIRPVQHAPASINQWARTVKAATKGALGGKKNRGFHQAVPRKDIKMTGAEDFEEADFLKPVDAMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZX4</accession>
    <name>U4KZX4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX07779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="131" mass="14251" checksum="A9435E6005AF3911" modified="2013-12-11" version="1">MSGVAMAADIYLLLLTRLRIVRASVSVTICLSLVLWETQASGLVCDNLSWRIGNGYDGGEIIEKSLVMITARVTVAPFSRVMVTTTNDGLPGEYGYAQFCGVDGPKDPQQTQDAAPLKGQFALWIVWPTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L026</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_07897</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX08304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="250" mass="27721" checksum="BC3F507CAF0EA0CD" modified="2013-12-11" version="1">MAWPPSQDPDLADDEIPQEILALTHQLHASTQATRRENTLLKARNQELILQYERLAKEKRLLSEHVTELEQELFEEQETTQDLRREIQKLSLVMDEIGERGTECQQQLRLARGENDKLSAVIDAQLEEIVNLRGENEGKVRIIAGYDKIVKDSLSTSDRAVGRLKDVIEKQLGEIARLKAAQKEAKASKSSTSPRPPPPPPPPPTPPPTSPPPTSSPPTSPPHASPPTHSPPPPHSTPPCPHVEDAEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0C3</accession>
    <name>U4L0C3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX08009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0C3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="19" mass="2243" checksum="9D95084CA4B370E7" modified="2013-12-11" version="1">MKRNSVSAWHPRGCLQPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0E1</accession>
    <name>U4L0E1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized protein C29E6.02 acc. no. Q09856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_05061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0E1"/>
    <dbReference type="STRING" id="1076935.U4L0E1"/>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAMQPKF"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="188"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="562" mass="62252" checksum="33B500B572A35BE9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Y4</accession>
    <name>U4L0Y4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to homeobox and C2H2 transcription factor, putative [Penicillium marneffei ATCC 18224] acc. no. XP_002146929</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Y4"/>
    <dbReference type="STRING" id="1076935.U4L0Y4"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <sequence length="63" mass="7390" checksum="B3DB930A148D284D" modified="2013-12-11" version="1">MVYGNETTDEFLQMPVGVERKPRLKGTKSGTNVILHRRKERERRTIYEQICNGKTYGNMDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2L4</accession>
    <name>U4L2L4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935291">
        <property type="protein sequence ID" value="CCX06498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2L4"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="452" mass="50146" checksum="ED9F8A7AF140D00F" modified="2013-12-11" version="1">MAKRKKSNKSQNQQNQNQKRPRNDDGEHKNNQFAGSHGYIDPVTGQRGAFPGLDGDEDFFGPPMDGMDYLRMVRSEAKGVPALLLSASALAKAPPIPRERPQPPTPKRPAMPIEKDVILDYDDPSPVPTAEVPGSDEIPELDPEPEVDYDATFLFTESTSISLLPSAPATPLPLTHHITIQKFHKLRSNMASYLSPQKGPMPGWMDNRIIRQWLTHTPPKTGWIAAMRQGEILKMIKAFTYWMQWRVKVRNTATRGVARCWMLWIWGLLGRFEETRAADESVVVRELGKAAVASLKALKEGIEAAEAEAEEEYEEEVLEEEVTEEAAAEGDDGAYEPPEFMGEPSNAEVTMSAKPAAEEPEEGELEEGEEMEIEVAKPVEAPEEGEEGELEEGEEPEPKTEAPKQAASATTVEVDHQVLSIEDTMASLDMIISIVGDFFGQRDLLEDRAAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2T5</accession>
    <name>U4L2T5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2T5"/>
    <dbReference type="eggNOG" id="ENOG502SD1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13357" checksum="82B1D12FF046266B" modified="2013-12-11" version="1">MSTGIPNLGNADITGSAHNGRRPSQVHGHIEYAKGVVSETIGSMVNSSSWQQSGESHKASGIAEMRSAKEMVDKDLRSHYPERNATTLKTEGKSQNMLGKTIGCQGMVERGGEKEQIGDMLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3B3</accession>
    <name>U4L3B3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935314">
        <property type="protein sequence ID" value="CCX06803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3B3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="17570" checksum="FBA6CAE9374A7095" modified="2013-12-11" version="1">MSQVATQEDLSFTETRIPSTPPTPASVVGFPTALHQPPHIFTVRRYFTTTCFQAAPNAANKMAYPTSLTMLAEMIVALFKYSILPILILFLATPIFQHILERFIAKRMPGPANANTDGMAAELDRNEMDSATTTGTDADTFDEGHTTVDDRYIRESVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Z8</accession>
    <name>U4L3Z8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935574">
        <property type="protein sequence ID" value="CCX10906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Z8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="144" mass="15465" checksum="8DD0589F0C26C76D" modified="2013-12-11" version="1">MTVARPVRRFGGHLDRPPWATGGRKKCNTITACLARFDLGYLHLGACPAVVWSLMVGSSCSRIVCVARECQWRGAMFAFFSSPCMNQQATRSETVGNAAFSEAETCLECQNSVGGGVIPEMSASLEENPSSPGSPPLYSRDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L467</accession>
    <name>U4L467_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Metacaspase-1 acc. no. A6SDT7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935547">
        <property type="protein sequence ID" value="CCX10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L467"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TICTDIC"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="197" mass="21409" checksum="89345DD016CA2BAD" modified="2013-12-11" version="1">MTICTDICLSITFLVVFRVDPLKPGVRLTAVFDSCHSGSVLDLPYSYESSGKQNHSRGVCQFVAAHLSSALASYAKGVIDLKGIKRGAWFIKKRLTTNRNAEQKTVSTKSSPADVVQWGGCRDNEVGCGMSYGKPIGMMGVMTHSFVSAVSENPQQSYAQLLKSIRDRCVKEGNPKHLQIPQLSCSHPLDTGSPVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L476</accession>
    <name>U4L476_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Protein yciI acc. no. P0AB56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L476"/>
    <dbReference type="STRING" id="1076935.U4L476"/>
    <dbReference type="eggNOG" id="ENOG502S8X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FAKEGIW"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="135" mass="15203" checksum="B9F4460CB1DE18A9" modified="2013-12-11" version="1">MYKYIRPATSFLSKLHPIRKMSSTSAPPKIEWLCILPDQEGARERRLATRPRHFEGIGALVNSGFLTMGGALLNEPPKDGNPQNFDFSGSVVVATGETKEEVIEKLKQDPYTTENVWDWEKAQIIPFLCAVRQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4G6</accession>
    <name>U4L4G6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_11551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="HF935656">
        <property type="protein sequence ID" value="CCX11957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4G6"/>
    <dbReference type="STRING" id="1076935.U4L4G6"/>
    <dbReference type="eggNOG" id="KOG1182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="11">
        <location>
            <begin position="130"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX11957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="470" mass="52735" checksum="EDA9E72FDD1D6DA6" modified="2013-12-11" version="1">MRVPISRSLCALSRSQPSLCPQSRRALLSSPGVRSLSSRFTTPRSLSYTATRSLSSTASRNGGIRQAPDSDSVSFPGAVKSKFTHKLEFHRPQDMPAMNTYRYINAEGVVVDTERKLDIDKNMARKMYQDMVRTSIMDLIMYDSQRQGRISFYMVSAGEEGIAVGSAAALEAEDVLYSQYREQGALMYRGYTLDEFMSQLFASKDDYGKGRNMPVHYMSEKLHLHPISSTLATQIPHAVGAAYAMKMENAQSVVACYFGEGAASEGDFHAALNIAATRDCPVVFICRNNGYAISTPTLEQYKGDGIASRGIGYGIETIRVDGNDIMAVYAVTKAARELASKNQKPVLIEAMSYRVSHHSTSDDSFAYRAKVDVEEWKRRDNPITRFRKWLEAKEWWSDDEEVAFRTQARKDVLTAFAKAEKAKKPPLGDIFTDVFAEMTPELKEQRAQLKAILEEYPDEYELGEFDNSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4R6</accession>
    <name>U4L4R6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4R6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="9841" checksum="293A2784CF8728DF" modified="2013-12-11" version="1">MAESSSSSSSSSSESENAVVAPAQPAQPANNPPLLNDIIGLYKANLSWDKPWRQRCRRALGLSKRDKSRRFWAVINIFRLICCDLEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4T6</accession>
    <name>U4L4T6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to KN motif and ankyrin repeat domain-containing protein 1 acc. no. Q14678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4T6"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10751" checksum="9CDF73F17C3C0232" modified="2013-12-11" version="1">MCIAAFLDEDVVRRLLELRDIDINTQDNEGDTALMCAIHDGNPVQLVESVHLVLERHDIDVNLQSNDVIEFGLKEAREDEIWLSWIWDDGGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4X5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="5904" checksum="C388FC3BCA3856D7" modified="2013-12-11" version="1">MRPTVHGDAGSRLMYSIVHSRRCTLTRGFSKEFAPLTGASSKIGLVYEDVIFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L596</accession>
    <name>U4L596_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin-3 acc. no. Q12955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="303" mass="33248" checksum="771C15B10F15DD53" modified="2013-12-11" version="1">MNTTDIIMKFVKDTASELSLNVISAYAKNPLFGLKRVYFLPSSGWHPLHYAVFLGHTIALNNLLGAENANASPPSKNKQTPLHVALDYGRGSIALLLISRGANVNATDFRGKTPLHLALSTARNDDMAKFLIENGENVNVSDRFGVTALHFAAKLQIKSMVQILLENNASPNVMDNYGRTPLHIAVILRNSDVMRILIDNKADVCAVDKDGDTPVNLAMRKGNLVHDFDLSESESSEYEYSNPESRRSKASYCTIASTVYESTGFEDPPQNKMALLLIDSGVNRVSLIRTVLHPCTGPCGKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5A1</accession>
    <name>U4L5A1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5A1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="43" mass="5027" checksum="795CAED377524487" modified="2013-12-11" version="1">MTLVYGVWSESCRFWKSIQKLLYSREVALLGPPNSLRLRIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5B2</accession>
    <name>U4L5B2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Oleate activated transcription factor 3 acc. no. C5DUX2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L5B2"/>
    <dbReference type="eggNOG" id="ENOG502QQCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNGASTM"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="677" mass="74714" checksum="EA0B3F8EB1ACA7B7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5D5</accession>
    <name>U4L5D5_PYROM</name>
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        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_10947</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX11353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L5D5"/>
    <dbReference type="eggNOG" id="KOG0771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPQLAIF"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="471"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX11353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="517" mass="55816" checksum="8A918E3EAE34ADDE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5L0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5L0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="17" mass="2104" checksum="3279C7D99B47FECF" modified="2013-12-11" version="1">MIEYSSTELRMQVEMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5N5</accession>
    <name>U4L5N5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935678">
        <property type="protein sequence ID" value="CCX12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4717" checksum="31716C76CBA7F9B5" modified="2013-12-11" version="1">MHSRQCTPTLSAIELELVRRDFVPSASLNFVEIYKCATKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L704</accession>
    <name>U4L704_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935789">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L704"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="2012" checksum="15B9D0DC65499724" modified="2013-12-11" version="1">MQSCDWGVTLAHMASLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7P9</accession>
    <name>U4L7P9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935723">
        <property type="protein sequence ID" value="CCX12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="181" mass="21178" checksum="62328A194B7D9812" modified="2013-12-11" version="1">MANTKKPVQPSRQPRSVRGHDGAKRSMDTNSAVTKKTFARSLHVKTVKGYEITKRDIETNSVLRGKIAALEQIGIYPDRPYTEMQYDEPNYSKLITDSPSVIEKRLEETLTKSLVTPNTVISLPDDMRMGHRLGLMYYNELEKEQKKKEREKEQLEFEEDMRLIQRLKRKNFDQRDNDSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8E3</accession>
    <name>U4L8E3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8E3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5513" checksum="FFA028154A6EBF2F" modified="2013-12-11" version="1">MSKYIATTAGCLLSSGCYRMLSSFKRVQSKQSLDALTPIHIARGYCVLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8G3</accession>
    <name>U4L8G3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8G3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="21" mass="2448" checksum="F95F0D9A48823066" modified="2013-12-11" version="1">MFVEVTLVLHTYADIALLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L900</accession>
    <name>U4L900_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to FAD dependent oxidoreductase, putative [Neosartorya fischeri NRRL 181] acc. no. XP_001258479</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L900"/>
    <dbReference type="STRING" id="1076935.U4L900"/>
    <dbReference type="eggNOG" id="ENOG502QRBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAWLCGT"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="505" mass="55045" checksum="CC6BBE35829ACE85" modified="2013-12-11" version="1">MGNIISPLSVSLKHLRTTKSSYASILDRLNTAPGKPVAAPTASAWQSPPAPLANFCSEEFPTEVDVLIIGSGITACSIAYHLLRQDGPKPRVAIFEARELCSGATGRNGGHIKESPYNEWARLVARFGRIAADEVVRFRMAHLKNLLELADKEGLREVSEAREVETVDVYCEPEAWTKAQQRLREWLDAFPDEKGRWRTWEGADLKTKFNLTTACGCITSTAGSLSPYALITHLYQRLLTTYPTLSLHTNTPVETLQGTPVDPWRRPISPLQPYSVFTFTGSSATIKATHVVHATNGHVTRLVPGLKGKLIAARAQMTSQRLMPEGVGLPGGADRSWSFCWNKGFDYLTIRPDGAYMLGGGFARGPSEGLEAMGNAKDDENTIYEAAYLGGLLPAVFQGTVKGTVIESAWTGTIGFSVDSLPWVGAIPEKVAGGRRRGMGMEWICAGYSGEGMVNAWGCGRGLAVMLRNELYKENASTGVPQAMLITEKRVKKATVEMMVEDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9U8</accession>
    <name>U4L9U8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_13917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9U8"/>
    <dbReference type="STRING" id="1076935.U4L9U8"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PGTIPHG"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="310"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX14324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="477" mass="53468" checksum="8A01DD86DB36234D" modified="2013-12-11" version="1">MLAENYQKIFHWAETQKNGEIPSFKTRKNDPYTYQCGFGNSFESEAIPGTIPHGQNNPRKLRFGLYAEQMTASAFVAPRSHNQNAYLYRVRPAVAHQGFTDLPDNKDTESCFLPINPRVHVSPTQLAWLPFELPKDTEKVDFVQGLKTLAGSGEPTLREGIATHIYTANVSMEKRAFVNSDGDFLIVPQQGTLDIQTEFGPLFVQPGEIVVIQRGQRFRVSLPDGPSRGYILEIWGSNFALPELGPLGANGLANKRDFLVPNAAFEITDDHWDIVYKLGGKFFSSSQEHSPFDVVAWHGNYVPYKYDLTKFVNVGSISVDHIDPSIFCVLTAPSRDPTAPLADFLIFSPRWDVASNTYRPPYYHRNVASELMGLIYGDYGGRSDEFQPGGASFECGMVPHGVAYPEFKAASDAAPPEMRISEGAVAFMFESSRAFTITDWAWNSDKKHEHDPKMWDDLVAPQIEELKKLQAEQNAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAG0</accession>
    <name>U4LAG0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_03005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAG0"/>
    <dbReference type="STRING" id="1076935.U4LAG0"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="443"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="957" mass="106814" checksum="695553541A8BB41E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAV3</accession>
    <name>U4LAV3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAV3"/>
    <dbReference type="OrthoDB" id="10436499at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="163" mass="17655" checksum="46470BF22512A1D0" modified="2013-12-11" version="1">MPIPLYVNQASAAASAAAPVFQLQQVPQHPGYHLALHNAGQAQLVPADAALQAAMVAQAPPAMPAQVPAQVAAVVPPFAVSIAAAPMPVQIQAPPVQVALADHKYLVYRFAPTEEHPFHHWKYFPQETSQDQLPDIRIARPLYIWSSNTGEYTPVQVIMSQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBI2</accession>
    <name>U4LBI2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_03321</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF936487">
        <property type="protein sequence ID" value="CCX16622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBI2"/>
    <dbReference type="STRING" id="1076935.U4LBI2"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="523"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="708"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX16622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136215" checksum="4F95E25883E6CD92" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBS6</accession>
    <name>U4LBS6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBS6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6002" checksum="73C21E4A11DB95D7" modified="2013-12-11" version="1">MGRRLVKCGVESLASSRIQGSHGVASDPLSHMCAVKCNWCPNESGPSMRACWLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBX4</accession>
    <name>U4LBX4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Aldo-keto reductase yakc [NADP(+)] acc. no. Q09923</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBX4"/>
    <dbReference type="STRING" id="1076935.U4LBX4"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPHHNEE"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="339" mass="37671" checksum="7960E0BE81AB06BC" modified="2013-12-11" version="1">MSLPTRTLGRDGPTVTGLGLGCMGLSAFYGPPPPDSERLAFLDRAYELGLTFWDSADIYQDNEDLLGQWFAKTGKRSEIFLATKFAINKSGNGPFIRGDREYVRQSVEKSLKRLGTDYIDLYYQHRPDPATPIEETMTELVALQKEGKIRHIGLSECSAATLHRASKIGKVTAYQIEYSPFFTEIELEEIGVLKACRELGIAIVPYSPLGRGFLTGKYKSIDDFPEDDFRRAVPRYNVKENFDKSLALVDEIQKLATVKGCTVGQLTLAWILAQGDDFVPIPGTTKIANLEENLGALKIQLSKEEEAQVRKAVDAAGHTGERYPKEMMGTLFGETPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC92</accession>
    <name>U4LC92_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_03099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC92"/>
    <dbReference type="STRING" id="1076935.U4LC92"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DEFELWG"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="157"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="321"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX16456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="838" mass="95653" checksum="741E1A39BBD16B98" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCC3</accession>
    <name>U4LCC3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Calcium-independent phospholipase A2-gamma acc. no. Q8K1N1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCC3"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="27"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="782"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX12068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132424" checksum="8F75349628FC7542" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCJ7</accession>
    <name>U4LCJ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative alpha-ketoglutarate-dependent sulfonate dioxygenase acc. no. B5BP48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_07120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCJ7"/>
    <dbReference type="STRING" id="1076935.U4LCJ7"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSHMQNY"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="88"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX29794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="394" mass="43956" checksum="522C9671EDB73540" modified="2013-12-11" version="1">MAPAVVIAPTDEPIIQSVKQTSAPAKPRFTPGYSEVEPAPEVYEYEHLKQAFPPLYWPALEEVPYEDKGKLGDVNYKDLLANASDCFDYHPKIGTEVHGVSLKTLTDAQKNDLARLIAYRGVVIFRDQHDFTIEDQLNLGRYFGTLHKHATTAVPQQPGLEELHVIWTDGNSADQRALFTPAHLWHSDVTYEIQPPSYTSLKILCGPPRGAGGDTLWSSQYAAYDLLSPHMQKYLEGLTAQHSAEEQATGSRALGRPVRRDPVTTEHPLIRVNPVTGWKSLFYSPGFVTAIIGIPKMESDAIMAYLDNVIVATQEIHARYQWSPGMVAFWDNRTCNHSATYGFAPHRRHAVRVTPHGEKPYFSPEGKSQEEELLAAAGRPPVNKDGARQSNYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD06</accession>
    <name>U4LD06_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD06"/>
    <dbReference type="STRING" id="1076935.U4LD06"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIAHRTY"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="331"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX08389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="705" mass="79589" checksum="0870F9BD8285938B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD08</accession>
    <name>U4LD08_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Cellobiose dehydrogenase acc. no. Q01738</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936578">
        <property type="protein sequence ID" value="CCX17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD08"/>
    <dbReference type="STRING" id="1076935.U4LD08"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IGYLQCA"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651345" evidence="4">
        <location>
            <begin position="20"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="777"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="813" mass="86739" checksum="A98618E6E5A71263" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEI7</accession>
    <name>U4LEI7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935487">
        <property type="protein sequence ID" value="CCX09689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEI7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="86" mass="9916" checksum="1E03198AC7774602" modified="2013-12-11" version="1">MVDWSIRRMDGWLLKQMLERDEEGPCDMQLVSGWMLNLRMVDFVGVLVGAFWYDFLGDERGLELLWIRGSGLCVVSATISFGVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF00</accession>
    <name>U4LF00_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF00"/>
    <dbReference type="OrthoDB" id="5497808at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="209" mass="23151" checksum="17FCBEE8BC39392A" modified="2013-12-11" version="1">MPSMYEERFRSEAIAISRVVLSDSKQRNLRAHLVTPYDETEPPRREIDVSVPLSQRSRTFRLSGIPGDVTQELLSLYLDGLDVGDEEGTSLTGNSTVSSLVPYKSWQVATVSFDREPKEFRQCKPGKASYLFVQSLQGVGASTASFEIVADCDFYCLTPLYQSPDAIKYDIIAVTGLSGHAFGSWKSTDLQMMPLLSSIYVGLLFQSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFT2</accession>
    <name>U4LFT2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFT2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="18051" checksum="DFC5BF360F2E70C4" modified="2013-12-11" version="1">MVASFFEKGITDSTIAIDFCKLYLDSLLVALAVPRRTKAEACTALIQSHATQPTQIIATDLLAYFPFFKTTSLTFVLRRSLLSLLYFLSRYTRSIQSLESAYIRRKKKIVKEEDHIATPTNTPDISQASKEQFRDKYQLYQLKRSRPPCFPAFQVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG41</accession>
    <name>U4LG41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG41"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651342" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="148" mass="16138" checksum="8FEACA63A139F19B" modified="2013-12-11" version="1">MHLSTVLLTLSLTATSLASFCYPTGNSALTSAVTARHRQFCTYASRYSPINPGEKVSFTYETTLPNGAPGRIFYQYHNKSNKKWYILQTPCEADIGWDLDGGCAGYAGYHECTSSDDVSGDTTACVEGMGWDLDLQLQVEQGRASKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG84</accession>
    <name>U4LG84_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Membrane protein TMS1 acc. no. Q12116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936108">
        <property type="protein sequence ID" value="CCX14994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG84"/>
    <dbReference type="STRING" id="1076935.U4LG84"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DKHCNPL"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651346" evidence="8">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX14994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="479" mass="51977" checksum="2B4CB4AB6413A7CA" modified="2013-12-11" version="1">MGALLSIPFLAVPSLTTIGSFAASCCGAAACSAICSLCGKCQSSTATRIAYALIFLVNSILSWIMLTPWAIKKIEHLTLDTLPISCFGEQCWGFVSVHRINFALGVFHTVLAILLLGVRNTKSGRATIQNGYWGPKIIAWLALIVLTFLIPEKFFIFWGNSFAMVGAMLFLLLGLILLVDLAHSWAETCLANIMETDSRVWRWILIGSTLGMYIGSLVLTIVMYIFFAGSGCSMNQAVITINLLLFLIVSFLSVHPTIQEFNSTAGLAQSAMVAIYCTYLTMSAVSMEPDDKQCNPLLRARGTRTASIVLGAIVTLLTIAYTTSRAATQSPALGRSSSPSNGGYSALDSNEHGLVTTEPTRAQMRAEALRSAVESGALPASALDDDSDDEDSGRSGDDEKYGTQYSYAFFHVIFILATAWTATLLTMSIEPGKGEEEGFQPVGRTYAASWVKIVSAWACYAIYVWTLVAPWLFPDRFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGD9</accession>
    <name>U4LGD9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX30968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7423" checksum="837B1CE6DF1B1EBF" modified="2013-12-11" version="1">MVLCGILNGAKTEGECTESGRLEATRAYPLSWPTVCILNVVPLIALLVKCPCSKMHFPLKLPSTHDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGT3</accession>
    <name>U4LGT3_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Pentatricopeptide repeat-containing protein At5g01110 acc. no. Q9LFC5</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">PCON_10572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGT3"/>
    <dbReference type="STRING" id="1076935.U4LGT3"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="642" mass="73114" checksum="EF75BD3F095CC990" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH36</accession>
    <name>U4LH36_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_04205</name>
        <name evidence="3" type="ORF">PCON_10931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <strain evidence="3">CBS100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935224">
        <property type="protein sequence ID" value="CCX04991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF935612">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH36"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="394" mass="43316" checksum="9602CF2204FD5443" modified="2013-12-11" version="1">MTAAITVSTPPPQSRRQQNVARTPNRQTKTEHYTNISFAPNNVKNVNDAGQQQVPNSKLQYSPQFDASRGRHSSPAKAPPRTPQHSTDKKKRRTRKPKDLVKAPAPDSTLSDSAASEHTSPLATPTHFPDSPSKAYAGSGFHQSPAPSALPIPKFFSKSVPSNIASARLFQDDSDSVSVSPPSNTPLDMLFKAHAAEIARKRSNDSSDSDSATDRDIFGTATPRRPLAAPHQDAQVRPAPSRAVTDSFVMEDLFKSLPSSPAPNSTPYSIPSQHKGDLYQYLARSTQPNSAPSPTPQYRGRTAVNNYGSPLRAPPPRQMYHTPEPPKSPEYYTPLTSPLRSPEPQYNCPPQFPNMFEVRSDNIPCGMDDNTMQKENKLREMLNMAPRVIHGVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH77</accession>
    <name>U4LH77_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH77"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6695" checksum="7FFE8F930ED8A6FC" modified="2013-12-11" version="1">MDHLTRHPVLSGKYQIYYDSDPRIRKSTLLLSGYFLDRLAAVLSCMLQLCLAKTIDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHY4</accession>
    <name>U4LHY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935644">
        <property type="protein sequence ID" value="CCX31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="21347" checksum="C6E3BB6B0B37732E" modified="2013-12-11" version="1">MNFHGETITETASRRGVCQVWERALKRFGYDAKGIIAADLGVGLTHCSIDGTLVKGARKVDHDPEFICNLCSLGESEWEEDSRKCEEDWPWNPKWPQWDRRPRERYYSAIRRGYKTTKECYYDDSDDYIIDEEYEAEFSEDEDEEDEKEEIGNEDCKKPCVEVEEQCGSSNIDRDNQSTSPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI20</accession>
    <name>U4LI20_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI20"/>
    <dbReference type="eggNOG" id="ENOG502SKCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5362630at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="678" mass="76788" checksum="0D157ED1C8E1416D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIY9</accession>
    <name>U4LIY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936502">
        <property type="protein sequence ID" value="CCX16709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIY9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10583" checksum="93C0EA7799043224" modified="2013-12-11" version="1">MDQTANMDGDQIFVDEIQQEESEQMITSSSCAENIATDNEEDGGDSYDVESSSDDDVETDSNSSDYGDDIWTDTDFLDDNDDGVTDERDIYYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK57</accession>
    <name>U4LK57_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_12931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935809">
        <property type="protein sequence ID" value="CCX32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK57"/>
    <dbReference type="STRING" id="1076935.U4LK57"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="196"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="491" mass="53513" checksum="3B787A5C4CCD0859" modified="2013-12-11" version="1">MLRAIPRLRAAKGSRRLFSTARLTKKQDVSELDCITTLPNGVRVATEALPGHFSGLGVYVNAGSRYETDKLRGCSHIIDRLAFKSTSTRSASSMLESLERLGGNMQCASSRESIMYQSAVFNTDVPSMLGILAETVLDPVITQSEVEEQLQTAAYEISEIWAKPELILPELLHSTAFQGNTLGNPLLCPEERLQHITADTIKEYRKQFYTPERMVVAFAGVEHDAALKLAQQYFGHLPPSPAPGILSSLLTPKQAAHYTGGLLTMPPSTVPTHLPSYFHLHLAFEGLPITDPDVYALAVLQTLLGGGGSFSAGGPGKGMYSRIYTNVLNHFGWIESAVTFNHSYTDSGLFGIAATCHPEAGHALINVLLKELQSTISGGYKGLDREEVERAKNQLRSSLLMNLESRMVELEDLGRQVQVYGRRVSAQEMSEEIKKLRVEDVRRVAERVLKGGVQNPGKGKGGPTVVVQGTEKAVQDMGDILGTVRAAKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKA7</accession>
    <name>U4LKA7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKA7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6763" checksum="B98E1503446BBA9E" modified="2013-12-11" version="1">MTAVESQYMETSTCEAAPRQQSRRHHSTTTFNIAKIVVRQAAADPTTPPWIDIRAFRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKG1</accession>
    <name>U4LKG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Suppressor of glycerol defect protein 1 acc. no. O13971</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <tissue evidence="6">Vegetative mycelium</tissue>
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        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LKG1"/>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
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        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
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        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="782"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
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            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="57"/>
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    </feature>
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            <end position="84"/>
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            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX13151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112781" checksum="A09E993A02305612" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKG9</accession>
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            <taxon>Pezizomycetes</taxon>
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                <person name="Altegoer F."/>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="GH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="17"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKP5</accession>
    <name>U4LKP5_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1850"/>
        </location>
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        </location>
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            <end position="668"/>
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        </location>
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        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
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        </location>
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            <end position="1061"/>
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        <location>
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            <end position="1114"/>
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        <location>
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            <end position="1125"/>
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        <location>
            <begin position="2064"/>
            <end position="2074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2204" mass="243432" checksum="A9EED33949AA1AB6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLK3</accession>
    <name>U4LLK3_PYROM</name>
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        <submittedName>
            <fullName evidence="8">Similar to Isotrichodermin C-15 hydroxylase acc. no. O13317</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">PCON_08361</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="371"/>
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        </ligand>
        <ligandPart>
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        </ligandPart>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="49236" checksum="CA2E92349D5DED49" modified="2013-12-11" version="1">MDHESTPREIWPCCPHCAQRLVVLHPTSYRDINKSKVPFPKTEFFDAIDNGFNEAGIGTERDVEKHLRKRKFLTPAFTPAATKMYEPLVAPHLDSFLKEIEERGKLPEGVDFVEWYQFLTFDTAGDLAFGESFKALSMGVQHRWMSLVTESIDIAAYLEATRRFPVFLAIFQKFIPAKITEARKWHVDWSKQQTYRRIANPSSRGDMLGFMVDSEGKTSISHDELTAHASQLILGGAETMTGMLVGTTYFLAKTPRVQQFLQKEIREAFESVDDITAAKLSTMKYLTAVIHEGLRSFPPGPTGLPRYSPGALVDGHFVPKGTKVSTHPWTVTHSEEYWDKPDEFRPERWLEEGNKDVKDASVPFGLGTRQCLGQNIAWVEMRLYLAKMMWLYNLELVDKERDWVKDCKTYFMWMKTPLMIKVERREGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLR0</accession>
    <name>U4LLR0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 60S ribosomal protein L23-A acc. no. P0CX41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLR0"/>
    <dbReference type="STRING" id="1076935.U4LLR0"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="140" mass="14724" checksum="F0883F2E975B521A" modified="2013-12-11" version="1">MSKRGRAGAAGNKLKMTLGLPVGAVMNCCDNSGARNLYIISVTGIGARLNRLPAAGVGDMVMATVKKGKPELRKKVMPAVVVRQSKPWKRPDGAYLYFEDNAGVIVNPKGEMKGSAITGPVGKEAADLWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMG4</accession>
    <name>U4LMG4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_01524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMG4"/>
    <dbReference type="STRING" id="1076935.U4LMG4"/>
    <dbReference type="eggNOG" id="ENOG502SYNQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="402" mass="45082" checksum="2C0C6716E3BB6F16" modified="2013-12-11" version="1">MFRQPLLRSTQHLPRPLHLTPGPLWSRVISPFNTSRLCPPWIRTYARPSPRSYPSPQVKQLKTASPEELPDKRQEQERIAELENALKSGVYDRDPTGGKTKALTIVFGVVAASITILLQFEESRVNPPILPDEFRPYANLPLNTKLWRSEPRVAINLFFHRLRCGQYKSTILNNVSFSAAEYLGYNNDGTKSTEPWKWWTWGTHMVGHYSIIHLGMSIMVFHNVCSALVPMYGAARTMAIFTLGGAGGAAAYCGIQSWLNGERLKSGDAVRVTRVEKTIRDENGVIRTMRYLQQEYAPGMRNMFIRNLGASGGLMSLFTVTAITMPQIKWGLPFLPFSFGTRSMLAGVMAFDLVGLSGFLGNTGIGHAGHLLGDVAGALLYLLWLRRLPVSRFLKQRRKAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMV6</accession>
    <name>U4LMV6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized phosphatase C823.14 acc. no. Q9P6N2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936097">
        <property type="protein sequence ID" value="CCX33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMV6"/>
    <dbReference type="STRING" id="1076935.U4LMV6"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VPFHEFD"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="257" mass="28611" checksum="539DA0660A70A58E" modified="2013-12-11" version="1">MTTVYDPAHTLDKTHPELLQKKFIVFTDFDGTITRTDSNDYLTDNFGMGFAARRKLADKVLTEELTFRDAFKQMLDSVAVNKSFDECRQIVVDKIELDPGFKVFLEYCLSQDIPVIVLSGGMEPLISALLQNLVGPNEIPIVSNGAGKSPQGTWEITYHDDSGFGHDKSLAIKPFTEARKNLPEGERPTYFYCGDGVSDLSAAKETDLLFAKEGHDLINYCKSSGMPYRVFKDFSTILADVKDVVEGRKTAAEIAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMW8</accession>
    <name>U4LMW8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Dihydrosphingosine 1-phosphate phosphatase C823.11 acc. no. Q9P6N5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936097">
        <property type="protein sequence ID" value="CCX33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMW8"/>
    <dbReference type="STRING" id="1076935.U4LMW8"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="48035" checksum="07FA9F9EB0038871" modified="2013-12-11" version="1">MIMLPILFWFGYTTLARGVVHVLASGVFFSGFLKDLLCLPRPLSPPLHRITMSGSAALEYGFPSTHSTNAISVALYGLLVLYATPEVTAKQRILCESLALIYSFSIVFGRLYCGMHGFLDVIVGILLGALIAVLQWGFQDKIDEYVFGESFWPIAVCIITILVLVRIHPEPADACPCFDDGVAFAAVTAGVEIAGWHYSKTRFSWDYPVLGTVPYSYGDLGLVKSGLRVVIGILIVFLHRSLLKPLLHFILPPVFRIISRLGLSLPRKHFTPATSYKAVPQLPDDTLPGLNELPGLVRSIRRARSDSVGPQSVADAYETLAYREKRRRESVSKDGGVGGVNGMNGNGGNGNGAQGTNGIQRYENEMGTGGVDMDTLRNEAEEREVWRRVEVNRPRVRYDVEVVTKLVVYAGIAWWAVEGSPVIFEMVGLGCGERKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN36</accession>
    <name>U4LN36_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Choline/ethanolaminephosphotransferase 1 acc. no. P22140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN36"/>
    <dbReference type="STRING" id="1076935.U4LN36"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RMYFILW"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="493" mass="54959" checksum="6EE1E389E72EFE38" modified="2013-12-11" version="1">MPSRPKPSWVDTRAMPPPKTLRNGANDLSKKRSELPEEQLVHLKSYRYQSVDKSWISNNILRHYWNFMVELLPLWLAPNAVTLLGFGFIVANVCLLEAYIPDLVGPAPSWVYFSFAFGLWAYSTMDNIDGKQARRTGSSSPLGELFDHGIDSLNCTLASLLETASMGLGATPAGAFTALIPCLPMFFSTWETYHTHVLYLGYFNGPTEGLIIACLLMIVSGIFGPQIFSLPMRETLGDWVPYGHLNFLDVWIPIVSGAFLFAHLPGCVLNVVAARRKANLPILPVFLEWTPIIIFTSAICAWLGSPNTSLLSENRLVLFCVTLSFVFGRMTTKIILAHLTKQPFPYWTVLLLPLVGGAVLANLHIIGMPSISADFELLYLRSYLIFAIIAYSRWAVLVINSICGYLGIKCLRITPKKNVMPLVGGVGLETSVFIDSGYYEDSGRMGKKEEDKGRMGIEEGGRIMEEWDKNEEEMEYTGKRGNTVMEEEDNDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN48</accession>
    <name>U4LN48_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN48"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="52" mass="6010" checksum="F723469C85AB47EB" modified="2013-12-11" version="1">MKRCNFTKEIVGLCEHVRRYAPGFLSDFGAATFLSALHHHPSMRITHSYDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPV6</accession>
    <name>U4LPV6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized RNA-binding protein C4F6.14 acc. no. O74400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPV6"/>
    <dbReference type="STRING" id="1076935.U4LPV6"/>
    <dbReference type="eggNOG" id="KOG0127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTHRHAL"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12413">
        <property type="entry name" value="RRM1_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="138"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="292"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="745" mass="83536" checksum="ECFEAE901682D154" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR86</accession>
    <name>U4LR86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein NIF3 homolog acc. no. O94404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR86"/>
    <dbReference type="STRING" id="1076935.U4LR86"/>
    <dbReference type="eggNOG" id="KOG4131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NFDKTHL"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32719" checksum="58AB9EAB5E0D752B" modified="2013-12-11" version="1">MSNSLRSPVVRTVVNSIQRLYPSAIADKTWDNTGLLLESPHRSDLVASRPKKHVVLLTIDLTRSVVDEAIALRSSMIITYHPIIFRPMKSLTFADSQQESLLRLAQEGISVYSPHTAVDATIGGVNDWLAEGISGGEANEESREVIEKVNGPEGFEDSGMGRIVVLKEGTELGELVKRVKAHLGMKKLMVADGTAGRKIKKLALCAGSGGSMFKNLNVDLFFTGELSHHEALAAKEKGISVISCFHTNTERGFLSAVMKPKLADVLMEEWKKVAETETEGKEGFEVVVSKNDRDPYDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRV4</accession>
    <name>U4LRV4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936481">
        <property type="protein sequence ID" value="CCX34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRV4"/>
    <dbReference type="OrthoDB" id="5496153at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="457" mass="51723" checksum="0A2F6C5329D22ACD" modified="2013-12-11" version="1">MFPRNIDHNRRMGPGNVRRFSLSTELPTNLTLRLSQAMAAADNGPAPNPPNGRGHVRRFSEADEMIYNPPPVDNPPIPPAIPPANNPPRQQIGPGNVRKQSIVQEEPQYHQYPRPTQQELQYNQHPGPNPAEDAPYPNIRTEFTPTPPQLKRYRDVEAWNAAYEDIYGPPPVYTLYQNIPALQTQYNPLYRPEARHPDDVFGPDYSVNPANAAPRQVAQRMIPSQTLPYPMQHDPNYDSGHIVNPRIIVASQTLPVHIQQNSDHDDDCDDDDDDDNRTIYPASNHTVGPSSAAAKHSQIGLAPDNRKNRVNKTNAISPRQAVSNQRMLSSQTLPVYTQRNIEDEDDDMHLLPGLTGLEIGGERHRDDVFRMDDHVNTTNGIFFQVDNSRMMPSQTLPVGTLYNNNRNNIDAWRRGCAEDVDESRYDSDGFLIDSDEEQNRNVANERQGRYDADEILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSC9</accession>
    <name>U4LSC9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSC9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8023" checksum="45DA19A441A3450A" modified="2013-12-11" version="1">MGRLGGQHPLFLFGPPSQQMENLGQRIAAQDDDFGPAATPSFIELTSSGRGVATTIEASEVRMMKNRILDGYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSQ0</accession>
    <name>U4LSQ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Copper-exporting P-type ATPase A acc. no. Q2YWA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSQ0"/>
    <dbReference type="STRING" id="1076935.U4LSQ0"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DVIRVPH"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="11">
        <location>
            <begin position="569"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124351" checksum="FE88FC7BFBCACE0D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTS2</accession>
    <name>U4LTS2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Fluoroacetate dehalogenase acc. no. Q6NAM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTS2"/>
    <dbReference type="STRING" id="1076935.U4LTS2"/>
    <dbReference type="eggNOG" id="ENOG502SBEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RGARICH"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="361" mass="40181" checksum="1C292E4868662B33" modified="2013-12-11" version="1">MSLPPTPPTDASINTSIHTYESTLPYFNGFTNLHIAIDDYTNIFARVRPGTSDVILVMIHGYPQSSWMYRYATKYLPKEFTLFIPDIPGYGFSTINTPTSNIEAYNKLSHARSILHALDYYLNRSPGGSSIGCTSDNPQKIILLGHDRGARITQRIGFNISEFPQFDILGIFLADIVPIVIQFSSLADPIKAVSTFHWAFLAAQQGLPEGMIQAFGGEKWVEYCLGKWGGSGPGAAHGPAETAEKEKIEEGVYVHSMHFKKQSVVEASCADYRAAAHSDAEKEKREWEDGERIQVPTGVVFSEKYLGSRYDVPGVWKEWVAGDKLKTYGLGNGVGHFCFEEAPEMAYGKFNEWVKDVLEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUL6</accession>
    <name>U4LUL6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUL6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="4037" checksum="925653C1D0AC3DC8" modified="2013-12-11" version="1">MDGMHSPPRSSRDLTSKFRLTRQPSMSSSRSRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUT7</accession>
    <name>U4LUT7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUT7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5882" checksum="F1C2518B58E668C2" modified="2013-12-11" version="1">MHRARYRYRSCNLCTTAGSQVPRLQPTRIRRRLNLWTLDFWIQYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX36</accession>
    <name>U4LX36_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX36"/>
    <dbReference type="STRING" id="1076935.U4LX36"/>
    <dbReference type="eggNOG" id="KOG0011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHMLEPI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000175">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000001">
        <property type="entry name" value="UV excision repair protein RAD23 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad23"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
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        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="391" mass="40748" checksum="9704BB68BA1A0FB4" modified="2013-12-11" version="1">MKLTFKDLKQQKFTLDAEPSDTIAQVKEKIFKHKEDSKEWDPSLQKLIYSGKILADDKTVEFYKVEEKGFIVCMLAKPKPAPAAAAPAAAAPPSTPAQTRTVAPPSAPAPAAAAAPAADAVPATPSPAPAVSAAFNDPSALALGPQLNAAISNMMEMGFPRDLITRAMRAAFNNPDRAVEYLMNGIPDHLLQEQAPRAAPAAAAPAAAAPAAAPQPAAAGNQPAAEPENINLFEAAAAAAAGRGNAGARASGAAALAGAGAGAAVQGLEFLRSNPQFQQLRRLVQESPQMLEPILQSVGQGNPQLATLISQNPDAFLSLLAEGADDGDEPGPNEIMVSEEEHAAIERLCQLGFHRNLVIQAYMACDKDEEVAANYLFDHPEDDEDMEGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX93</accession>
    <name>U4LX93_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936511">
        <property type="protein sequence ID" value="CCX34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX93"/>
    <dbReference type="STRING" id="1076935.U4LX93"/>
    <dbReference type="eggNOG" id="ENOG502S6YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="97" mass="11500" checksum="7143569726447C18" modified="2013-12-11" version="1">MLTDRSAHRYPKHVWSPAGGWYSRPANWKANTAVMFAVIFGITAFAFKTSAEREVRYRMPDPDRFFPSRCKFFRPFERWMSEAGGRSRMWEEEKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTT7</accession>
    <name>U4KTT7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ankyrin-1 acc. no. P16157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935201">
        <property type="protein sequence ID" value="CCX04398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4KTT7"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICLEANQ"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="251"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="930"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1309"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1479"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX04398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1557" mass="174501" checksum="19D89F7958F4A4EC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU78</accession>
    <name>U4KU78_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU78"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5641" checksum="DAAC0EE2A90F16DB" modified="2013-12-11" version="1">MFQCVCTAVHLGLGYLTLPGYYVFPGSFHGEILYNTHVGNCQQPPVSPNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUH4</accession>
    <name>U4KUH4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935221">
        <property type="protein sequence ID" value="CCX04943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUH4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="34" mass="4031" checksum="2FBD335322713F8D" modified="2013-12-11" version="1">MVTGTSYQPFARDRAKMIKMMDSNEYLSERCWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV47</accession>
    <name>U4KV47_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 60S ribosomal protein L16 acc. no. Q9P720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV47"/>
    <dbReference type="STRING" id="1076935.U4KV47"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="22649" checksum="8456513ABE96C1A0" modified="2013-12-11" version="1">MSSFEPVVVIDGKGHLLGRLASTVAKQLLNGQKIVVVRCESLNISGEFFRAKLKYHAYLNKATRFNKTHGPFHFRAPSRIFYKAVRGMIAHKTTRGKAAMDRLKVFEGIPPPYDTKKRMVVPQALRVLRLKPGRKYCSVGRLSAEFGWNYGEVVSRLEEKRKTRSEAYYQRKKALVRKLNAAKREVSTNVEELAQFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVH7</accession>
    <name>U4KVH7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Beta-glucan synthesis-associated protein KRE6 acc. no. P32486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_04884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935244">
        <property type="protein sequence ID" value="CCX05297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVH7"/>
    <dbReference type="STRING" id="1076935.U4KVH7"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="343"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX05297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="747" mass="82551" checksum="018C1F87D69E2AAC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVW4</accession>
    <name>U4KVW4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVW4"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="13037" checksum="E15EF429190097D7" modified="2013-12-11" version="1">MALEYFSRAYICIDALDECKESYQAQFLKSISKLLANQSVRVFITGRHVTESKIDNYLFSSESMTTKMKIEANAADFRAFIQDKIDNHDVEEFEMSDAFKKEIIDTIIASANGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWA1</accession>
    <name>U4KWA1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935252">
        <property type="protein sequence ID" value="CCX05371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWA1"/>
    <dbReference type="OMA" id="CPDINED"/>
    <dbReference type="OrthoDB" id="10639210at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="471" mass="52958" checksum="8EF301C976D2F7C6" modified="2013-12-11" version="1">MPPKMIPQVVIYRASPKAALDPLVSLHKYLISHLSILPLLATITSFLPLLLFLIRFHRSTASFQAIMPSLPCPDINEDEPVYTCKRPKCQRRGNRNFFLNKSTNMLTATCGFCRRSTRSEWDHLRVEKPEPKSIRKRATKSKTKQPEQQPEASDDHDNADDEEVEPAETNSKTPSKKAAKKVKKSEEKVDDASDSADEQLLRESAASAEKKKKTSLKPKASMAPKTPKTPKTPKTPKASRSFTAINAKFVEKPEEEEEEEEEEEEEEEEEEEEEEESQEAEEAEEAEQAQAKEAEQARAREAYEAHQALINEAHQGLLDCAPHFYRRASPPRARAGTLDSPGSPGSPGSSTGSTGSSANQKKRRTPTSPHSPEPSQIAKKLRSSDAEEEEPVKYQRRKRIGLASAGYVNTSDRAVMTKMPEKVKKEEPKNEEEQEEEEEEVKEKKVTASKQKGKATQKKKAPQKRKSRAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWG1</accession>
    <name>U4KWG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWG1"/>
    <dbReference type="STRING" id="1076935.U4KWG1"/>
    <dbReference type="eggNOG" id="ENOG502S22Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGEHIEW"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="337" mass="36547" checksum="7DCE6317D31B15FB" modified="2013-12-11" version="1">MSTSSDRKVEEAGHISHVQLTRGQRVKAHFRKWWWAHLINFCVFVVVVMIVAVYGIIPPVAQKLIDKTTLSINAFSITSPTGTSFKLGMDGTIKGATGPADHAVIDSFPVKLFLDDVRVNGDIRPILEFPVPKAHGGGDIHVLQNDIPISITDEGALDQYASRLMDSVEMRVGLRGRTTIHLGAIHTDVNYNEVVQLKGLNKLTGMVITKYTLHTNNSEGNVGGDVLIPNPTVTTIEMGDVGLKISYKGAAMGTGVIKNLILKPGNHTYGFMSHITPDDNILKLATVAIQKDSLTIGSNGTSINGVKIPWLSKPLETMESTVPINTDYFKEKGISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWM3</accession>
    <name>U4KWM3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWM3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5095" checksum="A3B17E570E0F8ABC" modified="2013-12-11" version="1">MILRRVACLDSSGYPQTSKPCEGATCFSLTHTPASEVQGSGFASLKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWW9</accession>
    <name>U4KWW9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_06044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWW9"/>
    <dbReference type="STRING" id="1076935.U4KWW9"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="14">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="414"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="13">
        <location>
            <begin position="415"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX06457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128531" checksum="249D2666E0705C26" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXA2</accession>
    <name>U4KXA2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXA2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="201" mass="22820" checksum="6216178C8A03252A" modified="2013-12-11" version="1">MADDHNATATCSASDITVYSTSTNGYWSPTEKFDDLDSRIYCFARTEYDKNSMPMITFGFSSVNLSSTRRSKVTPHQFTISVTFKDLHHCVLLYESKQLMVTARSLTFLQKPSYIGNTFPPFRDSVINIIGDEKAMYGKVVFQANVEDTKFLSHVTRDIALQFVLGAETITKRWRICSHISTRAQIAYYNANATLPTLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXH6</accession>
    <name>U4KXH6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Probable 20S rRNA accumulation protein 4 acc. no. P87156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXH6"/>
    <dbReference type="STRING" id="1076935.U4KXH6"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HQVIRYS"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="451" mass="49074" checksum="7F622B96777EC373" modified="2013-12-11" version="1">MLQELIFMLAGHLTSIFTSLYRDLDNWINNEVTNQQRRKEEIYNKMDSDEDIQDYTETTVLLGYAEEDPVGNDTASHLGGAPTWLAPTSPADARLAKCTCCNNLMTLLLQLDGNLKDYPHERMFYVFSCPSKTCRRKPGSVKALRAVKVSKDWEERQKKDAEEKAKKEAEKKAAAAAAPRTGDMLFGGGGFGGGMGGANPFATAGAPANPFSTGGASANPFAAKPAAPAPAPAAPTPVKTLEKTFAESLNISKPAEAAPEPLLYGPVEPWPTPLPHQYPNFYLDADYETLAPEEKIDVPKIQEIIEEADNAGDAPVSSSDADDGVLDTTFQKFADRVGQNPEQVLRYERGGQPLLYSDSDEVAKLLLEKGGKECSMKRVPACKGCGKRDRQFEFQLMPHAIAVLEGDSMSLEGMEWGTIIVGTCNCTPKARDGNGVGWCEEWVGVQWEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ33</accession>
    <name>U4KZ33_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ33"/>
    <dbReference type="STRING" id="1076935.U4KZ33"/>
    <dbReference type="eggNOG" id="ENOG502RZYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WTWFNLE"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651524" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29325" checksum="C3FD83DAD6CECACA" modified="2013-12-11" version="1">MKSITLLSFGLTLLGVASAHMKMIEPPSINSEEGNYDVSIRDYNQMANILPDGSNFPCRGHHLSTADMIPRRTYIAGQQYSFKVVDSPDAPEAGQGNHGGGSCQFSLSYDNGKTFKVIKSIMGGCTAVDRNLQNQEEALGPKGFPAWVNHFTIPASAPAANNVIFSWSWISFNGIQEFYQNCARVEIQNPAPQGDFYSLPNMFIANIAHDGLPRQCVPKLDTGKSWVVYPEPGNVIEYGFNRVDRHTEQPYADGDIKTTAAAVLGQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L098</accession>
    <name>U4L098_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF935384">
        <property type="protein sequence ID" value="CCX07974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L098"/>
    <dbReference type="STRING" id="1076935.U4L098"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEVDWWS"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF422">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX07974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="543" mass="60433" checksum="5B80F78C730D7B49" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0F4</accession>
    <name>U4L0F4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Type 2A phosphatase activator TIP41 acc. no. Q12199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935363">
        <property type="protein sequence ID" value="CCX07688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0F4"/>
    <dbReference type="STRING" id="1076935.U4L0F4"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FESESWQ"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="361" mass="39671" checksum="7D9D5173C0807C14" modified="2013-12-11" version="1">MSGNPPLRNPMEDTRAPFATTTAPGAAGAPTRAPFAATAPGASTFNATTRAPFAAGAPTQAPFAATRAPFTTTIRSSAPVSSLPPMFATPAPSRNAGKSLSHLGWEISTTKLPICAAPEIDAMTVSLGIAPPEMIFGNNLISLYHQASGWGIKFNSYDALDLVDKTGETMLKVAYSEEWGRSRKEMVDGEKESELGGKVRDVAKKWDWSYSTEYKGTMVGGEGVPKWEKGGELPLELLKRPDPILLFDEVVLYEDELADNGIAILSVKLRVMPERLLLLQRFFLRLDGVVVRVRDTRVYVEFKTGEVIREYVNKEMGYGKLREEFKMYPADEIPSLMRDPNQLVDVMPVIETIRERLVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0R2</accession>
    <name>U4L0R2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_05221</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="HF935262">
        <property type="protein sequence ID" value="CCX05634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0R2"/>
    <dbReference type="STRING" id="1076935.U4L0R2"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="63"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX05634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="32939" checksum="52A962DC015101BF" modified="2013-12-11" version="1">MAPKNNANLLSTPLHGLYIPAGLLVLGAAIIDRNYIPHAIGLAIILGALKVLRAKPTRVLKADEFQEFTLSDKTIISHNVAIYKFDLPSPTSILGLPIGQHVSIAATIDGKEVVRSYTPVSSDADLGHFNLLVKSYPTGNISKHLADLKIGQTVRCRGPKGQFVYTPNMVRAFAMIAGGTGITPMLQIIRAITENPEDKTEVDLIFANVNQEDILLKEDLDEIAANNSNVRVHYVLNNPPEGWTGGVGFVTADMIKDWCPAPAKDVKALICGPPPMVSAMKKATTALGFEPAKPVSKLEHQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L107</accession>
    <name>U4L107_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L107"/>
    <dbReference type="eggNOG" id="ENOG502SCD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KVFHCVV"/>
    <dbReference type="OrthoDB" id="5361617at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="66"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="415" mass="45505" checksum="64F48D943009DFE7" modified="2013-12-11" version="1">MPPNTTTTSSTSPQTAPKPPPKPAGLPNLGEKLAIALLEHKVKALEEEANSITNRRPPIKKIYYCVCDETVLTEDIAGLQRRIDAKSIHVIVPFTTLNALDKLKKGADARSQMARRSIHYFDRVMQSTVKGGVTIQAPNLKYGTWAECLAAAPISAGESAPIAGMASLALRSSYSSSDDDYEPTNSMKDILNCAVHRLNDEKLKQVGNVILVTNDRNEDRDDPDMHLYEWAKSFGIPTYTTTELSKLVPLEREKNGRGRGGAEPQRTEAPAEPVQIIDPNSFSRGGNTSPRAERTQRKEIFPIGNESSRREGSRRSDGFSRGGGMPRGILFRANSSPRDATSPRTDVFRSPNILTRADSYNHRESIPRGDNNRNNYSPRGESFSPRADSFSHGAPTTRGGHTGGVARGKGKLWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1H0</accession>
    <name>U4L1H0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized MFS-type transporter C530.15c acc. no. O74829</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935493">
        <property type="protein sequence ID" value="CCX09702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1H0"/>
    <dbReference type="STRING" id="1076935.U4L1H0"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQETHRD"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX09702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="508" mass="55513" checksum="C11053FDF20C9B90" modified="2013-12-11" version="1">MPDNLRADVEKTVATHGDSKSTTRASSEIGRDNEVTPLPSTAPLDWDSPYDLDNPWNWPMSKRWLGTIVPGALCLLVLTGYHNISTFTASVYAASVYQVSREFHVSITTALLGLSMYVIGLGLGPMFSAPLSEVFGRKMVYFINLPIFLLFTLGAGLAKNIQTLIICRAFAGIFGGPALAVSAGSFVDIWDLKTSGSAVTVQAFATFMGPALGPVVGGYLVQNHGWRWSMYIVLLLGGFLLLPLSLLQESYKPVILTRRALSRGQNLPPKPDPKTALKMIFTITLARPTVMLIKEPIVQAVALYSSFAFAVLFGFFEAYPFVFQRDYKMNLGETGLCFLGIAAGLCAGCGIYLLQDRLCYVPAHKKHNGHPPPEVRMVPAMIGSLLMPVGLFWFAWTAERGVHWVVPIVAGVPFGAGLVLVFLSAVMYILEIYSPLVAASAIASLGLLRYLLAFAFPLFTIRMFEKLGVKWAASIFGFLAVAMMPIPWVFTKWGAKIRGWSRFDAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1R4</accession>
    <name>U4L1R4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935468">
        <property type="protein sequence ID" value="CCX09520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1R4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="16815" checksum="5260DDB801BE753A" modified="2013-12-11" version="1">MAAWPTGPSIPHLRPTCLLPVSYPTAQTTPRSEPALGSFSLLACTRFLATVVCNPDPRSSRAVGYHSNATPPRFPDLVFGSWLHACTAVQSRRCRVDRPQRRSETDSSAIGLDKDSVQFLRQSQTGHSCPAAQEDVLSSFVVVVVNSNNACSMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L255</accession>
    <name>U4L255_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Demethylmenaquinone methyltransferase acc. no. A6L3D5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935444">
        <property type="protein sequence ID" value="CCX09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L255"/>
    <dbReference type="OMA" id="FEISSHM"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="20990" checksum="8644CD7E38BB47F4" modified="2013-12-11" version="1">MHHEIMLEMLDGKLHLAPINQNPERILDVGTGTGIWAVDCAALYPSAEMIGTDLSPIQPSWIPHNVTFEVDDAARDWTRPDNYFEFIHIRNISQGIEDWDQLLGEAYRCTKPSGYLELAELEMKLYSDDNTMAPAFNKWIQLLKDASDKMKRPSVSGVNQTASRKRRFCGCQRRYGEATIWTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2B4</accession>
    <name>U4L2B4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Probable Ras-related protein Rab7 acc. no. Q9C2L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935501">
        <property type="protein sequence ID" value="CCX09974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2B4"/>
    <dbReference type="STRING" id="1076935.U4L2B4"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX09974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="218" mass="24516" checksum="BBBF07E13105722D" modified="2013-12-11" version="1">MRRQDKVCNTYWPELPELVGKTRQIIILGDSGVGKTSLMNRYVNKDFSASYKATIGADFLTKEVILDDRSVTLTIWDTAGQERFQSLGVAFYRGADCCVLVYDVNNAKSFENINSWREEFLIQASPRDPSSFPFVCVANKTDLGENKRQVNRTLAKNYCDQQGQLPYFECSAKNGNDVEKAFEVIARHALAQQESEMGDILEDPFLPAIIEDRGGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2X3</accession>
    <name>U4L2X3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2X3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19689" checksum="87BF7AA945492C95" modified="2013-12-11" version="1">MYESKPTCNPEEIGVLRDKMVSSDEVPEIPNLKEIQHVMDGSSGIVHRGGKGNERQKGHSFPKTTFIRVCRKDLIDTKGKFEKFRGYVLGRTRMFYNSDLEFDHPDFETRRINDVYHCVLLPHVIVRLRVERAAERLARYEFGSEQVLKSTGVPGSMTRSSETEIRHMAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L326</accession>
    <name>U4L326_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935304">
        <property type="protein sequence ID" value="CCX06658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L326"/>
    <dbReference type="OrthoDB" id="10374161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="485" mass="53634" checksum="CA970B4BFE7886C0" modified="2013-12-11" version="1">MPDEHFLDAFSAPSLPIFLTPASPTKTDISTTSEPTDPIDPTKLIVPGEVTAEDLRYIKALRAEAISPVKRLIQRMASEESLQAPPASGPLPLSCCPLEISPLLGILNNFDLLFDLTIEARQNILNEILLSTPSHGIRITQQAPEHIKPADWKELIYRYECCLMDSSITVELHMQIAEMMGNNNTIIPFPKTPAGAKTPLETFSEKVRAQLGTLRGGFKIKCPKCGKKKQPLWDPNIFKGMELVDEDGTVIGDIDENGELGLFVSDDMDEFMIIELKKMIAAKANEKIEKNAIAAGCKPLSVPKPKTAADVLTKIWKATADKTFKNADAMQDQLEAYGKQKKKEQVRILTDILKPNTYGYNTETSLDQINANMDAAISAANDILVREDAGAIILDMPAEMKEGARKYLNRPEREMVKKAMDNFSGDVKGMIDDLKEMGITKDLTLGEITKQLHDKHIKCLKPDALKPNIPKPNVPKPSAPKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L377</accession>
    <name>U4L377_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_10516</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L377"/>
    <dbReference type="STRING" id="1076935.U4L377"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX10922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="450" mass="49137" checksum="099846B43D875157" modified="2013-12-11" version="1">MLSRLMLKGIKPMTQVRTLATVVGKAANKRATFTIRFQDGPIHQGISFGANKTISGEAVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSNVRDESGLYKYFESPNIQAAGIVVSDHAEKYSHWTAVESLGDWCKREGVPAISGVDTRSIVTYLREQGSSLARITVGDEYDADQDEAFIDPEQINLVAKVSTKQPFHVASTGDLHVAVMDCGVKENILRSLVSRGASVTVFPWDYPIHKVAHHFDGVFISNGPGDPTHCQKTVFHLQKLMDSYTGPIMGICLGHQLLALAAGAKTVKLKYGNRAHNIPALDLTTGRCHITSQNHGYAVDIKTVPSDWKEYFINLNDGSNEGMIHKTRPIMSTQFHPEAKGGPLDSSFLFDSYMEQCIKFKAEQGGLIPARLGRPNPLLVDLLAKERVGVTPDHVLAAQGQTAAEEVQMEEIAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L380</accession>
    <name>U4L380_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935501">
        <property type="protein sequence ID" value="CCX09983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L380"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="5422" checksum="FA05E44651171932" modified="2013-12-11" version="1">MLLFSRSCWIVVCSSASQRRIRTESLRELMMIFGAFIYPWRPNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Y2</accession>
    <name>U4L3Y2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Major centromere autoantigen B acc. no. P07199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935540">
        <property type="protein sequence ID" value="CCX10409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Y2"/>
    <dbReference type="STRING" id="1076935.U4L3Y2"/>
    <dbReference type="eggNOG" id="ENOG502QQS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="674" mass="74962" checksum="91CB5E932E453DC2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L474</accession>
    <name>U4L474_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L474"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5618" checksum="DD7D8333C966AFB1" modified="2013-12-11" version="1">MTLLIQSPILVLYSCSLLSLAALSLFCALARKLGLHIENQIPKSRTAVKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4N9</accession>
    <name>U4L4N9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_10419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935567">
        <property type="protein sequence ID" value="CCX10825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4N9"/>
    <dbReference type="STRING" id="1076935.U4L4N9"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIFGFDP"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX10825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20875" checksum="CC6C37EA7FFE23CE" modified="2013-12-11" version="1">MFARTATRVVTAAPKPVSTIQTVVRHASSTPAGKQETLDWDSFLKLRRLRRRYNLASSIFTSFVGTSIGIGYLANKEIDVTQTILGMDPLIMFGLATVGCGAAGWLVGPSVGGAAFNIAKKRWISQIAEREREFLKHIQKNRVDPSFQSFSNPVPDYYGEKIGSVKQYRQWLKDQRAYNKKREAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5B5</accession>
    <name>U4L5B5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to 3-dehydroshikimate dehydratase acc. no. P07046</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935661">
        <property type="protein sequence ID" value="CCX11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5B5"/>
    <dbReference type="STRING" id="1076935.U4L5B5"/>
    <dbReference type="eggNOG" id="ENOG502QW0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SNAWRPL"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="30"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="334" mass="37621" checksum="165C7FE67F7B10F8" modified="2013-12-11" version="1">MPTEVDHIPLSYATPSLGMHPSHTLEHKLSAISAAGFMGIELGFDDLLSFARRYLHNPTISATSYDQLCIAAQKVRLLCAPNNNDLTILVLQPFSNFEGYTGEKRKEAFERAAGWKRILEALGCDMLQVGSNDDAESSSDYATIAKDLKELADLMAPKKIAYENWCWGAHVNTWAHVNDICKRVNQDNFGLCLDTFQTAGGEWGDPTTASGLVEGVEEERENKWFDSMRQLAITVPAEKIFVFQISDAFKPEKPLKNRSEWSHGYRPNPYCGGYLPVEDMVRAVLKTGFRGWFSVEVFNEKEHRKEWREGLEEGWAKEGMESARKLLKECSGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6G1</accession>
    <name>U4L6G1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Rhamnogalacturonan acetylesterase acc. no. Q00017</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_07605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6G1"/>
    <dbReference type="STRING" id="1076935.U4L6G1"/>
    <dbReference type="eggNOG" id="ENOG502S0HX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIEMGHN"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651703" evidence="3">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="274" mass="29947" checksum="E7A22CAAD840B1C8" modified="2013-12-11" version="1">MSFSFLARVVFVLQLALAVYGNPTRTTRLPSLYLCSDSTASNYDPQTTVIQGFGYYLHDYLSIPVHNLARAGRSTRSFQNQGLWAQLLAMVVPGDFVVIEMGHNDNGTPGTGGDVGKDRAVLPGVGEETIVVQNTTGGTGSETVYTFGHYLRGMIKDVRKRGGIPVLSGMVPTMAWTNGTLQTSWPFTEWARQTAESERTGFIDHTEYSVEMFQGLGETKSLTMFPEDHTHTNAAGATVNTESFVTGIKCGRSLQTGGLSMFINHKGRTIKWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L732</accession>
    <name>U4L732_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L732"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="55" mass="6429" checksum="A789174E9B977C28" modified="2013-12-11" version="1">MFVTCFSKFKMHASVPILIPCTRDDLIPKLSFVSKKEKPYEDLVTSFNRFCILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L770</accession>
    <name>U4L770_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935805">
        <property type="protein sequence ID" value="CCX13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L770"/>
    <dbReference type="STRING" id="1076935.U4L770"/>
    <dbReference type="eggNOG" id="ENOG502S3V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NINHRSC"/>
    <dbReference type="OrthoDB" id="21072at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="379" mass="41819" checksum="9F0C9A3DCA9C8399" modified="2013-12-11" version="1">MPQPPSPRQLSSRGASSAGNAPQNRPQILKERENSRRTTAGFVATRQLPEVQYTVYVRLPFNRNGFIDPPRVDWDTSKDQYVKQMLPTVMQFKEQDWDTLAAHLQVSRAFLLQEVAWQLENNLSSVRAQMTKTGTGTPVINTNNLPPPPSSGPVSPATPMTNTPRVTVPQPRLTSALSMRSATTPTPRGSPAPQQFLSNRRVPTDPLSTNAPRPVSRHSTEPLNTNRYTPNEPTISSSSRPHRFSNPIPTETDTNESAPPSECSTATSSEDEDDDQSHGRLIRRLPMFLKKQSSQSEDEEEPAFLPFSGTGTVTLPRPDALRRRVIDSAGPSSPSMGSSFSDLSDRCKRNPVNNGGGISEYDAGWRDRKPNINHRSCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L834</accession>
    <name>U4L834_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 10">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_13894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L834"/>
    <dbReference type="STRING" id="1076935.U4L834"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWVFDIH"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX14301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="215" mass="24045" checksum="4FC5EAD3C93AB283" modified="2013-12-11" version="1">MACEKTILDDLLCRNHEWAQRTAETNPALFPALAVGQSPKILWFGCSDSRVPETTVLDLMPGEVFVHRNIANILPSTDLSSLSVLQYAVEVLQVQHIIVCGHYACGGVNAALGQKKLGLIDSWLRNVREVRAKYEKELEGLSQKEQSKKLVEFNVIEQVRSVLKNANVQEAIEERGLEVHGWVYDVGCGECHVLQCPEDPEAHVFMVKNPRAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8K7</accession>
    <name>U4L8K7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8K7"/>
    <dbReference type="STRING" id="1076935.U4L8K7"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX14240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="205" mass="22656" checksum="F3F2F9E8E669D2EB" modified="2013-12-11" version="1">MSNPFSMNGGAVVAMVGKDCVAIGCDLRLGMQALTVSNNFPKIFSYGDAYLGLTGLATDVTTMSELFRYKVNMYRLREERDIEPETMANLVSSTLYERRFGPYFVSPVIAGINQRTGKPFICGFDSIGCIDFAKDFIVSGTASDQLFGTCESLWEPDLEPEDLFETCAQALLNAVDRDALSGWGAHVYVITKDKIIKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8T8</accession>
    <name>U4L8T8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935793">
        <property type="protein sequence ID" value="CCX13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8T8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="20922" checksum="F89A8DB630FD3AE3" modified="2013-12-11" version="1">MVYAYPDEEDILYEKPLGMPARHRAGSISLPGIMAQKPQDFSINDIQVPLLDREMPVRDELRGPLKPAEAWYKKQLILIRVEDRLPVDVAGEEGIRGRKEEELKELQQYLQHKYRLDLKELKGRFELPQEVKKGLRPIVNKAQAQVVVSKVMVEREVKDKGKAVDGGRGNIKDGGDEKKRANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L946</accession>
    <name>U4L946_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized WD repeat-containing protein C25H1.08c acc. no. O13982</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935509">
        <property type="protein sequence ID" value="CCX10091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L946"/>
    <dbReference type="STRING" id="1076935.U4L946"/>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPDEVMW"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX10091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="446" mass="46577" checksum="BA38C32681AD48C4" modified="2013-12-11" version="1">MSASNQPAPIDIESDNELDLADVDEIVADDGDVPMSDDEGDAEEDMDTDELAITNDSRAYFDGHSSSIFSIAQHPTQPLFLTGGGDDVAYIWTSAAASAEDAAVVPRELRQIRKLEAHKDSVIATCFTAPDGAYAVTGGLDGMVQLFSAASGWKKVDGAQEVEEVVWMAAHPSEPVIAVGTNEGSVWLYDIDSDKLVIRHVLYSHTASCTAGVWTKSGNFLCTVSEDGSFYAWDVATGQSVVALTADDQRFNIDGGLYSVACSPSGAVAAVGGATGEIRVVGLPTTTDGGKRTAGRPMASGGGSTGGGQAGQIIASIKAHEESVESLAFHPSTPLLASGSVDGKIALYDAQRGYAIRKILEGHNDTVVKVEFVSGLTVNEPWLLTSCGIDGTLRRWDARSGEELKCLKGHLGGNGDDGEGGILGFVQTKKEIITAGDDAVALIFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9F0</accession>
    <name>U4L9F0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9F0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="7990" checksum="7778E8B388068152" modified="2013-12-11" version="1">MHVVGASAQAALPSFSVLSSFGSIKIRFTGSPWGKLPSFLHLFQCSFVGVLGKKGSIVFLGHLVSYLEDHNRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAM8</accession>
    <name>U4LAM8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Superoxide-generating NADPH oxidase heavy chain subunit A acc. no. Q9XYS3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_03126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAM8"/>
    <dbReference type="STRING" id="1076935.U4LAM8"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DENQAIH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="268"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX16483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="578" mass="65994" checksum="2D065BD25C885597" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB53</accession>
    <name>U4LB53_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_10940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1076935.U4LB53"/>
    <dbReference type="eggNOG" id="KOG2125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWNQTGQ"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="429"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="838" mass="92824" checksum="BE6DECC219A796CE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBI1</accession>
    <name>U4LBI1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBI1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="154" mass="17848" checksum="E9681AE342339BD9" modified="2013-12-11" version="1">MWDGRVLVSPPILYLIIFWASHSNFVTRRSYGRTCWWTVVGTQREHGPREFPRLVKVTATPHVGHDLSTRCVQQSHRDPTLESYNGYKILQSNIIVHINILKCKKHRWCSRLWLWLWVCGPRAVMGRVDTTPGSTSQAREGRGWGSFLTRSSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDC1</accession>
    <name>U4LDC1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Probable altered inheritance of mitochondria protein 13, mitochondrial acc. no. Q5ASP0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935423">
        <property type="protein sequence ID" value="CCX08600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDC1"/>
    <dbReference type="eggNOG" id="ENOG502SDJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKSLNCW"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="160" mass="18203" checksum="98436B47D0755D36" modified="2013-12-11" version="1">MGSSNSTPRPIVLSGETPVRFSSSLVETLQSSSETDHTREKALELHIQERVASELRRLEARESEILASVDRKLDKQIASEDGLNREKVQREIDALKARLENVPKVLELEEGVKNARENVVSCLRANSTRPLDCWKEVAEFKEQTRRLEKAFVVKTVGREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDE5</accession>
    <name>U4LDE5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_12161</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDE5"/>
    <dbReference type="STRING" id="1076935.U4LDE5"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNIAKDS"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="189"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="409" mass="44804" checksum="D04A3B4629A9C0C1" modified="2013-12-11" version="1">MSENDTTMPEAARSPADNDEPTVTDAMPTETNAVATTTENGAEETAVATTDGKKMIKKKKRRPARAQVDPETFKGGEIPEQTGTVFNIWYNKWSGGDREDKYISKAHASGRCNIAKDSGYTKADKIPGSYFCLFFARGLCPRGADCEYLHRLPTVHDLFNPNVDAFGRDKFSDYRDDMGGVGSFMRQNHTLYVGRIHVSDDIEEVVARHFAEWGQVERIRVLNSRGVGFVTYVNEANAQFAKEAMAHQSLDHNEILNVRWATQDPNPVAQARDKRRVEEQAAAAIRAALPAEFVAELEGKDRGAAKKRRIEGSFGLAGYEVPEEVWYARGENAVNPAGRIGGAEEQRMLEAPSAQQHPQEEEKAGGIFSSSALSALKGLREGGGARVITKKEEPAGGMGLALDYGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDG1</accession>
    <name>U4LDG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Protein transport protein SEC61 subunit alpha acc. no. Q870W0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_05638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDG1"/>
    <dbReference type="STRING" id="1076935.U4LDG1"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="475" mass="51929" checksum="5C1458A6E79BA504" modified="2013-12-11" version="1">MSGLRFLDTIKPFVPYLPEVAAPERKVPFQQRMMWTGLTLVIFLVMSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGISPIISSGMVFQLLAGTHLIDVNLDLKSDRELYQTAQKLFAIILSLGQATVYVLTGLYGQPSDLGAGVCLLLVLQLVVAGLIVILLDELLQKGYGLGSGISLFIATNICESIIWKAFSPTTINTGRGPEFEGAVIALFHLLLTWDNKGRALKEAFYRQNLPNIMNLLATLVVFASVIYLQGFRVEIPVKSSKYRGTRGTYPVRLFYTSNMPIMLQSALSSNVFLVSQMLYSRFPDNLLVRLLGVWEPKEGSAQLFANSGLAYYMSPPLNFTDALVDPLHTAIYIVFMLGACAIFSKTWIEVSGSSPRDVAKQLKEQGLVMAGHREQSMYKELKRVIPTAAAFGGACIGALSVASDLMGALGSGTGILLAVTIIYGYFEMAAKEGELSGAGQFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDH0</accession>
    <name>U4LDH0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDH0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="19269" checksum="3F227CD9CE2CBFA1" modified="2013-12-11" version="1">MAFWEGPDGKIYTTNFEGGPLANRGMVEVQSEHGPAALEAMIARHHGVVRPGRDDGPAAVGRFRLTADGYYELVSAPQGPPGRLDPPAGAFPAVIPVPQGPPPGFIHPRLLGIEPLPAALPPVQAAPNWLPQFLPGQHLPLNAAQFIPGFFPQPAAPVAAAPAMPGRMYGEKPWVGPRLPNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDI0</accession>
    <name>U4LDI0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="23703" checksum="1B14218A2E30BCD6" modified="2013-12-11" version="1">MALYGLRIPPAPKYNGSETPDTSATIALIPQTDTIKRDGTESEPKSEEGMRVLLFGFIPITRFCRVKHGRRLSPRDWIIQKVMAYDISKGQRKSYKHSTEAQHNPDVFEVEASTFRGPTRAINQTPTTIEEFMDNSRYSVARISRASGRRWETPNTIDAYIDNARRTNPSRWETPNTIEGYVDNARRIGSYEFRGDSLFLSSSGTGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDN2</accession>
    <name>U4LDN2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to eukaryotic aspartyl protease [Glomerella graminicola M1.001] acc. no. EFQ27702</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08513</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935437">
        <property type="protein sequence ID" value="CCX08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14419" checksum="40229EFB573A52D2" modified="2013-12-11" version="1">MHRCTSFGNGGNWPTFKIHIDNATASGQTMWILPGTDLSETWVVSQNACNTSTIFCRSQRWGDFNLTRSKSWENIAPYVMEANPIYFNLSDPLWADIPSFAPRGDYAAATLGLTDGSDSLTLPHQIVANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE00</accession>
    <name>U4LE00_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE00"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="46" mass="4903" checksum="044A090B67B7169C" modified="2013-12-11" version="1">MHKTSLVVSLVRTKLHLGKTSEILASSLWISLGLLVDGTASCVTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE20</accession>
    <name>U4LE20_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Lysine-specific demethylase 4D acc. no. Q6B0I6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935457">
        <property type="protein sequence ID" value="CCX09334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE20"/>
    <dbReference type="STRING" id="1076935.U4LE20"/>
    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032452">
        <property type="term" value="F:histone demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="JmjN" evidence="2">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="296"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX09334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="526" mass="59429" checksum="A44E28C9051D50EA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE62</accession>
    <name>U4LE62_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase acc. no. Q9RPT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE62"/>
    <dbReference type="STRING" id="1076935.U4LE62"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPNGIHL"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="298" mass="31352" checksum="BAC5ED02C1156B36" modified="2013-12-11" version="1">MSDVDSSNPLLAQHLFTTPSFKAVVTGGGTGIGLMITQALAANGATVYITGRRSSVLETTASTYEGKIIPMTADHRSQDSIQALVKEISQKEPNGIHLLVNNAGVAEEQSTTAFSTDKDLDFTNAEAVSEHLKKSRPEDWQKTMETNVAAVYFTAVNFIPLLAKGTANTRGYSSSIVNICSISGVMKTSSSGQFAYAASKAAALQLTRNLATTLKECKIRVNAIAPGVFPSEMTAGGSDERNKSELKGMGDSLPAGRTGRDEDMAAAILYLVGRGGLLLNGQVLYPDGGNLLTQPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF86</accession>
    <name>U4LF86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF86"/>
    <dbReference type="eggNOG" id="ENOG502SEQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGNRGRM"/>
    <dbReference type="OrthoDB" id="5230947at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="7877" checksum="84D146EF118AE6A3" modified="2013-12-11" version="1">MGAVVSCIKSVFRAIGRALTAIVNGIAGILMAIINGIANVFNIIISCLTCGRAGSRRHSMRTRGTGRGFRSSRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF90</accession>
    <name>U4LF90_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein mesA acc. no. Q5BGR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF90"/>
    <dbReference type="STRING" id="1076935.U4LF90"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRHFWAQ"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="49"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="702" mass="78009" checksum="7055B6DEC68724E4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFL0</accession>
    <name>U4LFL0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to DnaJ-related protein spj1 acc. no. O94625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_09022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFL0"/>
    <dbReference type="STRING" id="1076935.U4LFL0"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651967" evidence="7">
        <location>
            <begin position="21"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="145"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="402" mass="45244" checksum="25952C1388B9929D" modified="2013-12-11" version="1">MKFLFRSLLILLSIIPLILAAQDYYKILGLDKSASPKDIKRAYRTLSKKWHPDKNPDNPAASDKFREVAEAYETLSDDEQRKIYDRYGAEGLKKHQQGGQGGGHHDPFDLFSRFFGGGGHFHGGQRRGPNMELNMPISLHDFYTGGQREFQIEKQQICEHCEGSGSADGHTETCAECSGRGVKLVKHMLAPGIFQQMQTICNKCNGQGHVISKPCKICGGAKVKKDTVTLKLDLEKGTPNHAQMVFENEGDESPDWVAGDVLINVIQMEATGEVDPTNDEEVKHGKTDGMFFRRKGNDLYWKEVLGLREALLGDWTRNLTHLDGHVVKLGKKKGITVQPNFVERIKGEGMPIYQKDGEFGDLVVEYEVILPDLMDSGMRKDLQEVFDKWHKKKGEKLVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFP0</accession>
    <name>U4LFP0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to High-affinity glucose transporter HXT2 acc. no. P23585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_08529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFP0"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESHSAQW"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="547" mass="59070" checksum="E5C8D591482340C0" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGP8</accession>
    <name>U4LGP8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGP8"/>
    <dbReference type="STRING" id="1076935.U4LGP8"/>
    <dbReference type="eggNOG" id="ENOG502SHYC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GDYRHSE"/>
    <dbReference type="OrthoDB" id="5420895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="173"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="661" mass="75853" checksum="6D23D25D295584A6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGR6</accession>
    <name>U4LGR6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to PREDICTED: uncharacterized protein LOC100803756 [Glycine max] acc. no. XP_003518029</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGR6"/>
    <dbReference type="STRING" id="1076935.U4LGR6"/>
    <dbReference type="eggNOG" id="KOG4585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2430314at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17703" checksum="77E5119E6FF6B238" modified="2013-12-11" version="1">MDDKFGIFRPDILLQIAPVAALSLETSRRMYDSDRTGHMFVQKLIDRHPGQFHQIMRIDKRSFLLLSDYLETKGLVKQTWKGITVKEQITIFLFIVGQPASVSLMEETFQHSGESIGRYFNSPLDALAAVNKELITDPPDVCLENSFTKIPGSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGZ0</accession>
    <name>U4LGZ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGZ0"/>
    <dbReference type="STRING" id="1076935.U4LGZ0"/>
    <dbReference type="eggNOG" id="ENOG502SA5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422320at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="204" mass="22482" checksum="341EAF1C4EC193BC" modified="2013-12-11" version="1">MQIPTVTPEDLAAFHHRHLCPTSSATCPTLCGTNAAGATGDEYYEYYEEEAYEDDGLGYYPDGAKRTLTDVQIAIFRNSEVQELLKAKRRAAIAAAAAASRKRRRSRTSPSPSPEEVLSLTESAPAPVSRAEAHKNRLNAALWASKHTWDEFGNPVEVADKPKEFVAEVQVSKKGRKDGNEEGEGEAEGKTFFWPKVIPSEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH25</accession>
    <name>U4LH25_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Cell division control protein 16 acc. no. P36618</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_09205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH25"/>
    <dbReference type="STRING" id="1076935.U4LH25"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHKSEPQ"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="150"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX30802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="401" mass="44924" checksum="40F209ABE24B654D" modified="2013-12-11" version="1">MTSSSHPLPALRRNRRFENSFAPLALPDPVAAPPRLNTTAPQVRNLPQIRNPNAPPRSQKHLRSRSQSQANFDNQHHHPMTPHHMHTNSAGSNMQQRHARKAASTAILSSNNHPATTIESLISKPPASLTEALQDLRYLILDQGVAADADGNSALRIYIWSILLGVRPMRSDDYIELVRRGASSSYSKIRNDTFRTLATDPLFRRRVSESSIIRLLNAFQWKMKDSGEDAQYVQGMNVIAAPFLYAARSEVEAFSLFAVFIQRECPGYVRPTMEGVHCGLKLVDQVLQNVDHKLYSHLKAKLLTAELYAFPSVLTLSACTPPLPEVLKLWDFLLAYGAHLNILCVVAQLLLMRDELLAAAQPMKLLRQFPPLNASMIIKYAVNLVTQIPPDLFDQVVEHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH86</accession>
    <name>U4LH86_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH86"/>
    <dbReference type="OrthoDB" id="10461612at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651572" evidence="1">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="131" mass="13726" checksum="E1494ED4FDCE0D45" modified="2013-12-11" version="1">MRVSTSLLFLSSATAVAGLAAPVPTPTAARTAEELYYDQLQCPNCGFLNWDPSMSNVTNTEPPVSDVTLDVSPSTEAEFQALKEKLKALGLEGQDFNEITTTSDFESGVNNIGIKIVGAALAAVATVAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHA0</accession>
    <name>U4LHA0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935561">
        <property type="protein sequence ID" value="CCX31278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHA0"/>
    <dbReference type="OrthoDB" id="10404371at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="24174" checksum="9CAFB53CF9ACFB14" modified="2013-12-11" version="1">MEAQYAPRSFNASVGEYEPHNRRRIPAGKLALQPQIPRDAARDTEKYGTPPNTTAPAMRQSPQTKPSAPAKLPPHSRPQFAASVSTFLETVSSTPSKEKAHKQELIEMELRVRELAKKLELASQNLEPMTEGQRRNLRAKLEDMRSDLRKKDRRFDEWMRKQCDYVEEFVRGLTKEELDWVNGERKRIFGIVDMQPGREWLYVRQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHJ1</accession>
    <name>U4LHJ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        </source>
    </evidence>
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        <source>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
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            <dbReference type="EMBL" id="CCX31878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="48" mass="5272" checksum="F06F3DC8EC332E63" modified="2013-12-11" version="1">MINEATNATETNELCMLRPMVPPGICLVIQIQLICIGHYNAGVRLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX17136.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="529" mass="56860" checksum="D343D32EC20639DC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJD5</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <location>
            <begin position="300"/>
            <end position="376"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32204.2"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="536" mass="59048" checksum="AE0F4D870CBB46C2" modified="2014-03-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJR6</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <source>
            <strain evidence="14">CBS 100304</strain>
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    </reference>
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        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
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        <subcellularLocation>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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</entry>
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    <accession>U4LKM7</accession>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="25340" checksum="372AEEA46E2927FF" modified="2013-12-11" version="1">MGNYKDQQKRQEKKKTEQAAQTNGGIAGSCTAEAVKTKTALNEGEKDTVAPVAPVAPVSGSTTTFHGMNPRPTLSADASNEAQRPPNVLAGVGHQASATPPAADTPTATPSNHTLVATANPDTATPTPHRHGRPPGSKNRPKSPPTLGLVLPASGTASATDLDTQTTTAPATPGQQLVPGFSSGPGPAAARPRSQLSPMTQIFALALASIRARESDRQAQAGIVDTSPRVITRRREDDEEEIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKZ8</accession>
    <name>U4LKZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935795">
        <property type="protein sequence ID" value="CCX32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKZ8"/>
    <dbReference type="OrthoDB" id="10362223at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651689" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="189" mass="20779" checksum="AE91DF8812DB6ABE" modified="2013-12-11" version="1">MNPAFLFKLLLPPLTTARLLPDGSSRCLLNDMSHVQVYLGDTYNSNTLRLGGMMYHNHCADLITAPIMGLIMSRPPPTGNEVACDSFEGQLQPFPDSTWVKAYKIVPGTAQYGRFGDKPVCCFFYEKEGCKIGDLLFGGSEHRARGSVVSIPKGDVTRGEKDRTKIRSWKCFRNCGSPADALKAEIANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL34</accession>
    <name>U4LL34_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935799">
        <property type="protein sequence ID" value="CCX32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL34"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="11674" checksum="C32B5B33A749CCEE" modified="2013-12-11" version="1">MLRNTLASGMLDLRPKGASLNSAPPLRCTSSRAATGTPLCLPSPQSGGLRPVVRRAVKTGWVGARRTGLRLAEDEGGLYEMGVWMADVPCETGFVYEHGYQMGRKPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL41</accession>
    <name>U4LL41_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to N-terminal acetyltransferase A complex catalytic subunit ard1 acc. no. Q9UTI3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL41"/>
    <dbReference type="STRING" id="1076935.U4LL41"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RDTLQFK"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="28467" checksum="420B742CD306ABF8" modified="2013-12-11" version="1">MDIRLLRSSDIPHVQQTNITNLPENYFLKYYLYHALSWPQLSYVAVDLSHPPKYPGEPPKIVGYVLAKMEEEPADGIQHGHITSLSVMRTHRRLGLAEKLMRQSQRAMAEAFGAKYVSLHVRVSNKAALHLYRDTLQFKVEKVEPKYYADGEDAYSMKKDLTYLAAEMEESDDEDDGCCGDHDHGHSHGGHDHGHSHSHGDGHDHDHSHGHGHSHAEHAEVDGDVPSEKELKTYKVGRALGVSDLQEVDARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLC4</accession>
    <name>U4LLC4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative xanthine/uracil permease C887.17 acc. no. O94300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLC4"/>
    <dbReference type="STRING" id="1076935.U4LLC4"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="574" mass="61635" checksum="0AA4856FE27C65CC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM01</accession>
    <name>U4LM01_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM01"/>
    <dbReference type="STRING" id="1076935.U4LM01"/>
    <dbReference type="OrthoDB" id="5378430at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="345" mass="39439" checksum="9B50C9B8CA51D9E0" modified="2013-12-11" version="1">MPIDNAQQLAVPMPMKNLDLNMHSSAVDGDSREIEKRTCESSIRRAFAAHYLLFVHLVIYITTFCAILFWLSGKAMRFNDNIVMEGVSFLRTSDILTIITAVLVVIRTVTARRLQFLLHDLIPHAGKVNIQADVMRRVDNGRIHPNWTLVSNVKRDVTKFEPDRWVNETMYLLPYLLHLISTANDVYRPQATNLEGYIKNVVQNAYSAIWVVLDATLNLNPDKYDPGKSTFMSDITFMMRARIKKQRLYAWLALNLLFTISGILHLLLERLSSRPIIVDTAAAALTTDVSRLLADPQIAKLKWRNMSYVTKEDVFGSEKELCSDNRIRLKLERLGDGFGLSRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM47</accession>
    <name>U4LM47_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_08609</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM47"/>
    <dbReference type="STRING" id="1076935.U4LM47"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QDRGDTF"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="261"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="534"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX30410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="722" mass="81205" checksum="8A5676BE991F4F79" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMB6</accession>
    <name>U4LMB6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_14114</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMB6"/>
    <dbReference type="STRING" id="1076935.U4LMB6"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIYKPCK"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="93"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX33083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="428" mass="47484" checksum="D650BCC9516787B2" modified="2013-12-11" version="1">MSAASETNKRKRASAAVETVPSAPTSGSEEDGELSTATPAPQETAQPSTKRARRQQKEQKEVNQVLPEDDLAKLRPKGYPMNPPPTDRPVRVYADGVFDLFHLGHMRQLEQAKKAFPNTFLLVGIPSDTETHKRKGLTVLTDKERAESLRHCKWVDEVIEDAPWIVTPEFLEEHEIDYVAHDDEPYVSAECDDIYKPCKEQGKFMVTQRTEGISTTYIITKIVRDYEKYISRQLSRGASRQELNLSWLKKNEMDIKRHVSELRETIKQNWSTTGRELRDEFKNYWAPSPRPANGRDMYQFGSSSGASNGNGSNGNGSNGNGSNGSNGAGASNRRASQEEGLRSPKINPNWEHLGTPSRPQSPQTEFANGFSLGLIGGVRSWMQNRASRPGSMAASDDNSSDEDVDPKEPKTPSKSKSSSKAASVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LME7</accession>
    <name>U4LME7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936136">
        <property type="protein sequence ID" value="CCX15151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LME7"/>
    <dbReference type="eggNOG" id="ENOG502RUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEILIAC"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="385" mass="43537" checksum="9C7A8A95613A2835" modified="2013-12-11" version="1">MLLPRIPIPSNHSTTGQMPDYHLGHMRQEFFDKAAVALLWTASILSLALILTRLIWRYRRGETYSKDDKWMAIALVPLLLRLVASHISNAYLTANFNHKLYPYSSMTQVEIYRRTIGSIMVLPSRLMYAGVLWAMKASILYWFERYTGMERPYGTMIKIARVAMIVSYLGVVVSTFVDCRPIQLYWQIWPDPGKCVGAKIQLIVMASLNIVTDLYLIAIPLPLVFRARLPLKRKLQLSLLFSLSFLIVIVTITRMSGLLQREISQKSRSLWASIEILIACIVANAPVLNSFFQRVRQQNLSNQHAAGRSKGVTLVQRKARMPVTGQNSFGSLTRNDGLDSVAEPSAIDITSKRFHSRNMSDGGDRPWFVTGLGISVTTSPTTQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMQ0</accession>
    <name>U4LMQ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935459">
        <property type="protein sequence ID" value="CCX30620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMQ0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="12177" checksum="9EEF7A484A4AF66B" modified="2013-12-11" version="1">MFAVHIEIHDVQVKKFKCISDVEKARFRVIDPYDWEETADVKVFPKDRLFLEWLAYAIRDPSKVKPELELRPHGLEIKRLSNGHALILVLRPRTWSSEKNHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMU5</accession>
    <name>U4LMU5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936091">
        <property type="protein sequence ID" value="CCX33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMU5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="62" mass="7015" checksum="07D97578BEFE97BD" modified="2013-12-11" version="1">MQCKAFPAHWTGFLSYIHSEISSSTLLKISATRTRAKSKQNLKHRLPQHPHSAVAPTNNDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMY2</accession>
    <name>U4LMY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMY2"/>
    <dbReference type="STRING" id="1076935.U4LMY2"/>
    <dbReference type="OMA" id="FARIGYF"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12151" checksum="69B7EBADAA9DEC55" modified="2013-12-11" version="1">MVTKPALSLEDAPESPGVLTPTSNISEPSSPTLCNHCTNDPPLDASESSSGEIVKLGDTEVYISKPADNTDARLLLLLTNGVGVHSVNNQMQADHFARIGYFVAMPDLLVLYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LN24</accession>
    <name>U4LN24_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_14012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LN24"/>
    <dbReference type="STRING" id="1076935.U4LN24"/>
    <dbReference type="eggNOG" id="KOG0121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIRRIIM"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="18853" checksum="185A46D5D5866DF5" modified="2013-12-11" version="1">MAAAIRKISTVQNLDAPSSYFEKRDANKRQRVSESVPKDDPLKDAATLYVGNLSFYTTEEQIHELFSKCGEIKRLVMGLDRFSKTPCGFCFVEYYTHLDALDAMKYVGGTKLDERIIRTDLDPGFKEGRQYGRGPNGGQVRDYYREDYDPGRGGYGGREQRIAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP77</accession>
    <name>U4LP77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CBK1 kinase activator protein MOB2 acc. no. P43563</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP77"/>
    <dbReference type="STRING" id="1076935.U4LP77"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTYTWLD"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="308" mass="34485" checksum="72EF55368A5189D2" modified="2013-12-11" version="1">MNSINQMFSRFRRPGNKQPNSPQQSQQQQPLPGPDFNAAAAGQVAPGGAALQPNSPGASRVAAKPLFLCKPFVTSQLVKGSFSTIVVLPKYVDHGEWLALNVFEFFDMLNRFQGVINEFCTPRNCPSMSAGPGLDYTWLDANKKPMRLPAPTYIEYVMLWISNRINDETLFPTKSSGTTTATTATPSANRPGAVAPAGAPGENWVGKEGGFPQVFEQTCRGIYKQMFRVFAHIYHTHFDKILHMSLEAHFNSLFVHFIHFSRTFNMLDQRDVEPLRALIENFEEQGLFKDSSSSRAQQQQQPQQQIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPG7</accession>
    <name>U4LPG7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPG7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651784" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4650" checksum="EA22EC56E617798C" modified="2013-12-11" version="1">MFVVVFFFLLSCVLGSEARSRTEVDDVSLRDAISEVLSQGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPJ5</accession>
    <name>U4LPJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Pheromone alpha factor receptor acc. no. P0CI39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPJ5"/>
    <dbReference type="STRING" id="1076935.U4LPJ5"/>
    <dbReference type="eggNOG" id="ENOG502QTV4">
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    <dbReference type="OrthoDB" id="5402633at2759"/>
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        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
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        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
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    </dbReference>
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        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
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            <end position="244"/>
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            <begin position="380"/>
            <end position="390"/>
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        <source>
            <dbReference type="EMBL" id="CCX33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="390" mass="42727" checksum="EACB5431EB6B4030" modified="2013-12-11" version="1">MDSEPMMDTTTMAPFRNNTQGPINHPLSDLLTQTILLTTRNGTEIPISLQDLSNIQYLAITWSACFAIQIGAATILFCLLPLLSNPSRRRSLPFLCNMITLAIVILRGILHIYYYFSPFTTPYRLFTEEYIGIPMSARIISIASAITTLLLKAMVQFSLIIQLRILFQNREGIKNALTIGTSLLAAVSTGIYVWIVVLSTEVILQEPVGHSSPNSRLTFASKVTFAGSITVFSALLVGKLLVAIKERRALGLKKFGVFKIALVLGLQTMFIPAIFTIVDSFVDLDGLISFTPALAGMFLPLASMWASAKHDSPDTRSAVGLGKVSYESDRSSRGSHGSDRSDEESLPRTAVSPWSPTAIVNSMRPGFLLGRKGSRASSVNEKEEKEKMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPN7</accession>
    <name>U4LPN7_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX34131.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651644" evidence="3">
        <location>
            <begin position="23"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
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        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
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            <end position="151"/>
        </location>
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        <location>
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        <location>
            <begin position="180"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="415" mass="44159" checksum="AD1A1C13B6954A5E" modified="2013-12-11" version="1">MRFTTRYLCLLLALSFFTITYGQLLDGLAGDGDGQVCKSDEQLCTAGKDEFCCPSDKDCGSKKGQCDDKPKPTSKPEPTKDDKKPEPTSTKEEPKPSPSAESKKEDPKPSPTPEPKKEEPATTLKTSSTLSPTPTPAAANPTPPPASPPPADTTASPSNTTPGVAAVPIPTSTRSPSPTQLADSSNATTGKSTAEKIKAFFTPNVIIIIASSVGGAVIIIGALCFCCYRKRKQGRMLLAAYENPDRDPYAPIVVGGKSYGGGKRPVSETREVDFSPSVPPNAHTAPLSDRSPQAQYYDLYSPDSPAFQMTPQQPMSPLDNGDAYNNYQPGPYGAAVGQAYGAASPGYKQYQRPQRHVQEPLPAAFVPTHTRQLTPTGPMSPVSPISPDSPPRPQRGPDVYVPEQLRGAQHNNHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQB4</accession>
    <name>U4LQB4_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Meiotically up-regulated gene 72 protein acc. no. Q9Y7P6</fullName>
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        <name evidence="4" type="ORF">PCON_01764</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936171">
        <property type="protein sequence ID" value="CCX33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQB4"/>
    <dbReference type="STRING" id="1076935.U4LQB4"/>
    <dbReference type="eggNOG" id="ENOG502QT3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IWVGATN"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="547"/>
            <end position="586"/>
        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="786"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
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        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="786" mass="84849" checksum="4A7CE6024D64E1E5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQG4</accession>
    <name>U4LQG4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_02977</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1729" mass="186278" checksum="7A3901FC7336EE6C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTC7</accession>
    <name>U4LTC7_PYROM</name>
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        <submittedName>
            <fullName evidence="10">Similar to Zinc finger protein 207 acc. no. O43670</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">PCON_09083</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="Znf_BED"/>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="510" mass="55576" checksum="C8BE24288A2F905B" modified="2013-12-11" version="1">MTKKKRRQNPEIEDLIARPWCYYCERDFDDLKILIHHQKAKHFKCERCSRRLNTAGGLRVHMEQVHKETLEQVENALPGRESIDLEIFGTEGIPESEVAAHNQRIMAEFAQKEADRRAASGQSNGPKKPKIDISKELDPAEIKRKLEEHKKAMANGGITPVTPGGAMSPGRAQSPGGFEAHGSPQVPPHQVPYGQSPPPQFQQAPYAMPPQQNAFPQPNAYPPANFPPQQAPPNPYPAAPFQQPPFQPAPQPVPFGRGAPQPQFNGYQQPPAGYPPAPYNGPPQQQQQHQPHFQPPARQHQQSSLPQPHQIPGLPPKPNVPGLPPRPAFTNHPGGFGRGNMSGPPPQQQWNPPHQPQHFNAGPPAAAGFGPPYGMPPQGPANQYPQPGGYGQHPPQHQQPQAYPPPQEVSANATPLGQQRIGLVPEPSLAAPAPTEQPALLPLDTTLAPDAPAATPVEPPTPAVKPKREVRHAYPDTDISPEEKRAALPKYGYKGKKGRENTPMATESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTZ6</accession>
    <name>U4LTZ6_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_10357</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTZ6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="35" mass="3978" checksum="A1F40298B2FE9E6C" modified="2013-12-11" version="1">MVRVGNFAVVVVVVTVSGETIMDDEISLWWLKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUA2</accession>
    <name>U4LUA2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_10830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUA2"/>
    <dbReference type="STRING" id="1076935.U4LUA2"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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            <begin position="14"/>
            <end position="33"/>
        </location>
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            <position position="141"/>
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        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
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</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="EMBL" id="CCX34072.1"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <begin position="11"/>
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    </feature>
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    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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        <source>
            <dbReference type="EMBL" id="CCX32266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="58" mass="6749" checksum="2782AED6B0EF84A7" modified="2013-12-11" version="1">MFYKQCFPSKACSWYRCLWPATLERRGTNPSVREFFRQTPSATSIRNVRSISATTDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV97</accession>
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    </protein>
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        <name evidence="2" type="ORF">PCON_12973</name>
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        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="7843" checksum="EF8F1B95E028091B" modified="2013-12-11" version="1">MMHSPSTCPRGCRSAPVAAAAWHQRRISQSTDTSNQNSQSSLPLRIHSRASPQNPQSGASLRSRDMTPRTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVE9</accession>
    <name>U4LVE9_PYROM</name>
    <protein>
        <submittedName>
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    </protein>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVE9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8187" checksum="FE734E4A7A033D99" modified="2013-12-11" version="1">MHNTNVNLKLGNNSAIHITQEGTISLYGNSFTCLFCPSFPVNLLSISQLDVLGVAGFEASNAQTSREGENEARDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVJ8</accession>
    <name>U4LVJ8_PYROM</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_13446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LVJ8"/>
    <dbReference type="OrthoDB" id="10445941at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
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        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
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        <location>
            <begin position="510"/>
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        </location>
    </feature>
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        <location>
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            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="722" mass="81725" checksum="4A4E52F3B74C874D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW52</accession>
    <name>U4LW52_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22402" checksum="80AB5E106148D2B9" modified="2013-12-11" version="1">MAHYASESSSDEECPSPLQHPNPFSNYAMNTTLLGSAIFYNKVHKESVAHGRRRGPIYSKNDIDHHGVSMVTATTSSWFLLADGDGCVEEVEIRIVGPGGQFIMKLRSRDLYLCERSGKLHVARGEASVTKFLLQTTETGRTLLTTARGTRLYDNGEQGWMALPRNQCSGEALYMEFVSEDDKAVAMQGNWQSPYEFVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYH0</accession>
    <name>U4LYH0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_04569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="IRFVAGM"/>
    <dbReference type="OrthoDB" id="4704201at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21387" checksum="8B09DA2A74F978C8" modified="2013-12-11" version="1">MIRFVAGMEPGSAHHKRMVERATNGDHTHVTFGDGNINYGNIGASGFGAIHHLYDACHEETNFGWHKLNLHPQGQYNGWDERNIFVEAMVAAAGQEEKCEDKSWANGGGYGNWAHYEHGTERQCRQTNFISINRFSWEGYLMGFMSVLVELENPSNGWCAQTAGVMGAIAGAVGAAPSMAVGSALGAGLFGLISAFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUS6</accession>
    <name>U4KUS6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="258" mass="27690" checksum="A5CE96B777FB86F8" modified="2013-12-11" version="1">MSASSSAQRQFRAATLSPEPLAHLELLNLGKVSLGKKASMPLDYDVVTALARVETIGELVKQVPDTHRAHARGLIESTHKKMGQLLSLKSTVGALAEQKGSHPMCNCFHVPSLQFPQAASAGVKLVADTEVQRVTASCREELAKTLLTQYRSAANTLAKVLVGESLQKMAADSVAASTAAWRSALAGEDAMEVDTPMEPSEDPERAILDKYARRVIYSALLRAKSLAIISHDAAVASKKRKADLKKKADEESGGPFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUZ9</accession>
    <name>U4KUZ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to E3 SUMO-protein ligase pli1 acc. no. O94451</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUZ9"/>
    <dbReference type="STRING" id="1076935.U4KUZ9"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DNWRCPI"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="574"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1224" mass="136429" checksum="2C081989D997C0DB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV04</accession>
    <name>U4KV04_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935243">
        <property type="protein sequence ID" value="CCX05288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV04"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="17138" checksum="93AB2260F5CA76FC" modified="2013-12-11" version="1">MPPYLPSVTFSYNAAVGSPANGLWIPGPIGAFKPANDSVNINADGSPMLEKRVAVPAWGSKIGDCFHWISDHWHNFCHKPNPPNVPHPITVKPPSGLATPDDSPFGAHPHNGDFLPPGYAPGVEGEQAYLQDIAEVSHGNVYWENVIAGNKPVGGESLDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVR1</accession>
    <name>U4KVR1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Probable alpha-ketoglutarate-dependent dioxygenase ABH6 acc. no. Q5PQ59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX05051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG3200">
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    </dbReference>
    <dbReference type="OMA" id="KSPKTKW"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="104"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="255" mass="28498" checksum="8850975F04E1C89E" modified="2013-12-11" version="1">MSSHSATTTSTIPSLEESLVQSLPKTVYYIPNFISSAEEAQLLREIVSQPKPKWTILTHRRLQTHPSALTKNNVLLAAPLPPWLESIVPRMQQLKIWDNAPHKKPNHVLINEYNPGEGIMPHEDGGAYFGCVATVSLGASIVLDLYSKHTNADSGESGEAEAGAQKSTRFPKWRILQEPRSLLITTHDMYTDHLHGIQNITVDEDLNETTVANWTLLGDKEVFSTGRYERQTRTSLTYRDVIKVSNVGKLFGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVS8</accession>
    <name>U4KVS8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935232">
        <property type="protein sequence ID" value="CCX05081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVS8"/>
    <dbReference type="STRING" id="1076935.U4KVS8"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LFEWSLH"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="230"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX05081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="622" mass="66978" checksum="0DD800551268353C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW26</accession>
    <name>U4KW26_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein AFG1 acc. no. P32317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_05460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935274">
        <property type="protein sequence ID" value="CCX05873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW26"/>
    <dbReference type="STRING" id="1076935.U4KW26"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="583" mass="65509" checksum="07141153981F6D7F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW64</accession>
    <name>U4KW64_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_04903</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW64"/>
    <dbReference type="STRING" id="1076935.U4KW64"/>
    <dbReference type="eggNOG" id="KOG2547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AKMYVAI"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX05316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="582" mass="65460" checksum="AF4345C7C183B717" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWC7</accession>
    <name>U4KWC7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_05359</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWC7"/>
    <dbReference type="STRING" id="1076935.U4KWC7"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EWFKDEI"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
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        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="317"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX05772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="672" mass="77263" checksum="B339C4D2A3C5098A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWS3</accession>
    <name>U4KWS3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935278">
        <property type="protein sequence ID" value="CCX05982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWS3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6989" checksum="4EA9482A8FA70F14" modified="2013-12-11" version="1">MPPSITATDYGPYIDNTKRMSYPVSASAPAPDVPRRKEVVRSPGIGWILVAKWFRKWWRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX72</accession>
    <name>U4KX72_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935302">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX72"/>
    <dbReference type="STRING" id="1076935.U4KX72"/>
    <dbReference type="eggNOG" id="ENOG502S8RU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX06622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="263" mass="28001" checksum="100F314A1ABF7FD7" modified="2013-12-11" version="1">MYACTPHIESRELFRRAATPVPVRFTRLSPKAAAMSALQCLRVSRAASRTLSAVSRRAYSAAADAAPVDEPLVPGPSKTLGDSKSSIAAGTKLFNINYFKNKADPVALEDSEYPAWLWTVLDSGKKNAKGAEDVGDLYSKSKKARQLAKRAIAKREAEEAANPVKKIPIEEQTIDLPFATITNTAFEPAVTTPLTKTVSTVGPVGDSLGDKKAKTKPAFVSIGAGGAVQVTAEEAASARAEVKRALRAKGRAKIKEGNFLSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX90</accession>
    <name>U4KX90_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX90"/>
    <dbReference type="OrthoDB" id="10376552at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="383" mass="43111" checksum="719388C34DAAB622" modified="2013-12-11" version="1">MKPFVAAKLNCITPQGRFSVQQNPCSSMTYLRNMETYIDSLRTAVIAEYGDHTYRRARNDSGWLLNESLMKAMEKLDDISEGRDELKELAIEAYSRQEPIKYKLAEEPWDDIDPLDITPLTTQKGMEDFTKRLSKLAEERQEMEVEKEAKSYAKADEESNYDEDEVAEPELAEPSNEYVSEAEPAEVCVSKAESLDETRDVKLPALVLESPLKSVSAAYMVEDPLSPGTFVRSLWTPAFKAAPVEINETWSINQPLIRTSFEETVPELGYDSDTRSSTDTTSRSPSIANTPSWDSFPRPADLSKITFGTRLSSDDKSHSVGHSMVGLTPENVFIKNPKSPGSRRPKSRRMSEFLSKANTSITKNLKWTKNGTKSESMKTTINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXG8</accession>
    <name>U4KXG8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_06429</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="HF935319">
        <property type="protein sequence ID" value="CCX06842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXG8"/>
    <dbReference type="STRING" id="1076935.U4KXG8"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="359"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="595"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="777"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX06842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="855" mass="96168" checksum="B835408973354D9E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXZ0</accession>
    <name>U4KXZ0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_02012</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935202">
        <property type="protein sequence ID" value="CCX04409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXZ0"/>
    <dbReference type="STRING" id="1076935.U4KXZ0"/>
    <dbReference type="eggNOG" id="ENOG502RZQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARFWKQF"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="181"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX04409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="437" mass="48467" checksum="195BAD6E9CB8D118" modified="2013-12-11" version="1">MSQRPQSLTAELERIEMQITLAMQEIDANFARAHRIVTNSIIPVVERYQTQSDAVWEGSKFWRQFFEASADITLDAYQETTDTTIAEETTMRADNTGVSSPGSYREDGDKSKGMRMPTNDDSELLEDQFEDDTIMASLQMQSTPKPRQSWKEEETEPPYQMFAQELTEKYDLPAPDTNQQQMLEDESFIGVPPPSTPRTLKPPGYQTSETPKSSMMQPSTARAPPTTTPGRLLHQTATKSWRIQATPGKAPMSKYRASAASMIPSVTTPARPKQPNFNVDDSPFSSPIQFPELQTQVLNTPGPAALNARTPARLMTRDWGFTGGPPGTAKAKTPAKKTFAGYDFGDSDDDDIFLPPGFSPPKTMQFSIPASKLIATPAREASRRIVKDILQTAGADDTMTTTDVGNQRSFVGEESSFLEDLRGEPKRKLKEEDPFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ11</accession>
    <name>U4KZ11_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935346">
        <property type="protein sequence ID" value="CCX07256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ11"/>
    <dbReference type="OrthoDB" id="5490748at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="170" mass="19192" checksum="C3D609AD70481A33" modified="2013-12-11" version="1">MASTKSTPTTSSKHGMTMRGRTPKPKPTAATSAAHNKAHKSSKVTKVSKAPKETKATKTAKTTKASNASKNNNATKPKKLMARYIFSPKALETINLYKNKPNAEFVDGYVERSNKEQTAGIEITVSVSEEYQFLKWTKDMVFRDLMFAKELGMEMEDEEFRSRWENEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZB2</accession>
    <name>U4KZB2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZB2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3471" checksum="6DA8C168678CD0E2" modified="2013-12-11" version="1">MYCNIRHLSVILIRSFRNSFSSSGYTFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZC3</accession>
    <name>U4KZC3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZC3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="18" mass="2022" checksum="3FDB5C41AC2099AD" modified="2013-12-11" version="1">MGWCLSSPSHHPTSLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZH7</accession>
    <name>U4KZH7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Cell division control protein 3 acc. no. P39826</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_07184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZH7"/>
    <dbReference type="STRING" id="1076935.U4KZH7"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSNPMGS"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="66"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="442" mass="50564" checksum="A5B22D51853C40CA" modified="2013-12-11" version="1">MESDPEMSPESPKSAPPPVPIVSTNPKAAAQAAAAADAKNIVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPKEQKGPSLDIIPKTVAIQSISTELEENGVRLRLTVVDTPGFGDFVNNDESWRPIVDNIEQRFDAYLEAENKVNRMNIIDNRIHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKSDTLTDEEIASFKLRILADINHHKIHIFEGPSYDLDDDETIAENNEIMSKVPFAVVGANTEVQSAEGRKVRGRRYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEHTSNVLYENYRSEKLAAMGVEQDPSVFKEVNPAVKQEEERTLHEQKLAKMEAEMKMVFQQKVAEKESKLKLSEQELYDRHREMKEQLERQRLELEEKKQRIETGRPLEEKKGRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZY6</accession>
    <name>U4KZY6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Aldo-keto reductase yakc [NADP(+)] acc. no. Q09923</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZY6"/>
    <dbReference type="STRING" id="1076935.U4KZY6"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YVRECID"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="202" mass="22187" checksum="9F34813A605EF7C6" modified="2013-12-11" version="1">MGYPELSPDAAAYVRECIDESFRRLKVDFIDLVYVHRIDTTIPIEETITAMKEYVAAGKVGYLGLSECSADTMRRAHAVHPIAAVQIEYSPFALEIEDPKNGVLKTCRELGIEIVAYSPLGRGLLAGTIKSRDNSASSDSRRTFPRFSEENFPKNLENAGSANVQLSDEEVALIRKISEECTPSGSRAFTGDSSYGNSAQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZY9</accession>
    <name>U4KZY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935375">
        <property type="protein sequence ID" value="CCX07804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZY9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8785" checksum="F727F0B32CE836B5" modified="2013-12-11" version="1">MPGTHRSVRGRQLRLPIRNFSSLQHDRLRRRKSSGMSGEWKPMSVPRIGASQMMPSFSEYRCSLDDGMQFDSNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0G7</accession>
    <name>U4L0G7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935256">
        <property type="protein sequence ID" value="CCX05509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0G7"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="31" mass="3809" checksum="2E73233F1B821566" modified="2013-12-11" version="1">MSYSIPHAWLQQPQKRVIYRFVDRYDSSISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Q0</accession>
    <name>U4L0Q0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Mitochondrial protein PET191 acc. no. Q02772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_05206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Q0"/>
    <dbReference type="STRING" id="1076935.U4L0Q0"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KKTPKEC"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="11146" checksum="42FB38D23CA7A5F5" modified="2013-12-11" version="1">MPSSCADIRAALAACLQNSDCVMIERNKPIDCLRDPLVHTLPTRCQQLKKGYGDCKRGLVDMRKRFRGNKTVALTENEKGSSQGQLYAGKPAYQDPKSSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0S0</accession>
    <name>U4L0S0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935410">
        <property type="protein sequence ID" value="CCX08371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0S0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="49" mass="5811" checksum="7F145824085A7BA0" modified="2013-12-11" version="1">MTHPLYPTQCKGSQLYSLFPHHHRRHVPSRRRLIVRITSMFSAEDLPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L252</accession>
    <name>U4L252_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Protein OPI10 homolog acc. no. O60175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935524">
        <property type="protein sequence ID" value="CCX10230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L252"/>
    <dbReference type="STRING" id="1076935.U4L252"/>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="204" mass="22019" checksum="E7D65A04209B5093" modified="2013-12-11" version="1">MFGCIAAGRWVQTDMQTINETNFTFTISNGRSVNHIVIFILPGVIIPETHAATVHVRFPNSPDFKILGGISNSKPSAVFRLRGMLDPNSQLMLGGDDWNVVVGIAIQEVAVAEAALAQIPQTAAGEAGGAPSGALVVAGVTQRGAMGTLQLARRIISNAFNYLGSFSKNVGGEEMVPLAAFQEWWKKFEKKVEYDPSFLERPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2B9</accession>
    <name>U4L2B9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935117">
        <property type="protein sequence ID" value="CCX04219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2B9"/>
    <dbReference type="STRING" id="1076935.U4L2B9"/>
    <dbReference type="OMA" id="ITHTWIF"/>
    <dbReference type="OrthoDB" id="5413396at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="381" mass="43332" checksum="2EFAC8B1DB449058" modified="2013-12-11" version="1">MSSSNVTYPDLPKVESQDNFHKFFGSKKFNKDMEISTVKLDNIEVLTGHDNYEDWRDQMMIIFDAMQVSELVIDGATPAEDADDDEYEVFKALKAQCLLVLIQVLSKPIIKVVAKKCDPHAIWVYLENTYHCNTAFSFVQAIMSFTCLASSYDRSKPIMEYLDRFETEWNCLYNLTTGAKSTNTYRKKFRLFLEEDKAKRDFLLGFLVNPHSNVVDNVTTKDDLSYSDVVLKLHSLSSMDMQSVALKAYQPKGQGKKKMENSGGNSTKECTYCRKHHLGNPVGHTWNEFRKLKAKNEEKKKEEQPEEANVAKEEVSAHALATTKVSNPSITHTWIFNTGASSHMMSNKEHFESLSAYRGTVKIGNSQCLEVEGKAQSLQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2T7</accession>
    <name>U4L2T7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935524">
        <property type="protein sequence ID" value="CCX10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2T7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651063" evidence="2">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="5934" checksum="1340218571261E3E" modified="2013-12-11" version="1">MKRMKLLMYLIPLSVELGTSFSFIRYPSPWVPPTSNTLPASATAGTSSQPMFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3A3</accession>
    <name>U4L3A3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935314">
        <property type="protein sequence ID" value="CCX06793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3A3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="12585" checksum="746D04B5BF843BC1" modified="2013-12-11" version="1">MNTSESTSDRLYVTIGMAKHFIIKHEEYCHLRHLCIDRATLERKSLREAAWEKRGDILLSSKNSMSEIDKMIAMEEKYSTESATLLNVGQFRERMEVIIELMTTINTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3N7</accession>
    <name>U4L3N7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Osteoclast-stimulating factor 1 acc. no. Q8MJ50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3N7"/>
    <dbReference type="STRING" id="1076935.U4L3N7"/>
    <dbReference type="eggNOG" id="ENOG502SGWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="154" mass="16600" checksum="F7ABA5E63C20045C" modified="2013-12-11" version="1">MSTAIPTEDEDSKPSAQPSTDQASFLAAAKSGDTETVKQALIKNKIDINGRDTLGTTAWPIRSTALIEACNSGHESIVRLLLNRDDILVNQTDNGNNTALMIGCRNGRVSSVKLLLGRKDIDVILKNNDGKTAYDLCSKGISKKTKRLLKGRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4A0</accession>
    <name>U4L4A0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935642">
        <property type="protein sequence ID" value="CCX11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4A0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="203" mass="23574" checksum="8081E907E2A1C5D9" modified="2013-12-11" version="1">MKNLLEGLGMWRIIEDDEHRPLNPHAEAPEAHIAMRHAMQEAFDEKSRECITILKSACSDSIRPYVSRVGCPIEVWDTLERKLGGTTIYHARLALVIKFTDTKPKDGEPFEDYFAKLIDIRNQLHGTPDVITDAQFKAQIMRSMPAWMSITVQFVYQKEETKNKKSETTVTRHKSFFSTFKPFKEEHCPTLWKLISNHSHLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4D9</accession>
    <name>U4L4D9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4D9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11689" checksum="D6B360418545C6E2" modified="2013-12-11" version="1">MYQLLDPSLLRHDFVGEISQQTKYYSVSAWTAKLQRECTTEPVGKEHISCTSLPPVSVSLRASPHHKHTTAYVYETRNKNSNKTTLRSHLIMGLDWKLHMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4L535</accession>
    <name>U4L535_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L535"/>
    <dbReference type="STRING" id="1076935.U4L535"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HFLVRST"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="746" mass="81940" checksum="4B03C8BEA23D9813" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L590</accession>
    <name>U4L590_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Pleckstrin homology domain-containing family A member 8 acc. no. Q80W71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935595">
        <property type="protein sequence ID" value="CCX11129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L590"/>
    <dbReference type="STRING" id="1076935.U4L590"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX11129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="195" mass="21551" checksum="F1A86889C01ECA79" modified="2013-12-11" version="1">MATYFDTAKRNFKDVPLDASGKVSTTEYLEAAESAVALFDLLGNKAFVPVQKDMTGNVKKLRDRQLAHPDQSATIQDLVNNELASGSKTASEGLLWLLRAQDFTLQALNKNQASPTEELTQSFTAAYEGTLKKHHNFVVKGIFAVAMKACPYRVDFYKKLGDDQEKVSAQMKEWLAALDKIVGILSVFIAEKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5K0</accession>
    <name>U4L5K0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin-2 acc. no. Q01484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_11906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5K0"/>
    <dbReference type="STRING" id="1076935.U4L5K0"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="258" mass="29814" checksum="0D73C3D0E2A308F2" modified="2013-12-11" version="1">MASQYETPYFDNHSLGNLGIFPLEILLEIGEYSSTQTLGRLFRTNRYFHEIFTTPFYRRGAIVATENKSRHFNPAAFAIRNNHTSTLKKLLQHGLNGDTWIGLDKYERVSLLHLAIRPHLFKEQNDMTSAKLLLEHGADVNGTCKGYDTPLTFVLNLNIQNYRPWVDLLLKFGARKSINEGGQYSWRMSALHWAAEKGDVQLVKLFLDHGADIMMLDTPTKITAFMFARRKKNHRVMDLLKSRGASESRRGCWYWSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5V4</accession>
    <name>U4L5V4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5V4"/>
    <dbReference type="STRING" id="1076935.U4L5V4"/>
    <dbReference type="eggNOG" id="ENOG502SQSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SAFEWRY"/>
    <dbReference type="OrthoDB" id="5325862at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="28004" checksum="C50B7557719A89BC" modified="2013-12-11" version="1">MYTRSHQPPEYAEKPAATQIPPPSTGDTKGKEHPPIPPANPPTQSFTPRRTLTISTLGQSWFRLPLPPRNLVTPILRGPADTAYVSTRRARCSGDCILTTSSGEEVSKTSYFFGPGRSRSPVVSFYRGLEVLETRVESLGRICSRAAGFHLDGEKWEWRYETDVRPRIEGDDEMKTNLLVLYRSGTKVAELVRNDETRTEGTSWSYAGNGGVLVMGDVDEVVVVATAMVMLKREVDRRRLVQMMIIGGAAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4L600</accession>
    <name>U4L600_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_11830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L600"/>
    <dbReference type="STRING" id="1076935.U4L600"/>
    <dbReference type="eggNOG" id="KOG3489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WDVCFAD"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="10011" checksum="D3FDAED7D0FED782" modified="2013-12-11" version="1">MDASALGLGEFNEKDRKEIQSFIEKEQQKAKFQENVHSLTAMCWTKCLAQNKISGPGLDKNESSCLNNCVNRYIDAQKTVISQLERMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4L676</accession>
    <name>U4L676_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_11569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="HF935659">
        <property type="protein sequence ID" value="CCX11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L676"/>
    <dbReference type="STRING" id="1076935.U4L676"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="35756" checksum="F209E2EA32CE8725" modified="2013-12-11" version="1">MSSIVNKYLQTPTEVGVVAVGFSGGQQKDGVDIAPQALIDSGLLTTLRDDLNYTIHHDGVVHTYTKLFPTSDPPLHVSGAKMPMLKPQTVSNATEALSSQVYEHAKEGRLVLTLGGDHSIAVGSISGVAKAVRERLDKEIAVIWVDAHADINSPQTSGSGNIHGMPVSYLCGFSSAPAENPSVFGWLEKNHLINPKKLVYIALRDVDFGEKKILRENGIKAFSMHDVDKHGIGKVMEMALEYVGDSPVHLSFDVDALDPMWAPSTGTPVRGGLTLREGDYICECVHETGLLVAMDLVEVNPNIGPRDGVDGVLGAAETVRAGSSLVRCALGESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7J3</accession>
    <name>U4L7J3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Probable vesicular-fusion protein sec17 homolog acc. no. Q9P6A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_05582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935278">
        <property type="protein sequence ID" value="CCX05995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7J3"/>
    <dbReference type="STRING" id="1076935.U4L7J3"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="355" mass="39390" checksum="8A6807530539AFEB" modified="2013-12-11" version="1">MESADSIYSKAQSMLKSARGGFNFFGNRRDKLEDAAEEFRNAANRYMGEQKHETASACFVEVAKIQNEINEGYDAAMAYVEASKCMNAADLAPPVRAEKAADLLSQAITYFTTTKVDYYRAAKLQEQLVAILESGDRLQRAIRECKESGKNYDYGQVTASATGRKMYLKAAELSAKLGMADQEEEFVIWTGETSSNYENITTGALHEAISLFEKVAAGYKQSGAAATWTIKECYFKAALCWLMIGCKKNEVDSINMALTKYCEMDKAFPTYLEYGADIPQSLVQAIEKKDREGFVQIRTTQAARFSTLPEWAHKIFAACEENFFYAAPAPYVYQGEAGGEGMVADDDDDGEIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7Q3</accession>
    <name>U4L7Q3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7Q3"/>
    <dbReference type="eggNOG" id="ENOG502QQNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVCFAMA"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513">
        <property type="entry name" value="INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="507" mass="55362" checksum="7F60BCE0FE0FDED5" modified="2013-12-11" version="1">MAGGVTKVLNSWAVFTPTEKKNITVYILGIMLYKFGLEAFNGSIIALATNRYDFGGSLNTLERIGLLTGLNQAFQCVGSILIAPLIRRYPTKVVLSSAIFLFGLCTAILLIVDAATGGKIVPKGWHKANGKDDFTYYGDYNTDAIIPIYCVAGIVYGMVELIRRIVPRDIVGGNVQKLRRMDALVHIFYEVAGTSGAFCTALALIPRLGNNYSFIITPIFFTAAAAMWMFLDVEFTQEPVSNSLEGKPSYFKSVFSGAVLFFDSVYTGGKILFSSRKFIWLLPGYSIALYAHRYLENGVAPQIAKRYLGHSAWAQIMVGGSNFGELLGALFVFLFTNFIKTPIPWLRLDALMLMVDAWMVAATFLPVSFGWAAGDVSLAAYIQAALARMEGSSRNVSSLGAVMAFLYSVYIVLYAITSPLLGRYLDGVYTRSGGKNGGDIREGLKMTAGVQFTIIAGLILMATFVPKGAFALNPDKLFEENLDDEVAEGKDIDEDQKEEKMVPVVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8C8</accession>
    <name>U4L8C8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935967">
        <property type="protein sequence ID" value="CCX14376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8C8"/>
    <dbReference type="STRING" id="1076935.U4L8C8"/>
    <dbReference type="eggNOG" id="ENOG502S6GP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRMMHVT"/>
    <dbReference type="OrthoDB" id="5350192at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32706" checksum="5266291E107B3E94" modified="2013-12-11" version="1">MGQKPSTSSISYPLPFDKEMDASSILRGLEYVSRDLRRKREHVHLIVGGSSLSCLVYKSKTTCLGLNLIFVNPPSAKTLTTLTRSVARAQKLFNLSQNWVNTTLEASIPAEIRDNVIYQSLLQNDIVFSSEGLTLLALDHCFALKSTLDRLSRGSWDASLDSSVEILRRLVYISRGRPMTRGYIAHSHKTIQIPDNVLLRLNAEYEAQYGQRGIVGVNDDYLGWRREGLTWSAELEEYGQELAFSLSRSSTPDSQSSYLEDKPLPELPLRNRDTIQAIFDSPVQRGGEGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8E5</accession>
    <name>U4L8E5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized HTH-type transcriptional regulator ytcD acc. no. O34533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_14167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936026">
        <property type="protein sequence ID" value="CCX14573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8E5"/>
    <dbReference type="eggNOG" id="ENOG502T0HJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKCVILC"/>
    <dbReference type="OrthoDB" id="10068216at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF29">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX14573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="13561" checksum="54124BB4FB30C810" modified="2013-12-11" version="1">MLELVGGKWRILILYQLISGKKRTSELRRAIPGITQKVLTQQLRDLEKNEIIHRIIHPQIPPKVEYELTEYGLTLQNIIDRICLWGENHLDRVYGDKSKVLENHFSEYIPHYPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8U9</accession>
    <name>U4L8U9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935793">
        <property type="protein sequence ID" value="CCX13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8U9"/>
    <dbReference type="STRING" id="1076935.U4L8U9"/>
    <dbReference type="OMA" id="KVEICYE"/>
    <dbReference type="OrthoDB" id="5372780at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="776" mass="84315" checksum="003262C6C30CDAA2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Y8</accession>
    <name>U4L8Y8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Mitochondrial aspartate-glutamate transporter AGC1 acc. no. Q12482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Y8"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="9946" checksum="11BB0E7EC8D7BD87" modified="2013-12-11" version="1">MVKIRLQVQDELTKNVVDTPRRSELRIVKNLGVVDLYFPAYAYLKKDWFGEFPTKSLGIAQLLTAGAIAGMPAAYLTTTCDVTKTRPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8Z0</accession>
    <name>U4L8Z0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX09991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8Z0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651755" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18300" checksum="ED96194A9A3A536D" modified="2013-12-11" version="1">MLHIYFLFCTFGRICWLEIDTIYLEKVYFVPNEISNSGYLDRFIGFLAFGNGIWCCTTREGKATNVKRAAKLKRRIANASHHRGYLGVVSHQRQPFKISSFNFRVKASSKHLGHICCHRTSVRRSSDLNFPSAQRTDFMKSQKSTCLRASLGSVSAGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAT5</accession>
    <name>U4LAT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to UPF0361 protein yoqW acc. no. O64131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAT5"/>
    <dbReference type="STRING" id="1076935.U4LAT5"/>
    <dbReference type="eggNOG" id="KOG2618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
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            <end position="399"/>
        </location>
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        <location>
            <begin position="435"/>
            <end position="550"/>
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    </feature>
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            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
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            <begin position="443"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="485"/>
            <end position="514"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX15459.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX16306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="669" mass="75075" checksum="0925B988A7E38E11" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </source>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCX15962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="8204" checksum="27C4AE8C86223F52" modified="2013-12-11" version="1">MQTTCVGNMRLVTRCTYMERCPWGSAIDERRDLCAVDSTPIRKLYLRLTQLCSRDQRMKPKIRQVTIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCC9</accession>
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="364" mass="41223" checksum="37A9ED41B2C5A6B3" modified="2013-12-11" version="1">MSNFESPLQSPTNDGRALNWVLDHVTTHEETYGDIYPARLPLRTIFTLNCQTGASSPNTFRGELMKLLSDLPAQPCTLPPIFLTSFIKKCFPADFTSVDFDQALTALDYLRDLDMRRKNEVEKATKAKGQHDTKIKQMQNRLQKLDLLYAKALVGIRRFTLIHELSAPKFSRVQCSALLNTLYPLEEEDINLHLTAPQLSKQRQALWGYIIGVQQNGPGILDGVKGYNGGWKQISEVIYAYCKLSLELIQKAEDLTRPISYGSFQSDVSIEEPQSPRISTKRRDSDSRSSEGEFEGNGGRRSTLDKLVRGLQLAQRFRKKSTNKLGNSEWNSSKGKLYQSEFNSSQKGLAAQEWQQREEVSMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCV8</accession>
    <name>U4LCV8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_03466</name>
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    <organism evidence="2 3">
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX16721.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="11886" checksum="F2E95204A3068CE5" modified="2013-12-11" version="1">MFDFLETFADLELDDFTISPDTRRWIREHLSDTYHALNIDMMTFSNFFGLLLCVVIYVILRAFNRLAKNPLLELDWHKKWFVALNWFTMTAVGRKLYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCW1</accession>
    <name>U4LCW1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCW1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="90" mass="9927" checksum="994CDA7CABDD0D45" modified="2013-12-11" version="1">MLPPTLPFHSDSGEAVDVSAMPKMYAVLFVVMYIFFSASEFSSVVNLRLHQRLVRWLGEGALVGNIGRQSCDLKGIIYTAGDFDMILGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCX2</accession>
    <name>U4LCX2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCX2"/>
    <dbReference type="OrthoDB" id="5379822at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651249" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35950" checksum="40BE7AC5A1C1A79D" modified="2013-12-11" version="1">MTRKRKAIFSIVLLVLFLVASVCGHDILVFNDTTGLPSCAYSCKDLYSAQFECPPGANGVGCFCNSQFISKKSATWGCDESCVVEGNRRRVSGFLSAVCGTRGSGNEGNDDAKSDITDAKKDPQTEKVSDWWKRNWPYFFLSFMIVFIVILTLAFVGPIRRYIRRQIISGHSRGVGQGVPPYWEPTPPGSRVSYVPFSQRSPQQTVLPTHSRTWNGRSSTPMIQTEYRGSTPYLNQGRSVSYIGVNTSTPTLAPPPGPPVRTLFATQVEDPTKQENWERRAQTLHESRGWFARNVFWKKGDATENTAEKGYQSVDPNNIGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCZ3</accession>
    <name>U4LCZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCZ3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="94" mass="11075" checksum="1FCD8CD86D2793D5" modified="2013-12-11" version="1">MICHKMSRINTDGKCCKLFSDKDRNKMTWSSKKNIGKTCMMIKTVFRTGSATQSVARSSRGDTRFSVPVRGFTWRFRRINWCNRVYLLNRLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD40</accession>
    <name>U4LD40_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD40"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX17417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="5887" checksum="018B697698C1B340" modified="2013-12-11" version="1">MQSEFCVSRVVQENLDNACISLVLVHTCTQREHTSSSRPTVPQLVTAQISQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD66</accession>
    <name>U4LD66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD66"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="500" mass="48329" checksum="4A58B1701DC257D8" modified="2013-12-11" version="1">MFTKHNGVDVMQAVQVGEEEKKSSSWGGGIWNGTANDTIGIHNGTDIRVNGTGIVWLNSTDTGEEEGMGVTQLPVGTDSMDEMGAGNAMGEGNGTDKMDAANDKKVVHTTVVVNATTSFNSTIAGYGMERNTTVAALQTGESNSPAGGSEGGEKGTKVVYAMEVVTATMPGNGVQAGDSMGANPTVLPPGESLTVGDGPAPTGSPGSPGSPGGTGGDSKTKVVYATMVVNTTASMAANGAAPVDVAISGNSVEEPNPTASLNVATPTTDMGGASMTIGGGPVILENGTPTQSSMGENGTGGNGAATTDAPGFPVPPVSPGEAKTAVQYVTVVVNATVPVNGNAAANGAQEVSGTPTVSGANTVVTVTTVPDGNPAVNSAPEASSIPAVNGAIEGGGAVEFAQNGAMVGGGTTGNGAVAGNTGEPAKNAPLGGAGGGGSNETPSPGPTGGAGAQNEGNVGDGAQNPAAPQTTMVGADVDVPMDSTIGQLELGNGVEFTVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDH8</accession>
    <name>U4LDH8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935432">
        <property type="protein sequence ID" value="CCX08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDH8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11570" checksum="8DEC8B5812BAB5D7" modified="2013-12-11" version="1">MVDQSQFPSQIFRIDPQFKRRHFQFLNTSESLPRFPRQREGISIRLCILQTALESVPTHISQVHTKALAQEQPIISTGNTSDHHNPRSSMQHGNSQATHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEE5</accession>
    <name>U4LEE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEE5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4284" checksum="8A0902F071040BD0" modified="2013-12-11" version="1">MTGVKFDVWLSYVTQALASKSVGHPTILISFGSSNLQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEL0</accession>
    <name>U4LEL0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEL0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12843" checksum="B2D88DC2C33D593E" modified="2013-12-11" version="1">MSTQQDSTEPENDKTPVWIDEARYFEDMARQDEWKAAMATAWLQVNFPEGKELHEHDEAAGADETKPDGEMGMEVDETGETSVKNKGTDVGPAGENSEEQEEPAEVMECDEMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEU0</accession>
    <name>U4LEU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized J domain-containing protein C3E7.11c acc. no. O59731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935415">
        <property type="protein sequence ID" value="CCX30067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEU0"/>
    <dbReference type="STRING" id="1076935.U4LEU0"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RPALMDK"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="505" mass="56176" checksum="D73A964B9D75BE76" modified="2013-12-11" version="1">MVKETEYYDVLGVTPTATELEIKKAYRKLAIIHHPDKNPNDEGAHAKFQSISEAYQVLSNEELRKQYDQYGKARAVPDSGFEDPSEFFGMIFGGEAFVDLIGEISLMKDLTKTMEIMKEAEDGDESESEDAPQKEVNDNDAAAGAAAAGAATAGPSDKPATTEPTASASTDAPAASHSAPSSLAPEEKDVPARSAASTPRPGQVPTRMMLTDKSDEEMREVEGMTEQEQELRRKEKKKGLSKEQRDELAAYEAERKKVRQERVDNLAKKLVDRLCVWTETDKTAETTHAFNEKTRYEAENLKMESFGIDILHAIGAIYISKGASFLKSQKFFGIGGFFSKLKDKGTLFKDTWGTISTAIDAQMTMEEMAKLEEKGGDDWTDEKKAEYERKVTGKILAAAWRGSKFEIQSVLRDVCDKILYDKTIPLNKRVERAHALVMVGTVFKQAERDPDDEFAEGAFEQLVAEAAKKDDKKDTKKKEKEKHHHKKASREESEEMNMPGAGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEU9</accession>
    <name>U4LEU9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEU9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7716" checksum="B678E7E070CC5ECA" modified="2013-12-11" version="1">MDQLSKLQSNRLPIPSTGVWYESSRPRIRMHQGLKEPRILTVLNSIYRLKDTQYHGPGNPVGFAPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFY0</accession>
    <name>U4LFY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Cell wall mannoprotein PIR3 acc. no. A6ZZG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LFY0"/>
    <dbReference type="eggNOG" id="ENOG502STWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651334" evidence="1">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="350" mass="37182" checksum="4977FD021215A82C" modified="2013-12-11" version="1">MVSFSTVFVSSLLAYVEANQDANLAPRDPNMPAVNQIADGQIQIGIPPVSQIYDGQIQIVPGQLPPVNQIIDGQIQIGLPPVNQIIDGQIQIXXXXQIQIAVRDLPPVSQIYDGQIQIVPGQLPPVNQIYDGQAQIQNGIPPVNQIIDGQIQIGLPAVSQIYDGQIQIVPGLAPVTQISDGQIQIVPGLPAVSQIYDGQIQIVPELPAVNQIYDGQIQIQNVIPPVSQIVDGQIQIGIPPVSQINDGQIQIVPGLPAVSQIYDGQIQIVPELPAVNQIYDGQIQIAVPGLPAVNQITDGQIQIAINKRADSSNALAMKRPELVSGSSRVQIAGYAWVGACLVLGVALISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFY9</accession>
    <name>U4LFY9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Transcription factor tau subunit sfc3 acc. no. Q9UST7</fullName>
        </submittedName>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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            <strain evidence="3">CBS 100304</strain>
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            <begin position="74"/>
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            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX10914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="779" mass="87157" checksum="17FB196A6F567052" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000018144"/>
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    <sequence length="221" mass="25626" checksum="4399DA9D9FB2930E" modified="2013-12-11" version="1">MSEFSIPFLDLNHKRDCTLYTPDLFQHPLLKLSPKKIGVQELFNNYMMADRHGEYSIPCLIPTSPIDYSIDCGNSKTLGWICFECHQSSKWHWSTQLEPIERIRFPVEDIIKQARSEQISRHECVNRRLPNCAAVLCVYEDGYFQKDEEHLLSESKDKVEHWVAIWDEESSKMRKPPPKHVFKVPSPEGSEAGLLQQPGCGAKEFTGFWSDEEEPLGPWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGX1</accession>
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        <recommendedName>
            <fullName evidence="5">Clock-controlled protein 6 acc. no</fullName>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 100304</strain>
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        </source>
    </reference>
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            <end position="162"/>
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            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="16740" checksum="49FD0FBA515C3FAC" modified="2013-12-11" version="1">MQLSFSPAFSILLLSSAFLVRGHPDQPSATATEIGGDPTVTVEASLFPRGNSTRPLDLWCSHPARPKSEQSWCDHPVRPQPEAEQPKTGLPLPAATTDKLGLQIPIGEGGCAVCVTGTDTSSKPRKTSDIAAVSGGTKRTPEVGWVVAAGVVAVLGGVLGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGY1</accession>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="757"/>
            <end position="785"/>
        </location>
    </feature>
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        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
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            <begin position="757"/>
            <end position="785"/>
        </location>
    </feature>
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        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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            <begin position="70"/>
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        </location>
    </feature>
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            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
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            <end position="138"/>
        </location>
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            <begin position="638"/>
            <end position="650"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="865" mass="95139" checksum="23B15A4B322FF456" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHV9</accession>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHV9"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="8011" checksum="D850A2A5E3B229A4" modified="2013-12-11" version="1">MCLPLPSFLTRRRREKVYYPVPPEPDANAVSSWTYVPPSRPYTPPATIRPPTLKPSKAIYFTPDGKYTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIK6</accession>
    <name>U4LIK6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Zinc finger protein YER130C acc. no. P39959</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_11768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935680">
        <property type="protein sequence ID" value="CCX12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIK6"/>
    <dbReference type="STRING" id="1076935.U4LIK6"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001177">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="518" mass="56969" checksum="A51884B2BC31CFFA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ32</accession>
    <name>U4LJ32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936535">
        <property type="protein sequence ID" value="CCX16892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ32"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4972" checksum="DD2E5ADA37995F5B" modified="2013-12-11" version="1">MRPPSELHLERRMLRVLTRRDGLRFRKKCVSLPQTGPPQISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ96</accession>
    <name>U4LJ96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935722">
        <property type="protein sequence ID" value="CCX32023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ96"/>
    <dbReference type="OrthoDB" id="10442451at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="20114" checksum="2ACE22D184F31895" modified="2013-12-11" version="1">MSHPELVLLHRFASSATTTMALYGLKIQPPQQLRRLKRHASSTLAKTRDSSRDPTATESKGMIEDPDIASYWLLFFCIRIPRISKSTKQKQPSTRNPTEYSPSSSLSRASNIRGYYDNARSGEQMVISRFRMSDYEVPLTSSATKHKFRQDIRLDSVQSNKTVYYPAEEGQDSSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJI5</accession>
    <name>U4LJI5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Probable maintenance of ploidy protein mob1 acc. no. Q9P601</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJI5"/>
    <dbReference type="STRING" id="1076935.U4LJI5"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDNEQMF"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="237" mass="27467" checksum="0976206394C894AE" modified="2013-12-11" version="1">MTSFINTINQKTHARFKPKSSTRGTSSYQLRQYAEQTLGSGSLRKVVKLPEGEDIDEWLAVNGLAPSLYIWSCPLMNIITVVDFFNQINLLYGSITEFCSPTTCPEMKATDEFEYLWQDNNKYKRPTKMPAPEYIEHLMAWVQGYIDNEQVFPSRIGVHFPKNFQSTVRQLVKRLFRVYAHIYCHHYPVIVALGLDPHMNTSFKHYVLFIKEFNLESGKDFYGPLSDMVETILKADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJJ6</accession>
    <name>U4LJJ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to L-2,4-diaminobutyrate decarboxylase acc. no. Q43908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJJ6"/>
    <dbReference type="STRING" id="1076935.U4LJJ6"/>
    <dbReference type="eggNOG" id="KOG0629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHVANHR"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115120" checksum="89D57FF0B3701638" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJR3</accession>
    <name>U4LJR3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Upstream activation factor subunit spp27 acc. no. O74503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935809">
        <property type="protein sequence ID" value="CCX32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJR3"/>
    <dbReference type="STRING" id="1076935.U4LJR3"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KVWQYIR"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="287"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="42068" checksum="930BE6648037DE4A" modified="2013-12-11" version="1">MFIIRELLKRVRIRRGEAAQQSSSRVYAGCNNRYENDDYNHCFNQRGFSTINVKYNYFYTTTPIHPPTQFPHRTAFTTNTPRISTQLKCPINRYRIKAYTKEEMSTLTLSHDDEEKFTPLIDEILRSSDLSTVSVKKIRNALAEQCEIDFTPLKKSIDALITSRFDAILAERDAASPSPEPVPSPSVSLSPKASAEPESDSPSALGTSTSTPAKKRKSASGDEDARLAAELHAKLNGGRPSRGTTTKKVKKPAAKGKAKKKSKDTVESDTDGEKPEKKKRKVGANNAFMKPLILSAPLADFIGETQMSRPEVVKRIWAYVKENNLQDPQDKRYILCDQSMKPVFGDKVHMFTMNKVLASNMYKPDEVAGAPAGGEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJZ4</accession>
    <name>U4LJZ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Multiple myeloma tumor-associated protein 2 acc. no. Q9BU76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935761">
        <property type="protein sequence ID" value="CCX13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJZ4"/>
    <dbReference type="eggNOG" id="KOG4520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DLEWWSK"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="18742" checksum="D75D788709D386B2" modified="2013-12-11" version="1">MDLLSGLRKGDSSRGGRAEFSWDAVKEDKDRENYLGHSLMAPVGRWQRGKDLTWYSKAGGGDADAEEQRKEEIRRIKEAEQDALAAALGYPVQMRRESLDQKDVERAIKDARGDDDEEGKGVGFGKSGVAALEREERPRADRAMGERERGERSREGRPREERKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK15</accession>
    <name>U4LK15_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935844">
        <property type="protein sequence ID" value="CCX32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK15"/>
    <dbReference type="STRING" id="1076935.U4LK15"/>
    <dbReference type="eggNOG" id="ENOG502S1KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LQERYWR"/>
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    </dbReference>
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            <end position="301"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX32434.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="396" mass="44181" checksum="5BBBD33E4401B5DF" modified="2013-12-11" version="1">MSPPKNWAFSGSKKGTKHLAKVASMPRPGSRLGGCTAGDWAIGAPSSSSGVTKTVTHRRTPTAKRRAIRTVRTNGGPSDLSITYEGGDYDVASCVYKVQISTDFTPKTPSPLKKKLPGSKLRILGVPEKPTTTNTVAQGVEEGTLVGDRRKGFEITPHSWYDLPLFNDLQILGECYFPGDYILVNNPCTSHSGMISTSEDLRRFWVAEIIDIRAESTESVYLRINWMYWPEDLPIGRQTYHGAQELIWSNHMDVIDAHTIAGLAGVTPWNEDDDKSDNIDLGELYWRQSYDPQTKHITSLRRHCACKGYHNPDTILVRCEACDSWLHEGCLADSIKKDVLVTAGIITGKGKKGENSKMQQLVNVEWDDDISRMFVAFDGDEWYEKAKCLCCYCYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK43</accession>
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    </protein>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
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        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="14705" checksum="66E4BCF67A39E3A9" modified="2013-12-11" version="1">MADVEAELTREQKKANSARRYAQKQIEKTRRKRDNRLKLAQLRWKERERVKEEALREKEGRKLELKEWELPGEQLRREEKEHLKGPMPKHQVMATVVQDETAREDAAGKKEIKQEGASITAEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL57</accession>
    <name>U4LL57_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="91"/>
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        </location>
    </feature>
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        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="654" mass="69981" checksum="6DC543C658982C5E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL92</accession>
    <name>U4LL92_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG3283">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
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    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="204" mass="22636" checksum="046D2F4A2B4F66B7" modified="2013-12-11" version="1">MGISRDSRHKRSATGAKRSHYRKKRAFELGRQSAVTRIGPKRVHVVRTRGGNRKFRGLRLDSGNFSWGSEGISKKTRVIAVAYHPSNNELVRTNTLTRSAIVQIDAAPFRQWYEAHYGLPLGKRRGQKAKEEAAAAEAVTKSKSVERKLAARQTTAKVDGALESQFAAGRLLACVSSRPGQSGRVDGYILEGEELAFYQRALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLG1</accession>
    <name>U4LLG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein phosphatase 1 regulatory subunit 3C acc. no. Q0VCR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935976">
        <property type="protein sequence ID" value="CCX32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLG1"/>
    <dbReference type="STRING" id="1076935.U4LLG1"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYSKAVH"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
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            <end position="425"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
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            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
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            <begin position="428"/>
            <end position="459"/>
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    </feature>
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            <end position="504"/>
        </location>
    </feature>
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        <location>
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            <end position="642"/>
        </location>
    </feature>
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        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
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            <begin position="9"/>
            <end position="24"/>
        </location>
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            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="718" mass="79252" checksum="EB21BF22354B5207" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
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    <dbReference type="EMBL" id="HF935907">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="reaction ID" value="UER00503"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
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    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX32898.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="523" mass="58547" checksum="21E135154762249C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMK7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_14223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="OrthoDB" id="5420013at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="770" mass="87542" checksum="591AA6C565BF212F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMK8</accession>
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        <submittedName>
            <fullName evidence="3">Similar to TBC domain-containing protein C4G8.04 acc. no. Q09830</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMK8"/>
    <dbReference type="STRING" id="1076935.U4LMK8"/>
    <dbReference type="eggNOG" id="KOG2058">
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    </dbReference>
    <dbReference type="OMA" id="WQDYLRI"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000046">
        <property type="entry name" value="TBC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
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    </evidence>
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</entry>
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                <person name="Freitag M."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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</entry>
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        </submittedName>
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            <taxon>Pezizomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        </source>
    </reference>
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        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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            <end position="163"/>
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    <feature type="domain" description="EF-hand" evidence="7">
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            <end position="230"/>
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        <location>
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            <begin position="103"/>
            <end position="124"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50222"/>
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            <dbReference type="EMBL" id="CCX30760.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="37885" checksum="CD11D2EACDB363E2" modified="2013-12-11" version="1">MAYHNTNPDALPAHAEPEQAAQLMSNNSNYHPTMSQSPRPSQQGGYPQQRPPQGYNQHPQQHYSPQQQHGFQQQYGGQQGYGQQQQYGGQQGYGGQQQQYTQGPPPQGPHGRPPVQNRPPPTPAPQQGTNPTLYPLFTAVDKDGSGQLSERELRAALVNGDWTSFDPHTVKMMIRMFDTDRSGTIGFQEFCGLWGFLADWRKLFDRFDTDRSGNISYDEFTNALEAFGYRLSPQFVNTLFRSYDRRGQDTAPYPEGGTSSPLVPHPPILSIPTLILTLTYSLQAEGQNAISFDLFVQSCISLKRMTEVFKKYDHNRVGYITLSFEEFLTEILRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNM1</accession>
    <name>U4LNM1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNM1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="169" mass="19886" checksum="445CB09073D98433" modified="2013-12-11" version="1">MSRQPLTQRNIQRHIAWCEAQPKKENSRDYVPYEISPHILSAAKGQNPYNRMLIIKMLMLLDDVADFEDNMTGRWRNMTDAHEQDEISWKDFIPQLGGLAIDLLKESKHLDKEEDRMSDMAYDQLCKLQNAIERLRGYVMMYGDKQVIERIVTWISLMESEKCRVPGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNV1</accession>
    <name>U4LNV1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to conserved Plasmodium protein [Plasmodium falciparum 3D7] acc. no. XP_001350695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNV1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="440" mass="51211" checksum="0518D554DC1BCF82" modified="2013-12-11" version="1">MAPARNVNRRNINQLPHTIKENDGNDGVALWDKVIQHHRRMVYPATALSEDIEEMIEDMRGGYGERCDGEEGYRKEDRRGERKVVEDDIEWDGLENTAVEVDSIEERNYESDNSEERNYESDNSEERNYESDNSEERNYESEKSEGKDCEEYDTGEEDECEEDGYEEDDSQEATYEEDESGDQETPQSEVGSPNDYSGCCTEDPDISESEMVSSVSFSIWHRLLTYHLQHCNPSYLAHLDKPPNSFTDISEYCDHPECISLDRKTGWEDSQRNSFESRKCTNCGIILCYTHLLSIGIITTHCEHERFCDWRSTAHNCEHRECQVWLRRYNDRRWLYPNMPLIKDTKLCMDCLRSFCGTHRKRFEEANARRKGTVVNSPSATDQGQGVSFNQIPVERPKKGKKYQSIRQVVESPEMAGGERVSPVHVNAIIKNSRKRRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP48</accession>
    <name>U4LP48_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP48"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="621" mass="69542" checksum="1ABB974F54D0D821" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPT0</accession>
    <name>U4LPT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to 37S ribosomal protein MRP51, mitochondrial acc. no. Q02950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPT0"/>
    <dbReference type="STRING" id="1076935.U4LPT0"/>
    <dbReference type="eggNOG" id="ENOG502SBK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NWGLKRD"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="393" mass="44577" checksum="132478A032D2FDAA" modified="2013-12-11" version="1">MSTKTLSPAANLLRRSRLMSMPAPIQPPQSFSIHAPPAAPYPTVQAITTPRSSAYRGDWGLKRDLPIQVSQKTVYMRYNDLDTIEHMTTFESAHDDVYTLRKWQEMDIPLMKDQAMDDFGSYDPRVEKNFQYKSTVFDGVEEPEKYKWRYKGPYVAGMGEKKLKAYIEERIIPQKEAFTKFVAQRQAVEELKQKYLQLNDDRSIADIEAEAVTIADVNKVDLMSLRAEPQYLENLVIDFLDIPRQKPNRTHPSAGLHYIRSSAYAHNDPKLGPQEQKKEILGRPLNHHGASGSLVGVGGVVARVSSSYAQRRHVNDRDRSAVQPFRPVKGAHINASGKILLDVERVAPAVQQASWSFTDMVQRRGENQHARKSEFSGQTEKIIQMLNVGGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQ96</accession>
    <name>U4LQ96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to NAD-dependent protein deacetylase hst1 acc. no. C8V3W5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQ96"/>
    <dbReference type="STRING" id="1076935.U4LQ96"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTHEFIR"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="132"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="504" mass="55800" checksum="78555B994A7CB223" modified="2013-12-11" version="1">MSAPQAPPTTAIIEDSESELSELSGYDTVPEVDSDDENEAWDSESLLGDALDEMKTEVFDEEDDAVTPEERKQLKALLKSMGEDDFIHAVVQKGGMPIRKLLTTFQPSFMPDQTLYTILQIVVGKEMIQRTRIPHVNSVEHVVDLLRKSKNIIVLTGAGISTSLGIPDFRSKGSGLYSRLESLGLNDPQEVFDINIFNDDPTIFYSVAKDILPETKQFSPTHAFIALLQSKNKLLTQYTQNIDNLEHLAGILPEKLIQCHGSFATASCTKCGHKVPGETIFPEIKRCQIAKCDNCLRLLAESSAAGKKRKRSKKPTNSSNKSSPNPSGTGTPNPSTKPAVKSKPKPSKPADMSWPKKKRFSEDSSADEEESNFREAGVMKPDITFFGEQLPDTFHKRLVGQDRMKADLLVCIGTSLKVAPVSEIIGFLPENVPQIYISKTPVNHIEFDVELLGPCDEVVAELCRLAGWTLTHEMLPSSHPKVLWSRIEGPGNRYEYIDQDISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQB8</accession>
    <name>U4LQB8_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQB8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="70" mass="7829" checksum="2AC998FE4AE7C0FC" modified="2013-12-11" version="1">MYAHLCFHSIFPCVLLAEKDIGNYGALSKRDVRRGNVVRSMSMRASGCMACRIHKGRMYISIGPLLELAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LR80</accession>
    <name>U4LR80_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936600">
        <property type="protein sequence ID" value="CCX34696.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651844" evidence="2">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="14264" checksum="C415D1870E48D6C2" modified="2013-12-11" version="1">MKLVATTIISLMAILAVAAPSADPAGPKTPPAPGSKDNKDLSPHSKSTSAGAPAGSDCYWIDGKTQKAIYGKWVCCKKEIESGAIKSITCVKHDLWVKLSKPTCPKAHPTATCCPVGKDFTNGQGCNDNPNAGVAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRA1</accession>
    <name>U4LRA1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_03749</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRA1"/>
    <dbReference type="STRING" id="1076935.U4LRA1"/>
    <dbReference type="eggNOG" id="ENOG502QSB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKQKKAP"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="362" mass="41010" checksum="8008A007BE58FC2A" modified="2013-12-11" version="1">MLTTKHTCVKALPRLSAQLLPVISQLSRHKPASVILLQHARSISSSPAAQDPRLQHLKINPEYVASWSHPIYTESQMKSIEIAHRNAETWSDYVALTAVRIFRSCFDFATGYRHEPHAPQSITMDPKSPAANSMVSSSQTFTSDQWLTRIIFLESIAGVPGMVAGMVRHLQSLRLLRLDNGWISTLLEESQNERMHLMTFLHFRQPGWFMRAMLLAGQGVFFNAFFMAYLVSPRTCHRFVGYLEEEAVLTYSRVIEEMEKGNIAEWEKLEVPEIAVGYFGLLKSQDSPKGGMLELLKVIRADEAKHREVNHTFANLRGGDVNPYAVEWASGPTKGLERVRQTGWEKEELARVAEAEGKFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSL1</accession>
    <name>U4LSL1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Septin homolog spn3 acc. no. P48008</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSL1"/>
    <dbReference type="STRING" id="1076935.U4LSL1"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GYDSAMN"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="15"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="376" mass="42698" checksum="56D753B0667B186E" modified="2013-12-11" version="1">MSGMHPVRRKKQMKKGIQFCLMVCGASGTGRTTFVNTLCGKQVLQSKDADDAENAHVEEGVRIKPITVELDEEGTRISLTIVDTPGFGDQIDNEASFGEISGYLERQYDDILAEESRIKRNPRFRDNRVHALLYFITPTGHGLRELDIELMKRLSPRVNVIPVIGKADSLTPAELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRSLMPFAIVGSEETVEIGGRKVRARQYPWGIVEVENPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVEGGSAAGSSMNPEDLASQSVRLKEEQLRREEEKLREIEVKVQREINEKRQELLARESQLKEIEARMTREASANHADLGQNGDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTY7</accession>
    <name>U4LTY7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Transcriptional activator hap3 acc. no. P36611</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_14265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936032">
        <property type="protein sequence ID" value="CCX33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTY7"/>
    <dbReference type="STRING" id="1076935.U4LTY7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="237" mass="26265" checksum="5934FFC25C4979B3" modified="2013-12-11" version="1">MSSMMTNIAKGIDEVILEETPVEQAKQQLVVHQTQRSQQRLAEEEQRINDYLVHKEQEVLAKEQHIIKYCSHLADQRLAEEKQEEINDYEHYRKLALDPACIPTRSVYNVMKRALPNHALITKEALHAVTRCVEAFIELLTNEAAEIAMNERLKMLLPRHLAEAAELLEMEPYATVFWAIANENEKMPQLQHGGRETILAVGSGSGGVDGDDIADASGGVSGCGIGSGTESPEPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVP1</accession>
    <name>U4LVP1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized protein C1F12.04c acc. no. Q10346</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_04239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936612">
        <property type="protein sequence ID" value="CCX34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVP1"/>
    <dbReference type="STRING" id="1076935.U4LVP1"/>
    <dbReference type="eggNOG" id="ENOG502S1P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLCVHWS"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="28589" checksum="46D18BB8DC2C31AB" modified="2013-12-11" version="1">MSFNKRNPDVFDIVKSQLKLADKKIAHLHRLLQTPAGIDRVLNLLYYLATFTAPQLSRLASDLTVKLPTPIPLFVLTPSSAALNEASVRLRNLSARISDVRMFMRLFGLIGMYQWGKSTLMDPPKDKIMRTLVAGQVIVNTCYQVLENMAYLNKHAVLKFSKRTEGKMWLWSTRCWAAHITLEFLRLERVRMLKGNKGERDYEWIKTWIANAANAPLSLHWSMEKGLIPDTAVGAFGGVAGIIGLTDAWNKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVT3</accession>
    <name>U4LVT3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">deuterolysin</fullName>
            <ecNumber evidence="4">3.4.24.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_04370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="4"/>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVT3"/>
    <dbReference type="STRING" id="1076935.U4LVT3"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21327" checksum="1F3DCA3773F0889C" modified="2013-12-11" version="1">MATSTQVSRSDYISLGVGQSFETTIDLKNICKFPEGEAKFQVKAEGVFEAAPLDSPAIIWEEYKNLLPYQQEKVLEINVGTKQETAEAKVTKRMETVDCIHERPAVLQKALQMVAYRANLTAFEAIHGDPEIFQKYFKTTLRYQHLLVSRNFHKIALEAGPSYGSEVAYSCGDVDAICQTRQDTIPDGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVY4</accession>
    <name>U4LVY4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Protein AIM2 acc. no. P39721</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935934">
        <property type="protein sequence ID" value="CCX32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVY4"/>
    <dbReference type="STRING" id="1076935.U4LVY4"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACAENDP"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="167" mass="18574" checksum="6845077BA7EB0133" modified="2013-12-11" version="1">MAMALIVGKGFLLDMWLARHTPVNTDPIIDNVLKHLEETYSEGKGYKTSHGIRVVGYCFGGKYALRLAARDDVNAVAIAHGTMMAIEDFKMAKKPVTLACAENDPMLADELREAGVKVLQESNVVHEVKTYQNVPHGFSVYGNYSDSHIKSSQEQVFKQFVDFLGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW96</accession>
    <name>U4LW96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to 4-pyridoxolactonase acc. no. Q988B9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_01092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW96"/>
    <dbReference type="STRING" id="1076935.U4LW96"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YMGGDAC"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="290" mass="31763" checksum="CD89F6E9B3020645" modified="2013-12-11" version="1">MPLPASRQGQIYCYVEALSAGHLTLPEHLFISPCPPNSRKTVPSLSFLITHPTSNLLFDLGLRNPQTAYASSIRTHIETRQPLTTTPDVIESLASLSLAPKDIATIILSHIHWDHIGTPSQFPAPSQFVVGPGALALLGTGGGTTGGHSHFEPGLLPADRTLEITEFPEDIGVSNDTLKAKDWFGDGSLYVVDAPGHLQGHINLLVRTEGGWVYLAGDAAHDRRLLMGVKEVAVWENGGCIHSDKEMAVKTIAKIRKLRDLGVEVILAHDKEWEEQNRERIRPEWILAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXS6</accession>
    <name>U4LXS6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_03996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF936572">
        <property type="protein sequence ID" value="CCX34603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXS6"/>
    <dbReference type="STRING" id="1076935.U4LXS6"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX34603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19261" checksum="814D9CBB9507F180" modified="2013-12-11" version="1">MSFQDKAQNLVSQLDKELSKYPALNNLEKQTGAPKVYVVGGVGFIYFFLIFLNFGGQLLTNLAGFLIPGYYSLHALFTMAKVDDTQWLVYWILFGFLNLIESAFSVTYWLPFYYVFKFMLVMWLGLPQFSGAQVVFKSFLQPLLAKQFQQSGSASANLRAKADAVGGDKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LY37</accession>
    <name>U4LY37_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Lymphocyte-specific helicase acc. no. Q60848</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04247</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936618">
        <property type="protein sequence ID" value="CCX34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LY37"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDICEDF"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15566">
        <property type="entry name" value="PHD3_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000114">
        <property type="entry name" value="DNA repair protein rad8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="377"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="748"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="274"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1283" mass="144716" checksum="65C58977649E78F1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTS3</accession>
    <name>U4KTS3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTS3"/>
    <dbReference type="OrthoDB" id="5434210at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650741" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17567" checksum="6B37EB56D27FDC8E" modified="2013-12-11" version="1">MQFTTLLSVLAMTAMAAASPVSPVPISDHPLLEKRASIGCSMKDLWAAPSGSMDGVIKNLINNNPNGQICTWNINARRDNTHGWVTAECDVNDGQHPAVWYHTWGTAHVCRSRKEIGEMARQIYNSCKQGDIVQGWIQDESRGETWVEIGRTPNGCKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTT2</accession>
    <name>U4KTT2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Ankyrin repeat domain-containing protein 17 acc. no. Q99NH0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935200">
        <property type="protein sequence ID" value="CCX04373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTT2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="175" mass="19803" checksum="805F5A49C69D7AAC" modified="2013-12-11" version="1">MSQVLPWFERPGVEMLMSCIMRFQETALMAAASVGDEEIVRLLLSHSPDKIDVNLTVLKDCGRGASGQTALQKALDRGCIGIVRILLERDEIDIYSERKAGALSHLSRRHNCNDILRFCFERSKINTGTRYFMNVIKNATQYKNMDALRHFSISAPVTASRTFKQHCCLPKAIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU13</accession>
    <name>U4KU13_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Cryptic loci regulator 2 acc. no. O13881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU13"/>
    <dbReference type="STRING" id="1076935.U4KU13"/>
    <dbReference type="eggNOG" id="ENOG502SWDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRWYEPW"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="460" mass="50848" checksum="5C6AF020E310E692" modified="2013-12-11" version="1">MSHGSYEEIQISFSDGDVSRHPTNTTKPEPKADGSYDYFEPLGEDSSKGVLYRQKCAAGVIVDYLPAGTEGRQFMFKTLPAGYALFEHVKVNGSNIRKDTYLFGHPNGGRFRSPAEFIPHVKYLAANSPENAHAATPADKICTCKLCGVGGRSGTPIRASGPVSRGKAIPLRAAHPEAARREVAKEERLGERETLGYIFRKGEVVWIWCGKEEFLYSTTKGDTSLWAAAVIVDRPSATAQLLPETPLNTSFDDIVAGNTPWVESLKNCLYTVHLCNSENPEEPGKPISNIPQHFLRPWLARIDDATGEHPSIPRAKEIVKTFNLFDHAFRGILGRWYEPEAVAHWSRPGATEESKLARTEIVRMTENRKQALGWKSIKGIEFMKDEDRREFRKALLANKMKDIAVGGQATPTPSWNPVNASPAKTPIKTSAMAMAVADDLADDEEDEEPAGKRLRVDEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUL9</accession>
    <name>U4KUL9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Apoptosis-inducing factor 2 acc. no. B5FXE5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_03663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUL9"/>
    <dbReference type="STRING" id="1076935.U4KUL9"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEYARAK"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX04772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="373" mass="40536" checksum="0B1B5649C17F4AAA" modified="2013-12-11" version="1">MPEILILGASYTGIPAAHRFLRALPDHKVTLVNPSTDLYWNPAAPRAIAKDHAFSENNDGLFEPFLPAFDAYPKERFEFIQGTATALDPVAKTVTVLADREIVLNYDHLVITTGARTIGDTPFKQLGTTEETRKALAEYQQKIQAAKTIVLSGAGPTGVETTGEIATLFKGQGKKIYLLDPSEGPLPMLKESVREEARKQLESLGVTVLMKTSVTKEADGKLELSNGQVIEADLHIPTYGLIPNTKFVPKEMLDNTRSVKVDKHMRSIEYPNIWAAGDVASVKIKSLLSATPMLDAMTANFISVAQGGEVVKEYKDDMTPMVVPIGGGFAMGTGQMFGWRVLGLLVWLVKGRSYFIGKAKSTALAKEITGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV37</accession>
    <name>U4KV37_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Pathogenesis-related leaf protein 6 acc. no. P04284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV37"/>
    <dbReference type="STRING" id="1076935.U4KV37"/>
    <dbReference type="eggNOG" id="KOG3017">
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        </location>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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                <person name="Marcet-Houben M."/>
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        <source>
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    <accession>U4KXU8</accession>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYI5</accession>
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                <person name="Gabaldon T."/>
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        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="U4KYI5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4429" checksum="0B44C9186BF0208F" modified="2013-12-11" version="1">MMTSVHQSVRNCTKFRCRLIESLKETLSEPLHNQNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYN7</accession>
    <name>U4KYN7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to VMS1 homolog C1827.04 acc. no. O74977</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_03457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935216">
        <property type="protein sequence ID" value="CCX04744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYN7"/>
    <dbReference type="STRING" id="1076935.U4KYN7"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPHIFMC"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="194"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX04744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="588" mass="65100" checksum="EF7F6A0D17240220" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ49</accession>
    <name>U4KZ49_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat and SOCS box protein 3 acc. no. Q9WV72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ49"/>
    <dbReference type="STRING" id="1076935.U4KZ49"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWATHAG"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="17827" checksum="FD4DA4815C04C6B8" modified="2013-12-11" version="1">MGEGANINTKDSNGWTPLHQAAENGYELLVGHLIDHGATIEAITYKGWTPLHLAVSQGHDALAKFLIEKGANIEAMTPEKTTPLQQAIENGHGTIARTLIENGADITKKHSDGWTLLHWAAKHGIEDVVRMLLNVETDVESRNFSYLPALRHAILNGNGVIALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ60</accession>
    <name>U4KZ60_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Double C2-like domain-containing protein alpha acc. no. Q14183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX07000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ60"/>
    <dbReference type="STRING" id="1076935.U4KZ60"/>
    <dbReference type="eggNOG" id="ENOG502S2KW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SRYNFQA"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="543" mass="60704" checksum="388BA65B52230EAB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZN9</accession>
    <name>U4KZN9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol 22-desaturase</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_04756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZN9"/>
    <dbReference type="STRING" id="1076935.U4KZN9"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KCIGLEY"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="540" mass="61926" checksum="1725C4DEF0D82C05" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZW9</accession>
    <name>U4KZW9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Transcription initiation factor TFIID subunit 10 acc. no. Q12030</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_06904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZW9"/>
    <dbReference type="STRING" id="1076935.U4KZW9"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDAANHS"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="25339" checksum="63249E19076A7D9D" modified="2013-12-11" version="1">MSDTSPPIIKTEPQPDSDTEMNLNGIPPAAPITAPANPGAAMVGGPPNPTPATTMNGAPAATPMAAGPSSAGTPGQAPAGQSAGQIKAEQNGEEASLGGAAIAPLLPPARKDRNLREFLDMMDEYAPIIPDAVTDYYLSLSGLQTNDIRLKRLLALATQKFIADIAADAYQYSRIRQNSSNAGGAPGLGAPTGVAAGVTTGGGGGALRPAARPGFGGGGGSGGTAGRTVLTMEDLGSAVGEYGVNTRRPEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0B8</accession>
    <name>U4L0B8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Mitochondrial translation optimization protein 1 acc. no. P53070</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_07242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0B8"/>
    <dbReference type="STRING" id="1076935.U4L0B8"/>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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                <person name="Gabaldon T."/>
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</entry>
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    <accession>U4L177</accession>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 100304</strain>
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    </reference>
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    <dbReference type="STRING" id="1076935.U4L1Y1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF6">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="206" mass="21756" checksum="C6F98CD0AF3ECDE8" modified="2013-12-11" version="1">MNAAEIFDAVRSLSIPAVLAAIKSGSDTSSIREWEGSVLEAAIRPNPLTTSNARNRIPASATQIIIIALLLTNGARHNPSNSPMGSAVTAAAYLEYVDILKALVEAGCSANPPPGRFGTPIIAAAEAGQIAAVKLLLEKGVDPNAISNEGLYRTPLEAAIKMSRSVKPLKVLMDAGAKDYGTVLEDKVKQRLVITFWMLFCVCIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2G0</accession>
    <name>U4L2G0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein ywbO acc. no. P39598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2G0"/>
    <dbReference type="STRING" id="1076935.U4L2G0"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKYAISG"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="213" mass="24057" checksum="66D85343231A4B6D" modified="2013-12-11" version="1">MVNFKIDIVSDTICPWCYVGQKRLFTAIERFQSSNPGSEHTFDIEWHPYQLNPHAPPVSREKREVYEEKFPGQAEAIFARLGAAGAENGIKFSFNGKTGNTRDSHRLIELAKSKGKGNDVVSRLFAAYFENEQDITDHEVLVNSAKETGLDENEVREWLKDSSNGGEQVDKAVLLNRQRRINGVPHFTINGSEVISGAHDPSEFVRTFNKFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L359</accession>
    <name>U4L359_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_09393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L359"/>
    <dbReference type="STRING" id="1076935.U4L359"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CQFANVQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX09800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="468" mass="51924" checksum="1289B303A941BFDA" modified="2013-12-11" version="1">MTYALPQEHKDMLERSLQETDAEVYEIIQREIKRQRENIPLIASENITSRSVYDALGSVMSNKYSEGYPGQRYYGGNEHIDSIELLCQQRALDAFGLSKEKWGVNVQCLSGSPANLQVYQAIMKPHDRLMGLDLPHGGHLSHGYQTPQRKISAVSTYFETMPYRVDEETGIIDYDMLQKTAILYRPKTLVAGTSAYCREIDYKRMREIADSVGAYLMVDMAHISGLVAGGVIKSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSVDAKGKETLYDLENPINFSVFPGHQGGPHNHTITALAAALKQTMTPEYKLYQKQVVSNAKALENALKGLGYTLVSDGTDTHMVLLNLRPQAVDGARIEAVLEAVNIACNKNAIPGDKSALSPGGIRVGTPAATTRGFSEKDFERVAGYVDQCVKLAKKIQSELPKEANKLKDFKQKVFDGVPELAALRQEITEWASTFPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Z5</accession>
    <name>U4L3Z5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C553.01c acc. no. O74939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935331">
        <property type="protein sequence ID" value="CCX07028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="16"/>
            <end position="91"/>
        </location>
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            <end position="128"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07028.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
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        </source>
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        <source>
            <dbReference type="EMBL" id="CCX04920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="130" mass="15022" checksum="3E397D286EABA87B" modified="2013-12-11" version="1">MLNLIRGREFRERISGKWITFIDQKDKGFTFELVAEDSTLILRLPDFDWNEPRGINVHELRLLDVPSNRKNNMVTFSEGALNRLLEVLVEVKADIESICMSNEEEYGGREGGRGWWFMEGEGEREGKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L587</accession>
    <name>U4L587_PYROM</name>
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        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_04797</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2380">
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    </dbReference>
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        <property type="reaction ID" value="UER00962"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PDH_C"/>
    </dbReference>
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        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX05210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="447" mass="50201" checksum="C45CD9FA416C47A5" modified="2013-12-11" version="1">MGEIHLAEPDVAIGIIGMGDMGKMYARRLAAAGWRVNACDRADKFESLKEEFAEIKNVHIYTNGHFVSRQSDYIIYSVEAELIDTVVGLYGPSTKLNAIVGGQTSCKAPEIAAFEKHLPKDVSIISCHSLHGPNVNPRGQPLVIIPHRTSTPSALDLVTRILSCFDSAFVTLTAAEHDRITADTQAVTHAAFLSMGSAWTANHQFPWESKRWSGGIENVKINVTLRIYSNKWHVYAGLAILNPAAQKQIKQYADSVTELFKLILVKDREEFTRRIREAGEFVFGGREEGLLLRDDILDQFSLSGVPKAQRKPNSHLSLLAMVDCWHRCGIVPYDHMICSTPLFRLWLGATEYLFRQPELLDDCIRFALDDESFRSDDLEFTFAARGWSDAVSNGDFNAYRLRFEKPQSYFAPRFPDAIKLGNEMVAKILRKTEEMESRVGSRDGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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    </dbReference>
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            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="819"/>
            <end position="991"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCX11557.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="991" mass="107300" checksum="64FA7EFA032BCA02" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5V8</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX05400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="32" mass="3540" checksum="F406EB0D0BDB635D" modified="2013-12-11" version="1">MTSPHRGGSALRSIPWTTRYLLASGIGNRQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6P9</accession>
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        <name evidence="9" type="ORF">PCON_12214</name>
    </gene>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
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    <dbReference type="eggNOG" id="ENOG502S7S3">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
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    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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    </dbReference>
    <dbReference type="CDD" id="cd01658">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="rpmD_bact"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="82" mass="9189" checksum="307773BBDC6E638E" modified="2013-12-11" version="1">MAFFKITLIRSGIGMTKKQNGVLAALGLRKRMSIVYHAVTPDIAGKIMKVKELVTVSETEFSETKQEIRARRSPPKGWVVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6W6</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05367</name>
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    <organism evidence="3 4">
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935273">
        <property type="protein sequence ID" value="CCX05780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6W6"/>
    <dbReference type="eggNOG" id="ENOG502ST70">
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    </dbReference>
    <dbReference type="OrthoDB" id="4142625at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651093" evidence="2">
        <location>
            <begin position="20"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="466" mass="49294" checksum="301E356E5E97CA01" modified="2013-12-11" version="1">MHLSPLFLLITLLAPTSLSLPAPTNSPSEPDCFYILDGDGTALPVSQAVIVPLVSEAESASHSAHSAQEGKPVIHTADELVEPTGDTTENLKKPVIHLATEHTENTENTDSNVASDKKPVIHTTDESSSPSSSTENPVIHTTTSNTTGDIPPPPGFIIQPKIGTAPKSPGGKILKQRFGPYVIPGGGKVGEYTDVPSPCPEGGCYITALESSLEYESGAEANIDTGAWLHHMVLVLYGKGRQDLVCGENPFGELQPIFASGNERATARLDNTHPAGIHLRANDTLALSTELMNQSPILKQVWLTVTLEYTFSPGYQAAELIWLDAAGCFGSDVPAKEGAYELRSKPWVWTGAKGGKGKKALRLLGGGGHVHDGGEQVTILKNNATICDSVQLYGRTSAYRESTQSSPSSSSSGSAHHHKRDGGLSHTAMQHISDSGRCSEAAMGIIKPGDMLQAGIANIYVTEINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L750</accession>
    <name>U4L750_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935791">
        <property type="protein sequence ID" value="CCX13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L750"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2440" checksum="60E33BBFC602D265" modified="2013-12-11" version="1">MRLRCMAQKVEPQSIIPLGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4L778</accession>
    <name>U4L778_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized MFS-type transporter C1683.03c acc. no. Q9P6J7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_05472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935275">
        <property type="protein sequence ID" value="CCX05885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L778"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MGTAFMP"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="557" mass="60342" checksum="C044DC6686202052" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7W3</accession>
    <name>U4L7W3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7W3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="26109" checksum="F91C946372191A09" modified="2013-12-11" version="1">MRFTTRTERRASSFFSTCRFSGFCILIHFLALLYPLTLPIACYARLLTSLTSPRSVYLSLNSANKLPKDTRHENPRLLLLTNPNLLHRLEVAGIHSEIFQIFSWLREKTLPVPSSGYRAQKNKPPPRKPPTFLSTDAEIESLAVSWLRKRFFSEKRLPVFDLHQTLSNHPSISLPGLVLRLATQHRTPTCFPFPFRCKPIELGSTTMTPDSIIHRMIFFVRDDSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4L815</accession>
    <name>U4L815_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="14" mass="1724" checksum="936726ADE0A847BA" modified="2013-12-11" version="1">MTEIQTDCWHSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L847</accession>
    <name>U4L847_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L847"/>
    <dbReference type="STRING" id="1076935.U4L847"/>
    <dbReference type="eggNOG" id="ENOG502S1YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2440523at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF2">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="95"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="320" mass="34963" checksum="67DD85DBE6A1F414" modified="2013-12-11" version="1">MPTHRQRAAQAASDTRSQFAQVPYLSGTEPEGFLYQGSQPLPLLPRGVGYQLRSAVMEGDPFDIAIDWQNYSFPAPPGATCAGQKAPPVYRDSIINEKMTNRILVLNTANEKKPGGDWEGGFLGLGAEESLARRSNLVQTLHPQFYPLYDRGGIYSPGVIVFKGGHEQDYLNWETPRWTCVSVVSVAAVRRPKTDETGTRYSFSEERDLQKEKMKTILRIAALNGHINLVLGGFGSCGPGTGSGDGNYPGSGNTTSPSRSTSIALSGTSSSYKNPIKDVCKLWKELLIDSEEFQGYFKNIVFAVGGGENGGQKEFRKYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8F2</accession>
    <name>U4L8F2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935288">
        <property type="protein sequence ID" value="CCX06424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8F2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6722" checksum="1B953C015A5A09AA" modified="2013-12-11" version="1">MLVVSVDFVEIADTLRETPTDTRKAVKKAQVALDCFEEAASETHLTRQKHCTRRVYAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8U4</accession>
    <name>U4L8U4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Probable ubiquitin-conjugating enzyme E2 25 acc. no. Q9LUQ5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_12860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935793">
        <property type="protein sequence ID" value="CCX13267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4L8U4"/>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSWATIQ"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057733">
        <property type="entry name" value="UBE2O-like_SH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23043">
        <property type="entry name" value="SH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="895"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX13267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1160" mass="126792" checksum="85A3A164918BAFDE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9U4</accession>
    <name>U4L9U4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to WD repeat-containing protein 26 acc. no. Q5SP67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9U4"/>
    <dbReference type="STRING" id="1076935.U4L9U4"/>
    <dbReference type="eggNOG" id="KOG0293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="582" mass="65560" checksum="85D54E820F450FE7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA77</accession>
    <name>U4LA77_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936105">
        <property type="protein sequence ID" value="CCX14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651259" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="7179" checksum="6205DF1D95A37725" modified="2013-12-11" version="1">MKLLYIIIPLIVAVAAISDPAPDADPESLQARDQDCNKRCRYNRDCCRGYYCDNYRCRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA90</accession>
    <name>U4LA90_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA90"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18416" checksum="ADC6D48A8B435E73" modified="2013-12-11" version="1">MSKQPKKNFLIYPPAMASAKDIIVNDYLADPVEDMAPDLSDPEEYSREPEGEDEIDLDFDPKAFPPAFVNKCMNSSCPYWRKPFSNGISCPNEACVPFNAEIDNLAAENPSMGEKGRRVEKPFPQERVNITMLNGGFGGAFYDKPEEDGKQATKKMKKGKGKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAQ2</accession>
    <name>U4LAQ2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PCON_03146</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 100304</strain>
            <tissue evidence="25">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAQ2"/>
    <dbReference type="STRING" id="1076935.U4LAQ2"/>
    <dbReference type="eggNOG" id="KOG1133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTHQFRD"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="5"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936576">
        <property type="protein sequence ID" value="CCX17128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD03"/>
    <dbReference type="OrthoDB" id="10348855at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX17128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="373" mass="41823" checksum="6BE8D2282DA1ECBC" modified="2013-12-11" version="1">MRPSTTLQSLALYRFYHLRTARGSRAVTNLIKEIGVRGIVQRETNPAHVLVSAENDSDGRRRMADFRKQIRDMEIPGCRDLPFHETFEVKIPVGCYGVEDNAGLVRDVRQLANEEVAAWVNKCINGPPIRHLLDSVERIQVNTDDRGPRSLIRKHFALAKEPRNVPIRRLNSSPQFPYNVAPEVSENGETSNSINNAANNESTSDERKPSDITRPSDLPKPSDIPKPFNMRPSDETNPSDVKQPVVTKYCRDVSAEPRSGPNPNIIHPQPRPAGTPKIIHENVPDKQDSKKPMGRFRDSDTGYRSLFGKPVDRPLINSNAPFVSKSLFTGVVSGPSPVTAETTFYRSVFKKKFARSDKEQPKAEQPKTEESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD73</accession>
    <name>U4LD73_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Carbon catabolite repression protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin thioesterase creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-hydrolyzing enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin-specific-processing protease creB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_08091</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="HF935417">
        <property type="protein sequence ID" value="CCX08498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD73"/>
    <dbReference type="STRING" id="1076935.U4LD73"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="68"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="569"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="741"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX08498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="840" mass="92556" checksum="C4F48FC5EDF0EEF5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD85</accession>
    <name>U4LD85_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to putative Heat shock 70 kDa protein 12A [Glarea lozoyensis 74030] acc. no. EHL02286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936658">
        <property type="protein sequence ID" value="CCX17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD85"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX17467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="14799" checksum="9D9317BBCA39A953" modified="2013-12-11" version="1">MMRSKRVYKCELNGKYWVDDSLTWSLEKDMVIGNTATTTFSLYQELREPISTRDLIFDDKILICRENKAPDFIWRDDSLIKRLCTLSTDVSYISHERFERKISPRGVHYYIVSYKVRMTLLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDH1</accession>
    <name>U4LDH1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDH1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="33" mass="3882" checksum="228FF7251CE23DBA" modified="2013-12-11" version="1">MSERHVRELSEDGERIRGAGPWWELEYAIKPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDV6</accession>
    <name>U4LDV6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
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        </source>
    </evidence>
    <sequence length="373" mass="41616" checksum="F9492DAFFE3AEEE8" modified="2013-12-11" version="1">MSLTKDVFDIKQHIINAAHIREFPRATTSGYLNLPPLKIVINQYVPKNYTAKTGDISIIFCHANGFHKELYEPFFCDLVVSLRSQGVGIRGIWAPDAAHQGASGVLNEKVLGDHPCWNDLPRDVLHLVNTFAEQLPPPLIGMGHSYGGHAIVKASLMHPSLFTAAVLVDPVIEEHKVFQGSDPAKASSRRRDTWASREEAEGYFRSRAFYKQWDPRCLELHMKHGLRELPTHTYPDKTGFTLTTTKHQEVFTFLKNDGPVGEEFAGPVAAAGDTFRKLHEVVVPVLYIVGGDSPVSTPISNKRKMERTRGAEMISIPGTGHLVPLEKPTESADVAAPYLKKHVENWKSEAEKDRVTPRAMLMPKRFIDSISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LER2</accession>
    <name>U4LER2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Probable rhamnogalacturonate lyase C acc. no. Q5B5P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LER2"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTPEFGI"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="297" mass="33683" checksum="856CE0C58CB7E4AB" modified="2013-12-11" version="1">MAAPTDFTRTVRIVAVSDTHNDIPRPDQIPDGDIFIHAGDMTDDGTYTELKAQYDWIAALPHEVKVVIGGNHDLTLDPFHSKTTRENHFKAKNLFTSIEAQSNGIHYLDTEVRYITLRGGHKEGSKRPITIPIYGNPHQPQWLATDYSFTYKPYPSPESELPWENAPNRTQNVPIWVMHGGPQGRLDQINIPPLQGCVVEAQKIYEARPLLCVYGHFHVAYGVEHVEYEHDKDVVKTATVITKPEDPRYDFSKKSGKALKPGKETIFANVAWMTGLKRQVPERNKPVVIDLELPYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEU1</accession>
    <name>U4LEU1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to NAD(P)H azoreductase acc. no. Q8KU07</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEU1"/>
    <dbReference type="STRING" id="1076935.U4LEU1"/>
    <dbReference type="eggNOG" id="ENOG502QWD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GADTMCL"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="329" mass="36235" checksum="A047893FA4B55398" modified="2013-12-11" version="1">MPKNIIITCAEGQTGHLIAEQILTNDQFSQDVSVHLFSCNPEHPHVQELAKMGDHVNVVECTPGDPKKLEQQFKDSGADGIVLIPPSVDNKLECVEEMAMATKGAGIQSVVLISAAGCDVAEKDKQPRVREFIEIEHMMMKMKGEPETGDAGHSQAIIRAGFYAENLLLYNKYAKDKGKLPLPIGDKHKFAPIALGDIALLAAHTITSEGEHGLGDHVRGQLMTLTGDEGPMMTAGEELADAASQGLGTNMEYEDISEEDAVELLKEAEISESEKEYLLQYYSLVREGKLNYISTHCFHDVLGEHPMEMTDFFKSYAEEFKPKKRKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF68</accession>
    <name>U4LF68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_08289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502STSZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1978"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2291"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="950"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2033"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2107"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1845"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2107"/>
            <end position="2119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2389" mass="270646" checksum="3C70953FD539D8E7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFB5</accession>
    <name>U4LFB5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935519">
        <property type="protein sequence ID" value="CCX10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFB5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="24" mass="2824" checksum="C145F60FC538F571" modified="2013-12-11" version="1">MHVHRRSRNTQFEINIIGDLVNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFU1</accession>
    <name>U4LFU1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935505">
        <property type="protein sequence ID" value="CCX30974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFU1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14341" checksum="997ACBA23C5B43F9" modified="2013-12-11" version="1">MFHYTLLRTTRAGAQSMLHHHITEPPCDRAPAMNHSGDCEDKNKDAAHSQLVFDGPSDERRHGRVPEGRREIGCRVCGVGVAGQEGEVERDWMRCGFEVWTRYVDSTLEISREFVRKHALRVIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFV6</accession>
    <name>U4LFV6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein YGR266W acc. no. P53326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFV6"/>
    <dbReference type="STRING" id="1076935.U4LFV6"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDHRYMP"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="387"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="647"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="899" mass="101248" checksum="D59F3CE2B63576E1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGH5</accession>
    <name>U4LGH5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_10337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGH5"/>
    <dbReference type="STRING" id="1076935.U4LGH5"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="238" mass="26620" checksum="36E0061B92127348" modified="2013-12-11" version="1">MSNLHNPASPFVPFSPNPAIQSGVASPTTPLSISQKTPQLGSSNLRYASSRKSIYDRHLNRTQRSELSKASFAFLFGEMIQYAQKQVSGIQDLEKKLNIQGYSIGQRLLELLLHREGRSAKRETRVLGILQFVAQTVYRHLFGKPADGLEKSRDNEDEYMLIDNDPAVNSYISVPREMSQLNCAAFVAGIIEAVLDGSLFPSRVTAHSVPTEQYPMKTVFLIKFDESVLERESVMPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGJ5</accession>
    <name>U4LGJ5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to MOSC domain-containing protein 1, mitochondrial acc. no. Q5VT66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGJ5"/>
    <dbReference type="STRING" id="1076935.U4LGJ5"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHFPEMA"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="130"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="457" mass="51314" checksum="5F1FD5880060F794" modified="2013-12-11" version="1">MYISSLYIHPIKSLLPIAINETSVNTLGFPHDRTFALLRQSTGQTLHIGQVSQLCLFSVELDGSEALIVRFNPTGDTLRLPLVPKLGREIEVRMHNSPCTSFHVSDAADSFFSQHLGFEATLVFLGNSSRDVLGNVAPPPSGIWSLLGYKPEGKITFADCAPLLVTTSASLEEVSKRCGEGVDVRKFRPNVVVSPDSDDEEEMAAFEEDYWAGLEMGEGVNIELTANCARCSSVNVDFSTGGLVEKEKQPLKMMQKDRRVDPGMKYSPVFGRYGFLGAARGDKELFLKVGDKVKITQKNKERTEFCKFPVPCVEICVDFWNRLAGTIDCFMMLTATMNQLIEDTEREIAQLQEKLQLLHERAAQKTTFETQEQQTPTPQISDRPKSVITECRCARKVSKQTDPLVRVREDQKRRIIATGKSLYSINKEIEFFLTDRENSFNFISKPFGEHKPSVTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGV5</accession>
    <name>U4LGV5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Chromodomain helicase hrp3 acc. no. O14139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_10038</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935541">
        <property type="protein sequence ID" value="CCX31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LGV5"/>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVQIRDD"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17993">
        <property type="entry name" value="DEXHc_CHD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="309"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="411"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="509"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="811"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1337"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1371"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1480"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1523"/>
            <end position="1538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX31148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1641" mass="189657" checksum="5A28C54188DA0B8F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHB7</accession>
    <name>U4LHB7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LHB7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="58" mass="6417" checksum="4AA9144DDDAEA454" modified="2013-12-11" version="1">MVPQVILPTEPVFPPSITILDVAVIQYTVFIMNLTDMTTQRLDVATTVSTKVVWVIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHE0</accession>
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            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">PCON_10611</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935585">
        <property type="protein sequence ID" value="CCX31328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LHE0"/>
    <dbReference type="eggNOG" id="ENOG502RYRY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGWNYTN"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652308" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="262" mass="28103" checksum="05A5DEDE27B96E81" modified="2013-12-11" version="1">MRSSFFTAFALLALSSFSVATPHQDIVQRDALVPRQNVARPTAGEGDAIVGDSSPISSAEAPSETGKVTGSGKASGSGKPASKTVKIPTDAQVGGITIITPNVYEQFPFYKDTDFITFEWNYTSVIVTPTALNVVAYAANNDYTIAANISAQQTRVVWDVSAYNAKATMRTPSEKYTLKIWDASKPSNAAPSPGYLAPYAGSPFGIYQPKPYVPFESYVCISCPPDKNDANTDRALAGMGIMGIITASSFVWFITHRFARLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHF9</accession>
    <name>U4LHF9_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHF9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11341" checksum="5B4E1B4C0CF654E5" modified="2013-12-11" version="1">MNPKKDQFARNTISINNAAGQQVNTTHAASTTLLTGVAPPASTVPVTSATIPTIRLPTYRTIPNGWTKRCILNVCNLTVGLMFMEHDPMHRQYAIDTAKELCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI03</accession>
    <name>U4LI03_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935604">
        <property type="protein sequence ID" value="CCX31558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LI03"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3607" checksum="DACF68A01F8DF337" modified="2013-12-11" version="1">MEMLGIRYEGLSSHLNRKLKVLTDTEDRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIK3</accession>
    <name>U4LIK3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Putative sterigmatocystin biosynthesis monooxygenase stcW acc. no. Q00730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIK3"/>
    <dbReference type="STRING" id="1076935.U4LIK3"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKGCHAW"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF11">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="595" mass="67531" checksum="1B074218C41670A8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIQ9</accession>
    <name>U4LIQ9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIQ9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="31" mass="3516" checksum="9FF992C09162C14D" modified="2013-12-11" version="1">MKIHIPHPTSAHHHGLLCRIMPVACLYRVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ33</accession>
    <name>U4LJ33_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Golgi pH regulator B acc. no. P0CG08</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935615">
        <property type="protein sequence ID" value="CCX31577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ33"/>
    <dbReference type="eggNOG" id="KOG2417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSVYCVY"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="7">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="6">
        <location>
            <begin position="309"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="511" mass="55522" checksum="A725889FB631E132" modified="2013-12-11" version="1">MAILPSPAADEKCDDLCRPPSASTSGTLPLPHLLSCLPFILTFSLVSILVLHRLFPALCGPRQPTESRTRKRLSALAFSTTLGSTAVLAELILCEVSDWVAADARKFAFRVTIHVLLICLIIAIPLLELYSLVENKWSKGRRSLAVITAFGGWVWLFWNLPIVKGHMGVWASGERTVSEECLARVGVVGVSLMALLSGFGCVSTPWQNFGAKEKTVSDNDIARTSAGLDATSELLITKTNKLRYLERKISEKGPANEGIMSKVFSAVRGGDADTTEKAVLIKEISGLETMRTSLAAELADFQRRLTTQQRAKSLTGRILKTMSWGFSIYCLYRIAATTIAHLPIIQRRRSSFSQSDPINNILALLAVYWDPHLDRAAWSRQIGFLLSGVIIAGSLGSVMTTVNMLMRVAPGAINSDNNPNLPLFVSQLSAVYVLASALLLRSNLPASMSTVLSESLGAPLDPKFVDMWFDSLFLGAAATTAVVIVVLRRIRKGEERDLENGMGTGVGTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ68</accession>
    <name>U4LJ68_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankyrin repeat-containing protein DDB_G0279043 acc. no. B0G124</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_12088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ68"/>
    <dbReference type="STRING" id="1076935.U4LJ68"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="263" mass="29647" checksum="D259E39CDACDEBD5" modified="2013-12-11" version="1">MASRKRVQPIPNEIILEIGKYCIDPYSVQALSRLSRVNKTFGDLFDEILYKQAADITKMNIERKDKSNIRINNGREIQINNYAIRAVQKNRKKVLERLLDLGVPVNTTAQEYAKRDAYPKSLLHYSVDSATLAKMTEPDTSITALLLDKGAEVNREDNHKCTPLHIAVQHGAPSYEPRPSTDKWVTLLLQRGANPNLTEKDGDTPLHMAAFVNNKTAIPILIKGVNGVKANRNARNEACKTPLQVAEDRFRGDQELHRLLKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ69</accession>
    <name>U4LJ69_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936599">
        <property type="protein sequence ID" value="CCX17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LJ69"/>
    <dbReference type="eggNOG" id="ENOG502QUQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GLRWYLI"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="113"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="962"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1135"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1208"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="641"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="852"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1291" mass="144391" checksum="E4BA407F0CFEE709" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ75</accession>
    <name>U4LJ75_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935704">
        <property type="protein sequence ID" value="CCX12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ75"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6706" checksum="394EE71080ECB698" modified="2013-12-11" version="1">MLNRLPTEILLNIGDLLLNETTSTLHENLSTLRLPEREKCVQPPPPLPESTALIRSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJG7</accession>
    <name>U4LJG7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Acetoacetyl-CoA synthetase acc. no. A3QK15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_14152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935186">
        <property type="protein sequence ID" value="CCX29515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJG7"/>
    <dbReference type="STRING" id="1076935.U4LJG7"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWYREWA"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX29515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="689" mass="76995" checksum="8E608BDC5DCA6081" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJK0</accession>
    <name>U4LJK0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJK0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8292" checksum="FA3B99AA6B86679E" modified="2013-12-11" version="1">MHIELLLYELLMDIGSYGNFNTLANLCAVNKRFNKIFTGQLYKKAAVLAAKGGRVHLNPAGYAIYSNNSWLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJT2</accession>
    <name>U4LJT2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_12486</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HF935726">
        <property type="protein sequence ID" value="CCX12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJT2"/>
    <dbReference type="STRING" id="1076935.U4LJT2"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQFNDFY"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="12"/>
            <end position="264"/>
        </location>
    </feature>
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            <begin position="347"/>
            <end position="906"/>
        </location>
    </feature>
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            <end position="1015"/>
        </location>
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            <end position="400"/>
        </location>
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            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
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            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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            <end position="515"/>
        </location>
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            <end position="553"/>
        </location>
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        </location>
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            <end position="638"/>
        </location>
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            <begin position="643"/>
            <end position="661"/>
        </location>
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        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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            <end position="715"/>
        </location>
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        <location>
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            <end position="741"/>
        </location>
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            <end position="755"/>
        </location>
    </feature>
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        <location>
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            <end position="792"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="41"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117097" checksum="E7E54DC4ABE85924" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJU7</accession>
    <name>U4LJU7_PYROM</name>
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        <submittedName>
            <fullName evidence="8">Similar to High-affinity nicotinic acid transporter acc. no. P53322</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PCON_11456</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="283"/>
            <end position="303"/>
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            <end position="335"/>
        </location>
    </feature>
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        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
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            <begin position="368"/>
            <end position="392"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX31812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="496" mass="55399" checksum="D8FD7F3C4BD7E52C" modified="2013-12-11" version="1">MEDHSSVDDKVDVKSQDIEDPDAGLSFEEREKIDRDLVRRLDYKLIPWLCLLYLFNFLDRTNIGNAKIEGLIDDLHMTQGQYNACLSIFFVACVVFEPISNTLLKLMRPSIYIPIIVTICGLCMLGMGFCKNYPQMMVARMFLGLAEAGLYPGVNYYLSCWYKRRELGIRAAIFFSAAAVSGSFGGLLAAAISQMNGVAGLRGWAWIFIIEGLATVVIGFISFWMVHDFPDDAKFLNEQDRQRVLRRLRDDQQSSGGASASEDFKMEYFWQSVKDWKTWTGSVIYMGVDGALYAFALFLPSIIKDLGYSTTRAQLLSVPPYAAACILTIVVGLWSDRTNKRGIYNICTSVIGVVGFCILLGSKGRNPALSYVATFLGALGIYPAICNTITWVSNNVEGVYKRGVTLGFVIGWGNLNGIVAANVYPVKDAPHYTLGHSIVVGYLTIGLFGGSVLNYYLLNRENNKRRNGERDHWVKGKTAKEIEMMGDMRPDFLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJZ6</accession>
    <name>U4LJZ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RNA polymerase II-associated protein 3 acc. no. Q5ZKQ3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJZ6"/>
    <dbReference type="STRING" id="1076935.U4LJZ6"/>
    <dbReference type="eggNOG" id="ENOG502S1W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="902" mass="102296" checksum="190A4BA8AFFEF5D3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKA3</accession>
    <name>U4LKA3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Uncharacterized transporter C1002.16c acc. no. Q9US44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_12097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935718">
        <property type="protein sequence ID" value="CCX32002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKA3"/>
    <dbReference type="STRING" id="1076935.U4LKA3"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFTTMMQ"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="486" mass="54344" checksum="0E24AFAC68758AA2" modified="2013-12-11" version="1">MSAEKVAVDHPPASDPETGSNSENAPPLDTRKLLMKLDLRILPVLSLAYLFAFLDRVNIGNAAVFGLSKELNLKGTQYNFALCIFFIPYILLEIPSNALLKKIKPHRFLSGCIFMFGLTTVLQGLVTSYGGLLATRFFLGAFETGLFPGAFYLLSMWYRREESQSRFSFFFISTTLASAFGGLLASAIGKMDGVRGMLAWRWIFILEGTMTCVFAIGSYFTIPDFPEDVKWLNEQEREWVITRLRGDVGSSGRETPAVKWKDLKVIFTDYKYILGAVMYLGFIVPAYGFSYFAPTIIKGWNYTPIEAQLRTVPVAMVAWVLAMATAYASDWMKHRYWFIIFCSSITVIGFAVLMTTHGNRAVQYGGLFMSYPGAFSAMPLVVCYFQTNLAGHTRRSIGSAFQISFGNLGGVIATFIFLAKDGPYYVTGYSVCIAFTILTMVTSTFYVIGIRRENKLREAGLAGIVVENEEDEGEIGDMSRKFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLC0</accession>
    <name>U4LLC0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Lysine-specific histone demethylase 1A acc. no. O60341</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_08262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLC0"/>
    <dbReference type="STRING" id="1076935.U4LLC0"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WCAENPF"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SWIRM" evidence="6">
        <location>
            <begin position="260"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX30160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1155" mass="127422" checksum="8A9812682281CEC1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMJ9</accession>
    <name>U4LMJ9_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_08774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4512" checksum="3238C243B00EE352" modified="2013-12-11" version="1">MCLSPLLGNRCRSIRVITYVYFIARHLPHQQNPAPPCDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNX4</accession>
    <name>U4LNX4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Transcription factor TFIIIB component B&amp;apos acc. no. O94481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2009">
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    </dbReference>
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    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="423"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="592" mass="64492" checksum="F164D7D8EB7660F5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPM1</accession>
    <name>U4LPM1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936249">
        <property type="protein sequence ID" value="CCX33885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPM1"/>
    <dbReference type="STRING" id="1076935.U4LPM1"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14922" checksum="A466488AD2D384F0" modified="2013-12-11" version="1">MEPISAMSSVVGIIGIAGQLTSYLSNFITTANRASALAQHAFSEITNLSMMFSQLQGFLANQQPSQSRAMITVDELVVILTGCSVIFLELEKELRGPSNSKEMGVWEAVKWAMKESTLKRYSTNLASIKRHLIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPP7</accession>
    <name>U4LPP7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935561">
        <property type="protein sequence ID" value="CCX31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPP7"/>
    <dbReference type="eggNOG" id="ENOG502SD8H">
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    </dbReference>
    <dbReference type="OMA" id="SEAIWAQ"/>
    <dbReference type="OrthoDB" id="5411041at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="21841" checksum="E421170ECBF1E3AB" modified="2013-12-11" version="1">MATSSTSSTAPPSGPVGPSPPSMEQLLARQTEYQDLQYKVALGMVILGPILIALPPRKLDHYTFGLGMVWLYTLNEVSKHHGGKTIVERVFAPSSATQEKERSLEQEIKKGWLGESVFAQYREREEEGKGIGEMIMESVWDVWQQRDKRSLTREQEEEEEMPLRERVKKVQEEREKVRERALVEELVKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQL5</accession>
    <name>U4LQL5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_03205</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LR99"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="52" mass="5663" checksum="DE219457E88668FF" modified="2013-12-11" version="1">MRTRSSGKLFPVSCSMWVACLHMKDAQGQGEAPPYAVVRWRLLVGGSAAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRU7</accession>
    <name>U4LRU7_PYROM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PCON_04572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2143"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1933"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2145"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2185"/>
            <end position="2201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2201" mass="242008" checksum="CD8554F493702F41" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS58</accession>
    <name>U4LS58_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Lysine-specific demethylase 8 acc. no. Q8N371</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PCON_03621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34409.1"/>
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    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
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        <property type="entry name" value="Cupin_8"/>
    </dbReference>
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        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="100"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="253" mass="27648" checksum="771CBCA09A63C5D2" modified="2013-12-11" version="1">MLSLPILRPATIATFTPFLAAAKPCFLPRGSLTVPALTTWFTPSTPDSTGGLDVSFFEKTLTPEQLSSLVTIESSTATSFSRSQLPFALFLQYLSAGSPPPGLPHLYLAQSPLLENFPQLKASLPTPELVQAGRGDIYATNLWLGYSRGLVTPIHRDPNGNLFLQMRGRKVVRLWGPEVWTEGEMGGRLLREDGMVAKREIGWGPGSENSGIERGGHEVEVKEGEGLFIPTGWWHTVKGVGEGLSASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTJ3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935497">
        <property type="protein sequence ID" value="CCX30836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1076935.U4LTJ3"/>
    <dbReference type="OMA" id="TNANCAC"/>
    <dbReference type="OrthoDB" id="10675110at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652631" evidence="1">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="473" mass="46606" checksum="72129B6A061B1648" modified="2013-12-11" version="1">MQMQICHSLVMAVVALGGLSQVRAAPMPAPGVPCPCPAPCDRGFDAVAPLARCGCVGPCTCGARPAAVNIVNGGCGCHGPCGCGPAPAAVNIANLGRNCCCPGPCDCGPAEKALGLAADVLNPCNPCGCPSPCACPAPCDPCACPAPCAPPAPCAPAPCAPAPCGPVAVNDTPHIHQEVNLPCGPPCGCPSPCTCGAALAVNQINNCGNCGCPSPCGCPNPCPAPCDPCNKATVASSSASASAIATNANCACPGPCACPPCGCPAPCDCAVIQPNDCAPCIEIPVAAPCAPCNPSVDACADAEACITKRSNSFSVNPPCCGCRGPCGCGPNLLGADLAGFAHKIAPNAFGPHFDAATPNIVAPAPSPCDAPCDPCGPIVVPAPQFQAPCDTTVVEPAINRLNPALVTEHTDIQPVNIVQPFHDVTQPIVDETIQPIHSATVNDPIVQQKVAPCQECGCNPCACGGPFAHGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVH5</accession>
    <name>U4LVH5_PYROM</name>
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        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVH5"/>
    <dbReference type="STRING" id="1076935.U4LVH5"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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    </evidence>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF122">
        <property type="entry name" value="PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="4">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="685"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="968" mass="106703" checksum="BF10A256D0CB1A54" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LX25</accession>
    <name>U4LX25_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_03017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="HF936392">
        <property type="protein sequence ID" value="CCX34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LX25"/>
    <dbReference type="STRING" id="1076935.U4LX25"/>
    <dbReference type="eggNOG" id="KOG0524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="50"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="376" mass="40992" checksum="865C7FA86B09CE5A" modified="2013-12-11" version="1">MVFAPARSVFGRAAMRAAKLPTASAIRVPAIQMSAQLQQKRYSSSGVRDYTVRDALNEALAEELERNEKVFIMGEEVAQYNGAYKVTKGLLDRFGEKRVIDTPITEHGFTGMAVGAALHGLHPVVEFMTWNFAMQAIDQIINSGAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGAIPGLKVVSPWSAEDAKGLMKAAIRDPNPVVVLENELLYGQSFPMSEEAQSNDFVIPIGKAKIERAGTDVTIVTLSRCVGQSLIAAENLKKKYGVECEVINLRSIKPLDVESIVQSVRKTKRLVAVESGYPMFGVASEILALSMEYMFDSLDAPAQRITGAEVPTPYAQGLEALSFPDEDLIEKKIAQLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYD7</accession>
    <name>U4LYD7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_04366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYD7"/>
    <dbReference type="STRING" id="1076935.U4LYD7"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLYFMFA"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="867"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="909"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="924" mass="103823" checksum="B668D36640E3EB40" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUT1</accession>
    <name>U4KUT1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SET domain and MYND-type zinc finger protein 6 acc. no. O94256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_02721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUT1"/>
    <dbReference type="STRING" id="1076935.U4KUT1"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSCDYNS"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX04541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="483" mass="53567" checksum="BF0D1922D3AF8461" modified="2013-12-11" version="1">MTTHTAPSPTSGGTGLFTSVALEAGTEILTIPQPLITLPDDAHLSETCSGCLAWKPAAGRRGVNSYYSAGKELLSCTGCRTVKYCDQVCQRADWKYVHKKECGIFSRLAPRVLPASVRALVRLLLLQPTMSKEDWRKVEERQSHFLEFSNTQKWGEICLMAKGAKMYSGTEMAEAGVLKLYCMMLVNTLTLTTPTLDPIGICFDPLAATANHSCSPNASIIFSGRTLQFRSLDKISNGAEITIPYVDTTFPTKTRREELRLRWFFDCKCSACEEAPRGKTDLYSCPHCSGAVADKEPMICTNCKKSLPGPPSESTDLKTLHKSGYYPITRQPLPFLHSELVQSLLADGNFREALKHQLLLHVSIYPLLYTQSHHPIRVCSGFVLAALLMEVVRDPGEELKKVDVDWGKTLWALLLEIEQGVRRSHGGDSGFAMMVKAKMKEVKEELVRSGVGWLRGDGKVNGLEREWPKVEGVVRGVLKELKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVM1</accession>
    <name>U4KVM1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized membrane protein YMR253C acc. no. Q04835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_05240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935264">
        <property type="protein sequence ID" value="CCX05653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVM1"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PIASCYV"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="95"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="265"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="449" mass="49035" checksum="81FF16CF57B36EFB" modified="2013-12-11" version="1">MFHPRPTHADQAPLLSPTDHGSPTYSRTPSPPSDPPTPGLLSVPSPFLNPPKLGRYPSSPSPAPSPELRLESTSPSPTLLRTLLIRLRARMHTNRGLLLILLAQLFASLMSLTARLLSTGPQRFHALQILFIRQTITAAGCYLWMYLRSTPSAPFGPPEVRWLLIARGLGGFWGVFGLYYSLTYLDLADATVITFLAPIVTGWVCSVIPGLKEPWTKDEAIAGVVSLVGVVAIVRPGAVFGGASPVEGAGQGGGHQVTPEQRLVAVLVALVGVLGASTAYTTIRLIGKRAHPLISVNYFSTWCAIVSLFSLLFIPSVGGFILPQTRKQWLLLGGIGLSGFIMQFCLTKGLQLEKAGRGTNMVYSQMIFALIWERLVWGTSPGFWSMVGSALILGSAVWVGVRKQKETTVISREDEESQREGLLAEEQQQQQERYRDEEENEEILEQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVQ6</accession>
    <name>U4KVQ6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_05290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="HF935266">
        <property type="protein sequence ID" value="CCX05703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVQ6"/>
    <dbReference type="STRING" id="1076935.U4KVQ6"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RRHIYRH"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="298" mass="34472" checksum="469AD79A9BE19FC2" modified="2013-12-11" version="1">MSSTSTVPQEPTEEDQCVICLSPITSPCTACPCNHSYDYLCLLNWLEVRQTCPLCNALVPTIKYLDGATGKEILHLVEPPCPDPPRTEPEPEAAPNFTTGNARIINSRDLPRRRRRYDRPLPPILPDIAILRRRHVYRSNMRCLHVGSNRISRFRDFTPRIVATDDELQSRAKMFIRRELQVFEWLDNENKEFVLEYILAILKTVDLKGAAGTAEDMLADMLGSREYAGVFCHEIHAFLRSPYTELGMWDAWVQYETPLPSQFDSDGIPVEQRESRKRVRDREDVQGNGEQERRQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW09</accession>
    <name>U4KW09_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935238">
        <property type="protein sequence ID" value="CCX05216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW09"/>
    <dbReference type="OrthoDB" id="5490748at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19166" checksum="499F0B0F5DC65738" modified="2013-12-11" version="1">MPSTTATTSANKHGMTLRGRSPKPKPTGTTSTTTHNESNKPNKASKAAKSAKNNKASKVTKNTNTNKAPNNNKADKSKKIMARYIFTLEALQTLRLYKEKSNPQFVEGYLKKLAKQQNAPEKGIEITVSVSEGFEFLGWTKEMVFRDIKFAKEMGMELDDSEFKTKWNDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWA3</accession>
    <name>U4KWA3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Lipase 3 acc. no. P32947</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935268">
        <property type="protein sequence ID" value="CCX05727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWA3"/>
    <dbReference type="STRING" id="1076935.U4KWA3"/>
    <dbReference type="ESTHER" id="pyrom-u4kwa3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WDANIWA"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650792" evidence="1">
        <location>
            <begin position="18"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="52"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="564" mass="62279" checksum="249C218C419BD194" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWF9</accession>
    <name>U4KWF9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_05043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="HF935254">
        <property type="protein sequence ID" value="CCX05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWF9"/>
    <dbReference type="STRING" id="1076935.U4KWF9"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QIPAQKD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="EMBL" id="CCX06417.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="17126" checksum="99BBDF27D70BDFAF" modified="2013-12-11" version="1">MAHLYRQDRSLLTTLHSAQRKENSTSQDSSVKLCTSANSSLEEANVKPKKLAFALPVQDPVKFDFNSTTDAEFDDWVIITKDEVPKDRVKSRGLAMFCPKRTTLDLETTKTPSLDPAEEESDSSNFDVSDYELDDDAPRKRRKSIVDAKPVD</sequence>
</entry>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </source>
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            <begin position="933"/>
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    </evidence>
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</entry>
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                <person name="Gabaldon T."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17970" checksum="305BDE1FEC40A701" modified="2013-12-11" version="1">MDCRPQLIKIGYKSRTEKSWPMGSVDLVEDGKFGPRLVVNSSFVARKPSFICDPMEYTTTLVNNHIVVLTSKDPEAEAQTVALTFQELSEAAQTYYVTLDYFKELEFLSPTINTKHHVNTFQLQRIELNDTTGEQLLLPTPRWNSKLMLYGESYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXK5</accession>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 100304</strain>
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    <dbReference type="AlphaFoldDB" id="U4KXK5"/>
    <dbReference type="eggNOG" id="ENOG502S69P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5364171at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="252" mass="28450" checksum="04DD638901A20230" modified="2013-12-11" version="1">MSVFYAYAITGNELDNRHLITFASRSVADEWWRAIQDSVTERDRTTFAEIKRVTPQLYASKNSWGTILNIVTDTRWTPHLVGKWFFTLLHDFGGGGLCDSLAPPIDITDHISGNCYYIRSKCEPNQYWHLTNQSLPEGAIFGPHQVIRLSATGHTRFCIDIRAANRLPQNGKIMIGSDDIIISALRIEDNDVVINDVCPIGDNGTLVIGVASYVFKFSDFENRFIMSSAINGSQDNHILKLRKIGQKWELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXS8</accession>
    <name>U4KXS8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935285">
        <property type="protein sequence ID" value="CCX06325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="69" mass="7427" checksum="F2E3CD441B682E80" modified="2013-12-11" version="1">MTLLASVDRLPQQRLRRSNQGFPSAMPGDRSQYPGSPGSPGSPRSAGFCHAHSTKMNAAWSLSKTVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXX6</accession>
    <name>U4KXX6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4140 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935313">
        <property type="protein sequence ID" value="CCX06786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXX6"/>
    <dbReference type="STRING" id="1076935.U4KXX6"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="111" mass="12031" checksum="3CE6D4C563349CF3" modified="2013-12-11" version="1">MSKLHTQTISLTNCPTRSITLYPTSALVVRDVPDIVVKPGTNIYTIRHFTRHLVPSSLRISGHGTSSVITDTSTILLSSPPDDEHFDSLASLESSLAAAKPHPKSVDLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY69</accession>
    <name>U4KY69_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TBC domain-containing protein C23D3.03c acc. no. Q09844</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_06498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY69"/>
    <dbReference type="STRING" id="1076935.U4KY69"/>
    <dbReference type="eggNOG" id="KOG2223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSKAIGN"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000034">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="416"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX06911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="681" mass="76676" checksum="E5FC65F854713BD8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYQ6</accession>
    <name>U4KYQ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Kinase D-interacting substrate of 220 kDa acc. no. Q7T163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYQ6"/>
    <dbReference type="STRING" id="1076935.U4KYQ6"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACQYQSF"/>
    <dbReference type="OrthoDB" id="3351993at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="663" mass="75268" checksum="0CD2631830215654" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYT2</accession>
    <name>U4KYT2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYT2"/>
    <dbReference type="STRING" id="1076935.U4KYT2"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="490" mass="56396" checksum="72A836E977BB18F1" modified="2013-12-11" version="1">MEEMNNFITPILEHEAVPRDSWATARYPFYISFGIKKRLYTHDNLSDYTNRRNPLPPHLRHDAQLTFGIELELILDGVVPKDGLNIMNTTLKQLFNSGKLPFDSMIPEEHKKIAPADRNKFMIMPDPSINARLGLKEGVQIPDLNPGWEFVPVEFVPDCGDWGTPELNHWHSKNTATDSDSWGDSQSSVPESYGTEETEITTPDSDPVVIEEVCSEEDDWFAQDTDWVELSPDLPPIKRKEKPLCQEEEKRKWMLAQPEDKCILGAAVEICTPILQQRNVKKTIRTVIEHLDKELKVVHNKSCGLHIHVGRGQGNRWSFEEMKAIAKACFLFEEAVNLKHAPHRREGNRMIRSNRWSTAARDATMLILFEEIDDCDSEWQFLHLVGKEKYFKYNFHTNAQYGTIEFRQAEGHKDSKRIIEWVKFLSYFVTAAINVDQKEWFAWGQLVGYGTIEGLLNLDSAVFKRFGLDKAQVGLGFKELELEIDDTDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ95</accession>
    <name>U4KZ95_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Membrane-anchored ubiquitin-fold protein 3 acc. no. Q6Z8K4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ95"/>
    <dbReference type="STRING" id="1076935.U4KZ95"/>
    <dbReference type="eggNOG" id="ENOG502S95Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPNVVHM"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="176" mass="19012" checksum="4D385560C1A65B16" modified="2013-12-11" version="1">MSDPTPTPTTTTAPAETPVETPSTAPTAPPTVPTGPTGPTSLTITVLVQSGARHNFLLDTAYLDRHAVKAVTEPLDMTVTQLKECIWKDWRDDWDQRPASAQFIKLIQFGAYLQDSSMLKDCRLSLDGANVIHMAIRPAESGADDETQRSTKAGRQSSRERNAEGGSSTGCRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZC6</accession>
    <name>U4KZC6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to 1-aminocyclopropane-1-carboxylate synthase 2 acc. no. Q00379</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_04518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZC6"/>
    <dbReference type="STRING" id="1076935.U4KZC6"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIAQKCL"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="97"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="458" mass="50875" checksum="AA7EADDE60D965A5" modified="2013-12-11" version="1">MATQNHNVSNRVRENIAEAAGLAKLWAVLANLYHAEKNPTGIVNLGIAENALMYPELLDKLNKIVGLDTPNPLSISREVNPQCLQPVEAADLPYGANPAGSQTLRTALANFMTKNFASLHPVKPEHIVVSSGLTSIAEMLAWTLCDEGDGILLGRPFYSAFPNDFYARSKVLTVPVSFGDVDQFSEDCVECYEKAIVDWNKQQEEQGKKGRIRAMMVVNPHNPLGRCYPPETLKAIMALCQKHQIHLLSDEIYALSLYTNPSASDAPGFTSILSLSTSGLIDPSLVHVLYGMSKDFGANGFRLGAFVSQNNIEVLQGMSATANFAWPSSMADKAWAAILNDEEFLGAFIETNKKRLGEQYMRCTQILREHGIQFWDQGNAALFLWLDLRDYLPSDMTPLEGEKWLSQKLIDEGGVFISRSETFYGEHPGWFRIVFSLPDAEEGMRRLVKTLDLQPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZH0</accession>
    <name>U4KZH0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935378">
        <property type="protein sequence ID" value="CCX07875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZH0"/>
    <dbReference type="OrthoDB" id="10625204at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="17315" checksum="FA91D7E69240028A" modified="2013-12-11" version="1">MIFSKVKACKSATELTRHLLSYSTEMNINGQPSNFLQIAGASSVYTTPRSPRSPRSPASVFSDDQSCGGVELPQEDKEANSTSTGSPTPQGLALWQTGASPSQQNLGPVNGERSVVRHRPGFLSQYAFSRYPLSLAIRDYSRIPGFSAYDGPRGPANNSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZK6</accession>
    <name>U4KZK6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZK6"/>
    <dbReference type="STRING" id="1076935.U4KZK6"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEIEYND"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="417" mass="47696" checksum="3484EFD95115F49C" modified="2013-12-11" version="1">MHRLIRLPKMLARSAPGLQRVTCRRNIGFNTAWGPGVPWQIYSKRRIQSTEFESALRIGSVRRFLMPSRKPGDIPSNRARLHTETEVPEAPKFDLDADQKLALEHIKQGRNVFITGAAGSGKSEVIKRAVEYLKSANKVYAVTAPTAFAAKQLQGQTIHRWFGHGKADQGINRILRDCGFRQRFDKESSPMRRIKTIVDGDVLIIDEVSMLHPNLFKIINTCLKFGRSNDLFFGGMQVIVCGDFFQLPPVNNFNATKNCIQCGFQIPDANLTGHKYLETPPKYQSHEAIGLLPERWGRCPNHKCEALFNDSIKYVFQTKEWKEAAFVNVYLKEVHRQTDLDWIEVLNQIRLGNRDEQVIDYLQNLSRKLPENGGITPTRIHTHRKGVDEENQREYDKLGGCEYLFDAYDDAVRSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZM7</accession>
    <name>U4KZM7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935383">
        <property type="protein sequence ID" value="CCX07950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZM7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="22" mass="2341" checksum="33449AD54AE1E2B2" modified="2013-12-11" version="1">MAASLKRTFGFALRTASKLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZQ2</accession>
    <name>U4KZQ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935386">
        <property type="protein sequence ID" value="CCX07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZQ2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651764" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="106" mass="11138" checksum="A6F4DCBC582B0BBF" modified="2013-12-11" version="1">MQFTALLILAFSAAAIAAPAETPAQSTDKCYWRDVGSLKSKKPPQSGVVKGIIGCCKGPGLNSCVKVTPGRNCVKNWATICCPESTGVPYEGGAKGCRTDNYTRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZQ6</accession>
    <name>U4KZQ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cytochrome c oxidase assembly protein COX11, mitochondrial acc. no. P19516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_04776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935235">
        <property type="protein sequence ID" value="CCX05189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZQ6"/>
    <dbReference type="STRING" id="1076935.U4KZQ6"/>
    <dbReference type="eggNOG" id="KOG2540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX05189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="259" mass="29099" checksum="AC413CFEA37AE6FB" modified="2013-12-11" version="1">MANSGRVLPSLLKTQWRNVATKWNGSTGRQANGAFRNVKQQQQFFSSTPLRTAQQLRQAPNYRAQYHKKNADIGYYMLSVTIATLTLSYASVPLYRAICQRTGYGGVPITDQTRFTPDKLVPVQGAKRIRVTFASSVSDVLDWKFTPQQKEVRVLPGETALAFYTATNKSKDDIIGVATYSVSPGQVAPYFSKIQCFCFEEQKLNAGETVDMPVFFFIDPDFLEDPQMKGIDTVTLSYTFFKSKSDENGVIRPLPPKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Y7</accession>
    <name>U4L0Y7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized acyltransferase C428.14 acc. no. O94361</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_07507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935382">
        <property type="protein sequence ID" value="CCX07918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Y7"/>
    <dbReference type="STRING" id="1076935.U4L0Y7"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RMVMIAN"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="127"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX07918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="420" mass="49007" checksum="4FB8A302ACD2EFAF" modified="2013-12-11" version="1">MAETKANGTPMTHDAPSKPDPDYHPGGSVRYNRASQILRVITFNVWFFCCVIVILITQFIGAPLYYLNRKLYYDWMSRTKQSFGVVITTITQWWSPTIIRVTGDRSVRDQIRQAADGSLECHFPERMILIANHQLYSDWLYLWWIAYTARLHGYFYIILKESLKYIPFIGVGMQFYGFIFMARKWEQDKSRMEHRLSKLNAEKEDPMWLLIFPEGTNASSNGRVNSAKYSKKLGIKDLQHQLWPRATGLRFCIEQLKGSVEYLYDCTVHYEGVRRGEFGQDYFTLYSTFFQGRPPKSVNMHWRRFAMKDIPIEDPAEFEAWLRQRWIEKDELLDYYTDNGCFPEDDSAKEESNGEVTGLHQRGVLKGTKATGGDNWKGPVVTEVRISRWTDVAGIFIVIATVALLANVWYKMVLLTKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L180</accession>
    <name>U4L180_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Transmembrane protein DDB_G0273707/DDB_G0273361 acc. no. Q556Z9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L180"/>
    <dbReference type="STRING" id="1076935.U4L180"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="119"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX09617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="348" mass="37242" checksum="6BAFB9738B11DB58" modified="2013-12-11" version="1">MTLTQHLSPRPSPPCSENSTTSSSCTETPPSNPRDPRDTTVSPPPAHQHRPPVPITSDQEPPAIEERWGDFNIDALLLRLCPWLPTDNALHKLPRGISHFLGYRPAQLTQRKSQAPMDIIIWSAAAVGCFMGIAGVTGLTMGMSGKDTGLVGSMGAAAILLFLTPLSPLAQPRNLLLSQLISSLIGLGIGRAIPQHWVGPAVCVALSAIAMLATRTVHPPAGATAVLAYADPRWSFVALVMASTGLLAAVAGGWVNVCGVGGWEGGRWPGVWWWAEERGAKVMTGETTQATPGEKISEEWAEGEEEISIGGRGVQVPVWFELSAEERDVLEGLWDRLKERKRPAPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1M3</accession>
    <name>U4L1M3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Alkaline phosphatase D acc. no. P42251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1M3"/>
    <dbReference type="STRING" id="1076935.U4L1M3"/>
    <dbReference type="eggNOG" id="ENOG502QPM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHGPASF"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX06123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="611" mass="69101" checksum="CFABBB61B4D1E607" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L266</accession>
    <name>U4L266_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="682" mass="72729" checksum="7D69F7826F18CCF1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4K7</accession>
    <name>U4L4K7_PYROM</name>
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        <recommendedName>
            <fullName evidence="6">MFS-type drug efflux transporter P55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_06827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935345">
        <property type="protein sequence ID" value="CCX07238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4K7"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX07238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="155" mass="16070" checksum="F7BFD202A6A36FE1" modified="2013-12-11" version="1">MPIAGGLSDIFGRRHFFIYGALISMTGTIISVCSKSVDGVIVGMTLKGIGGAAGNLAMAAVAEIVPKNQRGRAQAVLELGIMPWVVFDALTGGAMVKYQPGRMLGFRINCWYGTFAAAVFCTMELGAIFNDDPVWIGLMAAPAGGAAAGMLLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4M6</accession>
    <name>U4L4M6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C1840.09 acc. no. O74482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935619">
        <property type="protein sequence ID" value="CCX11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4M6"/>
    <dbReference type="STRING" id="1076935.U4L4M6"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WERADIF"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="276" mass="29765" checksum="807E8E6584F32EC4" modified="2013-12-11" version="1">MSSRTLLVCGGSGFLGSRICKIASSRNWAVTSLSRSGEPNWAAEGSRPEWASKINWKKGDVMNPETYKDSLEGVDAVVHSMGILLEADYKGVLTGKEPVVAGLKKAFDSTRATGENTVRQGHAQMTYETMNRDTAVTLAEEAASQRAKSFLYVSAIDSFFTLPRRYITTKREAESIIAGIGEKNNMRTIFIRPSFLYDASRGFTMPLAGVLGCVSAVNGLFGRKIPLLGAAGYKPLAVEDVAGAAVKALEDENVKGVVDVDGISNLATRVWREGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5H5</accession>
    <name>U4L5H5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935695">
        <property type="protein sequence ID" value="CCX12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5H5"/>
    <dbReference type="OrthoDB" id="10315081at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="472" mass="53850" checksum="9A439F5A77657FDB" modified="2013-12-11" version="1">MPNIDSACTDSGYGQSPVGSAEEERSPHGSGPSADWWAMRPTSTATEIEQADDLIRQKARQCFGQILTTLRDNAHKREPSEKLFRLLKLAPRRDPLQGLRKALRSFPFTPQNIEIMRDLALGDLGRPAMTYIVNMIDMLGITPHEVDCVKLCVRAVLFSREEFDAYVIHHSGSNADSGRPWLLPFVVMGRGSEERRAMMNQWTRQIRSQSSLYEYVNSVLCQMNIPGIDDDVKDALYFLSKYAFPDPKHIPDSRLSEELSATLTRKIMNFFSRDQLPNLKIAKQLVRLVASWETRSNIDKHIRKAIVDHLISPISVVDYWGTAKTRHNPWIALGKALMYAIQSLHDDPIRRDVNVLIDILTWHTSSDKGSMSRTAAQEMLIVFFAQLIYTSQLPDHPEHERLMKIEAMCRRHAYFTDVSLKKKMDEMDLSEIIELRLKSKNKYLGILYGKAGPWPQADEGVHSGRGVRTRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5H9</accession>
    <name>U4L5H9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_07280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
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            <location evidence="1">Nucleolus</location>
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    </comment>
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            <label>2</label>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="129" mass="14487" checksum="E5A38ED62B8AC2FD" modified="2013-12-11" version="1">MSSEMGTPAPEAQRSSREKVSFRFCRECSNMLYPHEDRTTNTLLYRCRTCHNTEPANTYCVFRNNLSSNAGETAGVTTDIGSDPTLPKAVKICPQCGESESVFFQSQQRTEDTKMSLFYVCISCGKVHH</sequence>
</entry>
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        </submittedName>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="45"/>
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        <location>
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        </location>
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        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="632" mass="69858" checksum="5DD37B7C13CA50C1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6W3</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935725">
        <property type="protein sequence ID" value="CCX12854.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6W3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13836" checksum="C666B763F076145C" modified="2013-12-11" version="1">MSQATTRAQMLFTAAEYVASLEAQKRAMQKQAEQKSHNQAQKKTQNETKEKVQKEAQKHVQKQAGAQEDLGPCNQTGLFRRWRIWVVRAIARRHQEKRKECGLFQAFKNWNPCIPVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7C9</accession>
    <name>U4L7C9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7C9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="169" mass="19116" checksum="9147DD6A870A50AB" modified="2013-12-11" version="1">MSPLKTLRPKKRHQRQMLLWRTQEPSTGRFSWKSEARRESKDEIDEPEEDMRGGNSGGRIGLGISKNLGHARNYEECELVVWIGNEGKGVYTIEPLSPRSTSISPFFYRPPHGSLHKIIISAITNIAMFSATSTLIYSTDEDITYTLASVEPAPQDFETQERLAVGGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7T0</accession>
    <name>U4L7T0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935891">
        <property type="protein sequence ID" value="CCX13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7T0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="108" mass="11950" checksum="D6CF77F7BCD25825" modified="2013-12-11" version="1">MKSPTLMRSPTKLSHSPSAVVSLADFTSFTRAGSVSVCPVENPVHPGNKPSTQKPRATVVRFSNDPPRRVVYPEDEPLEPLVECDWEVPRANKRPVLDEDTGLWGIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7W2</accession>
    <name>U4L7W2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7W2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX14236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12509" checksum="3A9BE3F9F382EE4B" modified="2013-12-11" version="1">MALNDKVNELKTLCEGFKGKEGSDEKLLITLTSSYDAVVASLHELFAALPKEVITDSGLFSRDTWNSTLAEVCRLAIENVARNKGANKALEEEINIVKTKDSNLRTVIDAVVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8L8</accession>
    <name>U4L8L8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_12770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935789">
        <property type="protein sequence ID" value="CCX13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8L8"/>
    <dbReference type="STRING" id="1076935.U4L8L8"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MQERHVD"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="216"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="617" mass="70003" checksum="B689839EFF66AA1C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8L9</accession>
    <name>U4L8L9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935493">
        <property type="protein sequence ID" value="CCX09693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8L9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651740" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="17661" checksum="8C847531A9731E2B" modified="2013-12-11" version="1">MNPTLTLLAVLFATPSLVFSDEMVPVSFMLNDKTPGIRVSTGDIAIKPLNYCSDLTKSAAVLYGASYHEKTGEKVENPRRVCGYTIKNGCCAFFRDQECKTWAFTSDSSNVRDHKEDDKFRSIICDKQCHVIGKSGKNSAFARDGSEQWHRILAADGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L967</accession>
    <name>U4L967_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Zinc-regulated transporter 2 acc. no. Q12436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_09704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935513">
        <property type="protein sequence ID" value="CCX10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L967"/>
    <dbReference type="STRING" id="1076935.U4L967"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CWVEGII"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="418" mass="44511" checksum="5A2D9348017C4D88" modified="2013-12-11" version="1">MDMISTLIRRDNGTADAPPPACPEANTYNGKFGIRVASIFVIAFAATLGALLPKLLPKLLSKVTCVNIRPNGLFFFFLKYFGSGVIVATAFIHLLAPSTESFGNACLQNTVISNYPWTMAIALFSLFTIFGIDLVSHKKLMARRDVDAEAGQAVELRPVSNGSDGTEYTDQKEPDVQEQANPEDAEDPEVAPAAPAEEAPQNEPRNPVPAEAVPASDPEPANPAVAPANPAVSPENPAVAPAVPAAPALQPYFSNLASLAILEFGIVFHSILIGVTLAVTEVKGLASLFIVLTFHQLFEGLGLGSRLATHQWKRGAKWWSVHSPYVWACGFGLSTPIGTAIGIGVRHSFNQNGKAILIVQGFFDAFSAGILLYTGLVELIAKDVLQGELNNVADGRPMLAFFTMVFGAGLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9A3</accession>
    <name>U4L9A3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936206">
        <property type="protein sequence ID" value="CCX15577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9A3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="6783" checksum="0CA850442D51DB7D" modified="2013-12-11" version="1">MEDKTRPYPYHLLSPPARSQTHRRPPNLSVPNSPSGPVLAQDGTGPKLPSGPVQETGLISLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9D3</accession>
    <name>U4L9D3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to LSM domain-containing protein 1-A acc. no. Q6GQ67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_01296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936128">
        <property type="protein sequence ID" value="CCX15032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9D3"/>
    <dbReference type="STRING" id="1076935.U4L9D3"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEYRHPT"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX15032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="132" mass="14537" checksum="75478067049DEE91" modified="2013-12-11" version="1">MAQTQQPYETPSPFLQGYINRTLRVTTTDDRFFIGDLKCTDRDRNLILASTSEYRSPSSFSSSSSSSSSSSQSPEIKDRHIGLVVIPGNVITKIEVEERTTGTGTNPKRGWMFGQFGSPGGGQRDPREMGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9K7</accession>
    <name>U4L9K7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Proteasome component C5 acc. no. P23724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_13832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9K7"/>
    <dbReference type="STRING" id="1076935.U4L9K7"/>
    <dbReference type="eggNOG" id="KOG0179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="260" mass="28827" checksum="34DE55376264FB4F" modified="2013-12-11" version="1">MSFLATPSYPQQNVPGGEPTQRHGFNPYADNGGSIIGIAGDDFLIMAGDTRHTAGYNINSRTERKVYRLGEESSLVLATVGFGADAKWLADTMKRAVDVCFPRLSMMKDFKFQHNLKDMTVSAAAQFLFTILYGNRFFPKYAYCILGGLDKNGKARLFSYDPVGSYSKEGERRAAAGAASSLIVPFLDNQVEFKNQYVPGTQGMTERPVEYLPLEKVEMLVKDAFTSATERHIEVGDGLQMVIVSAQHGVREEIIELKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAN1</accession>
    <name>U4LAN1_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Similar to Ankyrin-2 acc. no. Q01484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAN1"/>
    <dbReference type="STRING" id="1076935.U4LAN1"/>
    <dbReference type="OrthoDB" id="76949at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37810" checksum="09427E2AD38B9A85" modified="2013-12-11" version="1">MLLPSTIAFNMTSTPSIKFTISSSRETPASITSLPPELLSAILLYLTPLDISHLCRVNRPFRRYFTPPLYRLGVSLCHSDSHLTPIEATIIYNNLPALRRLVRYGVPVDDGLLEFAIKIYGGPLPGRGDGRRRGKRGKGRMRRDGKKVIKFLLNQIPARLPDAKSPVHTASTVSSFRDKESEYEVTRHPGSPEKKMLDASYNRVRSFNALLWVCGEGRREDPGLVRLLLSRGGDIGARDKAGNGVLHLAAMRGWGRVLRVVLEWDRRMKLGKRGRLDVNMENDEGMTPLLLGMERGCKESVKVLREFGAVEDGGMARLLLFLLVGSWCFVGTGLRRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAZ8</accession>
    <name>U4LAZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Ankyrin-1 acc. no. P16157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935594">
        <property type="protein sequence ID" value="CCX11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LAZ8"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1261"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1330"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1395"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1642"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1676"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1712"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1843"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1879"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="2122"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="839"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2344"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2344"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2383"/>
            <end position="2393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2405" mass="268400" checksum="3BA6A2148E676EA9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB26</accession>
    <name>U4LB26_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Protein PLANT CADMIUM RESISTANCE 7 acc. no. Q9LS43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB26"/>
    <dbReference type="STRING" id="1076935.U4LB26"/>
    <dbReference type="eggNOG" id="ENOG502SF2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TLMQHEK"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="132" mass="15133" checksum="9B25B0D5DDFFF2F7" modified="2013-12-11" version="1">MTDKWENSLFSCFSNMNTCMMATFCPCILFGRTRYRLRHPSLDGHNCCNFACFTQCICISTPISCIQRMMQRKEIREKHNLEGGCCGDCMKSCFCSCCELAQEENEVLMKQSKAQEQVGYIKPQGMVYVPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB69</accession>
    <name>U4LB69_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Transmembrane protein 42 acc. no. Q69YG0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB69"/>
    <dbReference type="STRING" id="1076935.U4LB69"/>
    <dbReference type="eggNOG" id="ENOG502S96H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VNAQWLI"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651207" evidence="3">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX07414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="20297" checksum="2D550D61F14058DF" modified="2013-12-11" version="1">MNWVPLALLSGLCAATNGLFAKLTTTALTTSIAHSIAGFLGLESQAGVEVVVRGVFFVLNLVFNAIMWTLFTAALSRGNSATTVSVINTTSNFLAAAMFGFYFFGEALPGSWWIGAGMLIAGSVVISRRDVMKKKEEGYTKLGGGEDGMERGRQRDDDDDDDDEDGGVGLSSSREPSADGADVQNVKLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB74</accession>
    <name>U4LB74_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB74"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9218" checksum="F0C5F82BF810616B" modified="2013-12-11" version="1">MYEWLRCTGKTITVSESGGTMDLAKTLWSGRGSNWRNGIKSLNVYTALWGHGFLLVGFCYFNKFLWHHRLFTQISAVEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB92</accession>
    <name>U4LB92_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to J protein JJJ1 acc. no. P53863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB92"/>
    <dbReference type="STRING" id="1076935.U4LB92"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="920"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX16467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="983" mass="107137" checksum="A07038A468E86979" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC01</accession>
    <name>U4LC01_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC01"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="10297" checksum="3AB0D48EB3FFB083" modified="2013-12-11" version="1">MARFARHHLYLLHQGTPDLPSSSNVLLNFSSPSPQFCSIYFPKFTEIYVTHVELRNFSSVRVYEIPKNLLLKLVKHHVAIMSKSRGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC12</accession>
    <name>U4LC12_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_06300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935309">
        <property type="protein sequence ID" value="CCX29639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC12"/>
    <dbReference type="OrthoDB" id="10310220at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="316" mass="36644" checksum="F675C22B14CBE0BB" modified="2013-12-11" version="1">MSNPNRPRFFTPASKLFTQSSSASSSAPLKFKSTPFPPNGTRDLYEVFSNRTHITPLGSLPEIKHNNYTNVLILLLEPRPQVRNDKDDYYIMDHTSILDSKTGERRKTILSVYRNRDEFRDAAAPGTIMAVYGVGHNTTYQEDIDNGKMRSSTLKDKVDGKIHGHLNIYNLKSSEKRLATEKWWNTDLEQLSKLEGFKALEDWWDDEKEQREAEMLEKERQRLLEEEKKRKEIEEEERQRKLEEILNAEKEEDQVGGKRRMVEKGVGVKVSPSEENAGEKQKKGEGGVTDERIMELDARGKIWYRKGKPFLKFTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC50</accession>
    <name>U4LC50_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_02998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC50"/>
    <dbReference type="eggNOG" id="ENOG502S2VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYLSIRL"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="422" mass="47919" checksum="CAD17D826F27C84F" modified="2013-12-11" version="1">MTTPSFPAPHNLPCSLCLHASSQILCVSCAQASVWEARTQILFATAARDETGDRVQEQLESSAQEFWTKKAEGEGLRERLKGLREEAERLREGRGEDRARIEHLRNEVALRRKKLEDARKIDTERRVMLEGIKAEVKRKNQISKMVYTRMMEARSRLCREVARLYGLRLKRRRSGRVEYLIGGIPIPNLLTDLNIHQYTNFNVSLSHLSHLLVLVSHYLGLKLPHEIILSNRENPHNSIRGPLNNRLTTRPLHVESPLSTLSREDSQKYSRFLEGISMLSLNVAWLCYSQGLQINEVEDATNLGLCMWKLLVANDSTAVDNPAFGKVSHATISGYLANARNGVVMKDFKLRPNLIADRIRYTLQQETMAADWDMMPEAGREMRRRSVQALEDDQEDQGSPAGPSSVTGGVGRWTRIRARNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCI9</accession>
    <name>U4LCI9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein sly1 acc. no. O74534</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCI9"/>
    <dbReference type="STRING" id="1076935.U4LCI9"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="685" mass="75142" checksum="D174F739B49E6407" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD28</accession>
    <name>U4LD28_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_07947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935409">
        <property type="protein sequence ID" value="CCX30019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD28"/>
    <dbReference type="STRING" id="1076935.U4LD28"/>
    <dbReference type="eggNOG" id="ENOG502R4JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RAPAFTY"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="204"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX30019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="514" mass="56362" checksum="AA3BC9168A815C85" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LD61</accession>
    <name>U4LD61_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Uncharacterized mitochondrial carrier C12B10.09 acc. no. Q10442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LD61"/>
    <dbReference type="STRING" id="1076935.U4LD61"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IGPRTMW"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="91"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="187"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX29783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="283" mass="30066" checksum="F839A4461C9AFDDE" modified="2013-12-11" version="1">MDAPSSSPLASPYVRSLIAGGFAGTAVDLSLFPLDTLKTRLQSKGGFFANGGWSGVYKGVGSVIAGSAPGAALFFVTYEHVKSTVSPNGQPGAFAHMLAASLGEIAACSIRVPTEVVKQRAQASQFSSSWKALSHIFTANQGAVAVWRELYRGWGVTVMREIPFTVIQFPLWEGMKEWRGKQKGRKANPVESAVFGSISGGFAAACTTPLDVLKTRLMLAKQRQSALSTFKSIVAEEGTGALFKGITPRVIWISIGGAIFLGAWDFAKGSLEALDRRSRGSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF87</accession>
    <name>U4LF87_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF87"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="105" mass="12223" checksum="5BF2EE94339C61C7" modified="2013-12-11" version="1">MRVGESPNLPKITGRFKRKASENEMARYLACRHTIRLSRVYSLVRDTPRGEQVIRWLTPPALDFRRNGLLSCDLSHNLSKIYIQIQPEKSCFKCQSRESTSATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFI9</accession>
    <name>U4LFI9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to N-acetyltransferase 9-like protein acc. no. Q9USR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935944">
        <property type="protein sequence ID" value="CCX14227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFI9"/>
    <dbReference type="STRING" id="1076935.U4LFI9"/>
    <dbReference type="eggNOG" id="KOG4135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHVPRYH"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX14227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="284" mass="32174" checksum="6C6E5396C2CAF051" modified="2013-12-11" version="1">MHTRASRLAPQESSIAQDHCTDSYSYGSTASKMLLNANTALLSPKILLVPYEPHHVATYNSWMQDEAILEATASERLTLDQEYQMQRNWRKDGDKLTFILCLPPANVASIPTGANLETLSPPIASEPIVANKHDVPEVMIGDINLFLSESHDELPLNDRGMLGKRRLVGELELMIARKEFQGQGYGKAAVLLFLLYVVVRREEIVQKFGEDSVLEYLAVKINQVNERSIALFTSLGFKKTKEEPNYFGEFELVLKDLDVVRVFGLLRLYGLERSRECEYVYKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFX2</accession>
    <name>U4LFX2_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935526">
        <property type="protein sequence ID" value="CCX31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFX2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="30" mass="3068" checksum="141286D402F55C78" modified="2013-12-11" version="1">MCNLDLLHSTSTGGSSAIHGTSNMRSTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG96</accession>
    <name>U4LG96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG96"/>
    <dbReference type="OrthoDB" id="10362829at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="21825" checksum="AA3FD3B9797DC96B" modified="2013-12-11" version="1">MNKSNQPDVVKNLLSEEEYCEILDKEPVGEVSRPTFGECGCKAHDGTDFGKWCTKCLWRRHRLKLSTQLGPSQQLPTPIFVQIPDVPKATFIEAPKMQYGNILIAPSTVPTPEVRTSFGSALPWWGENSAKSEDSGFKFDVQAPVQEDAGPAIQVPGGSRPVHGHRRTQSGLPDAGIPLDEFDFKLTVAEPTGITFTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGD8</accession>
    <name>U4LGD8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935557">
        <property type="protein sequence ID" value="CCX31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGD8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="565" mass="61789" checksum="1CCE0A9B1DEAAE28" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHM5</accession>
    <name>U4LHM5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Coiled-coil domain-containing protein 124 homolog acc. no. O94389</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_10770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHM5"/>
    <dbReference type="STRING" id="1076935.U4LHM5"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX31423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="210" mass="22669" checksum="E4A5A7CEFA918D4C" modified="2013-12-11" version="1">MAGKKLPENSKKVAGNAQKAAAAQAKADAENAKKAQAEAQEWSKGAKSNAKADAAEAKKKEAAAKAAEKAKLLAEEEAAMPSKPKGGKTAVKRGGLDAALNALNASGIDDALDALELTSDGKAVVIDRHPERRFKAAYAAYKDRRLPEIKEEHKGLRLQQMVEIIKKEFDKHPDNPFNQTGIVAHNATREEVQSKRAEERQKIENRLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHU9</accession>
    <name>U4LHU9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Nuclear fusion protein KAR5 acc. no. A5DJU3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_11222</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHU9"/>
    <dbReference type="eggNOG" id="ENOG502QVCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHEQSIE"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651597" evidence="12">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="538" mass="59817" checksum="B692CBE461A3D1A8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHY0</accession>
    <name>U4LHY0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Calcium/calmodulin-dependent protein kinase kinase 1 acc. no. P97756</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_11397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935648">
        <property type="protein sequence ID" value="CCX11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHY0"/>
    <dbReference type="STRING" id="1076935.U4LHY0"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSIRMDP"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="80"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="525" mass="58914" checksum="AFE010D80154F261" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIQ8</accession>
    <name>U4LIQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="13" mass="1430" checksum="7B7397C05B43B40B" modified="2013-12-11" version="1">MLNLLERDGGPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJB1</accession>
    <name>U4LJB1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Phosphoinositide 3-phosphatase acc. no. O13819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJB1"/>
    <dbReference type="STRING" id="1076935.U4LJB1"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTMEGFM"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="337"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="401"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX17430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="765" mass="84921" checksum="AA674F5C993D3EAA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJU8</accession>
    <name>U4LJU8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJU8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="215" mass="24875" checksum="A7A904404A734ED7" modified="2013-12-11" version="1">MDYETPLVVSSDINGYEHTIARRSSCTWNRLRNRRSLPARATLLRCLFTKRPLFLPGLRRLSRTVRGKEKERPPLINYRKVFRSVVLGESSKTVLKDIHRWVLWLFVLLGVGPSCCVLAEFCEKQDQNWARQSQELESSRCLQMYVATETPEAVWEYLRGYTLCPPQDGNLAGWTGRGMGQYQSTPCTNLRHLQQSLNMRNAAIQFHEGTRKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJV4</accession>
    <name>U4LJV4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PCON_11466</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 100304</strain>
            <tissue evidence="17">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935650">
        <property type="protein sequence ID" value="CCX31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJV4"/>
    <dbReference type="STRING" id="1076935.U4LJV4"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANWPMAP"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="16">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCX31822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="530" mass="59092" checksum="CCB9E827359979FD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK55</accession>
    <name>U4LK55_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LK55"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7055" checksum="03B355B81BCBE384" modified="2013-12-11" version="1">MGQMLSTIYTAVTGLINFSCSIADIITAPISYVIDLIDKIIYAIVASLIALGLIAIACLAIFYLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK91</accession>
    <name>U4LK91_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF935354">
        <property type="protein sequence ID" value="CCX29775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK91"/>
    <dbReference type="STRING" id="1076935.U4LK91"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIAPSIN"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="356"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX29775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="690" mass="75658" checksum="ECED6F26E004F3C4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKA5</accession>
    <name>U4LKA5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935779">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2013972at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="27607" checksum="11BC61DC6B7DDE5F" modified="2013-12-11" version="1">MIEVDPSIYVYENGRRYHAYYGTEKYLMPTDEVEQDRLDLYHEIFRVELDGRLHEAPLNERHRELCVISQMIDRTGTGVWAMDIADQYQMAEVIGTDLSPIQPSWLPNDVMKNWTFTDDFFDFIHGRNISAEKVEFEDVQMHVSKERFGPWPKDPRLKSIGAMNLLNGETGFESYGMAAFTRILGMSADEARGICQRGLAACQNKNYHVQRVNASPWQEAIEQIIFVVIILAGEVFGLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKA6</accession>
    <name>U4LKA6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935830">
        <property type="protein sequence ID" value="CCX32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKA6"/>
    <dbReference type="Proteomes" id="UP000018144">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="6043" checksum="A5DE5E57683FB342" modified="2013-12-11" version="1">MRRRDMVEDQDRRGHRRQLMRSSRRGERVRRDQEVMEGFRKLWIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKF5</accession>
    <name>U4LKF5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKF5"/>
    <dbReference type="OrthoDB" id="5292628at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="351" mass="39882" checksum="68DB331DD7DB23F7" modified="2013-12-11" version="1">MSLRPGAYIIRNCETSTVLQITTWNGHGKVELREKDEITNREHQIWWIEEDPGYEELNESEKATKKGGIYRITSIAKSISLDHAQVDKIVTYSSHGASWQLWRIKLCQSATDEGRYEIRPFRKGSDDVLLHVNDKKQPVVGKPQIPMPGPMAGKWEFVYPLNPIPSGWIFLKNASSQRLLKLTYPSLPPIMKNSDDTLHETGEQPLSYLQRWASQWAIIETKSAAILSTSGCSPRTFVIQNRLTKTYLHHRSMLFAHKGQTQTATVDACCSGSEDVKLQEWRFEIDFQSNWKIINNQNGCLLEDSYAPLMDGYEVTCATKSPSSRKAWIFMQFHSPATPFDATASIPCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLT5</accession>
    <name>U4LLT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Probable metabolite transport protein C1271.09 acc. no. O94342</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLT5"/>
    <dbReference type="STRING" id="1076935.U4LLT5"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX32557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="504" mass="54911" checksum="B770D98F7958CCF6" modified="2013-12-11" version="1">MALNPFPLEPASTINSQIMADDPDTDEVPSTKSKWERVWPVFACGAGLYSDGYLNAVIGQVSVMLARIYPKEYENSSARSNVSSIAFAGTVIGQLLFGYIADRYTRKLAMTVSAGILILMAALCTASYGAKGSVEGLITMLVVCRFFLGIGIGGEYPAGSVAAAEATSEVKSGTRNRWFILFTNFAIDVGFVVAAFVPLVFVWILGQSRHALMINWRVSLGLGIIPPFALFFLRMRLEEPEQTKKNTMANTKTPYWLCFKYYWFRLFLVCAIWFIYDFAVYSAGIYSATIISHVAGGDDLVVGFGWNVVLNLFYIPGSFVGCFISDKIGPRYCLILGLILQAITGLLMAGFYGQLATSKYIGAFVVVYGMFLTFGELGPGNNIGLLASKTSATPIRGQYYGIAAAIGKVGAFVGTYVFPIIIKNSGGSDSIRGNQAPFWVSSCLCVFSAGLAFLLPHIGQDTIIKEDKLFREYLTANGYDVSQMGYKNVENRAETGQVAEPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM93</accession>
    <name>U4LM93_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM93"/>
    <dbReference type="STRING" id="1076935.U4LM93"/>
    <dbReference type="eggNOG" id="ENOG502SAKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLCCGIQ"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="410" mass="45509" checksum="0DD290D8439F098A" modified="2013-12-11" version="1">MGVMHLYPRTVEQDVHNFGQTFTSFDRCMQKSVCKIPFIIGCVIAGIIVFTLLWCLIRCIMCGYACCSCCCGGCGGRRHTKEVHNTTYVLPPQPIVDRPPPPVAAMRHDTMPVQRDEPKQYAYFENHNDDALPHMPSADGIDVKQEAKPEVHEMTNMAGRMQSPAPEMGMHNPQPKRPARIPNIEESVSYLYSANGGYGNNYNAAPLISRQHTPPNGPYSLPQQAAAPVGYGHDGRVASPYGQDHDQYPSPPQQATAPGYAHDGRGSPYGQDPYAPPQQAGAPGYAHDGRNSPYGQDPYAAPQQGYQQQGPPHDFRAQSPGYPQSAYPAPTQQPDYHAQQPDYYGQQDYNAPYPQEPAYHQQGPQNATYPAQEPAYQQGHSVQQPDYQQSQYQPYVPPTQQRKPDPWTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNC3</accession>
    <name>U4LNC3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNC3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="44" mass="5120" checksum="4344499B2F022C5D" modified="2013-12-11" version="1">MGYAILNATPEWTAASRVTHEHASDQVRRWLFTASSIRRYSILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPA5</accession>
    <name>U4LPA5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Putative sterigmatocystin biosynthesis monooxygenase stcW acc. no. Q00730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936056">
        <property type="protein sequence ID" value="CCX33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPA5"/>
    <dbReference type="STRING" id="1076935.U4LPA5"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFQVGCR"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF11">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="572" mass="65305" checksum="E0E74B8644E6633F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPD7</accession>
    <name>U4LPD7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to BTB/POZ domain-containing protein 1 acc. no. O74881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_01152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936082">
        <property type="protein sequence ID" value="CCX33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LPD7"/>
    <dbReference type="eggNOG" id="KOG0783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQRDDFG"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="886"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1200"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1262"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1438"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1556"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1698"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1473"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1492"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1569"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1580"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1755"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1792"/>
            <end position="1806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1814" mass="194182" checksum="F22D0E517B488CA8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPE2</accession>
    <name>U4LPE2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936091">
        <property type="protein sequence ID" value="CCX33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPE2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="102" mass="12405" checksum="0FFB120CA4061026" modified="2013-12-11" version="1">MIFDTIRWNLVKSWRGLARTSPSETLAKSIIFRRILDPSFQKRHWLIAERRRPMMPGLEETIPLWFQKQTNALLRRDRWYLHRSLLGWHMYSTNHSKSVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPK2</accession>
    <name>U4LPK2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Metal tolerance protein 5 acc. no. Q5NA18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_02574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="386"/>
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    </feature>
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        <location>
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            <end position="419"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="32"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="513" mass="57435" checksum="47FAA9F105EBE417" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <name type="synonym">Pyronema confluens</name>
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            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
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        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7496" checksum="5FCDD1E4194C9022" modified="2013-12-11" version="1">MTQAIKVPFVPSSQTLDINQYRISMASCFSYIHKRNSKSYITSIPTYIFAFIHFRSPPTTRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPX4</accession>
    <name>U4LPX4_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="DUF155"/>
    </dbReference>
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        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="260"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="327"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="593" mass="66779" checksum="1FB1C6734E3ACAE8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQE6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Vacuolar morphogenesis protein 7 homolog acc. no. O74509</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQE6"/>
    <dbReference type="STRING" id="1076935.U4LQE6"/>
    <dbReference type="eggNOG" id="ENOG502RXJQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DSFDTRW"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="344" mass="38302" checksum="715EA652DF67ABDE" modified="2013-12-11" version="1">MSLTLTIPTTSETPPPRSYTLYHILLRTSVRSYSLPKRYSDFLTLHSALTTACHAAPPLSPPPKHYLFSTLGSPSRTEERRAGLEAYLYAIINHTDSRWRDSAVWRSFLSLPASWINNSKTPQQQLYSPVSGGPITDPALWVDSHRELKTLLHQSRTSIQTAQEKGEGWQDAKRLLMKAGGLIAALEQGLNEQGEKEKPLLDGEMRRRRDLVAAAKQDRDALETLATMLSSSKNSAAKNTAAGGDKPPASRFQGTRVLGAPIPETQATRELDNKGVLQLQEQVLKEQDKGIGELLRIVERQRAMGTAITQELELQVEMLKEMEKDVDRVDKKTRGARRKAEGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQW7</accession>
    <name>U4LQW7_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Putative ankyrin repeat protein L93 acc. no. Q5UPG5</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_03503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936512">
        <property type="protein sequence ID" value="CCX34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIACERR"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="234" mass="26369" checksum="4FB6FD11379848E3" modified="2013-12-11" version="1">MIACERGYLEIVKLLLDRGDIDIKAVDRYHGRNTLMIACERRYLEIVKLLLDRGDIDIKAVDENNCNALMIACKLGQLEIVKLFLDRGDIDIKAVDRYNCNALLLACERGYLEIVKLLLDRGDIDINTKSSSGDTVLIVACCHFKSDKSVHTLELLLGRRDLEVNATNQHGDTALIKLCKQFYEQETLAGTLLKRQDIDVNIKNKEGKTALMIAKENGHKNIAKLLETRAGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRU0</accession>
    <name>U4LRU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935409">
        <property type="protein sequence ID" value="CCX30011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRU0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2255" checksum="8F4E70C18C3E744F" modified="2013-12-11" version="1">MMHITFCIPPASHATPYFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS17</accession>
    <name>U4LS17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 3 acc. no. Q9FIY7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_12395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS17"/>
    <dbReference type="STRING" id="1076935.U4LS17"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NLVDHWL"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="941"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="873"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX32125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138425" checksum="084B27F262D5D9AA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS30</accession>
    <name>U4LS30_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to RCC1 domain-containing protein 1 acc. no. Q8BTU7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS30"/>
    <dbReference type="STRING" id="1076935.U4LS30"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHMLPGR"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052830">
        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849:SF1">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX32140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="279" mass="30014" checksum="3CA3EB0FF1298BA5" modified="2013-12-11" version="1" fragment="single">MPHHELLGCGFNAHSQLSFAKYGGAQSTRASSPEDIRSPTSLITTTSTGDDKTLKPVFIGWSDVLLQQDEEVFWYGAGRASKANEAKPAPLNLHGAAASSLSFIGDHSGPLAALSKTGEILLRSGNEFLPAPELGTDWQHIAIAGNGIVCAVKQNCRVFSFPSFSAFTNSCHTRIWSIPTLRILQLIANESSFTLLSHEGEVYTWGDSRYGLGREVTAEEPASEPTIVTALEGLKMVKISTGAWMAGAISNERDLYIWGRASIDQEIEGMGEGEGEVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LT20</accession>
    <name>U4LT20_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LT20"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="139" mass="15706" checksum="4715DB77B4552B57" modified="2013-12-11" version="1">MLGRNLCLAVVGIQGAPGQSKISRNRDRTQFTPQTFAATLLKHQYLGAFATRRLKPKYCKALEITPPEREYCSRYSVGKERSKNNGPLFLVVQDCHRWMEKSLLGSEHDENVKLKEDVQAMNSKVQPGVLQGLVMVDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU76</accession>
    <name>U4LU76_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU76"/>
    <dbReference type="STRING" id="1076935.U4LU76"/>
    <dbReference type="eggNOG" id="ENOG502S90D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GTMHQWV"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="183" mass="19504" checksum="AF779906E661397A" modified="2013-12-11" version="1">MAETNLRPLQRLITTHNEAGQAIFSSALPETAPTTQVAPGLNFTLGYSTTSFPASLANDSDITSYSTMLSQPPGLAIPNGTVCRIVEFAPGSEPIMHRTVSLDYGIVLEGEIELELDSGEKRRMERGDIAVQRATMHAWRNVGEGWARMCFVLTACEAPVVGGKPLGEEGTGAVQKEAEGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUQ8</accession>
    <name>U4LUQ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935655">
        <property type="protein sequence ID" value="CCX31861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUQ8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="202" mass="22094" checksum="F0C1C7ACDCDA47FF" modified="2013-12-11" version="1">MFLSFVETSSLFQAANGAASSPPRNQIVSSSSCKARSYQRQAKCRSSTRIAKRKVVCQADKKPAVASTPRQIKRFAQAGRSWELLEKATTVAKDHKVIEGFARMTLVPESQPVRAATQTVYRTAAQPAVTAGCTACNLGLQTTVPISSHTYNPIWHPASRTADRSTRVAEDLKENQTVEQHRDGTLAFSVEEGEKPVEMVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVC8</accession>
    <name>U4LVC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PIF-like protein [Medicago truncatula] acc. no. XP_003611824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVC8"/>
    <dbReference type="OMA" id="ELCVICG"/>
    <dbReference type="OrthoDB" id="5430673at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="372" mass="41358" checksum="48FC403C408F7658" modified="2013-12-11" version="1">MPSLRQCPVKKLLRDRPPPLHQHQSSPIDLPTKTMSKASEKAPQAEWTTAMTRTLLNVLLDEAAQGRAPGNDFKPTSYEWAVLAVNVNRLGTTNNITPITIKQAIDKVASLKRDYGRFKFLTGQSGVKWIKGSGTVDMEASVWDRLIAENVKFARFRKKGLEFFNELDRLFQGKGATGPGDQAASQLTANLIQKNAAVPSSITRSVAGIQIPNTPRPAKPAPAPTIAPADTVRSLNAVPLPPQKAAPPPTTATAEAGKADKLLPGREAKGIQKRKSASVNGVSQNAIEDSVTIVRKEFMGTFNQQQLSIIWCFFEDRYKARMFMSLPKGHRKDWLLKQIKSYQWEQEDRALEREVKRLKLQKLLRECKEQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVS8</accession>
    <name>U4LVS8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936636">
        <property type="protein sequence ID" value="CCX34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVS8"/>
    <dbReference type="OrthoDB" id="10513966at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="419" mass="45418" checksum="7AC80B16D8FBAB27" modified="2013-12-11" version="1">MSDNPYLLSGLQEARDMTVTEAAEVFEAVETTGPVKKAPKRRKAAARYSTPKARKAAAARKARAKMIPEGPVQAVDQLIEEPEDPNGTAEHMDDHELNENPGPGGDIETIGLTEPLQTVGSVEPEQLKGHKSRKDPQPKTPNADATPKVASTRNLKEPVGVIEPVQPTGLNGLHDSVSLTGPGALNKINGTQTIHGIDKLNGTGELCGPSEIYGAERFYTPDEQNAPSDSANLIESTGHIAPDEQLAYPAAPSVSTIRKSSRKPAPRKVMTANNLPKTVAPAPRKISKKPSAPKAAHAEELARVYQEVYSDGHAANGIDDDIQGIEAEPYPSEVREEIKKLLRLEEDKAKVDKEIEDRFSHNPEDYQAFEAKCYQAQAALPNKFCKEFNGSIAPGSHEDSALTFLWGIQSNAVPMKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW35</accession>
    <name>U4LW35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_14142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW35"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651987" evidence="1">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="154" mass="17441" checksum="85AD345B77518F5F" modified="2013-12-11" version="1">MVSALTLSVLLLGAITPLVTARLPFHSDQTLGKALGFSDPIRRSSTMLWPRLLYCKSRGFRILQRGRQCDDRPREPFTCYNLKEYDRKITSHEVLSGCCKFFFEENCKSKMFGACAGDSDGLSIQLKPAWYKKARSFLCCEKDGGDPNCHRFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW64</accession>
    <name>U4LW64_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW64"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="26" mass="2875" checksum="44FBBF7C1AD8611A" modified="2013-12-11" version="1">MQYGLVVKKCFAYVNSGAHSPHPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWF2</accession>
    <name>U4LWF2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936162">
        <property type="protein sequence ID" value="CCX33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LWF2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="99" mass="11336" checksum="D6EBD412E83D3C06" modified="2013-12-11" version="1">MKHVIMSHGRKLRSTLEMLPSTGVEEEHQQILASYDGLADADASEGSYNACSWCSEDCGCLVDHRGWCTQNAEYILFCHYCTAEYIEYIRYHSLVDHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXD4</accession>
    <name>U4LXD4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936526">
        <property type="protein sequence ID" value="CCX34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXD4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="89" mass="10400" checksum="A8A263742237ED0D" modified="2013-12-11" version="1">MCKQNPGQARHHRPNNATVQLGFRWLILDAQTPDTGTVTYRTRCYIIKSDYTPNNADNKENDNPDRVDQRFRAVIVRRRPPLPAIPQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LY51</accession>
    <name>U4LY51_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936618">
        <property type="protein sequence ID" value="CCX34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LY51"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="6408" checksum="7FD34CB5EA92B67F" modified="2013-12-11" version="1">MLLPVCIDCYTPSQLSVPRLDTEFYTRTLFWQNYKLQGYERDLASMSNIKSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTY3</accession>
    <name>U4KTY3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_01772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="HF935197">
        <property type="protein sequence ID" value="CCX04282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTY3"/>
    <dbReference type="STRING" id="1076935.U4KTY3"/>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQMRNTH"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX04282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="331" mass="35226" checksum="968B62C762625896" modified="2013-12-11" version="1">MPRRLSRSFITTPSFTGASVRIVEVGARDGLQNEKTVIPLATKLELLNKLSKTGLTHIEAGSFVSPKWVPQMANTGSILEVLEQERRAQGQDGDGITYSYLVPNIKGLETMLGVKGTAAKGNEIAIFASASEEFSIKNLNCGIEESLRRFRPVVESALEHGLQIRGYVSMVISCPYSGPTSPQAVGDVVERLLEMGCYEVSLGDTNGVGTPGTVGKLLRHLVQERGIKPERLAAHFHDTYGQAIVNSLVALEHGIRTFDSSVGGLGGCPYSKGATGNVATEDLVYFLEGTGVKTGVDLEAVARIGEWISKVLGRGNGSRVGRALAGSKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4KU89</accession>
    <name>U4KU89_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KU89"/>
    <dbReference type="STRING" id="1076935.U4KU89"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIGERDY"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1002"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113424" checksum="F8A7CF941FEA4E29" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUP5</accession>
    <name>U4KUP5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1531-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935206">
        <property type="protein sequence ID" value="CCX04476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUP5"/>
    <dbReference type="STRING" id="1076935.U4KUP5"/>
    <dbReference type="eggNOG" id="ENOG502SFRQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14530" checksum="0CB16074B1F8D147" modified="2013-12-11" version="1">MVNHFEFGFDPEARTLTILGRAYDFNVLMRTLIITCAYILLRPYLLKLTSRHQERDHDREPTEADEMSSPAATGRVAPGGEEDSDGEDNSWGAKARRRQRAMKQKAMDEDREADEEEDAELNALLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV00</accession>
    <name>U4KV00_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YLR063W acc. no. Q12291</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935243">
        <property type="protein sequence ID" value="CCX05283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV00"/>
    <dbReference type="STRING" id="1076935.U4KV00"/>
    <dbReference type="eggNOG" id="ENOG502QR34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DMRYQVH"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="349" mass="38898" checksum="B86E6CDFD6F43A52" modified="2013-12-11" version="1">MGVRAPKDGNRHGYDENRILDTGSSKPKAPAKPTKKPQQVKSKRLPVAPKPSPELVASKEIINLFQQTFSAALENPMLHTLLQTVKGHLFNRDYTAAFGSDENLQGYIVRWSPSRALCYRSVFLDLTDLLRDVFETEQAKDKEIVCIGGGAGAELAAAASATKFLIPRDPEESKGKVVMTGIDVAAWGPVFDKLLGGIHNGFISEERFTAQFKQANILDVDLKTVIGRKTRLISYLFVTNELYTESRAKTTKMFVELGSCVEKGCLLLVLESAGSYSMVKVGDKEFSMGMLLDHTLLAGGEWEKVVEEESRWYRLPQAPVFNGQVIGTGLRYPLQLENMRYFVRVFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV65</accession>
    <name>U4KV65_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_03652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV65"/>
    <dbReference type="STRING" id="1076935.U4KV65"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX04761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="294" mass="32676" checksum="13B4E8EB14991A0E" modified="2013-12-11" version="1">MILANLARAQRTTSLFKHLHITKRTMKIHSIPMRTGTGDNYAYLLVDDKTQDAMIVDPAFDDEVLPVLKDFVNSKRINFKGIINTHHHFDHAGNSEHGNVAILAEYPGLPVIGGVKCHLKTETPSHESTFKVGELVVKALHTPCHTQDSICYYVEDGNDKAVFTGDTLFIGGCGRFFEGNGEEMHHALNVVLAGLPDDTKVYPGHEYTKDNAKFCAHILPNNAAVKKLQDFCEKNKETQGKFTIGDEKKHNVFMMVEDADVKKAAEEHGPKNVHGNGPAQVMEKLRTMKNGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV79</accession>
    <name>U4KV79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV79"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5344" checksum="20A369CADF8E62E1" modified="2013-12-11" version="1">MFPTHAETRHFVNGSRILMPFAHQNTASRNHSKHGSQSYKCNTEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW61</accession>
    <name>U4KW61_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935245">
        <property type="protein sequence ID" value="CCX05311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW61"/>
    <dbReference type="OrthoDB" id="10341376at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="227" mass="25318" checksum="94DCC23A469ECC3D" modified="2013-12-11" version="1">MTNQSHTNGNTQSPTQNGHYTPEIMSNRSDTNGNTQSPTQNGHYIPDGAYFQLSSLFGKIMQLLFLTADITWAKVGTQYSTDRIFEKHSDEYDDLSLKVDGAISTILQEITRISTANESARHIVEMARSHIDSKVAEKGYPTPAGNYRYAWLVGTTKDVDESLWVETFDSIVTALGPEAAEEMEDQAHARNIYAKRMEYCAILGYGPLDMALGMDLSSIVYWETHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWC8</accession>
    <name>U4KWC8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWC8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="38" mass="4401" checksum="941A2048444BDC77" modified="2013-12-11" version="1">MQTKTRARFAGQAPIVMQSRSYLIQRPPTYVEYKQKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWE4</accession>
    <name>U4KWE4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Demethylmenaquinone methyltransferase acc. no. Q64XV8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWE4"/>
    <dbReference type="STRING" id="1076935.U4KWE4"/>
    <dbReference type="eggNOG" id="ENOG502SJGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMHHIYL"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="37986" checksum="98B41FF22B0D7E10" modified="2013-12-11" version="1">MPTPFDKEGPTLEVDPKQEETDYYESGRHVDERSRRIGNHFAVFFGTPLAKRRRYHAYRAGTYALPNDETEQDRLDMMHHIYLLLLGGQLYSAPLDNPQRVLDIGTGTGIWAIDFADNCASAEVIGTDLSPIQPKWVPPNVQFLVDDAESDWTFSKNSFDYIHLRGLCGGIEDWPHLLNQSYETLKPGGYIESFEFHNFNLFSDDGTYNSSTAMWRYYDLINKAAAKSGRPLTPKEPFRKTIADAGFVNLTEKKFKLPLGTWPAEQKMKELGRWFALVGDSGFEAHGLALLTRVLNMDVKEVRKLMDDCRAEVKGRKVHGYGVLCLVVAQKPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWJ2</accession>
    <name>U4KWJ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935256">
        <property type="protein sequence ID" value="CCX05521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWJ2"/>
    <dbReference type="STRING" id="1076935.U4KWJ2"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="38256" checksum="BF8D0C2DEA0461D2" modified="2013-12-11" version="1">MMSLGAMTKCTPRLLISSATRPVYSPDHNLTSATTIPQSHSDLSSSPINTFDTGGGFKPTTSSTRSSSIDMSDTAGGFMPTTTPMTPPQSSQPAPSPIRPLLTTKKRMERFENRLTQVHRRHITRFTQGGYEYSQEFVQDLLLILNDMPDEMQCLLQIANVFNENLYGYSIKWDEWNKIFELLRKLDEAFYAKLTAPLETGKRGVDMTEKVRLKSLIERTRMHIVQLPEDGHDDGENEDGEDPEVLPQEESDSEDEVEPVKGAMQLAAEGVKQGEAGRVPVECTPGGMLDMPSDVNERREEELEELDDDDDEEDEAELEWEIEVSRVYIKTMEVLGETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWV2</accession>
    <name>U4KWV2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935289">
        <property type="protein sequence ID" value="CCX06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWV2"/>
    <dbReference type="OrthoDB" id="10443213at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="221" mass="24827" checksum="95C0A962010EB605" modified="2013-12-11" version="1">MPNLTDRTDTMPEMNPRTALPDPTDDAMDEADRVQARNQAMVDAMLGRTRARPPPPAPYPGVHIWYERFNTKVVNEAINQTATEAELEELESKTQRKARNEEYKCSKVETTTDVNVENSPVIADDTLSDNRKRTRRGTTHSRDGCELDYLAELAAILDIEDGEIPDIMNAESSIGLKDGLLFDSNNRNDTNEYLEPLLNVMKTEAKVTPMIENFVKISVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYG2</accession>
    <name>U4KYG2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein BOI2 acc. no. P39969</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYG2"/>
    <dbReference type="STRING" id="1076935.U4KYG2"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="244" mass="27005" checksum="4748FC5D3C70CAFE" modified="2013-12-11" version="1">MSSTDAGGDAHHNYHNHHSNHLPVPIELNDSSSEYSIQEPSHDVFSSDPSDDDDEDDDEDVKSDISMSEYSGLDEIPFTRADVMKWSPSDVSSYFKSRQMSPGICAKFEEQEVSGAILLELEMSHLKELELGSFGKRFEVWKEIEHLVKNLKQYSAPSKPRSGSDAASRQTRCPAAYTQSACSTGIAATNDYIPGNKFAAIQRIGIVVTKIFVEYNVAPDITTKKRLVGTAKVSAYVTAKRFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ35</accession>
    <name>U4KZ35_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Golgi apparatus membrane protein tvp15 acc. no. O14223</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ35"/>
    <dbReference type="eggNOG" id="ENOG502S5TF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDYSDAF"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX07296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="128" mass="14071" checksum="98953EB1A92396F5" modified="2013-12-11" version="1">MDTNIFRFANITVGVIMVLGGISQFFPLSLQSVIIGCYVILFGLGTALLEFQQPPQQISRYASFMFSFLGRGLFYIFIGSILLHDGVLRVIAGSIVGFVGLGYAALEFVPSIEPPENMRDAQWDGEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0N1</accession>
    <name>U4L0N1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0N1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14395" checksum="680E9765D7D078AA" modified="2013-12-11" version="1">MHAADQTLAIRGLHIWMWWTGEMAAQHLVVKCNKHMAEVKRQIFRKENKATEKQNQMPLLGIRVLAKLEREAAAAEVLSPLIVDLQSCVNKHPIMEDIKDGYDSYSIWSALCLLAERCVIKERRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0U4</accession>
    <name>U4L0U4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pathogenesis-related protein 1B acc. no. P07053</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0U4"/>
    <dbReference type="STRING" id="1076935.U4L0U4"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="13962" checksum="CF75DF03A17E7A0B" modified="2013-12-11" version="1">MVNILTIAALAHGSPRLTWSNALANEAQAYVNKCTDVHEGWEHHHHGDCLASGTPPFLTGPAHVVERFAEEQNWYDYQTGKSKRPDKPIGHFAEIVWSGNKEVGCGVKYDCHNHKFPVQHVCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0V1</accession>
    <name>U4L0V1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935447">
        <property type="protein sequence ID" value="CCX09252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0V1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651814" evidence="1">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="17589" checksum="A1983724EC2174CC" modified="2013-12-11" version="1">MKFTAIALLSFTLLTSAAPSLEKRNMDICHFKDATVDGQLAINPAKPGVVKCCNTTPGKCIESSQCSASHPRQWCCPPWSRNLNGCSIFFGNPKSAGPRKCLARPFYNGLLACCKQIGGGRVTCVDGKGPVGGNCAGEFSQQYCCIAGPNRKQWNECQASYTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1E1</accession>
    <name>U4L1E1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_07885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF935408">
        <property type="protein sequence ID" value="CCX08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1E1"/>
    <dbReference type="STRING" id="1076935.U4L1E1"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="130"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="585" mass="64272" checksum="80557FAE173C55B3" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1Z6</accession>
    <name>U4L1Z6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_09269</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF935487">
        <property type="protein sequence ID" value="CCX09676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1Z6"/>
    <dbReference type="STRING" id="1076935.U4L1Z6"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase SUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="87"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="274"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX09676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="440" mass="49503" checksum="CCA88C5A9C7E18EE" modified="2013-12-11" version="1">MSGEEDLIDYSDDEAIESKEAPSTANGDKKVDATAAGASATQAADKKGSYVGIHSTGFRDFLLKPELLRAIVDCGFEHPSEVQQVCIPQSILGTDVLCQAKSGLGKTAVFVLTTLQQVDPVPGETSVLVMCHTRELAYQIKNEYARFSKYMPDVKTAVFYGGTPMQKDVEILKNKDQHPHIIVATPGRLNALVRDKHLRLGSVKVFVLDECDKMLDQIDMRRDVQEIFRATPQQKQVMMFSATLSQEIRPICKKFMQSPLEIYVDDETKLTLHGLQQYYVKLDEKEKNRKLNELLDQLEFNQVIIFVKSTQRATELNRLLCECNFPSIAVHSGIPQEERIARYKQFKEFNKRICVATDVFGRGIDIERINLAINYDLPADPDSYLHRVGRAGRFGTKGLSISFVSSKEDAEVLDKIMERFEVSLDPFPEGGIDAASYMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L263</accession>
    <name>U4L263_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935446">
        <property type="protein sequence ID" value="CCX09230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L263"/>
    <dbReference type="STRING" id="1076935.U4L263"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13348" checksum="B53A5818D610544A" modified="2013-12-11" version="1">MESQRTSHGACIFSHHAPGQAEEAGVDIRAGDIMQFWKAEWTFEGGGWKKAGDPDHTAVVVGATRDSNGSWVCQVLEQNVGNAKHVQHGEYVIGTNSGMHDGAARVFRPVWEGMVNIDTEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Z4</accession>
    <name>U4L3Z4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Uncharacterized protein C18H10.07 acc. no. O60138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935574">
        <property type="protein sequence ID" value="CCX10901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Z4"/>
    <dbReference type="STRING" id="1076935.U4L3Z4"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KSAPRYW"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX10901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="317" mass="35839" checksum="971792A3D7147B17" modified="2013-12-11" version="1">MSEYWKSIPKYWCKHCKDYVTDTPLGRKNHDETSKHQGALKRFLRDLHRNNEREIQASENAKREVARLNALVGGSGDGSSTTPAPIPALSVAKPELSKGTRWGVAKRELTAEEKKKQMKELEALGVAMPEEFRGDLALPGEWTTVAIEEGPKPLTEKEILQKELAEVRKKEVEEAERKRKWDELDEDEKELRGFRIQQKTYPGANGGDQEEVDFKGLFKMRGRGKKEEESKGGAMKPVAFKVKKEEKAEEEAKDEEEKGPAVKREREETPPGIDVKVEVDEEAAAAVKKEEEEAPAVGSGLVFKKRKVKTMRKKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L449</accession>
    <name>U4L449_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935579">
        <property type="protein sequence ID" value="CCX10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L449"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7520" checksum="8628C279C5A4D09A" modified="2013-12-11" version="1">MKRKGELKGSVNIAIASRIHQHRHHQPSSKHHQLQARVDTGSARHNEAAQSFIKKLVESPASFVSGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4F0</accession>
    <name>U4L4F0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="HF935219">
        <property type="protein sequence ID" value="CCX04900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4F0"/>
    <dbReference type="STRING" id="1076935.U4L4F0"/>
    <dbReference type="eggNOG" id="ENOG502SHA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMTPPNM"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="528" mass="59047" checksum="15A7653B8F0ADC4D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4H8</accession>
    <name>U4L4H8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4H8"/>
    <dbReference type="OrthoDB" id="5368703at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="204" mass="21738" checksum="11901A0258D53570" modified="2013-12-11" version="1">MDSPPSPSSTDTDTSSNGTSTASSSTASSSYSSDSQFLSHAGLIAQSGDCCPPPPPSPADDSEGEHPDPELDRQLAIAIAHIYTPTPIRSSTSSSQSSTNQSVQSDYCNSSGQSQSKRTICNHSLIARIYTEEARCYHCKKAHFFGWVYRCRGCGYRVCHNCRPRFVERSWDSIGGLIRVDVPEGVAGVDGGPWPGWGTVGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4I4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PCON_10978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX11384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="53" mass="5913" checksum="A6C69ED19F72ABB1" modified="2013-12-11" version="1">MNNEQGCTPKPRIQKLRLSDPHAVNGSRVSCALAYSNLYDVKTKHLASNNSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4M9</accession>
    <name>U4L4M9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma acc. no. O60331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S39H">
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    </dbReference>
    <dbReference type="OMA" id="GDMGYSG"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF126">
        <property type="entry name" value="PIPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="45"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="425" mass="49661" checksum="F13F8D8C763309EB" modified="2013-12-11" version="1">MPNHENNDHHHHPHEVEGPQIYDWSHALQQSSKHTLIGRMVIPFFSARYKTALTAACLLRALNERVLPREEEAIETTQLLKKYGKGSLTKPPAADHTFRLNSFFSLYHANFHRAAPLLFYTLRKDCYGLDEEHYQKQFEKDLKPVDGLGFSGSLFYYTQDKSLIVKSVGRKFEYTFMYEKMIEGFTYYYSMMISQKQQTLLCQITDVVGCHDHRLGGWLGVSPSHYIVMTNVLEGLDKEKGCKKWDLKPQNFFEPTRDLVPDQVKTENAKSGLADELDEEMVLTRKDKQTLMMQLERDTEFLADMKTIDYSLLLGRWPVDMFHAPRSGEGRDPMVLPEEDTKDFVRGVRSADGKWVYKMVLLDFFWNVEQLKPKIMQTAGKLLPEQTVTTEPDRYREEFLKMMDKYILVWEDMDEDERLQNSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4W2</accession>
    <name>U4L4W2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935574">
        <property type="protein sequence ID" value="CCX10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4W2"/>
    <dbReference type="STRING" id="1076935.U4L4W2"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5375558at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65145" checksum="BDCEEB0765FA720E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4L515</accession>
    <name>U4L515_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YMR244W acc. no. Q04018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935578">
        <property type="protein sequence ID" value="CCX10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L515"/>
    <dbReference type="STRING" id="1076935.U4L515"/>
    <dbReference type="eggNOG" id="ENOG502QWHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="285" mass="31177" checksum="E774707A4C153D41" modified="2013-12-11" version="1">MVGIEKRQVECALPSHPDIQAVTSHLGNHGWAMSWDKPCLPGMHCQYACVPGKLMHQWDPTPTAYRHPESERGGLYCGADGIARKPFPDRDYCYQARHTLLVVSHLGQKTFVCQTVLPGDEAMRIANPVVAGGMQRLAVPGAKYWIAQGSHCYVNSGGYDVNTACVWGSRDIPTGNWAPYTIGLEEREDGIIFVTVGWNPVWLETATPFRSQVPDFGIKVACHGPHCENTPCTIDPAIHSVNQISHPQNHFNGAGGGAACVTNYSPFTDDANVVLFPARQGHLYN</sequence>
</entry>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
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            <end position="26"/>
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX07398.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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        </location>
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            <end position="83"/>
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            <end position="78"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17453" checksum="6EEA55F1F4A440B1" modified="2013-12-11" version="1">MSSKQTTTITGNKFFCQSSGCEFAEKPFTGDDAEIQYKRHLNKHKLLCPIKDCPRSRNGNGFSRADNFKTHMKGHEGSRSSTPVLTGRIQRLKSPGKDVHKEAVGALQKILLETVAQLGEFKKQFGDSIDIVNKQFGDSIDVVNTPLSPPKEEDALSS</sequence>
</entry>
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                <person name="Gabaldon T."/>
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                <person name="Kumar A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="113"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="363"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="682" mass="74586" checksum="332544C9EE74E41D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935619">
        <property type="protein sequence ID" value="CCX11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5K4"/>
    <dbReference type="OrthoDB" id="10515884at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="710" mass="80224" checksum="53935386A5FE9070" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5L7</accession>
    <name>U4L5L7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Elongation factor 1-gamma 2 acc. no. P36008</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_11700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5L7"/>
    <dbReference type="STRING" id="1076935.U4L5L7"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="251"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="414" mass="46618" checksum="FD2CDEB92A5DDBA0" modified="2013-12-11" version="1">MSFGKLYSYPDNPRTTSLKVVAKANGLDIEEVLEDITKGVSAEYLKINALGKVPTFVGADGFVLHECIAIAVYFTAQNEKTTLLGKTKQDYASILKWMSFANTEVLSNLGAWFRPLVGRDPYNKKNVDAAQEKALKAIGVLEAYLQDNTFLVGERLSLADIFTASIIARGYMFVLDAQFRAAHPAVNRWYNLIRNQDIYLAVAGEPTFIEEAVKYTPPKKEPKPAAAPKAAAPKPAAQQEEEEETPKVKEADHPLKANAEGVKQLDFDEWKRTYSNNDTRSVALPWFFENIKEKNVSVWKVEYKYNDELTLTFMSSNLIGGFFARLEASRKWIFGSMSVYGKSNDSIISGAFVIKGDNFEDAFNVAPDWESYSFEKLDVNNEEHKTFIEDAWTWDKPLVVGDKTYEHADGKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5T0</accession>
    <name>U4L5T0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Uncharacterized transporter C1683.12 acc. no. Q9P6J0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_11156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935627">
        <property type="protein sequence ID" value="CCX11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5T0"/>
    <dbReference type="STRING" id="1076935.U4L5T0"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERRIHIA"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="491" mass="53985" checksum="D4B520EA5BB44E67" modified="2013-12-11" version="1">MSATREKMEKADVTTTMEDGSIKEKAQHLEIVLPESLRNISPEEHARLEQALIRKIDLRIMPMLVLMYVLNYLDRNNIAAARLSGLEADLKLTGTQYQLSVSILFVGYITMQVPSNMFLDKIGKPSLYLPSAMIIWGLISGATGGVKGFGGLLACRFVLGIVEAAYFPGSLFLVSSWYTRKEIAFRTAILYSGSLISGAFSGLITAGITNGMDGLKGLLAWRWLFIVEGAITVAVAITAYWILPDFPKSTPWLTEQERDLAVWRMEQDVGERDWEGGENEDTFYGLKLALTDGKVYALMAILFGELSSASFTNFFPTVVATLGYNRIISLLLTTPPFVIAVFTTFLNSYHADRTGERYYHITIPLWVSIVAFILAATTITTAPRYLAMMLMVPAVYSGYVVSLAWITNTLPRPPAKRAAAIAAINAVSHASLIWTPFAYPSSAGPSYVGAMAMNSGTAALSIVAATGLRWHLAKENKKMDRQGVEGFRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L654</accession>
    <name>U4L654_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935382">
        <property type="protein sequence ID" value="CCX07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L654"/>
    <dbReference type="STRING" id="1076935.U4L654"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THIFFKT"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21504" checksum="8566F1F6BA62606C" modified="2013-12-11" version="1">MFRPAALTARSVALRASYATKATTSVVPRAHSKIAAPSAEDTHVPAPVDTATSCYSPISKHPVNRSENDILDAAVVSGAPIELQARTVRIYKPAKPATQSGNWNGRQWKMDWDVLPRGHRWENPLMGWQSSGDFMQGTHIFFKTKEDAIHFAEKQGYEWFVQEPNTRQFKSKSYASNFEHSPKKLKMIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7T8</accession>
    <name>U4L7T8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Putative HC-toxin efflux carrier TOXA acc. no. Q00357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_08836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935446">
        <property type="protein sequence ID" value="CCX09243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7T8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHDPVQV"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000784">
        <property type="entry name" value="MFS drug efflux pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX09243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="562" mass="60479" checksum="E134053A2F23E177" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L853</accession>
    <name>U4L853_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PCON_09037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 100304</strain>
            <tissue evidence="12">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935465">
        <property type="protein sequence ID" value="CCX09444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L853"/>
    <dbReference type="STRING" id="1076935.U4L853"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPVRYWD"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="524"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCX09444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="741" mass="81726" checksum="0284409A13902213" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8D4</accession>
    <name>U4L8D4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935972">
        <property type="protein sequence ID" value="CCX14386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8D4"/>
    <dbReference type="OrthoDB" id="10602709at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="162" mass="17875" checksum="6BCB781DE02EF89D" modified="2013-12-11" version="1">MPPTTPVSTGNPMFNFFSSMFSPALFSLYIPPFQVPFELKINPRNSLHSVITQLLKDITSKTNYNPNRHYQHPSANDWVLIDITKGSDNKLIHGSLAKDYIQDGATYLVLSARGAVEFGNKAGSQGKRIKQEEVLKWLEAIAPGTTMWGTPEGSDDGTFSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8I7</accession>
    <name>U4L8I7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Cell polarity protein alp11 acc. no. Q10235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935290">
        <property type="protein sequence ID" value="CCX06459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8I7"/>
    <dbReference type="STRING" id="1076935.U4L8I7"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="245" mass="27656" checksum="BD2A35BB586CB4C7" modified="2013-12-11" version="1">MQTAADVTVLVSSDNSFSERRINPSWTISALKAKLYPITGIPVGSQQLTLRLPQAPAPINIVAVDEDATQLSQFLLQHSIGAEIHVTDLRPPSARPNYRDVSEIEKYEMPKDQYEKRTDSVRAWKQRNNLGRFDPEKDAKEAADLERRWKEVNDLGIEVGKRCRIGGVEAQKRGTVRFVGLVKEIPNGGLWVGVELDEPVGKNDGSIQGVRYFQCKPNFGSFQKPERVEIGEFEEIDDFEDLEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L936</accession>
    <name>U4L936_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX10036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L936"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="44" mass="5111" checksum="CA745DCE6039113C" modified="2013-12-11" version="1">MLVRDFRENMRYLVCAIAKDLHDIVDALRVLKFDTLTEKLANGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9I3</accession>
    <name>U4L9I3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Cutinase acc. no. Q8TGB8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_01521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9I3"/>
    <dbReference type="STRING" id="1076935.U4L9I3"/>
    <dbReference type="eggNOG" id="ENOG502S6TR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANKHVQY"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652050" evidence="8">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX15246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="229" mass="23218" checksum="6A7D5E82E645362B" modified="2013-12-11" version="1">MQFSTAIISALIAAASLINAAPLEKRENACASVELVFARGTGDPGIVGPPLYAALKKFVSDAVYYNIDYPAGIDFLTSAATGTAAMQKYVEARTQACPQMKFALSGYSQGVMVVHGLKLSDAAKNNVAAIAAFGDPYTLLGAAATWPINNPTSNVYRLCNAGDPVCGGGINIMAHLLYGTNPGPAAQFIAQRVSGSATTSTVAGAASSTAATPAAGNLLGGLVSLLKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9S9</accession>
    <name>U4L9S9_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 14">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_01725</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 14"/>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9S9"/>
    <dbReference type="STRING" id="1076935.U4L9S9"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDIPRPE"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="422" mass="48013" checksum="898DA93DE2ABCF40" modified="2013-12-11" version="1">MALDGSLAGRKSFKVFNQDFIVDERYTVTKELGQGAYGIVCAATNAQNGEGVAIKKVTNVFSKKILAKRALRELKLLQHFRGHRNITCLYDMDIPKPDNFNEVYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFLSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHFLGTPNEETLSRIGSPRAQEYVRNLPYMPKIPFSQLFPTANPDALDLLDQMLAFDPSSRVSVEKALEHRYLSIWHDASDEPDCPTTFDFSFEVVDDVPQMRKMILQEVIKFRHEVRRQPLPSNMIDPSVRKDSIGIPEQQWAQQTRNEAPRPHEAYVEGEQSLEDVLAGGLDAMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAF6</accession>
    <name>U4LAF6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAF6"/>
    <dbReference type="eggNOG" id="ENOG502S85Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QYWVYGP"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651810" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25955" checksum="34059786F12408B9" modified="2013-12-11" version="1">MQLTNFLIPLALAATVSAAPVDCLGKALNIFEDINCPLTSTAILPTIQQPNYAELSAPAASPSPIPTPLRVVLGHGTQNYTCSTNTASSKPVAAGAKAQLIDASCLAKYPDLLHSLPATIMSFNPKQLSEFLAKKLNIYSFNAYIGDHFFSDATTPVFSFTRSGGETIVGKKSENVAAPATVNAKGMTDGMTTDAVDWLKIAATEGTTNGCKSVYRVVTAGGKPPATCEGQESTVEVAYATEYWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBD1</accession>
    <name>U4LBD1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936578">
        <property type="protein sequence ID" value="CCX17130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBD1"/>
    <dbReference type="eggNOG" id="ENOG502T2E1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3032844at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX17130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="407" mass="45231" checksum="C7050F02227E282F" modified="2013-12-11" version="1">MAQTMFCSLKAISGRFLIICRAISMLSAVLISVGYISQYVEIRYMTIVQAAWWLGIQISLASLRVVIWMWDPEFDSVLRDRSVYESIIKCDDCLTANHLAGLRLSNMGNGGEYYHENVFTFPAALHRRLLSGPGITARKILQQAKDIVDGNELSKKTRQDLLSKPIDTWMFPNGLYSRLIGHHHQNGKRLESPTGDFSYGAALVNIRESREAPPWEEGELYNILLVFADNIATPHSSAAEWEDIADRFKFDEDESVYEFSKCMEGECHICHYRHQDVSTELISGELEGVDTSTNLQRMQKEYLKVLNWLRQHSELALSAYPKKKTPQTSKPNDSAPTVSQGRSVGDFTVNIPPEPTATGTSSSVQTGNLTSTASSTSFSNPLSASGHSATNQRAPYVFGFGKGGISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBF1</accession>
    <name>U4LBF1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_07207</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HF935357">
        <property type="protein sequence ID" value="CCX07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBF1"/>
    <dbReference type="STRING" id="1076935.U4LBF1"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWLDQPV"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="284"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="576" mass="64038" checksum="2BC3D32394053830" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBN0</accession>
    <name>U4LBN0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Transcriptional activator protein UGA3 acc. no. P26370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_11259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935630">
        <property type="protein sequence ID" value="CCX11665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBN0"/>
    <dbReference type="STRING" id="1076935.U4LBN0"/>
    <dbReference type="eggNOG" id="ENOG502S0U0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RRVQTGC"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX11665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="577" mass="63513" checksum="9FD2512D463D4561" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCF4</accession>
    <name>U4LCF4_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936418">
        <property type="protein sequence ID" value="CCX16516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="119" mass="12986" checksum="039FF3DEC6FAA5A6" modified="2013-12-11" version="1">MDTGSTKDSDPSVEIVPDNGLDSPVHPEDRLNSQDGTHATEDDEPGRVSISLADAARMFQWAMNYTPDESGIDLIDVQWWFESGDGSVASANTPTPVDSQDRVDDEDEVDSTEDELDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCS9</accession>
    <name>U4LCS9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein YEL023C acc. no. P39992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCS9"/>
    <dbReference type="STRING" id="1076935.U4LCS9"/>
    <dbReference type="eggNOG" id="ENOG502QVC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FAGNHCD"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="165"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="43664" checksum="ACF490798BB03A77" modified="2013-12-11" version="1">MSFNTSFPSSSNGVGKRKNGKPPNKLVLCFDGTGNKFTGTSTDTNIVKLYQMCDRDAKGQYHYYQPGIGTYTADESSMSRGVFGSIQRWFSQTIDNAIGTTFTHHVLAGYRFVMRYYKPGDLIYIFGFSRGAFTARFLARMITEIGLLSRGNEEIKQTYLPTFVPAATYIRHAVSIDERRLKFKVALFCQDADDCDHDINSAEQAQDIKEVWFPGNHSDVGGGWATKTKEDIQLSDVALEWMINEINSIPEPQEEKLAFNHRRDEFLKRMHAKRADAIEDSLIHDALSFGKGWNWLGVMFWWLFEILPFFKRMELINHKWANIYWPPNLGSTRDIPDCANLHPSVMERVKHADGGKYRPQNEGFFTALNAFSAQSGRSGPSAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDE9</accession>
    <name>U4LDE9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Inorganic phosphate transporter PHO84 acc. no. P25297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_05628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDE9"/>
    <dbReference type="STRING" id="1076935.U4LDE9"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKVARFQ"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="558" mass="61334" checksum="C62750A0DF00B7D6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDY4</accession>
    <name>U4LDY4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDY4"/>
    <dbReference type="STRING" id="1076935.U4LDY4"/>
    <dbReference type="eggNOG" id="ENOG502S2W9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KDQMFRE"/>
    <dbReference type="OrthoDB" id="5383703at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="2">
        <location>
            <begin position="292"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="847" mass="95261" checksum="6621F728F9E41098" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LDZ3</accession>
    <name>U4LDZ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Demethylmenaquinone methyltransferase acc. no. Q9RRT0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935449">
        <property type="protein sequence ID" value="CCX09309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LDZ3"/>
    <dbReference type="STRING" id="1076935.U4LDZ3"/>
    <dbReference type="OMA" id="WENELHI"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="71" mass="8109" checksum="0128A12045F2A514" modified="2013-12-11" version="1">MPTDEKEQDRLDLHHEIMRLAWENELHIAPLTEPHRILDVGTGTGIWAIEMADKFPTAEVVGTNLRPIQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LE81</accession>
    <name>U4LE81_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to tRNA1(Val) (Adenine(37)-N6)-methyltransferase acc. no. B2RK25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935776">
        <property type="protein sequence ID" value="CCX13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LE81"/>
    <dbReference type="STRING" id="1076935.U4LE81"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAIDIAY"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="336" mass="37834" checksum="0EBDA56A4D733131" modified="2013-12-11" version="1">MTSNNVVEDILEVDPALLLPEDDDDYHSIGYATTTESLTESIFEYIFENGRRYHSYFGVDKNLMPTDEKEQDRLDLHHEIMIQLLNGKYHLAPVGDNPQRILDIGTGTGIWAIDIAYQYPSAEVTGTDLSPIQPKWVPPNCKFEVDDAEQPWTFRPDTFDLIHSRNLNQAIASWPSVMSSMYTCCKPGGYVELAELECRAYSDDNTLAPDDKFGHFMNLLCEAMTKLGRPHASAEALVQRLEEAGFVDVQAISVKQPFGPWPKDAHRKRIGALTMMMCESGCEAYGMAPFTRVLGMEKEEAAKVCKEAAEAVRNRGTHVYSYYHVAYGRKPEDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEB0</accession>
    <name>U4LEB0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Chromosome stability protein 9 acc. no. Q06032</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEB0"/>
    <dbReference type="STRING" id="1076935.U4LEB0"/>
    <dbReference type="eggNOG" id="KOG4739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="163" mass="17974" checksum="58A84257BC29CC64" modified="2013-12-11" version="1">MSSPRQASSTGSPRKNRNDPIFHCRVCFKGLPTAASKDPIQPPFWLTSCGHIVCSDHIFPEGAPENATVKKHCCPYCEKGDISLVGVDGAEPPEGLKDYFTPATELVENLAGALKFQYDNVLRFAAHYKSLAEKLSEKLDNQKSVLLRVKDELLEARELKNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEI1</accession>
    <name>U4LEI1_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935393">
        <property type="protein sequence ID" value="CCX29957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEI1"/>
    <dbReference type="eggNOG" id="ENOG502S978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDVSYEG"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="286" mass="31655" checksum="C1CCA1CA0F480C19" modified="2013-12-11" version="1">MPILRRYVRVTQFTVLEARIFLPSPSDAAWISRNNELALVFSTIKPYVLPMLQEAKVQQTTGAARVKEQEKVEVVTDEFTASLYLTRAGTIHAVLRKDRRFEERRQQDVRDGSSAATNNRLTDEAKSPPVVIREESPDAEEMLDLGSFPEAGMQGEGVEEQDETPLFLPGLAGSSDDEGEDFRPPQARSQMGPPPPKERPAKSKPAANDDKKKLKFTTDYEGFTIYDKVLCIVITRPKKATGKGKEKEGEKGLSGGGLIEGWISMSQAVRDGNVIEVLDGDMQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEL2</accession>
    <name>U4LEL2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935398">
        <property type="protein sequence ID" value="CCX29992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEL2"/>
    <dbReference type="OrthoDB" id="10485433at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="304" mass="34977" checksum="F4136025253DC054" modified="2013-12-11" version="1">MDLPPRYESAPLEKPPSYARVIFDQVVTDRHDDANLPALEHFAYLNPITMAVVDANAAPPRYRRKSTPTSATMEPLRPLYRSSTPAGQASTNPNRASTNAGRSSAIPSRSSTNTGQRSLNPSGSPARRWPTVRTSPYISMRPESSDYLRYQNGGMLPYNNPNGNNYFHVAHENLDEPFSARAVREYYHGVSDEQLRTAILEDIKFTKLQESARIKKLEERMFQKKVKFVVFNIVYSIFLVALCFYIYYKMYPDPIPKWLSWVPPAERPGFVTYLRIMYLEHLQNGRDYTVLYEQRYPGFRTVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF38</accession>
    <name>U4LF38_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935475">
        <property type="protein sequence ID" value="CCX30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF38"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="163" mass="18225" checksum="9607564F0F7053E9" modified="2013-12-11" version="1">MVASDPPVLNPTDTYSTTLPQNLQTTDPLISALATYMAGVETMFTNLAQIQGNMEREGYPINGLAFGDSPTKYIAMAIKYGQDRELPISPQEIKDAILIERMNAFLHDAIEATKFVFSHNATGHKQVTLIYVSVTIYIENVYKIIEVIYSEETKGVWVRIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF89</accession>
    <name>U4LF89_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Uncharacterized transcriptional regulatory protein C1683.13c acc. no. Q9P6I9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_09750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935514">
        <property type="protein sequence ID" value="CCX10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF89"/>
    <dbReference type="STRING" id="1076935.U4LF89"/>
    <dbReference type="eggNOG" id="ENOG502RYZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTKNGHQ"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="833"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110668" checksum="28430DE203638688" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFG9</accession>
    <name>U4LFG9_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935536">
        <property type="protein sequence ID" value="CCX10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFG9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4431" checksum="D10C4268D586F03B" modified="2013-12-11" version="1">MVSNLDSDPITELSLVRAVRRLAAAKTLCLAGSNVVEMETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGA9</accession>
    <name>U4LGA9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Phosphopantothenate--cysteine ligase CAB2 acc. no. P40506</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936113">
        <property type="protein sequence ID" value="CCX15019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGA9"/>
    <dbReference type="STRING" id="1076935.U4LGA9"/>
    <dbReference type="eggNOG" id="KOG2728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LERYQHH"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX15019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="361" mass="40587" checksum="D016A89E6CF3EBD0" modified="2013-12-11" version="1">MSSTPSLEELPPIAQPDDELQYFETHAPPANIAQLSLEVRDFIAHHHAAHRRVVLVSSGGTTVPLENQTVRFIDNFSAGTRGATSAEYFLEAGYAVVFLHRQFSLLPYSRHYSHSTNCFLDYLSEWGRIGEGEDAAEGGDVVVKQKYRQQMLDVLRKYRRAKENKTLLLLPYTTVTSYLFLLREVAMRMQVLGSEGLFYLAAAVSDFFVPPDRMAEHKIQSGDIPGAAGEDNHAAAAVAPGPRGKKLVIDLDPVPKFLNRLVEGWAPNAMIISFKLETDSAILLYKCRQALERYNHQLVIGNLLSTRKFEVVFVDNKKNENWIRVPEAKEGEEQLEIESLIVPEVVRRHNQSIGGASIHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGB8</accession>
    <name>U4LGB8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGB8"/>
    <dbReference type="OrthoDB" id="10372938at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="314" mass="36240" checksum="077D8C0674BD5C55" modified="2013-12-11" version="1">MPLFRKDFFAGTRSQQQTPPQPPQETIHYSTLFLVAKLDLDQVKPELWENKNIVETPADRSNGKTVFDPDSHARRAQAQHNKALRQRKKDRDHRSIQPEWFQGHAQDLSRCYDEIEDVSSDLRDAARRDNWYLELLELRESRKEWEEDEHRERNQEHRERNAKQALEQAVKAVRPPEWVREHEPVLSSSASIRSVRTNNSRRISTASFASGSDNRNSMLSTTSWEPRNSMLSTRSYEARNSMLSTTTRSTARSSFMSWARSSASSPISSGLPSPILDSYEEYAEDDEEESRRHSKGKMVPSRNSAELPPPMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGK1</accession>
    <name>U4LGK1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FAD-containing monooxygenase EthA acc. no. A0R665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936161">
        <property type="protein sequence ID" value="CCX15273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGK1"/>
    <dbReference type="STRING" id="1076935.U4LGK1"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WISPFWI"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX15273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="572" mass="64465" checksum="FA96816973616FCC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGM4</accession>
    <name>U4LGM4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935572">
        <property type="protein sequence ID" value="CCX10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGM4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="138" mass="16348" checksum="3A55CC4E7F3C4587" modified="2013-12-11" version="1">MVPHSEPLKNSPDYIQSLVNTFVNATKDIKNAEKLLDEHIPRHILSDDKLHGLDSALDGDKKKREAHTRALLRHRECRNRLQVAEFARENSFEKMLEYFRQVSRGDAHLEIRDMERMRLEILPHCNDKWKECLDFVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LH33</accession>
    <name>U4LH33_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935560">
        <property type="protein sequence ID" value="CCX31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LH33"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="54" mass="6048" checksum="06349EF34910ADEC" modified="2013-12-11" version="1">MEAHPGVVTQASKVACFASLPRKLEASKMPRQEKPSSPRWTSRGRLKPEATEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHI8</accession>
    <name>U4LHI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Zinc finger CCCH domain-containing protein 45 acc. no. Q0DA50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_10684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHI8"/>
    <dbReference type="STRING" id="1076935.U4LHI8"/>
    <dbReference type="eggNOG" id="KOG1902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="339"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="467"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="667" mass="74234" checksum="033DAB8AE169A2BE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHQ4</accession>
    <name>U4LHQ4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHQ4"/>
    <dbReference type="STRING" id="1076935.U4LHQ4"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="217" mass="24521" checksum="9309AE7F12955E50" modified="2013-12-11" version="1">MGRTWIIKLLRLNGFHHLLGGRTRVASLVLGGYNAIRFQPNNVTFNLGTEQYKEIKAPLTSLTLSMTKESGIKPINNILDKPINVSINSITSYIWLPKTACEKIEKAFNLTWNEAEQFYLLDDVTYQNLKKASPTFTFTLSNGTGDVHINIPYEALDLDIALPVLKMVPQNQTVKVGQGFCNCIFYRIQTKLTIVAKPHITCYFLFAFSAFFAFENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHS6</accession>
    <name>U4LHS6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_11310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935638">
        <property type="protein sequence ID" value="CCX11716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHS6"/>
    <dbReference type="STRING" id="1076935.U4LHS6"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWYHIPQ"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FE2OG_OXY"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="147"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
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        <location>
            <begin position="589"/>
            <end position="667"/>
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        <location>
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            <end position="601"/>
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        <location>
            <begin position="608"/>
            <end position="651"/>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX11716.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="667" mass="75039" checksum="81A0C968E73A46E1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LI83</accession>
    <name>U4LI83_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized protein C1420.01c acc. no. Q9UTM5</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_11166</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
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        <property type="entry name" value="DUF3295"/>
    </dbReference>
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        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
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        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="221"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="535" mass="59177" checksum="201A2CED51BEBF46" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJZ7</accession>
    <name>U4LJZ7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Sphingosine N-acyltransferase lag1 acc. no. P78970</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_07021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
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    <dbReference type="EMBL" id="HF935352">
        <property type="protein sequence ID" value="CCX29695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJZ7"/>
    <dbReference type="STRING" id="1076935.U4LJZ7"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWYILVQ"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="153"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX29695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="464" mass="53284" checksum="1BEBEDAE757DDD6E" modified="2013-12-11" version="1">MRTTTASPGGADAATTARDAGADTTTRRVKGTRRKTIEKAQRPKKKKTQKLPETWTASLAAFLVRNQIRMSLTLIISLATTHIFCPHLRPITRKFYEISYYNESTGKYGKGLDDLYLVFFWITLFTFLRSTILDYVLLPLAKMGGINTKKGIVRFTEQAWLLVYYSVFWGVGMNLMSGSPYWLNMEELWTDYPVYEVSGLFKWYYLAQFAFWLQQIFVLNIEEWRKDHWQMFAHHIITCALISASYTHHLTRVGHVILCIMDVIDILLSAAKLLKYLGYSTLCDYAFGIFMVGWIVGRHGIYNMITWSVYRDSGRLITPACYSRASDSIIPGLEVSWPITRDTFLFKSDTVCFTDDVRRVFLILLVGLQIITLIWLYMIFRVAWRVVTGAGADDTRSEDELSDDDQDIQEEQESSGDSEELEQMEEIGEAIGEAEIRAVNGLKKKETVVDKYGRVTRSRAKRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK84</accession>
    <name>U4LK84_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_13354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK84"/>
    <dbReference type="OrthoDB" id="5362005at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="177" mass="20120" checksum="212A7BE02600A42B" modified="2013-12-11" version="1">MYGGVPHNEWLGLKHNNKPSCLLYSYGVRDDYDCAETPRGYSFISAAAPMQLRNDSGGMDEDDEKSKDVWCPFQSAAVIDAVEPMDSDMSDGQSTGDDMEIEDVNTHETMQVDQFHQQQFQQQQHMQQTAQPINFQQAAIINKRKRGSDALEQNTEMNTYQYQQMPVDNSKRVRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKE5</accession>
    <name>U4LKE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKE5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX29830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="22832" checksum="3928818A4DCE9CC8" modified="2013-12-11" version="1">MRTLATTTFPNPKISAECPHLLICINRQYCGARLPPKKPSGKGGRGLAETDEDIKTEENSAAADNDAVSVPNTLIARGGCRRSQDCDRPLACIKRVFQIRRNIPRIGAPPIGKERPEYKGRRDLDNVSEEADREVNAEYIDTMNDAEGFMSVLNDVSKPTDPLTELRIIKFNICGDKQAPCPQGQICGGDGKCRLRKLSYGGVGKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKX6</accession>
    <name>U4LKX6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935734">
        <property type="protein sequence ID" value="CCX32232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKX6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX32232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="16" mass="1867" checksum="5467900FBB4C4E94" modified="2013-12-11" version="1">MSLASFPSRRPRLMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLE3</accession>
    <name>U4LLE3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Mitochondrial phosphate carrier protein 2 acc. no. P40035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_08282</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935427">
        <property type="protein sequence ID" value="CCX30180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLE3"/>
    <dbReference type="STRING" id="1076935.U4LLE3"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YKGAIWL"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="285"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX30180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="382" mass="41476" checksum="BE5BFA87B92F3B78" modified="2013-12-11" version="1">MPSSPITRIQSTTNTAPSLETHDHTATMSLFPSSQTMNKTFPSPSDFWIASTSDKAHALSDKAKAEIAAASALAQKKTGHIEMYSPKFYAACTFGGLLACGVTHTAVTPLDLVKCRRQVDSKLYKGNFQAWSMIFRKEGMRGVFTGWSPTFFGYSAQGAFKYCGYEFFKKFYSDLAGPDLASRYKTGIYLAGSASAEFVADIFLCPFEAIKVRAQTTIPPPFSSTFKGISTVVASEGVAGLYKGLTPLWCRQIPYTMMKFASFETIVEKIYQRLPKSKSEYGKGVQTAVSFGGGYLAGILCAVVSHPADVMVSKLNQNRKGGESAGQAVKRIYGEIGFGGLWNGLPVRIVMIGTLTGLQWLIYDSFKVFVGLPTTGGGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLX0</accession>
    <name>U4LLX0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_14184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="HF936029">
        <property type="protein sequence ID" value="CCX33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLX0"/>
    <dbReference type="STRING" id="1076935.U4LLX0"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="19"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="379" mass="40374" checksum="FB6072F57BD2B040" modified="2013-12-11" version="1">MSTEGQIIKCKAAVAWEAGKPLSIEDIEVLPPRANEVRIQIAYTGVCHTDAYTLSGKDPEGAFPIILGHEGAGIVESVGEGVTNVKVGDHVVALYTPECKECKFCKSGKTNLCGKIRATQGRGLMPDGTSRFRCKGQDLLHFMGCSTFSQYTVVADISVVAITPEAPMDRTCLLGCGITTGYGAAVVTANVEKGSSVAIFGAGCVGLSVIQGAVKNGAGRIIVVDVNDAKEEWAKKFGATEFVNPTKIGKPIQDYLIEITDGGLDYTFDCTGNVGVMRAALEACHKGWGQSIIIGVAAAGQEISTRPFQLVTGRQWKGCAFGGIKGRSQLPDLVDDYMTGKLKVDEFITHRKTLPEINDAFQVMHSGDCIRCVIDMINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMC2</accession>
    <name>U4LMC2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_01304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936128">
        <property type="protein sequence ID" value="CCX15040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMC2"/>
    <dbReference type="STRING" id="1076935.U4LMC2"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRMMVLA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX15040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="512" mass="56548" checksum="3BC5E0CB8F38179D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNW0</accession>
    <name>U4LNW0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to RNA-binding protein 8A acc. no. Q5D018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_09836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCX31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNW0"/>
    <dbReference type="STRING" id="1076935.U4LNW0"/>
    <dbReference type="eggNOG" id="KOG0130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTISCDF"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="19386" checksum="B08778047C6A73D9" modified="2013-12-11" version="1">MASMDIDEIPPAQQETEGPTTTSGAFAVRSIEGWIVLVTNVHEEASEEDLQEKFAEYGDIQNMHFNLDRRTGYAKGYALIEYSTLPEAREAIKQSHNTKLLDQTISCDFAFVRPPPTSGSGGGSGGAGRGRGGRAGRDGRAGAAAGGARARSRSPGAGEDDAEEEGQVKEENAGKSLAERITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LNY6</accession>
    <name>U4LNY6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LNY6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="112" mass="13093" checksum="A1D96CFE79DB203B" modified="2013-12-11" version="1">MDTAYYQAALQERAAVRSQEQGTLGWWYQYYGIVNNCWYHPARNIQDNPKAIDPRLIPIYPKFCPESAAEPHSMTAERRDMKKKESFLHQKSALDEMMTRKRARDPNLEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP66</accession>
    <name>U4LP66_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RNA-binding protein 25 acc. no. P49756</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936391">
        <property type="protein sequence ID" value="CCX16402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="U4LP66"/>
    <dbReference type="STRING" id="1076935.U4LP66"/>
    <dbReference type="eggNOG" id="KOG2253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="134"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="4">
        <location>
            <begin position="646"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX16402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="738" mass="82198" checksum="F19A2A361002BD37" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LPQ3</accession>
    <name>U4LPQ3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein C17orf39 homolog acc. no. Q9CPY6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCX34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LPQ3"/>
    <dbReference type="STRING" id="1076935.U4LPQ3"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="309" mass="35368" checksum="D9485F14CBC1955E" modified="2013-12-11" version="1">MPTPNVTAIVEIVTIASSENARPSRLHVACPEEPTTTAHIWSDAEVGESSSSTASSPSCEDTASPRPEEGSFASRPAYRGISSFSNKIRDRDVKASTRKPEVTATSHNNPSFGDDTYSTRRIIPSYSSTFLRPGSKFTGRQLSDRSTYEVHVELKHVDMAESFLCGYLRIKGLTEDHPTLITYFEGEMIGPKHDFITKKPEWGSNERNDEAHWKRFAPFRSFKDKHEQFDYKNFAQKDHIFMRWKEYFLVPDHKVRQISGASFEGFYYICFNQVTGVIDGIYFHAKTEKFQKLQLKYVPERTFAAVEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQC3</accession>
    <name>U4LQC3_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Chromatin structure-remodeling complex subunit rsc7 acc. no. O94522</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_02655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34155.1"/>
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    <dbReference type="eggNOG" id="ENOG502R38T">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
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            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="633"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="694" mass="76562" checksum="B04507A1B4D4A196" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQN3</accession>
    <name>U4LQN3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQN3"/>
    <dbReference type="STRING" id="1076935.U4LQN3"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWRQQML"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:monocarboxylic acid metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="393"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="486" mass="54373" checksum="6EB3F78342CAEBBF" modified="2013-12-11" version="1">MAIQNTPNAVKNSQTITVTDNRTGTTITIPITNNSIPATAFKALKTVPALSGDSIDTNDTSNGLRVFDPAFLNTAAISSKITFIDGDRGFLMHRGYPIEQLASKSDFLETAYLLIYGVLPDKKQDDTWRYEIMHHTALAEDVMKVISSMRYDSHPMSVFITAIAAMGAFAPEANPALQGRDLYTANADVMNKNIIRILGKAGTVAAASMRVRMNRPFIPPRSDYSYCENLLYMMDSHSEAEGYKPDQRLVKALDILFILHADHEMNCSTATMTHVGSSLVDPYSAIAAAAAALYGPLHGGANEAVIRMIERIGSVEAVPEFLEKVKRKEELLFGFGHRVYRNTDPRSKIIREVAEMVFEACGREPLIEVATALRDAALKDEFFVKRRLYPNVDFWSGLIYKAMGFPLDFFPILFAVPRVAGWLAHWKQLLDHGNGKIWRPRQIYVGEGLRDYVPIEKREERKVENHADGVLMLPHYQSKRRLGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQQ5</accession>
    <name>U4LQQ5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_11193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQQ5"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="426"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="549" mass="62971" checksum="23799437259BC0A8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQR8</accession>
    <name>U4LQR8_PYROM</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Pyronema confluens</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX29646.1"/>
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    </dbReference>
    <dbReference type="OMA" id="CKRFTST"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX29646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="445" mass="48447" checksum="EC4EE2379FAE840D" modified="2013-12-11" version="1">MSEDREALLRKISQVAGRINRHRNQSETPSVPSYRGGAALRGRGSNHWQPPRGRGHAAWAARGGGRGRGVVYNRTLVINNRTPSTGPSGGGPASAPTAAASSSTSPTTQQPQPAAAGPGWVAKNDRHMQLINTSIYDQEIQARAKAMEKTRKEKADRKAEIEKQKLQRFLQTDQGHSNHKVDINGEQYLVTAGGSKLVRVSGNSVDTPWKAVVGGVEFQRSRNGNLVRAGLVRASRLSKLVHQKSTELCKFYTIHGRCNKAQACPYVHDPEKVAICPAFLASGSCPDGNMCDLSHDPTPHRVPVCHHFVRGNCTNQDCRYAHVRVNPAAPVCRRFAMLGYCPKGSECAERHVRECPEFDEKGECSDPKCKMPHTERAGKRRAAVAAAAAAAAELAKGFSEYSDEDEEDDNSSVVSDVDSDIVGEEDLSGNRQTDDSILKEDFISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRE5</accession>
    <name>U4LRE5_PYROM</name>
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        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRE5"/>
    <dbReference type="STRING" id="1076935.U4LRE5"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="9">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="199" mass="22545" checksum="2FC3A94DA7C8386C" modified="2013-12-11" version="1">MYGDLAQKLIQNAKRTQSLPTLPGYQSDLVRSVTREVRDLDRDVSELLAPFEGAFNPAEHPALAYTLLVHHLCMRRNKRCLLAYHRVRVQRIEELVWNGTSADDEDKGEEGNALSPEEEEYLRGFSDLLAAAKGKWTDIDLTGSLEPPRDLFVDVRVLKDAGEIQTEYGAINLTKNSQFFVKLGDVERLIQQGFLQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRG9</accession>
    <name>U4LRG9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935391">
        <property type="protein sequence ID" value="CCX29876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRG9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4697" checksum="749ACBC8813F724E" modified="2013-12-11" version="1">MKPRKMHPRKWTKIRFSSKDNTCLFLREPHQCPMPSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRK0</accession>
    <name>U4LRK0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935702">
        <property type="protein sequence ID" value="CCX31960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRK0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="101" mass="11108" checksum="2B59C4F2AF3420E1" modified="2013-12-11" version="1">MIRLHHFRSMLPPTRDPRTMVVSKAIQQRRNAVALCTSLSEWTSENTTLARGSIIFGGITLFGLTLFSIRPTPMTSNEVGNMASGIRNSTAQILTHPPNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRN8</accession>
    <name>U4LRN8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936442">
        <property type="protein sequence ID" value="CCX34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRN8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="61" mass="6579" checksum="224AA1E7B17BF79D" modified="2013-12-11" version="1">MSMAVFVPIVPIVPIVPTVLISSDSIGLCRVEVGMLSFREDNFGLCAGGQFTRSLDFGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSH5</accession>
    <name>U4LSH5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936567">
        <property type="protein sequence ID" value="CCX34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSH5"/>
    <dbReference type="STRING" id="1076935.U4LSH5"/>
    <dbReference type="eggNOG" id="ENOG502SCBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAPNPKT"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13079" checksum="557A08706CC021E4" modified="2013-12-11" version="1">MPQERLSNDQFFTKLTELLASATAANKHGVFLTQKAVNPVRDPGHSASSLLVRATDGLKDKAIRKKIATIVAPEDLETFFTQYAEVAKRNMGSLKKRDKKKKNKKKKKETVTPVAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSJ1</accession>
    <name>U4LSJ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936570">
        <property type="protein sequence ID" value="CCX34574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSJ1"/>
    <dbReference type="eggNOG" id="ENOG502S9V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="352" mass="38057" checksum="FFCFB7163A931FDE" modified="2013-12-11" version="1">MSFTPPPSLHLPSSNFVFAASTASYCLTTSRVLLCHDTHANPPYYFLPRGRKDVHEHIQSAAIRETFEEGGYRVRLVRGQHRTLQPRGMGVSEAGPAANGAETATVKSPGAAGGVYDADGKCPTCGRTTDDTKDTESSPAKLVAGYDPQTDPNAAAAASTGTKAAVVEPALPKGTKPSPASTTALTIEGHTEPFWTLLQPYPRRHHLPQSMEDIALYIASYYLAEILGPRDSAYGRSFVGKHEGGYDSGLYPIEEAVELLTRGRMFVKDGILRWSEAAAPVSGMGCTIASSGGGGRYDWEREQGGREVLWEQVLGKDTGAVEACVVWFGWECVRGEKYRRDTGERLEWEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSQ1</accession>
    <name>U4LSQ1_PYROM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935439">
        <property type="protein sequence ID" value="CCX30346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSQ1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6842" checksum="9A3C8CAC3E10BEDC" modified="2013-12-11" version="1">MELSFQTLVPTRSVFAQVKSWFIQPDELLPPSPALGLLRRNFNITITRNTPLPGYSLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LSZ8</accession>
    <name>U4LSZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LSZ8"/>
    <dbReference type="OrthoDB" id="5429879at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="941" mass="104091" checksum="70C28993E10148E8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTD2</accession>
    <name>U4LTD2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pc21g18550 [Penicillium chrysogenum Wisconsin 54-1255] acc. no. XP_002568847</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTD2"/>
    <dbReference type="STRING" id="1076935.U4LTD2"/>
    <dbReference type="eggNOG" id="ENOG502S4JN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHNDGEE"/>
    <dbReference type="OrthoDB" id="5360414at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="17701" checksum="7C6B0329258D28DD" modified="2013-12-11" version="1">MTSRTTSTSHLLSQIPLLASPHISLPSAVTLPYSYQTLPHGLPPPSTGSGAGEGYIVSPSGAVSQTPEAVQHSIHTLLSHIQSERSEAEEAWNTWERGIQERELMEKRRVAPGWLDTGVTILEPARAGGAGGREDMRAAGMVDEAQDSASTEEGNQLDQVFGKMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU13</accession>
    <name>U4LU13_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_10407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935561">
        <property type="protein sequence ID" value="CCX31276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU13"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="4222" checksum="421AC2CC7D5937EA" modified="2013-12-11" version="1">MSFRWILQMTRNLDICSTGNSVPRPRDEMIPAELWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUG9</accession>
    <name>U4LUG9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUG9"/>
    <dbReference type="STRING" id="1076935.U4LUG9"/>
    <dbReference type="eggNOG" id="ENOG502SAXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQITFAN"/>
    <dbReference type="OrthoDB" id="2402960at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="431" mass="47474" checksum="8DCCE2AD6E70E690" modified="2013-12-11" version="1">MSNPDLDDFAQTRADDLFESEIIPVAAPQEAPREPRAFRNKPKPQPAPSANAAAGAPGTPSGPSNAAPIDRLSSGGVRKPKLSEEEMAEKMERIRANDARLMERAQKAAEDESAFEVAEQQRKQQDSQRRLEQRRKQQQEVRVVRELDEEREKNRQRKLKAVQNREWDSTKTEEDYNPRGYNPRYRRGANGGVVPDQAPDANTSKWADAPDMNTSKWADPTPSETEEASGRFNTEGGRDLELQKNYEASGWGAPEDDRRGGRGGFDDRREGRGGRGGRGGWGRGGFDDRREGGRGGYRGGRGGYDNDRGNRGQFDENRGDHGGEDRGYRGGRGRKGGYEGGRGGGRGGRDGQDDRPPRNEKPKQQKEKKPAAVVADESAWPELPGAKKVDIPMASPGMGSWAEQVQAELKPAAPKEEKKAEAFVKVEGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4LUZ6</accession>
    <name>U4LUZ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Genetic interactor of prohibitins 3, mitochondrial acc. no. E7QKV3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935724">
        <property type="protein sequence ID" value="CCX32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LUZ6"/>
    <dbReference type="STRING" id="1076935.U4LUZ6"/>
    <dbReference type="eggNOG" id="ENOG502S067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="784" mass="87503" checksum="C0BED4244AF81F9B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LV59</accession>
    <name>U4LV59_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_03480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936511">
        <property type="protein sequence ID" value="CCX34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LV59"/>
    <dbReference type="STRING" id="1076935.U4LV59"/>
    <dbReference type="eggNOG" id="ENOG502S8AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="713" mass="81314" checksum="D65889011FF450E8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4LW98</accession>
    <name>U4LW98_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">PCON_01102</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="HF936058">
        <property type="protein sequence ID" value="CCX33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LW98"/>
    <dbReference type="STRING" id="1076935.U4LW98"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCASRDW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4563" checksum="8B347F65C7C051B7" modified="2013-12-11" version="1">MALRRSVFNLLSNADMVNIVVFHGGTRRADAGGFRRIGRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXH7</accession>
    <name>U4LXH7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_03702</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LXH7"/>
    <dbReference type="STRING" id="1076935.U4LXH7"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPIMREN"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="146"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="366"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="514"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCX34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="586" mass="64594" checksum="A67A54DA3E5D14DB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LXI9</accession>
    <name>U4LXI9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Putative ATP-dependent RNA helicase ucp12 acc. no. O94536</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_03722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LXI9"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LFRVCNM"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="400"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="596"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="827"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1366" mass="152113" checksum="63004E3C8B57BD32" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTQ7</accession>
    <name>U4KTQ7_PYROM</name>
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        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTQ7"/>
    <dbReference type="STRING" id="1076935.U4KTQ7"/>
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    </dbReference>
    <dbReference type="OMA" id="ADIFYWP"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651616" description="ER membrane protein complex subunit 10" evidence="2">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19282" checksum="23282C3420E7323C" modified="2013-12-11" version="1">MQPSLPRLLLTLLGLLSLVSASDITATLQAWPLSAASPTPVGSVVYNPVTLTTSTTSLKPLSLKDDELIRIGSGDSDNGSWTVTTAGSLVNGKLVLQLDAEGRVYQVEVEQGRAAPEGVVGTEVELSRVVKGATPTLNKPVVLNAQGRVPEVEKEKTFLQKYWWLLLGMFILVVGGGGGDQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTY2</accession>
    <name>U4KTY2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTY2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="12402" checksum="2B0CF3193B1326AA" modified="2013-12-11" version="1">MMDEWEEGGGKLVGEKYGGMRYGRDMLDEQDEHLLRGGRWRKASRFRKLRRLLAMCWSSHGEDRYGLRQRRAIAMSCTCTLSAPRRAVLLSWFCASGSYAESRQYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTZ8</accession>
    <name>U4KTZ8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pentatricopeptide repeat-containing protein At1g62720 acc. no. Q9SI78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935211">
        <property type="protein sequence ID" value="CCX04608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTZ8"/>
    <dbReference type="STRING" id="1076935.U4KTZ8"/>
    <dbReference type="eggNOG" id="ENOG502S3E1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PEEIMAP"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF1">
        <property type="entry name" value="OS04G0684500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="753" mass="86435" checksum="B801656D984609EB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUG1</accession>
    <name>U4KUG1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935220">
        <property type="protein sequence ID" value="CCX04918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUG1"/>
    <dbReference type="OrthoDB" id="10366963at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="507" mass="56579" checksum="AFC44712BCD18165" modified="2013-12-11" version="1">MEIPLQLMSPPTPAVLTTRHSTQTFTGPDYFCPCAEEAAASPLLSPLSDYNRYIPYRPQVAPSQQASRPYPPIPYQSTQYAPKPPTHRSRPSETSVKSINISEWHHLDNRQLIRTFTSLGKEVERFSQPFATEDEYNHDQLQSGITKLGLYQNLFRRRCEPLALVQALAKPEGRQKFVEGIIWAALTGWVFKTAVESGLRRDSVSSYQPSNRFMLDQYLSNQISAVQEPIQQLWGLISLFPQAPELRGGASTELDLRSVFILARDKAVLIHSQPAPFLVSSSSPDHDSSRPSSAGSGEFREAHGETYGSYDGASSPAFHSPNLGSSDPSSSTQTPTPSSSSLTRPTLRQKDSGFFSYSEYDYCGAEWIVSPGLYKSTNDGFVSIVHPIRWPPVELDETAEVWEPVVTHSWPPRMSVEQPRQEAVDRDRGFWGGLLAWIWGVLVTVGGWFKCGARGRKGYGELRQQRERGIREAVANSGTVAYWHVLQDVKVDIIDGASRGKQVDMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUX0</accession>
    <name>U4KUX0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
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            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8814" checksum="A2796F0A40B3820E" modified="2013-12-11" version="1">MKSKQSGIYQVLINLWTFFHSFPSSFFLHTFLPPIDIHRQNATNHKHHLAHHTDPKTESQRPNIETSEYLNNADT</sequence>
</entry>
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            <fullName evidence="8">Similar to Protein spt3 acc. no. O14311</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">PCON_05320</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 100304</strain>
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        </source>
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    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX05733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="315" mass="35927" checksum="C35CDBC9BE2DDE0B" modified="2013-12-11" version="1">MAEKDKFKYRVEIQQMMFVSGETGEPSPETTGIIEEMVRGQVIEMLLQCTQLAARRGSRSISTDDLIFLIRHDKAKVSRLRTYLSWKDVRKTAKDQDPAGGGGAAEPGDLMEEAAANIGSGPAQMIKQKKTKVGLPWEVSSFFAETVPEREDDEDEDELEANQATLQRLKNADERTRGMTKDEYVHWSECRQASFTFRKGKRFKEWAGFGNVTEAKPNDDIVDILGFLTFEIVQTLTEEALKVKEQEDAVQKEQSMRNSKKRKREEFLFHAQEGRTPIEARHVVEAFRRLQTPKPKSRAMRNYSGGVMKTRLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVZ3</accession>
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        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_05114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the THOC2 family.</text>
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        <property type="protein sequence ID" value="CCX05527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:THO complex part of transcription export complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
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        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="139"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
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            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
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            <begin position="1134"/>
            <end position="1431"/>
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        <location>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
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            <begin position="399"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
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        </location>
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        <location>
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            <end position="1482"/>
        </location>
    </feature>
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            <begin position="1512"/>
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        </location>
    </feature>
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        <location>
            <begin position="1555"/>
            <end position="1568"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1891"/>
            <end position="1901"/>
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    </feature>
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        <location>
            <begin position="1936"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1946"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2057"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2179"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2210"/>
            <end position="2283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="2299" mass="260557" checksum="849D488D34210FCA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW82</accession>
    <name>U4KW82_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UPF0589 protein C32H8.01c acc. no. Q9C0V9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935277">
        <property type="protein sequence ID" value="CCX05948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW82"/>
    <dbReference type="eggNOG" id="ENOG502S7NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYVCPAH"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="190" mass="22380" checksum="0F49855FC0B037F2" modified="2013-12-11" version="1">MALKLPLNHYTHRIIADASAAKKCWVCEMVPSYRMVTSVLITQDEPGYYRDFFYVCPSHLKDSQFCTPIGPTPEELKKAADEKLKKELEEEVKKEYEEKMKRKKEKEKEKKDGDKDKKDEEKKGDEGDKKKDGEEKKEDEKPVTGKFKLSSRFYDTRMNRIRQQEIQKRNQEILRNPMAFPSVPTRNPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWE9</accession>
    <name>U4KWE9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Uncharacterized glycosyl hydrolase YIR007W acc. no. P40566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_05023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWE9"/>
    <dbReference type="STRING" id="1076935.U4KWE9"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEFIPPW"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="680"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX05436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="813" mass="90948" checksum="FC2869A02B126745" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXH3</accession>
    <name>U4KXH3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_05777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="HF935281">
        <property type="protein sequence ID" value="CCX06190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXH3"/>
    <dbReference type="STRING" id="1076935.U4KXH3"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX06190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="326" mass="37791" checksum="2F1BEDEEF5E2FE25" modified="2013-12-11" version="1">MPFSHHSHSGQFCMHAKDTLEEMIQEAIRRGMKVFALTEHAPRDQMVDLYPEEVRAQQTPFDLFNTFLQFYNTALLLRAKYSSQIHLLVGCEAEYIRPTSIPLMRELCAQFRFDFLIGSVHHVNTIPIDFDKELYQKALLSLGPDATEDMLFEQYLDDQLIMLEEVKPAVVGHFDLIRLMSDDPKRMMSTYGERVWAKVLRNLEAVKFYGGLLEMNSAAIRKGWDTPYPGRDICETWISMGGRFTFSDDSHGVFQIGLNYHHLLAYCQSLNLKEIHYLIKLPMGEMAVDVLDACAVRALSLEELVKHPFWEMDREERKNNEQEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYL7</accession>
    <name>U4KYL7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935305">
        <property type="protein sequence ID" value="CCX06680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYL7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="208" mass="23244" checksum="9EF2A5904534DEE2" modified="2013-12-11" version="1">MNETNLVFLTDTEYPGHGHSSRQTSAPETSDESGCDTQPQSICRQGQKQTPIGPSAIDNIKVERKDDFEKEKLRTSNGHVNGNGRIPPQTTESNSMPEAPSMTDKYSYQDSIDDEDCTSSLNTSKPKLRASTARRLGNLSDFSKKIGLHNPKLPQWNLQDCLAAYSVPHSQDHITNGFNLEYISSDYVLDLADFWDPFPDIDECELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZ26</accession>
    <name>U4KZ26_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="HF935363">
        <property type="protein sequence ID" value="CCX07695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZ26"/>
    <dbReference type="STRING" id="1076935.U4KZ26"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYGHMFT"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="439"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX07695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="495" mass="56223" checksum="C18E161AD3F2DF1A" modified="2013-12-11" version="1">MPSLGGFLKKKKKEKDSLHGRKDSSHSAEQRNNPSEPPTPTTSSSATTAHSFQASTTHRSSASTVPPSNPSNPAINEPMALVSERPMIPEQQQPQSYPSQPQHQQHQHQSNISSLINPPQPNDYQNNTAQQYAASGHVSGTQREVDGAADQQQQQQQQQQQQPQQSQTQAVRSTKGKYTLTDFMLQRTLGTGSFGRVHLVQSRHNLRFYAIKVLKKAQVVKMKQVEHTNDERKMLQKVKHPFLITLWGTFQDNKNLYMVMDFIEGGELFSLLRKSQRFPNPVAKFYAAEVALALEYLHSHSIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVSSKGYNKSVDWWSLGILIFEMLCGYTPFWDGGSPMKIYENILKGRVKYPAFIHPDAQDLLQQLITPDLTKRLGNLLHGSDDIKNHQWFAEVNWERLARKDIEAPYVPPVRGGVGDASQFDRYPEDSEDYTKNDGIDQYGHLFQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZU4</accession>
    <name>U4KZU4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Nitric oxide synthase-interacting protein acc. no. Q9Y314</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_06874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935349">
        <property type="protein sequence ID" value="CCX07285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZU4"/>
    <dbReference type="STRING" id="1076935.U4KZU4"/>
    <dbReference type="eggNOG" id="KOG3039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PCVTKFM"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000673">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX07285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="391" mass="44092" checksum="43F7D9198EA2130D" modified="2013-12-11" version="1">MAHSKRNTSLAFFTSYERSLLKSDYGLQRTRLSRDSFKSFDSCNLCLERCRDPVSCPNGDLFCRECAVENLLAQRKEIKRMQMELDKRIAEEEEFRKEEQAREDQERVKRFEEVLNGLEGGRKKTAVNTDDVEEGLTAQGKRKFELDEEEIARMEGEERKKARAALEEEKVNLQILFTTDFPNTAALQREQTHFLIDQKLTFKQKKDPTKNLPSFWVPSLTPSIKDTDIIRKPPKLNPVCPASGKDHIHYYSLKGLVSVKFTELEEEKTKHGDPQRICPSCKKVLSNAVKAMLAKPCGHVVCKPCADKFMTATNDDPHDQTEKLVQCYVCDAVLTDQSSGEKGAKGSRKGKKEKGKGEVKPGLVQIQSDGTGFSAGGGNVTTEKQGIAFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L067</accession>
    <name>U4L067_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_07148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935356">
        <property type="protein sequence ID" value="CCX07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L067"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="2761" checksum="7AEB585A5960C0B9" modified="2013-12-11" version="1">MFSGVFCSLSLFLFLFTPSFTKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0B4</accession>
    <name>U4L0B4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Retinol dehydrogenase 8 acc. no. Q9NYR8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_07237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935360">
        <property type="protein sequence ID" value="CCX07648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0B4"/>
    <dbReference type="STRING" id="1076935.U4L0B4"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNEPRVW"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX07648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="316" mass="33047" checksum="640ABF3B3EDF1A9E" modified="2013-12-11" version="1">MSTETPPPAQKHKTYLLTSALSPLGHALSLHLLSLGCNLAACCTRTELSSPLLPALRDAGSNSPNGSRLIILELDAMSPSTVQCALATAATTFGRLDVVIHTGIPSFLGALEEMSATDTVSQFEIGYFGRVNVVKSALTVMRKQRGGHIVVVTGLTGAMGTPGMSLRCAADHAIEGLLDGLAYEVAPFAVRVSIVQPSVEVAVWGGGEVRVAKEMGEYEGVEQVKMIRGMAGRVLAGEELSDTVRILAEIGGSENPPGRVTVGDEGVEIVKERLKTLSEELEEYLEASLGADIMAPPGVGGTGGRMRPVAIGELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0E3</accession>
    <name>U4L0E3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935361">
        <property type="protein sequence ID" value="CCX07678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0E3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="186" mass="21029" checksum="4C6EB90E53354CEB" modified="2013-12-11" version="1">MKKIWQEEAGDIEGLDTCGYLRLSYGRAHCLGRKQHLMYTKREYVPQSRRCLHAIFHGLSFENLPTQCQPLSEIRGSSFPIFENVGINKCSLQKTTKELKPEKSTQEKHKPGIHPKKPVLNRTRHRAPCHLQLGTSAVSTHGLQAIHFDNKPTYGTSPFPSLPSVAGQDMVEMVLPSSSRQIWVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0F3</accession>
    <name>U4L0F3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PCON_05076</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 100304</strain>
            <tissue evidence="20">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L0F3"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
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            <begin position="28"/>
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            <begin position="61"/>
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        <location>
            <begin position="1352"/>
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        </location>
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        <location>
            <begin position="1390"/>
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        <location>
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        <location>
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        <location>
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            <position position="874"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS52040"/>
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        <source>
            <dbReference type="EMBL" id="CCX05489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1666" mass="185680" checksum="CF86E2D632B88ECB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0F8</accession>
    <name>U4L0F8_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to CTD kinase subunit gamma acc. no. Q9USJ8</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">PCON_07282</name>
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    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCX07693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="AREGMWA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ctk3_C"/>
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        <property type="entry name" value="Ctk3_N"/>
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        <property type="entry name" value="ENTH_VHS"/>
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        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
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        <property type="entry name" value="CTK3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="266"/>
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        <source>
            <dbReference type="EMBL" id="CCX07693.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
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    </evidence>
    <sequence length="314" mass="35827" checksum="7C4629028944772C" modified="2013-12-11" version="1">MDAFQCRLHFTRLISNLTASSVAAKQCAQFALKNRDVDEDLFSVILEQLSSKDCTMNTRINILYFIESLCDQSLAASYTSYIKMIQRDLSLIIDAVAPDDQVGAANAETARKVLHSLHTKSIITTSVLEKLVSQLSEREKNHKNLDESDDDEYAEEEEHTGDESSPASRPGKRRHFDETLIQQRMEEDRERHKRLRENIWQIPPGPGNEDWEFQKAWEEAESDLNSDDFEIMREENEILAASTAASGRWGAGMVVGMMVVVVTGTLRKRFGNPKRKKRGKRKKWKKGKKGKKGKRGKRGKKGKKGKKEKKGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0K0</accession>
    <name>U4L0K0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ATPase get3 acc. no. A7EHP6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_07866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935407">
        <property type="protein sequence ID" value="CCX08273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0K0"/>
    <dbReference type="STRING" id="1076935.U4L0K0"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX08273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="335" mass="36948" checksum="631BE4F311BABF41" modified="2013-12-11" version="1">MSVAQVDADLDPLEPTLQPILEQTSLRWIFVGGKGGVGKTTTSCSLAIQLSKVRESVLLISTDPAHNLSDAFNQKFGKEARKVDGFDNLSAMEIDPSGSIQELLESADGAGAAGNPLGGVMQDIAFSIPGVDEAMSFAEVLKQVKSLSYSVIIFDTAPTGHTLRFLQFPTVLEKALGKISQLSGRFGPMLNGILGAQGAPQMEEMMQKMESMREVIGEVSKQFKDAELTTFVCVCIAEFLSLYETERMIQELNSYHIDTHSIVVNQLLFPTQGSTCDYCNARRKMQKKYLEQIEELYEDFNVVKIPMLTEEVRGGEKLRNFSEMLVKPFEPPAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0U1</accession>
    <name>U4L0U1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0U1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="36" mass="4167" checksum="1D73889125B83344" modified="2013-12-11" version="1">MHPSRQPYSPAATYDPRTFITTLLPHNISVDNFQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2T0</accession>
    <name>U4L2T0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935295">
        <property type="protein sequence ID" value="CCX06553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2T0"/>
    <dbReference type="STRING" id="1076935.U4L2T0"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="225" mass="26414" checksum="0A6CC9BF172326D7" modified="2013-12-11" version="1">MASLTASSSRPLHSTPAVPNLPDSPLAKFFAEYHKFDYNPFKNAALEFQRLSKEYRWLWGKILPGDNDYVKQQKIKYHNERTKFFQAFQQEFNQVFDYGYLCELFEIPVPEREGGANLVLRKFNVNIFDLHSYEHALRNGLKAEIVNCEPDKDGNFELPDDEDVFFLPNFSTEEQLATYSLKNFLIYPKDLVNDEGALRFMLRHILDPEKVRPGENSYGYQEMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2T9</accession>
    <name>U4L2T9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_01957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935200">
        <property type="protein sequence ID" value="CCX04380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2T9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="166" mass="19113" checksum="2590FF6A0565C048" modified="2013-12-11" version="1">MISTNFKVPRAKLSFVDRIRIETIFSPGNSPYMQVTCSDKGTHLKVFLHDLTAHDLKKRAVVDAVLTQRFEKLPIDRVLTAAYRRASFASWMPTHYPQAVLACKMRTVQASQQTACRLWGPVSHFLLDRDNINGLLLEPNVYPLWGYHDHLGYSQRQIFLELLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2U5</accession>
    <name>U4L2U5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935298">
        <property type="protein sequence ID" value="CCX06568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2U5"/>
    <dbReference type="OrthoDB" id="5473314at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="136" mass="15248" checksum="23877196917975A4" modified="2013-12-11" version="1">MPEQVTDQTKAMEDGYIFREKPLKTIPNGIIQVSQAKADKTGNCLSDGPLREDEGSCFLYVKFTNLAESVFGLSAGRLKYLKGTKSNFLSCNGTSFSDKQRFSNRWEKEASQKDLIYILSGAEGDYVSDTVYYIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Y5</accession>
    <name>U4L2Y5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935493">
        <property type="protein sequence ID" value="CCX09720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004650997" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="6907" checksum="7A8C4774EC7621C0" modified="2013-12-11" version="1">MKFNYLIVILPVLASGVLGTAIPELEDASALACQNRGQNCNRFQRCCKGLKCTVKQGFPFKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L342</accession>
    <name>U4L342_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935496">
        <property type="protein sequence ID" value="CCX09780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L342"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="6611" checksum="6804025CC119D5BD" modified="2013-12-11" version="1">MTFLVLTSVGCSTARIRNILRCLLSPPADLRQEIRARQPPEAQFGELLRPGIFETTPGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3I4</accession>
    <name>U4L3I4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935553">
        <property type="protein sequence ID" value="CCX10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="2753" checksum="2DCFBE30D30FC62A" modified="2013-12-11" version="1">MTPGESSRVVNSPYQNPFVIARSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3R7</accession>
    <name>U4L3R7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Uncharacterized RNA-binding protein C25G10.01 acc. no. Q10422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_10285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935554">
        <property type="protein sequence ID" value="CCX10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3R7"/>
    <dbReference type="STRING" id="1076935.U4L3R7"/>
    <dbReference type="eggNOG" id="ENOG502RY2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RAKEECQ"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="89"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="330" mass="37230" checksum="0B386F1FDDE4978B" modified="2013-12-11" version="1">MDYENESRGYDDGESRDQYQRDDRSMSPRRRDSPRRERNRSASPRGLDRAAPAERSDDRRPADDMSNASERGGDRRGNGNGDSATNTGTNLFVTGIHPRLTEDDVMRLFAKYGEVEKCQIMLDPHTKESRGFGFVKMSTLEQADGAKEGLQGETFEGRTLSIEKARRSRPRTPTPGKYFGPPKREDDFRRGPPSRFRDDRGPPRGGRYYDDYDRRGGGGYSSRYDDRDGSDRHYRSRDPRDDYGGPPRGVDRYASREDRYGGSGGARGEDRYSSRGGDDRRAPRESYAYGDRDSGYSRAPPADAPPRAPEGGRSYGGGYEDDRSGGYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3T4</accession>
    <name>U4L3T4_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_06555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935329">
        <property type="protein sequence ID" value="CCX06968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3T4"/>
    <dbReference type="STRING" id="1076935.U4L3T4"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX06968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="124" mass="13909" checksum="790C82079E3AD285" modified="2013-12-11" version="1">MKILTTNYITCAVKACKTSSNAFPLQFRDAELVQEELELNEEFIKNILPRIEWPALVQTAASLGFTTLPSTKPEGDLDEQMIKDLHTLLVETQVISGKLVCGNCQHEYNIHQGIANFLLPNHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3X6</accession>
    <name>U4L3X6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935330">
        <property type="protein sequence ID" value="CCX07008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3X6"/>
    <dbReference type="STRING" id="1076935.U4L3X6"/>
    <dbReference type="eggNOG" id="ENOG502SRND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CIPEWAV"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651637" evidence="1">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="261" mass="29697" checksum="554E881576236201" modified="2013-12-11" version="1">MKLFSTLLCLVPAALAAYDSIPGSMFNNDPAQAARQACPFWFFGRSLNREPCYPESAVVNGGPHPGTPVRSDPSPGYGCPSPGHWSGTYSNGNPFPTYYNVKYCPGDQSWRINYNLYFSHDGMSGNGHRHDWEWVAVIWKRCGGSDMWCRNRLVRSFHSTQKSNNWSGIQNTINGKNELRRLGDKNKHHPLIYVGAFKHAMFDTRKTSMNVIGADELEFRSNDWWYFSQDWLVPGDQINRNWNYGAASSTPPKVWDDLCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4E2</accession>
    <name>U4L4E2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935336">
        <property type="protein sequence ID" value="CCX07173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L4E2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="150" mass="17706" checksum="0A24F3A32AC000E5" modified="2013-12-11" version="1">MSYNRYQLRSSKAPGNSVSHTGLIPRSDPGWADLHRQYTESNNQYYEQQDYGIHHSDTTVREEQWRDPGWQYGQANNQYYEQQDYRESFKDDYALSQDAEIQHSDPRVREQQWKDLGWQYRNSHNSGGNCSKSSGNGNNSGARRYPWEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5K5</accession>
    <name>U4L5K5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5K5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="60" mass="7281" checksum="0D8BFBF346B07C56" modified="2013-12-11" version="1">MKWVDEDIYKFNTTFKLTLTSYFITTLYLGPELDRKVRGIHQNFVNCLRQLSRRPKNWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5P0</accession>
    <name>U4L5P0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935369">
        <property type="protein sequence ID" value="CCX07736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5P0"/>
    <dbReference type="OrthoDB" id="2526946at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="152" mass="15947" checksum="F3AA66334676B09D" modified="2013-12-11" version="1">MQIVYNGKNLSSISVLIRSVAMGRSITLNRWVAIGGRVAIGGRVAIGGRVAIGGRVAIGGRVAIGGRVAMGGQVSLSRSVARLCSESDAKFIQNMGSLVVPWTIADNIQATEPAFNAHTGWCLALGGYQRQTLNTWVGQRVNSLGCHLLMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6A9</accession>
    <name>U4L6A9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6A9"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9847" checksum="8A9E9A6BF7694B91" modified="2013-12-11" version="1">MEFRELLMEAASGEKVGYRYHISGIISEIMQSWDELLDNIELPPSFHRSSTSCHDPSGCVVSLPFSYLLVHISSHFFSSLCPPLIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6G3</accession>
    <name>U4L6G3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Eukaryotic translation initiation factor 4E type 3-A acc. no. Q6GR08</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_11659</name>
    </gene>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12065.1"/>
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    </evidence>
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        <source>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Gabaldon T."/>
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            <begin position="13"/>
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        <source>
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</entry>
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                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            </authorList>
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            <begin position="1"/>
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    </evidence>
    <sequence length="821" mass="92913" checksum="2DA50D8239AAAAB5" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <dbReference type="PubMed" id="24068976"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 100304</strain>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="449" mass="50445" checksum="9F7AE89FECD9D9EA" modified="2013-12-11" version="1">MVNVPKTRKTFCKGKTCKKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTVCKTKAQLSLKRCKHFELGGDKKTKGAALKPYATKTQHGSMAPPPVEPVIHLGIGTDAVNSFEDLSGLSSKRSSKAGTPNNEFENPYDVLIDACENDPAQIQKAYQTHRITRNANQRARLTASDFPGVTVDPILRELEYLRDNSAVIPAFPVGHEKRHESAIDPRNCLVFWARPTVAVMDLIGGVQQRLKRFAPDLWIMPRDNLHLTVLEITHSTTEEFVATLVERMRPALQGIVDHPRNKNNRARLVKPLLSFDAAALAISFAPAEDCDYTYHHLRRDFYTLSKEAGVGVTSRYVVPSAHVTIARFVTSQDHEEAGVVSREKMKAWMNLVWEINAELERWTGEWIVGEERGLDCRVGRLWYGGGETVVQADGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7C2</accession>
    <name>U4L7C2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to N-terminal acetyltransferase A complex subunit nat1 acc. no. O74985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935853">
        <property type="protein sequence ID" value="CCX13545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7C2"/>
    <dbReference type="STRING" id="1076935.U4L7C2"/>
    <dbReference type="eggNOG" id="KOG1156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEMRADY"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX13545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="840" mass="96218" checksum="9F6CD5DDF0B182D4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7I0</accession>
    <name>U4L7I0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7I0"/>
    <dbReference type="OrthoDB" id="10514915at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="305" mass="34190" checksum="031884CFB9E6428D" modified="2013-12-11" version="1">MSTPSSYSPWPRPANDMTYPLPFCRKLRSPGKSEEEISEILRLAHERSLRTERFINDATGVSTGTTIMPNKEYGPGGGAHNSARQDFWTCLVSALFLAPITEFDSLGMDKVDPKNGQHHLVVWWSPEENRPGTMYDIFRVIHICNEGDIDDHIKSSMQTFLEWVAAEKTFQGCFILISCISRVALARVSKNSAGEIKVTYAGKSGQLDVVVLLSRAFIIQLCGMMEWLENRDIYPAKFTEPGHLEYLGLLQAQRQSLAPQVNSGRIASGPLPEGSNREHLRIIAARAADVWTEILVREQLKDDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7Q2</accession>
    <name>U4L7Q2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to 3&amp;apos acc. no. P36599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935280">
        <property type="protein sequence ID" value="CCX06164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7Q2"/>
    <dbReference type="STRING" id="1076935.U4L7Q2"/>
    <dbReference type="eggNOG" id="ENOG502RFKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSAVWRE"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="301" mass="33576" checksum="D20A2A0D500A7755" modified="2013-12-11" version="1">MKKHTHWGRKSTAGLEGIESAQVLKERWCVVDSAVFFIRDKETGAEAMMWGDVEPDSVSHDPRNSAVWREAARKIVMGSLRAVFIECSYDDSQPDSCLYGHLSPRHLIAELEVLAGHVEDIKAAEAKGRQEKLKRKRASADLSLESVSEEGERSERGERIERRKRPACGLEVPYEGPGNSCDGRDPCNRETPPPTDSGWETDMSDISPKCRPVSRSELSEIPRLELPGMAPIYGVPVSATTEKREWKNLLKGVKIVVTHVKDTMTGVDVAGKVLEDLKKLEKDTNLGCEFLLARQSEGIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7U8</accession>
    <name>U4L7U8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_12816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935790">
        <property type="protein sequence ID" value="CCX13223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7U8"/>
    <dbReference type="STRING" id="1076935.U4L7U8"/>
    <dbReference type="eggNOG" id="ENOG502RXHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX13223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="412" mass="46190" checksum="3310F3A0D34450FC" modified="2013-12-11" version="1">MHLLINTMVSSGFLCSSLQFDIILLYPQSKVLPFEVISNGKINGLLRYIFYKISSFSFITGFHLLSYLRTFRCYISQLKRRSLFLLEIEVFGHTIFSRQVYLSRIQPAMTIISIPLFEVGCQGSGYHLRNKPGQLQRSHLVQQQHSGLSVAADLSSVTHGTLTSEGDQAMLIVIDFSFFAHRNKRFKAARIDMLFSTDDQSSEEDSDESDPVIVCKISPEGVVNTNSSTEQYEKSTTKRTSADLGISGIPVKIGVARETVVTTTSEHTAFAEVIGRKKIHGRSHGEHNMAQWSIKENPTLKTGITSSFQVAILLNSPPDVRFSATIEVTTDVGGIYGAYDSIRKFFGKDKVDPVKFGRKRQRVNMGEKPEALDINNMDCFDLKTISMIKAKDEEQSVSSGQYCFHLLFNYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L7W4</accession>
    <name>U4L7W4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935448">
        <property type="protein sequence ID" value="CCX09268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L7W4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX09268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="45" mass="5281" checksum="F3E22644C498E3DF" modified="2013-12-11" version="1">MYQLEILRGDLRDLLANGLKYNKSSVISMTLLYRCTSLPKSFYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L898</accession>
    <name>U4L898_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Woronin body major protein acc. no. P87252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_09125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935469">
        <property type="protein sequence ID" value="CCX09532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L898"/>
    <dbReference type="STRING" id="1076935.U4L898"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEEPCVV"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A-like N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="1">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX09532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="198" mass="22065" checksum="7664C894DC732419" modified="2013-12-11" version="1">MGKYDSHSYEYEASHAGHNYPDEHGSVSDAAYKNPTYKSQAISSVHTPKASTFTIPCHHIRIGDLVILQHRPCQIIRITTSAQTGQHRYLGVDLFTKQLHEEPCVVSHPSPSVVLHSLLGPVFKQYRLIDIRDDGKLVAMTETGEIKQGLKVVDQGHLWSRLKEAFGRGSGSVRVLVISDHGKELAVDYKVVHLAHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8D3</accession>
    <name>U4L8D3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Probable Rho-GTPase-activating protein 6 acc. no. O43027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_09226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935477">
        <property type="protein sequence ID" value="CCX09633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8D3"/>
    <dbReference type="STRING" id="1076935.U4L8D3"/>
    <dbReference type="eggNOG" id="ENOG502SAYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="257"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="949"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX09633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1064" mass="117448" checksum="BDE42AC42D6FECA6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4L8H1</accession>
    <name>U4L8H1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Protein LTV1 acc. no. Q10191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_13315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L8H1"/>
    <dbReference type="STRING" id="1076935.U4L8H1"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TAQHFTL"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="433" mass="48981" checksum="9099F41BD3529B6E" modified="2013-12-11" version="1">MAPPKGTSKKWIDKKSAQTFQLRYRSQADPLINDEEASDFVFAQVEAPNTKIGTAAANPNVKTMKDLHEELGDELKGRRKNEGEASLYGIYYDDTKYDYMQHMREMGGSTEAVFIDAPSVDKQKGKKGKKTLDMALRDEELEPKSTVIRIPKEMMQSENLVKKTYQDQQNIPDAIAGFQPDMDPRIREVLEALEDEEYVENDEDLFNELAQAGEADEDDFFDQEFEEEDDDGWASDATEKPTQPAYVASSKDKEAAPKAEVKEGEEGQGDEWMKEFSKFKKAQKKQRFADDDDASSFADTMSFGGSSAFTAGSISVSGRRRRRREKKAGAATASSGYSMSSSALFRTEGLTLLDDRFDKIEEEYNMDDEDEDDEGIVPETRKDFDSIMDEFLDGYTMTGQRPSTHRIKRGKYQSGLDQLDEIRRTLGNTKIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9R1</accession>
    <name>U4L9R1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_02367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF936265">
        <property type="protein sequence ID" value="CCX15908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9R1"/>
    <dbReference type="STRING" id="1076935.U4L9R1"/>
    <dbReference type="eggNOG" id="ENOG502S5MV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTEYSKD"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX15908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="399" mass="43598" checksum="50B18B6CD8D58C1D" modified="2013-12-11" version="1">MSFNRRAKPRRIGAESASEDEASSPAVVVKKPTAKPAKSKARKIITADSGSEDETVVRKPTPKSKPASASSTPKPKAAKLSFGAAEDDGETEAFTMKKSNLSRKAMERNAARVVGMEVRTAEHVSYSAEALAALRQEQAAAPITEGEELAGDDIDMLEGATIVSADEDEGAGQLMRMDDDSTPQIMDPAYVRVMKERRAARAAAGKHGSTAEDFISLTANGDNQLVKSAKKSKKESRLVKDDFNDMEEIENYAEDAGALLANPGSKTARREEERQRKAQIAEIIAEASDISEDEDWQKEQIRKGVFTEAGPGIDGELEALAKNPPVAQPLPDVGEVVRRLEGMLKGMKLRKQQTERKVEELLREKKEIAEREGMVQSRLKEAGEMYEKLKAESGVQERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9R7</accession>
    <name>U4L9R7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_10056</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HF935543">
        <property type="protein sequence ID" value="CCX10462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9R7"/>
    <dbReference type="STRING" id="1076935.U4L9R7"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRGWDYK"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX10462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="457" mass="51013" checksum="BA3C177AA870D16A" modified="2013-12-11" version="1">MASSSSNVVGVHYRVGKKIGEGSFGVIFEGMNLLNNQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRRFTIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGSKAANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTAIKDLCEGFPDEFNQYLSYVRNLGFEDTPDYDFLRDLFTQALKNSGEVEDGEYDWMKLNNGKGWEAVSKSHYHQTHSPNHATTAGELRHVPPAQVRGQQPSGIPSGRLNAPQPPPPSPGKAMGMKRGDGRSAPSNSPQTKRPNGQAGGLQQQGQGTPTTSTQAQFQASATNLPPPTRGQSPQVLNQQTSQSRGNPDDNTNKKTTWQKIQAVFCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L9V7</accession>
    <name>U4L9V7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_02441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936282">
        <property type="protein sequence ID" value="CCX15969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L9V7"/>
    <dbReference type="STRING" id="1076935.U4L9V7"/>
    <dbReference type="OMA" id="IVNIRMT"/>
    <dbReference type="OrthoDB" id="5372266at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="41"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX15969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="327" mass="37540" checksum="F39E4631119CC779" modified="2013-12-11" version="1">MGIGAHDARMFFVGCVVIQSIITLCLPLRFFLLRKGWRKSSMMAMWSDAFFMFGWLIMMGWGWFDVYLVAMEVAVREKATTQLEIDMFFNTELMAKVYFTNVFIVITAIWALKAAFLCMYGDLYSRIVNIRMTAFHFTVGYVFACFITLIVCALLECRPISSVWDMTNAENEPTCSPFYSYKFQLTMLILGIITDVLLMALPLHILAQMTLTAPEKRGIAFIFLLALISIAAILSRFCILNGQGVFESLGWKNISQYYWNGFLTWLEIMLVEIAFVLPSLRIALVSRKKKRSSGGGDVMMISLVEEDRSDVLADREDAEVEHWRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA50</accession>
    <name>U4LA50_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA50"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7121" checksum="3845CA24D979D281" modified="2013-12-11" version="1">MPSQLTPEVGKLPKNIMRLLHKSRANTRERALRGGLKKHPSDPKFTESLELLGFAKLRNQDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAH7</accession>
    <name>U4LAH7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_03081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936416">
        <property type="protein sequence ID" value="CCX16438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAH7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11620" checksum="4FEC7FCD151F0DE3" modified="2013-12-11" version="1">MRTYSTLVWSPTIALDKLRYSSGGGRHVSLGKILWAERDPDDKNLGEAVNWVFRREFDRASKNALVHGLVQRGYATYSPEKGVWITTVLTGSGAKIREVNAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAN6</accession>
    <name>U4LAN6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ankyrin [Exophiala dermatitidis NIH/UT8656] acc. no. EHY59712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_01684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936165">
        <property type="protein sequence ID" value="CCX15409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAN6"/>
    <dbReference type="STRING" id="1076935.U4LAN6"/>
    <dbReference type="eggNOG" id="ENOG502SAX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYDICAK"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX15409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="347" mass="39544" checksum="CCD78721A53D2AC0" modified="2013-12-11" version="1">MDPFTLSTGVAGFLSLALEISKILGAYISDVKSARKDSQGMIKEVDNLCHVLDQLVQFLRNDAKRNFEPTSALRLVINSCQEQIEDLYKRLGKIGRVQNKAVEIIERMKWPFRKDEYQGIVAKLHRFTQTFQFSLQISNCEILSKSASNVLSVLEDNQNKLRESISVMNQLHIATDEIINLQNKQMTVISLVMEAVLASSETQDKILYGVENLNDKLDGSQKLQELLRWISPLEPQMRHYDICAKRLKDTGTWFLELEDFRKWRDGNKAEQSLFGCYAIPGAGKTVMSSLIIDYLSCGPDKSICIAYVYCEYRDKENQTALNLVGAFLKQAIDSKRAYSQTVLLNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAV6</accession>
    <name>U4LAV6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoglucomutase</fullName>
            <ecNumber evidence="5">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_02857</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the OSBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="5"/>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAV6"/>
    <dbReference type="STRING" id="1076935.U4LAV6"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="20">
        <location>
            <begin position="186"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="21">
        <location>
            <begin position="299"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="839"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCX16261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="914" mass="100790" checksum="28F583F52C70E9E8" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LB28</accession>
    <name>U4LB28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to NADH kinase POS5, mitochondrial acc. no. Q06892</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_03362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936492">
        <property type="protein sequence ID" value="CCX16663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LB28"/>
    <dbReference type="STRING" id="1076935.U4LB28"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPKYQES"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX16663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="431" mass="47443" checksum="E958DF03610B8F5F" modified="2013-12-11" version="1">MRARTLPRLSRRRYFSSSASRQEVLSINVLPDRVHPLYAKLNDGSHLLSLSWKEPPRNFMIVKKPGVDSVGDAMVEFINHITATYPATNIILEPTVAQNYHHRVSCPIYTIPPASKSSPFPFTQSTYPRTPHHYLHPPRRVPVPKPADIQKQAHPATHSVLTPQTNPYHQKTDALITLGGDGTILHAASLFSSSRAVPPILSFAMGTLGFLGEFKWSEHQSAFKSLRSATDSCIRILRRNRLKAGVFGKNGERIGGEWGEYEGIEDAHAMNELSLHRGRDPHLTILEIFIGGHFLTEAVADGIIVSTPTGSTAYSLSSGGSIIHPSVPSLSLTPICPRSLSFRPLVLPEDAKITLRLSEKNRGREVEVSVDGRRWGGLGPGQEVRVWLEEINGDKGGIPCVKRLSAPEAEDGWVGGLNGLLKFNHPFGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBQ6</accession>
    <name>U4LBQ6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Probable hydrolase nit2 acc. no. O94660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_02831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBQ6"/>
    <dbReference type="STRING" id="1076935.U4LBQ6"/>
    <dbReference type="eggNOG" id="KOG0807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRVAVCQ"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX16235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="275" mass="29251" checksum="3051AE2CA68310E1" modified="2013-12-11" version="1">MALIACGQFSATNDVLANLKICRSLAARAAAAGAKALFLPEASDYISSSPAEGLTLLPQSTTLFLPGLCLAASTHSLSIIAGIHAPSSSPDLVRNTLVYISTTGLVSHSYNKLHLFDITLPSLTLRESASTEAGSSITPPIATPFGRLGLQICFDLRFPETARALVNQGAEILAYPSAFTVPTGRAHWEVLLRARAVEGQCYVVAAAQGGRHNEKRVSWGGAMVVSPWGEVLGRCKEGEEAGEPEICLAEVDLGLVHRVRVECPLRRRTDVYAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBU5</accession>
    <name>U4LBU5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936373">
        <property type="protein sequence ID" value="CCX16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBU5"/>
    <dbReference type="OrthoDB" id="10371574at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="236" mass="27072" checksum="A660ACF245A3DE77" modified="2013-12-11" version="1">MADKDSPARKKRAAKKATASKKNSARKSIAKKSVTKNPAANKTAIYNWSVDVAISTTKEEPTQQQPAQQEPTQQELNTDDHPKPVRVLSPFPPGLAESSETLSMRVQERRERYLATPQINYPPDFETEEEFHAWMLRGNHKLGFYFWSSIKSCTKHGHWIERDESIPEVPEGSSLPATYLRRVLGGWYLELHALEGEVLQALRNGEKLCCKGHEYLVDRLKKLEAGELRMERDHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBZ0</accession>
    <name>U4LBZ0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Glucan 1,3-beta-glucosidase acc. no. P49426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_05690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBZ0"/>
    <dbReference type="STRING" id="1076935.U4LBZ0"/>
    <dbReference type="eggNOG" id="ENOG502QV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AVFMNWN"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651228" evidence="1">
        <location>
            <begin position="22"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="440"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX29619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="810" mass="87534" checksum="7B513E4D8FAA2DCA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC13</accession>
    <name>U4LC13_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936378">
        <property type="protein sequence ID" value="CCX16335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LC13"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX16335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8100" checksum="9B46483E61754614" modified="2013-12-11" version="1">MCNAQYVLCTSSTARARKHGAFQSNVMKAQDYDCAKMSYRCAQTTRKAHKASISSSINCLWGVDQVMEYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4LC80</accession>
    <name>U4LC80_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="16">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PCON_11622</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 100304</strain>
            <tissue evidence="22">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="16"/>
    <dbReference type="EMBL" id="HF935675">
        <property type="protein sequence ID" value="CCX12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4LC80"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1664" mass="189985" checksum="B73AC5AA607603B2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCI1</accession>
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        <name evidence="1" type="ORF">PCON_11722</name>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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            <taxon>Pezizomycetes</taxon>
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        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="2">CBS 100304</strain>
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        <source>
            <dbReference type="EMBL" id="CCX12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="42" mass="4553" checksum="423C94645A1B6B1A" modified="2013-12-11" version="1">MRDIFPRLIQVHSSLLGEITVCASGGNAGQCIRVVEVLSRLN</sequence>
</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
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            <strain evidence="8">CBS 100304</strain>
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            <name>heme</name>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX17457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="20876" checksum="65184003CE10A830" modified="2013-12-11" version="1">MERKIKEFKAGEKPRDLASVLLADEKCGYGKLSMAAIYEDGRLIIGAGSETATGALTGALFYLHTYPRVLAKLRTILDATFTNGDEDYVYSFTHQIPYIDDIITELFRIQSPVADGLPRLTPKEGLVIDDIFIPGDVVVHVPIWVIQRQEMYYKKTEEFIPERWSDQPELVKDKRAYMPFGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEI6</accession>
    <name>U4LEI6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Probable serine hydrolase C5E4.05c acc. no. O94305</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_08743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935442">
        <property type="protein sequence ID" value="CCX30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEI6"/>
    <dbReference type="STRING" id="1076935.U4LEI6"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SYEGWSH"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="37"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="313" mass="34863" checksum="58218CFACB5D4CEE" modified="2013-12-11" version="1">MATPQADSFAMVTETEAQVSLTDGLSVYTKTWSPASPPVAQIFFLHGFSDHCNAYYDLPKTIAKSGIEFFSFDQRGWGRSALDKTQWGVSGSTEQLFSDLDELLRLRLEAHPSIPLFLVGHSMGGGIALSYAYSGSLRSKLAGIAVWAPLIDLAPNAKPPGFVVTAGKFASKFVPNWKRPQKMDAESMSRDEAVCRDYAEDPLCHGTGTLLGIVEMLVRAKKLMREDVVRRFLPETPILVCHGTADRVTDCQASRRFVEMLGVRDKEFREYKGWYHKMHAEPGEDREIFVKDIVDWTLKRTNQAKPSGGVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEN1</accession>
    <name>U4LEN1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_07940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935409">
        <property type="protein sequence ID" value="CCX30012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEN1"/>
    <dbReference type="eggNOG" id="ENOG502SFS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKDICET"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17615">
        <property type="entry name" value="C166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651387" evidence="1">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="214" mass="23196" checksum="5AA1584B17C5B60F" modified="2013-12-11" version="1">MQFFNYLTSFLLLGAVSASAIPVAEPVANAIAEPYTEAFPEPIAFPEESLDLPQVESSVTKTAVVMFTEKITKLSFDLRVTVEGTTPFNVLIRAPSIVLSFRNIVRDIILVIPDLAGNPFNAADAKDIVVVLTKFVEVHQQLLNVVIGKRGVLASFGGGFLEPVRLVLVTLEAIVDSFAFSLIKLIPTESVAANGQFAKLKVTVRKTITVYTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LEY5</accession>
    <name>U4LEY5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to UNC93-like protein C922.05c acc. no. Q9URX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_08617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LEY5"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCAGCLW"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX30418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="417" mass="47085" checksum="E1508B2AC124B049" modified="2013-12-11" version="1">MEEPNFTEMGGAGQLDSTVASRANTALYSTFSIVGFCAGTFLNYCIYSASFYSYNHTKNQGFVTFSGALLGVCAAFLWCAQGTVMMAYPSENKKGRYIGIFWAIFNLGAVIGSCIPMANQWHTQKTVNVNDGTYIGFMVLMAFGGILAWFLVPPEKIVRKDGSRVQQIRHPSAISELKGLYQTLILDPWIILLFPFFFASNYFYTYQLSSYNLYMFNTRTRSFTGLFYWLSQILGSLSFGWFLDISFLTRRSRAILGWLFLFLIVNSVWGGGLSAELLLHRPPSGTSEQNFAKFNPVIDIYETERGFVGYFWLFVFYGFMDACWQTYAYWLMGAMSNDPRRLAYFAGFYKGIQSAGGAVAWGIDMGKIEIRGLYISSWALCGAGLLCAVPVVWKRVRDTEMEEEEKEEQGELAEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4LF73</accession>
    <name>U4LF73_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935428">
        <property type="protein sequence ID" value="CCX30192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LF73"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="255" mass="28023" checksum="D1A083077F69A8E1" modified="2013-12-11" version="1">MHVDLAHQILRPLASFNLEPATKVGALKEVLADISFGKDSSVKPEDITLTHEGRELDDDSILGQQLIEDDSTVTVYIKDAAKQLELLKNANRLANTHVDYRLEIKVLKNTVDDLHKKYLGVLKQLEAASKELVHLHSLRRQARVGNTMETTGSACVTEPPQSQFTDKQGLKDTTGPHYTVVPARFTDKRGLNDNTAPSGIVMSPELSDKRGQQGTAGLDPAVASAQLTELTNKRGRKAVRKQQLKSEETNLGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4LFB6</accession>
    <name>U4LFB6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to 40S ribosomal protein S20 acc. no. P23403</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935887">
        <property type="protein sequence ID" value="CCX13674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LFB6"/>
    <dbReference type="STRING" id="1076935.U4LFB6"/>
    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAYPMKP"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="117" mass="13266" checksum="3A020AC9D2CFDCDE" modified="2013-12-11" version="1">MSYNKPGKDEFGEGPKMHRIRITLSSRHVQALEKVTTELLERAKSKNLRVKGPVRLPTKTLKITTRKTPCGEGSKTWDMYEMRIHKRLIDLNAPTEIVKQIIVNIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4LG21</accession>
    <name>U4LG21_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to DNA damage response protein wss1 acc. no. Q9P7B5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_08691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935441">
        <property type="protein sequence ID" value="CCX30492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LG21"/>
    <dbReference type="STRING" id="1076935.U4LG21"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VLPEHLC"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07344">
        <property type="entry name" value="M48_yhfN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX30492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="476" mass="52829" checksum="AA7D5FBC8C135789" modified="2013-12-11" version="1">MPLGIERINARRRSPNALINFITPLEGADKAIAQDYLERIAAIVYPIMKENNLAVMTLDEFPPNKEFWGRNFNAGEVIQLVLKHPSTSQWLPFKFVQGVMIHELAHIKQMNHSSSFWAVRNRYARELDVLHARGYTGEGFWSAGRSLLSEQYTQDRPLAESEMPKQICGGTYRSRNRRRRTQPAEKLSSSEQKKRRIERKMSPYGPARALTTEDSPANDGKSKPRVAQSKRGRELRVAAALKRFEQKKEEETIVDPKIEGEEASSSDEEEKVVNVGGGKFLVPVSAKEGTTCDSEDNQHRELLELLGGEVCGSSRQHVAPAGRDRQEDTNNTVKATPKIGGQSSRSSPSQTTALTLGKKMQKRELPPTVLPSNRTANPHTATHSLKPSRSSPGNNDPPTPIPTSSTISVIDLSETELCPICSFENLENTPTCAACMNVLVPSDSAWKCSNISACHSEYRNSRDVVFCGICGSRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGC1</accession>
    <name>U4LGC1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to UPF0695 membrane protein YOR390W acc. no. Q08913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_10113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935546">
        <property type="protein sequence ID" value="CCX31159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGC1"/>
    <dbReference type="STRING" id="1076935.U4LGC1"/>
    <dbReference type="eggNOG" id="ENOG502QT5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KANTYKR"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX31159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="493" mass="51835" checksum="1C18E65924BE5EF9" modified="2013-12-11" version="1">MPDDNDVELHPRPPAAAIAIPNAGFENNNNNALAMPATPAAPTNESSGALRPPTVSPSASTSTVSSLNSPAIEAAIAAEKARNAEKPRDESDLDALSRSLKPLRTVTDLEKGTDLDGDGEGLDHIASELSPRNDGEDHPPNLENLPLPVYPERHPSTSTRSSSSTGSIPSRLTERSHRPSTLGTFLRLHAHLILFSILGTLARLGINALTTYPTSPLGGTVIWSNFTGCLIMGALVSDASLGIFGSRSRAAYIGFTTGFCGSFTSFSSYELDGMNLLLIGGAGERIMAWLGYTAATFAISLAGLQLGAHFASAAATIVKDWNFETKQKASSRIQTWAKRIEFVLLPLTAGVWAGAVVLTVIEVSYRGPASLACVFAPMGAMVRFWVSRGLNKKKKSFPLGTFGCNFVATMILAGTTIGRARHGGSGCQVLKGVGDGFCGTLSTVSTFVVELRGLKTRAAYLYAAGSVMAGTVVMVAMVGGFTWGTTGELRMMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGI8</accession>
    <name>U4LGI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Putative vacuolar protein sorting-associated protein TDA6 acc. no. Q06466</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935464">
        <property type="protein sequence ID" value="CCX30647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGI8"/>
    <dbReference type="STRING" id="1076935.U4LGI8"/>
    <dbReference type="eggNOG" id="ENOG502RJPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LFGQAKF"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX30647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="435" mass="48924" checksum="2E0EA40E5FCD5A05" modified="2013-12-11" version="1">MSSSPPPKRQLTTKLLAVALSATLLATLTLIFTTASAGTCSHPDGPSPLGDRICWRLSPCRNQKPTSNPIRKLWKPRGNSTTPIQKAPEFVLKYAPYVYLHSEERFHPGDIAEHLIHTTPHLNLTPLDSSSAPSPLLLSNLEKLNSLGPEDVYLTSNDDPAYPPPWLRGNRNIPDHYGKSRAPAIIIWAEKSPGVIDAFYFYFYSFNLGNTVAGWRFGNHVGDWEHTAIRFVDGKPIGMFFSEHSSGKAYQFSVVEKIGNRPVTYSASGSHANYATPGTHYYAIPFHLLFDRTDKGYLWDPAQNNYLYHYDIKKDELSPDQKNPNAPVSWFHFEGKWGDMIYPLNDKRQYRVVGQYHYVNGPTGPKSKNLDRLEVCQNAGVCILLPSLRDTSHSGLVRQGQSVAPQKPQSVERKVKVEFGTRETKMREAVKDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LGP3</accession>
    <name>U4LGP3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935466">
        <property type="protein sequence ID" value="CCX30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LGP3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="65" mass="7094" checksum="B811A343361B5448" modified="2013-12-11" version="1">MCNHHQIYRSATTATTATTRPPDTLPSCRHRTGFPTRVVLTPSMPVSGPRGGRPETRGIPRPSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHH4</accession>
    <name>U4LHH4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Transcription initiation factor TFIID subunit 9 acc. no. Q05027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_10669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935589">
        <property type="protein sequence ID" value="CCX31368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHH4"/>
    <dbReference type="STRING" id="1076935.U4LHH4"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNMKDEW"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX31368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="221" mass="23558" checksum="A12E38CC3A20BF56" modified="2013-12-11" version="1">MATPAAGAGASSSPPAADSAATITSASVDKPAPSTGDSSSRKPRDARLIHLVLSSMNVTAYQERVPLMLMDFAYRYTSGVLQDALLFSDAINGTANTGGQNPPATIGPDDLRMSIASRVNHQFNTSLPKEFLLDISQERNRVALPTVGPEFGVRLPPEKYCLTGVNWDLKEAGGEEMDTDDEEETQMGMGPITGLGGREQEDEDQMEVEDLFGEDTSMGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LHL6</accession>
    <name>U4LHL6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PCON_10760</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 100304</strain>
            <tissue evidence="15">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HF935596">
        <property type="protein sequence ID" value="CCX31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LHL6"/>
    <dbReference type="STRING" id="1076935.U4LHL6"/>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TSAYGMY"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCX31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="424" mass="45914" checksum="9E108C963AB07FE0" modified="2013-12-11" version="1">MANRFLATQEGSGIEVVKGQNDSPTAEAVLPPHRRRQQNKARASADSSELPPDASSLLSTSSAASSSSLRREALAYLSLSKPRLTALIVLTTMASYALYPVDPLLSSSAAPTLSALTLVYLTVGTTLCSSSANALNMAYEPKFDAQMSRTKNRPLVRGLLSTTQAVGFASLTGSVGVAALYLGVNPTVAALGALNIFLYAGVYTPMKRLSVANTWVGAIVGGIPPLMGWAAASGATALDGTMMELLGHPGGWLLASLLFAWQFPHFNALSWTIREEYKQAGYQMMAWKYPKMNARVSLRYSLLFFPICYGLWFYGVTDVGFLVDSSVVNAWLVREAWKFYREGGEGGRARGLFWASVWHLPLLLGLAMAHKAGMWQGFYERIMGIGREDVDEEWEEEEESSNKEGKILPAVAAMESARAAQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LIS9</accession>
    <name>U4LIS9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935685">
        <property type="protein sequence ID" value="CCX12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LIS9"/>
    <dbReference type="OrthoDB" id="10325301at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13602" checksum="E805C2F7A7129866" modified="2013-12-11" version="1">MSTQQNQSFRPEAPKRRDTTTRRDPHTGDLIQEYSGNDSGPAMRTHYDWDAAAKEEAQKQAQKGQQQKPAPVKRSNTTISHNAAGDRIEEHDGEGSLAIRAIYNSDDEDTSRGGLYRGSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ83</accession>
    <name>U4LJ83_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ83"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="118" mass="12841" checksum="F979F77AC3434A43" modified="2013-12-11" version="1">MPRALFTAMPNETYVRFPHGLRRCQREPAVASGTLNRAGLAVRQVPHGGNDYLRPGALQATGLSLSPRSTGGRQRVVKCVQRSLSSCLDQEEQVNTSISTRGFSHASCWIKARCSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LJ94</accession>
    <name>U4LJ94_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_11099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935622">
        <property type="protein sequence ID" value="CCX31632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LJ94"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="4139" checksum="A071DE4E2B6CBA42" modified="2013-12-11" version="1">MPGVDFDSVDGHCSHGSKAGAVHAWQGLKLGYFYATTVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LK77</accession>
    <name>U4LK77_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein R707 acc. no. Q5UNW1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_12689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935778">
        <property type="protein sequence ID" value="CCX13096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LK77"/>
    <dbReference type="STRING" id="1076935.U4LK77"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HVCVCNL"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX13096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="334" mass="38180" checksum="9B8DD7E476E936A1" modified="2013-12-11" version="1">MSTASSLPPGPPYSLPSSPLDSSNDDDKKPGAWIVLLTQASYLPGVIILGYSLRKVKSKYPLVAAVTPSLPEDCREALIDCGIKIKEIAPLKPKDEVTVVAERFEDTWSKLAVFGFEGYKRAVLIDADMLVLKNMDHLMDLPLPKDWIAANHACVCNLDRDSWAPEDWREENCAYTPMVHPDALENPTQVTPSSIRTHTLLNSGLVVFTPSKVVLDQMLDFLATSPLVQDFSFPDQDFLAHFYKDKWMPIGWQYNAIKTARYWHPKMWNDDAVVNVHYICDKPWNVGKKRGTDDEVTHKWWWDHFDEWRNLMVGYKERRSVNIVEKYASDEHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKI4</accession>
    <name>U4LKI4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Putative transporter C543.05c acc. no. Q9HGM6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF935851">
        <property type="protein sequence ID" value="CCX32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKI4"/>
    <dbReference type="STRING" id="1076935.U4LKI4"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SLMHTEK"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="61"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="327"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="578" mass="64549" checksum="2924448D370B6198" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4LKQ1</accession>
    <name>U4LKQ1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_13358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LKQ1"/>
    <dbReference type="STRING" id="1076935.U4LKQ1"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX32518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="88" mass="9796" checksum="28818C8DA8456C98" modified="2013-12-11" version="1">MENEKGEIVDLYVPRKCSATNRIIKAKDHASVQISVGKVDENGRYTGESINYALCGFVRSMGEGDDSLNRLAQRDGLLKNVWTAARQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>U4LL25</accession>
    <name>U4LL25_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LL25"/>
    <dbReference type="STRING" id="1076935.U4LL25"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="7">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="6">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX32784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="161" mass="18597" checksum="673356182D90A6DF" modified="2013-12-11" version="1">MAVQIKLMSSDQAMLVVDKEVAERSVLIKNMLDDIGEVDEAIPIPNVNEAVLKKVIEWCEHHKGDSPSTNDEESDSRKRSTDIEEWDQKFMQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKSPEEIRKTFNIQNDFTAEEEEQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LLF2</accession>
    <name>U4LLF2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935909">
        <property type="protein sequence ID" value="CCX14180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LLF2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX14180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="97" mass="10798" checksum="458EC4DFD922C0EC" modified="2013-12-11" version="1">MEGRTASLWPTESSCPRQVEASTSMHQHPSLPPAPTTKARKEPSQEPSQEPSQEPSQNHLPPIMLRDQDAVSSSRGHSSQLRHALLYHRMPLFPAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM40</accession>
    <name>U4LM40_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_13508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM40"/>
    <dbReference type="eggNOG" id="ENOG502SG05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5278621at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX32657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="129" mass="13674" checksum="377CADE7BFA0FC9C" modified="2013-12-11" version="1">MAGVFDKNKNLCDSKRPGELGFEYGTSEMLTAQDLTDGVYEDPHDLRHMASDYPSNRGSSMLKDHHGGHNPAKAFTSKGAVGKEFNADGAIGQVPQKIGGAFDKNGSIGKQFTDKGAIGGTTDKVLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4LM49</accession>
    <name>U4LM49_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PCON_13518</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 100304</strain>
            <tissue evidence="19">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5"/>
    <dbReference type="EMBL" id="HF935906">
        <property type="protein sequence ID" value="CCX32667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LM49"/>
    <dbReference type="STRING" id="1076935.U4LM49"/>
    <dbReference type="eggNOG" id="KOG2794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="15">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="15">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCX32667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="340" mass="36818" checksum="03B2ADDE3463E7EE" modified="2013-12-11" version="1">MSESQVSSILQGGYHHPLSRQWQAERQLTKAPNSPQSALVYPLFITDNPDEESLVASLPGQYRRGVNKIVPFLEPLVKLGLRSVILFGVPLAPTAKDPTGSQASAQDGPVVQGIKIIKKAFPQMFVMADVCLCEYTSHGHCGILNEDGTLHQELSCQRMAEISVDYARAGADAVAPSDMNDGRILAIKTGLMKAGIAHKTMLISYAAKFSGSLYGPFRDAAGSAPSFGDRKCYQLPPSARGLARRAIQRDLREGADGIMVKPAGWFLDIVSDAKEIAKDVPISCYQVSGEFAMIHAAAEKGVFDLKQAALESLEGMMRAGANTILTYFCEQILKEGWLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMH0</accession>
    <name>U4LMH0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_14349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936042">
        <property type="protein sequence ID" value="CCX33309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMH0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX33309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="159" mass="18964" checksum="6D7EB869C36AB022" modified="2013-12-11" version="1">MPSQQPQPPRTPRRSKRHQRIILNRHLCYDTAPRIKAQRIERNMFRRPDMSPSKHDLTTTKLGYEGHCKRKSIFSRNCGKTKGYHKNDNREENSGEYFTSNFGLAVKRWKRHNGWKADPEAKRVWEELDGKQIRFWGIPKEREEDVFLVGERIMEDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMP7</accession>
    <name>U4LMP7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cytochrome c oxidase assembly protein COX19 acc. no. Q462Q7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PCON_13693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 100304</strain>
            <tissue evidence="7">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935907">
        <property type="protein sequence ID" value="CCX32842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMP7"/>
    <dbReference type="STRING" id="1076935.U4LMP7"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHECDSE"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCX32842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="133" mass="14819" checksum="FBDB30A3205779A4" modified="2013-12-11" version="1">MSGFGRPPGALTFSPTPPQRGAFPLDHDGECKPIMTEYLACLKRVKGTNDMACRLIAKEYLKCRMERQLMAEDSFENLGFQDEKKAAPVSPVTEARSEAAAAASSSASNRLEELKRENARLVEERKKQEAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LMY3</accession>
    <name>U4LMY3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to DUF636 domain protein [Aspergillus fumigatus A1163] acc. no. EDP49724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_01341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936132">
        <property type="protein sequence ID" value="CCX33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LMY3"/>
    <dbReference type="STRING" id="1076935.U4LMY3"/>
    <dbReference type="eggNOG" id="ENOG502SAKJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCGCTLW"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="149" mass="16260" checksum="26CD90ACDA42162D" modified="2013-12-11" version="1">MSEPTPTPITGTCLCRSLKLIIPSGITPIKTLLCHCVDCQKNSGAPFQSNAMFNTSDLIIEDPQGLLKTYKIEEGTASGKPKEKGWCGKCGCPLYTKPGHYEGRMMVVKTGFLDGGADHFPPQIEIFTADRAKFLAPAEGVKQFERMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP28</accession>
    <name>U4LP28_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_09918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935534">
        <property type="protein sequence ID" value="CCX31090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP28"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX31090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13656" checksum="C41BE2A618260D31" modified="2013-12-11" version="1">MSQEDSTPTFNICAGKAKIKACTFDYAGKRAEINAVWETFKDRYPDEEGSVEILIGMSNVEDTCCRRLPNTTGLRGSRTKGLNRLVTNLLQIVYNVVAHPDDVAKLMKMIEDVIKDLNNISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LP45</accession>
    <name>U4LP45_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroorotase</fullName>
            <ecNumber evidence="4">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_02184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="4"/>
    <dbReference type="EMBL" id="HF936260">
        <property type="protein sequence ID" value="CCX33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LP45"/>
    <dbReference type="STRING" id="1076935.U4LP45"/>
    <dbReference type="eggNOG" id="KOG2902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000041">
        <property type="entry name" value="Dihydroorotase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="60"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="352" mass="37773" checksum="0FF2FB20F49B0757" modified="2013-12-11" version="1">MASITLPAAADFHVHLRDGSMMETVVPTVRQGGASLAYVMPNLVPAITTVEQALEYHSKLQALDPSVAFLMTLYLSPEITPDVIRAAAATGKIAGVKSYPKGLTTNSEGGVVDYAAFYPVFAAMEECDMVLNIHGESPSSETTTILNAEETFLPTLKALHERFPNLRIVLEHCTTAAAVEAVKACGANVAATITAHHLYLTIDQWADNPHCFCKPVAKLPSDRAALLEAATSGNPKFFLGTDSAPHPRSAKVGTANGKTAAGVFTQPYAVQYVASAFDRMGKLDKLRAFVCDFGRDFYKTVEKGWETAEDITKDAIVLEKEPGQVVVAEIGQGEGAVVPFMAGEKLWGVRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQA1</accession>
    <name>U4LQA1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_02635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF936305">
        <property type="protein sequence ID" value="CCX34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQA1"/>
    <dbReference type="eggNOG" id="ENOG502QQR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QCHISRY"/>
    <dbReference type="OrthoDB" id="78198at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48471">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48471:SF1">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="235" mass="26511" checksum="54134B92CAEBAF9C" modified="2013-12-11" version="1">MADFSLQQIFGLTPAVCFRYRKLGMILLLRCLKGMAKARLRWPKRSGMCRYSRPIRARHPLLTKAFGFVDGLYLPIARSSDLDMENAYYNGWCSSHYTSNILAFGPDGTIFHATMNAPGSWHDVAVSQFLYRHLLEDTPSNYYLAADTAFATSNQEIRDKLRTPPKAGFTGFSPNPTIALQQVAYNDQLVSARQAAEWRVGILQGSFSRLKLPMPAENAEYRQLLLETCVTLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQN0</accession>
    <name>U4LQN0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PCON_05682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 100304</strain>
            <tissue evidence="13">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQN0"/>
    <dbReference type="STRING" id="1076935.U4LQN0"/>
    <dbReference type="eggNOG" id="KOG4655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCX29611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="184" mass="21617" checksum="9EE7EBD125E6F9E2" modified="2013-12-11" version="1">MVRALKHHEKKLLKKVDFLEWKSDSAHRDHDIMRRYHIQDPQTYHKYNKICGSIRHLAHRLALLNPTDPFRRKHEELLLAKLHSMGLLAQKTKMSDVENKITVAALCRRRLPIIMTRLRMAENVPAAVKLIEQGHVRVGPEVVTDPAYLVTRNMEDFVTWVEGSKIKQHIMKYRNEVDDFDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4LQU7</accession>
    <name>U4LQU7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935629">
        <property type="protein sequence ID" value="CCX31710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LQU7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX31710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="107" mass="11859" checksum="47C77BBB95A875A7" modified="2013-12-11" version="1">MPVSGVVPGCTDLCSVRNETKFRCRRSHRPRAALSRSPAPARLVARGSTPGAVWGSGAKENLSRRSLKSSQVTQNDTTNFRMVLVQAWTRYICRVSLPGYSRTPWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRL3</accession>
    <name>U4LRL3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936631">
        <property type="protein sequence ID" value="CCX34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRL3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="121" mass="13741" checksum="398BF642A16D0E23" modified="2013-12-11" version="1">MASCPRSPNHSNTNTTPPPACPYPSNQPSAHDVIEYQRIRVATIENSFRRVQAFIRIIVTTAIGYAIFSYAGLYFVGCWAVCWFIILAGWRDLGTLLLSKCPTHHMHRVLPGRKVRCINYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4LRT8</accession>
    <name>U4LRT8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936663">
        <property type="protein sequence ID" value="CCX34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LRT8"/>
    <dbReference type="STRING" id="1076935.U4LRT8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="282" mass="31578" checksum="10FE919093EEE750" modified="2013-12-11" version="1">MADTINKDIEADPASAQTDAEEYSSGYVTDTASLTSSINSYVFENGRRYHTYFGTEKNLQPADETEQDRLDLHHESFLILLSKRLHFAPISAPMSILDVTDAYPCASSLGIDLSPIQPHWIPPNCRFEVDDAEADWSYADGSFDLIHICNIAQGIKDYPKLLEQSFRCTQPKRYLCLAELELSINSDDGTHMLPQGEGINKMSKLLADALEKIGRPRLVTAEMLKHGLEKAGYQEMKVETYKQPLGPWAKNKDLKAVGATNLLSGETVTMHMEWLCSPAFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4LS89</accession>
    <name>U4LS89_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Probable RNA-binding protein sce3 acc. no. O14369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PCON_03718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 100304</strain>
            <tissue evidence="5">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936538">
        <property type="protein sequence ID" value="CCX34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LS89"/>
    <dbReference type="STRING" id="1076935.U4LS89"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVENWAD"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCX34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="438" mass="47798" checksum="D73E935FF480E264" modified="2013-12-11" version="1">MAPKKKVTMGLGEFLADETYGTAAGGSWADEMEDFPPMLNLGAGTSSGYGARRNDYGSASNNTSSAPSGGNDRLQGYSRVDDGERFARTTLPIPDKPPYTTHIGNLDFSVSEEEIKGFFANCDVLNVRLVRDREQDRPKGFGYVEFNSREGLVAALDLTGQNLAGRPVRISVAEPPKERVESRSFGPWRSGGPPPTLKEEHTRTVKQEEHTRIHDGPWQRNGRLPAPAPSADGGNRPERRIPNVGDGRTSWRSERAAVPAAPTSPTPTGPPKLALAPRTLPVNAEAATTSSSSVFGSATPVNTADYAEEVMRKRREQKKAEAEKAEAERKKREEEAAAAQAAAAEKAKNEPLKVEPKVGGRNPQRREFASPKGSDAPQTKYSKEWRRGPDEPEKTELKQAESEKTELKQAEPEKGTDSWSTVTNNKGRQRRQNKTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LTR9</accession>
    <name>U4LTR9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Deoxyribonuclease Tat-D acc. no. Q9UUF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_14091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936006">
        <property type="protein sequence ID" value="CCX33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LTR9"/>
    <dbReference type="STRING" id="1076935.U4LTR9"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="400" mass="44468" checksum="FBB3EB6CAA1EAA08" modified="2013-12-11" version="1">MHLPTAFLRVALRRTVLPSSKPSFINFPIRHLSSTTHKMSTIPTPPITPLTPFTPLTPSSIHSNDTDATSVADETESQDGNEEYTPRYIDVGINLTDPMFSGIYHGKQYHESDLEDVISRAKESGCKKLLVTGSDLIESGEALKMATEHPGFIFATVGVHPCSSSQFESPTHLPEDGEEYLQKLKELAMSSPQVGAFGEIGLDYDRLSYADKETQNKWFSRQLDIAVEVGLPLFLHSRAAADDFEKELLKMPRWEKLKGGLVHSFTGTKEEMWKLVNAGLYIGINGCSLKTEENLEVVKEVPLESLMLETDGPWCEIKRTHASAKYLEEAPPIAPTVKNKKWKKGCLVKDRNEPALISNVATVIAKVKGVTTKEVIEAAWENTVKLFSRLDDAPAEKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LU96</accession>
    <name>U4LU96_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_10815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935600">
        <property type="protein sequence ID" value="CCX31466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LU96"/>
    <dbReference type="STRING" id="1076935.U4LU96"/>
    <dbReference type="OMA" id="HWKDHEG"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651676" evidence="2">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX31466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="251" mass="29056" checksum="F0CB90FB4DF0CE5F" modified="2013-12-11" version="1">MRFTLATVSVALLGLAMAAPAAEAAPEAAAVAAPAGGHRSGHCSSYDCKKDDDHHGGKKNWDHDHKASHKHKGKHDDDDHHNKGWGKHSGHHYKREAAQGYGDDHGKHDDHDRHGKKHDDHDKHDDHDKHDDHDKHDDHDKHDDHDKHDNKGWGKYSGRSYKREAAPGYGDDHRKHDNDRHGNKKYGTKKAGHGDHDDHKKWDKHHGHDNKKWDKHDGHDNKKWDKHHGHDNKWDKHHDHDNKKWDKHHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVE5</accession>
    <name>U4LVE5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_03766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936539">
        <property type="protein sequence ID" value="CCX34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LVE5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="147" mass="17055" checksum="FFEA5FBCE9AB7649" modified="2013-12-11" version="1">MDVQRELMRVKVTQKEYLFIREQLRKTEEKRLLLVREIRYLKNGHAALKKEATSLRSDRTQLNNYFRAAEEQARILEEQNKELTNLVKVQSEKAKIVVDILAGCGFAENKDSKENYQLVKEALNSIIMKGDTADVLEGSGHEKMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4LVI8</accession>
    <name>U4LVI8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Striatin Pro11 acc. no. Q70M86</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_13421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935890">
        <property type="protein sequence ID" value="CCX32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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            <authorList>
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX34702.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCX33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="16" mass="1981" checksum="1129607B77798686" modified="2013-12-11" version="1">MVPRALQFPNQSLYWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LWF7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <location>
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            <end position="78"/>
        </location>
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        <location>
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            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22529" checksum="8A508A4698A4DF35" modified="2013-12-11" version="1">MEDGHAFAEEIEEEEDEVTVMIRTLSHLNPRASKSADRLPFVVSPLIAVLYRFESFLRFFFNPFISFLCSNEIVWVWIWRSMARRSLNTPTGVSSSLQHWKRQRYSIPSLRVSGPRTEGGRAMRRIRPHLNLGNLAAAADDEEPFEQAFDDMKHQAVAAQASVPGVRPSFTASPAALLTTPPSSTRNQRPPPPPPSSKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LYM1</accession>
    <name>U4LYM1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_04634</name>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936670">
        <property type="protein sequence ID" value="CCX34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LYM1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="20" mass="2307" checksum="3B7C4E9EA896CBE4" modified="2013-12-11" version="1">MEMECLLMSGSTDFHFLPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KTU0</accession>
    <name>U4KTU0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_02016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935202">
        <property type="protein sequence ID" value="CCX04413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KTU0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX04413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="136" mass="15628" checksum="CB9765ECBB7EFF3E" modified="2013-12-11" version="1">MTCMLMFPVLCIYPSSSHDKSANTRNRQWQKFRTQKRLKNRLFGSIQCHHLSFAVSRFRATKHSIWGGKKGTTRRQFLAIRSWPSSSKSVEIRRLPFQPDTRPLPTTSAKFNKPFRAALSLAIPQNDGLITLIPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUE6</accession>
    <name>U4KUE6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_01894</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="HF935199">
        <property type="protein sequence ID" value="CCX04346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUE6"/>
    <dbReference type="STRING" id="1076935.U4KUE6"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="73"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX04346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="378" mass="41302" checksum="0550233895D46C8B" modified="2013-12-11" version="1">MFRPTRALLSAARAYSTVLPGTPRVAGALQNAMNQTAPRTNWTKEEITEIYETPLMELTFAAASIHRRFHNPADLQLCTLHNIKTGGCSEDCSYCSQSSRHNTGLKATPLVSVDTVLSAARVAKDNGSTRFCLGAAWRDMRGRKSGLKNIKAMVEGVRAMDMEVCVTLGMIDAAQAKELKDAGLTAYNHNVDTSREFYPSVITTRSYDERLDTIKNVREAGINVCSGGILGLGETKEDHVGMIYTLGTMPSHPESVPINALVPIKGTPLEGNKPLPFVDILRTVATARCVMPASIVRLAAGRITLKEEQQAMCFMAGANAVFTGERMLTTDCSGWDEDKGMMERWGLVPMKSFQRGGYRAKMEAEKETAAEQITKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUG0</accession>
    <name>U4KUG0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935213">
        <property type="protein sequence ID" value="CCX04667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUG0"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="298" mass="33816" checksum="C42E1D66009BD1DB" modified="2013-12-11" version="1">MAYLTFSIFPNRLTKPVISRFIPTRTPYRTTSPRSAMVKQYRETTGLARNIGFFSTPKLAAGTCCNQRFGQQRSKSHNTKQQAMGGTLFFPPNRIQQIRYSTQRRSYARLNNFLKVPFGPFRPPGPPKAPKIPRNSKAPKILKTPRDALFRIYKTTTTKSGKSNYRTFVSQETFQVDIDSKGIHRLHGHYFSEECGGYQKIASIMIERMSLNFKEVMKNGFVLGMGVIKYVMLLGITLVYFRNWVVGWVYGVADGFATKVEAIWEEILGRRPGWARGLVYCVCGGGCYGLGCVLSDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4KUX2</accession>
    <name>U4KUX2_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_04825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935239">
        <property type="protein sequence ID" value="CCX05238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KUX2"/>
    <dbReference type="STRING" id="1076935.U4KUX2"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX05238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="488" mass="52031" checksum="2D7BAB8669BF24F1" modified="2013-12-11" version="1">MAEEVHKHLCGPGPEIQRTGTPTVYGPYHVGGPATPAKTPTLRRMKSSANLAPDVPKGWATHWDEKEAAWYYTNTSTNLSQWTAPASPANLFATLPKSRSPARPPAPPRENTSSRLEKAYPKTNMTQVIKSSPGNTGRPGSSLRTEPIKRTLTPKPSKIPSAIPKPASKTTPPKSSPSPLKSVKRAPTIPPKPMAYMPAQPSRSKTPAPTTSPKSVRAAHSTPRPSISHAATVPATPRVVSNPKLAAPSNLGSPISLRPSAGLPKAPVRKVSPTISKNPPTPHLRPTVITNPRGPRLAASVISALASKPEKAYAMAFTISWPEAIDIPMTFLIDPSAEHMVVSRSFVRQYGIPTTLRQEPISITTKEGKKITGAGLEKTTRLVLRHKEHYSLEEFEVADLAMGDKCQGVLPGGYLEEHTLEGGFASVRCLQECNKVAVGGYLGGGLRVNGMLGMQGIKGGKSMVGGKSMVGGRVWWGEEYGGESVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV32</accession>
    <name>U4KV32_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
        <property type="protein sequence ID" value="CCX05022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV32"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="74" mass="8494" checksum="264E086E2C27FDBE" modified="2013-12-11" version="1">MNPFFIGALTAPGGYHFGSVFTQTTGSGTMPAYVCLIVFLAFPRIHKLHVNLHQEYNYHGWFFVMTSNQHRQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KV74</accession>
    <name>U4KV74_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_03667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="HF935217">
        <property type="protein sequence ID" value="CCX04776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KV74"/>
    <dbReference type="STRING" id="1076935.U4KV74"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX04776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18716" checksum="04B9F8B3D4205701" modified="2013-12-11" version="1">MASLFSETLLPTTTELPEGYSVRPLQRTDYQKGFLDVLRVLTKVGDISEEAWLERYDWMAKRNEEYFIICIVNGEGTIVGVGSLVIERKFLRNLGAVGHIEDITVQSSEQGKKLGLRIIQTLDHIAQQVGCYKCILDCSEKNQPFYEKCGYKLAGVQMVYHITTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>U4KVI0</accession>
    <name>U4KVI0_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_04889</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935244">
        <property type="protein sequence ID" value="CCX05302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KVI0"/>
    <dbReference type="STRING" id="1076935.U4KVI0"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="405"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCX05302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="766" mass="88173" checksum="3EF32CF3B492267E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4KW13</accession>
    <name>U4KW13_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935261">
        <property type="protein sequence ID" value="CCX05562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KW13"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="100" mass="11629" checksum="6C326DA3A26BE298" modified="2013-12-11" version="1">MSDDEARNMIRFPPKPSVVRKAVLPKPSAVRKAVSKVADLKQALKPEKQRTKTPEECQLELDQKEHEKAIKKMRRKHEKELKKARKKGQPRRSIIKVIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWB3</accession>
    <name>U4KWB3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Replication termination protein acc. no. P68733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935271">
        <property type="protein sequence ID" value="CCX05742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWB3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003432">
        <property type="entry name" value="RTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02334">
        <property type="entry name" value="RTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021424">
        <property type="entry name" value="RTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="134" mass="15909" checksum="BB485843BBB751C0" modified="2013-12-11" version="1">MNRKLQVKIRRRLGMGFMIAQRAYIKLYLITMVEQHRGYGYEMLVAMKQEFKPYGYVPPQSEIYRALHELVQQGVLYRTKKLKGNDPKVDFQEIVLYHFTNDGAEKAELYKKQVKTDLDRCLNMLHKAVNDNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWJ1</accession>
    <name>U4KWJ1_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_05844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935283">
        <property type="protein sequence ID" value="CCX06257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWJ1"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="39" mass="4615" checksum="B1C8EA4123EE00CA" modified="2013-12-11" version="1">MRKEALETDTTSEKPAMIAEGRRNEQFENSIENTDRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWS2</accession>
    <name>U4KWS2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Isovaleryl-CoA dehydrogenase, mitochondrial acc. no. Q5RBD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PCON_05258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 100304</strain>
            <tissue evidence="9">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWS2"/>
    <dbReference type="STRING" id="1076935.U4KWS2"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="166"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="274"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCX05671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="427" mass="46288" checksum="5DE08CA710F699A9" modified="2013-12-11" version="1">MSFLATFRPQRVLNTARRLRPTSYLKPGAFTAVRFATTKQTATFKPPTSEDLIELRERVQEFTRREIPEEFAAHVDKVNEFPAEMWKKLGSAGFLGITAEEEYGGLDMGYQAHCIVMEEISRASASIGLSYAAHSNLCINQLTLHATKEQKERFLPGLISGDLVGALAMSEHSAGSDVVSMKSNLKATETGGWVLNGTKMWITNGPDADVIIVYAKSDLQAGKKGITATLVEKGMKGFSVAQKLDKFGMRGSNTGELVFEDVEIPAGNQLGATGEGVKVLMSGLDLERLVLSAGPIGIMQACMDITLPYVHTRKQFDTPIGHFQLMQGKLADMHVKLSAARAYTMAAARAADEGAFDTRDCAGAIMYASNMAVECANDAMQALGGNGFINEYPAGRLLRDSRLYTVGAGSTEVRQIVIGRSFNKEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KWT5</accession>
    <name>U4KWT5_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935265">
        <property type="protein sequence ID" value="CCX05691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KWT5"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="41" mass="4784" checksum="7D68A9D6DF011A1A" modified="2013-12-11" version="1">MRCRTSRQLIYSSDLLQKQRHDIPWIFSSASVASDISYNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>U4KX63</accession>
    <name>U4KX63_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Hit family protein 1 acc. no. O94586</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_06184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935300">
        <property type="protein sequence ID" value="CCX06597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KX63"/>
    <dbReference type="STRING" id="1076935.U4KX63"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX06597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="187" mass="20753" checksum="AFBCD540A8ECCF1D" modified="2013-12-11" version="1">MSLAPPKPSTSSVSTPNPATVPSAKSPTTTLRSLPQIPIPTHHPHFPLTSPNPTSSYQPPKSHYEKLTDLPSSINASIGAWLPIIARAACAVSGYADFNVVQNNGINAAQVVPHVHYHIIPRPDERQREELEKKVPREFKKWWKSPFGSGWRVELDEEEAKEMVGKLRTEVGRLAELEKKREGKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXI3</accession>
    <name>U4KXI3_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935194">
        <property type="protein sequence ID" value="CCX04254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXI3"/>
    <dbReference type="STRING" id="1076935.U4KXI3"/>
    <dbReference type="eggNOG" id="ENOG502S54P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HAWNCTC"/>
    <dbReference type="OrthoDB" id="5413281at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24827" checksum="A5C5246E7F11B9AB" modified="2013-12-11" version="1">MDAPSTRALISSIIQQLASFTTGETTDFSNLPPKAQQLLVTLHCLLPTTLLPALDLLDRELVIRVSDTTVPEPQRAYYVRSITPVTSTGKFSAQPIRYEVRLRPWNCTCASFTFAAYKDLGKDEPLELEQTEEAEEPEEPEETEEQEETEETEDTEDIEEIEDTEGTEKTIWGGITQDRNPPVCKHLLACVLGEYCFRDRVIEETVGQMAMAEMTFQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KXT9</accession>
    <name>U4KXT9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935304">
        <property type="protein sequence ID" value="CCX06666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KXT9"/>
    <dbReference type="OMA" id="ICHICRE"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX06666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="240" mass="27257" checksum="0FFF666BC36939EE" modified="2013-12-11" version="1">MVRVGSSSRNSSESPSQQELERIYNIRRQLDDNISHAFDDFHAHSKICHICREPIRRYQAHEDLCDVGIILTQHISTLLYKKAEHCPDGKFSVTYPAGYHAVDQVVRMIAHYHHGEYDLNIMDIRRFPIGPVVDSDHNKGSEYDADRERRQLQRERRSGASLDPSPRSSMRSDNSRSPRSSHSPRSSGGDWGNPHTSFMDLPTGQTQAGASPVSSNASVDSRRSVHFKPTVHVREFSNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>U4KY79</accession>
    <name>U4KY79_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935323">
        <property type="protein sequence ID" value="CCX06926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KY79"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="164" mass="18574" checksum="7D7CBF4FC3A033EC" modified="2013-12-11" version="1">MALAYRSVNNPWRKTSLHYKFFCLLWFMVIDFGTRDEDRAAIKTECLLDCPRRHIGLFIMQAVNLSWNPAYTKEVLATKKLERVLPSKATSFDMSSFVYEIFAPGSRSILLTLLDLSEPLLPVQLSAAKLPTLPGLATPIMRRLTGEQWQALLDILQGRSTVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYQ2</accession>
    <name>U4KYQ2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935350">
        <property type="protein sequence ID" value="CCX07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYQ2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="26" mass="2932" checksum="9E8BF23049BDB6D4" modified="2013-12-11" version="1">MSTALLLVHHSRWLGGIPKLPFCLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYU7</accession>
    <name>U4KYU7_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PCON_03791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 100304</strain>
            <tissue evidence="3">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935218">
        <property type="protein sequence ID" value="CCX04809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYU7"/>
    <dbReference type="STRING" id="1076935.U4KYU7"/>
    <dbReference type="eggNOG" id="ENOG502RZ2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFFVAPK"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF42">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCX04809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46148" checksum="7E55366CF82D38D7" modified="2013-12-11" version="1">MPERRTISVLVVGSGLAGLTAAHLLHNDKRQRYDVTIFEQGPVPSLSSASLSTPSGPIDIPMRSFTASYYPHLSRVLQYLHLPVRPEPFLFSFPSYSHPSRLASLPPRPSHRSWPQHIRLLAALAFAYAYFIFTCFFLPPSDSEDFGQWMKRVRLPGWFVGEYILPLMAAVATCDHAELLAFPAKDVVGYKRVTNGEPHVVVADGVGALQRQLLEGGKAGAVKIELNRRVHRIQGAVQGPKVVTYLEDGAEVTGVYDKVVLAVTPDVVGGIYAPLKEKMSRIPTKKVEVVAIREEGREGEIILRSKGGETEARHCARGLVTVTGPLTAIGDGKSGASTPSEPSSGASSGASTPSQEESKVIRRSVFTRVLRSVESRQVVKSLEKSNGDDGVFVVGGWCWDGMVLLEGCVRSAEGVARKLGVEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4KYX7</accession>
    <name>U4KYX7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Protein kinase gsk3 acc. no. Q10452</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PCON_06795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 100304</strain>
            <tissue evidence="10">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF935341">
        <property type="protein sequence ID" value="CCX07206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KYX7"/>
    <dbReference type="STRING" id="1076935.U4KYX7"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCX07206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="395" mass="45205" checksum="1314609774689720" modified="2013-12-11" version="1">MSQSRPAQFSGLRMGEVIREKVQDGMTGETREITYTQCKIVGNGSFGVVFQTKLSPSNEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEFVPETVYRASRFFHKMKTTMPSLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPASGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTPKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFSKVFRKATPDAIDLISKLLEYTPTQRLSAIDALTHPFFDELRDPNTKLPDSRGLNNNGPRDLPELFNFTRHELSIQPSLNKKLVPEHARAALLAKGLDIDNFTPMTKDEMMAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4KZF6</accession>
    <name>U4KZF6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_06672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4KZF6"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX07085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="284" mass="32520" checksum="B0BFB2AB7F3B6098" modified="2013-12-11" version="1">MATATHPTPLEKQTIVVRCEPWSDNRIIRYGLLTNNIIRYEIVNFGSLFRHILKAISIILKSNCDEPEPEELPRTANFTFKDLQEWNQAFNTEQYPLDDLLSEYGGTGLKHMIQIPYLMISDYSSHYYKKLPETRCEEFQRLIEDSDATLSDCFKNDGSYSYSYAAEDEAVIDGLRPALYLKYKEMSDMFDLKLNRKSNTGDQPDDLEDSISDTFAWEALFKFTVGHLKALEPILNRCKAKKAAREQKAAKPPASDDEALSQQAELRGGCNDDERTGEESKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Y2</accession>
    <name>U4L0Y2_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_08063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935416">
        <property type="protein sequence ID" value="CCX08470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Y2"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="25" mass="2776" checksum="9BB1FE19289E6089" modified="2013-12-11" version="1">MEAPMLQWVGYPALSSARVRIPEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4L0Z1</accession>
    <name>U4L0Z1_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PCON_07512</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 100304</strain>
            <tissue evidence="18">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935382">
        <property type="protein sequence ID" value="CCX07923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L0Z1"/>
    <dbReference type="STRING" id="1076935.U4L0Z1"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCX07923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17869" checksum="764FE584472A8509" modified="2013-12-11" version="1">MSLCVNRLQEERKQWRKDHPFGFYAKPAKAPQGGLDLMKWSCGIPGKEKTQWEGGLFKLEMTFPEEYPTKPPKCKFVPPLFHPNVYPSGTVCLSILNEDEAWKPAITIKQILIGIQDLLDDPNPDSPAQAEAYGLFKKDRAAYDRKIKLIVRENPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1M8</accession>
    <name>U4L1M8_PYROM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_09030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935465">
        <property type="protein sequence ID" value="CCX09437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1M8"/>
    <dbReference type="OrthoDB" id="5474973at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX09437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="375" mass="40034" checksum="03956C5370FD0974" modified="2013-12-11" version="1" fragment="single">MAALSKLAEDEHDVVLVDSLEHEPSPILRALKALSTTFSYIDISTPSNTSSNPPVSQAPRRRPVKFEIGPPSSSSSDTSSSPEHSAPLLTMQQHGRSSDEGTGSSPSSPSINADAPTASPPSPKVRWSFEENTPRLVEDLSPIERSILFAQKTGYLSSSPKTSPEPLVGPLPIPEVGQVGNKQSSTAPAKQFPPSLSSIQRASTNSSTNAESDQPSPTRPPLKRQPPHTPRLANLRSISNPLSAIPTVTTMAPPLNEYEVKAYKISAQAGTNSPPVPITVKVKINPPLYDSWSIDLGMQFPKIQAGKSYFRFGFDPVESVRAYIEVSADHSGCSCGRARLSELAEKRKASQTQENRKPAPTPAPTPAQAPTPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4L1T8</accession>
    <name>U4L1T8_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PCON_09628</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 100304</strain>
            <tissue evidence="16">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DMA1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="HF935502">
        <property type="protein sequence ID" value="CCX10035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L1T8"/>
    <dbReference type="STRING" id="1076935.U4L1T8"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LRTHHTH"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000426">
        <property type="entry name" value="DMA1p Ubiquitin-protein ligase (E3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCX10035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="600" mass="63484" checksum="D90E042A1B1E6AE9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2F3</accession>
    <name>U4L2F3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935545">
        <property type="protein sequence ID" value="CCX10486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2F3"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX10486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="68" mass="7329" checksum="CE9A4BE5FAAFF7AF" modified="2013-12-11" version="1">MPRGITISSCSTSSKFPNHAISRMDTTSRLHGPIRPQTSSNNHTTSTGSPPRRSNSKTCKSPISTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>U4L2Z7</accession>
    <name>U4L2Z7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935202">
        <property type="protein sequence ID" value="CCX04410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L2Z7"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="292" mass="34303" checksum="5C020757D97F2089" modified="2013-12-11" version="1">MEKKYRAEQAQKEKERVEREKRELDKRVMEEKQKLEQEAERRRVISEKRKQTLEEQAKGTEKRDGKASQLCGAAQRELDRKTRNEKNQELKVKLSGTAPGASVGQEKESLEQEERGEKVKRAWEHEKELVQHGSEQRVKETDERLKQVEERRKAQVKNEAEAAKRREQYNARIKREEEGTQEQSQEREKREREEDERERQKAEAEQKEKQKAEDEKKREGQEKTGILPALEHIFISKGRSTNCKSSVNPMAKDPDGTTSHWTTSSRTSTTASPRDMSTWTTYSLYGTSRLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>U4L388</accession>
    <name>U4L388_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_06365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935312">
        <property type="protein sequence ID" value="CCX06778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L388"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX06778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="72" mass="7840" checksum="B8C385EB3802ACCC" modified="2013-12-11" version="1">MFFFSFGVKTTHQSQPWFCFSLPAQPPPSSLPYRNGLPLSYIGSPAWVKPSSIPGTRKGLLATTQINVSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3C7</accession>
    <name>U4L3C7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Methyltransferase-like protein 4 acc. no. Q3U034</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_02735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935208">
        <property type="protein sequence ID" value="CCX04555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3C7"/>
    <dbReference type="STRING" id="1076935.U4L3C7"/>
    <dbReference type="eggNOG" id="KOG2356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX04555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="384" mass="42373" checksum="80EDF2D86808C954" modified="2013-12-11" version="1">MSLFNTSHCTVLDIPTTHSTPPGLRLRSSPAPIIPYKPTLQPTSDIAAHTRLLPRLLTALSSLPTDAPFHTPRLPPPNPEDELNFTDPNLLLCTTEPDLEDLEDPFDPQPCPETVDDLSDLLIAGILTNASEEWKTMTITHPTPSRPFHIPPRSSFQLGRITPASFAPLGKGTVDFLLLDPPWPSASAQRKRKRGTSGTAAAGGYRTENRFEIWELLEGLPVGEVLAKDGVVAVWITNAGRVRKGVEGLWKKWGLEERAEWCWVKITTSGEAVVSLEAEGKRGYEVLLMGARKGEASLAAPLARLLENKVVVGVPEVHSRKPCLRKIVEKEMPGHKGVEVFARCLTEGWTSFGDEVVRFNWEGWWGDEVECGEDDEVDKDKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>U4L3Q4</accession>
    <name>U4L3Q4_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_10969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935612">
        <property type="protein sequence ID" value="CCX11375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L3Q4"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="399" mass="43185" checksum="B8DF1E98967CEF99" modified="2013-12-11" version="1">MAEPPSERTKVHTQNKTGGEEHPSEDNSAALLAPVVKNSVSQSGIAVDISAQPKPQAEKSVSGESDKKSPQDTITEISAQENLVPRLDSGDLESKAPGGKGPENIGPAKKDQAKKDQAKKDQAKKDQAKKGLENANGNNNIQEQRSGWHLKITNSDVAGAKSVDAFDIVLVQVCKEECWDWLVDLFETVTDGPVMAGYTKTEAAASPDLKLPSRQKQTNATSKQTPTAGTTYEARILQFQLQSKSNLNFDDLATNLRIQLSNERKNAGDETKPIIFVGGKSTVASKIMHGLFNPEDSTHMSRSLSKSLGIDGATAAVIFMNRDPPKSTEDSTASENNNGIGSSENLNHDIELNQSTQFETGAGTHTSFDLPDIKVLYDVIFFTLQEWWEGAQFCEPTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>U4L4P6</accession>
    <name>U4L4P6_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_04494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935229">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
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            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
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            <begin position="259"/>
            <end position="276"/>
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        <location>
            <begin position="315"/>
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    </feature>
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            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
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            <end position="446"/>
        </location>
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            <end position="506"/>
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            <end position="530"/>
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            <end position="556"/>
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    </feature>
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        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX05005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="653" mass="71138" checksum="0E5D442F6339D6E1" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5T9</accession>
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        <submittedName>
            <fullName evidence="5">Similar to Ribosome-interacting GTPase 2 acc. no. P53295</fullName>
        </submittedName>
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        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
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                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
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            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 100304</strain>
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        </source>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
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    </dbReference>
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        <property type="entry name" value="Putative GTP-binding protein 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="367"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCX12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="368" mass="40525" checksum="A49BEFC8D86CF06D" modified="2013-12-11" version="1">MGVAEKIKEIEDEMKRTQKNKATEYHLGLLKGKLARLRAQLLEPGPGEKSGGAGSGFDVSKSGDARIALVGFPSVGKSTLLSKITKTKAAVAAYAFTTLTAIPGVMEYGGAEIQILDLPGIIEGAAEGKGRGRQVISAAKTSDLIMMVLDATKKAEQRALLEKELEAVGIRLNKSPPNIYLKVKKTGGMKITFMSPPKNLDEKMIYNILRDYKILNCEVLVRDENCTVDDFIDVIMAAHRKYIRCLYVYNKIDCVSLSFLDQLAKEPHTAVMSCELDLGVTDVVDRAWEELNLLRIYTKRKGIAPDFSEALIVRQNSTIEDVCDAIHRSLKDKFKYALVWGASARHIPQRVGLSHLVADEDVVSIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5X7</accession>
    <name>U4L5X7_PYROM</name>
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        <submittedName>
            <fullName evidence="4">Similar to Protein AIR2 acc. no. Q12476</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PCON_05002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
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                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935253">
        <property type="protein sequence ID" value="CCX05415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
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    </feature>
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        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX05415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="371" mass="40074" checksum="B01FC5036A67D4FF" modified="2013-12-11" version="1">MVRKRQRNDFDSPPHSSDEEGEITSRAELAGSCSTKKRNRGFQDLTSDTSRPPSVGNSSPKKEEGEVSDSDDDSDANYEPTYNPPEEAEANDAKAPEIPEDDDELQRKYFQPYQFPSNPREEARAMFDNNEPPLRLEPQARKLAPITDRKCTICNSSSHNSAGCPELTCTNCGAYNKHFTRSCPVVDLRGSTSPPPSSSNTYDWRSETPRRTTPFHRNTLKACCYNCAGIGHYGYDCPDLRFSTHKGEPGSFSGLHAMSYVAASDNQSLAGYDRESKTLIVANRTANWGRAQRESEMAEAFDPFKAFKKTSGGGGGNRSYGGYNGGYGGGGGGGGYRGGHGGGGRGGGEGIIDPCRAQQVGIGDNSSGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>U4L5Y3</accession>
    <name>U4L5Y3_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to phospholipase A2 group XIII [Tuber borchii] acc. no. AAF80454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_11311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935638">
        <property type="protein sequence ID" value="CCX11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L5Y3"/>
    <dbReference type="eggNOG" id="ENOG502S8PP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKGFANT"/>
    <dbReference type="OrthoDB" id="5120271at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651939" evidence="1">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="202" mass="22228" checksum="0C1D06C58F70E166" modified="2013-12-11" version="1">MKFTTILVVSLTTLASALPVADIAIPRGNVPDTVELGVDEFNNWGIDHRGKVPDVTNLATDIVPESAVAKDNIIARGIAWLTKRETDPEATDRLLFSTSISNFLYAKSIKNPGSLDWTDDGCSNSPDAPAGYNFLPSCQRHDFGYRNYKKQGRFTDANRLRIDNNFKSDLYNQCATYNAASEVACKGFANTYYEAVRAFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>U4L643</accession>
    <name>U4L643_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935255">
        <property type="protein sequence ID" value="CCX05490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX05490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="9" mass="1008" checksum="00E8B1ADD047673B" modified="2013-12-11" version="1">MYLPIATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>U4L663</accession>
    <name>U4L663_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935725">
        <property type="protein sequence ID" value="CCX12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L663"/>
    <dbReference type="OrthoDB" id="5304262at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="321" mass="34998" checksum="1364D8C35290E708" modified="2013-12-11" version="1">MRSRTSSRPTPIETATSPTTKKESHPPIVPPLTPTTERELRKSCSLLMMNPAPKTRERSATQPATRPMTSGSGAGGISITRAEFEPTLPDMPRSPLPPRTMTESPIPHKPFATESVSSRSHTPPPRSFTNESFTRSHTPPPSAFAFAHTATARKLSASTESGVPMSGVRASQIEIRRVVKDFEPTLPTTIDRNSTFLIAKPTIVEVGGARPRTAGTNSSRSWGELKAGSERSGSIDEEDINKRMSLFPRPRTAHGGESPEDHQQYPMPPLPGSVVRTGSGLKTEIVAEVLPMEKKSKKAGFVQFSAFFKATFRFGKRVRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4L6I7</accession>
    <name>U4L6I7_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized N-acetyltransferase MJ1207 acc. no. Q58604</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_12144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935720">
        <property type="protein sequence ID" value="CCX12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4L6I7"/>
    <dbReference type="STRING" id="1076935.U4L6I7"/>
    <dbReference type="eggNOG" id="ENOG502SAUS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617:SF20">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE RIMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="211" mass="23394" checksum="ABFB4CEF04BC795E" modified="2013-12-11" version="1">MHIRPYSPPDYDSCEATSHPALTSAIPLVPYVYAIPYLFYSPDYCFVLVTDDSDIPKPNQISIQPTSKERTGNVVGFILGTPSTIDFVSEYASNYNPELPELELSTAVDILTRDALRPQRMLVGLESKWPAHLHINILPGWQGGGWGAKLINTLLEKLKGEGVRGVHLGMAEDNDGAGRFYKRCGFQLASEIPEVPQEGMKGAKWFVKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>U4L839</accession>
    <name>U4L839_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Exocyst complex component 1 acc. no. Q9NV70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PCON_13899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 100304</strain>
            <tissue evidence="8">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF935952">
        <property type="protein sequence ID" value="CCX14306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1076935.U4L839"/>
    <dbReference type="eggNOG" id="KOG2148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFMRVFP"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCX14306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="1396" mass="154685" checksum="DB06DDFFD257547C" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA17</accession>
    <name>U4LA17_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to WSC domain-containing protein 2 acc. no. A2BGL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PCON_13972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 100304</strain>
            <tissue evidence="4">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935967">
        <property type="protein sequence ID" value="CCX14379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA17"/>
    <dbReference type="STRING" id="1076935.U4LA17"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VNGWDVP"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004651804" evidence="2">
        <location>
            <begin position="20"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="351"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCX14379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="480" mass="51750" checksum="5E1577A15E679970" modified="2013-12-11" version="1">MKTSAVIFAAAALLNGADAFFRMPCAGPLILERSDPIVNAGAVSAHLHNVVGANAFNFTMTYKDAITATCSTCKAKADKSNYWIPDLFVKAKNGSFHNVNNGGATIYYLQRRDNPNEELIPFPEGFRMVAGNPMIRSLATGAQKNGASFACLGANKPETPMIPNYKCPSGLRAQMVMPSCWDGVNLDSPDHKSHVAYPSLIDNGKCPPTHPKRFITLFYEFLYDIASWDSEWNGDQHPFVLANGDPTGYSFHADFINGWDTPTLKRAINECNAESGVIEECKVLDLFSDKEINDCIVPPSVKEQTTGWLDRLPGCNAIQPGPGNAVQGVNCGATTIIGPKTTYSTDVSAKGWKYVGCASDDLGARTLPVRYAKKDMTVPMCIDYCVSQGYTYAGLEYTEECYCGNSIDQSRLGAQKCTMPCGGDSSQYCGGSQKLSIYQKNGAAAIKPNVPATKPSAKGPGATAAPASGRPSSRRMRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4LA72</accession>
    <name>U4LA72_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PCON_06646</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 100304</strain>
            <tissue evidence="23">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="HF935332">
        <property type="protein sequence ID" value="CCX07059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LA72"/>
    <dbReference type="STRING" id="1076935.U4LA72"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
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        </source>
    </evidence>
    <sequence length="1044" mass="117606" checksum="AFFC23BDDBC9A402" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAT0</accession>
    <name>U4LAT0_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein YJR056C acc. no. P47115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PCON_01729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 100304</strain>
            <tissue evidence="2">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF936168">
        <property type="protein sequence ID" value="CCX15454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAT0"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCX15454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="293" mass="33348" checksum="A95D343579E92C61" modified="2013-12-11" version="1">MDMQSLSTNLPKQNRPDPELAQAFRTAAHSITLLYTKAGENAGKARQDGLKEGYARCLDDVLSLINTLEERKTPQTSRNETIRQWTLFKKRKLAAEPNLDKDLDDILNSGQREREMSTMEEDQSTPAPTTEHGPFQSESTPTQNTFPAQSIPQPPLHNIFQPEIIQQTSLYNPFQTESTSEIFLPPTPTSNAFTQRHSTPELGSEADQNFSRSSTPSETIDSRNFNEGNMDARIFHDGIMQQSIPPAFRNYVPQVKMLDSTKSGNNMKPSRNRRKKRRAEEDDCIDKKKSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>U4LAW6</accession>
    <name>U4LAW6_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PCON_03322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 100304</strain>
            <tissue evidence="11">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF936491">
        <property type="protein sequence ID" value="CCX16623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LAW6"/>
    <dbReference type="STRING" id="1076935.U4LAW6"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NYDLISW"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCX16623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="582" mass="64995" checksum="C272FFED50054BFD" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4LBE9</accession>
    <name>U4LBE9_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Glutaredoxin acc. no. P55143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PCON_04398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 100304</strain>
            <tissue evidence="6">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="HF936646">
        <property type="protein sequence ID" value="CCX17394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LBE9"/>
    <dbReference type="STRING" id="1076935.U4LBE9"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYTSPLC"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCX17394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="104" mass="11289" checksum="FFE750473184B3E9" modified="2013-12-11" version="1">MVSQAAKTKVQKIIDENPVAVFSKSYCPYCTASKKTLTEMGAKFFLIELDQEKDGSELQEALQEISGQRTVPNIYIAQQHIGGNSDLQAKKSELPALLKSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCL8</accession>
    <name>U4LCL8_PYROM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PCON_05689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 100304</strain>
            <tissue evidence="1">Vegetative mycelium</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF935279">
        <property type="protein sequence ID" value="CCX29618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4LCL8"/>
    <dbReference type="Proteomes" id="UP000018144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCX29618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018144"/>
        </source>
    </evidence>
    <sequence length="40" mass="5014" checksum="AE266F229AF4ADE6" modified="2013-12-11" version="1">MAATFRHFFGSSALWRMYWDPVASEWGFRSFRWRWDILIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4LCV5</accession>
    <name>U4LCV5_PYROM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PCON_07726</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pyronema omphalodes (strain CBS 100304)</name>
        <name type="synonym">Pyronema confluens</name>
        <dbReference type="NCBI Taxonomy" id="1076935"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Pyronemataceae</taxon>
            <taxon>Pyronema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003820" last="E1003820">
            <title>The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.</title>
            <authorList>
                <person name="Traeger S."/>
                <person name="Altegoer F."/>
                <person name="Freitag M."/>
                <person name="Gabaldon T."/>
                <person name="Kempken F."/>
                <person name="Kumar A."/>
                <person name="Marcet-Houben M."/>
                <person name="Poggeler S."/>
                <person name="Stajich J.E."/>
                <person name="Nowrousian M."/>
            </authorList>
            <dbReference type="PubMed" id="24068976"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003820"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 100304</strain>
            <tissue evidence="14">Vegetative mycelium</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
